Digital Commons Network^™

Inorganic Pyrophosphate Plasma Levels In Patients With Ggcx-Associated Pxe-Like Phenotypes, Qiaoli Li, Catherine Troutman, Mary Peckiconis, Tamara Wurst, Sharon Terry

Department of Biochemistry and Molecular Biology Faculty Papers

ntroduction: Pseudoxanthoma elasticum (PXE) is an autosomal recessive ectopic calcification disorder clinically affecting the skin, eyes, and vascular system. Most cases of PXE are caused by inactivating pathogenic variants in the ABCC6 gene encoding a hepatic transmembrane efflux transporter, which facilitates the extracellular release of ATP, the precursor of inorganic pyrophosphate (PPi), a potent endogenous inhibitor of calcification. Pathogenic variants in GGCX, encoding γ-glutamyl carboxylase required for activation of vitamin K-dependent coagulation factors as well as matrix Gla protein (MGP) and Gla-rich protein (GRP), two inhibitors of ectopic calcification, have also been reported to cause cutaneous changes like those seen …

Exploring Saliency Bias In Manipulation Detection, Joshua Krinsky, Alan Bettis, Qiuyu Tang, Daniel Moreira, Aparna Bharati

Computer Science: Faculty Publications and Other Works

The social media-fuelled explosion of fake news and misinformation supported by tampered images has led to growth in the development of models and datasets for image manipulation detection. However, existing detection methods mostly treat media objects in isolation, without considering the impact of specific manipulations on viewer perception. Forensic datasets are usually analyzed based on the manipulation operations and corresponding pixel-based masks, but not on the semantics of the manipulation, i.e., type of scene, objects, and viewers’ attention to scene content. The semantics of the manipulation play an important role in spreading misinformation through manipulated images. In an attempt to …

Multi-Agent System-Based Framework For An Intelligent Management Of Competency Building, Fatma Outay, Nafaa Jabeur, Fahmi Bellalouna, Tasnim Al Hamzi

All Works

To measure the effectiveness of learning activities, intensive research works have focused on the process of competency building through the identification of learning stages as well as the setup of related key performance indictors to measure the attainment of specific learning objectives. To organize the learning activities as per the background and skills of each learner, individual learning styles have been identified and measured by several researchers. Despite their importance in personalizing the learning activities, these styles are difficult to implement for large groups of learners. They have also been rarely correlated with each specific learning stage. New approaches are, …

Usf2 And Tfeb Compete In Regulating Lysosomal And Autophagy Genes, Jaebeom Kim, Young Suk Yu, Yehwa Choi, Do Hui Lee, Soobin Han, Junhee Kwon, Taichi Noda, Masahito Ikawa, Dongha Kim, Hyunkyung Kim, Andrea Ballabio, Keun Il Kim, Sung Hee Baek

Duncan NRI Faculty and Staff Publications

Autophagy, a highly conserved self-digestion process crucial for cellular homeostasis, is triggered by various environmental signals, including nutrient scarcity. The regulation of lysosomal and autophagy-related processes is pivotal to maintaining cellular homeostasis and basal metabolism. The consequences of disrupting or diminishing lysosomal and autophagy systems have been investigated; however, information on the implications of hyperactivating lysosomal and autophagy genes on homeostasis is limited. Here, we present a mechanism of transcriptional repression involving upstream stimulatory factor 2 (USF2), which inhibits lysosomal and autophagy genes under nutrient-rich conditions. We find that USF2, together with HDAC1, binds to the CLEAR motif within lysosomal …

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

A Dosimetric Comparison Of Treatment Techniques For Stereotactic Body Radiotherapy For Pancreatic Patients, Kameron Lemley

Masters Projects

Stereotactic body radiotherapy (SBRT) is utilized in radiation therapy to deliver ablative radiation doses to tumor volumes while achieving high conformity and minimal dose to surrounding critical structures. This treatment technique allows for faster dose fall-off which allows tighter treatment margins. SBRT for pancreatic cancer has been investigated for its efficacy and has proven to be an effective treatment choice for neoadjuvant radiation therapy. Since pancreatic cancer is extremely aggressive with a high mortality rate, it is important to have a treatment option that can reduce cost and increase convenience for the patient while simultaneously providing a conformal treatment plan. …

Neuronal Alpha-Synuclein Disease Integrated Staging System Performance In Ppmi, Pasadena, And Spark Baseline Cohorts, Tien Dam, Gennaro Pagano, Michael C Brumm, Caroline Gochanour, Kathleen L Poston, Daniel Weintraub, Lana M Chahine, Christopher Coffey, Caroline M Tanner, Catherine M Kopil, Yuge Xiao, Sohini Chowdhury, Luis Concha-Marambio, Peter Dibiaso, Tatiana Foroud, Mark Frasier, Danna Jennings, Karl Kieburtz, Kalpana Merchant, Brit Mollenhauer, Thomas J Montine, Kelly Nudelman, John Seibyl, Todd Sherer, Andrew Singleton, Diane Stephenson, Matthew Stern, Claudio Soto, Eduardo Tolosa, Andrew Siderowf, Billy Dunn, Tanya Simuni, Kenneth Marek, Parkinson’S Progression Markers Initiative Collaborators

Faculty, Staff and Student Publications

The Neuronal alpha-Synuclein Disease (NSD) biological definition and Integrated Staging System (NSD-ISS) provide a research framework to identify individuals with Lewy body pathology and stage them based on underlying biology and increasing degree of functional impairment. Utilizing data from the PPMI, PASADENA, and SPARK studies, we developed and applied biologic and clinical data-informed definitions for the NSD-ISS across the disease continuum. Individuals enrolled as Parkinson's disease, Prodromal, or Healthy Controls were defined and staged based on biological, clinical, and functional anchors at baseline. Across the three studies 1741 participants had SAA data and of these 1030 (59%) were S+ consistent …

Spatial Organization Of Adenylyl Cyclase And Its Impact On Dopamine Signaling In Neurons, Léa Ripoll, Yong Li, Carmen W Dessauer, Mark Von Zastrow

Faculty, Staff and Student Publications

The cAMP cascade is increasingly recognized to transduce physiological effects locally through spatially limited cAMP gradients. However, little is known about how adenylyl cyclase enzymes that initiate cAMP gradients are localized. Here we address this question in physiologically relevant striatal neurons and investigate how AC localization impacts downstream signaling function. We show that the major striatal AC isoforms are differentially sorted between ciliary and extraciliary domains of the plasma membrane, and that one isoform, AC9, is uniquely concentrated in endosomes. We identify key sorting determinants in the N-terminal cytoplasmic domain responsible for isoform-specific localization. We further show that AC9-containing endosomes …

Understanding Necrotizing Enterocolitis Endotypes And Acquired Intestinal Injury Phenotypes From A Historical And Artificial Intelligence Perspective., Alain Cuna, Navin Kumar, Venkatesh Sampath

Manuscripts, Articles, Book Chapters and Other Papers

Necrotizing enterocolitis (NEC) remains a devastating disease in preterm and term neonates. Despite significant progress made in understanding NEC pathogenesis over the last 50 years, the inability of current definitions to discriminate the various pathophysiological processes underlying NEC has led to an umbrella term that limits clinical and research progress. In this mini review, we provide a historical perspective on how NEC definitions and pathogenesis have evolved to our current understanding of NEC endotypes. We also discuss how artificial intelligence-based approaches are influencing our knowledge of risk-factors, classification and prognosis of NEC and other neonatal intestinal injury phenotypes.

Mtap And P16 Ihc As Markers For Cdkn2a/B Loss In Meningiomas, Hanim I Ozkizilkaya, Anjali Vinocha, Antonio Dono, Oluwaseun Basit Ogunbona, Gokce A Toruner, Phyu P Aung, Carlos Kamiya Matsuoka, Yoshua Esquenazi, Franco Demonte, Leomar Y Ballester

Faculty, Staff and Student Publications

Background: Homozygous cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) loss is one of the parameters that support the designation of meningiomas as Central Nervous System (CNS) WHO grade 3 tumors. Evaluation of CDKN2A/B by sequencing or Fluorescence in situ hybridization (FISH) is costly and not always readily accessible. An immunohistochemistry (IHC)-based marker for the evaluation of CDKN2A/B loss would provide faster results at a lower cost.

Methods: This retrospective study included patients diagnosed with meningioma at our institution between 2016 and 2019. Archival tumor tissue was used for analysis. MTAP immunohistochemistry (IHC) was performed at various dilutions (1:1200, 1:400, 1:200, 1:100) using …

Consulting Ss, Inc. V. Mckellar

All Decisions

AT2 consolidated three appeals by the same landlord, who sought to evict tenants from a basement apartment and two SRO units, claiming the building was a two-family dwelling and not rent-stabilized. Each tenant argued the building had seven residential units—one apartment and six SROs—making it subject to rent stabilization. The lower court agreed with the tenants, granting summary judgment due to the landlord's failure to serve required statutory termination notices. The Appellate Term affirmed, ruling that the building’s rent stabilization status depends on the units’ function as residences, regardless of their legality under a certificate of occupancy.

Consulting Ss, Inc. V. Faison

All Decisions

AT2 consolidated three appeals by the same landlord, who sought to evict tenants from a basement apartment and two SRO units, claiming the building was a two-family dwelling and not rent-stabilized. Each tenant argued the building had seven residential units—one apartment and six SROs—making it subject to rent stabilization. The lower court agreed with the tenants, granting summary judgment due to the landlord's failure to serve required statutory termination notices. The Appellate Term affirmed, ruling that the building’s rent stabilization status depends on the units’ function as residences, regardless of their legality under a certificate of occupancy.

2024-2025 Performance Forum - September 27, 2024, Caroline Dratnal, Sheng Yuan Kuan, Devin Salazar, Yu-Hsuan Feng, Yilian Concepcion, Jon Cruz, Juan Diaz Quijano, Paula Mora Alfaro

Performance Forum

No abstract provided.

Rotational Machine Fault Diagnosis Using Artificial Intelligence (Ai) Strategies For The Operational Challenges Under Variable Speed Condition: A Review, S. Sowmya, M. Saimurugan, Immanuel A. Edinbarough

Informatics and Engineering Systems Faculty Publications

Rotational machines in industries often encounter uncertainties during operation, are monitored and diagnosed through machine condition monitoring. Particularly when speed varies, Artificial Intelligence (AI) provides a great deal of support in recognizing machine faults efficiently. This paper reviews various articles that focused on fault identification in industrial rotating machines under varying speed condition using AI techniques. It investigates various machinery faults, experimental datasets and reputed institutions datasets, complex signals from faulty components and their processing method. Further, the involvement of intelligent based techniques in extracting and selecting suitable features to classify defects are comprehensively reviewed. In addition, as multi-signal fusion …

Use Of Web-Based Decision Support To Improve Informed Choice For Chemoprevention: A Qualitative Analysis Of Pre-Implementation Interviews (Swog S1904), Alissa M Michel, Haeseung Yi, Jacquelyn Amenta, Nicole Collins, Anna Vaynrub, Subiksha Umakanth, Garnet Anderson, Katie Arnold, Cynthia Law, Sandhya Pruthi, Ana Sandoval-Leon, Rachel Shirley, Maria Grosse Perdekamp, Sarah Colonna, Stacy Krisher, Tari King, Lisa D Yee, Tarah J Ballinger, Christa Braun-Inglis, Debra A Mangino, Kari Wisinski, Claudia A Deyoung, Masey Ross, Justin Floyd, Andrea Kaster, Lindi Vanderwalde, Thomas J Saphner, Corrine Zarwan, Shelly Lo, Cathy Graham, Alison Conlin, Kathleen Yost, Doreen Agnese, Cheryl Jernigan, Dawn L Hershman, Marian L Neuhouser, Banu Arun, Katherine D Crew, Rita Kukafka

Faculty, Staff and Student Publications

Background: Women with high-risk breast lesions, such as atypical hyperplasia (AH) or lobular carcinoma in situ (LCIS), have a 4- to tenfold increased risk of breast cancer compared to women with non-proliferative breast disease. Despite high-quality data supporting chemoprevention, uptake remains low. Interventions are needed to break down barriers.

Methods: The parent trial, MiCHOICE, is a cluster randomized controlled trial evaluating the effectiveness and implementation of patient and provider decision support tools to improve informed choice about chemoprevention among women with AH or LCIS. For this pre-implementation analysis, 25 providers participated in semi-structured interviews prior to accessing decision support tools. …

2024 - Faculty & Staff Research Symposium, Elizabeth Outka, Lidia Radi

Faculty and Staff Research Symposium Programs

[Excerpt from the "Welcome"]

"Dear Colleagues,

Welcome to the second Faculty and Staff Research Symposium!

We are delighted to see such enthusiasm for this event, following the extraordinary response to last year’s inaugural Symposium. It is truly a testament to the vibrant, engaged community we have here — a group of colleagues deeply committed to ideas, creativity, and collaboration. Across our campus, faculty and staff continue to push the boundaries of research, to design and maintain new learning and gathering spaces, to craft remarkable art and performances, and to develop innovative programs that enrich our collective experience. . . . …

Faculty Advisory Committee Minutes Of The Academic Senate 2024-09-27, University Of Dayton. Faculty Affairs Committee

All Committee Minutes

Approved minutes of a meeting of the Faculty Affairs Committee of the Academic Senate of the University of Dayton.

Butte Priority Soils Operable Unit (Bpsou) Butte Hill Revegetation Specifications (Bhrs), Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Sga 56 Senate 2024-09-27 Minutes, Niu Student Government Association Senate

Student Government Association Archives

No abstract provided.

Investigating The Role Of Mental Imagery Use In The Assessment Of Anhedonia, Julie L Ji, Marcella L Woud, Angela Rölver, Lies Notebaert, Jemma Todd, Patrick J F Clarke, Frances Meeten, Jürgen Margraf, Simon E Blackwell

School of Psychology

Anhedonia, or a deficit in the liking, wanting, and seeking of rewards, is typically assessed via self-reported "in-the-moment" emotional and motivational responses to reward stimuli and activities. Given that mental imagery is known to evoke emotion and motivational responses, we conducted two studies to investigate the relationship between mental imagery use and self-reported anhedonia. Using a novel Reward Response Scale (adapted from the Dimensional Anhedonia Rating Scale, DARS; Rizvi et al., 2015) modified to assess deliberate and spontaneous mental imagery use, Study 1 ( N  = 394) compared uninstructed and instructed mental imagery use, and Study 2 ( N  = …

Re: Butte Mine Flooding Operable Unit Berkeley Pit And Discharge Pilot Project – August 2024 Monthly Discharge Monitoring Report, Mark Thompson, Dave Griffis

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Cover And Contents

Turkish Journal of Earth Sciences

No abstract provided.

An Archaeological And Archaeoseismological Perspective On Earthquakes In The Coastal Cities Of Western Anatolia In The 3rd Millennium Bce: Settlement Abandonment And Changes In Social Structures, Ümi̇t Gündoğan

Turkish Journal of Earth Sciences

This study investigates the impact of the earthquakes that occurred in the first half of the 3rd millennium BCE on Western Anatolian settlements, aiming to determine the dates of the earthquakes that happened during the prehistoric period using the earthquake layers of the settlements and associated C14 data. The focus of the paper is the investigation of the effects of two earthquakes that occurred in the region during the first half of the 3rd millennium BCE on the settlements of the region. The first earthquake occurred around 2800 BCE and damaged settlements in the area of İzmir. Evidence of this …

Sequence Stratigraphy And Hydrocarbon Potential Of The Paleozoic Successions On The Arabian Platform And Southeast Türkiye, Muhi̇tti̇n Şenalp, Sema Teti̇ker

Turkish Journal of Earth Sciences

In 1989, the first prolific hydrocarbon reservoirs were discovered by Saudi Aramco in the highly porous and permeable friable continental sandstones (Unayzah reservoirs) and shallow marine carbonates (Khuff reservoirs) of the Paleozoic successions in south of Riyadh, Central Arabia. These successions were strongly affected by tectonic movements (Caledonian and Hercynian orogenesis) and Early and Late Paleozoic Gondwana glaciations. Therefore, some sections were fully eroded or significantly reduced in their thickness. The sequence stratigraphic interpretation of the Paleozoic successions helped to understand the depositional environments and regional distribution of the source, reservoir and cap rock facies in an improved palynologic studies. …

Assessment Of Water Pollution In A Waste Storage Drainage Area (A Case Study In Eskişehir, Türkiye), Ali̇ Kayabaşi, Özlem Toygar Sağin, Candan Gökçeoğlu

Turkish Journal of Earth Sciences

Before 2016, the Eskişehir city landfill was an irregular landfill. Since then, it has been transformed into a regulated landfill. This study aimed to investigate the presence of pollution in the landfill drainage area. For this purpose, water samples were collected from the landfill drainage area and the Kadirbey Farm Spring, upstream of the landfill area, during the rainy and dry seasons of 2021. Analyses of the heavy metal content, total dissolved soil (TDS), chemical oxygen demand, biochemical oxygen demand, pH, phenol material content, ammonia nitrogen content, and conductivity were conducted on the samples. Electrical resistivity tomography (ERT) measurements were …

Top To Bottom Interactive Velocity Analysis Using Travel-Time Ellipses And First Break Times From Walkaway Vertical Seismic Profiling Data: A Synthetic Study, Cemal Erdemi̇r

Turkish Journal of Earth Sciences

An interactive velocity analysis method is introduced in this paper and its efficacy is tested on various walkaway vertical seismic profile (WVSP) modeled data sets. In WVSP surveys, interval velocity profiles are determined fairly accurately along the VSP borehole using first break travel time picks from the zero-offset VSP (ZVSP) data. However the accuracy of these vertical velocities fade away quickly as the source distance (offset) from the VSP borehole increases due to possible horizontal changes in the geology or dips of the horizons. If the layer boundaries are not known, a simple approach type of ray tracing using horizontally …

Celebrating Success, Part 5, September 27, 2024, Tisa Mason Ed.D.

Heart of a Tiger Columns

No abstract provided.

The Association Of The Oral Microbiota With Cognitive Functioning In Adolescence, Oxana Y Naumova, Pavel V Dobrynin, Galina V Khafizova, Elena L Grigorenko

Faculty, Staff and Students Publications

Background: A growing body of research supports the role of the microbial communities residing in the digestive system in the host's cognitive functioning. Most of these studies have been focused on the gut microbiome and its association with clinical phenotypes in middle-aged and older adults. There is an insufficiency of population-based research exploring the association of normative cognitive functioning with the microbiome particularly with the oral microbiota.

Methods: In this study, using metagenomics and metabolomics, we characterized the salivary microbiome diversity in a sample of 51 males of Hispanic and African American origin aged 12-18 years and explored …

A Basally Active Cgas-Sting Pathway Limits Sars-Cov-2 Replication In A Subset Of Ace2 Positive Airway Cell Models, Maritza Puray-Chavez, Jenna E Eschbach, Ming Xia, Kyle M Lapak, Qianzi Zhou, Ria Jasuja, Jiehong Pan, Jian Xu, Zixiang Zhou, Shawn Mohammed, Qibo Wang, Dana Q Lawson, Sanja Djokic, Gaopeng Hou, Siyuan Ding, Steven L Brody, Michael B Major, Dennis Goldfarb, Sebla B Kutluay

2020-Current year OA Pubs

Host factors that define the cellular tropism of SARS-CoV-2 beyond the cognate ACE2 receptor are poorly defined. Here we report that SARS-CoV-2 replication is restricted at a post-entry step in a number of ACE2-positive airway-derived cell lines due to tonic activation of the cGAS-STING pathway mediated by mitochondrial DNA leakage and naturally occurring cGAS and STING variants. Genetic and pharmacological inhibition of the cGAS-STING and type I/III IFN pathways as well as ACE2 overexpression overcome these blocks. SARS-CoV-2 replication in STING knockout cell lines and primary airway cultures induces ISG expression but only in uninfected bystander cells, demonstrating efficient antagonism …

How Do You Like Your Books, Jessica Silbey

Faculty Scholarship

Do you ever wonder how it is that libraries can lend books repeatedly, while copyright owners (e.g., book authors) are granted the exclusive right to distribute their copyrighted works? Or how publishers make money selling books at retail prices when a person can resell books (or buy used books) for much less (hello Amazon Used Books for under a dollar!)? The reason is because of copyright’s “first sale” doctrine, 17 U.S.C. § 109, codifying the common law’s exhaustion principle, which says owners of lawfully made copies are allowed to dispose of those copies without regard to copyright law. In other …