Digital Commons Network^™

Multiple Hypothesis Testing Under Dependence, Nabaneet Das

Doctoral Theses

We have examined various aspects of multiple hypothesis testing under dependence. Traditional algorithms designed to control the error arising from multiplicity become severely conservative when the hypotheses exhibit positive dependence, resulting in a loss of power. There is a paucity of literature explicating the behaviour of traditional algorithms when the hypotheses are dependent. In the realm of multiple testing, a popular multiplicity correction is the Bonferroni correction, which is perhaps the oldest classical approach for controlling the Family-Wise Error Rate (FWER) at a desired level, regardless of dependence among hypotheses. However, under the global null and equicorrelated normal model, the …

Sustainable Synthesis Of Cellulose-Derived Carbon Materials, Abbie S. Ganas

Sustainability Research & Practice Seminar Presentations

Dr. Abbie Ganas, Chemistry, presents "Sustainable Synthesis of Cellulose-Derived Carbon Materials".

Data Plan, Jennifer Jordan

Data Collection

The New Mexico Open Educational Resources (NMOER) Consortium was developed to improve student success and retention by supporting the use of course materials that are free to students. The following plan will gather data to demonstrate the need for this program, assess the impact of the program, and to further gather information about the use of free and open resources at NMOER Consortium schools.

Purdue Stars Performance Analysis, Kayla Gurganus, Lynne Dahmen

Institute for a Sustainable Future Documents

This Sustainability Performance Analysis (SPA) report reviews Purdue’s past and present sustainability performance as captured through STARS reporting to understand sustainability actions and to clearly and objectively identify where Purdue excels and how it might improve performance through the next STARS 3.0 submission.

Terminator: A Software Package For Fast And Local Optimization Of His-Tag Placement For Protein Affinity Purification, Rokas Gerulskis, Shelley D. Minteer

Chemistry Faculty Research & Creative Works

Although the use of affinity tags can greatly improve purification of expressed enzymes, the placement of affinity tags can significantly impact the expression, solubility, and function of recombinant proteins. To facilitate the optimal design of 6xHis-tagged constructs for protein purification, we developed Terminator, a Python-based software package, which takes a UniProt ID or existing protein sequence as input, identifies related sequences, maps sequence conservation retrieved from ConSurf onto protein 3D structures retrieved from the PDB and SWISS-MODEL, and analyzes proximity to cavities and functional sites to recommend the N- or C-terminus for placement of 6xHis fusion tags 86-100% accuracy in …

Navigating Trauma: A Linguistic Exploration Of Bilingual Trauma Expressions, Amira Mahmoud Othman

Theses and Dissertations

This study explores the relationship between language, trauma, and emotional expression among bilingual Arabic-English speakers, focusing on code-switching patterns and euphemisms, and more broadly the emotional roles of native and non-native languages in trauma narratives. Through qualitative interviews with 20 Egyptian participants, the research reveals that code-switching serves as both a linguistic and emotional tool, allowing speakers to navigate trauma by creating distance or engaging more intimately. Such codeswitching patterns include the integration of English content words within Arabic structures, morphosyntactic innovations, and gender agreement applications, reflecting the creative adaptability of bilingual speakers in emotionally charged contexts, in line with …

Enhancing Online Toxicity Detection On Gaming Networks: A Novel Embeddings-Based Valence Lexicon Approach, Heba Ismail, Ashraf Khalil, Ahmed Jasmy

All Works

Online toxicity and violent speech on gaming networks pose significant threats to societal well-being, particularly among adolescents, and are linked to severe consequences such as suicide. This highlights an urgent need for effective toxicity detection methods tailored to these platforms. Traditional rule-based approaches are inherently limited, and the performance of predictive models in detecting online toxicity is critically dependent on the quality and representativeness of their training data. However, the distinct linguistic characteristics of discourse on gaming networks present unique challenges in curating representative training samples using existing valence lexicons, often resulting in suboptimal detection accuracy. In this study, we …

Short-Run Economic Effects Of Michigan's State-Funded Preschool Programs, Timothy J. Bartik

Upjohn Institute Policy Papers

This policy paper estimates the short-run economic effects of the Great Start Readiness Program (GSRP), Michigan’s state-funded preschool program for 4-year-olds. The paper considers 15year effects on state residents’ per capita incomes due to impacts on employment rates and real wages, as well as cost-savings from free preschool and fiscal benefits due to tax base expansion. These 15-year effects ignore the program’s outcomes for child participants and focus on how the Michigan economy is affected by GSRP’s direct impacts on parents and preschool teachers. The estimates use a regional econometric model of a state’s economy, developed originally to evaluate economic …

Meet The Spring '25 Climate Action Clinic Cohort, Sustainability Institute

Sustainability Institute Blog

No abstract provided.

About: Project Coordinators, Partners, And Acknowledgements, University Of Mississippi Libraries. Archives And Special Collections

Books at Rowan Oak, Home of William Faulkner

No abstract provided.

Unh Research Team Finds Concentrated Pfas In Watershed Foams, Robbin Ray

UNH Today Archive

No abstract provided.

2025-02-19 Seattle U Students Survive Another Quarter Of Midterms, Dylan Berman

The Spectator Online

No abstract provided.

The Bg News February 19, 2025, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. February 19, 2025. Volume 104-Issue 18.

Therapy Combining Sorafenib And Natural Killer Cells For Hepatocellular Carcinoma: Insights From Magnetic Resonance Imaging And Histological Analyses, Zigeng Zhang, Guangbo Yu, Aydin Eresen, Qiaoming Hou, Sha Webster, Farideh Amirrad, Surya M. Nauli, Zhuoli Zhang

Pharmacy Faculty Articles and Research

Background/Objectives: Hepatocellular carcinoma (HCC) remains a significant global health issue due to its high mortality rate and resistance to standard treatments. Sorafenib, the first-line systemic therapy for unresectable HCC, shows limited effectiveness due to resistance and severe side effects. Recent studies suggest that combining sorafenib with immunotherapy, particularly natural killer (NK) cells, may improve treatment outcomes. Methods: This study examined the effectiveness of sorafenib combined with NK cells pretreated with interleukin-12 (IL-12) and interleukin-18 (IL-18) in a rat HCC model. Tumor progression and treatment outcomes were assessed using MRI and histological analysis. Results: The results show that …

Trem2 Promotes Lung Fibrosis Via Controlling Alveolar Macrophage Survival And Pro-Fibrotic Activity, Huachun Cui, Sami Banerjee, Na Xie, Musaddique Hussain, Ashish Jaiswal, Hongli Liu, Tejaswini Kulkarni, Veena B Antony, Rui-Ming Liu, Marco Colonna, Gang Liu

2020-Current year OA Pubs

Lung macrophages play a pivotal role in pulmonary fibrosis, with monocyte-derived alveolar macrophages driving disease progression. However, the mechanisms regulating their pro-fibrotic behavior and survival remain unclear, and effective therapeutic strategies are lacking. Here we show that triggering receptors expressed on myeloid cells 2 are predominantly expressed on monocyte-derived alveolar macrophages in fibrotic mouse lungs and are significantly elevated in lung macrophages from patients with idiopathic pulmonary fibrosis. Deletion or knockdown of this receptor disrupts intracellular survival signaling, promotes macrophage apoptosis, and attenuates their pro-fibrotic phenotype. We further demonstrate that a lipid mediator and a high-avidity ligand of this receptor, …

Targeting Fatty Acid Synthase Reduces Aortic Atherosclerosis And Inflammation, Rodrigo Meade, Dina Ibrahim, Connor Engel, Larisa Belaygorod, Batool Arif, Fong-Fu Hsu, Sangeeta Adak, Ryan Catlett, Mingzhou Zhou, Ma Xenia G Ilagan, Clay F Semenkovich, Mohamed A Zayed

2020-Current year OA Pubs

Fatty acid synthase (FAS) is predominantly expressed in the liver and adipose tissue. It plays vital roles in de novo synthesis of saturated fatty acids and regulates insulin sensitivity. We previously demonstrated that serum circulating FAS (cFAS) is a clinical biomarker for advanced atherosclerosis, and that it is conjugated to low-density lipoproteins (LDL). However, it remains unknown whether cFAS can directly impact atheroprogression. To investigate this, we evaluate whether cFAS impacts macrophage foam cell formation - an important cellular process leading to atheroprogression. Macrophages exposed to human serum containing high levels of cFAS show increased foam cell formation as compared …

Breastfeeding Interventions And Programs Conducted In The Islamic Republic Of Iran: A Scoping Review, Patricia J. Kelly, Amrita Sidhu, Anusha Sajja, Devanshi Majeethia, Elizabeth Dodge, Basil H. Aboul-Enein

College of Nursing Faculty Papers & Presentations

The purpose of this review was to identify interventions promoting breastfeeding (BF), BF practices and their outcomes in Iran. Using the PRISMA-ScR Guidelines, we searched across 14 databases for publications published between 2010 and February 2024 to identify studies published in English or Farsi language in peer-reviewed journals, using search terms 'breastfeeding', 'lactation', 'education', 'promotion', 'intervention' and 'program'. Inclusion criteria included intervention-based studies with quantitative outcomes of pregnant women/mothers receiving education, training or other intervention that promoted BF or exclusive BF. Excluded studies were protocols, those examining Iranian communities outside of Iran publications in other languages, brief communications, gray literature …

Escape From Diabetes, J E. Jochum, J Carmack, J Toon

Clinical Practice in Athletic Training

Introduction: In the past decade, interprofessional education (IPE) to promote interprofessional collaborative practice has become an integral component of pre-licensure education in the health professions. Research shows that IPE activities involving problem-solving in patient care that requires cooperation and communication among the professions is most effective. An effective activity to meet interprofessional competencies is the use of escape rooms. Escape rooms are team-based games where groups of individuals solve puzzles to accomplish a specific goal, typically in a limited amount of time. There are many benefits to using escape rooms in education, including promoting problem-solving, teamwork, and creativity, improving focus …

Modification Of Ergonomics For A World-Class Brass Instrumentalist With A Congenital Limb Difference: Level 3 Case, O G. Newhouse

Clinical Practice in Athletic Training

Background: A drum and bugle corps is a musical marching organization that consists of approximately 160 brass, percussion, and color guard performers. There are currently twenty-one drum corps organizations at the world-class level that compete. Organizations learn their 8–10-minute show in the late spring and begin traveling the country performing and competing in the early summer until August. Rehearsal days can be up to 10 hours of practice including visual and music. It has been reported that the incidence of upper limb pain is higher in those who have longer practice times, in which is a symptom of overuse. These …

Assessing The Contribution Of Rare Protein-Coding Germline Variants To Prostate Cancer Risk And Severity In 37,184 Cases, Konrad H Stopsack, Vijai Joseph, Oliver S Burren, Ryan S Dhindsa, Abhishek Nag, Jacob E Berchuck, Amanda O'Neill, Ali Abbasi, Anthony W Zoghbi, Jesus Alegre-Díaz, Pablo Kuri-Morales, Jaime Berumen, Roberto Tapia-Conyer, Jonathan Emberson, Jason M Torres, Rory Collins, Quanli Wang, David Goldstein, Athena Matakidou, Carolina Haefliger, Lauren Anderson-Dring, Ruth March, Vaidehi Jobanputra, Brian Dougherty, Keren Carss, Slavé Petrovski, Philip W Kantoff, Kenneth Offit, Lorelei A Mucci, Mark Pomerantz, Margarete A Fabre

Faculty, Staff and Students Publications

To assess the contribution of rare coding germline genetic variants to prostate cancer risk and severity, we perform here a meta-analysis of 37,184 prostate cancer cases and 331,329 male controls from five cohorts with germline whole exome or genome sequencing data, and one cohort with imputed array data. At the gene level, our case-control collapsing analysis confirms associations between rare damaging variants in four genes and increased prostate cancer risk: SAMHD1, BRCA2 and ATM at the study-wide significance level (P <  1×10−8), and CHEK2 at the suggestive threshold (P <  2.6×10−6). Our case-only analysis, reveals that rare damaging variants in AOX1 are associated with more aggressive disease (OR = 2.60 [1.75–3.83], …

Clinician Experiences With Ambient Scribe Technology To Assist With Documentation Burden And Efficiency, Matthew J. Duggan, Julietta Gervase, Anna Schoenbaum, William Hanson, John T. Howell, Michael Sheinberg, Kevin B. Johnson

SKMC Student Presentations and Publications

IMPORTANCE: Timely evaluation of ambient scribing technology is warranted to assess whether this technology can lessen the burden of clinical documentation on clinicians.

OBJECTIVE: To investigate the association of ambient scribing technology with efficiency, quality, and perceived burden of clinical documentation in the outpatient setting.

DESIGN, SETTING, AND PARTICIPANTS: This prospective, single-group pre-post quality improvement study was conducted between April and June 2024 in the outpatient setting of an academic health system in Philadelphia, Pennsylvania. Participants included physicians, nurse practitioners, and physician assistants. Data were analyzed from July to August 2024.

EXPOSURE: Access to an artificial intelligence-driven ambient scribing tool …

Correlation Of Gnas Mutational Status With Oncologic Outcomes In Patients With Resected Intraductal Papillary Mucinous Neoplasms, Julia S. Evans, Kylee Shivok, Hui Hsuan Chen, Eliyahu Gorgov, Wilbur Bowne, Aditi Jain, Phd, Harish Lavu, Charles J. Yeo, Avinoam Nevler

SKMC Student Presentations and Publications

Background: Intraductal papillary mucinous neoplasms (IPMNs) are pre-malignant pancreatic lesions that may progress to invasive pancreatic ductal adenocarcinoma (PDAC). IPMN-associated invasive carcinoma (iIPMN) has been associated with more favorable survival outcomes compared to non-iIPMN-derived PDAC. Here, we aim to investigate the genetic landscape of IPMNs to assess their relevance to oncologic outcomes. Methods: This retrospective study used a large single-institution prospectively maintained database. Patients who underwent curative-intent pancreatic resection between 2016 and 2022 with histologically confirmed diagnosis of IPMN were included. Demographic, pathologic, molecular, and oncologic outcome data were recorded. Kaplan–Meier survival analyses were performed. PDAC data from public genetic …

Investigating Comorbidities And Heritability Of Chronic Intractable Migraine With Reactive Hypoglycemia, Stella Santa Ana, Alexander Baumann, Benjamin Gordon, Alex Schofield, Sophia Delgado, Catherine Yvonne Russell, Jacob Warner, Christina Nelson, John A. Kriak, Kyle B. Bills, David W. Sant

Annual Research Symposium

Poster at 2025 Roseman Research Symposium

Dental Phobia And Oral Health: Assessing Its Impact On Quality Of Life, Mahak Sargodhia, Kamran H. Awan

Annual Research Symposium

No abstract provided.

Spartan Daily, February 19, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 164, Issue 12

To Enhance Sustainable Development Goal Research, Open Up Commercial Satellite Image Archives, Philippe Rufin, Patrick Meyfroidt, Felicia O. Akinyemi, Lyndon Estes, Esther Shupei Ibrahim, Meha Jain, Hannah Kerner, Sá Nogueira Lisboa, David Lobell, Catherine Nakalembe, Claudio Persello, Michelle C.A. Picoli, Natasha Ribeiro, Almeida Alberto Sitoe, Katharina Waha, Sherrie Wang

Geography

Observing the Earth with satellites offers clear advantages when it comes to tracking the health of the planet—consistent measurements that can be translated into environmentally relevant estimates, such as carbon, crop productivity, or land use. The resulting information covers large regions, irrespective of administrative boundaries. These measurements also drastically reduce costs compared with on-the-ground data collection efforts. Earth observation (EO) data thereby efficiently deliver timely insights that can directly inform sustainability debates, including with regard to United Nations (UN) Sustainable Development Goals (SDGs). At the heart of these efforts are open data initiatives linked to the public release of medium- …

The Effects Of A Joint Reduction Trainer On Confidence Levels In Professional Athletic Training Students, T Franklin, S Hacherl

Clinical Practice in Athletic Training

Introduction: Dislocations are common injuries managed by athletic trainers, yet athletic training students are unlikely to practice reduction techniques during clinical experiences. Current standards set by the Commission on Accreditation of Athletic Training Education require accredited programs to prepare students to manage patients with dislocations, including joint reductions. Research indicates the use of simulation techniques, such as joint reduction simulators, in education can fill clinical experience gaps and improve student confidence and skills. Shoulder dislocations make up nearly 50% of dislocations with several reduction techniques identified in the current literature. The use of a joint reduction simulator may provide athletic …

Barriers To The Implementation Of The Amsterdam 2022 Statement In The Secondary School Setting, L Torres, J L. Baldari, F A. Gardin, A M. Price

Clinical Practice in Athletic Training

Introduction: The Amsterdam 2022 International Consensus Statement on Concussion in Sport provides a summary of contemporary best practice recommendations for healthcare providers who are involved in the care of athletes at risk of sport-related concussion (SRC). Given that athletic trainers (ATs) have a professional responsibility to continually educate themselves on topics of great importance to the population that they care for, such as SRC management, it is reasonable to expect them to evolve their concussion management protocols to better align themselves with the recommendations found this statement. The purpose of this study was to identify the barriers associated with the …

Using Ai-Generated Scenarios To Enhance Learning Of The Emergency Assessment Process, D Cobble, L Schroeder, J Vaughn, S Ford

Clinical Practice in Athletic Training

Introduction: Rigorous accreditation standards require students to demonstrate competency in various clinical proficiencies through clinical practice or simulation-based educational activities. Therefore, simulation has become an integral component of athletic training education, as scenarios can provide realistic and reproducible experiences for all students. To that end, our study had two primary objectives: investigate the ability of artificial intelligence (AI) to generate accurate and realistic athletic training simulation scenarios and evaluate AI's effectiveness in teaching and reinforcing the emergency assessment process through student-created scenarios. Methods: Phase one, AI developed three different scenarios for patients experiencing (1) an ovarian cyst, (2) a hypoglycemic …

Athletic Trainer Compensation Characteristics, J P. Young, K Ef Mair, L E. Eberman

Clinical Practice in Athletic Training

Introduction: Athletic trainers (ATs) are integral to healthcare yet face ongoing challenges that affect job satisfaction and retention. Factors such as long work hours, low pay, and work-family conflict contribute to dissatisfaction and a desire to leave the profession. Salary disparities and lack of administrative support are key factors impacting professional fulfillment and career longevity. Identifying how compensation influences job satisfaction is essential for improving retention and advancing the profession. Our study aimed to examine the compensation characteristics of ATs and determine the key factors that predict gross income. Methods: A cross-sectional, web-based survey was conducted. The survey was validated …