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Articles 29341 - 29370 of 5149626
Full-Text Articles in Entire DC Network
Environmental Mercury Alters Immune Pathways Linked To Autoimmune Risk In Mice Mirroring Humans, Maurgan Lee, Paul Stemmer, Randall Gill, Allen Rosenspire, Anil Aranha, Heather Gibson
Environmental Mercury Alters Immune Pathways Linked To Autoimmune Risk In Mice Mirroring Humans, Maurgan Lee, Paul Stemmer, Randall Gill, Allen Rosenspire, Anil Aranha, Heather Gibson
Medical Student Research Symposium
Background and Purpose: Mercury is a pervasive environmental contaminant, and human epidemiologic studies have linked chronic low-level exposure to increased autoimmune disease-risk. Dysregulated lymphocyte activation and impaired signaling tolerance are central mechanisms in human autoimmunity. Protein phosphorylation governs lymphocyte differentiation and function, alterations in phosphoproteomic networks may represent a signature of immune disruption. This study evaluates how low dose mercury exposure modifies B and T cell abundance and intracellular signaling patterns in BALB/c and Diversity Outbred (DO) mice.
Methods: BALB/c and DO mice were exposed to low dose HgCl2 in their water for two weeks or provided standard water controls. …
Age-Dependent Physiologic Differences And Predicted Survival In Pediatric Trauma Patients, Christian Hudson-Bradford Md, Laura Elizabeth Sansoterra, Elika Ridelman Phd, Samantha Carranza, Megan Zacarias, Christina Shanti Md
Age-Dependent Physiologic Differences And Predicted Survival In Pediatric Trauma Patients, Christian Hudson-Bradford Md, Laura Elizabeth Sansoterra, Elika Ridelman Phd, Samantha Carranza, Megan Zacarias, Christina Shanti Md
Medical Student Research Symposium
Background:
Pediatric trauma patients exhibit outcomes not fully captured by adult-derived prediction models. This study examined clinical measures associated with predicted survival in this population.
Methods:
A retrospective review was conducted at a level one pediatric trauma center for patients ≤12 years old admitted between July 2015 and October 2024 with major trauma (Injury Severity Score (ISS) >15). A total of 406 eligible cases were categorized by Trauma and Injury Severity Score (TRISS) survival probability as preventable (>0.50), possibly preventable (0.25–0.50), or non-preventable (< 0.25). Demographic, physiologic, and management variables were compared using Kruskal–Wallis and chi-square tests with Bonferroni correction.
Results:
Most patients were classified as preventable (83%), followed by possibly preventable (9.8%) and non-preventable …
Comparative Effectiveness Of Liposomal Bupivacaine And Regional Nerve Blocks For Analgesia After Total Knee Arthroplasty, Ahmed Makled, Amir Ghafarian, Jawad Saad, Muhammed Zahriyeh, Muaaz Wajahath, Khaled Saleh
Comparative Effectiveness Of Liposomal Bupivacaine And Regional Nerve Blocks For Analgesia After Total Knee Arthroplasty, Ahmed Makled, Amir Ghafarian, Jawad Saad, Muhammed Zahriyeh, Muaaz Wajahath, Khaled Saleh
Medical Student Research Symposium
Title: Comparative Effectiveness of Liposomal Bupivacaine and Regional Nerve Blocks for Analgesia After Total Knee Arthroplasty
Introduction: Liposomal bupivacaine (Exparel) has been adopted in total knee arthroplasty (TKA) as a long-acting local anesthetic. However, its comparative effectiveness against standard regional anesthesia techniques, such as femoral or adductor canal block, remains insufficiently defined. This study evaluates postoperative analgesic utilization following TKA among patients receiving Exparel, regional blocks, or no regional intervention, using matched cohorts from a large national dataset.
Methods: Patients who underwent primary TKA between January 1, 2005 and January 1, 2025 were retrospectively identified from a multi-institutional electronic medical …
Real-World Clinical Outcomes Of Robotic-Assisted Total Knee Arthroplasty: A Propensity-Matched Comparative Study, Hassan Yassine, Amir Ghafarian, Jawad Saad, Abdel Kareem Hilo, Muaaz Wajahath, Khaled Saleh
Real-World Clinical Outcomes Of Robotic-Assisted Total Knee Arthroplasty: A Propensity-Matched Comparative Study, Hassan Yassine, Amir Ghafarian, Jawad Saad, Abdel Kareem Hilo, Muaaz Wajahath, Khaled Saleh
Medical Student Research Symposium
Background:
Robotic-assisted total knee arthroplasty (RA-TKA) is increasingly utilized to improve component alignment and soft-tissue balance, yet its impact on clinically meaningful outcomes in large real-world populations remains uncertain. Although prior studies demonstrate improved radiographic accuracy, whether robotic assistance reduces postoperative complications, opioid utilization, or midterm mechanical failure has not been established at scale.
Methods:
We conducted a retrospective, propensity-matched cohort study using the TriNetX US Collaborative Network to identify adults undergoing primary TKA from 2018–2023. Robotic-assisted procedures were defined by CPT 27447 with concurrent robotic navigation codes. Propensity score matching (1:1) was performed to balance demographics and comorbidities, yielding …
Malnutrition At The Time Of Surgery Predicts Increased Morbidity After Distal Femur Fracture Fixation: A Propensity-Matched Analysis, Jawad Saad, Amir Ghafarian, Tyler Forbes, Muaaz Wajath, Noor Saad, Khaled Saleh
Malnutrition At The Time Of Surgery Predicts Increased Morbidity After Distal Femur Fracture Fixation: A Propensity-Matched Analysis, Jawad Saad, Amir Ghafarian, Tyler Forbes, Muaaz Wajath, Noor Saad, Khaled Saleh
Medical Student Research Symposium
Abstract
Background: Distal femur fractures (DFF) are serious injuries most often affecting older adults with multiple medical comorbidities. Malnutrition is known to worsen outcomes in elective orthopedic surgery, but its impact in urgent DFF fixation, where optimization time is limited, remains unclear. This study evaluated whether preoperative malnutrition predicts 90-day morbidity after DFF fixation and whether implant choice influences risk among malnourished patients.
Methods: Adults undergoing operative DFF fixation from 2005–2025 were identified using the TriNetX U.S. Collaborative Network. Malnutrition was defined as serum albumin ≤3.5 g/dL or leukocyte count ≤1.5×10³/µL within one year preoperatively. After 1:1 propensity matching for …
Maternal Cardiovascular Outcomes In Pregnancies Complicated By Pulmonary Hypertension: A Multicenter Cohort Study, Ali Eidy, Aiden Tang, Tarun Bomma, Prit Patel, Asa Smith-Villegas, Ali Awad Md
Maternal Cardiovascular Outcomes In Pregnancies Complicated By Pulmonary Hypertension: A Multicenter Cohort Study, Ali Eidy, Aiden Tang, Tarun Bomma, Prit Patel, Asa Smith-Villegas, Ali Awad Md
Medical Student Research Symposium
Title: Maternal Cardiovascular Outcomes in Pregnancies Complicated by Pulmonary Hypertension: A Multicenter Cohort Study
Authors: Ali Eidy, BS, Aiden Tang, BS, Tarun Bomma, BS, Prit Patel, BS, Asa Smith-Villegas, BS, Ali Awad, MD
Background: Routine pregnancies exhibit a considerable amount of cardiovascular strain, which is only amplified when complicated by pulmonary hypertension (PH). Despite advances in PH treatment and therapy, there is limited data that shows the outcomes of PH on maternal cardiovascular health. This study evaluated these risks across a large, diverse cohort to better understand how PH affects maternal hemodynamics and cardiac functions.
Methods: Using the TriNetX Research …
Five-Year Prescription Trends In Anti-Vegf Utilization: A Randomized Sampling Of Real-World Injection Patterns, Sarah Noonan Bs, Batoul Dabajeh Bs, Richard Tuttle Bs, Ahmad Yousef Ba, Mba, Paul Edwards Md, Katherine Jaje Md, Deedra Lapointe Mha, Robert Culmone Cpa, Charles S. Day Md, Mba
Five-Year Prescription Trends In Anti-Vegf Utilization: A Randomized Sampling Of Real-World Injection Patterns, Sarah Noonan Bs, Batoul Dabajeh Bs, Richard Tuttle Bs, Ahmad Yousef Ba, Mba, Paul Edwards Md, Katherine Jaje Md, Deedra Lapointe Mha, Robert Culmone Cpa, Charles S. Day Md, Mba
Medical Student Research Symposium
Background
Previous studies have demonstrated that bevacizumab (Avastin) achieves comparable visual outcomes to branded agents such as aflibercept (Eylea), ranibizumab (Lucentis), and faricimab (Vabysmo), while offering a substantially lower cost. This study evaluates five-year prescription trends across three cohorts to identify changing utilization patterns. Real-world prescription behaviors enable this analysis to provide insight into clinical decision-making and to highlight opportunities to enhance value-based ophthalmic care.
Methods
A retrospective, descriptive analysis was conducted using electronic medical record data between 2020-2025. Three patient cohorts were identified based on anti-VEGF injection type and sequence:
-
Cohort 1: Bevacizumab (Avastin) only
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Cohort 2: Bevacizumab (Avastin) …
Variation In Baroreceptor Sensitivity Prevents Generalized Anxiety, Alexander Weaver, Jack Summers, Judy Taha, Zachary Miklja, Warren Lockette
Variation In Baroreceptor Sensitivity Prevents Generalized Anxiety, Alexander Weaver, Jack Summers, Judy Taha, Zachary Miklja, Warren Lockette
Medical Student Research Symposium
VARIATION IN BARORECEPTOR SENSITIVITY PREVENTS GENERALIZED ANXIETY. Alexander Weaver, Jack Summers, Judy Taha, Zak Miklja, Warren Lockette. Division of Endocrinology, Wayne State University School of Medicine, Detroit, MI.
Key words: anxiety, baroreceptors, cardiovascular disease, PIEZO 1, humans, instantaneous baroreceptor sensitivity
BACKGROUND
We reported ex vivo measurements of PIEZO 1 channel activity in erythrocytes can predict those individuals with high levels of generalized anxiety. Because PIEZO 1 channels are expressed in cardiac baroreceptors, we next tested our hypothesis that contrasts in generalized anxiety in the population could be due to individual differences in PIEZO 1-dependent instantaneous baroreceptor sensitivity.
METHODS
Thirteen …
Economic Perspectives On Medical Training: A Specialty-Level Break-Even Analysis For Wayne Trained Physicians, Michael Niculcea, Joseph Kunnappilly, Isaak Miller, Connor Genschaw, Biola Makinde-Odusola
Economic Perspectives On Medical Training: A Specialty-Level Break-Even Analysis For Wayne Trained Physicians, Michael Niculcea, Joseph Kunnappilly, Isaak Miller, Connor Genschaw, Biola Makinde-Odusola
Medical Student Research Symposium
Title:
Economic Perspectives on Medical Training: A Specialty-Level Break-Even Analysis for Wayne Trained Physicians
Michael Niculcea, Joseph Kunnappilly, Isaak Miller, Connor Genschaw, Biola Makinde-Odusola
Background:
U.S. medical students graduate with high educational debt, yet financial literacy remains overlooked in medical school curricula. Trainees enter residency with a limited understanding of how specialty and loan repayment strategies affect long-term finances. Break-even analysis, which identifies when total revenue exactly offsets total costs, can help students at Wayne State University School of Medicine (WSUSOM) better visualize the factors shaping their financial futures.
Methods:
This analysis assumes 4 years of medical school financed entirely …
Impact Of Dietician Counseling On Outcomes In Newly Diagnosed Celiac Disease, Andreas Mozny B.A., Alyusuf Elnaggar B.A., James Mo M.D., Suraj Suresh M.D.
Impact Of Dietician Counseling On Outcomes In Newly Diagnosed Celiac Disease, Andreas Mozny B.A., Alyusuf Elnaggar B.A., James Mo M.D., Suraj Suresh M.D.
Medical Student Research Symposium
Title: Impact of Dietician Counseling on Outcomes in Newly Diagnosed Celiac Disease
Background: Dietician counseling is routinely recommended for newly diagnosed celiac disease (CD), yet its measurable impact is not well defined. This study examined whether early dietician involvement improves clinical symptoms or serologic outcomes.
Methods: We retrospectively reviewed adults with biopsy-confirmed CD at a single center from 2020–2024. Demographics, symptoms, and laboratory data were collected by chart review with ≥6 months of follow-up. Patients who met with a dietician formed the dietician group; all others were assigned to the non-dietician group. Fisher's Exact tests evaluated abdominal …
Promising Efficacy Of Avapritinib In Pdgfra Ecdna–Amplified Glioblastoma, Sydni Rosenfeld, Artem Berezovsky, Indrani Datta, Andrea Transou, Susan Irtenkauf, Laura Hasselbach, Ana C. Decarvalho
Promising Efficacy Of Avapritinib In Pdgfra Ecdna–Amplified Glioblastoma, Sydni Rosenfeld, Artem Berezovsky, Indrani Datta, Andrea Transou, Susan Irtenkauf, Laura Hasselbach, Ana C. Decarvalho
Medical Student Research Symposium
Background: Avapritinib, a selective inhibitor of mutated class III receptor tyrosine kinases (RTKs), shows promise in PDGFRA-altered pediatric glioma. We studied its efficacy in a glioblastoma (GBM) model (HF3253) containing two PDGFRA alterations: constitutive activation via an indel mutation and extrachromosomal DNA (ecDNA) amplification. We hypothesized that Avapritinib would preferentially improve survival in PDGFRA-amplified tumors.
Methods: Orthotopic xenografts derived from HF3253 PDGFRA ecDNA(+) (n=19) and ecDNA(-) (n=10) cells were treated with 40 mg/kg Avapritinib (5 days/week). To validate the role of PDGFRA expression, wild-type PDGFRA was overexpressed in ecDNA(-) cells, generating high PDGFRA levels with minimal ligand-independent activation in vivo. …
Speed And Cosmetic Outcomes Of Skin Closure Methods In Head And Neck Surgery: A Network Meta-Analysis Of Randomized Trials, Marcel Addis Jackson, Jacob Nielsen, John Cramer
Speed And Cosmetic Outcomes Of Skin Closure Methods In Head And Neck Surgery: A Network Meta-Analysis Of Randomized Trials, Marcel Addis Jackson, Jacob Nielsen, John Cramer
Medical Student Research Symposium
Background The optimal skin-closure technique in head and neck surgery is uncertain, with sutures, staples, and tissue adhesive (glue) all in common use.
Objective To compare time to skin closure, postoperative scar appearance, overall surgical time, and cost across sutures, staples, and glue in head and neck surgery.
Methods We systematically screened 549 records in Covidence and included prospective randomized controlled trials comparing sutures vs staples, staples vs glue, or glue vs sutures. Eight trials met eligibility; six were pooled and two summarized narratively. A random-effects network meta-analysis (MetaInsight) evaluated two primary outcomes: time to skin closure and scar score …
Enhanced Control Of Central Sleep Apnea With Adjunctive Therapy: Cpap Plus Oxygen And/Or Acetazolamide., Ali J. Mustapha, Maria Fatima, S. Shanker, A. Aldiwaikat, M. Habra, K. Jackson, S. Habra, M. Bawa, A. Moustapha, N. Pandya, S. Gosh, A. Sankari, M.S. Badr
Enhanced Control Of Central Sleep Apnea With Adjunctive Therapy: Cpap Plus Oxygen And/Or Acetazolamide., Ali J. Mustapha, Maria Fatima, S. Shanker, A. Aldiwaikat, M. Habra, K. Jackson, S. Habra, M. Bawa, A. Moustapha, N. Pandya, S. Gosh, A. Sankari, M.S. Badr
Medical Student Research Symposium
Background: Effective Treatment of central sleep apnea (CSA) remains elusive. CPAP may be an efficacious treatment for CSA, but it rarely eliminates CSA. The purpose of this investigation was to determine the efficacy of adding acetazolamide, low-flow oxygen, or both to CPAP therapy for CSA treatment.
Methods: A controlled, double-blinded, crossover study evaluated the efficacy of acetazolamide, supplemental oxygen, and their combination in reducing sleep-disordered breathing compared with standard PAP therapy. All 82 participants completed full polysomnography under five conditions: (1) Baseline, (2) Baseline PAP, (3) Acetazolamide at 250 mg at bedtime, (4) low-flow Oxygen ( 2-4 L/min), and (5) …
Assessing The Reproductive Potential Of Late Mature Cryopreserved Oocytes, Keri Bergin, Ashna Mehra
Assessing The Reproductive Potential Of Late Mature Cryopreserved Oocytes, Keri Bergin, Ashna Mehra
Medical Student Research Symposium
Title: Assessing the reproductive potential of late mature cryopreserved oocytes
Authors: Keri Bergin, Ashna Mehra, Rick Slifkin, Morgan Baird, Dmitry Gounko, Carlos Hernandez-Nieto, Joseph Lee, Chelsea Canon, Alan B Copperman, Lucky Sekhon
Background:
Oocytes retrieved at the germinal vesicle (GV) or metaphase I (MI) stage may mature in vitro to MIIs for cryopreservation. Limited data exist on the reproductive potential of late mature MIIs after thaw. This study assesses the thaw, fertilization, and embryo development outcomes of late mature versus immediately mature cryopreserved oocytes.
Methods:
This retrospective cohort study analyzed autologous oocyte cryopreservation cycles with thaws from January 2016 – …
Oct Evidence Supports Oxidative Stress And Retinoid Deficiency But Not Mitochondrial Inefficiency During Healthy Human Aging, Laura Zvinys, Ehimenmen Ataman, Sukhanjit Kaur, Saleh Ahmed, Madelyn Moretti, Megan Johnson, James Soetedjo, Harman Bindra, Emmaline O'Neil, Rida Waseem, Yannick Liermann, Sarah Thiele, Bruce Berkowitz Phd
Oct Evidence Supports Oxidative Stress And Retinoid Deficiency But Not Mitochondrial Inefficiency During Healthy Human Aging, Laura Zvinys, Ehimenmen Ataman, Sukhanjit Kaur, Saleh Ahmed, Madelyn Moretti, Megan Johnson, James Soetedjo, Harman Bindra, Emmaline O'Neil, Rida Waseem, Yannick Liermann, Sarah Thiele, Bruce Berkowitz Phd
Medical Student Research Symposium
Background: To test for evidence of macula oxidative stress, impaired retinoid handling, and/or photoreceptor energy inefficiencies during healthy human aging as measured by next-generation OCT biomarkers.
Methods: OCT was used to examine light-adapted 20-30 and 70-90-year-old, male and female subjects without overt ophthalmologic disease. Two biomarkers were measured: 1) external limiting membrane (ELM) to retinal pigment epithelium (RPE) contraction, which can arise from oxidative stress-induced acidosis and is concordant with impaired spatial distribution of 11-cis retinal chaperone retinal binding protein 3, and 2) the sub-ELM hyperreflective band profile shape, or Mitochondria Configuration within Photoreceptor inner segments measured with …
Twice As Long, Half The Risk: Piccs Outperform Cvcs In Pediatric Burn Patients, Christian Hudson-Bradford Md, Megan Zacarias Bs, Samantha Carranza Bs, Elika Ridelman Phd, Christina Shanti Md
Twice As Long, Half The Risk: Piccs Outperform Cvcs In Pediatric Burn Patients, Christian Hudson-Bradford Md, Megan Zacarias Bs, Samantha Carranza Bs, Elika Ridelman Phd, Christina Shanti Md
Medical Student Research Symposium
Title: Twice as Long, Half the Risk: PICCs Outperform CVCs in Burn Patient
Christian Hudson-Bradford MD, Megan Zacarias BS, Elika Ridelman PhD, Samantha Carranza BS, Christina Shanti MD
Background: Venous access is critical in burn care for fluid resuscitation, medication delivery, and nutritional support. While central venous catheters (CVCs) are traditionally used, peripherally inserted central catheters (PICCs) offer an alternative option with a potentially favorable safety profile, longer dwell time, and reduced need for re-insertion. This study compares patient characteristics, complication rates, and catheter duration between PICC and CVC lines in pediatric burn patients, advocating for early PICC …
Comparison Of Non-Invasive Methods For Measuring Intracranial Hypertension, Danielle Santoyo, B.S., Eric Mylfurry, B.S., Marilyn Li, B.S., Matthew Mellor, B.S., Mercylia Untono, B.S., Urva Mehveen, B.S., Hari Ramakrishnan, B.S., James Paxton, M.D., M.B.A.
Comparison Of Non-Invasive Methods For Measuring Intracranial Hypertension, Danielle Santoyo, B.S., Eric Mylfurry, B.S., Marilyn Li, B.S., Matthew Mellor, B.S., Mercylia Untono, B.S., Urva Mehveen, B.S., Hari Ramakrishnan, B.S., James Paxton, M.D., M.B.A.
Medical Student Research Symposium
Introduction and Purpose of Review:
Intracranial hypertension (IHTN) is a serious complication associated with neurological injuries. Once IHTN is detected, it is crucial to make swift decisions regarding medical treatments. This review focuses on the effectiveness and utility of noninvasive methods used to detect IHTN in the emergency department (ED).
Methods:
We conducted a comprehensive search for PubMed articles to find data on non-invasive intracranial pressure (ICP) evaluation methods including; optic nerve sheath diameter ultrasound (ONSS), automated infrared pupillometry (AIP), Tympanic Membrane Displacement (TMD), Transcranial Doppler Ultrasound (TDU), CT, and MRI. We compared; cost, accuracy, estimated time per method, specificity …
Federated Cognitive Twins, Johny Manuel-Devadoss, Joanna Johnson, Jayden Johnson
Federated Cognitive Twins, Johny Manuel-Devadoss, Joanna Johnson, Jayden Johnson
Defensive Publications Series
The current generation of personalization systems is fundamentally constrained by a centralized representational paradigm in which users are reduced to static behavioral embeddings owned and monetized by platform operators. Existing recommender architectures infer preference vectors from fragmented interaction telemetry and optimize engagement through increasingly opaque reinforcement pipelines. Such systems exhibit severe deficiencies in epistemic continuity, user sovereignty, contextual cognition, longitudinal identity fidelity, and privacy-preserving personalization. This paper introduces Federated Cognitive Twins (FCT), a next-generation computational architecture for continuously evolving, cryptographically sovereign, locally anchored cognitive simulations representing human behavioral dynamics, ethical priors, attentional signatures, learning topology, persuasion resistance characteristics, trust propagation …
Multi-Agent Collaboration, Wenhan Gao, Xiran Fan, Michael Yeh, Jiarui Sun, Yuzhong Chen, Menghai Pan
Multi-Agent Collaboration, Wenhan Gao, Xiran Fan, Michael Yeh, Jiarui Sun, Yuzhong Chen, Menghai Pan
Defensive Publications Series
Present disclosure provides systems, methods, and computer program products for multi-agent collaboration. A system includes at least one processor configured to generate, with a first software agent, an account holder profile based on transaction data for previous payment transactions, generate, with a second software agent, a plurality of merchant profiles for a plurality of merchants based on the stored transaction data and on external data, receive a query comprising a merchant name and context data, in response to the query, determine a matching merchant profile from the plurality of merchant profiles based on the merchant name and the context data, …
Solid-State Forms Of Camizestrant, Prashanth Venukathala, Venukathala Prashanth
Solid-State Forms Of Camizestrant, Prashanth Venukathala, Venukathala Prashanth
Defensive Publications Series
The present invention relates to solid-state forms of camizestrant, including crystalline polymorphs, amorphous forms, co-crystals, solvates, hydrates, and amorphous solid dispersions. The invention further provides processes for their preparation and pharmaceutical compositions comprising these forms. These solid forms exhibit improved physicochemical properties such as solubility, stability, and bioavailability, making them suitable for therapeutic applications.
Technical Disclosure: Arachne Core Polymer Interposer (Rev-2026), Michael Victor Caldwell Mr.
Technical Disclosure: Arachne Core Polymer Interposer (Rev-2026), Michael Victor Caldwell Mr.
Defensive Publications Series
This disclosure presents a high-thermal-conductivity polymer interposer for chiplet-based electronic packaging, utilizing a pre-aligned Dyneema SK78 ultra-high molecular weight polyethylene (UHMWPE) film within a modified low-temperature-curing cyanate ester resin matrix. To overcome the thermal processing limitations of conventional UHMWPE, this design employs a 15% volume fraction of sub-micron boron nitride (BN) dopants and a specialized ultraviolet (UV) radical cross-linking protocol, enabling fabrication at a maximum temperature of $105^\circ\text{C}–110^\circ\text{C}$. This avoids the structural relaxation and melting threshold of the UHMWPE fibers. The resulting composite achieves an effective in-plane thermal conductivity ($K_{eff}$) of $22.4\text{ W/mK}$ and a cross-plane conductivity of $2.1\text{ W/mK}$, …
Generative Audio Replacement Via Temporal And Spectral Matching, Tamar Yakar, Ilia Labzovsky
Generative Audio Replacement Via Temporal And Spectral Matching, Tamar Yakar, Ilia Labzovsky
Defensive Publications Series
A system related to generative audio replacement via temporal and spectral matching. The system extracts a Semantic Audio Profile from a reference audio track including temporal features and spectral/tonal features, generates replacement audio using a generative model conditioned on the profile with temporal control signals for beat alignment, performs source separation to preserve dialogue and sound effects, and mixes the generated audio with preserved stems to produce synchronized replacement audio.
Type Iv Black Hole Observatory — Structural Analysis Of 2 Enoch As A Candidate Witness Architecture, Daniel Austin Harbison
Type Iv Black Hole Observatory — Structural Analysis Of 2 Enoch As A Candidate Witness Architecture, Daniel Austin Harbison
Defensive Publications Series
This disclosure documents a structural correspondence between the ten-heaven cosmology
described in 2 Enoch (the Slavonic apocalypse, long recension) and the architecture that would
be produced by a deeply nested observatory or habitat system around a supermassive black
hole. The claim is structural, not physical. The text is not asserted to encode measured
astrophysics. It is asserted that the specific pattern of features in the text — exhaustive counts
of beings and objects, durations of cycles, structural relations and ordering, combined with the
conspicuous absence of absolute distances or sizes — is the data pattern that would be
produced by …
Spectral Retriever For Large Language Model (Llm) Multi Agent Systems, Andrea Morandi, Saurabh Gupta
Spectral Retriever For Large Language Model (Llm) Multi Agent Systems, Andrea Morandi, Saurabh Gupta
Defensive Publications Series
When artificial intelligence (AI) agents search large product catalogs, conventional retrieval systems often return the wrong document because they compress each document into a single summary vector, losing small but critical details that distinguish one product from another. Proposed herein is a spectral retriever technique that addresses this problem by examining documents at multiple levels of detail at the same time, from individual product identifiers to overall document meaning. The spectral retriever technique automatically determines whether a query calls for fine-grained matching, broader semantic understanding, or an intermediate level of granularity, without domain-specific rules or model retraining.
Agentic Experience And Routing Optimization Using Web Model Context Protocol, Linda St. Marie, Anjani Kumar Thakur
Agentic Experience And Routing Optimization Using Web Model Context Protocol, Linda St. Marie, Anjani Kumar Thakur
Defensive Publications Series
A system and method are described for preserving and executing multi-variable user intent between an advertisement medium and a destination digital platform. The technology utilizes web model context protocols to allow a destination platform to declare available functions via code microdata. Upon user interaction with an advertisement, a context provider constructs an encoded payload representing the intent, which is transmitted to the action provider. A client-side orchestrator decodes and executes the intended actions to alter the destination state dynamically without relying on static backend routing. Keywords: Context provider, action provider, intent routing, web model context protocol, client-side execution, digital advertising.
Hydrosynbio H₂O-Matrix System: Integrated Bio-Photonic Water Synthesis Platform With Hybrid Apccm+Depb Gas Separation And Ai-Neural Optimization, Mohammed Hani Jebreen
Hydrosynbio H₂O-Matrix System: Integrated Bio-Photonic Water Synthesis Platform With Hybrid Apccm+Depb Gas Separation And Ai-Neural Optimization, Mohammed Hani Jebreen
Defensive Publications Series
The HydroSynBio™ H₂O-Matrix System is a novel integrated bio-photonic platform for atmospheric water synthesis. The system combines dual-chamber photobioreactors using Chlamydomonas reinhardtii for biological hydrogen production and Elodea canadensis for oxygen production, powered by solar energy.
The core inventive step is a hybrid low-energy gas separation technology (APCCM asymmetric polymer-ceramic membrane + DEPB dynamic electrochemical potential barrier) coupled with pulsed pressure-swing adsorption, enabling efficient separation of biologically generated H₂ and O₂. The separated gases are then catalytically recombined in a Pt/C PEM reverse fuel cell to produce pure water.
The entire process is optimized in real-time by an AI-neural controller …
The Level Of Inclusion Of Motivational Enhancement Methods In The “Lughati Al- Khalidah” Textbooks At The Intermediate Stage In Light Of Expectancy–Value Theory From The Perspective Of Arabic Language Teachers, Dr. Yahya Ali Ageel Qenaey
The Level Of Inclusion Of Motivational Enhancement Methods In The “Lughati Al- Khalidah” Textbooks At The Intermediate Stage In Light Of Expectancy–Value Theory From The Perspective Of Arabic Language Teachers, Dr. Yahya Ali Ageel Qenaey
University of Bisha Journal for Educational Sciences
The present study aimed to examine the level of inclusion of motivational enhancement methods in the intermediate- stage textbook series “Lughati Al-Khalidah” in light of Expectancy–Value Theory from the perspectives of Arabic language teachers. A descriptive survey design was employed, and a questionnaire was administered to a sample of 93 teachers from the General Directorate of Education in the Asir region. The findings indicated a high overall level of inclusion of motivational enhancement methods in the textbooks, while the sub-items ranged between moderate and high. The obstacles to implementing these strategies were rated high overall, with sub-items also ranging between …
The Degree To Which Female Science Teachers In Riyadh Possess 21st-Century Skills, Haya Bint Mohammed Bin Abdullah Al-Subaie
The Degree To Which Female Science Teachers In Riyadh Possess 21st-Century Skills, Haya Bint Mohammed Bin Abdullah Al-Subaie
University of Bisha Journal for Educational Sciences
This study aimed to identify the degree to which female science teachers in Riyadh possess 21st-century skills. A descriptive survey methodology was utilized. A random sample of 278 science female teachers from middle public schools for the year 1446 AH was selected. To achieve the research objectives, a questionnaire comprising 50 items was developed, covering three primary dimensions: Learning and Creativity, Digital Literacy, and Life and Career Skills. The validity and reliability of the instrument were verified using appropriate statistical methods. The results showed that the degree of female science teachers’ possession of 21st-Century Skill was high, with a relative …
Faculty Members’ Perceptions Towards Employing Open Resource Educational Courses And The Obstacles To Its Uses In The Educational Process At Al-Baha University, Dr. Khaled Alshehri
Faculty Members’ Perceptions Towards Employing Open Resource Educational Courses And The Obstacles To Its Uses In The Educational Process At Al-Baha University, Dr. Khaled Alshehri
University of Bisha Journal for Educational Sciences
The study aimed to explore the perceptions of faculty members at Al-Baha University regarding the employment of open resource educational courses and the obstacles to its uses in the educational process. The descriptive comparative method was employed, and a questionnaire was administered to a sample of (213) faculty members from various academic disciplines. The findings revealed that faculty members’ perceptions toward the use of open resource educational courses were high across cognitive, affective, and behavioral dimensions, reflecting a positive awareness of their role in enhancing educational quality and improving self-learning skills. The results also indicated that the level of obstacles …
The Analytic Hierarchy Process As A Tool For Architectural Quality Assessment: A Case Study On Municipal Facades, Gül Şebnem Tutal, Fatma Demet Aykal
The Analytic Hierarchy Process As A Tool For Architectural Quality Assessment: A Case Study On Municipal Facades, Gül Şebnem Tutal, Fatma Demet Aykal
HBRC Journal
This study evaluates the façade quality of three municipal buildings using the Analytic Hierarchy Process (AHP) to identify strengths, weaknesses, and improvement priorities in public architecture. Although façade design has been widely studied, quantitative and integrated assessment frameworks for municipal building façades remain limited. To address this gap, the study integrates the Design Quality Indicator (DQI) with AHP within a Multi-Criteria Decision Making (MCDM) framework, proposing a systematic and replicable evaluation model. The research assesses three main DQI criteria-functionality, building quality, and impact-subdivided into twelve sub-criteria and analyzed through pairwise comparison matrices. Data were collected through structured expert interviews with …