Digital Commons Network^™

Efficacy And Safety Of Glp-1 Analog Ecnoglutide In Adults With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial, Dalong Zhu, Weimin Wang, Guoyu Tong, Guoqing Ma, Jianhua Ma, Jie Han, Xin Zhang, Yang Liu, Shenglian Gan, Hong Qin, Qing Zheng, Jing Ning, Zhiyi Zhu, Mengying Guo, Yue Bu, Yao Li, Catherine L Jones, Martijn Fenaux, Mohammed K Junaidi, Susan Xu, Hai Pan

Faculty, Staff and Student Publications

Glucagon-like peptide-1 (GLP-1) analogs are important therapeutics for type 2 diabetes and obesity. Ecnoglutide (XW003) is a novel, long-acting GLP-1 analog. We conducted a Phase 2, randomized, double-blind, placebo-controlled study enrolling 145 adults with T2DM. Participants were randomized to 0.4, 0.8, or 1.2 mg ecnoglutide or placebo as once-weekly injections for 20 weeks. The primary objective was to evaluate the efficacy of ecnoglutide, as measured by HbA1c change from baseline at Week 20. Secondary endpoints included body weight, glucose and lipid parameters, as well as safety. We show that, at end of treatment, the 0.4, 0.8, and 1.2 mg groups …

Fatigue-Resistant Mechanoresponsive Color-Changing Hydrogels For Vision-Based Tactile Robots, Jiabin Liu, Wei Li, Yu She, Sean Blanchard, Shaoting Lin

School of Industrial Engineering Faculty Publications

Mechanoresponsive color-changing materials that can reversibly and resiliently change color in response to mechanical deformation are highly desirable for diverse modern technologies in optics, sensors, and robots; however, such materials are rarely achieved. Here, a fatigue-resistant mechanoresponsive color-changing hydrogel (FMCH) is reported that exhibits reversible, resilient, and predictable color changes under mechanical stress. At its undeformed state, the FMCH remains dark under a circular polariscope; upon uniaxial stretching of up to six times its initial length, it gradually shifts its color from black, to gray, yellow, and purple. Unlike traditional mechanoresponsive color-changing materials, FMCH maintains its performance across various strain …

Molecular Architecture Of Chitin And Chitosan-Dominated Cell Walls In Zygomycetous Fungal Pathogens By Solid-State Nmr, Qinghui Cheng, Malitha C. Dickwella Widanage, Jayasubba Reddy Yarava, Ankur Ankur, Jean Paul Latgé, Ping Wang, Tuo Wang

School of Medicine Faculty Publications

Zygomycetous fungal infections pose an emerging medical threat among individuals with compromised immunity and metabolic abnormalities. Our pathophysiological understanding of these infections, particularly the role of fungal cell walls in growth and immune response, remains limited. Here we conducted multidimensional solid-state NMR analysis to examine cell walls in five Mucorales species, including key mucormycosis causative agents like Rhizopus and Mucor species. We show that the rigid core of the cell wall primarily comprises highly polymorphic chitin and chitosan, with minimal quantities of β-glucans linked to a specific chitin subtype. Chitosan emerges as a pivotal molecule preserving hydration and dynamics. Some …

Selected U.S. Government Statistical Agencies And Their Data, Bert Chapman

Libraries Faculty and Staff Presentations

Provides introductory and detailed overview of U.S. Government agencies statistics. Includes examples of how an individual U.S. law authorizes government agencies to compile statistics for particular congressional committees and the general public. Statistics cover topics such as demography, defense, foreign assistance, economic growth, criminal justice, energy, Social Security, and Medicare.

Genomic And Socioeconomic Determinants Of Racial Disparities In Breast Cancer Survival: Insights From The All Of Us Program, Nubaira Rizvi, Hui Lyu, Leah Vaidya, Xiao Cheng Wu, Lucio Miele, Qingzhao Yu

School of Public Health Faculty Publications

Background: Breast cancer outcomes are worse among Black women in the U.S. compared to White women. While extensive research has focused on risk factors contributing to breast cancer; the role of genomic elements in health disparities between these racial groups remains unclear. This study aims to identify genomic variants and socioeconomic status (SES) determinants influencing racial disparities in breast cancer survival through multiple mediation analyses. Methods: Our investigation is based on the NIH-supported All of Us (AoU) program and analyzes 7452 female participants with malignant tumors of breast, including 5073 with genomic data. A log-rank test reveals significant racial differences …

“What Keeps Me In School”: Oregon Bipoc Learners Voice Support That Makes Higher Education Possible, Roberta Hunte, Miranda Mosier-Puentes, Gita Mehrotra, Eva Skuratowicz

School of Social Work Faculty Publications and Presentations

A growing number of college students are nontraditional learners (age 21–65) who are people of color. These students face unique challenges in a higher education system increasingly shaped by neoliberalism and the ongoing context of institutionalized racism. In Oregon, policymakers have established ambitious goals to address racial disparities in educational attainment. In this study, focus groups and interviews were conducted with 111 Black, Indigenous, and People of Color (BIPOC) adult learners in Oregon to better understand their perspectives and experiences in regard to educational and career pathways. Participants included currently enrolled students, adults who had enrolled and left, and adults …

Hawc Observations Of Microquasars As Powerful Particle Accelerators, Xiaojie Wang, Xiaojie Wang, Dezhi Huang, Dezhi Huang, Chang Dong Rho, A. Albert, R. Alfaro, C. Alvarez, A. Andrés, J. C. Arteaga-Velázquez, D. Avila Rojas, H. A. Ayala Solares, R. Babu, E. Belmont-Moreno, T. Capistrán, Y. Cárcamo, A. Carramiñana, F. Carreón

Physics Faculty Research & Creative Works

Micro quasars are one of the classes of powerful Galactic particle accelerators that emit gamma rays beyond multi-TeV energies. Recently, gamma-ray emission above tens of TeV has been detected from some of these objects. The High-Altitude Water Cherenkov (HAWC) observatory has previously reported gamma-ray emission with a median energy of 25 TeV from the micro quasar SS 433, suggesting that gamma-ray binaries can accelerate particles to above 100 TeV inside the jets. With 2,321 days of data and better reconstruction algorithms, the HAWC observatory detected emissions above 20 TeV from two other binaries, V4641 Sagittarii and LS 5039. The V4641 …

Manganese Sulfanyl Porphyrazine–Mwcnt Nanohybrid Electrode Material As A Catalyst For H2o2 And Glucose Biosensors, Michal Falkowski, Amanda Leda, Mina Hassani, Michal Wicinski, Dariusz T. Mlynarczyk, Nejat Düzgüneş, Michal P. Marszall, Grzegorz Milczarek, Jaroslaw Piskorz, Tomasz Rębiś

Pacific Faculty Work

The demetallation reaction of sulfanyl magnesium(II) porphyrazine with N-ethylphthalimide substituents, followed by remetallation with manganese(II) salts, yields the corresponding manganese(III) derivative (Pz3) with high efficiency. This novel manganese(III) sulfanyl porphyrazine was characterized by HPLC and analyzed using UV-Vis, MS, and FT-IR spectroscopy. Electrochemical experiments of Pz3 conducted in dichloromethane revealed electrochemical activity of the new complex due to both manganese and N-ethylphthalimide substituents redox transitions. Subsequently, Pz3 was deposited on multiwalled carbon nanotubes (MWCNTs), and this hybrid material was then applied to glassy carbon electrodes (GC). The resulting hybrid electroactive electrode material, combining manganese(III) porphyrazine with MWCNTs, showed a significant …

Antibacterial Activities And Chemical Composition Of Essential Oils From Sweet Orange (Citrus Sinensis), Lemon Grass (Cymbopogon Citratus), And Lime (Citrus Aurantifolia) Peels, Olumide Omoboye, Toyosi Sotola, Olaoye Balogun, Ololade Bamigbade, Olusola Oluwole, Adebowale Odeyemi, Anthonia Oluduro

Makara Journal of Science

This study investigated the chemical composition and antibacterial activities of lime Citrus aurantifolia (Cc) and lemon grass Cymbopogon citratus (Ca) essential oils (EOs). Standard methods were used to determine their minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC), and gas chromatography–mass spectrometry was used to determine their composition. Each EO and their combination showed promising results in treating test bacterial infections. Cc EO showed the largest inhibition zone diameter (43 mm) against Staphylococcus aureus and Serratia marcescens, and Ca EO showed the largest (30 mm) and smallest (12 mm) inhibition zone diameters against Bacillus stearothermophilus and S. marcescens …

Polyvinyl Alcohol–Red Cabbage Nanofibers As Ph-Responsive Freshness Sensors For Advanced Food Packaging Technology, Foliatini Foliatini, Singgih Wibowo, Henny Rochaeni, Suhartini Suhartini, Fachrurrazie Fachrurrazie, Arzzaq Imanda Prianditya, Pradnadia Putri Hadriansyah, Naura Athira Putri Siregar, Novi Nurpadilah, Putri Alfiani, Maudi Rahim, Endah Sriwahyuni

Makara Journal of Science

The development of innovative food packaging technologies, particularly those capable of monitoring freshness, has become increasingly important in the food industry. This research explores the development of a pH-responsive freshness sensor using polyvinyl alcohol–red cabbage (PVA/RC) nanofibers. The nanofibers are fabricated through the electrospinning technique and meticulously analyzed via scanning electron microscopy, Fourier-transform infrared (FTIR) spectroscopy, and differential scanning calorimetry (DSC). The results underscore the fine structure of the nanofiber matrix, with an average diameter of ~68 nm. FTIR analysis substantiates the presence of anthocyanin compounds from RC within the PVA/RC nanofibers, which confirms the integration of beneficial components into …

Preliminary Molecular Study Of Chloramphenicol Anchoring On Laccase Enzyme From Trametes Hirsuta, Hanzhola Gusman Riyanto, Afiten Rahmin Sanjaya

Makara Journal of Science

Antibiotics are one of emerging pollutants generally emitted from livestock production and the food industry to the environment. The presence of this pollutant could initiate the development of resistant bacteria that can be fatal to human health. The degradation of antibiotics using enzymes or microbe could be an alternative because the residue or intermediate product is less harmful than of the conventional method. This research aims to support a preliminary study of the degradation of antibiotics using enzyme through molecular docking via Molecular Operating Environment software and molecular dynamics (MD) study via CABSFLEX 2.0 and WebGro macromolecular simulations. The molecular …

Evaluation Of The Water Quality And Distribution Of Heavy Metals In The Gomti River Flowing Through The Urban Region Of Lucknow, India, Neha Gondial, Sandhya Bharti

Makara Journal of Science

The physicochemical properties and heavy metals contents of the Gomti River water (GRW) samples collected from five selected sites covering a stretch of ~31 km in Lucknow, Uttar Pradesh, India were ascertained. The sites were Ghaila Pul, Mehndi Ghat, Shaheed Smarak, Kukrail Junction, and Bande Dam, represented as S1, S2, S3, S4, and S5, respectively, following from upstream to downstream. S1 was considered as a reference site. The values of pH, temperature, total dissolved solids (TDS), electrical conductivity (EC), turbidity, dissolved oxygen (DO), biochemical oxygen demand (BOD), total hardness (TH), total chloride (TC), total alkalinity (TA), total acidity (TAC), total …

Detecting Edges Of Geologic Sources From Gravity Or Magnetic Anomalies Through A Novel Algorithm Based On Hyperbolic Tangent Function, Hanbing Ai, Yunus Levent Eki̇nci̇, Ahmad Alvandi, Hazel Deni̇z Toktay, Çağlayan Balkaya, Arka Roy

Turkish Journal of Earth Sciences

Directional derivative-based edge detectors are commonly used to outline the abrupt lateral variations in densities or magnetizations of geologic sources from potential-field datasets. Some subtle traces of faults, lithological contacts, and lineaments can be made more visible on anomaly maps using these algorithms. However, these algorithms generally suffer from common limitations such as blurry edges with low-resolution or faulty boundaries. To minimize these challenges, we proposed a new efficient edge detector that benefits from the hyperbolic tangent function. The performance of this detector was tested on the responses of a synthetic gravity model and Bishop's complex magnetic model. A Gaussian …

Utility Of Individualised Homoeopathic Medicines In Improving Social Interaction In Childhood Autism: A Prospective, Open-Label, Single Arm Study, Sreeja Kudukayil Radhakrishnan Nair, Deepthi Gilla, Mohan Narvelil Devasia

Indian Journal of Research in Homoeopathy

Background: Childhood autism is a pervasive developmental disorder. There has been an upsurge in its prevalence in past few decades. The social deficit is the most disabling symptom of autism. There is an immediate need to explore new interventions to effectively address childhood autism. Objective: The objective of the study was to assess the usefulness of individualised homoeopathic medicine in improving social interaction in childhood autism. Materials and Methods: This one-year duration study was conducted in the outpatient department of the National Homoeopathy Research Institute in Mental Health, Kottayam, Kerala. Thirty-five children fulfilling the diagnostic criteria of childhood autism (as …

Book Review On "Homeopathy For Farm And Garden", Hima Bindu Ponnam

Indian Journal of Research in Homoeopathy

Book review on "Homeopathy for Farm and Garden"

A Novel Model Of Autologous Tooth Transplantation For The Study Of Nerve Recruitment, Teresa E. Fowler, Doan T. Bloomquist, Caroline Glessner, Poonam Patel, Jeffrey N. James, Kathryn Bollinger, Lynnette P. Mccluskey, Ryan F. Bloomquist

School of Dentistry Faculty Publications

Background: Limited treatment options exist for damaged nerves and despite impressive advances in tissue engineering, scientists and clinicians have yet to fully replicate nerve development and recruitment. Innervation is a critical feature for normal organ function. While most organs are innervated prior to birth, a rare example of postnatal nerve recruitment occurs in the natural development of secondary teeth during adolescence. Many animals undergo postnatal shedding of deciduous teeth with development and eruption of secondary teeth, a process requiring recruitment of nerve and vasculature to each tooth pulp for viability. Here, the investigators created a novel model for the study …

The Prognostic Significance Of Androgen Receptor Expression In Gliomas, Chi Zhang, Nan Zhao, Rubayat Khan, Ming-Yang Hung, Chi Zhang, Shuo Wang, Tony J.C. Wang, Chi Lin

School of Biological Sciences: Faculty Publications

Androgen receptor (AR) overexpression has been identified in gliomas and its stem cells, suggesting that AR plays an important role in tumor carcinogenesis. The prognostic significance of AR overexpression in gliomas remains unknown. AR mRNA expression in gliomas and relevant clinical data were obtained from The Cancer Genome Atlas and Chinese Glioma Genome Atlas databases. AR expression levels were compared across gliomas of different histopathologic grades and molecular subtypes. Kaplan–Meier analyses in patients with different AR expression levels were investigated for the potential prognostic values of AR. Compared with normal brain tissue, gliomas show significantly higher AR mRNA expression ( …

Prevalence Of Cardiometabolic Risk Factors In Women: Insights From The Houston Heartreach Study, Arjun R Raghuram, Matthew W Segar, Stephanie Coulter, Joseph G Rogers

The Texas Heart Institute Journal

BACKGROUND: Cardiovascular disease is the leading cause of death among women in the United States. Past research has highlighted the importance of the relationship between female-specific demographics and traditional risk factors. The present analysis aimed to identify the prevalence of modifiable risk factors in women attending a community cardiovascular health screening.

METHODS: Data collected between 2011 and 2019 were obtained from the Houston HeartReach Registry. Participants were classified as having or not having each of 4 traditional cardiometabolic risk factors: hypertension, diabetes, body mass index indicating overweight or obesity, and dyslipidemia. Differences in prevalence were compared using the Pearson χ2 …

Noninvasive Multi-Cancer Detection Using Blood-Based Cell-Free Micrornas, Jason Zhang, Hallgeir Rui, Hai Hu

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Patients diagnosed with early-stage cancers have a substantially higher chance of survival than those with late-stage diseases. However, the option for early cancer screening is limited, with most cancer types lacking an effective screening tool. Here we report a miRNA-based blood test for multi-cancer early detection based on examination of serum microRNA microarray data from cancer patients and controls. First, a large multi-cancer training set that included 1,408 patients across 7 cancer types and 1,408 age- and gender-matched non-cancer controls was used to develop a 4-microRNA diagnostic model using 10-fold cross-validation. In three independent validation sets comprising a total of …

Use Of Web-Based Decision Support To Improve Informed Choice For Chemoprevention: A Qualitative Analysis Of Pre-Implementation Interviews (Swog S1904), Ana Sandoval-Leon

All Publications

Background: Women with high-risk breast lesions, such as atypical hyperplasia (AH) or lobular carcinoma in situ (LCIS), have a 4- to tenfold increased risk of breast cancer compared to women with non-proliferative breast disease. Despite high-quality data supporting chemoprevention, uptake remains low. Interventions are needed to break down barriers.

Methods: The parent trial, MiCHOICE, is a cluster randomized controlled trial evaluating the effectiveness and implementation of patient and provider decision support tools to improve informed choice about chemoprevention among women with AH or LCIS. For this pre-implementation analysis, 25 providers participated in semi-structured interviews prior to accessing decision support tools. …

Delusive Nature Of Flip-Flop Sign Secondary To Histoplasmosis, Omer Riyadh, Omron Hassan, Yashwanth Yerramalla

Student Publications

Histoplasmosis, caused by Histoplasma capsulatum, often mimics the appearance of lung cancer on fludeoxyglucose (FDG) positron emission tomography (PET) scans. The “flip-flop fungus,” due to its similar presentation on imaging modalities, can lead to false-positive results and unnecessary invasive testing. We present a 46-year-old male patient with a lung nodule and bilateral hilar lymphadenopathy on an FDG-PET scan who initially presented with chest discomfort. Histoplasma infection was confirmed through Grocott's methenamine silver (GMS) stains on bronchoscopy-guided biopsy specimens. An analysis of additional cases from the literature highlighted the diverse clinical presentations and outcomes associated with this condition that may be …

Consulting Ss, Inc. V. Gorham

All Decisions

AT2 consolidated three appeals by the same landlord, who sought to evict tenants from a basement apartment and two SRO units, claiming the building was a two-family dwelling and not rent-stabilized. Each tenant argued the building had seven residential units—one apartment and six SROs—making it subject to rent stabilization. The lower court agreed with the tenants, granting summary judgment due to the landlord's failure to serve required statutory termination notices. The Appellate Term affirmed, ruling that the building’s rent stabilization status depends on the units’ function as residences, regardless of their legality under a certificate of occupancy.

Expanded Gene And Taxon Sampling Of Diplomonads Shows Multiple Switches To Parasitic And Free-Living Lifestyle, Monika Wiśniewska, Erik Salomaki, Jeffrey D. Silberman, Kristina Terpis, Eva Mazancová, Petr Táborský, Vasana Jinathama, Eleni Gentekaki, Ivan Čepička, Martin Kolisko

Biological Sciences Faculty Publications and Presentations

Background

Diplomonads are anaerobic flagellates classified within Metamonada. They contain both host-associated commensals and parasites that reside in the intestinal tracts of animals, including humans (e.g., Giardia intestinalis), as well as free-living representatives that inhabit freshwater and marine anoxic sediments (e.g., Hexamita inflata). The evolutionary trajectories within this group are particularly unusual as the free-living taxa appear to be nested within a clade of host-associated species, suggesting a reversal from host-dependence to a secondarily free-living lifestyle. This is thought to be an exceedingly rare event as parasites often lose genes for metabolic pathways that are essential to a …

James K. Moyle Petitioner/ Appellant V. Brianna Moyle Respondent/ Appellee : Brief Of Appellee, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Appeal from the Fourth Judicial District Court, Wasatch County, Utah The Honorable Jennifer Mabey, Presiding

Bart J. Johnsen, Sarah Jenkins Dewey, Hannah Ector, Attorneys for Appellee Brianna Moyle

Jazz Ensembles I And Ii: September 27, 2024, Dr. Tom Marko

School of Music Programs

Center for the Performing Arts

September 27, 2024

Friday Evening

8:00 p.m.

Multimodal Functional Imaging And Clinical Correlates Of Pain Regions In Chronic Low-Back Pain Patients Treated With Spinal Cord Stimulation: A Pilot Study, Yazan Shamli Oghli, Arjun Ashok, Steven Glener, Isaiah Ailes, Mashaal Syed, Kichang Kang, Sara Naghizadeh Kashani, Islam Fayed, Feroze Mohamed, Kiran Talekar, Laura Krisa, Chengyuan Wu, Caio Matias, Mahdi Alizadeh

Department of Radiology Faculty Papers

OBJECTIVE: Spinal cord stimulation (SCS) is an invasive treatment option for patients suffering from chronic low-back pain (cLBP). It is an effective treatment that has been shown to reduce pain and increase the quality of life in patients. However, the activation of pain processing regions of cLBP patients receiving SCS has not been assessed using objective, quantitative functional imaging techniques. The purpose of the present study was to compare quantitative resting-state (rs)-fMRI and arterial spin labeling (ASL) measures between SCS patients and healthy controls and to correlate clinical measures with quantitative multimodal imaging indices in pain regions.

METHODS: Multi-delay 3D …

September 27, 2024 Minutes, Swosu Faculty Senate

Faculty Senate Minutes

No abstract provided.

No. 105 An Order To Provide Relief To Victims Of Severe Weather And Flooding In Tennessee, Bill Lee

Executive Orders

No abstract provided.

The Bg News September 27, 2024, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. September 27, 2024. Homecoming Issue.

James Moyle V. Brianna Moyle : Brief Of Appellee, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Appeal from the Fourth Judicial District Court, Wasatch County, Utah The Honorable Jennifer Mabey, Presiding

Bart J. Johnsen, USB 7068 Sarah Jenkins Dewey, USB 15640 Hannah Ector, USB 17980 PARSONS BEHLE & LATIMER Attorneys for Appellee Brianna Moyle