Digital Commons Network^™

The Akwesasne Black Hole: America’S Hidden Border Crisis, Anthony Puntasecca

University of Miami Inter-American Law Review

No abstract provided.

Clinical Effects Of Dexamethasone Among Patients With Sickle Cell Disease Hospitalized With Covid-19: Outcomes From A Single Academic Health System, William M. Garneau, Matthew J. Lankiewicz, Catherine R. Lesko, Ashley P. Lauriello, Kelly A. Gebo, Sophie M. Lanzkron

Department of Medicine Faculty Papers

BACKGROUND: Dexamethasone is a steroid used in the treatment of hospitalized patients with severe COVID-19. However, the effect of dexamethasone in patients with SCD remains unclear given that steroids may precipitate vaso-occlusive crisis (VOC) in patients with SCD.

METHODS AND FINDINGS: We performed a retrospective analysis of patients with SCD who were hospitalized at Johns Hopkins Health System between June 1, 2020 and June 26, 2022. We reviewed individual charts to assess severity of illness and eligibility for dexamethasone treatment. The exposure of interest was treatment with dexamethasone. Outcomes of interest included incident VTE, length of hospital stay, ICU admission, …

November 26, 2024 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Casey Gill Named Vice President For Student Development And Chief Student Experience Officer, University Of Dayton

News Releases

Casey Gill, vice president for student development and dean of students at Wittenberg University, will become vice president for student development and chief student experience officer at the University of Dayton Jan. 1.

Bismuth And Tellurium Co-Doping: A Route To Improve Thermoelectric Efficiency In Inse Polycrystals, Manasa R. Shankar, A. N. Prabhu, Tulika Srivastava

Open Access archive

Indium selenide (InSe), a layered chalcogenide material, has gained substantial scientific interest as a thermoelectric material due to its intrinsic low thermal conductivity. However, its intrinsic carrier concentration is notably minimal (∼10¹⁴ cm⁻³) due to a significant bandgap of 1.3 eV limiting its thermoelectric efficiency. Therefore, to optimize InSe-based materials for thermoelectric applications, it is essential to increase the carrier concentration through precise doping methodologies. In this study, co-doping at both the anion and cation sites of InSe was achieved by introducing Bi to the In site and Te to the Se site. The impact of this …

Colonising Creatitvity_Combined Final Script 2024_Published, Strutts Psyridis Med, James Thompson Phd

Staff Scholarship - Australia & Dubai

This paper examines the evolving landscape of contemporary screen education, with a focus on the impact of progressive, constructivist and vocational pedagogies, arguing that their convergence with digital surveillance and AI risks undermining student agency and creative ownership. The authors draw on philosophical and educational perspectives to contrast and critique artistic, scientific, and vocational models of creativity and highlight the twenty-first century shift to technocratic imperatives within these pedagogies. The paper contends that techno-centric, market-driven learning environments may counter stated student-centred aims, and colonise students’ creative consciousness. The authors conclude by advocating for renewed emphasis on embodied, experiential practice in …

Effect Of Patient Resilience On Functional Outcomes After Meniscectomy, Adeeb Hanna, Andres Perez, Alice He, John Sonnier, Henson Destine, Rahul Muchintala, Ralph Cook, Sean Bryan, Fotios Tjoumakaris, Kevin Freedman

Rothman Institute Papers

BACKGROUND: Recent literature has identified that patient resilience may affect outcomes after meniscectomy. Research into psychological risk factors for poor surgical outcomes has been a focus in orthopaedic surgery.

PURPOSE/HYPOTHESIS: The purpose of this study was to examine the relationship between preoperative patient resilience and 2-year postoperative outcomes after arthroscopic meniscectomy. It was hypothesized that there would be no relationship between resilience and patient-reported outcomes after meniscectomy.

STUDY DESIGN: Cohort study; Level of evidence, 2.

METHODS: Patients who underwent meniscectomy between January and June 2020 at a single multicenter institution were identified, and those aged ≥18 years without evidence of …

Identifying Redundant Audio Content Over Cloud Environment Using Deduplication Techniques, Venkatesh K

Theses and Dissertations

Cloud computing has become an integral part of modern internet-based services, with users relying heavily on cloud environments as primary storage solutions. However, the exponential growth in data volume presents a challenge (i.e) the proliferation of duplicated content within cloud repositories. Deduplication techniques provide a promising approach to mitigate this issue. This research focuses on detecting redundant audio content within a cloud environment, specifically targeting the sharing of extensive audio files, such as those in Waveform Audio File Format (WAV). The study proposes the Refined Super Subset Identification Algorithm (RSSIA) to efficiently identify redundant content and segments within existing audio …

Enhancing Immune Response And Survival In Hepatocellular Carcinoma With Novel Oncolytic Jurona Virus And Immune Checkpoint Blockade, Mulu Z. Tesfay, Yuguo Zhang, Khandoker U. Ferdous, Mika A. Taylor, Aleksandra Cios, Randal S. Shelton, Camila C. Simoes, Chelsae R. Watters, Oumar Barro, Natalie M. Elliott, Bahaa Mustafa, Jean Christopher Chamcheu, Alicia L. Graham, Charity L. Washam, Duah Alkam, Allen Gies, Stephanie D. Byrum, Emmanouil Giorgakis, Steven R. Post, Thomas Kelly, Jun Ying, Omeed Moaven, Chiswili Y. Chabu, Martin E. Fernandez-Zapico, Dan G. Duda, Lewis R. Roberts, Rang Govindarajan, Mitesh J. Borad, Martin J. Cannon, Et Al

School of Medicine Faculty Publications

Members of the Vesiculovirus genus including Jurona virus (JURV) have emerged as promising immunotherapeutic agents, characterized by their tumor selectivity, fast kinetics, low seroprevalence, and minimal toxicity in humans. Here, we demonstrate that the administration of JURV leads to tumor regression in both hepatocellular carcinoma (HCC) xenograft and syngeneic models. Furthermore, our findings indicate that combining JURV and anti-PD-1 therapy reduced tumor burden and improved survival rates over JURV or anti-PD-1 alone in an orthotopic HCC model. Proteogenomic analysis of JURV-treated, murine HCC tumors demonstrates that the therapeutic effects of the combination of JURV and anti-PD-1 are predominantly driven by …

Cardiac Amyloidosis Versus Other Restrictive Cardiomyopathies: A Retrospective Analysis Of Cardiovascular Outcomes And Arrhythmic Burden, Andrew Sagalov, Waqas Ullah, Yevgeniy Brailovsky, Michael Buhnerkempe, Steve Scaife, Abhishek Kulkarni, Mohamed Labedi, Shruti Hegde

Abington Jefferson Health Papers

BACKGROUND: The arrhythmic burden and cardiovascular risks of cardiac amyloidosis compared with other types of restrictive cardiomyopathies (RCM), such as hemochromatosis and cardiac sarcoid, have not been well characterized in the literature. An increase in emphasis on screening has resulted in more diagnoses of cardiac amyloidosis and a larger data pool to analyze the cardiovascular outcomes of this cardiomyopathy.

METHODS AND RESULTS: We queried the National Inpatient Sample (NIS) database to identify all adult patients diagnosed with cardiac amyloidosis or other RCM between the years 2016 and 2019. Discharge-weighted analysis using survey regressions accounts for discharge weights and characteristics found …

Enhancing Immune Response And Survival In Hepatocellular Carcinoma With Novel Oncolytic Jurona Virus And Immune Checkpoint Blockade, Mulu Z. Tesfay, Yuguo Zhang, Khandoker U. Ferdous, Mika A. Taylor, Aleksandra Cios, Randal S. Shelton, Camila C. Simoes, Chelsae R. Watters, Oumar Barro, Natalie M. Elliott, Bahaa Mustafa, Jean Christopher Chamcheu, Alicia L. Graham, Charity L. Washam, Duah Alkam, Allen Gies, Stephanie D. Byrum, Emmanouil Giorgakis, Steven R. Post, Thomas Kelly, Jun Ying, Omeed Moaven, Chiswili Y. Chabu, Martin E. Fernandez-Zapico, Dan G. Duda, Lewis R. Roberts, Rang Govindarajan, Mitesh J. Borad, Martin J. Cannon, Et Al

School of Graduate Studies Faculty Publications

Members of the Vesiculovirus genus including Jurona virus (JURV) have emerged as promising immunotherapeutic agents, characterized by their tumor selectivity, fast kinetics, low seroprevalence, and minimal toxicity in humans. Here, we demonstrate that the administration of JURV leads to tumor regression in both hepatocellular carcinoma (HCC) xenograft and syngeneic models. Furthermore, our findings indicate that combining JURV and anti-PD-1 therapy reduced tumor burden and improved survival rates over JURV or anti-PD-1 alone in an orthotopic HCC model. Proteogenomic analysis of JURV-treated, murine HCC tumors demonstrates that the therapeutic effects of the combination of JURV and anti-PD-1 are predominantly driven by …

Front Matter Volume 14, Issue 1

Tennessee Journal of Race, Gender, & Social Justice

No abstract provided.

Reparations And Higher Education: How Public Universities May Offer Reparation Scholarships To Black Students In The Post-Affirmative Action Era After Students For Fair Admissions V. Harvard, William Y. Chin

Tennessee Journal of Race, Gender, & Social Justice

No abstract provided.

Friends With Social Benefits: Queerplatonic Relationships And The Future Of Marriage

Tennessee Journal of Race, Gender, & Social Justice

No abstract provided.

The Dying Art Of Dining Together: What Has Happened To Mealtimes?, Erin Olson

Faculty Work Comprehensive List

"we... need to work to protect these precious and valuable times with our families around the table."

Posting about ­­­­­­­­prioritizing our relationships by eating together from In All Things, an online hub that offers insight into maintaining and faithful and orthodox Reformed Christian worldview while fearlessly engaging in every aspect of contemporary life – until all is made new.

The Dying Art of Dining Together

Animal Science News (November 26, 2024), Department Of Animal Science

Animal Science Newsletters

No abstract provided.

Placing The Four Rounds Of Israeli-Palestinian Negotiations In The Twenty-First Century In A Historical And Philosophical Context, Michael J. Reimer Dr

Department of Political Science and Law Faculty Scholarship and Creative Works

This paper will take a three-pronged approach to the analysis of prior treaty negotiations and their comparison to the Israeli Palestinian conflict. The first prong, which will be addressed in the next section, will be a historical analysis of other treaty negotiations which resulted in end of conflict treaties. These examinations will include The Congress of Vienna, 1814-1815; the Portsmouth Treaty, 1905 which involved a Treaty between a European and a non-European state2 negotiated by the President of the United States and American Diplomats; the Paris Peace Conferences of 19193 ; and Multiparty Mediation in Cyprus, 1963-1965. In each of …

Aircraft Control, Collision Avoidance, And Remote Autonomy In Scenarios With Ground Radar Information, Jaron Charles Ellingson

Theses and Dissertations

Unmanned aircraft systems (UAS) have become integral to various modern applications, including package delivery, security, medicine, and recreation. The autonomous operation of UAS significantly enhances their utility by improving performance and reducing operator workload, enabling collaborative missions such as boundary detection, border protection, and target tracking. To ensure safe integration of UAS, more work needs to be done in the areas of control, estimation, collision avoidance, path planning, hardware implementation, and autonomous practices in general. For this dissertation we chose to focus on the critical areas of control, collision avoidance, and remote autonomy. Our research is motivated by the need …

The Effectiveness Of Ultrasound-Indicated Cerclage For The Reduction Of Extreme Preterm Birth In Twin Pregnancies With A Short Cervix: A Systematic Review And Meta-Analysis, Lissa Van Gils, Renske Dutilh, Nerissa Denswil, Amanda Roman, Marjon A De Boer, Eva Pajkrt, Martijn A Oudijk

Department of Obstetrics and Gynecology Faculty Papers

OBJECTIVE: This study aimed to evaluate the effectiveness of cervical cerclage in women with a twin pregnancy and a midpregnancy asymptomatic short cervix (≤25 mm), in preventing preterm birth and improving neonatal outcomes.

DATA SOURCES: Systematic searches were conducted in MEDLINE, Embase, Web of Science, Scopus, and Cochrane Library up to April 17, 2023, updated in September and February 2024.

STUDY ELIGIBILITY CRITERIA: Included were randomized controlled trials, cohort studies, and case-control studies comparing cerclage with expectant management in twin pregnancies and an asymptomatic short cervix (≤25 mm).

METHODS: Risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale …

Multiple Factors Regulate The Expression Of Sufcdsub In Streptococcus Mutans, Kassapa Ellepola, Lauren C. Guillot, Bradley Comeaux, Yiran Han, Jessica K. Kajfasz, Jacob P. Bitoun, Grace Spatafora, Jose A. Lemos, Zezhang T. Wen

School of Dentistry Faculty Publications

Introduction: The sufCDSUB gene cluster, encoding the sole iron-sulfur (Fe-S) cluster assembly system in S. mutans, was recently shown to be up-regulated in response to oxidative stressors and Fe limitation. Methods: In this study, luciferase reporter fusion assays, electrophoretic gel mobility shift assays (EMSA) and in vitro transcription assays (IVT) were used to dissect the cis- and trans-acting factors that regulate the expression of sufCDSUB. Results and discussion: Results showed deletion of perR, for the only Fur-family transcriptional regulator in S. mutans, resulted in > 5-fold increases in luciferase activity under the control of the sufCDSUB promoter (P < 0.01), as compared to the parent strain, UA159 when the reporter strains were grown in medium with no supplemental iron. Site-directed mutagenesis of a PerR-box in the promoter region led to elevation of the reporter activity by >1.6-fold (P < 0.01). In an EMSA, recombinant PerR (rPerR) was shown to bind to the cognate sufCDSUB promoter leading to mobility retardation. On the other hand, the reporter activity was increased by > 84-fold …

Evaluating An Evidence-Based Quality Improvement Initiative For Food Insecurity Screening And Referral In Adults With Diabetes Initiating Continuous Glucose Monitor Therapy, Coni Dennis

Graduate Theses, Dissertations, and Capstones

Diabetes affects 37 million people annually in the United States, with direct medical costs exceeding $237 billion per year (American Diabetes Association, 2018; Xu et al., 2018). Complications account for up to 64% of diabetes-related expenses, emphasizing the importance of glycemic stability in preventing costly and debilitating outcomes (Dieleman et al., 2016). Diet and nutrition, essential for glycemic control, are often undermined by food insecurity—defined as inconsistent access to adequate, nutritious food—affecting 16% of adults with diabetes (Casagrande et al., 2022; Kirby et al., 2021). Food insecurity is linked to higher HbA1c levels, increased complications, and hospitalizations (Thomas et al., …

Intelligent Transportation System With 5g Vehicle-To-Everything (V2x): Architectures, Vehicular Use Cases, Emergency Vehicles, Current Challenges, And Future Directions, Vaishali Pawar, Nilima Zade, Deepali Vora, Vaishali Khairnar, Aurenice M. Oliveira, Ketan Kotecha, Ambarish Kulkarni

Michigan Tech Publications

In recent years, connected vehicle technologies emerged to provide a safer and more connected environment for transportation systems, which has further evolved into cellular vehicle-to-everything (C-V2X) technology. The current study contributes in the direction of future research of smart India @2047 in connected vehicles. The study presents the diverse aspects of 5G V2X as a comprehensive overview of Vehicle-to-Everything (V2X) technology that covers the significant scope of V2X technology, including its development, components, functionality, use cases, and future potential. It is observed that few surveys are available that cover limited aspects of 5G V2X communication technologies, with one or two …

Separating A Particle's Mass From Its Momentum, Mordecai Waegell, Jeff Tollaksen, Yakir Aharonov

Mathematics, Physics, and Computer Science Faculty Articles and Research

The Quantum Cheshire Cat experiment showed that when weak measurements are performed on pre- and post-selected system, the counterintuitive result has been obtained that a neutron is measured to be in one place without its spin, and its spin is measured to be in another place without the neutron. A generalization of this effect is presented with a massive particle whose mass is measured to be in one place with no momentum, while the momentum is measured to be in another place without the mass. The new result applies to any massive particle, independent of its spin or charge. A …

Social Media As Health Educator: An Assessment Of The Understandability And Accuracy Of Tiktok Content About Contraception, Julianna Coleman, Maetal Haas-Kogan, Andrea Pelletier, Rachel Stoddard, Natasha Johnson, Julia Beatini, Nora Sun, Alex Keuroghlian, Deborah Bartz

Department of Family & Community Medicine Faculty Papers

BACKGROUND: Contraception knowledge and attitudes are largely formed from conversations within one's social network. More recently, this network has expanded to include social media. As the fastest growing social media platform, we aimed to assess popular contraception videos on TikTok for content understandability, actionability and accuracy.

METHODS: This is a secondary analysis of the most viewed, contraception-specific TikTok videos that were previously coded as containing educational messaging in a content-analysis study. We assessed videos for understandability (ability to explain a key message) and actionability (identify what they can do to act on that message) using the Patient Education Materials Assessment …

Genetic Manipulation Of Caveolin-1 In A Transgenic Mouse Model Of Aortic Root Aneurysm: Sex-Dependent Effects On Endothelial And Smooth Muscle Function, Tala Curry-Koski, Brikena Gusek, Ross M. Potter, T. B. Jones, Raechel Dickman, Nathan Johnson, John N. Stallone, Roshanak Rahimian, Johana Vallejo-Elias, Mitra Esfandiarei

Pacific Faculty Work

Marfan syndrome (MFS) is a systemic connective tissue disorder stemming from mutations in the gene encoding Fibrillin-1 (Fbn1), a key extracellular matrix glycoprotein. This condition manifests with various clinical features, the most critical of which is the formation of aortic root aneurysms. Reduced nitric oxide (NO) production due to diminished endothelial nitric oxide synthase (eNOS) activity has been linked to MFS aortic aneurysm pathology. Caveolin-1 (Cav1), a structural protein of plasma membrane caveolae, is known to inhibit eNOS activity, suggesting its involvement in MFS aneurysm progression by modulating NO levels. In this study, we examined the role of Cav1 in …

Characterising The Anxiogenic Network From Functional Connectivity Analysis Of The Co2 Challenge Model, Daniel Graham, Santra Mathew, Jonathan Marsden, Alastair D Smith, Gary Smerdon, Stephen D Hall

School of Psychology

The CO2 challenge model (CCM) is a gas inhalation paradigm that provides precisely controlled anxiety induction in experimental settings. Despite its potential as an experimental model of anxiety, our understanding of the neural effects of the CCM is incomplete. This study employs resting-state functional magnetic resonance imaging (rs-fMRI) to explore functional connectivity (FC) changes underlying the CCM. Following a preliminary CO2 tolerance assessment, participants completed an MRI session that included three rs-fMRI scans: during inhalation of control air (pre and post), and during a 6% CCM exposure. Here, we confirm that 6% CCM is a tolerable anxiogenic model in the …

Cd4+ T Cells Drive Corneal Nerve Damage But Not Epitheliopathy In An Acute Aqueous-Deficient Dry Eye Model, Alexia Vereertbrugghen, Manuela Pizzano, Agostina Cernutto, Florencia Sabbione, Irene A Keitelman, Douglas Vera Aguilar, Ariel Podhorzer, Federico Fuentes, Celia Corral-Vázquez, Mauricio Guzmán, Mirta N Giordano, Analía Trevani, Cintia S De Paiva, Jeremías G Galletti

Faculty, Staff and Students Publications

Dry eye disease (DED) is characterized by a dysfunctional tear film in which the corneal epithelium and its abundant nerves are affected by ocular desiccation and inflammation. Although adaptive immunity and specifically CD4+ T cells play a role in DED pathogenesis, the exact contribution of these cells to corneal epithelial and neural damage remains undetermined. To address this, we explored the progression of a surgical DED model in wild-type (WT) and T cell-deficient mice. We observed that adaptive immune-deficient mice developed all aspects of DED comparably to WT mice except for the absence of functional and morphological corneal nerve changes, …

An Integrative Approach Clarifies Species Delimitation And Biogeographic History Of Debregeasia (Urticaceae), Amos Kipkoech, Ke Li, Richard I. Milne, Oyetola Olesegun Oyebanji, Moses C. Wambulwa, Xiao-Gang Fu, Dennis A. Wakhungu, Zheng-Yuan Wu, Jie Liu

Biological Sciences Faculty Publications and Presentations

Integrative data from plastid and nuclear loci are increasingly utilized to resolve species boundaries and phylogenetic relationships within major angiosperm clades. Debregeasia (Urticaceae), an economically important genus, presents challenges in species delimitation due to its overlapping morphological traits and unstable taxonomic assignments. Here, we analyzed 14 morphological traits and generated 12 data matrices from the plastomes and nrDNA using genome skimming from the nine recognized morphospecies to clarify species boundaries and assess barcode performance in Debregeasia. We also used a universal set of 353 nuclear genes to explore reticulate evolution and biogeographic history of Debregeasia. Plastomes of Debregeasia …

Improving Medication Administration Times With An Lpn Primary Care Nursing Model, Jennifer Dentinger

Graduate Theses, Dissertations, and Capstones

This dissertation describes the outcomes of medication administration times after implementing a LPN primary care nursing model.

Student Comprehension Of Biochemistry In A Flipped Classroom Format, Ed Harris, Evan A. Schroder, Teryn J. Berks

Department of Biochemistry: Faculty Publications

Concept-heavy courses such as Biochemistry in life and physical science curricula are challenging for many college-aged students. It is easy for students to disengage in a lecture and not learn the subject matter while in class. To improve student learning and participation, we employed a flipped format for the first half of the course and compared learning outcomes and attitudes with the traditional lecture in the second half of the course. The experimental course was an upper-level biochemistry course taken primarily by juniors (49%), seniors (40%), and some graduate students (10%) at the college level. Our results indicate that lower-performing …