Digital Commons Network^™

Exploring The Immune Landscape Of The Tumour Microenvironment In Meningiomas And The Role Of Immune Infiltration In Meningioma Models, Ting Zhang

Peninsula Medical School Theses

Background: Meningiomas are the most common primary intracranial tumours, ranging from benign to highly aggressive forms. While surgery is effective for low-grade meningiomas, certain grade 1 tumours, as well as grade 2, 3, and recurrent cases are more aggressive and require new therapeutic approaches. Immunotherapy shows promise, however, the role of tumour microenvironment (TME), particularly tumour-associated macrophages (TAMs), in meningiomas remains poorly understood, especially concerning genomic alterations. Aims: To investigate the immune landscape of meningiomas classified by grades, genotypes and methylation classes (MCs), and to elucidate the role of the TAMs in meningioma progression utilising a patient-derived 3D co-culture model.Methods: …

Targeting Aldehyde Dehydrogenases In Nf2-Null Meningioma And Schwannoma, Libby Williams

Peninsula Medical School Theses

Meningioma and schwannoma are tumours of the brain and nervous system that are frequently driven by loss or mutation of the gene NF2, which encodes the tumour suppressor protein Merlin. Dysregulated Hippo pathway signalling, caused by NF2 loss, drives overexpression of aldehyde dehydrogenase 1A1 (ALDH1A1) in NF2-null schwannoma. High expression of ALDH1A1, and the related isoform ALDH1A3 have been identified as markers of cancer stem cell activity and have been correlated with poor prognosis and chemoresistance in several cancers. This project aims to clarify the role ofaldehyde dehydrogenase (ALDH) enzymes in meningioma tumours and evaluate their potential as future therapeutic …

Navigating The Transition: Modelling The Path For Net-Zero European Building Sector, Souran Chatterjee, Gergely Molnar, Benedek Kiss, Daniel Topal, Diana Ürge-Vorsatz

School of Geography, Earth and Environmental Sciences

Transition towards a net-zero building sector offers substantial potential to mitigate climate change impacts andthus plays a pivotal role in meeting the goals set forth in the Paris Agreement. Stakeholders often use mathematical models to understand the true potential for mitigating emissions by reducing the energy demand of thebuilding sector. However, the existing models rarely provide insights into net-zero pathways for both the residential and tertiary buildings as this is a complex sector to calculate the future pathways towards net-zero.Hence, uncertainties in the associated policy decisions persist. Therefore, this study uses the High-EfficiencyBuilding (HEB) energy model to calculate the energy …

Comparative Evaluation Of Swabbing Sites For Omicron Variant Detection In Pcr Testing, Tom Fowler, Edward Blandford, David Chapman, Matthias E Futschik, Raghavendran Kulasegaran-Shylini, Sarah Tunkel, Carolyn Lewis, Alasdair Fellows, Ellie Sheppard, Leanne Mccabe, Peter Marks, Paul E Klapper, Andrew Dodgson, Malur Sudhanva, Mike Kidd, Andy Vail, Susan Hopkins, Tim Peto

School of Biomedical Sciences

PURPOSE: The Omicron variant of SARS-CoV-2 raised concerns about the best sampling sites for PCR testing, with early indications suggesting throat swab samples were better than nasal swab samples. Our study evaluated the sensitivity of detecting SARS-CoV-2 across different swabbing sites.

METHODS: Participants undergoing testing at NHS Test and Trace sites in England provided self-collected samples using nose only, throat only, and combined nose and throat swabs, which were analysed by realtime PCR.

RESULTS: Among 815 participants, combined swabs had higher viral concentrations than nose only or throat only swabs. Sensitivity for detecting SARS-CoV-2 by PCR was 91 % for …

Assessing Total Mortality Following Seabird Wrecks Given Variable Data Quantity And Quality: The Cassin’S Auklet Die-Off, Timothy Jones, Julia K. Parrish, Parker Maccready, Lisa T. Ballance, David W. Bradley, Hillary K. Burgess, Jane E. Dolliver, James T. Harvey, Trevor Joyce, Kirsten Lindquist, Jacqueline Lindsey, Hannahrose M. Nevins, Jan Roletto, Laurie Wilson, Charlie Wright

Faculty Research, Scholarly, and Creative Activity

Mass mortality events (MMEs) of seabirds are becoming more frequent as the global climate warms. Often documented via beached bird surveys, methods for estimating event-wide mortality are needed that can accommodate regional differences in carcass deposition and data quality/quantity. We develop a framework for estimating mortality from beached bird counts, extending existing approaches through the novel application of ocean circulation modeling to assess beaching likelihood. We applied our framework to the 2014/15 Cassin’s auklet (Ptychoramphus aleuticus) MME, which spread across three regions (central California, northern California-through-Washington, British Columbia) with varying data quality/quantity. Our best mortality estimate of ∼400 000 (estimates …

Conservation Benefits Of A Large Marine Protected Area Network That Spans Multiple Ecosystems, Joshua G. Smith, Cori Lopazanski, Christopher M. Free, Julien Brun, Clarissa Anderson, Mark H. Carr, Joachim Claudet, Jenifer E. Dugan, Jacob G. Eurich, Tessa B. Francis, David A. Gill, Scott L. Hamilton, Kristin Kaschner, David Mouillot, Peter T. Raimondi, Richard M. Starr, Shelby L. Ziegler, Daniel Malone, For Full Author List, See Comments Below

Faculty Research, Scholarly, and Creative Activity

Marine protected areas (MPAs) are widely implemented tools for long-term ocean conservation and resource management. Assessments of MPA performance have largely focused on specific ecosystems individually and have rarely evaluated performance across multiple ecosystems either in an individual MPA or across an MPA network. We evaluated the conservation performance of 59 MPAs in California's large MPA network, which encompasses 4 primary ecosystems (surf zone, kelp forest, shallow reef, deep reef) and 4 bioregions, and identified MPA attributes that best explain performance. Using a meta-analytic framework, we evaluated the ability of MPAs to conserve fish biomass, richness, and diversity. At the …

From Shocks To Solidarity And Superstition: Exploring The Foundations Of Faith, Aidin Hajikhameneh, Laurence R. Iannaccone

Faculty Research, Scholarly, and Creative Activity

Additive shocks can substantially increase cooperation in otherwise standard public goods game experiments. We study shocks that randomly adjust players’ earnings by a fixed positive or negative amount reported at the end of each round. These adjustments change neither the return to players’ contributions nor the information about other group members. We compare results across four treatments that employ the same group-level adjustment algorithm but frame it differently, with pre-play descriptions that range from omitting all useful information to accurately revealing its 50/50 random nature. In each treatment, overall contributions run about 50% higher than those obtained in the standard …

Can Household Water Sharing Advance Water Security? An Integrative Review Of Water Entitlements And Entitlement Failures, Melissa Beresford, Ellis Adams, Jessica Budds, Leila M. Harris, Wendy Jepson, Tennille Marley, Chloe Nguyen, Amber Pearson, Anaís Delilah Roque, Asher Y. Rosinger, Sameer H. Shah, Matthew Stellbauer, Amber Wutich

Faculty Research, Scholarly, and Creative Activity

An increasing number of studies find that water sharing—the non-market transfer of privately held water between households—is a ubiquitous informal practice around the world and a primary way that households respond to water insecurity. Yet, a key question about household water sharing remains: is water sharing a viable path that can help advance household water security? Or should water sharing be understood as a symptom of water insecurity in wait for more formalized solutions? Here, we address this question by applying Sen’s entitlement framework in an integrative review of empirical scholarship on household water sharing. Our review shows that when …

Empowering Customer Service With Generative Ai: Enhancing Agent Performance While Navigating Challenges, Charles Costa, Souvick Ghosh

Faculty Research, Scholarly, and Creative Activity

Introduction. As large language models (LLMs), such as GPTs, become more intelligent, a key area of exploration is how these technologies can improve the customer experience. Contrary to common belief, many consumers, including Gen Z, prefer human-provided customer service, illustrating the importance of human-AI collaboration in the space. Method. By leveraging the author’s real-world knowledge of enterprise knowledge management and customer service delivery, we reviewed numerous literature about AI, knowledge management, and service design and synthesised practical insights for industry professionals to build a successful AI strategy. Analysis. We examined the gap between academic research on generative AI and how …

Label-Free Visualization And Segmentation Of Endothelial Cell Mitochondria Using Holotomographic Microscopy And U-Net, Raul Michael, Tallah Modirzadeh, Tahir Bachar Issa, Patrick Jurney

Faculty Research, Scholarly, and Creative Activity

Understanding the physiological processes underlying cardiovascular disease (CVD) requires examination of endothelial cell (EC) mitochondrial networks, because mitochondrial function and adenosine triphosphate production are crucial in EC metabolism, and consequently influence CVD progression. Although current biochemical assays and immunofluorescence microscopy can reveal how mitochondrial function influences cellular metabolism, they cannot achieve live observation and tracking changes in mitochondrial networks through fusion and fission events. Holotomographic microscopy (HTM) has emerged as a promising technique for real-time, label-free visualization of ECs and their organelles, such as mitochondria. This nondestructive, noninterfering live cell imaging method offers unprecedented opportunities to observe mitochondrial network dynamics. …

Optogenetic Methods To Stimulate Gamma Motor Neuron Axons Ex Vivo, Apoorva Karekal, Remie Mandawe, Cameron Chun, Sai Kiran Byri, Danitza Cheline, Serena Ortiz, Shawn Hochman, Katherine A. Wilkinson

Faculty Research, Scholarly, and Creative Activity

It is challenging to stimulate gamma motor neurons, which are important regulators of muscle spindle afferent function, without also recruiting alpha motor neurons. Here, we test the feasibility of stimulating gamma motor neuron axons using optogenetics in two transgenic mouse lines. We used an ex vivo muscle–nerve preparation in adult mice to monitor muscle spindle afferent firing, which should increase in response to gamma motor neuron-induced lengthening of the sensory region of the muscle spindle. A force transducer measured alpha motor neuron-mediated twitch contractions. Blue LED light (470 nm; 1–5 mW) was delivered via a light guide to the sciatic …

Does Social Capital Mitigate Managerial Self-Dealing? Evidence From Insider Trading, Sung Gon Chung, Jimmy Lee, Sang Hyun Park

Research Collection School Of Accountancy

In this study, we examine whether the social capital surrounding the firm’s corporate headquarters mitigates managerial self-dealing in the form of opportunistic insider trading. We find strong evidence that the level of social capital in the region surrounding the firm’s headquarters is negatively and significantly associated with insider trading profitability. We also find that the negative association between social capital and insider trading profitability is more pronounced when governance is weaker and corporate opacity is higher, instances where insiders have greater opportunities to trade on their private information. Further analyses on the potential mechanisms suggest that the negative association is …

Bogging Down Investors: An Unintended Consequence Of Litigation Risk, Siwen Fu, Ke Wang, Liandong Zhang, Liu Zheng

Research Collection School Of Accountancy

Securities litigation risk is a well-recognized yet underexplored source of financial reporting complexity or unreadability. This study examines the effect of litigation risk on the readability of corporate financial reports. The 1999 Silicon Graphics Inc. (SGI) court ruling unexpectedly reduced litigation risk for firms within the Ninth Circuit Court’s jurisdiction. Using a difference-in-differences design centered on the SGI court ruling, we find that, while the readability of financial reports generally declines over the sample period, treated firms in the Ninth Circuit experience a comparatively smaller decline in readability than control firms in other states after the ruling. Put differently, treated …

Breaking The Language Barriers? Machine Translation Technology And Analysts’ Forecasts For Firms With Foreign Operations, Bingxu Fang, Pengkai Lin

Research Collection School Of Accountancy

We study the impact of machine translation technology on analysts’ forecasts for firms with foreign operations. Exploiting the staggered rollout of Google Translate’s support for translating foreign languages into English, we find that U.S. analysts improve their forecast accuracy for firms with substantial business exposure to the corresponding foreign countries. We obtain similar evidence using an international sample of analysts covering firms outside their home countries. The improvement in forecast accuracy is greater for analysts with limited language skills or brokerage resources to process foreign information. Further analysis suggests that analysts raise more questions about firms’ foreign exposure during conference …

The Vietnam War And The Regional Context, Wen-Qing Ngoei

Research Collection School of Social Sciences

This chapter traces Southeast Asia’s overall pro-U.S. trajectory from before and through the American war in Vietnam, a process in which the region’s anticommunist nationalists collaborated with the United States and Britain to gain, and remain in, power. Between the late 1940s through the early 1960s, indigenous anticommunist elites in Thailand and the Philippines rose to political dominance with U.S. assistance; in Malaya and Singapore they did so with British support. The United States and Britain, with their Malayan and Singaporean allies, would influence developments within Indonesia that precipitated the Indonesian Army’s rightwing coup of 1965, a transformative event that …

Exploring The Impact Of Collaboration Processes On Policy Networks Success: A Case Study Of Food Policy Councils, Beomgeun Cho, In Hae Noh, April M. Roggio, Luis Felipe Luna-Reyes

Research Collection School of Social Sciences

Innovative forms of collaborative governance have evolved to address a diversity of wicked problems. Collaboration processes involved in these forms of governance appear to have a paradoxical nature, where the necessary inclusiveness and diversity of actors may also be important obstacles for a successful collaboration. We apply theories of collaborative and network governance, and fuzzy-set Qualitative Comparative Analysis, to explore the impact of collaboration process characteristics (network density, diversity, inclusion and participation) on 12 food policy councils. Our findings suggest that collaborative arrangements where diverse stakeholders have equal and inclusive access to active deliberation constitute one path to effective outcomes.

Interactive Effects Of Intrasexual Competitiveness, Same-Sex Competition, And Physical Attractiveness On Temporal Discounting, Jose C. Yong, Indra Alam Syah Aziz, Hualin Xiao, Norman P. Li

Research Collection School of Social Sciences

Studies have shown that men discount the future and prefer immediate-but-smaller over delayed-but-larger rewards when exposed to mating opportunities (e.g., attractive opposite-sex targets) or threats (e.g., same-sex competition) whereas women's discounting in response to similar cues appears mixed, suggesting that mating-motivated discounting is primarily a male phenomenon. Importantly, this line of research has not yet examined the role of individual difference variables as well as how the attractiveness of potential mates and perceptions of competition jointly influence discounting rates. We conducted a novel test of the effect of trait intrasexual competitiveness (ISC) using dating profiles varying on target attractiveness and …

Discontent In The World City Of Singapore, Gordon Tan, Jessie P. H. Poon, Orlando Woods

Research Collection College of Integrative Studies

A burgeoning literature on ‘left behind’ places has emerged that captures the backlash against globalisation and highlights the locales that lag world cities. This paper integrates the ‘left behind’ and world cities literatures through the lens of discontent in the context of Singapore, using sentiment analysis and topic modelling as well as interviews with local professionals to unpack the multidimensional aspects of discontent. Focusing on the Singapore–India Comprehensive Economic Cooperation Agreement that spurred discontent directed at foreign Indian professionals, we show that the worlding generated by transnational flows has accentuated intra-urban inequality through racialisation and spatialisation of financial business and …

China's Global Leadership Aspirations And Domestic Support For Climate Policy, Chen Xiang, Terry Van Gevelt

Research Collection College of Integrative Studies

In recent years, China has pivoted towards a global leadership role in mitigating and adapting to climate change. Notwithstanding the complex political economic reasons underlying China's global leadership aspirations, we are interested in seeing whether the associated national discourse championed by the state increases domestic support for climate policy. That is, do China's international leadership aspirations foster a unifying sense of national pride among the domestic population, thereby lending support to the legitimacy of the state and expediting the implementation of costly domestic climate policies? To test our hypothesis, we enumerated a vignette experiment embedded with conjoint analysis to a …

Book Review: The Malayan Emergency: Revolution And Counterinsurgency At The End Of Empire By Karl Hack, Wen-Qing Ngoei

Research Collection College of Integrative Studies

This book review critiques the scholarly contributions of historian Karl Hack's new book on the Malayan Emergency.

A Survey Of Multilingual Large Language Models, Libo Qin, Qiguang Chen, Yuhang Zhou, Zhi Chen, Yinghui Li, Lizi Liao, Min Li, Wanxiang Che, Philip S. Yu

Research Collection School Of Computing and Information Systems

Multilingual large language models (MLLMs) leverage advanced large language models to process and respond to queries across multiple languages, achieving significant success in polyglot tasks. Despite these breakthroughs, a comprehensive survey summarizing existing approaches and recent developments remains absent. To this end, this paper presents a unified and thorough review of the field, highlighting recent progress and emerging trends in MLLM research. The contributions of this paper are as follows. (1) Extensive survey: to our knowledge, this is the pioneering thorough review of multilingual alignment in MLLMs. (2) Unified taxonomy: we provide a unified framework to summarize the current progress …

Eagle Accountant - 2025, Georgia Southern University

Eagle Accountant

• Accounting Advisory Council
• Accreditation & Rankings
• Eagles on Pennsylvania Avenue
• Students Tackle CPA Pipeline Crisis with “DAD Day” Initiative
• Cover Story: The Mooneys: Rooted in Purpose
• Guest Speakers as a Career Path Initiative
• Fraud Story: The Price of Desperation
• Learning Through Debate
• NASBA Annual Meeting
• Accounting Quiz Bowl
• Faculty Research Spotlight 
• Undergraduate Spotlight
• Graduate Spotlight
• Student Organizations & Activities 
• Faculty Awards, Service, & Publications 
• Alumni Notes & Obituaries 

Is Common Behavior Considered Moral? The Role Of Perceived Others' Motives In Moral Norm Inferences And Motivation About Environmental Behavior, Kimin Eom, Bryan Kwok Cheng Choy

Research Collection School of Social Sciences

The present research examines how inferences about moral norms from descriptive norms change by perceptions of others' motives in the context of environmental behavior. When individuals think that many others engage in an environmental behavior (e.g., water and energy conservation) for prosocial (vs. proself) motives, they infer moralization about the behavior in a given context. They infer stronger injunctive norms about the behavior and expect others to experience moral outrage at violation of the moral standard (e.g., wasting water and energy). The moral norm perceptions predict people's motivation to engage in environmental behavior themselves. We further show that expected guilt …

Umbrella Review Of Meta-Analyses On The Risk Factors, Protective Factors, Consequences And Interventions Of Cyberbullying Victimization, K. T. A. Sandeeshwara Kasturiratna, Andree Hartanto, Crystal H. Y. Chen, Eddie M. W. Tong, Nadyanna M. Majeed

Research Collection School of Social Sciences

The increasing prevalence of cyberbullying victimization has become a commonplace issue globally. Although research has explored various predictors and consequences of cyberbullying victimization, most focus on a narrow range of variables or contexts, highlighting the need to comprehensively review and synthesize the wealth of empirical findings. We conducted a systematic review of meta-analyses on cyberbullying victimization, incorporating 56 meta-analyses and 296 effect sizes (sample size range 421–1,136,080, sample size median 53,183; searched via EBSCOhost ERIC, EBSCOhost PsycInfo, PubMed, Scopus, Web of Science, 13 cyberbullying-related journals, Google Scholar and ProQuest Dissertations and Theses) to address the following critical questions: (1) What …

Understanding Sociability Through Mandevillean Pride: Comments On Robin Douglass's Mandeville's Fable, Antong Liu

Research Collection School of Social Sciences

There is ‘a tendency to evaluate philosophical theories of human nature as more accurate or adequate when they are more attractive or flattering, not when they are more truthful,’ claim two contemporary moral psychologists (Flanagan and Hu 2011: 312). While this tendency may not be as widely shared as these scholars expect, the flip side of their claim indeed captures a factual truth: philosophers seldom avoid attacks on their theories and even their personalities when they insiston exposing the dark side of human nature. Indeed, not all philosophers attacked for this reasonlose their popularity, as numerous readers of Machiavelli and …

No Consistent Evidence For Between- And Within-Person Associations Between Objective Social Media Screen Time And Body Image Dissatisfaction: Insights From A Daily Diary Study, Adalia Y. H. Goh, Andree Hartanto, K. T. A. Sandeeshwara Kasturiratna, Nadyanna M. Majeed

Research Collection School of Social Sciences

With the abundance of social media content that promotes unrealistic beauty standards, there are growing concerns about the potential negative impact of social media use on body image satisfaction. While some studies highlight negative associations, others present null effects, pointing to methodological limitations like biased and unreliable self-reported screen time measures and a focus on singular platforms. Addressing these gaps, our study employed a daily diary method to objectively measure social media screen time across six major platforms (Twitter, Reddit, TikTok, YouTube, Instagram, and Facebook), alongside daily body image dissatisfaction among 252 young adults (Mage = 21.67 years, 67.77% female) …

Learning By Teaching With Deliberate Errors Promotes Argumentative Reasoning, Sarah Shi Hui Wong

Research Collection School of Social Sciences

Reasoning and arguing well lies at the core of thinking and constructing knowledge about complex, controversial issues. Leveraging the techniques of learning by teaching and deliberate erring, the present study developed and tested a novel intervention—learning by misteaching—to boost argumentative reasoning. University students (N = 208) were trained on argumentation strategies and studied a dual-position argumentative text on a controversial topic using one of three learning methods: notetaking, correct teaching, or misteaching. The notetaking group prepared to be tested and wrote study notes while generating good arguments about the topic, whereas both teaching groups prepared to teach and wrote a …

Andrew Phang (Gen. Ed.), Pioneer, Polymath And Mentor: The Life And Legacy Of Yong Pung How, Kwan Ho Lau, Bryan Leow

Research Collection Yong Pung How School Of Law

Many know the story of modern Singapore in broad outline. When the country attained independence in 1965, it was not industrialised and fishing villages still dotted the landscape. By 1990, GDP per capita had risen to around US$13,000, far exceeding its neighbours and on par with Hong Kong and New Zealand. A further three decades on, Singapore today boasts gleaming skyscrapers, well-developed infrastructure and a high degree of trust by residents and investors alike in its government.

Ai Characterisations And Their Legal Implications, Jerrold Tsin Howe Soh

Research Collection Yong Pung How School Of Law

This chapter examines the difficult legal characterisation problems that artificially intelligent systems raise and explores how different characterisations of artificial intelligence (AI) shape practical legal outcomes. Three reasons are offered for the legal difficulty with characterising AI. First, answers to characterisation problems are inherently subjective and perspective-driven, particularly when the subject is an intangible technological system. Second, AI technology is especially difficult to define since the field typically proceeds on inexact anthropomorphic metaphors. Third, AI characterisation problems raise difficult sub-problems, particularly in determining how autonomous an AI system is. The chapter thus argues that a range of plausible AI characterisations …

Financial Regulation, Aurelio Gurrea-Martinez, Nydia Remolina Leon

Research Collection Yong Pung How School Of Law

No abstract provided.