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Faculty Senate Minutes, Georgia Southern University, Faculty Senate

Faculty Senate Minutes

No abstract provided.

Genetic Risk Stratification And Outcomes Among Treatment-Naive Patients With Aml Treated With Venetoclax And Azacitidine, Hartmut Döhner, Keith W Pratz, Courtney D Dinardo, Andrew H Wei, Brian A Jonas, Vinod A Pullarkat, Michael J Thirman, Christian Récher, Andre C Schuh, Sunil Babu, Xiaotong Li, Grace Ku, Zihuan Liu, Yan Sun, Jalaja Potluri, Monique Dail, Brenda Chyla, Daniel A Pollyea

Faculty, Staff and Student Publications

The European LeukemiaNet (ELN) acute myeloid leukemia (AML) genetic risk classification systems are based on response to intensive chemotherapy; their ability to discriminate outcomes in older patients treated with venetoclax-azacitidine may be suboptimal. This pooled analysis of the phase 3 VIALE-A trial (NCT02993523) and phase 1b study (NCT02203773) examined prognostic stratification according to the 2017 and 2022 ELN risk classifications and derived new molecular signatures differentiating venetoclax-azacitidine-treated patients based on overall survival (OS). Overall, 279 patients treated with venetoclax-azacitidine and 113 patients treated with placebo-azacitidine were analyzed. The ELN 2017 or 2022 prognostic criteria classified most …

Birth Privilege As White Privilege, Jennifer Scuro Phd

Philosophy: Faculty Publications

In The Pregnancy ≠ Childbearing Project: A Phenomenology of Miscarriage (2017), I argued the need to ‘disentangle the plot’ of pregnancy as it has a naturalised and uncritical access to heteronormative gender privilege. In this paper, with the premise that, ‘whiteness is property,’ as argued by Cheryl Harris in 1993, I extend this work to how birthing is only a story for the white entitled few, and as an entitlement, is tied to the making and preserving of the ‘nuclear family’ and ‘family values.’ As this history of birth privilege as white privilege is also a trauma history, I include …

Qualitative Assessment Of Proposed Visual Key Information Pages For Informed Consent, Krista E. Cooksey, Eliana Goldstein, Clara Lee, Jessica Mozersky, Kimberly A. Kaphingst, Victor Catalan Gallegos, Mary C. Politi

2020-Current year OA Pubs

No abstract provided.

Determining The Role Of The Histone Demethylase Kdm5b In Microglial Reactivity To Ethanol, Jessica Wohlfahrt

USF Tampa Graduate Theses and Dissertations

Through their involvement in various processes such as phagocytosis of foreign materials and damaged cellular debris, regulatory factor release, and surveillance, the macrophages of the brain, microglia, maintain homeostasis within the central nervous system. These diverse microglial functions therefore require transition to a range of phenotypic states. The epigenetic regulation of this activity, especially through trimethylation of lysine 4 on histone H3, and its regulator, lysine demethylase (KDM)5B, is an emerging research area. KDM5B has been implicated in several diseases including cancer, inflammatory disorders, and alcohol use disorder (AUD), the latter being the focus of this dissertation project. Deep proteomic …

Teen Dating Violence And The Covid-19 Pandemic: Trends From A Longitudinal Study In Texas, Leila Wood, Elizabeth Baumler, Morgan E Pettyjohn, Jeff R Temple

Faculty, Staff and Student Publications

Purpose: Teen dating violence (TDV) is a global public health and safety issue causing health impacts to youth people. This study aimed to examine: (1) the impact of the pandemic on TDV victimisation rates and (2) socioecological factors associated with sustained risk for TDV victimisation during the first year of COVID-19.

Methods: Data are from an ongoing randomised controlled trial of a TDV prevention programme in Texas (n=2768). We conducted annual assessments in 2019-2021. We used regression modelling to assess demographic, individual, peer and family factors associated with TDV risks.

Results: TDV rates declined from 11.9% in 2019 to 5.2% …

November 21, 2024, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Talking Back As An Act Of Resistance And Healing For Black Women Survivors Of Prostitution, Amelia Cole

Electronic Theses and Dissertations Archive

The sexual abuse and prostitution of Black women is a system of oppression that has its foundation in slavery and is still embedded in the culture of the U.S. This ongoing practice of domination, racism, sexism, and class exploitation is at work daily in the lives of Black women. Some of the harsh conditions of today that limit choice and influence Black women into prostitution include poverty, lack of opportunity/education, and prior sexual, emotional, and physical abuse, which leads to a disproportionate number of women of color and girls of color who are trapped by racism and structural oppression into …

On The Total Perimeter Of Pairwise Disjoint Convex Bodies, Arseniy Akopyan, Alexey Glazyrin

School of Mathematical & Statistical Sciences Faculty Publications

In this note we introduce a pseudometric on closed convex planar curves based on distances between normal lines and show its basic properties. Then we use this pseudometric to give a shorter proof of the theorem by Pinchasi that the sum of perimeters of 𝑘 convex planar bodies with disjoint interiors contained in a convex body of perimeter 𝑝 and diameter 𝑑 is not greater than 𝑝 + 2(𝑘 − 1)𝑑.

Synthesis And Characterization Of Titanium And Vanadium Nitride–Carbon Composites, Helia Magali Morales, David A. Sanchez, Elizabeth M. Fletes, Michael Odlyzko, Victoria Padilla, Mataz Alcoutlabi, Jason Parsons

Mechanical Engineering Faculty Publications

Titanium nitride and vanadium nitride–carbon-based composite systems, TiN/C and VN/C, were prepared using a new synthesis method based on the thermal decomposition of titanyl tetraphenyl porphyrin (TiOTPP) and vanadyl tetraphenyl porphyrin (VOTPP), respectively. The structure of the TiN/C and VN/C composite materials, as well as their precursors, were characterized using Fourier Transformed Infrared Spectroscopy, X-Ray diffraction (XRD), X-Ray energy dispersive (EDS) and X-Ray photoelectron spectroscopy (XPS). Morphologies of the TiN/C and VN/C composites were examined by means of scanning electron (SEM) and transmission electron (TEM) microscopy. The synthesis of the non-metalated tetraphenyl porphyrin, the titanium, and vanadium tetraphenyl porphyrin complexes …

Understanding The Teen Brain And Building Strong Relationships: A Foundation For Supporting Healthy Decisions, Josie Hatch, Ashley Yaugher, Christina Pay, Cris Meier

All Current Publications

This fact sheet overviews the importance of strong caregiver relationships with youth to support healthy decision-making.

A Cyber Security Look At The Imo Mass Regulations, Kimberly Tam

School of Engineering, Computing and Mathematics

The International Maritime Organisation (IMO) held its second session on Maritime Autonomous Surface Ships (MASS) in April 2023. This chapter looks at the outputs of that discussion and discusses the potential cyber-physical implications and directions based on this most recent session. This cyber security lens will cover a wide range of topics such as cyber physical security, where cyber security can have a physical effect on operations and safety, as well as socio-technical cyber attacks and risks such as misinformation. This chapter will also have a wide lens in terms by looking at a wide threat landscape in the Maritime …

Strategic Interventions In Clinical Randomized Trials For Metabolic Dysfunction-Associated Steatotic Liver Disease (Masld) And Obesity In The Pediatric Population: A Systematic Review With Meta-Analysis And Bibliometric Analysis, Isabel Omaña-Guzmán, Anthony Alanis, David Martinez, Joshua Membreno, Hector Rivera-Marrero, Alisha Valdez, Kathleen V. Carter, Beatriz Tapia, Leonel Vela, Juan Lopez-Alvarenga

School of Medicine Publications

Background

Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is a prevalent hepatic condition linked to metabolic alterations. It gradually causes liver damage and potentially progresses to cirrhosis. Despite its significance, research, especially in the pediatric population, is limited, leading to contradictory findings in diagnosis and treatment. This meta-analysis aims to synthesize existing literature on therapeutic interventions for MASLD in children and adolescents.

Methods

A comprehensive search of randomized controlled clinical trials yielded 634 entries from PubMed, Scopus, and Web of Science up to 2023. Interventions included medications, behavioral modifications, dietary changes, probiotics, supplements, …

1616 President St. Assoc., Llc V Brathwaite

All Decisions

The landlord sought arrears for a rent-stabilized unit, but the tenant successfully asserted a rent-impairing violation defense under MDL § 302-a. The court found the landlord barred from collecting rent for June 2020–May 2022 due to an uncorrected HPD violation, granting a 100% rent abatement and dismissing the petition. The tenant was awarded the deposited funds, and counterclaims remain for further proceedings.

143 E 59 St Llc V. Eubanks

All Decisions

The landlord's holdover case was dismissed due to noncompliance with RPAPL 735 and 733. The court ruled that filing proof of service four days late violated RPAPL 735(2), and service completion six days before the hearing violated RPAPL 733(1)'s timing requirement. The court emphasized the importance of notice requirements for due process, denying the landlord's cross-motion and dismissing the case without prejudice.

2024-11-21 Fall Fep Reviews, Morehead State University. Faculty Senate., Evaluation Committee.

Faculty Senate Records

Evaluation Committee FEP reviews report submitted to the Faculty Senate on November 21, 2024.

2024-11-21 Pg-15 Revision Draft, Morehead State University. Faculty Senate.

Faculty Senate Records

Revision draft of PG-15 as submitted to the Faculty Senate on November 21, 2024.

2024-11-21 Faculty Senate Meeting Minutes, Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate meeting minutes from November 21, 2024.

2024-11-21 Faculty Senate Newsletter, Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate newsletter from November 21, 2024.

Multi-Institutional Report Of Trastuzumab Deruxtecan And Stereotactic Radiosurgery For Her2 Positive And Her2-Low Breast Cancer Brain Metastases, Sreenija Yarlagadda, Reshma Mahtani, Manmeet Ahluwalia, Rupesh Kotecha

All Publications

Trastuzumab-deruxtecan (T-DXd) has demonstrated intracranial efficacy; however, safety and efficacy data remains limited with stereotactic radiosurgery (SRS). A multi-institutional review was performed with HER2+ or HER2-low metastatic breast cancer treated with T-DXd and SRS for active brain metastases. We identified 215 lesions treated over 48 SRS courses in 34 patients. Median follow up from T-DXd initiation was 13.9 months. The cumulative incidence of symptomatic radiation necrosis at 24 months per lesion was 2.1% and per patient 11%. The 12-month LC was 97%. HER2-low was associated with worse distant intracranial control (DIC) (adjusted HR 2.5, 95% CI 1.1-5.6, p = 0.03) …

Plasmodium Berghei Liver Stage Parasites Exploit Host Gabarap Proteins For Tfeb Activation, Jacqueline Schmuckli-Maurer, Annina F Bindschedler, Rahel Wacker, Oliver M Würgler, Ruth Rehmann, Timothy Lehmberg, Leon O Murphy, Thanh N Nguyen, Michael Lazarou, Jlenia Monfregola, Andrea Ballabio, Volker T Heussler

Duncan NRI Faculty and Staff Publications

Plasmodium, the causative agent of malaria, infects hepatocytes prior to establishing a symptomatic blood stage infection. During this liver stage development, parasites reside in a parasitophorous vacuole (PV), whose membrane acts as the critical interface between the parasite and the host cell. It is well-established that host cell autophagy-related processes significantly impact the development of Plasmodium liver stages. Expression of genes related to autophagy and lysosomal biogenesis is orchestrated by transcription factor EB (TFEB). In this study, we explored the activation of host cell TFEB in Plasmodium berghei-infected cells during the liver stage of the parasite. Our results …

Comparison Of The Bristol Stool Scale And Modified Version For Children: Use By Providers Vs Children, James Orozco, Mariella M Self, Sara Grisales, Bruno P Chumpitazi, Danita I Czyzewski, Meagan S Mcmullen, Rebecca Berger, Clarissa A Gonzalez, Amber L Cunha, Robert J Shulman

Faculty, Staff and Students Publications

Introduction: Accurate report of stool form is essential to diagnosis and assessment of treatment response. The modified Bristol Stool Form Scale for Children (mBSFS-C) classifies stool form into 5 types and is reliable and valid. However, a direct comparison of provider's and children's ratings using the mBSFS-C vs the traditional BSFS that uses 7 stool form types has not been done.

Methods: Pediatric gastroenterology providers and children rated the same 35 stool photographs, reflecting diverse stool forms, using both scales. The order of photograph presentation and scale use were randomized. For each photograph, the most common rating (modal rating) was …

Development And Initial Validation Of The In-The-Moment Asynchronous Student Engagement Questionnaire (Itmaseq) In Higher Education, Elif Topsakal

USF Tampa Graduate Theses and Dissertations

This dissertation focuses on the development and initial validation of the In-The-Moment Asynchronous Student Engagement Questionnaire (ITMASEQ), designed to measure undergraduate student engagement—emotional, cognitive, and behavioral—in asynchronous online learning environments. The study responds to the growing need for dynamic, in-the-moment assessments of student engagement, a construct critical to understanding academic success and retention, particularly in online education.

The ITMASEQ included a total of 25 questions: Five contextual questions (study day, study place, company during the study, primary online activity, type of primary online activity), eight emotional engagement questions (enjoyment, feeling calm, anxious, focused, distracted, etc.), seven cognitive engagement questions (interest, …

Flexible Docking Method Development For Computer-Aided Drug Design, Luke C. Warrensford

USF Tampa Graduate Theses and Dissertations

Modern drug discovery, the process of identifying or developing novel therapeutic compounds to treat a disease, increasingly relies on computational methods to make the process faster and more efficient. One of the most useful tools in the computer-aided drug design toolbox is molecular docking, the simulation of a protein-ligand complex to determine ligand binding affinity. The results from molecular docking help inform the overall drug discovery process on which compounds have more potential to be potent inhibitors, thus saving time and resources during the later and more expensive stages of drug discovery. Two important considerations of modern docking methods are …

Genotype-Specific Effects Of Elamipretide In Patients With Primary Mitochondrial Myopathy: A Post Hoc Analysis Of The Mmpower-3 Trial, Amel Karaa, Enrico Bertini, Valerio Carelli, Bruce Cohen, Gregory M Ennes, Marni J Falk, Amy Goldstein, Gráinne Gorman, Richard Haas, Michio Hirano, Thomas Klopstock, Mary Kay Koenig, Cornelia Kornblum, Costanza Lamperti, Anna Lehman, Nicola Longo, Maria Judit Molnar, Sumit Parikh, Han Phan, Robert D S Pitceathly, Russekk Saneto, Fernando Scaglia, Serenella Servidei, Mark Tarnopolsky, Antonio Toscano, Johan L K Van Hove, John Vissing, Jerry Vockley, Jeffrey S Finman, Anthony Abbruscato, David A Brown, Alana Sullivan, James A Shiffer, Michelango Mancuso, Mmpower-3 Trial Investigators

Faculty, Staff and Students Publications

BACKGROUND: As previously published, the MMPOWER-3 clinical trial did not demonstrate a significant benefit of elamipretide treatment in a genotypically diverse population of adults with primary mitochondrial myopathy (PMM). However, the prespecified subgroup of subjects with disease-causing nuclear DNA (nDNA) pathogenic variants receiving elamipretide experienced an improvement in the six-minute walk test (6MWT), while the cohort of subjects with mitochondrial DNA (mtDNA) pathogenic variants showed no difference versus placebo. These published findings prompted additional genotype-specific post hoc analyses of the MMPOWER-3 trial. Here, we present these analyses to further investigate the findings and to seek trends and commonalities among those …

Insights Into Human Norovirus Cultivation In Human Intestinal Enteroids, Khalil Ettayebi, Gurpreet Kaur, Ketki Patil, Janam Dave, B Vijayalakshmi Ayyar, Victoria R Tenge, Frederick H Neill, Xi-Lei Zeng, Allison L Speer, Sara C Di Rienzi, Robert A Britton, Sarah E Blutt, Sue E Crawford, Sasirekha Ramani, Robert L Atmar, Mary K Estes

Faculty, Staff and Students Publications

Human noroviruses (HuNoVs) are a significant cause of epidemic and sporadic acute gastroenteritis worldwide. The lack of a reproducible culture system hindered the study of HuNoV replication and pathogenesis for almost a half-century. This barrier was overcome with our successful cultivation of multiple HuNoV strains in human intestinal enteroids (HIEs), which has significantly advanced HuNoV research. We optimized culture media conditions and generated genetically modified HIE cultures to enhance HuNoV replication in HIEs. Building upon these achievements, we now present new insights into this culture system, which involve testing different media, unique HIE lines, and additional virus strains. HuNoV infectivity …

2024-11-21 Governance Committee Report, Morehead State University. Faculty Senate., Governance Committee.

Faculty Senate Records

Governance Committee report submitted to the Faculty Senate on November 21, 2024.

Advanced Magnetic Sensing Technologies For Enhanced Biodetection And Healthcare Monitoring, Kee Young Hwang

USF Tampa Graduate Theses and Dissertations

The development of biosensing systems that leverage the unique properties of magnetic nanoparticles and the high sensitivity of magnetic sensors for detecting biomolecules and cancer cells has been an active area of research. However, challenges remain in detecting and differentiating the magnetic signals of biomarkers made from nanoparticles that have similar sizes but distinct magnetic properties. Additionally, overcoming the reduction in detection sensitivity caused by non-magnetic coatings on magnetic nanoparticles remains a key hurdle. Concurrently, there is a pressing need to develop advanced magnetic sensor technologies that can enhance existing healthcare monitoring systems and enable more precise, real-time diagnostics.This dissertation …

Framing Barbie: A Thematic Analysis Of News Media, Mckenzie Muskett

USF Tampa Graduate Theses and Dissertations

This study qualitatively examined how newspapers and digital media sources frame the 2023 movie, Barbie, and how news media can either perpetuate stereotypes or uproot them. This was done by first facilitating a thematic analysis of newspaper articles from five major U.S news outlets, New York Times, Washington Post, The Wall Street Journal, Los Angeles Times, and Chicago Tribune, and then from four major digital news outlets, Newsweek, Reuters, BBC, and NewsNation. This study utilized framing theory to identify ten frames news outlets used to frame Barbie. Additionally, feminist theory was implemented to inform the findings and analyze the articles. …

Auction-Based Tolling Systems: Addressing Behavioral Economics And Social Equity Concerns, Tung Huy Vo

USF Tampa Graduate Theses and Dissertations

The value of time (VOT), or willingness to pay (WTP) to reduce travel time in the context of transportation, is not homogeneous across all road users. Everyone has their own unique VOT and may have multiple values for the VOT associated with factors such as the time of day or the trip purpose. However, the traditional distance-based, time-based, or demand-based congestion pricing methods cannot reflect the true WTP for the use of tolled facilities of the road users. Recent studies have explored and proposed an innovative congestion pricing scheme that integrates auction mechanisms into tolling systems, known as auction-based tolling …