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Correction To: Oncologists’ Palliative Care Referral Behaviour: Testing Utility Of Social Exchange Theory As An Explanatory Framework (Bmc Palliative Care, (2024), 23, 1, (183), 10.1186/S12904-024-01517-0), Naveen Salins, Sean Hughes, Nancy Preston Dec 2024

Correction To: Oncologists’ Palliative Care Referral Behaviour: Testing Utility Of Social Exchange Theory As An Explanatory Framework (Bmc Palliative Care, (2024), 23, 1, (183), 10.1186/S12904-024-01517-0), Naveen Salins, Sean Hughes, Nancy Preston

Open Access archive

https://doi.org/10.1186/s12904-024-01517-0. Following publication of the original article [1], the author wants to update the Acknowledgements and Funding sections by removing the data in bold. We thank the Tata Trusts, Narotam Sekhsaria Foundation, Hamied Foundation, and Cipla Foundation for supporting this study. We also extend our thanks to faculty of Lancaster University and Kasturba Medical College, Manipal, for their invaluable assistance, both directly and indirectly, in our research. We thank the Tata Trusts and Narotam Sekhsaria Foundation for supporting this study. We also extend our thanks to faculty of Lancaster University and Kasturba Medical College, Manipal, for their invaluable assistance, both …


Conformational Plasticity Links Structural Instability Of Naa10f128i And Naa10f128l Mutants To Their Catalytic Deregulation, Smita Saha, Buddhi Prakash Jain, Debasish Kumar Ghosh, Akash Ranjan Dec 2024

Conformational Plasticity Links Structural Instability Of Naa10f128i And Naa10f128l Mutants To Their Catalytic Deregulation, Smita Saha, Buddhi Prakash Jain, Debasish Kumar Ghosh, Akash Ranjan

Open Access archive

The acetylation of proteins' N-terminal amino groups by the N-acetyltransferase complexes plays a crucial role in modulating the spatial stability and functional activities of diverse human proteins. Mutations disrupting the stability and function of NAA10 result in X-linked rare genetic disorders. In this study, we conducted a global analysis of the impact of fifteen disease-associated missense mutations in NAA10. The analyses revealed that mutations in specific residues, such as Y43, V107, V111, and F128, predictably disrupted interactions essential for NAA10 stability, while most mutations (except R79C, A111W, Q129P, and N178K) expectedly led to structural destabilization. Mutations in many conserved residues …


Exploring Peptide Dendrimers For Intestinal Lymphatic Targeting: Formulation And Evaluation Of Peptide Dendrimer Conjugated Liposomes For Enhancing The Oral Bioavailability Of Asenapine Maleate, Ajjappla Basavaraj Shreya, Abhijeet Pandey, Sanjay Kulkarni, K. Vijaya Bhaskar Dec 2024

Exploring Peptide Dendrimers For Intestinal Lymphatic Targeting: Formulation And Evaluation Of Peptide Dendrimer Conjugated Liposomes For Enhancing The Oral Bioavailability Of Asenapine Maleate, Ajjappla Basavaraj Shreya, Abhijeet Pandey, Sanjay Kulkarni, K. Vijaya Bhaskar

Open Access archive

Asenapine maleate (ASPM) is a second-generation atypical antipsychotic that is approved for treating acute schizophrenia and bipolar disorder in adults by the US FDA. The major downside of ASPM therapy is rapid, extensive first-pass hepatic metabolism following its oral administration with a very low oral bioavailability of < 2%. In this work, we developed ASPM nanoformulations conjugated with ligands such as arginine-glycine-aspartic acid (RGD) and peptide dendrimers (PDs) with the intention of improving the oral bioavailability of the drug by targeting it to the intestinal lymphatic system (ILS). Peptide dendrimers (PDs), both lipidated and nonlipidated, were synthesized by Fmoc solid phase peptide synthesis (SPPS). Reverse phase high performance chromatography (RP-HPLC) was used to purify the synthesized PDs, and the PDs were characterized by differential scanning calorimetry (DSC) electrospray ionization mass spectroscopy (ESI+-MS), Nuclear magnetic resonance (NMR) and Fourier transform infrared (FTIR) spectroscopy. The thin film hydration method was used to prepare liposomes, and the process variables affecting the liposome parameters were optimized using the Box‒Behnken design (BBD).Liposomes were PEGylated using DSPE-PEG-COOH2000 and further conjugated with ligands (RGD, PD-1 and PD-2) using EDC-NHS chemistry. …


In Vitro And In Silico Insights Into Antimicrobial And Anticancer Activities Of Novel Imidazo[2,1-B][1,3,4]Thiadiazoles, Deepika Dwarakanath, Yogeesha N. Nayak, Ananda Kulal, Samyak Pandey Dec 2024

In Vitro And In Silico Insights Into Antimicrobial And Anticancer Activities Of Novel Imidazo[2,1-B][1,3,4]Thiadiazoles, Deepika Dwarakanath, Yogeesha N. Nayak, Ananda Kulal, Samyak Pandey

Open Access archive

This study explores the design, synthesis, and evaluation of a novel series of isobenzofuran-based imidazo[2,1-b][1,3,4]thiadiazole derivatives, targeting their antimicrobial and anticancer properties. These compounds integrate the pharmacologically significant 1,3,4-thiadiazole and imidazole moieties, which are known for their potential in drug development, although imidazo[2,1-b][1,3,4]thiadiazole-based drugs are not yet available on the market. Therefore, the aim of this study is to develop novel derivatives that could serve as promising candidates for future therapeutic applications. The derivatives were synthesized in two steps and thoroughly characterized using IR, 1H NMR, 13C NMR, and mass spectrometry. All the derivatives had shown fairly good …


Analysis Of Ventricular Repolarization Parameters And Heart Rate Variability In Obesity: A Comparative Study, Akash Tomar, Himani Ahluwalia, H. S. Isser, Sameer Gulati Dec 2024

Analysis Of Ventricular Repolarization Parameters And Heart Rate Variability In Obesity: A Comparative Study, Akash Tomar, Himani Ahluwalia, H. S. Isser, Sameer Gulati

Open Access archive

Obesity is associated with dysfunctional electrocardiographic and cardiac autonomic parameters, which may lead to increased cardiovascular morbidity. Novel electrocardiographic repolarization markers such as Tpeak-Tend (Tpe) interval have not yet been deeply studied in obese patients. We aimed to investigate the association between ventricular repolarization parameters and heart rate variability (HRV) and how they are affected by changes occurring in the cardiac autonomic nervous system. Ninety subjects categorized by Southeast Asian BMI (kg/m2) standards - normal (18-22.9), overweight (23-24.9), and obese (> 24.9), underwent assessment of ventricular repolarization parameters and HRV. Linear correlation between different parameters was also conducted. …


Hybrid Optimization For Efficient 6g Iot Traffic Management And Multi-Routing Strategy, J. Logeshwaran, Shobhit K. Patel, Om Prakash Kumar, Fahah Ahmed Al-Zahrani Dec 2024

Hybrid Optimization For Efficient 6g Iot Traffic Management And Multi-Routing Strategy, J. Logeshwaran, Shobhit K. Patel, Om Prakash Kumar, Fahah Ahmed Al-Zahrani

Open Access archive

Efficient traffic management solutions in 6G communication systems face challenges as the scale of the Internet of Things (IoT) grows. This paper aims to yield an all-inclusive framework ensuring reliable air pollution monitoring throughout smart cities, capitalizing on leading-edge techniques to encourage large coverage, high-accuracy data, and scalability. Dynamic sensors deployed to mobile ad-hoc pieces of fire networking sensors adapt to ambient changes. To address this issue, we proposed the Quantum-inspired Clustering Algorithm (QCA) and Quantum Entanglement and Mobility Metric (MoM) to enhance the efficiency and stability of clustering. Improved the sustainability and durability of the network by incorporating Dynamic …


Enhancing Urban Sustainability: A Study On Lightweight And Pervious Concrete Incorporating Recycled Plastic, S. Sathvik, Pathapati Rohithkumar, Pshtiwan Shakor, Shahaji Dec 2024

Enhancing Urban Sustainability: A Study On Lightweight And Pervious Concrete Incorporating Recycled Plastic, S. Sathvik, Pathapati Rohithkumar, Pshtiwan Shakor, Shahaji

Open Access archive

Increasing of plastic waste threatening ecosystems globally, this experimental work investigates recycled plastics as sustainable aggregate replacements in pervious concrete. Pervious concrete allows water passage but has installation/maintenance difficulty due to high weight. This research addresses the lack of eco-friendly lightweight pervious solutions by assessing physical and mechanical performance of mixes with 100% recycled plastic and traditional aggregate percentages. Density reduced 12% using a 100% plastic aggregate mix, achieving 1358 kg/m3 with compressive strength of 3.92 MPa, adequate for non-structural applications. A 7.8% decrease in water absorption versus conventional pervious concrete signifies retained porosity and permeability despite the plastic …


Synthesis And Performance Evaluation Of Zno/Cds Photoanodes With Copper Sulfide (Cu2s) And Carbon Counter Electrodes, Pooja B. More, Chaitali V. Jagtap, Vishal S. Kadam, Mu Naushad Dec 2024

Synthesis And Performance Evaluation Of Zno/Cds Photoanodes With Copper Sulfide (Cu2s) And Carbon Counter Electrodes, Pooja B. More, Chaitali V. Jagtap, Vishal S. Kadam, Mu Naushad

Open Access archive

The present study demonstrates the synthesis of compact ZnO layers using CdS sensitized on ZnO as a photoanode with copper sulfide (Cu2S) and carbon as a counter electrode (CE). In this study, a compact ZnO layer was fabricated using the simple and low-cost successive ionic layer adsorption and reaction (SILAR) method, and Cu2S CE films were synthesized using the chemical bath deposition method. Various characterizations, such as X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS), confirmed the formation of ZnO and CdS sensitizations on the ZnO. UV-visible spectroscopy revealed that the bandgaps of the ZnO and Cu2S films were 3.2 …


Literature Review And Case Study: Unveiling The Complexities Of Mandibular Second Molar With Three Distal Canals, Anoushka Yadav, Anushka Arora, Karthik Shetty, Mohmed Isaqali Karobari Dec 2024

Literature Review And Case Study: Unveiling The Complexities Of Mandibular Second Molar With Three Distal Canals, Anoushka Yadav, Anushka Arora, Karthik Shetty, Mohmed Isaqali Karobari

Open Access archive

The occurrence of morphological deviations in root canal anatomy is challenging and can influence treatment outcomes. While mandibular second molars typically have 2 roots and 3 canals, a unique case emerged in a 23-year-old Indian male with a symptomatic permanent left mandibular second molar showing three distal, two mesial canals, and two roots. The tooth presented as non-mobile but tender on percussion. The patient was diagnosed with symptomatic irreversible pulpitis with symptomatic apical periodontitis. The presence of mid distal canal was radiographically and visually confirmed with the aid of limited FOV cone-beam computed tomography and the dental operating microscope. Successful …


Optical, Thermal, And Structural Properties Of Er3+ Incorporated Double Perovskite Ca2mgwo6 Phosphors, Kiran R, Princy A, S. Masilla Moses Kennedy, M. I. Sayyed Dec 2024

Optical, Thermal, And Structural Properties Of Er3+ Incorporated Double Perovskite Ca2mgwo6 Phosphors, Kiran R, Princy A, S. Masilla Moses Kennedy, M. I. Sayyed

Open Access archive

Novel Ca2MgWO6 phosphors doped with xEr3+ (x = 0.5, 1, 2, 3, and 4 mol%) were synthesized using the solid-state reaction method. Using XRD and FTIR analyses, successful product formation was confirmed. Subsequently, the phosphor was optimized by focusing on the characteristic emission peak at 529 nm, arising from the transition 2H11/2 → 4I15/2. The optimal concentration of Er³⁺ for the given host system was determined to be 2 mol%. Meticulous analyses revealed that the optimized phosphor possessed a direct optical band gap of 3.68 eV and the bonding parameter confirmed that the nature of bonding was …


Deep Squeezenet Learning Model For Diagnosis And Prediction Of Maize Leaf Diseases, Prasannavenkatesan Theerthagiri, A. Usha Ruby, J. George Chellin Chandran, Tanvir Habib Sardar Dec 2024

Deep Squeezenet Learning Model For Diagnosis And Prediction Of Maize Leaf Diseases, Prasannavenkatesan Theerthagiri, A. Usha Ruby, J. George Chellin Chandran, Tanvir Habib Sardar

Open Access archive

The maize leaf diseases create severe yield reductions and critical problems. The maize leaf disease should be discovered early, perfectly identified, and precisely diagnosed to make greater yield. This work studies three main leaf diseases: common rust, blight, and grey leaf spot. This approach involves pre-processing, including sampling and labelling, while ensuring class balance and preventing overfitting via the SMOTE algorithm. The maize leaf dataset with augmentation was used to classify these diseases using several deep-learning pre-trained networks, including VGG16, Resnet34, Resnet50, and SqueezeNet. The model was evaluated using a maize leaf dataset that included various leaf classes, mini-batch sizes, …


An Assessment Of Workability, Mechanical And Durability Properties Of High-Strength Concrete Incorporating Nano-Silica And Recycled E-Waste Materials, Pawan Hinge, Tushar Shende, Rahul Ralegaonkar, Bhupesh Nandurkar Dec 2024

An Assessment Of Workability, Mechanical And Durability Properties Of High-Strength Concrete Incorporating Nano-Silica And Recycled E-Waste Materials, Pawan Hinge, Tushar Shende, Rahul Ralegaonkar, Bhupesh Nandurkar

Open Access archive

Background: Presently, the proper disposal of E-waste is a major challenge for all nations. Portland cement and aggregates continue to play a major role in the construction industry's operations. Meanwhile, natural resources like gravel (aggregates) are becoming scarce. Thus, E-waste is now offering the building industry a chance to replace traditional aggregates. The main goal of the current study is to determine the highest amount of E-waste that may be replaced with 10-mm coarse aggregates with a nano-silica associated ternary blend in M-60 grade high-strength concrete while still maintaining the designed concrete's mechanical, durability, microstructural and workability characteristics. Results: When …


Cool-Core, X-Ray Cavities, And Cold Front Revealed In Rxcj0352.9+1941 Cluster By Chandra And Gmrt Observations, S. S. Sonkamble, S. K. Kadam, Surajit Paul, M. B. Pandge Dec 2024

Cool-Core, X-Ray Cavities, And Cold Front Revealed In Rxcj0352.9+1941 Cluster By Chandra And Gmrt Observations, S. S. Sonkamble, S. K. Kadam, Surajit Paul, M. B. Pandge

Open Access archive

This paper presents a comprehensive analysis of 30 ks Chandra and 46.8 ks (13 h) 1.4 GHz GMRT radio data on the cool-core cluster RXCJ0352.9+1941 to investigate AGN activities at its core. This study confirms a pair of X-ray cavities at projected distances of about 10.30 and 20.80 kpc, respectively, on the NW and SE of the X-ray peak. GMRT L band (1.4 GHz) data revealed a bright radio source associated with the core of this cluster hosting multiple jet-like emissions. The spatial association of the X-ray cavities with the inner pair of radio jets confirms their origin due to …


Recent Advancements In Selenium Nanoconstructs As A Potential Carrier In Cancer Therapy, Ritu Kudarha, Viola Colaco, Ashutosh Gupta, Sanjay Kulkarni Dec 2024

Recent Advancements In Selenium Nanoconstructs As A Potential Carrier In Cancer Therapy, Ritu Kudarha, Viola Colaco, Ashutosh Gupta, Sanjay Kulkarni

Open Access archive

Cancer cells require energy to carry out essential tasks, grow, and survive, like all other body cells. The pathophysiological process of cancer is a complex one. The cytotoxicity, lack of selectivity, generation of multidrug resistance, and proliferation of stem-like cells are some of the issues facing current chemotherapy. To this end, nanoconstructs with unique inherent properties, including optical, magnetic, and electrical, with a desired nano range (<100 nm), have shown remarkable applications. There are numerous significant categories into which nanomaterials employed in cancer therapy can be divided. These nanomaterials, which target the immune system, tumour microenvironment, and cancer cells, have been modified for various cancer therapies to improve drug capacity and bioavailability, reduce toxicity, and improve specificity. The distinct bioactivities of inorganic metallic NPs include silver (Ag), gold (Au), cerium (Ce), iron (Fe), selenium (Se), titanium (Ti), platinum (Pt) and zinc (Zn), giving them a prominent position among other NPs. Selenium nanoparticles (SeNPs), particularly, have garnered attention due to their unique pharmacological properties. As an essential trace element, Se forms the active site in selenoproteins like selenocysteine (Sec), which regulates the physiological redox balance through its oxidoreductase activity. SeNPs have emerged as promising therapeutic agents in recent decades due to their reduced toxicity compared to Se, which has a narrow therapeutic window. SeNPs also exhibit synergistic effects with the therapeutic cargo, enhancing the anticancer activity. In this review, we have discussed the pharmacological effects of SeNPs, their pharmacological protective role against inflammation and oxidative stress-mediated conditions, and the latest advances in their synthesis and functionalization, utilized in cancer medication delivery systems, targeted drug delivery systems and gene delivery systems. In addition, we present an update on the most recent reported preclinical research involving the utilization of SeNPs in cancer treatment.


Harnessing Trichoderma Mycoparasitism As A Tool In The Management Of Soil Dwelling Plant Pathogens, Srishti Singh, Alok Kumar Singh, Bhubaneswar Pradhan, Sudipta Tripathi Dec 2024

Harnessing Trichoderma Mycoparasitism As A Tool In The Management Of Soil Dwelling Plant Pathogens, Srishti Singh, Alok Kumar Singh, Bhubaneswar Pradhan, Sudipta Tripathi

Open Access archive

Maintaining and enhancing agricultural productivity for food security while preserving the ecology and environment from the harmful effects of toxicants is the main challenge in modern monoculture farming systems. Microbial biological agents can be a promising substitute for traditional synthetic pesticides to manage plant diseases. Trichoderma spp. are soil-dwelling ascomycete fungi and are common biocontrol agents against diverse phytopathogens. Trichoderma-based biocontrol techniques can regulate and control soil-borne plant diseases through mechanisms such as mycoparasitism, the production of antibiotics and hydrolytic enzymes, rhizo-sphere competence, the effective competition for available resources, induction of plant resistance and facilitation of plant growth. Numerous secondary …


Association Of Maxillofacial Injuries With Traumatic Brain Injuries In Paediatric Patients: A Case–Control Study, Baranya Shrikrishna Suprabha, Michael Lowery Wilson, Joanna Baptist, Sadhvi Shankar Subramanian Dec 2024

Association Of Maxillofacial Injuries With Traumatic Brain Injuries In Paediatric Patients: A Case–Control Study, Baranya Shrikrishna Suprabha, Michael Lowery Wilson, Joanna Baptist, Sadhvi Shankar Subramanian

Open Access archive

Background: Traumatic brain injuries (TBIs) are among the most challenging conditions to accurately diagnose in children, and many TBIs are underdiagnosed. Patients with maxillofacial injury may be at risk for TBI. The objective of this study was to analyse the association between maxillofacial injuries and TBI among paediatric patients. Analysis of the factors associated with the occurrence of TBI among paediatric patients with maxillofacial injuries was the secondary objective. Method: This case-control study included 192 cases defined as paediatric patients with maxillofacial injuries and 192 controls defined as all paediatric patients with traumatic injuries to other body locations and with …


Correction To: Role And Promise Of Health Policy And Systems Research In Integrating Rehabilitation Into The Health Systems (Health Research Policy And Systems, (2024), 22, 1, (143), 10.1186/S12961-024-01235-2), Abdul Ghafar, Abdulgafoor M. Bachani, Adnan A. Hyder, Alarcos Cieza Dec 2024

Correction To: Role And Promise Of Health Policy And Systems Research In Integrating Rehabilitation Into The Health Systems (Health Research Policy And Systems, (2024), 22, 1, (143), 10.1186/S12961-024-01235-2), Abdul Ghafar, Abdulgafoor M. Bachani, Adnan A. Hyder, Alarcos Cieza

Open Access archive

Following publication of the original article [1] it was reported that there was an error in the affiliations of Pierre Côté and Rajiv Reebye. Pierre Côté was mistakenly assigned affiliation 5 instead of 15, and Rajiv Reebye was mistakenly assigned affiliation 15 instead of their missing affiliation, now affiliation 16. The incorrect affiliations were: Pierre Côté5, Rajiv Reebye155Department of Noncommunicable Diseases, Rehabilitation and Disability, World Health Organization, Geneva, Switzerland. 15Institute for Disability and Rehabilitation Research and Faculty of Health Sciences, Ontario Tech University, Ontario, Canada. The correct affiliations are: Pierre Côté15, Rajiv …


D-Prism: A Global Survey-Based Study To Assess Diagnostic And Treatment Approaches In Pneumonia Managed In Intensive Care, Luis Felipe Reyes, Cristian C. Serrano-Mayorga, Zhongheng Zhang, Isabela Tsuji Dec 2024

D-Prism: A Global Survey-Based Study To Assess Diagnostic And Treatment Approaches In Pneumonia Managed In Intensive Care, Luis Felipe Reyes, Cristian C. Serrano-Mayorga, Zhongheng Zhang, Isabela Tsuji

Open Access archive

Background: Pneumonia remains a significant global health concern, particularly among those requiring admission to the intensive care unit (ICU). Despite the availability of international guidelines, there remains heterogeneity in clinical management. The D-PRISM study aimed to develop a global overview of how pneumonias (i.e., community-acquired (CAP), hospital-acquired (HAP), and Ventilator-associated pneumonia (VAP)) are diagnosed and treated in the ICU and compare differences in clinical practice worldwide. Methods: The D-PRISM study was a multinational, survey-based investigation to assess the diagnosis and treatment of pneumonia in the ICU. A self-administered online questionnaire was distributed to intensive care clinicians from 72 countries between …


Global, Regional, And National Burden Of Hiv/Aids, 1990–2021, And Forecasts To 2050, For 204 Countries And Territories: The Global Burden Of Disease Study 2021, Austin Carter, Magdalene K. Walters, Deepa Jahagirdar, Edmond D. Brewer Dec 2024

Global, Regional, And National Burden Of Hiv/Aids, 1990–2021, And Forecasts To 2050, For 204 Countries And Territories: The Global Burden Of Disease Study 2021, Austin Carter, Magdalene K. Walters, Deepa Jahagirdar, Edmond D. Brewer

Open Access archive

Background: As set out in Sustainable Development Goal 3.3, the target date for ending the HIV epidemic as a public health threat is 2030. Therefore, there is a crucial need to evaluate current epidemiological trends and monitor global progress towards HIV incidence and mortality reduction goals. In this analysis, we assess the current burden of HIV in 204 countries and territories and forecast HIV incidence, prevalence, and mortality up to 2050 to allow countries to plan for a sustained response with an increasing number of people living with HIV globally. Methods: We used the Global Burden of Diseases, Injuries, and …


The Impacts Of Using Geogebra On Students’ Perceptions And Achievement In Learning Trigonometric Ratios, Robert Carlos Trejo Dec 2024

The Impacts Of Using Geogebra On Students’ Perceptions And Achievement In Learning Trigonometric Ratios, Robert Carlos Trejo

Theses and Dissertations

GeoGebra, a dynamic mathematics software, was used to study high school students’ perceptions and achievements in learning trigonometric ratios. The study addresses a critical gap in the literature concerning the use of GeoGebra for understanding trigonometric concepts, particularly in fostering conceptual clarity and problem-solving skills. Rooted in a constructivist pedagogical framework, the research examines how GeoGebra facilitates interactive and exploratory learning environments that encourage active student engagement and deeper comprehension of trigonometric ratio principles.

The study employed a quantitative approach to evaluate the efficacy of GeoGebra. Quantitative data focused on student achievement in solving trigonometric ratio problems through pre- and …


A Genotyping Array For The Globally Invasive Vector Mosquito, Aedes Albopictus, Luciano Veiga Cosme, Margaret Corley, Thomas Johnson, Dave W. Severson, Guiyun Yan, Xiaoming Wang, Nigel Beebe, Andrew Maynard, Mariangela Bonizzoni, Ayda Khorramnejad, Ademir Jesus Martins, José Bento Pereira Lima, Todd P. Livdahl Dec 2024

A Genotyping Array For The Globally Invasive Vector Mosquito, Aedes Albopictus, Luciano Veiga Cosme, Margaret Corley, Thomas Johnson, Dave W. Severson, Guiyun Yan, Xiaoming Wang, Nigel Beebe, Andrew Maynard, Mariangela Bonizzoni, Ayda Khorramnejad, Ademir Jesus Martins, José Bento Pereira Lima, Todd P. Livdahl

Biology

Background: Although whole-genome sequencing (WGS) is the preferred genotyping method for most genomic analyses, limitations are often experienced when studying genomes characterized by a high percentage of repetitive elements, high linkage, and recombination deserts. The Asian tiger mosquito (Aedes albopictus), for example, has a genome comprising up to 72% repetitive elements, and therefore we set out to develop a single-nucleotide polymorphism (SNP) chip to be more cost-effective. Aedes albopictus is an invasive species originating from Southeast Asia that has recently spread around the world and is a vector for many human diseases. Developing an accessible genotyping platform is essential in …


Capitella Teleta Gets Left Out: Possible Evolutionary Shift Causes Loss Of Left Tissues Rather Than Increased Neural Tissue From Dominant-Negative Bmpr1, Nicole B. Webster, Néva P. Meyer Dec 2024

Capitella Teleta Gets Left Out: Possible Evolutionary Shift Causes Loss Of Left Tissues Rather Than Increased Neural Tissue From Dominant-Negative Bmpr1, Nicole B. Webster, Néva P. Meyer

Biology

Background: The evolution of central nervous systems (CNSs) is a fascinating and complex topic; further work is needed to understand the genetic and developmental homology between organisms with a CNS. Research into a limited number of species suggests that CNSs may be homologous across Bilateria. This hypothesis is based in part on similar functions of BMP signaling in establishing fates along the dorsal-ventral (D-V) axis, including limiting neural specification to one ectodermal region. From an evolutionary-developmental perspective, the best way to understand a system is to explore it in a wide range of organisms to create a full picture. Methods: …


Bound Botany - New England Fall Archival Book, Serena Yu, Special Collections, Fleet Library Dec 2024

Bound Botany - New England Fall Archival Book, Serena Yu, Special Collections, Fleet Library

12th Baker & Whitehill Student Artists' Book Contest 2026

Entry for the 12th Baker & Whitehill Student Artists' Book Contest. Opening reception and award ceremony Wednesday, February 25, 2026 at 6:30pm, Fleet Library, 1st Floor Main Reading Room. Juror: Gabrielle Reed.


How Many Tiny Snails? Circumscription Of Three Species Of Pyrgulopsis (Mollusca: Gastropoda: Hydrobiidae)In Nevada Mountain Springs, Trenton Meadows Dec 2024

How Many Tiny Snails? Circumscription Of Three Species Of Pyrgulopsis (Mollusca: Gastropoda: Hydrobiidae)In Nevada Mountain Springs, Trenton Meadows

Theses and Dissertations

The springsnail genus Pyrgulopsis is one of the most diverse groups of freshwater gastropods in North America (Hershler, 2014), with many species displaying high levels of endemism (Hurt, 2003). This study attempts to circumscribe three putative species of springsnails: Pyrgulopsis serrata, Pyrgulopsis marcida, and a newly identified clade, referred to as Lineage C, from the Ruby Lake National Wildlife Refuge, Nevada, USA and nearby springs. Using an integrative taxonomic approach, we combined morphological, anatomical, and molecular data to examine species boundaries and evolutionary relationships.

Many lines of evidence were considered to determine species boundaries. Phylogenetic analysis of the mitochondrial …


Density Functional Theory And Machine Learning Analysis Of C—C Reductive Coupling From Terminal Cyanido And Cyaphido Complexes, Roberto Magdiel Escobar Dec 2024

Density Functional Theory And Machine Learning Analysis Of C—C Reductive Coupling From Terminal Cyanido And Cyaphido Complexes, Roberto Magdiel Escobar

Theses and Dissertations

Carbon–carbon (C–C) bond activation has gained increased attention as a direct method for the synthesis of pharmaceuticals and industrial chemistry. Due to the thermodynamic stability and kinetic inaccessibility of the C–C bonds, however, activation of C–C bonds by homogeneous transition-metal catalysts under mild homogeneous conditions is still a challenge. Most of the systems in which the activation occurs either have aromatization or relief of ring strain as the primary driving force. The activation of unstrained C–C bonds of phosphaalkynes does not have this advantage. This study employs Density Functional Theory (DFT) calculations using the Gaussian16 package to elucidate and compare …


Feasibility Study On Microwave Glucose Level Monitoring, Ricardo Cepeda Dec 2024

Feasibility Study On Microwave Glucose Level Monitoring, Ricardo Cepeda

Theses and Dissertations

Diabetes management heavily relies on regular blood glucose monitoring, which traditionally involves invasive techniques. In recent years, significant research has been directed towards developing non-invasive glucose monitoring methods, particularly using electromagnetic waves. This study explores the feasibility of detecting blood glucose levels non-invasively by measuring the resonant frequency shifts of an antenna, influenced by the dielectric properties of blood. Microwave measurement techniques have garnered attention due to their ability to safely penetrate human tissue and detect biochemical markers like glucose. While previous studies have established a link between glucose concentration and dielectric properties, many techniques suffer from poor sensitivity or …


Tanzania Design Build 2024, Elli S. Berger, Samantha M. Maher, Victoria J. Maestas Dec 2024

Tanzania Design Build 2024, Elli S. Berger, Samantha M. Maher, Victoria J. Maestas

Architectural Engineering

In 2007 David Lambert, a Cal Poly ARCE alumnus, was inspired to build a school in Tanzania after spending time in Kenya completing his senior project. With the support of multiple Cal Poly faculty members, he assembled a team to launch what would become his master’s program project. Since no existing organizations could support their efforts, the team founded their own initiative, the Mbeses Initiative for Sustainable Design (MISD). The Cal Poly team shared their design ideas with multiple volunteer groups in Tanzania and eventually connected with Fr. Setonga who helped the initiative gain traction. A few years later, the …


Analyzing Tms 402 -22 : Design Of Special Reinforced Masonry Shear Walls, Tristan D. Aranda Dec 2024

Analyzing Tms 402 -22 : Design Of Special Reinforced Masonry Shear Walls, Tristan D. Aranda

Architectural Engineering

This experiment examines possible inconsistencies in the TMS 402-22 masonry code between Section 7.3.2.5 and Section 9.3.5.6.2, regarding the requirements for special boundary elements in Special Reinforced Masonry Shear Walls. By investigating the two sections, it can be determined whether the two sections are in accordance with each other regarding aspect ratio. Tensile forces and strains are calculated respectively for each wall and block type and are compared to the respective tensile yield forces and ductile strains. This determines which respective boundary elements go past yield and become ductile. Based on this determination, recommendations can be made to the …


Synthesizing And Characterizing Some Pharmaceutical Resins Using Mannich Bases And Studying Their Biological Activity, Tamador Ali Mahmood Dec 2024

Synthesizing And Characterizing Some Pharmaceutical Resins Using Mannich Bases And Studying Their Biological Activity, Tamador Ali Mahmood

Baghdad Science Journal

Mannich bases functional groups were used, which is considered an inventive phenol formaldehyde resin was created in this study. The project was divided into two phases. The first portion involves creating a monomer of Mannich bases through a condensation reaction. The reaction occurs between aromatic aldehyde (P-hydroxy benzaldehyde) and primary amines like (Metoclopramide, trimethoprim, 2-aminobenzothiazoly, sulfamethoxazole, and 4-amino antipyrine) and with minor amines such as Carbazol. By condensing Mannich bases made in part one with formaldehyde and phenol, the second stage included making phenol formaldehyde resin with Mannich bases. The synthesized resins (Phenol-formaldehyde) have been characterized. The characterization was done …


Densenet Model For Binary Glaucoma Classification Performance Assessment With Texture Feature, Wildan Jameel Hadi, Amal Sufiuh Ajrash, Sahar Muneam Salman, Mays Jalal Jasim, Mina Taha Ibrahim Dec 2024

Densenet Model For Binary Glaucoma Classification Performance Assessment With Texture Feature, Wildan Jameel Hadi, Amal Sufiuh Ajrash, Sahar Muneam Salman, Mays Jalal Jasim, Mina Taha Ibrahim

Baghdad Science Journal

The retina is an important portion of the eye because images of it are used by doctors to diagnose numerous eye diseases such as glaucoma, diabetic retinopathy, and cataracts. Indeed, segmented retinal imaging is a powerful tool for detecting unusual growths in the eye area as well as determining the size and structure of the optic disc. The combination of digital image processing and deep learning techniques enables the development of automated approaches for detecting glaucoma. Within this framework, the objective of this study is to achieve prompt detection of glaucoma by utilizing a DenseNet-121 Network in conjunction with texture …