Digital Commons Network^™

Comparing Elements Of The Community Of Inquiry Framework In An Asynchronous And Synchronous Student Success Course In Nursing School, Megan Mcinnis

Graduate Research Theses & Dissertations

This study explored the impact of course delivery modality—asynchronous versus synchronous—on students’ perceptions of Teaching, Social, and Cognitive Presence as outlined in the Community of Inquiry (CoI) framework. Conducted at a nursing college, the study involved students enrolled in a student success course offered in both formats. Quantitative data, using the CoI Survey Instrument, were collected through pre- and post-course surveys and analyzed with independent t tests to determine whether statistically significant differences existed within and between modalities. Results indicated that both course formats supported high levels of perceived presence across all three domains. In the asynchronous section, a statistically …

An Exploration Of Social Isolation’S Effects On The Gastrointestinal And Metabolic Health Of A Social Mammal, Daniel Adam Nuccio

Graduate Research Theses & Dissertations

Human health can be impacted considerably by subjective feelings of loneliness, resulting in mental illness and the dysregulation of normal cardiovascular, immune and endocrine functioning. This occurs because social isolation serves as a form of chronic stress for social mammals, spurring physiological responses akin to those associated with more standard forms of stress. On account of their highly social nature, prairie voles (Microtus ochrogaster) subsequently have become one of the model organisms of choice for investigating the effects of social isolation on the development of disease in social mammals.

This dissertation seeks to expand the scientific community’s understanding of the …

Efficient Algorithms For Nearest Correlation Matrix Computation With Missing Data, Ibrahim Eniola Oyeyinka

Graduate Research Theses & Dissertations

This thesis investigates efficient algorithms for computing the Nearest Correlation Matrix (NCM) under incomplete financial data. Correlation matrices are vital in portfolio optimization and risk management, yet empirical estimates often violate symmetry, positive semidefiniteness, and unit diagonal conditions due to missing observations. Two projection-based methods are analyzed: the Modified Alternating Projections (MAP) and Anderson Acceleration (AA). Theoretical analysis using convex optimization and normal cone characterization supports numerical evaluation on synthetic and real-world stock-return matrices (550×550, 2020–2025). Missing data are modeled through Missing Completely at Random (MCAR) and Not Missing at Random (NMAR) mechanisms. The results show that AA converges faster …

Deep Underground Neutrino Experiment Data Caching With Frontier, Alexander Rahe

Graduate Research Theses & Dissertations

The Deep Underground Neutrino Experiment (DUNE) is an unprecedented long baseline neutrino experiment that aims to measure various neutrino mixing parameters. With state-of-the-art technology, DUNE will measure neutrino mixing angles (θ13, θ12, θ23) and a Charge-Parity (CP) violating phase (δcp) with precision and will determine the elusive mass ordering. In order to accomplish these goals, scientists all over the world must have quick and reliable access to the data provided by the DUNE detectors. The data caching system known as Frontier is a distributed database caching system that was previously used in other large particle physics experiments for this purpose. …

Audit Culture And A Nonprofit In Northern Illinois, Onyenum Ruth Udoh

Graduate Research Theses & Dissertations

Audit culture has become a defining feature of nonprofit life, shaping how organizations balance accountability to donors with responsibility to their communities. While existing scholarship often highlights large or international NGOs, less is known about how small and mid-sized nonprofits in the United States experience these pressures. This study focused on nonprofit in DeKalb County, Illinois, to examine how audits, donor restrictions, and accountability demands influence nonprofit practices, priorities, and relationships with their communities. Grounded in ethnographic fieldwork and organizational anthropology, I conducted eight weeks of participant observation and semi-structured interviews with seven staff across leadership, finance, program, and administrative …

Occupational Choice And Social Mobility, Samuel Solomon

Yale Graduate School of Arts and Sciences Dissertations

This dissertation examines how individuals make occupational choices and how that shapes economic success, social mobility, and the labor market.

The first chapter uses population-wide administrative data from Finland to examine the underlying drivers and aggregate implications of occupational following—when children enter into their parent’s occupation—for the labor market, social mobility, and total output. I first document that occupational following is a widespread feature of the labor market. Second, I show that pre-labor market multidimensional skills and educational choice statistically explain 19% of following among all 43 two-digit occupations, and 53% among white collar ones. Third, I use an instrumental …

Probing Non-Perturbative Qcd With Jet Substructure Measurements At Star, Youqi Song

Yale Graduate School of Arts and Sciences Dissertations

In high-energy particle collisions, when incoming quarks and gluons (partons) exchange a large momentum during scattering, the outgoing partons undergo parton showers by primarily radiating off gluons successively. Hadrons are formed when the parton energies are sufficiently low. The collimated sprays of particles created through this process are called jets. Studies of the internal structure of jets, known as jet substructure, can provide insight into Quantum Chromodynamics (QCD), the theory that governs the interaction between partons and their formation into hadrons. In this thesis, I present two sets of measurements of jet substructure observables that are sensitive to the theoretically …

Hypnosis: An Evidenced Based Treatment, Gregory P. Brown

Psychiatry & Behavioral Health Faculty Research

Review of meta analyses and systemic review level studies of hypnosis in the treatment of anxiety, burnout, and depression.

Functional And Traditional Medical Management Of Endometriosis: An Integrative Review, Madison G. Daniels

Senior Honors Theses

Endometriosis, a progressive disease that affects many women worldwide, has been managed primarily through hormonal medication, pain management and surgical intervention. However, there is a growing desire among women to use more natural and holistic methods to control the progression of this disease as well as effectively manage the severe symptoms that accompany it. This integrative review examines the efficacy of functional management as compared to traditional medical management. The pathophysiology of each treatment method and provide statistical evidence as to its efficacy. The progression of the disease, symptom management, and related side effects are all taken into consideration in …

The Dynamic Integration Of National Culture In Organizational Structure For Entrepreneurial Success, Qianyu Lim

Senior Honors Theses

The impact of culture on management decisions has been heavily researched and discussed in the academic setting. However, the tools and frameworks currently applied in cultural studies present a static version of culture at a certain point in time. As entrepreneurship and its counterpart, intrapreneurship, arise to help create competitive advantage in a quickly shifting economic market, these points raise the question of the opportunity surrounding the consideration of culture as a living model in an equally dynamic business environment. To do so, a reiterative version of Bain’s Structure-Conduct-Performance paradigm will be used to illustrate the impact of culture in …

Bytes, Banter, And The Bible: An Interdisciplinary Account Of Objective Meaning, Cameron Bonin

Senior Honors Theses

The claim that the Bible has objective meaning is contested in a postmodern world. This claim can be more persuasively defended when it is addressed by insights from multiple disciplines. In particular, the field of computer science is apt to illuminate the concept of meaning through its reflection on the nature of languages and its concern with the accurate transmission of information. By synthesizing insights from the field of computer science, such as that of Claude Shannon, with Nicholas Wolterstorff’s use of speech-act theory, the concept of meaning can be understood more clearly. Consequently, this synthesis assists in answering questions …

Perspectives On Demyelinating Disease: An Overview Of Multiple Sclerosis, Nathaniel Howard Williams

Senior Honors Theses

Multiple sclerosis (MS) is a demyelinating disease of central nervous system (CNS), primarily concerning oligodendrocytes, the myelinating cells of the CNS and the neurons that are ensheathed in myelin. MS is the most common demyelinating disease, affecting as many as 300,000 yearly in the United States alone. Much debate centers on whether MS onset is primarily caused by autoimmune reactions or intrinsic dysfunction in oligodendrocytes, which prompts an immune-mediated response. Those who review the current literature on MS may become quickly overwhelmed by the volume and variety of available material. The purpose of this review is to present a …

Communicating The “Already, Not Yet” Through The Visual Arts, Hadley Jacobs

Senior Honors Theses

The “already, not yet” is a theological concept that addresses the tension of Christian living. Although believers are free from sin’s power, they are not free from its effects. This thesis examines the “already, not yet” through a series: one graphite drawing, one colored pencil drawing, and one oil painting. The graphite drawing depicts a ruined building, the colored pencil drawing depicts a building being rebuilt, and the oil painting depicts a restored building. They represent the fallen state of man, the state of believers on earth, and the state of believers after being restored, respectively. Together, these pieces create …

Red Diplomacy And Black Liberation: The Cold War's Influence On The Naacp, Natalie A. Filkins

Honors College Theses

The Civil Rights Movement and Cold War occurred concurrently, yet the two events represent entirely different moments in American history. While one marked a moment of immense social growth, the other illustrated how widespread paranoia can influence a nation’s decision making. This thesis centers on an examination of how the National Association for the Advancement of Colored People (”NAACP”) utilized international bodies, like the United Nations (“UN”), to bring global attention toward the mistreatment of those of African descent. My analysis relied on internal documents from the NAACP’s offices, and the organization’s magazine publication, The Crisis. I examined volumes 55-68 …

Chemoproteomic Profiling Of A Carbon-Stabilized Gold(Iii) Macrocycle Reveals Cellular Engagement With Hmox2, Sailajah Gukathasan, Chibuzor Ngozi Olelewe, Libby Ratliff, Jong H. Kim, Alyson M. Ackerman, J. Robert Mccorkle, Sean Parkin, Gunnar F. Kwakye, Jill M. Kolesar, Samuel G. Awuah

Chemistry Faculty Publications

In this work, we discovered a novel organometallic gold(III) macrocycle, Au-Mac1, that demonstrates anticancer potency in a panel of triple-negative breast cancer cells (TNBC), and based on this complex, a biotinylated-Au-Mac1 probe was designed for target identification via chemoproteomics, which uncovered the engagement of HMOX2 of the heme-energy metabolism pathway. Using orthogonal chemical biology and molecular biology approaches, including immunoblotting, flow cytometry, and cellular thermal shift assays, it was confirmed that Au-Mac1 engages HMOX2 in cells. Downstream effects of Au-Mac1 on the depletion of mitochondrial membrane proteins and bioenergetics point to the potential role of HMOX2 in cancer. Importantly, Au-Mac1 …

Electrochemical Observation And Ph Dependence Of All Three Expected Redox Couples In An Extremophilic Bifurcating Electron Transfer Flavoprotein With Fused Subunits, Debarati Das, Wassim El Housseini, Monica Brachi, Shelley D. Minteer, Anne-Frances Miller

Chemistry Faculty Publications

Bifurcating enzymes employ energy from a favorable electron transfer to drive unfavorable transfer of a second electron, thereby generating a more reactive product. They are therefore highly desirable in catalytic systems, for example, to drive challenging reactions such as nitrogen fixation. While most bifurcating enzymes contain air-sensitive metal centers, bifurcating electron transfer flavoproteins (bETFs) employ flavins. However, they have not been successfully deployed on electrodes. Herein, we demonstrate immobilization and expected thermodynamic reactivity of a bETF from a hyperthermophilic archaeon, Sulfolobus acidocaldarius (SaETF). SaETF differs from previously biochemically characterized bETFs in being a single protein, representing a …

Functional Utility Of Gold Complexes With Phosphorus Donor Ligands In Biological Systems, Adedamola S. Arojojoye, Samuel G. Awuah

Chemistry Faculty Publications

Metallo-phosphines are ubiquitous in organometallic chemistry with widespread applications as catalysts in various chemical transformations, precursors for organic electronics, and chemotherapeutic agents or chemical probes. Here, we provide a comprehensive review of the exploration of the current biological applications of Au complexes bearing phosphine donor ligands. The goal is to deepen our understanding of the synthetic utility and reactivity of Au-phosphine complexes to provide insights that could lead to the design of new molecules and enhance the cross-application or repurposing of these complexes.

Caspase-11 And Nlrp3 Exacerbate Systemic Klebsiella Infection Through Reducing Mitochondrial Ros Production, Yuqi Zhou, Zhuodong Chai, Ankit Pandeya, Ling Yang, Yan Zhang, Guoying Zhang, Congqing Wu, Zhenyu Li, Yinan Wei

Chemistry Faculty Publications

Introduction: Klebsiella pneumoniae is a Gram-negative bacterium and the third most commonly isolated microorganism in blood cultures from septic patients. Despite extensive research, the mechanisms underlying K. pneumoniae-induced sepsis and its pathogenesis remain unclear. Acute respiratory failure is a leading cause of mortality in systemic K. pneumoniae infections, highlighting the need to better understand the host immune response and bacterial clearance mechanisms. Method: To investigate the impact of K. pneumoniae infection on organ function and immune response, we utilized a systemic infection model through intraperitoneal injection in mice. Bacterial loads in key organs were quantified, and lung injury was assessed. …

Iodinated Disinfection Byproduct Formation From Iohexol In Sunlit And Chlorinated Urban Wastewaters, Reagan Patton Witt, Marcelo I. Guzman

Chemistry Faculty Publications

Iodinated disinfection by-products (I-DBPs) are of growing concern due to their elevated toxicity compared to their chlorinated counterparts, with links to adverse health effects such as bladder cancer and miscarriages. Medical imaging agents like iohexol, commonly used in healthcare facilities, introduce iodine into wastewater systems. This study investigates the photodegradation of iohexol and the subsequent formation of products, including I-DBPs, during simulated final wastewater treatment under chlorination and sunlight exposure. Experiments were conducted with solutions containing 30 μM iohexol, 3 mg L⁻¹ humic acids, and 5.5 mg L⁻¹ hypochlorite. Samples were irradiated at λ ≥ 295 nm and …

Improving Proteostasis Of Trafficking-Deficient GabaAReceptor Variants By Activating Ire1, Xu Fu, Ya Juan Wang, Kyung A. Lee, Lucie Y. Ahn, Xi Chen, Brock T. Harvey, Meng Wang, Hailey Seibert, Pei Pei Zhang, Adrian Guerrero, Ashleigh E. Schaffer, Christopher I. Richards, R. Luke Wiseman, Jeffery W. Kelly, Ting Wei Mu

Chemistry Faculty Publications

Gamma-aminobutyric acid type A receptors (GABA_ARs) are essential for maintaining the excitation–inhibition balance in the central nervous system. Genetic variations of GABA_ARs result in a variety of neurological disorders, such as epilepsy. A key pathogenic mechanism involves protein misfolding and defective assembly of GABA_ARs in the endoplasmic reticulum (ER), resulting in impaired surface expression and loss of function. Here, we investigated three trafficking-deficient variants of the GABA_AR α1 subunit (GABRA1), including D219N (ClinVar Variation ID: 127232), G251D (Variation ID: 419523), and P260L. We demonstrated that selective pharmacological activation of the IRE1/XBP1s signaling …

Machine Learning Approaches For Predicting Breast Cancer Recurrence: A Comparative Analysis, Noor Razzaq Abbas, Hussein Alkattan, Isam Bahaa Aldallal

Mesopotamian Journal of Artificial Intelligence in Healthcare

This paper reports a comparative analysis of four supervised machine learning algorithms: RF, SVM (using radial and linear kernels), Logistic Regression, and Multi-Layer Perceptron, for breast cancer recurrence prediction on a carefully curated clinical dataset. The data set, first collected by Royston and Altman and subsequently released on Kaggle, has patient age, menopausal status, tumor size, histological grade, lymph node status, estrogen and progesterone receptor levels, hormone therapy for treatment, recurrence-free survival time, and a binary recurrence outcome. The data set was then divided after the elimination of identifiers and z-score normalization in an 80:20 ratio using stratified sampling. Models …

Order Of The Coif Program, August 18, 2025, University Of South Carolina School Of Law Order Of The Coif

Order of the Coif Programs and Documents

No abstract provided.

Deep Learning Approaches For Predicting Strain Energy In Heterogeneous Materials, Junesh Gautam

Electronic Theses and Dissertations

Finite Element Analysis (FEA) faces computational challenges when analyzing nonlinear and heterogeneous materials. Utilizing the Mechanical MNIST dataset, comprising 60,000 simulated samples of 28x28 pixel domains under large deformation, the study evaluates classical regression methods (Linear Regression, Random Forest, Gradient Boosting) and advanced deep learning architectures (Convolutional Neural Networks (CNN) and Residual Networks (ResNet)). CNN models achieved superior performance, with a Mean Squared Error (MSE) of 4.21 and an R2 value of approximately 0.982, outperforming classical regression models and slightly surpassing ResNet architectures. These deep learning methods automatically learn spatial relationships from pixel-based representations, eliminating the need for manual feature …

Satellite And Uas Synergy For Large-Scale Crop Canopy Cover Mapping With Deep Learning, Muhammad Ali Irshad

Electronic Theses and Dissertations

No abstract provided.

Effects Of Essential Oils Alone Or In Combination With Monensin In An In Vitro Model Of Ruminal Acidosis, Jorge L. Bonilla Urbina

Electronic Theses and Dissertations

The objective of this study was to evaluate the effect of essential oils and/or monensin on the concentration of volatile fatty acids (VFA), ammonia, and pH in a ruminal acidosis in vitro model. Red Angus steers (n = 4; BW = 435 ± 9 kg) with ruminal and duodenal cannulas were allocated in a 4 × 4 Latin square design. Treatments were 1) Fed no essential oils (RB) or monensin sodium (MON:CON); 2) Fed RB at a rate of 14 g daily with no Mon (RB+); 3) Fed no RB and fed Mon at 400 mg daily (MON+); 4) Fed …

Don’T Do More With Less: Sustainable Work As A Management Value, Amanda Koziura

Library Faculty Research

Discusses a series of decisions a middle manager made to keep the work of her department sustainable and how she incorporated her values into her process.

The Legacy Of Dobbs: How The Supreme Court’S Decision To Review Gender- Affirming Care Bans Signals Its Intent To Eliminate The Protections Of Bostock And Obergefell Against Laws Designed To Discriminate Against Lgtbq+ Individuals, Jennifer S. Bard

Minnesota Journal of Law & Inequality

No abstract provided.

Poison! An Africana Legal Studies Investigation Into Enslaved Africans And Their Deadly Roots, Angi Porter

Minnesota Journal of Law & Inequality

No abstract provided.

All Set For Next Week: Reorienting Domesticity, Gendered Labor, And Collective Mourning, Kayla Lockwood

Graduate & Professional Student Association Research Forum

All Set for Next Week (2024) was a coffin‐shaped coffee table that formed the focal point of my Honey, I’m Home! Midway Exhibition—a core requirement for my advancement to candidacy, which I successfully completed. Revisiting the nostalgic domestic imagery of mid‐twentieth‐century sitcoms like The Honeymooners and I Love Lucy, this piece examined the precarious nature of home, shifts in gender roles, and the collective reshaping of mourning rituals during the COVID‐19 pandemic. Made from red oak, a wood historically linked to coffin‐making, the table evoked the memory of my grandfather’s passing while probing deeper questions surrounding inherited skill sets and …

Tax Education For Financial Empowerment, Job Buenrostro-Diaz

Second-Year Seminar Posters (COE 202)

Research Question: In what ways can understanding tax concepts help with financial literacy in improving money management decisions for lower income individuals?

This proposal outlines a strategy to increase quality education in middle to low income communities.