Digital Commons Network^™

Eastern Baccharis Control In Newly Planted Wetland Reserve Programs, Lucas Stamper

LSU Doctoral Dissertations

The Lower Mississippi Alluvial Valley is a high-priority region for restoration of bottomland hardwood forests. Restoration of these forests is facilitated through conservation easement programs, such as the Conservation Reserve Program (CRP) and the Wetland Reserve Program (WRP), which focus on retiring marginal agriculture land and restoring bottomland hardwoods. A prominent issue that reduces hardwood establishment success is the failure to suppress competing vegetation, like eastern baccharis (Baccharis halimifolia L.), that aggressively colonize a site after seedlings are planted. Eastern baccharis is a frequent woody invader of disturbed bottomland sites throughout northeast Louisiana. There are few chemical options for …

Learning Problems Related To Stochastic Differential Equations, Jinpu Zhou

LSU Doctoral Dissertations

Stochastic differential equations (SDEs) are essential for modeling systems influenced by both deterministic dynamics and random fluctuations, with applications in a wide variety of disciplines. This thesis develops a Bayesian framework for nonparametric learning in SDEs, addressing key challenges in inference, particularly when dealing with complex systems and incomplete data. The thesis begins by establishing a theoretical foundation in optimization over Hilbert spaces, including a generalized representer theorem to address infinite-dimensional optimization problems encountered in nonparametric inference. Building on this, we introduce a Bayesian framework with shrinkage priors to learn drift functions from high-frequency data. Bayesian approach incorporates low-cost sparse …

Precision Bottlebrush Polymers: Synthesis, Characterization, And Structure-Property Relationship, Nduka D. Ogbonna

LSU Doctoral Dissertations

Bottlebrush polymers, a type of non-linear polymer characterized by densely grafted side chains on a linear backbone, offer a versatile platform for material design due to their unique thermomechanical and rheological behavior. Addressing the grand challenge of achieving structural precision for bottlebrush polymers remains crucial because traditional disperse mixtures are plagued with batch variability, limiting our ability to control their functions, and correlate theoretical predictions with experiments. To date, narrow-dispersity bottlebrush polymers remain highly heterogeneous, as they are typically synthesized from disperse linear building blocks.

To address this longstanding challenge of structural heterogeneity in brush polymers, the primary objective of …

Redefining The Art Songs Of Maude Valérie White, Sarah C. Rees

LSU Doctoral Dissertations

Maude Valérie White (1866-1937) was an English composer during the Victorian Era. Her main output was in the genre of art song, of which she wrote more than two hundred during her life. Her music was very popular at the height of her career around 1880-1890, but fell out of favor with the general public in line with the general reaction against Victorian art and ideals. This written document focuses on the life of Maude Valérie White contextualized within the ideals of Victorian womanhood. It will explore the development of her musical style through eight song analyses: The Devout Lover, …

Clinical Trials For Lennox-Gastaut Syndrome: Challenges And Priorities, Juliet K Knowles, Aaron E L Warren, Ismail S Mohamed, Carl E Stafstrom, Hyun Yong Koh, Debopam Samanta, Renée A Shellhaas, Gita Gupta, Tracy Dixon-Salazar, Linh Tran, Sonal Bhatia, Jane M Mccabe, Anup D Patel, Zachary M Grinspan

2020-Current year OA Pubs

OBJECTIVE: Lennox-Gastaut syndrome (LGS) is a severe, childhood-onset epilepsy that is typically refractory to treatment. We surveyed the current landscape of LGS treatment, aiming to identify challenges to the development of efficacious therapies, and to articulate corresponding priorities toward clinical trials that improve outcomes.

METHODS: The LGS Special Interest Group of the Pediatric Epilepsy Research Consortium integrated evidence from the literature and expert opinion, into a narrative review.

RESULTS: We provide an overview of approved and emerging medical, dietary, surgical and neuromodulation approaches for LGS. We note that quality of care could be improved by standardizing LGS treatment based on …

Efficacy, Safety, And Quality Of Life 4 Years After Valoctocogene Roxaparvovec Gene Transfer For Severe Hemophilia A In The Phase 3 Gener8-1 Trial, Andrew D Leavitt, Elaine Majerus, Et Al.

2020-Current year OA Pubs

BACKGROUND: Valoctocogene roxaparvovec, an adeno-associated virus-mediated gene therapy for severe hemophilia A, enables endogenous factor (F)VIII expression and provides bleed protection.

OBJECTIVES: Determine valoctocogene roxaparvovec durability, efficacy, and safety 4 years after treatment.

METHODS: In the phase 3 GENEr8-1 trial, 134 adult male persons with severe hemophilia A without inhibitors and previously using FVIII prophylaxis received a 6 × 10

RESULTS: Median follow-up was 214.3 weeks; 2 participants discontinued since the previous data cutoff. Declines from baseline in mean treated annualized bleed rate (-82.6%;

CONCLUSION: Valoctocogene roxaparvovec provides persistent FVIII expression, hemostatic control, and health-related quality of life improvements with …

A Finite Element Model For Biomechanical Characterization Of Ex Vivo Peripheral Nerve Dysfunction During Stretch, Nicholas C Vasas, Adam M Forrest, Nathaniel A Meyers, Michael B Christensen, Jenny L Pierce, Sidney M Kaufmann, Kimberly B Lanaghen, Randal C Paniello, Julie M Barkmeier-Kraemer, Jonathan P Vande Geest

2020-Current year OA Pubs

Peripheral nerve damage can cause debilitating symptoms ranging from numbness and pain to sensory loss and atrophy. To uncover the underlying mechanisms of peripheral nerve injury, our research aims to develop a relationship between biomechanical peripheral nerve damage and function through finite element modeling. A noncontact, ex vivo electrophysiology chamber, capable of axially stretching explanted nerves while recording electrical signals, was used to investigate peripheral nerve injury. Successive stretch trials were run on eight sciatic nerves (four females and four males) excised from Sprague-Dawley rats. Nerves were stretched until 50% compound action potential (CAP) amplitude reduction was obtained. A constitutive …

Fusobacterium Nucleatum Abundance Is Associated With Cachexia In Colorectal Cancer Patients: The Colocare Study, Mmadili N Ilozumba, Adetunji T Toriola, Et Al.

2020-Current year OA Pubs

BACKGROUND: Cachexia accounts for about 20% of all cancer-related deaths and indicates poor prognosis. The impact of Fusobacterium nucleatum (Fn), a microbial risk factor for colorectal cancer (CRC), on the development of cachexia in CRC has not been established.

METHODS: We evaluated the association between Fn abundance in pre-surgical stool samples and onset of cachexia at 6 months post-surgery in n = 87 patients with stages I-III CRC in the ColoCare Study.

RESULTS: High fecal Fn abundance compared to negative/low fecal Fn abundance was associated with 4-fold increased risk of cachexia onset at 6 months post-surgery (OR = 4.82, 95% …

Evaluation Of Combat Harmonization For Reducing Across-Tracer Differences In Regional Amyloid Pet Analyses, Braden Yang, Tom Earnest, Sayantan Kumar, Deydeep Kothapalli, Tammie Benzinger, Brian Gordon, Aristeidis Sotiras

2020-Current year OA Pubs

Differences in amyloid positron emission tomography (PET) radiotracer pharmacokinetics and binding properties lead to discrepancies in amyloid-β uptake estimates. Harmonization of tracer-specific biases is crucial for optimal performance of downstream tasks. Here, we investigated the efficacy of ComBat, a data-driven harmonization model, for reducing tracer-specific biases in regional amyloid PET measurements from [

Can Acetabular Dysplasia Be Measured On Axial Ct? A Measurement For Trauma Surgeons, Ravi R Agrawal, Eric R Barnard, Helena F Barber, Anna N Miller

2020-Current year OA Pubs

BACKGROUND: Acetabular dysplasia has been theorized as a risk factor instability amongst common acetabular fractures, such as posterior wall (PW) fractures. However, common radiographic measurements often cannot be acquired in trauma patients. We evaluated axial computed tomography (CT) scans to identify novel, easily-obtained measurements that correlate with acetabular dysplasia for use in surgical indications and planning.

METHODS: Patients with known acetabular dysplasia undergoing elective periacetabular osteotomy were selected. A different group of patients without pelvic ring or acetabular fractures from an institutional trauma registry were selected as a comparison group. Standard indices of dysplasia were collected, such as center-edge angle …

Reframing Burnout: Measuring “Altruistic Execution” To Understand Nurse Burnout, Jacqueline Christianson, Abir K. Bekhet, Jill L. Guttormson, Maharaj Singh, Norah L. Johnson

College of Nursing Faculty Research and Publications

Background:

Many nurses join the profession because they have altruistic intentions, but some nurses experience barriers to acting on altruistic intentions which may be a source of job dissatisfaction or burnout.

Objective:

The purpose of this study was to evaluate construct validity, internal consistency, and convergence reliability of the Nursing Altruistic Execution Scale (NAES), a novel instrument assessing the perceived ability to help others through work.

Methods:

The NAES was developed based upon a literature review examining altruistic behavior as a motivator for nursing work, with expert feedback for instrument refinement. Participants completed the NAES, Copenhagen Burnout Inventory Work-Related Burnout …

Psychiatric Neuroimaging Designs For Individualised, Cohort, And Population Studies, Martin Gell, Stephanie Noble, Timothy O Laumann, Steven M Nelson, Brenden Tervo-Clemmens

2020-Current year OA Pubs

Psychiatric neuroimaging faces challenges to rigour and reproducibility that prompt reconsideration of the relative strengths and limitations of study designs. Owing to high resource demands and varying inferential goals, current designs differentially emphasise sample size, measurement breadth, and longitudinal assessments. In this overview and perspective, we provide a guide to the current landscape of psychiatric neuroimaging study designs with respect to this balance of scientific goals and resource constraints. Through a heuristic data cube contrasting key design features, we discuss a resulting trade-off among small sample, precision longitudinal studies (e.g., individualised studies and cohorts) and large sample, minimally longitudinal, population …

Differential Chromatin Accessibility And Transcriptional Dynamics Define Breast Cancer Subtypes And Their Lineages, Michael D Iglesia, Reyka G Jayasinghe, Siqi Chen, Nadezhda V Terekhanova, John M Herndon, Erik Storrs, Alla Karpova, Daniel Cui Zhou, Nataly Naser Al Deen, Andrew T Shinkle, Rita Jui-Hsien Lu, Wagma Caravan, Andrew Houston, Yanyan Zhao, Kazuhito Sato, Preet Lal, Cherease Street, Fernanda Martins Rodrigues, Austin N Southard-Smith, André Luiz N Targino Da Costa, Houxiang Zhu, Chia-Kuei Mo, Lisa Crowson, Robert S Fulton, Matthew A Wyczalkowski, Catrina C Fronick, Lucinda A Fulton, Hua Sun, Sherri R Davies, Elizabeth L Appelbaum, Sara E Chasnoff, Madelyn Carmody, Candace Brooks, Ruiyang Liu, Michael C Wendl, Clara Oh, Diane Bender, Carlos Cruchaga, Oscar Harari, Andrea Bredemeyer, Kory Lavine, Ron Bose, Julie Margenthaler, Jason M Held, Samuel Achilefu, Foluso Ademuyiwa, Rebecca Aft, Cynthia Ma, Graham A Colditz, Stephen T Oh, James Fitzpatrick, Kooresh I Shoghi, Milan G Chheda, Deborah J Veis, Feng Chen, Ryan C Fields, William E Gillanders, Li Ding, Et Al.

2020-Current year OA Pubs

Breast cancer (BC) is defined by distinct molecular subtypes with different cells of origin. The transcriptional networks that characterize the subtype-specific tumor-normal lineages are not established. In this work, we applied bulk, single-cell and single-nucleus multi-omic techniques as well as spatial transcriptomics and multiplex imaging on 61 samples from 37 patients with BC to show characteristic links in gene expression and chromatin accessibility between BC subtypes and their putative cells of origin. Regulatory network analysis of transcription factors underscored the importance of BHLHE40 in luminal BC and luminal mature cells and KLF5 in basal-like tumors and luminal progenitor cells. Furthermore, …

Posttreatment Surveillance Intensity And Overall Survival In Prostate Cancer Survivors (Aft-30), Ronald C Chen, Ramsankar Basak, Stacie Dusetzina, Deborah S Usinger, Zahed Mohammed, Aaron D Falchook, Jessica R Schumacher, Amanda B Francescatti, Amanda Cuddy, George J Chang, Benjamin D Kozower, Caprice C Greenberg, Anne K Barber, Aaron J Katz

2020-Current year OA Pubs

BACKGROUND: Posttreatment surveillance affects millions of cancer survivors, but empiric data to guide clinical practice are lacking. This study assessed whether the intensity of surveillance testing after radical prostatectomy or radiation therapy for localized prostate cancer is associated with overall survival.

METHODS: Men diagnosed with localized prostate cancer between 2005 and 2010 who underwent radical prostatectomy or radiation therapy at a Commission on Cancer-accredited facility were randomly sampled. Primary data collected from 10 147 patients sampled across 1007 facilities were linked with existing data from the National Cancer Database. Analysis examined whether intensity of surveillance measured as the number of …

Essentials Of Genomics In Nursing Undergraduate Education: A Discussion Paper, Sarah L. Dewell, Kathleen A. Muglia, Letitia Y. Graves, Rachel Joseph, Kara L. Mangold, Laura Grayson Roselli, Anne L. Ersig, Trina K. Walker

College of Nursing Faculty Research and Publications

Aim

To map the 2021 American Association of Colleges of Nursing Essentials to the American Nurses Association Essentials of Genomic Nursing for all nurses and provide resources for nursing faculty to support the seamless integration of genomics into existing undergraduate curricula.

Background

Since the completion of the Human Genome Project in 2003, rapid advancements in genomic science leading to practical applications of genomics have revolutionized all areas of healthcare. Nursing is built on foundational life sciences, including genomics. As the largest segment of the healthcare workforce, who spend the most time with patients and families, nurses play a critical role …

Anti-Egfr Aptamer Exhibits Direct Anti-Cancer Effects In Nsclc Cells Harboring Egfr L858r Mutations, Brian J. Thomas, Sania Z. Awan, Trupti Joshi, Mark A. Daniels, David Porciani, Donald H. Burke

Biomedical Sciences

Non-small cell lung cancer (NSCLC) adenocarcinoma (LUAD) is a leading cause of death worldwide. Activating mutations in the tyrosine kinase domain of the oncogene epidermal growth factor receptor (EGFR) are responsible for ~10–50% of all LUAD cases. Although tyrosine kinase inhibitors (TKIs) have been effective in prolonging patient survival and quality of life, acquired resistance and disease progression are inevitable, presenting a clear unmet need for alternative or adjuvant therapeutics. Here we show that an anti-EGFR aptamer (EGFRapt) decreases viability and tumor growth of LUAD cell lines harboring the L858R ± T790M mutation in EGFR. Additionally, we elucidate …

Small And Long Non-Coding Rna Analysis For Humantrophoblast-Derived Extracellular Vesicles And Their Effect On The Transcriptome Profile Of Human Neural Progenitor Cells, Jessica A. Kinkade, Pallav Singh, Mohit Verma, Teka Khan, Toshihoko Ezashi, Nathan J. Bivens, R. Michael Roberts, Trupti Joshi, Cheryl S. Rosenfeld

Biomedical Sciences

In mice, the fetal brain is dependent upon the placenta for factors that guide its early development. This linkage between the two organs has given rise to the term, the placenta–brain axis. A similar interrelationship between the two organs may exist in humans. We hypothesize that extracellular vesicles (EVs) released from placental trophoblast (TB) cells transport small RNA and other informational biomolecules from the placenta to the brain where their contents have pleiotropic effects. Here, EVs were isolated from the medium in which human trophoblasts (TBs) had been differentiated in vitro from induced pluripotent stem cells (iPSC) and from cultured …

Transmembrane Protein 53 Craniotubular Dysplasia (Omim # 619727): The Skeletal Disease And Consequent Blindness Of This New Disorder, Michael P Whyte, Robert S Weinstein, Paul H Phillips, William H Mcalister, Raghuhr H Ramakrishnaiah, G Bradley Schaefer, Rongsheng Cai, Michele R Hutchison, Shenghui Duan, Gary S Gottesman, Steven Mumm

2020-Current year OA Pubs

Craniotubular dysplasia, Ikegawa type (OMIM #619727) denotes the autosomal recessive skeletal disease identified in 2021 featuring blindness acquired in childhood. Five young members of four Indian families harbored a homozygous indel within TMEM53 (OMIM *619722), the gene that encodes transmembrane protein 53 (TMEM53). When intact, TMEM53 spans the nuclear envelope of osteoprogenitor cells, dampens BMP-SMAD signaling, and thereby slows bone formation. Consequently, defective TMEM53 accelerates osteogenesis. Herein, an American boy is compound heterozygous for a novel deletion and a novel missense mutation within TMEM53. His vision and sensorineural hearing became impaired. Radiographic survey revealed diploic thickening of his skull, broad …

The Intersection Of Substance Use Stigma And Anti-Black Racial Stigma: A Scoping Review, Rashmi Ghonasgi, Maria E Paschke, Rachel P Winograd, Catherine Wright, Eva Selph, Devin E Banks

2020-Current year OA Pubs

BACKGROUND: Substance use stigma poses a barrier to treatment and recovery from substance use disorder. Stigma is amplified when intersecting with other stigmatized identities, particularly Black racial identity. Despite increasing attention to the intersecting roles of racial and substance use stigma, it is unknown how these stigmas interact to impact treatment and health outcomes among Black people who use drugs. This scoping review examines empirical research documenting differential impacts of race and racism on substance use stigma.

METHODS: We systematically searched PsychInfo and PubMed databases. Eligible studies were conducted in the U.S.; examined a Black sample, subsample, or experimental condition/variable …

Physiochemical, Bio, Thermal, And Non-Thermal Processing Of Major And Minor Millets: A Comprehensive Review On Antinutritional And Antioxidant Properties, Suhan Bheemaiah Balyatanda, N.A. Nanje Gowda, Jeyamkondan Subbiah, Snehasis Chakraborty, P.V. Vara Prasad, Kaliramesh Siliveru

Food Science Faculty Publications and Presentations

Millets are recognized as future foods due to their abundant nutrition and resilience, increasing their value on the global stage. Millets possess a broad spectrum of nutrients, antinutrients, and antioxidants, making it imperative to understand the effects of various processing methods on these components. Antinutritional factors interfere with the digestibility of macro-nutrients and the bioavailability and bio accessibility of minerals. This necessitates methods to reduce or eliminate antinutrients while improving nutritive and antioxidant value in food. This review aims to elucidate the rationale behind processing choices by evaluating the scientific literature and examining the mechanisms of processing methods, categorized as …

Influence Of Physical Activity Measurement On The Association Between Life's Essential 8 And Incident Cardiovascular Disease In Older Women, Eric T Hyde, Steve Nguyen, Michael J Lamonte, Chongzhi Di, John Bellettiere, Lesley F Tinker, Randi E Foraker, Hilary A Tindle, Marcia L Stefanick, Andrea Z Lacroix

2020-Current year OA Pubs

OBJECTIVE: The American Heart Association's Life's Essential 8 (LE8) metric includes self-reported physical activity as one of the metrics for assessing cardiovascular health. Self-reported physical activity is prone to misclassification, whereas accelerometer measures are less biased. We examined associations of LE8 and incident cardiovascular disease (CVD) using self-reported and accelerometer-measured physical activity.

METHODS: Participants in the Women's Health Initiative (WHI) Objective Physical Activity and Cardiovascular Health Study (n = 4,243; mean age = 79 ± 7 years) with no CVD history completed the WHI physical activity questionnaire and the Community Healthy Activities Model Program for Seniors (CHAMPS) questionnaire prior to …

Unh’S Field Hockey Win!, Grace Eveleigh

Digital Edition

An independent student produced newspaper from the University of New Hampshire.

Palestine Solidarity Coalition (Psc) Protests Unh Foundation Board’S Meeting, Chandler Blaisdell

Digital Edition

An independent student produced newspaper from the University of New Hampshire.

Lobstermen Are Scientists, Too., Emma Kostyun

Digital Edition

An independent student produced newspaper from the University of New Hampshire.

Ud In The News Oct. 26-Nov. 1, University Of Dayton

News Releases

Students were on The Briefing with Steve Scully on SiriusXM to discuss their class where they write campaign memos. Local media featured hands-on learning opportunities for students, a grant to help disabled children connect with religion, and more.

Variation In Provider Specialization Among 139 Non-Affiliated Real-World Data Contributors, Joshua Koni, Rose Reynolds, Janelle R. Noel-Macdonnell, Mark A. Hoffman

Posters

Oracle EHR Real-World Data (OERWD) is a national de-identified data set useful for observational findings across 139 non-affiliated healthcare systems. Data in OERWD is associated with a de-identified provider ID categorized and documented using National Uniform Claim Committee (NUCC) taxonomy codes. There are 2,421,948 providers in OERWD associated with both their specialty and contributing organization. We profile the data for overall distribution and co-occurrence of specialties, enabling research related to treatment patterns and outcomes.

A Survey Of Jamaica Constabulary Force Officers’ Opinions About Juveniles, The Causes Of Delinquency And Self-Legitimacy, Sh -Shanna Ellington

All Dissertations

This study explored the perceptions of Jamaica Constabulary Force (JCF) officers regarding juveniles, the causes of juvenile delinquency, and their self-legitimacy. It examined whether these perceptions were influenced by demographic factors such as police officers’ age, gender, rank, years of service, age at entry into the police force, educational level, and divisional classification. Additionally, it investigated the relationship between officers' perceptions of juveniles, causes of juvenile delinquency and their sense of self-legitimacy.

Previous research had extensively studied juvenile delinquency, causes of juvenile delinquency and police legitimacy, but there remained a significant gap in understanding how Jamaica police officers’ demographics influenced …

2020 Nasig Mid-Year Committee Reports

NASIG Newsletter

No abstract provided.

The President’S Column, Crystal Gates

The Southeastern Librarian

No abstract provided.

Southeastern Librarian 72(3) Fall 2024 (Full Issue)

The Southeastern Librarian

Complete issue of The Southeastern Librarian Volume 72 Number 3