Digital Commons Network^™

Life Course Stressors, Latent Coping Strategies, Alcohol Use, And Adherence Among People With Hiv, Amrita Gill, Gretchen Clum, Patricia Molina, David Welsh, Tekeda Ferguson, Katherine P. Theall

School of Medicine Faculty Publications

People with HIV (PWH) have often experienced chronic stressors across their lifespan, including adverse childhood experiences (ACES), lifetime economic hardship (LEH), and concurrent stressors associated with living in urban areas (urban stress). Prolonged exposure to stressors might result in differential coping patterns among PWH that can impact care trajectories. We utilized a life course-informed approach to examine chronic stressors as antecedents of latent coping strategies among PWH in care. High-risk alcohol use and non-adherence to anti-retroviral therapy (ART) were examined as consequences of latent coping strategies. Data were utilized from the baseline and interim follow-up visit of the New Orleans …

Acute Stress Activates Basolateral Amygdala Neurons Expressing Corticotropin-Releasing Hormone Receptor Type 1 (Crhr1): Topographical Distribution And Projection-Specific Activation In Male And Female Rats, Robert J. Aukema, Gavin N. Petrie, Samantha L. Baglot, Nicholas W. Gilpin, Matthew N. Hill

School of Medicine Faculty Publications

Although the basolateral amygdala (BLA) and corticotropin releasing hormone receptor type I (CRHR1) signaling are both central to the stress response, the spatial and circuit-specific distribution of CRHR1 have not been identified in the BLA at a high resolution. We used transgenic male and female CRHR1-Cre-tdTomato rats to topographically map the distribution of BLA neurons and identify whether they are activated by acute stress. Additionally, we used the BLA circuits projecting to the central amygdala (CeA) and nucleus accumbens (NAc) as a model to test circuit-specific expression of CRHR1 in the BLA. We established several key findings. First, CRHR1 had …

Identifying Hidden Factors Influencing Soil Olsen-P In An Alkaline Calcareous Soil Using Machine Learning And Geostatistical Techniques, Moussa Bouray, Mohammed Bayad, Adnane Beniaich, Ahmed G. El-Naggar, Rebecca Muenich, Kahlil El Mejahed, Abdallah Oukarroum, Mohamed El Gharous

Biological and Agricultural Engineering Faculty Publications and Presentations

Phosphorus (P) deficiency is one of the major constraints for sustainable crop production in calcareous soils. This study aimed to elucidate the key soil characteristics modulating the variability of soil Olsen P in these typical soils. A comprehensive soil sampling initiative (1.5 samples per hectare) was conducted on a 100-ha farm, considering 31 attributes that included soil physical and chemical properties, and geographic attributes. Three machine learning algorithms—partial least squares regression (PLSR), random forest (RF), and cubist regression (CR)—were employed to understand key variables controlling soil Olsen P. Furthermore, the same data set was used to spatially map the …

Ultra-Relativistic Electron Flux Enhancement Under Persistent High Speed Solar Wind Stream, L R. Alves, L A. Da Silva, V Deggeroni, J P. Marchezi, P R. Jauer, G B D Silva, D G. Sibeck

Faculty Publications

The physical mechanisms usually applied to explain the relativistic electron enhancement have been delved into to elucidate non-adiabatic electron acceleration resulting in the ultra-relativistic electron population observed in the outer radiation belt. We considered multisatellite observations of the solar wind parameters, magnetospheric waves, and particle flux to report an unusual local acceleration of ultra-relativistic electrons under a prolonged high-speed solar wind stream (HSS). A corotating interaction region reaches the Earth’s bowshock on August 3, 2016, causing a minor geomagnetic storm. Following this, the magnetosphere was driven for 72 h by a long-term HSS propagating at 600 km/s. During this period, …

Ionic Nanomedicines And Biocompatible Hydrogel: Synthesis, Characterization And Application In Cancer And Drug Delivery, Mujeebat Bashiru

Theses and Dissertations

This dissertation is focused on the development of novel class of ionic materials (IMs), and ionic nanomedicines (INMs) for cancer treatment. These IMs are composed of two therapeutics combined via electrostatic attraction. The impact of various counterions on the drug’s cytotoxic and photophysical properties are unveiled. Moreover, the mechanism of internalization, enhanced toxicity of these materials is investigated by determining their cellular uptake, subcellular localization, and cell death mechanism. Furthermore, the in vivo bioimaging capabilities of the drugs is investigated to validate their potential for clinical relevance. The second part of this dissertation is focused on the synthesis of biocompatible …

Healing Online Abuse Through Community-Based Art: An Exploratory Investigation, Sarah Auletta

Sociology Between the Gaps: Forgotten and Neglected Topics

No abstract provided.

Bonnie Peragallo V. W&T Holdings And Jason Laursen : Reply Brief, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

APPEAL FROM THE FIRST JUDICIAL DISTRICT COURT FOR CACHE COUNTY, STATE OF UTAH HONORABLE SPENCER WALSH

ROBERT JANICKI MATTHEW JONES STRONG AND HANNI Counsel for Appellee

PETER R. MIFFLIN – 12595 ROBERT J. DEBRY & ASSOCIATES Counsel for Appellant

Moderating Effect Of Urban/Rural Status, State Of Residence, And Health Risk Factors On Maternal Mortality Among Different Races, Emmanuel Agubata

Walden Dissertations and Doctoral Studies

Maternal mortality in the United States is significantly higher than in most developed nations and has been increasing since 2000. Persistent between-group disparities among White, Black, and Hispanic women occur in terms of maternal mortality; however, the reason for this is largely unknown. Using the intersectionality theory, this quantitative study examined if racial groups predicted maternal mortality and to what extent relationships were moderated by geographic area and health risk factors. This nonexperimental correlational historical research design addressed three research questions. The Healthcare Cost and Utilization Project dataset was used for the analysis. The minimum sample size was 988 cases, …

Understanding Teachers’ Perceptions Of Best Practices For English Language Learners, Joshua Daniel Davis

Walden Dissertations and Doctoral Studies

In a district where only 5% of ELLs were deemed language proficient, the problem was the need to understand teacher perceptions of best practices to increase English language learner (ELL) achievement in reading and writing. The purpose of this qualitative study was to examine teacher perceptions of best practices to support ELLs in improving their reading and writing in a heterogeneous high school classroom in a Mid-Atlantic school district. The framework that supported this study was the Cummins model on learners’ language use because it guides teaching and assessing students’ vocabulary acquisition in various contexts. The two research questions probed …

Teaching Sbirt To Nurses In A Mental Health Setting For Improved Assessment And Management Of Patients With Substance Use Disorders, Kifle Gashie Jikamo

Walden Dissertations and Doctoral Studies

Addressing the knowledge gap is essential in nursing practice, as RNs are the first point of contact for patients in mental health settings where substance use significantly influences overall health and recovery. This Doctor of Nursing Practice project focused on the need for staff education in an inpatient mental health unit regarding the assessment and triage of patients with substance use disorders (SUDs). The guiding question for this project was: “In nurses working within an inpatient mental health setting, does the implementation of Screening, Brief Intervention, and Referral to Treatment (SBIRT) training improve knowledge in assessing, managing, and providing care …

Improving The Department Of Veterans Affairs Medical Centers Electronic Health Record Implementation, Rodney James Laster

Walden Dissertations and Doctoral Studies

Implementing electronic health records (EHR) is critical for modernizing healthcare systems; however, existing research has indicated these initiatives are fraught with challenges. The Department of Veterans Affairs (VA) is responsible for providing care to millions of veterans and has encountered significant obstacles in its EHR modernization efforts, leading to budget overruns, extended timelines, and operational disruptions. EHR implementations within the VA are particularly complex due to underestimated costs, lengthy schedules, and unforeseen organizational hurdles. As a result, the VA’s EHR project has faced numerous setbacks, including delays and pauses in future deployments, creating a pressing need for effective strategies to …

The Experiences Of Veteran African American Military Officers With Social Influences On Promotions And Career Opportunities, Veronica Denise Green

Walden Dissertations and Doctoral Studies

While programs and procedures are in place in the US Military to increase diversity and inclusion of minorities and women in senior level positions, the problem is African Americans continue to remain below the relative national percentage rate compared to their White male counterparts. The purpose of this qualitative multiple case study was to explore African American veteran Military officers' experiences with promotion and access to career opportunities, and to identify how their social and cultural relationships influenced those opportunities. Khawaja’s theory of workplace relationships provided a lens into the key role of relationships in organizational conflict, teamwork, and inclusion …

Improving Employee Retention In The Virtual Workforce, Marissa Williams

Walden Dissertations and Doctoral Studies

The need for addressing employee retention in the virtual workforce is critical, particularly in the context of the U.S. General Services Administration (GSA) Region 4. High employee turnover rates can lead to significant disruptions and decreased organizational performance. This administrative case study involved identifying effective strategies to improve retention and engagement among virtual employees. The practice-focused question involved understanding key factors that influenced employee retention and developing actionable recommendations for the GSA. Insights can be applied across similar organizations facing virtual workforce challenges. Data were collected through in-depth surveys with employees that were hired between 2020 and 2023, focusing on …

Understanding Teachers’ Perceptions Of Best Practices For English Language Learners, Joshua Daniel Davis

Walden Dissertations and Doctoral Studies

In a district where only 5% of ELLs were deemed language proficient, the problem was the need to understand teacher perceptions of best practices to increase English language learner (ELL) achievement in reading and writing. The purpose of this qualitative study was to examine teacher perceptions of best practices to support ELLs in improving their reading and writing in a heterogeneous high school classroom in a Mid-Atlantic school district. The framework that supported this study was the Cummins model on learners’ language use because it guides teaching and assessing students’ vocabulary acquisition in various contexts. The two research questions probed …

The Perceptions Of Law Enforcement Officers In Combating Carjacking And Auto Theft During The Covid-19 Pandemic, Daniel L. Gray

Walden Dissertations and Doctoral Studies

The purpose of this qualitative study was to explore law enforcement officers’ perceptions in combating carjacking and auto theft during the COVID-19 pandemic in the southeast region of Louisiana. The framework selected to guide the study was the crime pattern theory by Brangtingham and Brangtinham. Using the purposive sampling method and snowballing sampling method, 10 active law enforcement officers were recruited from agencies across the Southeast region of Louisiana until data saturation occurred. The research questions focused on perceptions of law enforcement officers in combating carjacking and auto theft during the COVID-19 pandemic. Strategies used and preparedness to combat carjacking …

The Experiences Of Veteran African American Military Officers With Social Influences On Promotions And Career Opportunities, Veronica Denise Green

Walden Dissertations and Doctoral Studies

While programs and procedures are in place in the US Military to increase diversity and inclusion of minorities and women in senior level positions, the problem is African Americans continue to remain below the relative national percentage rate compared to their White male counterparts. The purpose of this qualitative multiple case study was to explore African American veteran Military officers' experiences with promotion and access to career opportunities, and to identify how their social and cultural relationships influenced those opportunities. Khawaja’s theory of workplace relationships provided a lens into the key role of relationships in organizational conflict, teamwork, and inclusion …

Long-Term Follow-Up Of Levonorgestrel Intrauterine Device For Atypical Hyperplasia And Early Endometrial Cancer Reveals Relapse Characterized By Immune Exhaustion, Mikayla B Bowen, Brenda Melendez, Qian Zhang, Richard K Yang, Bryan M Fellman, Barrett C Lawson, Naomi N Adjei, Joseph Celestino, Khalida M Wani, Bhavana Singh, Diana L Urbauer, Alexander J Lazar, Karen H Lu, Jennifer A Wargo, Shannon N Westin, Melinda S Yates

Faculty, Staff and Student Publications

Purpose: Nonsurgical treatment options are increasingly needed for endometrial atypical hyperplasia (AH) and endometrioid endometrial cancer (EEC). Despite promising initial response rates, prospective long-term data and determinants for relapse are limited.

Materials and methods: Follow-up data from patients in our prospective phase II trial of levonorgestrel intrauterine device (LIUD) for AH/G1EEC were collected from medical records. Spatial transcriptomics (Nanostring GeoMX digital spatial profiling) with in silico cell type deconvolution and pathway analyses were employed on longitudinal biopsy samples from five patients across pre-treatment, on-treatment, and relapse.

Results: Of 43 participants exhibiting initial response to LIUD, 41 had follow-up data. Sixteen …

Assessing Mechanical Agency During Apical Apoptotic Cell Extrusion, Sommer Anjum, Llaran Turner, Youmna Atieh, George T Eisenhoffer, Lance A Davidson

Faculty, Staff and Student Publications

Homeostasis is necessary for epithelia to maintain barrier function and prevent the accumulation of defective cells. Unfit, excess, and dying cells in the larval zebrafish tail fin epidermis are removed via controlled cell death and extrusion. Extrusion coincides with oscillations of cell area, both in the extruding cell and its neighbors. Here, we develop a biophysical model of this process to explore the role of autonomous and non-autonomous mechanics. We vary biophysical properties and oscillatory behaviors of extruding cells and their neighbors along with tissue-wide cell density and viscosity. We find that cell autonomous processes are major contributors to the …

Epigenome Reprogramming Through H3k27 And H3k4 Trimethylation As A Resistance Mechanism To Dna Methylation Inhibition In Brafv600e-Mutated Colorectal Cancer, Hey Min Lee, Ajay Kumar Saw, Van K Morris, Stefania Napolitano, Christopher Bristow, Sanjana Srinivasan, Micheal Peoples, Alexey Sorokin, Preeti Kanikarla Marie, Jonathan Schulz, Anand K Singh, Christopher Terranova, Oluwadara Coker, Abhinav Jain, Scott Kopetz, Kunal Rai

Faculty, Staff and Student Publications

Purpose: BRAFV600E-mutated colorectal cancer exhibits a strong correlation with DNA hypermethylation, suggesting that this subgroup of tumors presents unique epigenomic phenotypes. Nonetheless, 5-azacitidine, which inhibits DNA methyltransferase activity, is not efficacious in BRAFV600E colorectal cancer in vivo.

Experimental design: We randomized and treated mice implanted with patient-derived tumor xenografts harboring BRAFV600E mutation with control, 5-azacitidine, vemurafenib (BRAF inhibitor), or the combination. Comprehensive epigenomic profiling was conducted on control and 5-azacitidine-treated tumor samples, including DNA methylation, histone modifications, chromatin accessibility, and gene expression. Combinations of epigenetic agents were explored in preclinical BRAFV600E colorectal cancer models.

Results: A profound reduction of DNA …

Sga 56 Senate 2024-11-15 Minutes, Niu Student Government Association Senate

Student Government Association Archives

No abstract provided.

Sga 56 Senate 2024-11-15 Agenda, Niu Student Government Association Senate

Student Government Association Archives

No abstract provided.

Surely You Can’T Be Serious: A Student’S Guide For Flight School Closure, Aidan Mcglasson, Sarah Nilsson

Publications

Flying aircraft, whether at a general aviation, commercial, or military level, is deeply engrained in American culture. Opinion polls place being a professional pilot as one of the most respected, and prestigious jobs in the country (Mushtaque, 2023). As evidenced by the popularity of movies such as Airplane!, Top Gun, or Sully, flying is something that fascinates many people. Perhaps contributing to its mystique is the difficulty and expense in obtaining the necessary training and certifications to be a pilot. Some people undergo flight training with the goal of flying commercially, as an airline or corporate pilot, while others do …

2024 November 15 - Tennessee Weekly Drought Summary, Tennessee Climate Office, East Tennessee State University

Tennessee Climate Office Weekly Drought Summaries

No abstract provided.

Optimization Processes Of Clinical Chelation-Based Radiopharmaceuticals For Pathway-Directed Targeted Radionuclide Therapy In Oncology, Katsumi Tomiyoshi, Lydia J. Wilson, Firas Mourtada, Jennifer Sims Mourtada, Yuta Namiki, Wataru Kamata, David J. Yang, Tomio Inoue

Department of Radiation Oncology Faculty Papers

Targeted radionuclide therapy (TRT) for internal pathway-directed treatment is a game changer for precision medicine. TRT improves tumor control while minimizing damage to healthy tissue and extends the survival for patients with cancer. The application of theranostic-paired TRT along with cellular phenotype and genotype correlative analysis has the potential for malignant disease management. Chelation chemistry is essential for the development of theranostic-paired radiopharmaceuticals for TRT. Among image-guided TRT,

Improving Employee Retention In The Virtual Workforce, Marissa Williams

Walden Dissertations and Doctoral Studies

The need for addressing employee retention in the virtual workforce is critical, particularly in the context of the U.S. General Services Administration (GSA) Region 4. High employee turnover rates can lead to significant disruptions and decreased organizational performance. This administrative case study involved identifying effective strategies to improve retention and engagement among virtual employees. The practice-focused question involved understanding key factors that influenced employee retention and developing actionable recommendations for the GSA. Insights can be applied across similar organizations facing virtual workforce challenges. Data were collected through in-depth surveys with employees that were hired between 2020 and 2023, focusing on …

Nurse Leader Education Program On Bedside Shift Report, Sharon Rae Dudley

Walden Dissertations and Doctoral Studies

The implementation and sustainability of evidence-based practices (EBP) in the nursing workflow are essential for the continual improvement of care. Though bedside shift report (BSR) was initially introduced in three hospitals in southeast Texas in 2019 and has been reimplemented three times since, BSR remains an inconsistent practice. BSR has been shown to improve patient satisfaction and patient outcomes and increase nurse engagement. The purpose of this Doctor of Nursing Practice (DNP) project was to provide interactive education for nurse leaders on the importance of BSR and the critical nature of their role in overseeing and sustaining this practice. The …

Administrators’ Perception Of Successful Implementation Of Read To Succeed In Title I Schools, Angela Sandifer Flowers

Walden Dissertations and Doctoral Studies

South Carolina implemented its Read to Succeed (RTS) policy in 2014 in accordance with federal requirements. The problem addressed in this study was that there are many students in South Carolina Title I schools still failing to achieve reading proficiency after 3 years of full implementation of RTS. The purpose of this qualitative study was to explore the perceptions of administrators from successful Title I elementary schools on their roles in the change process needed for implementing RTS. The conceptual framework was Fullan’s change theory. For this basic qualitative design, data were collected from semistructured interviews with seven participants who …

Administrators’ Perception Of Successful Implementation Of Read To Succeed In Title I Schools, Angela Sandifer Flowers

Walden Dissertations and Doctoral Studies

South Carolina implemented its Read to Succeed (RTS) policy in 2014 in accordance with federal requirements. The problem addressed in this study was that there are many students in South Carolina Title I schools still failing to achieve reading proficiency after 3 years of full implementation of RTS. The purpose of this qualitative study was to explore the perceptions of administrators from successful Title I elementary schools on their roles in the change process needed for implementing RTS. The conceptual framework was Fullan’s change theory. For this basic qualitative design, data were collected from semistructured interviews with seven participants who …

Staff Council Agenda, Georgia Southern University

Staff Council Meeting Minutes & Agendas

No abstract provided.

Impact Of The Energy Crisis On Indoor Temperatures And Thermal Comfort In Uk Houses During Winter 2023, Omar Al-Hafith, B. K. Satish, Pieter De Wilde

School of Art, Design and Architecture

Geopolitical, health and economic events have led to an accumulated surge in energy prices in the UK at the beginning of the 2020s. In response, studies and media reports show that households have had to reduce the running of their heating systems to cut their energy bills. However, there is limited research on the impact of this context on indoor thermal conditions and occupants’ ability to meet their thermal comfort needs. This study aimed to address this research gap. It employed the mixed-method research methodology and used nine homes in Plymouth as case studies. Undertaken research work involved monitoring indoor …