Digital Commons Network^™

Delivery Of Bikdd Proapoptotic Gene In Peptide-18 Targeted Poly(2-Oxazoline)-Dope Nanoliposomes For Breast Cancer Models, Zeynep Büşra Bolat, Ayça Ece Nezi̇r, Ongun Mehmet Saka, Itir Ebru Zemheri̇, Sevgi̇ Gülyüz, Umut Uğur Özköse, Özgür Yilmaz, Asuman Bozkir, Di̇lek Telci̇, Fi̇kretti̇n Şahi̇n

Turkish Journal of Biology

Breast cancer is the most common cancer type and the major cause of death in females worldwide. For effective breast cancer treatment, systems with promising delivery of anticancer agents is an important strategy. Peptide 18 (P18), a tumor homing peptide, shows high binding affinity towards breast cancer cells. Nanoliposomes are known to have enhanced accumulation ability in tumors with longer systemic circulation. Poly (2-ethyl-2-oxazoline) (PEtOx) polymers conjugated with DOPE were used to prepare PEtOx-DOPE nanoliposomes. BikDD is a mutant form of Bik gene, a member of the BH3-only proapoptotic genes, mimics the constitutively phosphorylated form of the gene. To the …

Pterostilbene Suppresses Head And Neck Cancer Cell Proliferation Via Induction Of Apoptosis, Tali̇h Özdaş, Si̇bel Özdaş, İpek Canatar, Erdem Kaypak

Turkish Journal of Biology

Background/aim: Head and neck cancer (HNC) is one of the most prevalent causes of death worldwide, and the discovery of anticancer agents for its prevention is very important. Pterostilbene (PS) is a trans-stilbene reported to be beneficial in managing various cancers. The objective of the study was to evaluate the cytotoxic, anti-proliferative, pro-apoptotic and anti-migrative effect of PS on HEp-2, SCC-90, SCC-9, FaDu and Detroit-551 cell lines. Materials and Methods: MTT and live/dead assays were employed to assess cell-viability, while cell migration test was performed to evaluate wound healing capacity. The mRNA, protein and intracellular expression level of CASP-3, BAX …

Optical Imaging And Gene Transfection Potential Of Linear Polyethylenimine Coated Ag2s Near-Infrared Quantum Dots, Altay Savalan

Turkish Journal of Biology

Background/aimApplication of biocompatible heavy metal free and cationic Ag2S NIR QDs, which are highly luminesce in the medical range (700-900 nm), as a non-viral gene delivery system paves the way to overcome the auto-fluorescence and easily track the delivery of the genes in real time as it happens.Materials and methodsHere, the newly developed small and colloidally stable 2-mercaptopropionic acid (MPA)-capped Ag2S aqueous quantum dots electrostatically complexed with linear polyethyleneimine (LPEI) (Ag2S@2MPA/LPEI) was investigated for the first time both as a strong fluorescent probe and as a non-viral gene delivery vector for the highest tracking of the system and delivery of …

Overlooked Ionic Contribution Of A Chiral Dopant In Cholesteric Liquid Crystals, Hassanein Shaban, Po-Chang Wu, Yi-Fei Jia, Wei Lee

Basic Science Engineering

This study focuses on the ionic contribution by a chiral dopant added into a nematic host for preparing cholesteric liquid crystals (CLCs). Chiral structures were designated by individually incorporating two enantiomers, R5011 and S5011, into the nematic E44 to construct right- and left-handed CLCs, respectively. Characterized by the space-charge polarization, the dielectric spectra of the CLCs were investigated in the low-frequency regime, where f ≤ 1 kHz. The role of the individual chiral dopant, R5011 or S5011, at concentrations of 0–4.0 wt.% in altering the ionic properties of the CLC material was analyzed by deducing the electrical conductivity, ion density, …

Unh Names Aaron Howell Executive Vice President For Finance And Administration, Tania Deluzuriaga

UNH Today Archive

No abstract provided.

Catching Up With 2024 New Hampshire Teacher Of The Year Elizabeth Duclos ’06 ’07g, Michelle Morrissey

UNH Today Archive

No abstract provided.

Determining The Prognostic Value Of Complete Blood Count Subgroup Parameters In Staphylococcus Aureus Bacteremia, Emily L. Matthews, Thomas J. Dilworth

Journal of Patient-Centered Research and Reviews

Purpose: Serum cytokine alterations are associated with increased Staphylococcus aureus bacteremia (SAB) mortality. Unfortunately, clinical use of these cytokines is uncommon due to limited availability and high cost. Complete blood count (CBC) with differential reflects the host immune response, and CBC subgroup parameters may have prognostic value in SAB. We sought to determine the association between CBC subgroup parameters on the day of index blood culture and 30-day all-cause mortality in SAB patients.

Methods: We conducted a retrospective study of adult SAB patients with infectious diseases consultation to evaluate the discriminatory capacity of CBC subgroup parameters in predicting SAB mortality. …

Factors Influencing Self-Wound Care Adoption In Singaporean Communities: A Cross-Sectional Survey, Ling Jia Goh, Xiaoli Zhu

Journal of Patient-Centered Research and Reviews

Purpose: Managing wounds often requires frequent clinic visits, posing a burden on both patients and the healthcare system. Shared wound care, which encourages patients to manage dressings at home, has emerged as a potential solution. This study investigates factors influencing self-wound care adoption in Singapore.

Methods: A cross-sectional survey involving 328 participants from six primary healthcare centers was conducted. The survey examined demographics, wound characteristics, and perceptions towards shared wound care using a locally validated questionnaire. Parametric tests and logistic regression were used to analyze the data.

Results: Unlike older participants, younger adults valued time saved through self-care and found …

“It Is What It Is” – The Lived Experience Of Women With Breast Cancer Undergoing Axillary Lymph Node Dissection, Eva Vikhe Patil, Anna Forsberg, Carina Wennerholm, Jenny Drott

Journal of Patient-Centered Research and Reviews

Purpose: The lived experience of women undergoing axillary procedures as part of their breast cancer (BC) treatment remains unexplored. This lack of in-depth understanding could hamper implementation of person-centred care, which is concerning because BC is the most common form of cancer in women. The aim of this study was therefore to explore the lived experiences of women undergoing axillary lymph node dissection (ALND) due to BC.

Methods: Twelve women with a mean age of 59 years were interviewed about their lived experiences of axillary procedures as part of their BC treatment. The interviews were recorded, transcribed verbatim, and analysed …

Assessing The Climate Readiness Of Physician Education Leaders In Graduate Medical Education, Deborah Simpson, Anne Getzin, Aaron A. Levy, Victoria Gillet

Journal of Patient-Centered Research and Reviews

Climate change affects patient health through an array of exposures, including increasing heatwaves, extreme weather events, poor air quality, and expanding vector-borne illnesses. Physicians are at the forefront of addressing the health consequences of these exposures with patients, and environmental sustainability has become a priority for health care organizations. Accordingly, climate change and health is becoming a critical area for graduate medical education (GME). As GME leaders design and drive education in residency and fellowship programs, understanding those leaders’ baseline knowledge on this topic and its alignment with their organizations’ priorities is an essential step in the development of climate …

Topography Of The 410 And 660 Km Discontinuities Beneath The Tibetan Plateau And Adjacent Areas, Zexin Miao, Stephen S. Gao, Muchen Sun, Kelly H. Liu

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

To investigate the three-dimensional spatial distribution of subducted oceanic slab segments and their consequential effect on the thermal and hydrous composition of the mantle transition zone (MTZ) beneath the entire Tibetan Plateau, we conducted a comprehensive analysis of approximately 655,000 P-to-s receiver functions (RFs), obtained from 735 broadband seismic stations. These RFs were utilized to delineate the 410 km (d410) and 660 km (d660) seismic discontinuities, which represent the upper and lower boundaries of the MTZ, respectively. The RFs were grouped within circular bins with a radius of 1 degree and stacked to image the discontinuities. The mean apparent depths …

United States Centers For Disease Control And Prevention Scientific Integrity Policy

Copyright, Fair Use, Scholarly Communication, etc.

US CDC SIP

Adipocyte Lipin 1 Expression Associates With Human Metabolic Health And Regulates Systemic Metabolism In Mice, Andrew Lapoint, Jason M. Singer, Daniel Ferguson, Trevor M. Shew, M. Katie Renkemeyer, Hector H. Palacios, Rachael L. Field, Gordon I. Smith, Mai He, Gary J Patti, Samuel Klein, Jonathan R. Brestoff, Brian N. Finck, Et Al.

2020-Current year OA Pubs

Dysfunctional adipose tissue is believed to promote the development of hepatic steatosis and systemic insulin resistance, but many of the mechanisms involved are still unclear. Lipin 1 catalyzes the conversion of phosphatidic acid to diacylglycerol, the penultimate step of triglyceride synthesis, which is essential for lipid storage. Herein we found that adipose tissue LPIN1 expression is decreased in people with obesity compared with lean subjects, and low LPIN1 expression correlated with multi-tissue insulin resistance and increased rates of hepatic de novo lipogenesis. Comprehensive metabolic and multiomic phenotyping demonstrated that adipocyte-specific Lpin1-/- mice had a metabolically unhealthy phenotype, including liver and …

Ethical Leadership Case Collection: The Offer: Bribery Over Recruitment, May Phuu Thwel, Natalie Castelan Marquez, Zena Musleh

GHEA21 Open Educational Resources

The Ethical Leadership Case Collection is the product of the Network Collaborative Course entitled Ethical Leadership. The course explores approaches to ethical leadership not just in the abstract, but as a discipline that is focused on action. The course is grounded in students’ perspectives on the ethical and leadership challenges they face in their own lives and communities. As an approach to thinking through ethical leadership, the course is structured around the concerns explored in Dr. Mary Gentile's Giving Voice to Values framework. Students developed case studies of their own.

Ethical Leadership Case Collection: Nepotism In The Admissions Office, Sydney Williams, Benjamin Akakpo, Fahim Islam Farhan

GHEA21 Open Educational Resources

The Ethical Leadership Case Collection is the product of the Network Collaborative Course entitled Ethical Leadership. The course explores approaches to ethical leadership not just in the abstract, but as a discipline that is focused on action. The course is grounded in students’ perspectives on the ethical and leadership challenges they face in their own lives and communities. As an approach to thinking through ethical leadership, the course is structured around the concerns explored in Dr. Mary Gentile's Giving Voice to Values framework. Students developed case studies of their own.

Ethical Leadership Case Collection: Fast Fashion Shopping, Hristian Dsouza Michaeli, Ming Thet Paing, San San Maw

GHEA21 Open Educational Resources

The Ethical Leadership Case Collection is the product of the Network Collaborative Course entitled Ethical Leadership. The course explores approaches to ethical leadership not just in the abstract, but as a discipline that is focused on action. The course is grounded in students’ perspectives on the ethical and leadership challenges they face in their own lives and communities. As an approach to thinking through ethical leadership, the course is structured around the concerns explored in Dr. Mary Gentile's Giving Voice to Values framework. Students created developed case studies of their own.

Path Following Control And Simulation Analysis Of Multi-Articulated Vehicles, Yu Zhao, Caijin Yang, Tanming Wang, Jing Xu, Shuai Zhou

Journal of System Simulation

Abstract: The structure of multi-articulated vehicle body limits the flexibility of the vehicle and causes the deviation of the rear vehicle. Taking the ideal articulation angle as the control target, a feedforward plus feedback path following control method is proposed, which realizes the precise path following of rear vehicle bodies by minimizing the deviation between the ideal articulation angle and the actual articulation angle. According to the geometric position relationship between the vehicle and the desired path, the traditional calculation method of the ideal articulation angle is improved from two perspectives of application range and error accumulation. Based on the …

Improved Foggy Pedestrian And Vehicle Detection Algorithm Based On Yolov5, Tong Su, Ying Wang, Qiyang Deng, Zhaobin Li

Journal of System Simulation

Abstract: Due to the poor environment perception of car in bad weather, the detection ability on dynamic targets is significantly reduced, and thus the problems such as low accuracy and poor robustness of the deep learning-based target detection network will occur when detecting pedestrians and vehicles in foggy days. A YOLOv5-SGE foggy detection network is proposed on the basis of the combination of image dehazing DehazeNet and the improved YOLOv5. The adaptive calculation of anchor frame is realized by canceling the initial anchor frame of YOLOv5, and the anchor frame suitable for the current dataset is generated. A three-dimensional weighted …

Peer-To-Peer Energy-Carbon Management Method Of Multiple Integrated Energy Systems Considering Multi-Agent Interaction Strategy, Yudong Wang, Junjie Hu

Journal of System Simulation

Abstract: To explore a new energy management model of P2P transaction of electricity, heat and carbon among IES with the participation of ESP, a P2P energy-carbon management method of IES considering multi-agent interaction strategy is proposed. A two-layer energy management framework with the multiagent participation of involving ESP and IES is established. A two-layer electricity-heat-carbon energy management model is constructed in which the upper model is constructed based on reinforcement learning framework to optimize the energy management strategy between ESP and IES cooperative alliance and the lower model is based on Nash negotiation game theory to optimize the cooperative operation …

Addiction, Spiritualité Et Religion, Bechir Aouad, Père Edgard El Haiby

Horizons et Conjonctures

L’étude examine comment le vide spirituel mène aux addictions aux substances et aux comportements compulsifs comme substitut à la transcendance authentique. Elle analyse les dépendances comportementales telles que le jeu ou la sexualité compulsive et met en évidence l’influence de la dimension religieuse. Elle conclut sur l’importance d’intégrer la spiritualité dans le traitement pour offrir la force et la résilience nécessaires au rétablissement durable.

Mots-clés

Dépendance, Spiritualité, Religion, Addiction, Substance, Santé mentale, Réhabilitation, Toxicodépendance, Prévention, Support psychosocial, Substance psychoactive

كلمة التحرير, لينا إسكندر حّّواط

Horizons et Conjonctures

تطلق كلية العلوم الدينية في جامعة القديس يوسف في بيروت مجلتها العلمية المحكمة «آفاق وسياقات»، التي تمثل انطلاقةً منهجيةً واضحة في دراسة الظاهرة الدينية ضمن أبعادها التاريخية والاجتماعية والوجودية. يهدف هذا الإصدار الأول إلى ترسيخ نهج بحثي نقدي يربط الفكر الديني بسياقاته الواقعية، في محاولة لتجديد المقاربة الأكاديمية للدين في مجتمعاتنا
[...]

الاعتقاد ضمن السياق المؤسّسي: النهج الفلسفي في مؤسّسات الإيمان, مرغريت الأسمر بو عون

Horizons et Conjonctures

خلاصة

يستكشف هذا المقال مفهوم الاعتقاد في الإطار المؤسّسي، مع التركيز على الجوانب الفلسفيّة للمؤسّسات العقائديّة أو الإيمانيّة. يتناول الجزء الأوّل فهم جوهر مؤسّسات الاعتقاد، ودراسة كيفيّة تشكّل هذه الهياكل المنظّمة وتوجيهها للمعتقدات الفرديّة داخل المجتمع. أمّا الجزء الثاني، فيتناول كيفيّة التلاعب بالمعتقدات داخل هذه المؤسّسات، مع تسليط الضوء على الآليّات والقضايا المرتبطة بإدارة المعتقدات الجماعيّة من خلال أمثلة واقعيّة.‏

كلمات مفتاحيّة

الاعتقاد، مؤسّسة الإيمان، الخطاب الديني والسياسي، الدين، فلسفة الدين‏

Résumé

Cet essai philosophique explore le concept de croyance dans un contexte institutionnel, en se concentrant sur les aspects philosophiques des institutions de croyance ou de foi. La première …

الدولة والسلطة – مصادر المجتمع المدني الإسلامي وفقًا لمحمد مهدي شمس الدين, أحمد علي محسن, رولا تلحوق

Horizons et Conjonctures

خلاصة

لا تجادل هذه الورقة في أحقّية الحكم أو في طبيعة الدولة بحدّ ذاتها، ولا في المؤسّسات التاريخيّة مثل الخلافة، بل هي بمثابة بحث عن الأصول التاريخيّة التي تولّد السلطة في الإسلام. ترتكز الدراسة على أعمال الشيخ محمد مهدي شمس الدين حول المجتمع المدني في الإسلام، ولا سيّما في كتابه «نظام الحكم في الإسلام»، حيث تظهر معالم هذا المجتمع بوضوح من خلال قراءته للتاريخ. لا يقصد بالمجتمع المدني هنا المعنى الغربي، بل مجتمعًا مكمّلًا للدولة. تفترض الورقة، استنادًا إلى عمل شمس الدين، إمكانيّة قيام علاقة تفاعليّة تكامليّة بين الدولة والمجتمع، تتجاوز العلاقة التقليديّة بين الحاكم والمحكوم، شرط تحقّق الشروط المدنيّة …

المسيحيّة في الكويت, محمد جاسم المحميد

Horizons et Conjonctures

خلاصة

يتناول البحث تاريخ المسيحيّين في الكويت منذ القرن العشرين، ولا سيّما مع الإرساليّين العرب–الأمريكيّين، كما يرصد أثر اكتشاف النفط على الوجود المسيحي في خمسينيّات وستّينيّات القرن الماضي. يدرس البحث العلاقة مع الفاتيكان والكنائس الثماني المعترف بها، مبرزًا واقع التعايش واحترام الدولة للحريّات الدستوريّة، ولا سيّما حرّيّة الاعتقاد. كما يشرح تأثير دخول الإسلام السياسي إلى البرلمان على حقوق المسيحيّين، مقارنةً بالدستور والاتفاقيّات الدوليّة، مبيّنًا دور المحكمة الدستوريّة في حماية الحقوق.‏

كلمات مفتاحيّة

المسيحيّة، الدستور، حقوق الإنسان، الإسلام السياسي‏

Résumé

L’article traite de l’histoire des chrétiens au Koweït depuis le XXe siècle et la Mission arabe-américaine, ainsi que de l’impact de …

الخروج من الهوامش إلى الدولة (رجال الدين الشيعة والحداثة اللبنانيّة 1920-1978), أحمد محسن

Horizons et Conjonctures

خلاصة

تمرّ هذه الأطروحة بثلاث فترات تأسيسيّة في تاريخ لبنان الحديث. الفترة الأولى هي فترة انهيار السلطنة العثمانيّة وانتقال لبنان إلى الحكم الفرنسيّ المباشر، ولا سيّما في جنوبه حيث يقع «جبل عامل» موضوع هذه الدراسة، أي رجال الدين المنتسبين إليه والخارجين عنه. أمّا الفترة الثانية فهي فترة الاستقلال اللبنانيّ وبداية ظهور المؤسّسات الإداريّة المنبثقة عن هذا الاستقلال. وأخيرًا، تمتدّ الفترة الثالثة إلى الربع الأوّل من الحرب الأهليّة اللبنانيّة.‏

A Taking By Any Other Name: Why Exclusionary Zoning Should Be Classified As A Per Se Taking, Matthew J. Ruppel

Seattle University Law Review Online

The housing affordability crisis in U.S. cities, particularly on the West Coast, has been well publicized in recent years, and the search for solutions has drawn together allies from across the ideological spectrum. While various cities and states have rolled out many types of reforms, there remains a widespread regulatory failure preventing the adaptation of cities to modern demands. A primary culprit is exclusionary zoning: plot-by-plot designation of which types of structures can be built on a piece of property— particularly which types of structures are absolutely prohibited from being built—and the broad definitional standards to which those structures must …

Jessy Mckee And Shayne Mackee, Appellants V. Clayton Mckeachine, Carolyn Harns, G&C Servi Es Inc., And Irene Mckee, Appellees : Brief Of Appellant, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Deborah R. Chandler, Attorneys for Burton and Christine Delambert, Stephen K. Christiansen, Anthony W. Steirling, Ryan R. Bolarder, Attorneys for Carolyn Harns, Kenneth J. Melrose, Attorney for Irene McKee, Clayton Mckeachnie, Pro Se, Kurt D. Reber, Attorneys for G&C Service, Inc

Deborah R. Chandler, Attorneys for Burton and Christine Delambert, Stephen K. Christiansen, Anthony W. Steirling, Ryan R. Bolarder, Attorneys for Carolyn Harns, Kenneth J. Melrose, Attorney for Irene McKee, Clayton Mckeachnie, Pro Se, Kurt D. Reber, Attorneys for G&C Service, Inc

Alan W. Dunaway, Attorneys for Appellants

Reliability Of Mpmri In Diagnosing Cancer Prostate Following Intravesical Bcg For Bladder Cancer, Arjun Ponavudaiappan, Pushan Prabhakar, Andrew Renshaw, Ahmed Eldefrawy, Murugesan Manoharan

All Publications

Background: Detecting carcinoma prostate (CaP) after intravesical Bacillus Calmette Guerin (BCG) immunotherapy for non-muscle invasive bladder cancer (NMIBC) poses diagnostic challenges. Granulomatous prostatitis (GP) has an incidence of 0.8%-3.3% in post-intravesical BCG patients and 6% incidence in a PIRADS 5 lesion on multiparametric MRI (mpMRI). Patients with GP after intravesical BCG may have clinical, biochemical, and radiological features similar to CaP. In our study, we evaluate the reliability of mpMRI in diagnosing CaP after intravesical BCG therapy.

Materials and methods: We reviewed the NMIBC patients treated with intravesical BCG therapy between 2017 and 2023 and investigated those who underwent mpMRI …

The Link October 15, 2024, Access To Justice Institute

The Link Newsletter

No abstract provided.

Knowledge Discovery Of Patients Reviews On Breast Cancer Drugs: Segmentation Of Side Effects Using Machine Learning Techniques, Mehrbakhsh Nilashi, Hossein Ahmadi, Rabab Ali Abumalloh, Mesfer Alrizq, Abdullah Alghamdi, Sultan Alyami

School of Nursing and Midwifery

Breast cancer stands as the most frequently diagnosed life-threatening cancer among women worldwide. Understanding patients' drug experiences is essential to improving treatment strategies and outcomes. In this research, we conduct knowledge discovery on breast cancer drugs using patients’ reviews. A new machine learning approach is developed by employing clustering, text mining and regression techniques. We first use Latent Dirichlet Allocation (LDA) technique to discover the main aspects of patients' experiences from the patients’ reviews on breast cancer drugs. We also use Expectation-Maximization (EM) algorithm to segment the data based on patients’ overall satisfaction. We then use the Forward Entry Regression …