Digital Commons Network^™

Obesity And Outcomes In Adoptive Cellular Therapy In Solid Tumors, Derrick L Tao, Mirella Nardo, Cheuk Hong Leung, Heather Y Lin, Lei Kang, Hung Le, Ecaterina E Dumbrava, David S Hong

Faculty, Staff and Student Publications

This cohort study investigates the association of obesity with adoptive cell therapy outcomes in patients with solid tumors.

Patient-Reported Convenience And Effectiveness Of Telehealth For Breast Cancer Management, Akshara Singareeka Raghavendra, Kristofer Jennings, Gil Guerra, Debu Tripathy, Meghan S Karuturi

Faculty, Staff and Student Publications

Background: Before the coronavirus disease 2019 (COVID-19) pandemic, telehealth was rarely used for breast cancer management at tertiary care centers. We sought to examine patient satisfaction, experiences, preferences, and perceived effectiveness and technical quality of telehealth visits in follow-up patients receiving routine outpatient care in the breast medical oncology practice at The University of Texas MD Anderson Cancer Center.

Methods: We administered a survey to 60 follow-up patients for a duration of 9 months (January 5, 2021 to October 27, 2021) who had at least one telehealth consultation during the COVID-19 pandemic, from April 10, 2020 to October 21, 2021. …

Fc-Enhanced Anti-Ctla-4, Anti-Pd-1, Doxorubicin, And Ultrasound-Mediated Blood-Brain Barrier Opening: A Novel Combinatorial Immunotherapy Regimen For Gliomas, Kwang-Soo Kim, Karl Habashy, Andrew Gould, Junfei Zhao, Hinda Najem, Christina Amidei, Ruth Saganty, Víctor A Arrieta, Crismita Dmello, Li Chen, Daniel Y Zhang, Brandyn Castro, Leah Billingham, Daniel Levey, Olivia Huber, Marilyn Marques, David A Savitsky, Benjamin M Morin, Miguel Muzzio, Michael Canney, Craig Horbinski, Peng Zhang, Jason Miska, Surya Padney, Bin Zhang, Raul Rabadan, Joanna J Phillips, Nicholas Butowski, Amy B Heimberger, Jian Hu, Roger Stupp, Dhan Chand, Catalina Lee-Chang, Adam M Sonabend

Faculty, Staff and Student Publications

Background: Glioblastoma is a highly aggressive brain cancer that is resistant to conventional immunotherapy strategies. Botensilimab, an Fc-enhanced anti-CTLA-4 antibody (FcE-aCTLA-4), has shown durable activity in "cold" and immunotherapy-refractory cancers.

Methods: We evaluated the efficacy and immune microenvironment phenotype of a mouse analogue of FcE-aCTLA-4 in treatment-refractory preclinical models of glioblastoma, both as a monotherapy and in combination with doxorubicin delivered via low-intensity pulsed ultrasound and microbubbles (LIPU/MB). Additionally, we studied 4 glioblastoma patients treated with doxorubicin, anti-PD-1 with concomitant LIPU/MB to investigate the novel effect of doxorubicin modulating FcγR expressions in tumor-associated macrophages/microglia (TAMs).

Results: FcE-aCTLA-4 demonstrated high-affinity binding …

Thrombosis, Brain Metastasis Formation, And The Perivascular Metastatic Niche-Novel Insights From The Tumor Microvascular Circulation, Christopher Alvarez-Breckenridge, Priscilla K Brastianos, Daniel P Cahill

Faculty, Staff and Student Publications

No abstract provided.

The Emerging Field Of Viroimmunotherapy For Pediatric Brain Tumors, Marc Garcia-Moure, Virginia Laspidea, Sumit Gupta, Andrew G Gillard, Soumen Khatua, Akhila Parthasarathy, Jiasen He, Frederick F Lang, Juan Fueyo, Marta M Alonso, Candelaria Gomez-Manzano

Faculty, Staff and Student Publications

Pediatric brain tumors are the most common solid tumors in children. Even to date, with the advances in multimodality therapeutic management, survival outcomes remain dismal in some types of tumors, such as pediatric-type diffuse high-grade gliomas or central nervous system embryonal tumors. Failure to understand the complex molecular heterogeneity and the elusive tumor and microenvironment interplay continues to undermine therapeutic efficacy. Developing a strategy that would improve survival for these fatal tumors remains unmet in pediatric neuro-oncology. Oncolytic viruses (OVs) are emerging as a feasible, safe, and promising therapy for brain tumors. The new paradigm in virotherapy implies that the …

Impa1-Derived Inositol Maintains Stemness In Castration-Resistant Prostate Cancer Via Impdh2 Activation, Che-Chia Hsu, Guihua Wang, Chien-Feng Li, Xian Zhang, Zhen Cai, Tingjin Chen, Bo-Syong Pan, Rajesh Kumar Manne, Gagan Deep, Haiwei Gu, Yuzhuo Wang, Danni Peng, Vasudevarao Penugurti, Xiaobo Zhou, Zhigang Xu, Zhongzhu Chen, Ming Chen, Andrew J Armstrong, Jiaoti Huang, Hong-Yu Li, Hui-Kuan Lin

Faculty, Staff and Student Publications

Acquisition of prostate cancer stem cells (PCSCs) manifested during androgen ablation therapy (ABT) contributes to castration-resistant prostate cancer (CRPC). However, little is known about the specific metabolites critically orchestrating this process. Here, we show that IMPA1-derived inositol enriched in PCSCs is a key metabolite crucially maintaining PCSCs for CRPC progression and ABT resistance. Notably, conditional Impa1 knockout in the prostate abrogates the pool and properties of PCSCs to orchestrate CRPC progression and prolong the survival of TRAMP mice. IMPA1-derived inositol serves as a cofactor that directly binds to and activates IMPDH2, which synthesizes guanylate nucleotides for maintaining PCSCs with ARlow/- …

Laparoscopic Cytoreduction After Neoadjuvant Chemotherapy In High-Grade Epithelial Ovarian Cancer: A Lance Randomized Clinical Trial, J Alejandro Rauh-Hain, Alexander Melamed, René Pareja, Taymaa May, Abdulrahman Sinno, Leah Mcnally, Neil S Horowitz, Pierandrea De Iaco, Chad M Michener, Luc Van Lonkhuijzen, Maria D Iniesta, Ying Yuan, Pedro T Ramirez, Anna Fagotti

Faculty, Staff and Student Publications

Importance: Despite the absence of high-quality evidence of its safety and effectiveness, minimally invasive surgery (MIS) is increasingly used to treat advanced epithelial ovarian cancer (EOC).

Objective: To assess the feasibility of conducting a full-scale randomized clinical trial (RCT) designed to compare the efficacy of MIS vs laparotomy in patients with advanced-stage EOC and a complete or partial response to neoadjuvant chemotherapy (NACT).

Design, setting, and participants: This lead-in pilot phase of LANCE (Laparoscopic Cytoreduction After Neoadjuvant Chemotherapy), an international, open-label, noninferiority RCT, opened to enrollment in September 2020 and enrolled the 100th eligible patient in February 2023. It was …

Intrapartum And 30-Day Postpartum Complications In Patients With Antenatal Covid-19 Infection: A Retrospective Cohort Study, Sriya Donthi, Jacqueline Kloos, Kelly S. Gibson, David C. Kaelber

Student Scholarship

Objective: The study was aimed at comparing intrapartum and postpartum outcomes between pregnant patients with and without antenatal COVID-19 infection using aggregated, deidentified electronic health record (EHR) data. Design and Setting: This retrospective cohort study included data from over 80 health care organizations within the TriNetX Analytics Research Network. Population: Individuals admitted for delivery from Jan 2020 to May 2023 were studied. Methods: We studied individuals with ICD-10 codes for delivery, COVID-19 diagnosis, and primary outcomes. We compared the incidence of adverse intrapartum and 30-day postpartum outcomes in those with and without antenatal COVID-19. Main Outcome Measures: The main outcomes …

Strategies To Reduce Diagnostic Laboratory Technologist Shortages In Veterans Health Administration Hospitals, Leke Abiodun Ayanbukola

Walden Dissertations and Doctoral Studies

The Veterans Health Administration (VHA) faces historically high turnover in diagnostic laboratory operations due to burnout resulting from the increases in testing and staffing issues. The purpose of this integrative review was to determine strategies to reduce laboratory technologists’ burnout, lessen the turnover effect, and increase the retention of VHA laboratory technologists. The review question focused on strategies related to actions that could be implemented to improve retention for laboratory technologists. A literature search of both empirical and non-empirical literature for the past five years yielded a total of 98 articles that qualified for the project. After further analysis, 25 …

Federally Qualified Health Center Access To Maternity Care For Incarcerated Pregnant Women, Pamela Baldwin

Walden Dissertations and Doctoral Studies

Background: There has been an increase in pregnant incarcerated women, which is a growing concern for this high-risk and special population. This specialty group indicates a need for attention to ensure access to timely and proper medical care. Incarcerated pregnant women are a noted vulnerable group and do not have access to standardized clinical guidelines. Imprisonment imposes unique restrictions regarding access to care. A Federally Qualified Health Center (FQHC) in Pennsylvania has been providing ambulatory/obstetrics and gynecology (OBGYN) care to incarcerated pregnant women. Purpose: This research aimed to investigate strategies FQHC leadership can use to improve access to care for …

Predictive Validity Of Person-Environment Fit On The Hiring Desirability Of Software Engineers, Lucija Velican

Walden Dissertations and Doctoral Studies

Person-environment (P-E) fit, particularly in recruitment, has gained significant attention, expanding beyond the traditional focus on job-applicant compatibility to include alignment with team and organizational dynamics. Despite its importance, there is no consensus on how to effectively measure this fit, which limits its predictive power for employee outcomes. This quantitative correlational study addressed this gap by examining the predictive validity of congruence between candidates’ psychological characteristics and various facets of the work environment among software engineers. Drawing on Schneider’s attraction-selection-attrition model, the study examined congruence at multiple levels (candidate-team, candidate-leader, and candidate-role) and its influence on hiring desirability. Secondary data …

Predictive Validity Of Person-Environment Fit On The Hiring Desirability Of Software Engineers, Lucija Velican

Walden Dissertations and Doctoral Studies

Person-environment (P-E) fit, particularly in recruitment, has gained significant attention, expanding beyond the traditional focus on job-applicant compatibility to include alignment with team and organizational dynamics. Despite its importance, there is no consensus on how to effectively measure this fit, which limits its predictive power for employee outcomes. This quantitative correlational study addressed this gap by examining the predictive validity of congruence between candidates’ psychological characteristics and various facets of the work environment among software engineers. Drawing on Schneider’s attraction-selection-attrition model, the study examined congruence at multiple levels (candidate-team, candidate-leader, and candidate-role) and its influence on hiring desirability. Secondary data …

Social Workers' Challenges And Successes In Working With Black Men During Times Of Social Upheaval., Eric Dewayne Franklin

Walden Dissertations and Doctoral Studies

U.S. social workers experienced challenges and successes when working with Black male clients in mental and medical health and addiction therapy or treatment settings before and during the simultaneous events of the COVID-19 pandemic, political elections, and racial violence/social injustice movements of the late 2010s–early 2020s. This project addressed the lack of knowledge regarding evidence-based practices to address the challenges and positive therapeutic experiences of social workers, specifically those working in clinical practice with Black American male clients. The theoretical framework for this study was Bell's critical race theory. The generic qualitative research design was used to address three research …

Strategies To Reduce Employee Turnover In The Insurance Industry In Jamaica, Kenneth Barrington Roberts

Walden Dissertations and Doctoral Studies

High employee turnover in insurance agencies can have a detrimental effect on overall team performance and significantly impact on the organization's financial health. To address the problem, insurance managers must understand effective strategies to improve employee retention. Grounded in Herzberg’s two-factor theory, the purpose of this qualitative pragmatic inquiry was to explore strategies insurance managers use to reduce their employee turnover rate. The participants were three insurance managers of the Jamaican insurance industry. Data were collected using semistructured virtual interviews and a review of public documents related to turnover data. Through thematic analysis, three themes emerged: a) supportive leadership for …

Restoring And Improving Senior Citizens' Trust In Water Safety In Flint, Michigan, Jessica Nichole Burt

Walden Dissertations and Doctoral Studies

Trust can be defined as a belief in truth, hope, or simply the idea that a person or group has the best interest or ability of the next party. During the Flint, Michigan, water crisis, trust significantly impacted how a person or group perceived the person deemed dependable when decisions made impacted their life. The purpose of this study was to explore senior citizens' experiences and perceptions and make recommendations for restoring the public's confidence in water safety in Flint, Michigan, which has been fragmented within the minority senior community. A qualitative case study was designed by using interviews to …

Understanding The Demographic And Health Factors Associated With The Incidence Of Stroke In Jamaica, Zandy Elliott

Walden Dissertations and Doctoral Studies

Stroke, the leading cause of death and disability worldwide, is a significant public health issue in Jamaica, affecting individuals, families, and the healthcare system. This study identified demographic and health factors associated with stroke, enabling medical professionals to better understand high-risk factors and implement preventative care strategies in Jamaica—filling a significant gap in public health knowledge. The quantitative cross-sectional study examined Jamaican demographics, health, and stroke rates. Secondary data from the Office of the Consultant Neurologist (OCN) from 2000-2023 was integrated into the Social Ecological Model (SEM). The study included 291 stroke patients aged 18 and older, excluding those under …

Napoleon Young

African American Funeral Programs

No abstract provided.

Mr. Eugene Rawls

African American Funeral Programs

Mr_Eugene_Rawls_Sr.pdf - Funeral program for Mr. Eugene Rawls

Transcranial Direct Current Stimulation Combined With Repetitive Transcranial Magnetic Stimulation For Depression: A Randomized Clinical Trial, Dongsheng Zhou, Xingxing Li, Shuochi Wei, Chang Yu, Dongmei Wang, Yuchen Li, Jiaxin Li, Junyao Liu, Shen Li, Wenhao Zhuang, Yanli Li, Ruichenxi Luo, Zhiwang Liu, Jimeng Liu, Yongming Xu, Jialin Fan, Guidong Zhu, Weiqian Xu, Yiping Tang, Raymond Y Cho, Thomas R Kosten, Xiang-Yang Zhang

Staff and Researcher Publications

IMPORTANCE: Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are both recognized as effective treatments for depression when applied individually. However, it is unknown whether rTMS combined with tDCS has better efficacy in the treatment of major depressive disorder (MDD).

OBJECTIVE: To investigate the clinical effectiveness and safety of rTMS, tDCS, tDCS + rTMS, and sham tDCS + sham rTMS after 2 weeks of treatment in patients with MDD.

DESIGN, SETTING, AND PARTICIPANTS: This double-blind, sham-controlled randomized clinical trial was conducted from November 2021 to April 2023 at 3 hospitals in China (Kangning Hospital affiliated with Ningbo …

Transport Of Β-Amyloid From Brain To Eye Causes Retinal Degeneration In Alzheimer’S Disease, Qiuchen Cao, Shige Yang, Xiaowei Wang, Huaiqing Sun, Weijie Chen, Yuliang Wang, Junying Gao, Yanchi Wu, Qiuhua Yang, Xue Chen, Songtao Yuan, Ming Xiao, Maiken Nedergaard, Yuqing Huo, Qinghuai Liu

Faculty, Staff and Students Publications

The eye is closely connected to the brain, providing a unique window to detect pathological changes in the brain. In this study, we discovered β-amyloid (Aβ) deposits along the ocular glymphatic system in patients with Alzheimer's disease (AD) and 5×FAD transgenic mouse model. Interestingly, Aβ from the brain can flow into the eyes along the optic nerve through cerebrospinal fluid (CSF), causing retinal degeneration. Aβ is mainly observed in the optic nerve sheath, the neural axon, and the perivascular space, which might represent the critical steps of the Aβ transportation from the brain to the eyes. Aquaporin-4 facilitates the influx …

Improving Risk Stratification For 2022 European Leukemianet Favorable-Risk Patients With Acute Myeloid Leukemia, Kellie J Archer, Geoffrey L Uy, Et Al.

2020-Current year OA Pubs

Assignment of patients diagnosed with acute myeloid leukemia (AML) to the 2022 European LeukemiaNet (ELN) favorable genetic risk group has important clinical implications, as allogeneic stem cell transplantation in first complete remission (CR) is not advised due to a relatively good outcome of patients receiving chemotherapy alone and transplant-associated mortality. However, not all favorable genetic risk patients experience long-term relapse-free survival (RFS), making recognition of patients who would most likely be cured of high importance. We analyzed 297 patients aged < 60 years with

Staff Education Project To Train Providers On The Use Of The Sbar Communication Tool To Improve Reimbursement Rates, Teona Natoya Eririogu

Walden Dissertations and Doctoral Studies

In this doctoral project, I focused on educating healthcare staff on using the situation-background-assessment-recommendation (SBAR) communication tool to improve documentation practices and reimbursement rates from Medicare, Medicaid, and private insurance companies. My goal for the project was to determine if training on the SBAR tool would improve healthcare providers' knowledge of how to use it for documentation. The facility had experienced significant financial losses, exceeding $1 million in the last two quarters of 2023, due to inadequate documentation. Inaccurate or incomplete documentation, particularly in medical records, hinders the ability to bill appropriately for services rendered, impacting patient care and financial …

Theoretical And Numerical Investigation Of An Ultra-Broadband Near-Perfect Absorption In Auxetic Metamaterials, Md. Rezwan Ahmed, Oishi Jyoti,, Ferdous Farjana, Pritu P. Sarkar, Alok Kumar Paul, Md. Samiul Habib

Mechanical Engineering Faculty Publications

In this paper, we present and numerically investigate an auxetic metamaterial absorber based on vanadium dioxide (VO2), achieving more than 90% absorption of the incident terahertz (THz) waves between 4.15 THz to 8.43 THz with an average absorption of 98.4%. To our knowledge, the absorption bandwidth is higher than previously reported VO2-based absorbers. The proposed absorber contains two VO2 based resonator rings placed diagonally at the top of the dielectric substrate in such a way as to create an auxetic shape and provide more design space than the existing absorbers. Considering the vector nature of electromagnetic fields in three-dimensional space, …

Effectiveness Of Hybrid Project Management In Remote Work Environment, Karthikeyan Mohandoss

Harrisburg University Dissertations and Theses

This assignment reflects on the process of developing and publishing a thesis, highlighting the challenges encountered, strategies employed to overcome them, and the personal growth achieved throughout the journey. Key insights are drawn from the experience, including how the understanding of the research topic evolved over time and practical advice for future students embarking on similar academic endeavors. The document also provides evidence of initiating the thesis publication process on the Harrisburg University Digital Commons platform, demonstrating a crucial step in sharing scholarly work with a broader audience. This reflection emphasizes the transformative nature of the thesis process, fostering intellectual …

Dewitt Luxury Home Inc. V. Lewis

All Decisions

The landlord commenced a nonpayment proceeding against the rent-stabilized tenant, who also received Section 8 benefits. The landlord failed to plead the correct regulatory status of the apartment and failed to plead that the tenant received Section 8 benefits. The court denied the landlord's motion to amend the petition and granted the tenant's motion to dismiss, finding that the landlord's errors were fundamental and could not be corrected by amendment.

Data-Driven Cutoff Selection For The Patient Health Questionnaire-9 Depression Screening Tool, Brooke Levis, Parash Mani Bhandari, Dipika Neupane, Suiqiong Fan, Ying Sun, Chen He, Yin Wu, Ankur Krishnan, Zelalem Negeri, Mahrukh Imran, Danielle B Rice, Kira E Riehm, Marleine Azar, Alexander W Levis, Jill Boruff, Pim Cuijpers, Simon Gilbody, John P A Ioannidis, Lorie A Kloda, Scott B Patten, Roy C Ziegelstein, Daphna Harel, Yemisi Takwoingi, Sarah Markham, Sultan H Alamri, Dagmar Amtmann, Bruce Arroll, Liat Ayalon, Hamid R Baradaran, Anna Beraldi, Charles N Bernstein, Arvin Bhana, Charles H Bombardier, Ryna Imma Buji, Peter Butterworth, Gregory Carter, Marcos H Chagas, Juliana C N Chan, Lai Fong Chan, Dixon Chibanda, Kerrie Clover, Aaron Conway, Yeates Conwell, Federico M Daray, Janneke M De Man-Van Ginkel, Jesse R Fann, Felix H Fischer, Sally Field, Jane R W Fisher, Daniel S S Fung, Bizu Gelaye, Leila Gholizadeh, Felicity Goodyear-Smith, Eric P Green, Catherine G Greeno, Brian J Hall, Liisa Hantsoo, Martin Härter, Leanne Hides, Stevan E Hobfoll, Simone Honikman, Thomas Hyphantis, Masatoshi Inagaki, Maria Iglesias-Gonzalez, Hong Jin Jeon, Nathalie Jetté, Mohammad E Khamseh, Kim M Kiely, Brandon A Kohrt, Yunxin Kwan, Maria Asunción Lara, Holly F Levin-Aspenson, Shen-Ing Liu, Manote Lotrakul, Sonia R Loureiro, Bernd Löwe, Nagendra P Luitel, Crick Lund, Ruth Ann Marrie, Laura Marsh, Brian P Marx, Anthony Mcguire, Sherina Mohd Sidik, Tiago N Munhoz, Kumiko Muramatsu, Juliet E M Nakku, Laura Navarrete, Flávia L Osório, Brian W Pence, Philippe Persoons, Inge Petersen, Angelo Picardi, Stephanie L Pugh, Terence J Quinn, Elmars Rancans, Sujit D Rathod, Katrin Reuter, Alasdair G Rooney, Iná S Santos, Miranda T Schram, Juwita Shaaban, Eileen H Shinn, Abbey Sidebottom, Adam Simning, Lena Spangenberg, Lesley Stafford, Sharon C Sung, Keiko Suzuki, Pei Lin Lynnette Tan, Martin Taylor-Rowan, Thach D Tran, Alyna Turner, Christina M Van Der Feltz-Cornelis, Thandi Van Heyningen, Paul A Vöhringer, Lynne I Wagner, Jian Li Wang, David Watson, Jennifer White, Mary A Whooley, Kirsty Winkley, Karen Wynter, Mitsuhiko Yamada, Qing Zhi Zeng, Yuying Zhang, Brett D Thombs, Andrea Benedetti, Depression Screening Data (Depressd) Phq Group

Faculty, Staff and Students Publications

IMPORTANCE: Test accuracy studies often use small datasets to simultaneously select an optimal cutoff score that maximizes test accuracy and generate accuracy estimates.

OBJECTIVE: To evaluate the degree to which using data-driven methods to simultaneously select an optimal Patient Health Questionnaire-9 (PHQ-9) cutoff score and estimate accuracy yields (1) optimal cutoff scores that differ from the population-level optimal cutoff score and (2) biased accuracy estimates.

DESIGN, SETTING, AND PARTICIPANTS: This study used cross-sectional data from an existing individual participant data meta-analysis (IPDMA) database on PHQ-9 screening accuracy to represent a hypothetical population. Studies in the IPDMA database compared participant PHQ-9 …

Nerve Injury Inhibits Oprd1 And Cnr1 Transcription Through Rest In Primary Sensory Neurons, Ashok Subedi, Asieh Etemad, Aadhya Tiwari, Yuying Huang, Biji Chatterjee, Samantha M Mcleod, Yungang Lu, Diangelo Gonzalez, Krishna Ghosh, Mario Sirito, Sanjay K Singh, Elisa Ruiz, Sandra L Grimm, Cristian Coarfa, Hui-Lin Pan, Sadhan Majumder

Faculty, Staff and Students Publications

The transcription repressor REST in the dorsal root ganglion (DRG) is upregulated by peripheral nerve injury and promotes the development of chronic pain. However, the genes targeted by REST in neuropathic pain development remain unclear. The expression levels of four opioid receptor genes (Oprm1, Oprd1, Oprl1 and Oprk1) and the cannabinoid CB1 receptor (Cnr1) gene in the DRG regulate nociception. In this study, we determined the role of REST in controlling their expression in the DRG induced by spared nerve injury (SNI). SNI induced chronic pain hypersensitivity in wild-type mice and was accompanied by increased levels of Rest transcript and …

Actionable Structural Variant Detection Via Rns-Ngs And Dna-Ngs In Patients With Advanced Non-Small Cell Lung Cancer, Dwight Owen, Daniel Morgensztern, Et Al.

2020-Current year OA Pubs

IMPORTANCE: The National Comprehensive Cancer Network (NCCN) guidelines for non-small cell lung cancer suggest that RNA next-generation sequencing (NGS) may improve the detection of fusions and splicing variants compared with DNA-NGS alone. However, there is limited adoption of RNA-NGS in routine oncology clinical care today.

OBJECTIVE: To analyze clinical evidence from a diverse cohort of patients with advanced lung adenocarcinoma and compare the detection of NCCN-recommended actionable structural variants (aSVs; fusions and splicing variants) via concurrent DNA and RNA-NGS vs DNA-NGS alone.

DESIGN, SETTING, AND PARTICIPANTS: This multisite, retrospective cohort study examined patients sequenced between February 2021 and October 2023 …

Performance Of Risk Models For Antimicrobial Resistance In Adult Patients With Sepsis, M Cristina Vazquez Guillamet, Hanyang Liu, Andrew Atkinson, Victoria J Fraser, Chenyang Lu, Marin H Kollef

2020-Current year OA Pubs

IMPORTANCE: The results of prediction models that stratify patients with sepsis and risk of resistant gram-negative bacilli (GNB) infections inform treatment guidelines. However, these models do not extrapolate well across hospitals.

OBJECTIVE: To assess whether patient case mix and local prevalence rates of resistance contributed to the variable performance of a general risk stratification GNB sepsis model for community-onset and hospital-onset sepsis across hospitals.

DESIGN, SETTING, AND PARTICIPANTS: This was a retrospective cohort study conducted from January 2016 and October 2021. Adult patients with sepsis at 10 acute-care hospitals in rural and urban areas across Missouri and Illinois were included. …

Quality Of Publicly Available Information About Urinary Tract Infections, Viktoria Schmitz, Zoe Troubh, Michael Durkin, Kevin Hsueh, Katheryn Ney, Brian D Carpenter, Shinbee Waldron, Mary C Politi, Cdc Prevention Epicenters Program

2020-Current year OA Pubs

No abstract provided.