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Assessment Of Medical Laboratory Science Student Motivation And Perceived Transfer Of Knowledge Towards Information Literacy, Shannon Jongeward Jan 2025

Assessment Of Medical Laboratory Science Student Motivation And Perceived Transfer Of Knowledge Towards Information Literacy, Shannon Jongeward

Theses and Dissertations

Information literacy skills are a cornerstone of higher education as they allow students to effectively locate, evaluate, and utilize information from various sources. Evidence-Based Practice, a process commonly used in healthcare for decision making, incorporates using the best available research, one’s clinical expertise, and the patient’s values. Information literacy is foundational to developing evidence-based practice skills. Medical Laboratory Scientists (MLS) utilize evidence-based practice to assist in making decisions about clinical laboratory tests and processes to ensure quality in testing and the appropriate use of resources; therefore, it is important for MLS programs to include elements of evidence-based practice into their …


Energy Systems Optimization Techniques In The Oil And Gas Industry With Special Attention On Oil Field Reciprocating Compressors, Sean Jainarine Jan 2025

Energy Systems Optimization Techniques In The Oil And Gas Industry With Special Attention On Oil Field Reciprocating Compressors, Sean Jainarine

Theses and Dissertations

The oil and natural gas exploration and production industry is undergoing rapid growth, resulting in an increased number of operational wells and heightened potential for air emissions from oil and natural gas sources. Within production sites, compressors play a pivotal role and are often regarded as the "heart of a manufacturing plant" in the oil and gas sector. These crucial devices are designed to compress air or other gases to pressures higher than atmospheric pressure. Gas compression is typically achieved using devices with rotating blades or cylinders featuring reciprocating compressors while are essential for operations demanding high-pressures in small packages. …


The Ability Of The Millon Pre-Adolescent Clinical Inventory (M-Paci) To Distinguish Between Adhd And Non-Adhd Clinical Groups, Michael Jowkar Jan 2025

The Ability Of The Millon Pre-Adolescent Clinical Inventory (M-Paci) To Distinguish Between Adhd And Non-Adhd Clinical Groups, Michael Jowkar

Theses and Dissertations

The M-PACI is a personality scale based on Millon’s biosocial personality theory designed to measure emerging personality patterns in pre-adolescents (9-12 years old). There is minimal published research on this inventory, particularly in clinical contexts. For this study, we used a data set collected at a Midwestern private practice clinic where children are assessed for ADHD and learning disabilities. This study looks at how those diagnosed with ADHD differ in emerging personality patterns and current clinical signs scales compared to those in a clinical sample who have not been diagnosed with ADHD. Some studies have shown differences between children diagnosed …


Perceptions Of Emotional Abuse As A Partial Function Of The Abuser-Victim Gender Dyad, Kaitlyn Kidder Jan 2025

Perceptions Of Emotional Abuse As A Partial Function Of The Abuser-Victim Gender Dyad, Kaitlyn Kidder

Theses and Dissertations

Emotional abuse affects approximately half of people in an intimate relationship, yet it is often not considered intimate partner violence (IPV) on its own (Dokkedahl et al., 2022; Leemis et al., 2022). Despite the prevalence, there is a lack of consistency on the definition of emotional abuse and IPV as well as a lack of clarity of what acts qualify for these terms. Past research has largely focused on IPV, specifically physical or sexual abuse, in heterosexual relationships with a male perpetrator and female victim. Few studies have explored the interactions of the gender of the victim and perpetrator in …


Exploring Student-Athlete Perceptions On Nil Opportunities In The Cannabinoid Industry, Katherine Klimchock Jan 2025

Exploring Student-Athlete Perceptions On Nil Opportunities In The Cannabinoid Industry, Katherine Klimchock

Theses and Dissertations

The introduction of Name, Image, and Likeness (NIL) regulations in collegiate athletics has created new financial and branding opportunities for student-athletes. Simultaneously, there has been an evolving legal landscape surrounding cannabinoids both at the state and National Collegiate Athletic Association (NCAA) levels. This dissertation in practice explores this emerging intersection by examining student-athlete perceptions of NIL opportunities with cannabinoid brands and highlighting the perceived advantages and disadvantages of such deals. This dissertation in practice consists of three artifacts. Artifact I provides essential background information on NIL, cannabinoids, and the House v. NCAA settlement. Recognizing the legal, institutional, and cultural shifts …


An Intersectional Exploration And Analogue Investigation Of Transgender And Gender Diverse Bi+ Women’S Preferences For Sexual Violence Vulnerability Reduction Interventions, Sara K. Kuhn Jan 2025

An Intersectional Exploration And Analogue Investigation Of Transgender And Gender Diverse Bi+ Women’S Preferences For Sexual Violence Vulnerability Reduction Interventions, Sara K. Kuhn

Theses and Dissertations

Transgender and gender diverse (TGD) bisexual+ (bi+, e.g., pansexual, polysexual) women disproportionately experience sexual violence victimization and their acceptability of applicable interventions is under-researched. Online self-report data was collected from 240 ethnoracially diverse bi+ adult American women, who identified as TGD (n = 69) or cisgender (cis; n = 171), and who read standardized descriptions of interventions. TGD bi+ women found intervention descriptions inclusive of their sexual and gender identities—and those including in-person active resistance strategy instruction (bystander/self-defense)—more acceptable. Intervention descriptions with alcohol use and/or sexual activity reduction components were largely found to be less acceptable. Intervention elements of importance …


Examining A Year One Sor Implementation: A Mixed-Method Study Of Teacher Experiences And Student Literacy Scores, Christine Litzinger Jan 2025

Examining A Year One Sor Implementation: A Mixed-Method Study Of Teacher Experiences And Student Literacy Scores, Christine Litzinger

Theses and Dissertations

With increasing national and legislative mandates prioritizing SoR practices, many schools are shifting their literacy practices to align classroom instruction, interventions, and screening to follow reading research, which can require a shift in pedagogy for individual educators and schools. This exploratory sequential mixed-methods study explored a year one implementation of the Science of Reading (SoR) in a mid-size midwestern school district during their first year of across-district literacy reform. Qualitative case study interviews were conducted of K-3 Classroom teachers (4) and literacy coaches (4). Emergent themes from the findings included value in high fidelity professional development, challenges related to resource …


Doctoral Student Mentoring: A Quantitative Analysis Of Faculty And Student Perceptions And Expectations, Laura Margaret Look Jan 2025

Doctoral Student Mentoring: A Quantitative Analysis Of Faculty And Student Perceptions And Expectations, Laura Margaret Look

Theses and Dissertations

Doctoral student success is heavily influenced by the quality of mentoring and advising relationships with graduate faculty, yet doctoral student completion rates remain at a low rate of around 50%. The purpose of this quantitative study was to examine the mentoring relationships of doctoral students by surveying doctoral students and graduate faculty who mentor graduate students to identify their expectations for the mentor and mentee in the mentoring relationship. Data were collected from 155 students and 68 faculty in the spring 2024 semester at the University of North Dakota, a Midwest R2 institution. Nonparametric statistical analysis revealed several misalignments between …


Extreme Environment Tribological Studies Of Multifunctional Materials, Matt Malusky Jan 2025

Extreme Environment Tribological Studies Of Multifunctional Materials, Matt Malusky

Theses and Dissertations

This research examines polymer wear behaviors across polyether-etherketone (PEEK) and polylactic acid (PLA) composites in varying environmental conditions. Tribological investigations of ceramic and intermetallic coatings are explored in the context of material selection for lunar operation. In the first study, PEEK composites incorporating ternary nanolaminate ceramics, termed MAB and MAX phases, were tested in varying temperature environments above and below their expected glass transition temperatures to evaluate their tribological performance in comparison to a non-reinforced PEEK substrate. Results showed that under ambient conditions, both MoAlB (MAB phase) and Cr2AlC (MAX phase) ceramics stabilize the friction coefficient compared to pure PEEK, …


Strengthening Traffic Safety Laws On The Crow Indian Reservation, Darcy Merchant Jan 2025

Strengthening Traffic Safety Laws On The Crow Indian Reservation, Darcy Merchant

Theses and Dissertations

The Crow Indian reservation is located in south-central Montana. The reservation is one of the largest land-based tribes in Montana, encompassing an area of over three thousand square miles. The reservation borders the state of Wyoming to the south and the Northern Cheyenne Indian reservation to the east. The reservation features a comprehensive transportation system that encompasses tribal, county, state, and federal roadways. Drivers and passengers who travel on these roadways are at higher risk for fatal and severe injury-related motor vehicle crashes than those in other reservations. This situation largely stems from the critical absence of targeted traffic safety …


Chemical Looping As An Enabling Technology For Low-Carbon Energy Production, Junior Neguieh Domkam Nasah Jan 2025

Chemical Looping As An Enabling Technology For Low-Carbon Energy Production, Junior Neguieh Domkam Nasah

Theses and Dissertations

Growth in global gross domestic product has historically been tied with high-carbon energy sources. Development of new low-carbon energy technologies is thus key to achieving a de-coupling of energy demand from economic growth. This dissertation evaluates the technical feasibility of a small-scale low-carbon solution referred to as Combined Hydrogen, Heat and Power (CH2P), a synthesis gas to hydrogen chemical looping process. The CH2P process is based on the steam-iron process and adopts multiple batch reactors to convert syngas in a two-step approach. First, the syngas is partially oxidized by reducing Magnetite (Fe3O4) to Wüstite (FeO) followed by complete oxidation in …


Military Recruitment And Retention: A Policy And Practice Analysis, Orly Naum Jan 2025

Military Recruitment And Retention: A Policy And Practice Analysis, Orly Naum

Theses and Dissertations

The ongoing decline in United States military recruitment and retention presents a growing challenge to sustaining an effective All-Volunteer Force (AVF), particularly within the United States Coast Guard, a branch that has historically been underrepresented in academic research, and across the Department of Defense (DoD). This convergent mixed methods study examined how generational cohorts and individual motivations influence recruitment and retention, integrating quantitative data from the Defense Manpower Data Center (DMDC) and qualitative survey responses from a veteran-rich collegiate population. The quantitative analysis revealed statistically significant differences in Armed Forces Qualification Test (AFQT) scores between Generation Z (GenZ) and Generation …


Student Participation In Informal Resolution: Examination Of Impact Factors On Recidivism And Student Perceptions Of Institutional Care And Fairness, Linnea Rose Nelson Jan 2025

Student Participation In Informal Resolution: Examination Of Impact Factors On Recidivism And Student Perceptions Of Institutional Care And Fairness, Linnea Rose Nelson

Theses and Dissertations

This exploratory case study, conducted at the University of North Dakota (UND), examined factors influencing recidivism and student perceptions of institutional care and fairness among participants in the piloted Informal Resolution (IR) option. A restorative justice (RJ)-informed alternative to the traditional student conduct process, the IR is offered to students charged with first-time, low-level violations of UND’s code of conduct. This study aimed not only to evaluate the new process but also to respond to recent calls from scholars and practitioners for more extensive research on the intersection of RJ and student conduct outcomes. Sherman’s (1993) defiance theory provided the …


Using Machine Learning To Investigate Weather Impacts On Crop Yield For Probabilistic, Climate-Informed Predictive Crop Breeding, Levi Newell Jan 2025

Using Machine Learning To Investigate Weather Impacts On Crop Yield For Probabilistic, Climate-Informed Predictive Crop Breeding, Levi Newell

Theses and Dissertations

As the world’s population continues to grow, the importance of food security willonly continue to increase, with some estimates requiring a global increase in food production between 59 and 98% by 2050. The agriculture industry is also a crucial economic driver, with the industry supporting 20% of the state of North Dakota’s workforce, and with a total valuation of $41.3 billion. The economic importance of this industry and the challenges of future growth prompt a need for data driven decision making into the future, particularly with predictive crop breeding. This is the method by which crops are developed that are …


Which University Faculty Are Successful Researchers? Developing And Testing Measures Of Research Competence To Predict Faculty Research Motivation And Success, Muhammad Salahuddin Jan 2025

Which University Faculty Are Successful Researchers? Developing And Testing Measures Of Research Competence To Predict Faculty Research Motivation And Success, Muhammad Salahuddin

Theses and Dissertations

University faculty play a pivotal role in producing research that leads to positive social change through the creation of new knowledge, enhancement of higher education quality, and improved university rankings. Faculty produce more when they feel competent, autonomously motivated, and acknowledged. Past studies have measured faculty research competencies using self-report scales that may contain biases, potentially leading to significant discrepancies in research outcomes. My program of research – a three-article dissertation – aimed to develop and validate the test-based measures of faculty research competence that can more reliably predict faculty research success. The three studies provide an enhanced understanding of …


Synthesis And Characterization Of Silicon-Containing Ternary Transition Metal Borides For High Performance Applications, Godswill Ngige Jan 2025

Synthesis And Characterization Of Silicon-Containing Ternary Transition Metal Borides For High Performance Applications, Godswill Ngige

Theses and Dissertations

Binary borides are well known for their exceptional mechanical and thermal properties, including high strength, high melting points, outstanding hardness, and excellent chemical stability, making them suitable for high-temperature structural applications such as components in hypersonic vehicles, jet engines, nose cones, and the leading edges of aircraft. Despite these advantages, they are inherently brittle and suffer from low fracture toughness, limiting their ability to absorb impact or resist crack propagation.

To this end, attention shifted to ternary transition metal borides which are materials composed of a transition metal, boron, and a third element. These ternary compounds exhibit a broader range …


The Effect Of Salaciousness, Consistency, And Timing Of Disclosure On Alibi Believability In The Eyes Of A Jury, Jasper Allen Schmidtwood Jan 2025

The Effect Of Salaciousness, Consistency, And Timing Of Disclosure On Alibi Believability In The Eyes Of A Jury, Jasper Allen Schmidtwood

Theses and Dissertations

Past research indicates a prevalent distrust of alibi evidence, coined by Olson and Wells (2004) as the alibi skepticism hypothesis. This inherent distrust prompts inquiries into the factors that enhance or undermine the credibility of alibi evidence in a trial. Utilizing attribution theory (Allison et al., 2012; Weiner, 2010), this study investigates the elements contributing to the believability of alibi statements, specifically the impact of alibi consistency, timing of disclosure, and the salaciousness of the alibi statement on jurors' perceptions of the defendant's character. Participants were randomly assigned to one of twelve conditions and read a mock trial summary that …


From Theory To Practice: Addressing The Operational Challenges Of School Principals, Darin Murry Scherr Jan 2025

From Theory To Practice: Addressing The Operational Challenges Of School Principals, Darin Murry Scherr

Theses and Dissertations

School principals play a crucial role in the effectiveness of educational institutions, yet many enter leadership positions lacking adequate preparation for operational responsibilities. This Dissertation in Practice examines the challenges principals face in managing financial, staffing, and facility operations and the impact of these challenges on principal retention. Using a qualitative multiple-case study approach, the research investigates the experiences of new and veteran principals within Bismarck Public Schools to identify gaps in their operational preparedness.Findings highlight five key themes: (1) gaps in financial and budgetary training, (2) the role of mentorship and support systems, (3) balancing instructional leadership with operational …


Mixed Method Case Study Of The Silver Program: Nohwi Báyáni Bidádadil’Įį - Watching Over Our Elder, Cameron Ray Smith Jan 2025

Mixed Method Case Study Of The Silver Program: Nohwi Báyáni Bidádadil’Įį - Watching Over Our Elder, Cameron Ray Smith

Theses and Dissertations

This program effects case study provides a comprehensive case review of Apache Behavioral Health Services (ABHS) Nohwi Báyáni Bidádadil’įį – Watching Over Our Elders (Silver Program). The research aims to understand the program’s effectiveness in identifying, addressing, and reducing Elder abuse/neglect/and exploitation. Assess how the program has used the Elder Abuse Suspicion Index (EASI), assess community partners and ABHS staff knowledge/familiarity with the program, and whether the Silver Program is effective.

To achieve the research aim, I reviewed four data sources: ABHS Electronic Health Record (EHR), ABHS internal survey, interviews with community partners, and artifact review of the Silver Program. …


Speech-Language Pathology Graduate Programs: What Influences Students To Apply?, Emily Stephens Jan 2025

Speech-Language Pathology Graduate Programs: What Influences Students To Apply?, Emily Stephens

Theses and Dissertations

Speech-Language Pathologists (SLPs) are licensed professionals trained to work with various age ranges who have communication, feeding, and/or swallowing difficulties. The entry level education for an SLP to actively practice is a master’s degree. To fill the many vacant and needed SLP jobs across the country, it is necessary for SLP master’s programs to admit highly qualified students into their programs, resulting in many competent SLPs entering the workforce to fill the current job openings. Minot State University’s SLP master’s program has experienced a significant decline in graduate applications over the past decade. There is limited research specific to the …


Advancing Human-Computer Interaction Systems Through Explainable And Secure Ai Integration, Ifiok Udoidiok Jan 2025

Advancing Human-Computer Interaction Systems Through Explainable And Secure Ai Integration, Ifiok Udoidiok

Theses and Dissertations

As artificial intelligence (AI) systems increasingly shape how humans interact with digital environments, the need for transparency, security, and robustness in intelligent decision making has become critical. This thesis explores how explainable and secure AI techniques can be integrated into modern human-computer interaction (HCI) systems to enhance trust, resilience, and alignment with human operators.

We present three related studies, each addressing a distinct challenge in the design of human-centered AI. First, we apply XAI methods, specifically Local Interpretable Model-Agnostic Explanations (LIME), to deep learning (DL) based CAPTCHA solvers. By interpreting model attention patterns, we uncover exploitable weaknesses in text CAPTCHA …


Synthesis And Characterization Of Additive Manufactured Functional Composites For Biomedical Applications, Alexander Thorne Jan 2025

Synthesis And Characterization Of Additive Manufactured Functional Composites For Biomedical Applications, Alexander Thorne

Theses and Dissertations

This dissertation investigates the synthesis and characterization of 3D printed polymer composites, with engineered porosity and both natural and synthetic additives, using fused deposition modeling (FDM) and selective laser sintering (SLS) for potential biomedical applications. The structural, mechanical, tribological, and surface behavior of these composites were evaluated with respect to their suitability for orthopedic load-bearing implants and scaffolds. In the first phase, PEEK-based composites reinforced with 10 or 20 wt% carbon fibers or 20 wt% E-glass fibers were fabricated using FDM with varying infill densities of 30-100% to introduce porosity. Results revealed that loading additives, infill densities, and porosity play …


Targeted Coaching In The Detroit Promise Path: A Thematic Network Analysis Of Current Challenges And Opportunities For Student Success, Maryse Danielle Wilson Jan 2025

Targeted Coaching In The Detroit Promise Path: A Thematic Network Analysis Of Current Challenges And Opportunities For Student Success, Maryse Danielle Wilson

Theses and Dissertations

The Detroit Promise Program is one of the many college promise programs operating within the United States that offers full college tuition coverage to students within the city who meet certain residential criteria. Detroit’s population has one of the highest proportions of Black and first-generation students and the lowest average socioeconomic class in the country. From the time of the Promise Program’s launch until now it has seen minor improvements in college degree competition rates, but this rate is still low compared to the national average. The Detroit Promise Path, which is an off branch of the Detroit Promise Program, …


Zaasijiwan: An Indigenized Health Communication Framework For American Indian And Alaska Native Communities, Jennifer Wolf Jan 2025

Zaasijiwan: An Indigenized Health Communication Framework For American Indian And Alaska Native Communities, Jennifer Wolf

Theses and Dissertations

The Zaasijiwan Framework represents an Indigenized health communication model developed to enhance the cultural relevance, trust, and effectiveness of public health messaging for American Indian and Alaska Native (AI/AN) communities. This qualitative study integrated Indigenous and Western public health knowledge to inform the development of the framework. A comprehensive literature review and two rounds of key informant interviews with health communication professionals informed the design of the framework. Findings emphasized the importance of community co-creation and strengths-based narratives, along with other framework elements, in overcoming medical mistrust and improving health outcomes. The final framework offers public health professionals, Tribal, and …


Public Perceptions Of Fracking And Anti-Fracking Activism: A Theory Of Planned Behavior Approach And Its Implications For Environmental Policy, Okhumode Hector Yakubu Jan 2025

Public Perceptions Of Fracking And Anti-Fracking Activism: A Theory Of Planned Behavior Approach And Its Implications For Environmental Policy, Okhumode Hector Yakubu

Theses and Dissertations

Hydraulic fracturing, or fracking, has become one of the most contentious energy technologies of the 21st century, drawing support for its economic and energy security benefits and opposition due to its perceived environmental and health risks. This study applies the Theory of Planned Behavior (TPB) to examine the psychological, social, and informational factors that shape public perceptions of fracking and motivate anti-fracking activism. Using a nationally representative sample of U.S. adults (N = 522), this research investigates how attitudes, subjective norms, perceived behavioral control, and domain-specific knowledge predict support or opposition to fracking, as well as intentions to engage in …


The Gender Wage Gap In An Online Labor Market: The Cost Of Interruptions, Abi Adams, Kotaro Hara, Kristy Milland, Chris Callison-Burch Jan 2025

The Gender Wage Gap In An Online Labor Market: The Cost Of Interruptions, Abi Adams, Kotaro Hara, Kristy Milland, Chris Callison-Burch

Research Collection School Of Computing and Information Systems

This paper analyses gender differences in working patterns and wages on Amazon Mechanical Turk, a popular online labour platform. Using information on 2 million tasks, we find no gender differences in task selection nor experience. Nonetheless, women earn 20% less per hour on average. Gender differences in working patterns are a significant driver of this wage gap. Women are more likely to interrupt their working time on the platform with consequences for their task completion speed. A follow-up survey shows that the gender differences in working patterns and hourly wages are concentrated amongst workers with children.


Clinical Pharmacology And Medication Safety: A Remote Learning Elective Designed For Senior Medical Students, Elizabeth B. Graham, William T. Wightkin, Curt R. Bay, Uzoma S. Ikonne Jan 2025

Clinical Pharmacology And Medication Safety: A Remote Learning Elective Designed For Senior Medical Students, Elizabeth B. Graham, William T. Wightkin, Curt R. Bay, Uzoma S. Ikonne

Department of Biomedical and Translational Sciences Faculty Publications

In the United States, medical educators have expressed concern that an integrated and condensed pre-clerkship curriculum risks leaving gaps in student pharmacology knowledge. This study evaluates a remote-learning clinical pharmacology elective that integrates fundamental pharmacology concepts and principles of medication safety and explores how the course impacts senior medical students' self-reported readiness for residency. Clinical Pharmacology and Medication Safety is a remote elective course for senior medical students. The course integrates a review of basic pharmacology with clinical pharmacology topics through case-based learning sessions led by clinical pharmacists and physicians. To evaluate the elective's effectiveness, students in the fall and …


Hiv Protein Tat Dysregulates Multiple Pathways In Human Ipscs- Derived Microglia, Liam Liyang Guo, Robert Jiang, Yan Cheng, Brooke Russell, Yan Y. Sanders, Ming-Lei Guo Jan 2025

Hiv Protein Tat Dysregulates Multiple Pathways In Human Ipscs- Derived Microglia, Liam Liyang Guo, Robert Jiang, Yan Cheng, Brooke Russell, Yan Y. Sanders, Ming-Lei Guo

Department of Biomedical and Translational Sciences Faculty Publications

In the era of combined antiretroviral therapy, around 50% of chronic HIV (+) individuals show varying degrees of memory and cognitive deficiency (NeuroHIV), a phenomenon of accelerated brain aging. HIV protein transactivator of transcription (TAT) has been well-accepted as a risk factor contributing to NeuroHIV through dysregulating microglia (Mg) functions. Previous studies have demonstrated that HIV-TAT can affect lipid metabolism, immune responses, autophagy, and senescence in rodent Mg. However, due to the significant species differences between rodent and human Mg (hMg), it is essential to take caution when interpreting the results obtained from rodent models into human conditions. For the …


Implementing A Chatbot To Promote Hereditary Breast & Ovarian Cancer Genetic Screening In Women's Health: Identifying Barriers And Facilitators To Screening Adoption, Easton N. Wollney, Shireen Madani Sims, Luisel J. Ricks-Santi, Elizabeth Eddy, Daniel Wiesman, Carla L. Fisher Jan 2025

Implementing A Chatbot To Promote Hereditary Breast & Ovarian Cancer Genetic Screening In Women's Health: Identifying Barriers And Facilitators To Screening Adoption, Easton N. Wollney, Shireen Madani Sims, Luisel J. Ricks-Santi, Elizabeth Eddy, Daniel Wiesman, Carla L. Fisher

Department of Biomedical and Translational Sciences Faculty Publications

Background

To promote genetic screening among women at risk for hereditary breast and ovarian cancer (HBOC), the American College of Obstetricians and Gynecologists recommends that risk assessment be integrated into practice. Chatbots like the Genetic Information Assistant (Gia®) are increasingly implemented to expand access to hereditary genetic screening. Factors that impact chatbot implementation for HBOC risk screening and women's uptake are not fully realized. To refine implementation strategies prior to full scale implementation, we sought to identify women's perceived facilitators/barriers to adopting Gia screening in a rural population within a large healthcare system in the southern United States.

Methods

We …


Loneliness Associates With Endothelial Dysfunction In A Community-Based Cohort: A Pilot Study And Translational Approach, Yvonne Baumer, Brian A. Tirado, Lola R. Ortiz-Whittingham, Andrew S. Baez, Cristhian A. Gutierrez-Huerta, Laurel G. Mendelsohn, Abhinav Saurabh, Joshua A. Jacobs, Marcus R. Andrews, Valerie M. Mitchell, Billy S. Collins, Antwan Jones, Danielle M. Schwartz, Anca D. Dobrian, Michael V. Stanton, Tiffany M. Powell-Wiley Jan 2025

Loneliness Associates With Endothelial Dysfunction In A Community-Based Cohort: A Pilot Study And Translational Approach, Yvonne Baumer, Brian A. Tirado, Lola R. Ortiz-Whittingham, Andrew S. Baez, Cristhian A. Gutierrez-Huerta, Laurel G. Mendelsohn, Abhinav Saurabh, Joshua A. Jacobs, Marcus R. Andrews, Valerie M. Mitchell, Billy S. Collins, Antwan Jones, Danielle M. Schwartz, Anca D. Dobrian, Michael V. Stanton, Tiffany M. Powell-Wiley

Department of Biomedical and Translational Sciences Faculty Publications

Loneliness is known to be an important contributor to cardiovascular disease (CVD). However, little is known about the impact of loneliness on endothelial barrier integrity, a crucial hallmark of CVD development and progression. In this study, we aimed to investigate how loneliness might impact the endothelium. We found greater perceived loneliness associated with the product of circulating epinephrine and TNFα (E/T), which, in turn, associated with lower VE-cadherin on endothelial cells in an ex vivo experiment. Additionally, circulating plasma levels of soluble VE-cadherin were associated significantly with subclinical CVD. To explore the mechanistic aspects of these associations, we measured the …