Digital Commons Network^™

Secukinumab Treatment Response In Moderate-To-Severe Plaque Psoriasis: A Monocentric Retrospective Study, Benny Effendi Wiryadi, Yuriawati Hendrawan, Rini Herlina, Albertus Agung Mahode

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Psoriasis affects approximately 2% of the global population and is associated with comorbidities such as depression, psoriatic arthritis, and cardiometabolic syndrome. Secukinumab, a monoclonal antibody targeting interleukin-17A, is effective for moderate-to-severe plaque psoriasis. This study assessed the real-world effectiveness of secukinumab over 52 weeks.

Methods: This retrospective cohort study included 53 patients aged ≥18 years who received secukinumab and were followed for 52 weeks. Patients received weekly loading doses followed by maintenance injections every four weeks. Effectiveness was evaluated using changes in the Psoriasis Area and Severity Index (PASI).

Results: At week 16, 86.8% of patients achieved PASI <5, 79.2% PASI <3, 69.8% PASI <2, and 64.2% PASI <1, indicating substantial improvement. PASI 75 was achieved by 77.4% of patients at week 8. PASI 90 was achieved by 71.7% of all patients and by 76.9% of patients with psoriatic arthritis at week 16. No patients discontinued treatment because of adverse events.

Conclusion: …

Topical Normal Saline, Alcohol, And Petrolatum For Marsi: A Randomized Controlled Trial, Michael Hartanto Angriawan, Shannaz Nadia Yusharyahya, Rahadi Rihatmadja

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Medical adhesive-related skin injury (MARSI) is a common complication associated with acrylic-based adhesive removal. Topical agents such as 0.9% NaCl (normal saline), white petrolatum, and 70% alcohol are commonly used to assist adhesive removal; however, their effectiveness in reducing MARSI remains unclear.

Methods: This single-blind randomized controlled trial with a within-subject design included 56 healthy adults. Acrylic-based adhesives were applied to four sites on the upper arms. Adhesive removal was performed on days 3 and 6 using three interventions (normal saline, petrolatum, alcohol) and one control (no topical agent). Outcomes included MARSI incidence, clinical erythema score, erythema index, transepidermal …

Oral Tofacitinib For Recalcitrant Lichen Planus Pigmentosus: A Hospital-Based Retrospective Study, Rashmi Singh, Prachi Sharma, Rajnish Kumar, Mugdha Kulkarni, Tripti Upadhyay

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Cutaneous lichen planus (CLP) is a chronic inflammatory disease typically involving the flexor surfaces of the extremities. It is a CD8-positive T-cell-mediated disease of the skin in which an immune mechanism targets basal keratinocytes. Lichen planus pigmentosus (LPP), a variant of CLP, predominantly involves the extensor aspect and has recently been under the umbrella term of acquired dermal macular hyperpigmentation. The primary objective of our study was to determine the effectiveness of oral tofacitinib in treating LPP, and the secondary objective was to assess its safety.

Methods: Medical records of patients attending the Dermatology Outpatient Department between …

A Cross-Sectional Study At A Tertiary Setting Assessing Socioeconomic Burden And Psychological Impact Of Dermatophytoses, Amrita Hongal, Varsha Manchegowda, Mohan Hebbur Naraharirao, Mahalaxmi Khatagave, Rakshitha Nandeesh

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Dermatophytosis is a highly prevalent superficial fungal infection in tropical regions, often chronic due to inadequate treatment. Its recurrent nature due to misuse of topical steroids and inappropriate treatment contributes significantly to both financial burden and deterioration in quality of life. This article aimed to assess the socioeconomic burden and psychological impact of dermatophytosis, accounting for its chronicity.

Methods: This study included 285 patients aged ≥12 years with previously treated dermatophytosis. Data on demographics, disease characteristics, and treatment patterns were collected. Quality of life was assessed using the Dermatology Life Quality Index (DLQI) and the Short Form-36 (SF-36) questionnaire. …

Exploring Pediatric Leprosy In An Endemic Area: Case Series Of Eight Patients In Indonesia, Gitalisa Andayani Adriono, Tri Rahayu, Sri Linuwih Sw Menaldi, Nelfidayani Nelfidayani, Retno Sulistyo Wardani, Kahlil Gibran, Malika Sabrina Yunifananda, Kartika Qonita Putri, Yunia Irawati

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Leprosy remains a significant public health concern in endemic regions such as Indonesia. Children are particularly vulnerable due to their naive immunity and close familial contacts. This study aims to report cases of pediatric leprosy in Lembata, Indonesia, focusing on clinical characteristics and associated risk factors.

Case Illustration: A case series of eight pediatric patients (<15 >years) diagnosed with leprosy was conducted during a community-based screening program in Lembata, Indonesia, in 2022. Of 140 individuals examined, 8 were children. Most patients were male (6/8) with a mean age of 11.75 years. Multibacillary (MB) leprosy predominated (7/8), and a history …

Combination Therapy For Post-Acne Mandibular Keloid: Suprakeloidal Flap, Intralesional Triamcinolone, And Intense Pulsed Light, Miya Khalidah, Arief Budiyanto, Yohanes Widodo Wirohadidjojo, He Yeon Asva Nafaisa, Sonia Diovani, Dwinanda Almira Rizkiani, Dyah Ayu Mira Oktarina

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Keloid is a benign fibroproliferative skin disorder characterized by excessive collagen deposition resulting from abnormal wound healing that extends beyond the original wound margins. It is particularly challenging to treat, especially in areas with high mechanical tension and skin stiffness, such as the mandibular region, which is associated with increased risk of persistence and recurrence. Combination therapy has shown superior outcomes in reducing recurrence and improving keloids.

Case Illustration: A 41-year-old male with a post-acne keloid on his right mandible underwent surgical management using the suprakeloidal flap method followed by intralesional triamcinolone acetonide (TAC, 10 mg/mL, 20 mg) and …

Syphilis And Hiv Co-Infection Risk Factors At Dr. Moewardi Hospital, 2018–2022: A Retrospective Study, Endra Yustin Ellistasari, Prasetyadi Mawardi, Pratiwi Prasetya Primisawitri, Stella Gracia Octarica

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Treponema pallidum, the agent causing syphilis, is transmitted through contact with infectious lesions, bodily fluids, blood transfusions, or perinatally. Human immunodeficiency virus (HIV) infection can mask the clinical manifestations of syphilis, while syphilis may exacerbate HIV progression. This study aimed to analyze risk factors associated with HIV co-infection among patients with syphilis.

Methods: This retrospective, analytical, observational study reviewed medical records from the Dermatology and Venereology outpatient clinic at Dr. Moewardi Hospital, Surakarta, Indonesia, between January 2018 and December 2022. Demographic, behavioral, and clinical variables were extracted. Univariable analysis was performed using simple binary logistic regression to …

Lupus Vulgaris On The Left Arm Mimicking A Skin Tumor: A Case Report, Dwi Indria Anggraini, Nuriasani Yukendri, Indri Windarti

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Lupus vulgaris (LV) is a rare, paucibacillary form of post-primary cutaneous tuberculosis, accounting for 1.5% of all extrapulmonary tuberculosis cases globally. LV may arise via hematogenous spread, lymphatic route, or contiguous dissemination. The present case highlights the importance of considering LV in patients with chronic and atypical skin lesions, particularly in tuberculosis-endemic areas.

Case Illustration: A 17-year-old female presented with a 2-month history of a solitary, tender, erythematous nodule on the left arm. Initially suspected as a skin tumor, the lesion was surgically removed and tested for biopsy. One month postoperative, a new lesion developed precisely at the same …

Prognosis Of Early-Onset Alopecia Areata: An Evidence-Based Case Report, Sarah Qanita Edwar, Lili Legiawati, Stefani Reditya Anggraini, Ratu Siti Khadijah Sarah

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Alopecia areata (AA) is an autoimmune, non-scarring hair loss disorder commonly affecting children and often characterized by a chronic or relapsing course. Early-onset AA has traditionally been associated with a poorer prognosis, although current evidence remains inconclusive. This evidence-based case report aims to evaluate the prognostic significance of early-onset AA by synthesizing available cohort data.

Methods: A structured literature search was conducted in PubMed, EMBASE, Scopus, ProQuest, and Cochrane databases using a population, intervention, comparison, and outcome framework. Keywords included “alopecia areata”, “child”, “pediatrics”, “early-onset”, “recurrence”, and “prognosis”.

Results: Five retrospective cohort studies (n = 760) were included. …

Components Of Skin Boosters: A Therapeutic Role In Dermatologic Conditions, Ita Anggraini, Yuwandita Tamara Putri Dermawan, Eka Komarasari, Prima Kartika Esti

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: The term “skin booster” is commonly referred to in dermatology. These products may comprise several components, including exosomes, secretomes, chitosan, polydeoxyribonucleotide, platelet-rich plasma, and hyaluronic acid. In today’s world, the use of such products is not confined to aesthetic purposes; they are also used to treat several other skin conditions. This review paper highlights the role of “skin booster" components for different skin disorders based on their in vitro, in vivo, and clinical studies.

Discussion: “Skin boosters” are bioactive agents typically administered into the dermal layer. Understanding the mechanisms of each component is important because their applications extend beyond …

Molecular Identification Of Cryptococcus Albidus Isolated From A Gingivitis Infection In A Male From Karbala City, Iraq, Maysaa Taqi Al-Khazali, Zahraa Raheem Murshidy, Sarah Kadhim Al-Rahimy, Sura Abd Ali Kadhim Mohammed, Dhuha Ali Hussein

Karbala International Journal of Modern Science

The current study presents a case of gingivitis caused by Cryptococcus albidus in a 35-year-old male from the city of Karbala in Iraq. This fungal species was identified via morphology, microscopy, additionally to the VITEK system. C. albidus was further confirmed using the polymerase chain reaction (PCR) technique by amplifying the 18S rRNA gene as a universal primer and sequencing. Sequences analysis revealed that this strain of C. albidus had not been previously documented in the NCBI database. Hence, the newly obtained sequences were submitted to the GenBank repository and assigned the accession number OQ975882.1, marking the first report of …

Association Of Executive Function And Resilience With Psychological Well-Being Among Early Adolescents: A Case Study In Northern Thailand, Kanyawee Teerawan, Monrudee Chokprajakchad, Jumpee Granger, Siriporn Nirapun

Journal of Health Research

Background: In early adolescence, psychological well-being represents an important developmental outcome. This period is marked by significant physical, emotional, and psychosocial transitions. Widely recognized as protective factors, executive function and resilience contribute to positive adolescent adjustment and mental health. However, investigations on the roles of these constructs among early adolescents in Northern Thailand in research remains limited.

Method: This study employed a cross-sectional correlational design, using secondary data from 210 lower secondary school students aged 11 to 13 years in Northern Thailand. Validated self-report questionnaires were used to collect data by assessing executive function, resilience, and psychological well-being. Direct associations …

Persona Mailbox Auto-Provisioning With Credential Rehydration, Gustavo Matthew Assuncao

Defensive Publications Series

Multi-agent software platforms increasingly assign each autonomous AI agent ("persona") a first-class email identity so the agent can correspond like a human teammate. Doing this at scale exposes four under-addressed engineering problems: (1) provisioning APIs typically demand an explicit per-tenant domain setup step before any account exists, coupling agent creation to tenant onboarding; (2) an address must be synthesized deterministically and collision-safely from an agent's human-readable identity; (3) modern JMAP mail servers expose a provisioning-time account identifier distinct from the session-time account identifier used on the JMAP wire — conflating them silently breaks mail; and (4) the app-passwords minted during …

Multi-Provider Voice Pipeline With Lazy Key Routing, Gustavo Matthew Assuncao

Defensive Publications Series

Production voice-agent platforms typically hardcode their speech-to-text (STT) and text-to-speech (TTS) providers, and they read provider credentials from process environment variables at start-up. As a result, switching providers (or serving two tenants with different providers from a single process) requires a code change or a process restart, and it forces every tenant's secrets to coexist in one shared environment. This disclosure describes a real-time voice pipeline that removes those constraints through a specific combination of mechanisms: (1) each of the three pipeline stages — STT, brain language-model (LLM), and TTS — is resolved at call time by looking up a …

Proactive-Action Engine With Layered Cooldowns, Gustavo Matthew Assuncao

Defensive Publications Series

Autonomous AI agents are overwhelmingly reactive: they wait for an inbound trigger and act only in response, missing the proactive opportunities a competent human handles unbidden — an approaching deadline, a review gone stale, a recommended self-improvement, a teammate who has gone quiet. The naive countermeasure — "act every N minutes" — spams the agent's own queue, drowns urgent items, and wastes inference budget on duplicate nudges.

This publication describes a Proactive-Action Engine that closes the gap without the spam. On a configurable idle-scan interval, a single pass interrogates a plurality of heterogeneous signal sources — a deadline source, a …

Framing Tragedy: Discourse And Influence In Us Media Coverage Of The 1994 Rwanda Genocide, Andrew P. Young

Journal of 20th Century Media History

There is little doubt as to the mark left by the 1994 Rwandan genocide on historical discourse and perhaps even the American cultural consciousness. U.S. evening news broadcasts carried images of suffering and death into homes across the US, and in the process made Rwanda the site of one of the most recognized traumas in human history. While cultural proximity in mass media coverage played a role, the characterization of media coverage of the genocide, often defined in the press as explicit and constant, requires analysis. This project analyzes US evening network news broadcasts to address the actualities and implications …

[De]Constructing Jimmy's Grin: Doing Cultural Studies Through The Lens Of Boston Globe Editorial Cartoonist Paul Szep's Showcase Of Carter's White House Campaign, Lori Amber Roessner

Journal of 20th Century Media History

Heeding journalism historians Hanno Hardt and Bonnie Brennan’s call for inquiries that provide a new understanding of historical working conditions, this study explored the production of a sample of Szep’s editorial cartoons that surrounded Jimmy Carter’s campaign and presidency from 1976 to 1980. In particular, the manuscript considered the historical conditions and personal circumstances that influenced the cultural production of Szep’s body of work surrounding Jimmy Carter’s presidency; representations of Carter and his White House campaign in the sample of 20 editorial cartoons produced by Szep; moments of consumption by active Boston Globe audiences; the practice of identity [de]construction related …

Contested Bodies, Reconfigured Selves Rethinking Identity And Embodiment In Genai-Mediated Education, Anslem Böhmer

Journal of Academic Research and Innovation

No abstract provided.

The Ghostly Cyborg Author And The Living Reader Wonder, Supervision, And Scholarly Formation In The Age Of Ai, Connie Morrison, John L. Hoben

Journal of Academic Research and Innovation

No abstract provided.

Students' Supervision Amid An Ai Revolution Supervision, Ai Filtering And Human Proof-Reading, Daniel Rajmil, Pilar Ficapal-Cusí, Joan Torrent-Sellens

Journal of Academic Research and Innovation

No abstract provided.

Supervising In The Age Of Ai Cognitive Authenticity, And Reframing Integrity Through Neurodiversity-Responsive Perspective, Precious Nwanze

Journal of Academic Research and Innovation

No abstract provided.

From Gatekeeping To Cognitive Stewardship Rethinking Postgraduate Supervision In The Age Of Artificial Intelligence, Jon-Hans H. Coetzer Un, Erman Akilli Dr

Journal of Academic Research and Innovation

No abstract provided.

Human-Centred Generative Ai In Postgraduate Education Why Mediation, Calibration, And Contextual Flexibility Matter, Gabriela Zapata

Journal of Academic Research and Innovation

No abstract provided.

Who Cares In The Age Of Ai? Trust, Integrity & Compassion To Guide Education, Lia Pop

Journal of Academic Research and Innovation

No abstract provided.

Academic Integrity As A Socio-Technical System, Karlis Valtins

Journal of Academic Research and Innovation

No abstract provided.

Introducing Artificial Intelligence To The Metaverse, John O'Connor

Journal of Academic Research and Innovation

No abstract provided.

Artificial Intelligence - A Threat To Natural Intelligence? Fears, Concerns And Uncertainties Facing Educators In The 21st Century, Ivaylo Peev, Murat Gülmez, Anna Zherdeva, Lia Pop, Lucia Morales

Journal of Academic Research and Innovation

No abstract provided.

Broken Education Systems A Think Piece, Lucia Morales

Journal of Academic Research and Innovation

No abstract provided.

Foreword And Table Of Contents, Lucia Morales, Lia Pop, Ivaylo Peev, Murat Gülmez

Journal of Academic Research and Innovation

No abstract provided.

E1) Relics On The Move: Decentring Pilgrimage And The Mobility Of Holy Objects In Diaspora Communities, Dino Bozonelos, Daniel Vecchio

International Religious Tourism and Pilgrimage Conferences

Pilgrimage is frequently understood through a Western Christian framework, with the Camino de Santiago functioning as an archetypal model. As Coleman (2021) observes, this has encouraged scholars to apply Eurocentric definitions of pilgrimage to diverse religious practices, often obscuring alternative forms and limiting scholarly interpretation. Conventionally, pilgrimage requires religious travelers to leave home in search of the sacred what Victor Turner describes as the spiritual “out there “typically by journeying to a holy site associated with relics, idols, or images. However, such parameters exclude practices in which sacred objects themselves travel, bringing the “out there” home to devotees. In these …