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Beyond The Bell Curve: Understanding Native American Academic Placements, Sarah-Margaret Clark Jun 2026

Beyond The Bell Curve: Understanding Native American Academic Placements, Sarah-Margaret Clark

Theses and Dissertations

This study examined biases regarding the referrals that teachers make regarding student placement recommendations for Native American students. Special education teachers (n = 97) from around the United States completed a digital card sort task involving 24 fictitious student record cards. The student record cards contained subtle information about the ethnicity of the student, as indicated through the use of racial identification (Native American, Asian, or White) on the student records and the use of student names that may be associated with these three categories. Academic information was equal among each of these three groups. Each group contained identical male …

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Calibration And Validation Of An Ogden Material Model For Thermoplastic Polyurethane In 3d-Printed Tensegrity Structures, Caleb C. Swain Jun 2026

Calibration And Validation Of An Ogden Material Model For Thermoplastic Polyurethane In 3d-Printed Tensegrity Structures, Caleb C. Swain

Theses and Dissertations

This work is motivated by ongoing efforts within the Smart Materials, Adaptronics, and Shock Laboratory (SMASH Lab) at Brigham Young University (BYU) to develop variable-stiffness, external fixators using 3D-printed tensegrity structures. In the process of designing and evaluating these systems, the need arose to accurately model the nonlinear mechanical behavior of thermoplastic polyurethane (TPU), the primary material used in prototype fabrication. This thesis investigates how accurately a calibrated Ogden material model can predict the nonlinear mechanical response of TPU in 3D-printed tensegrity structures. Experimental data were used to calibrate the parameters of the hyperelastic constitutive model through nonlinear optimization. An …

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Open Data From Ligo, Virgo, And Kagra Through The First Part Of The Fourth Observing Run, A. G. Abac, I. Abouelfettouh, Teviet Creighton, Mario C. Diaz, Raul Alberto Espinosa Perez, J. Lawrence, Francisco Llamas Villarreal, Soma Mukherjee, Volker Quetschke, Miriam Ramos Arevalo, Wenhui Wang Jun 2026

Open Data From Ligo, Virgo, And Kagra Through The First Part Of The Fourth Observing Run, A. G. Abac, I. Abouelfettouh, Teviet Creighton, Mario C. Diaz, Raul Alberto Espinosa Perez, J. Lawrence, Francisco Llamas Villarreal, Soma Mukherjee, Volker Quetschke, Miriam Ramos Arevalo, Wenhui Wang

Physics & Astronomy Faculty Publications

LIGO, Virgo, and KAGRA form a network of gravitational-wave observatories. Data and analysis results from this network are made publicly available through the Gravitational Wave Open Science Center. This paper describes open data from this network, including the addition of data from the first part of the fourth observing run and selected periods from the preceding engineering run, collected from 2023 May to 2024 January. The public dataset includes calibrated strain time series for each instrument, data from additional channels used for noise subtraction and detector characterization, and analysis data products from version 4.0 of the Gravitational-Wave Transient Catalog.

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Searches For Continuous Gravitational Waves From Supernova Remnants In The First Part Of The Ligo-Virgo-Kagra Fourth Observing Run, A. G. Abac, I. Abouelfettouh, Teviet Creighton, Mario C. Diaz, Raul Alberto Espinosa Perez, J. Lawrence, Francisco Llamas Villarreal, Soma Mukherjee, Volker Quetschke, Miriam Ramos Arevalo, Wenhui Wang Jun 2026

Searches For Continuous Gravitational Waves From Supernova Remnants In The First Part Of The Ligo-Virgo-Kagra Fourth Observing Run, A. G. Abac, I. Abouelfettouh, Teviet Creighton, Mario C. Diaz, Raul Alberto Espinosa Perez, J. Lawrence, Francisco Llamas Villarreal, Soma Mukherjee, Volker Quetschke, Miriam Ramos Arevalo, Wenhui Wang

Physics & Astronomy Faculty Publications

We present results from directed searches for continuous gravitational waves from a sample of 15 nearby supernova remnants, likely hosting young neutron star candidates, using data from the first eight months of the fourth observing run (O4) of the LIGO–Virgo–KAGRA Collaboration. The analysis employs five pipelines: four semicoherent methods—the Band-Sampled-Data directed pipeline, Weave, and two Viterbi pipelines (single- and dual-harmonic)—and PyStoch, a cross-correlation-based pipeline. These searches cover wide frequency bands and do not assume prior knowledge of the targets’ ephemerides. No evidence of a signal is found from any of the 15 sources. We set 95% confidence-level upper limits on …

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Gw230814: Investigation Of A Loud Gravitational-Wave Signal Observed With A Single Detector, A. G. Abac, I. Abouelfettouh, Teviet Creighton, Mario C. Diaz, Raul Alberto Espinosa Perez, J. Lawrence, Francisco Llamas Villarreal, Soma Mukherjee, Volker Quetschke, Miriam Ramos Arevalo, Wenhui Wang Jun 2026

Gw230814: Investigation Of A Loud Gravitational-Wave Signal Observed With A Single Detector, A. G. Abac, I. Abouelfettouh, Teviet Creighton, Mario C. Diaz, Raul Alberto Espinosa Perez, J. Lawrence, Francisco Llamas Villarreal, Soma Mukherjee, Volker Quetschke, Miriam Ramos Arevalo, Wenhui Wang

Physics & Astronomy Faculty Publications

GW230814, detected by the LIGO Livingston observatory with a signal-to-noise ratio of 42.4, represents the loudest gravitational-wave signal in the GWTC-4.0 catalog. Its source is consistent with a binary black hole coalescence with component masses m1=33.7+2.9−2.2M⊙, m2=29.9+2.1−2.8M⊙, and a small effective inspiral spin χeff=−0.01+0.06−0.07. The high signal-to-noise ratio enabled us to detect an ℓ = ∣m∣ = 4 mode in the inspiral–merger–ringdown signal for the first time (with Bayes factor ≈10), as well as enabling a range of tests of consistency between theoretical predictions and the observed waveform. While most of these tests show agreement with theoretical predictions, there are …

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An Access-Control Logic In Hol (Trindemossen 2), Shiu-Kai Chin Jun 2026

An Access-Control Logic In Hol (Trindemossen 2), Shiu-Kai Chin

Electrical Engineering and Computer Science - All Scholarship

This manual documents the embedding of an access-control logic (ACL) — as presented in the textbook Access Control, Security, and Trust: A Logical Approach (Chin and Older, 2011) — within the Cambridge Higher-Order Logic theorem prover HOL-4. The logic is a multi-agent modal logic with Kripke semantics. Its purpose is to reason about authentication, authorization, integrity, security, and trust. The inference rules of the ACL are proved to be sound. The inference rules are a command-and-control (C2) calculus. The value of the ACL is its support for rigorous, verified, and trustworthy policies for complete mediation, i.e., where all actions are …

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From Unfinished Sentences To Unfinished Degrees: A Reflection On Students’ Struggles With Academic Writing In The Context Of Retention In Higher Institutes Of Education, Irina Ruppo Jun 2026

From Unfinished Sentences To Unfinished Degrees: A Reflection On Students’ Struggles With Academic Writing In The Context Of Retention In Higher Institutes Of Education, Irina Ruppo

Irish Journal of Academic Practice

This article explores the experiences and beliefs of students whose struggles with academic writing had led to contemplation of withdrawal from the university. It proposes that the absence of writing as a separate factor in existing retention models obscures the importance of writing issues to students’ persistence with their chosen course of study. Through a qualitative analysis of in-depth interviews with undergraduate students, the article suggests that students’ struggles with writing may be distinct from their overall difficulties with the workload. Four beliefs about academic writing are identified as potentially contributing to the students’ malintegrative experience within the institution. Seeing …

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Gwtc-4.0: Updating The Gravitational-Wave Transient Catalog With Observations From The First Part Of The Fourth Ligo–Virgo–Kagra Observing Run, A. G. Abac, I. Abouelfettouh, Teviet Creighton, Mario C. Diaz, Raul Alberto Espinosa Perez, J. Lawrence, Francisco Llamas Villarreal, Soma Mukherjee, Volker Quetschke, Miriam Ramos Arevalo, Wenhui Wang Jun 2026

Gwtc-4.0: Updating The Gravitational-Wave Transient Catalog With Observations From The First Part Of The Fourth Ligo–Virgo–Kagra Observing Run, A. G. Abac, I. Abouelfettouh, Teviet Creighton, Mario C. Diaz, Raul Alberto Espinosa Perez, J. Lawrence, Francisco Llamas Villarreal, Soma Mukherjee, Volker Quetschke, Miriam Ramos Arevalo, Wenhui Wang

Physics & Astronomy Faculty Publications

Version 4.0 of the Gravitational-Wave Transient Catalog (GWTC-4.0) adds new candidates detected by the LIGO, Virgo, and KAGRA observatories through the first part of the fourth observing run (O4a: 2023 May 24 15:00:00 to 2024 January 16 16:00:00 UTC) and a preceding engineering run. In these new data, we find 128 compact binary coalescence candidates that are identified by at least one of our search algorithms with a probability of astrophysical origin pastro ≥ 0.5 and that are not vetoed during event validation. We also provide detailed source property measurements for 86 of these that have a false-alarm rate …

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Quality Improvement Project: The Impact Of A Safety Coach Program In A Pediatric Intensive Care Unit, Royanne Lickliter Jun 2026

Quality Improvement Project: The Impact Of A Safety Coach Program In A Pediatric Intensive Care Unit, Royanne Lickliter

Doctor of Nursing Practice Projects

Patient safety remains a critical concern in healthcare, with hospital-acquired conditions (HACs) contributing to preventable harm, mortality, and increased costs, particularly in high-acuity settings such as Pediatric intensive care units (PICUs). A recent safety culture survey at a tertiary pediatric hospital identified gaps in proactive safety behaviors, communication, and psychological safety. The primary problem identified was inconsistent engagement in proactive safety practices and limited frontline empowerment to identify and mitigate risks in real time. The purpose of this quality improvement (QI) project was to evaluate the impact of implementing a structured Safety Coach Program in the PICU on HAC rates, …

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Application Of Multi-Criteria Decision Analysis In Pharmacy And Therapeutics Committee Formulary Decision-Making: A Systematic Review And Proof-Of-Concept Framework, Georges Adunlin, Riley Atkinson Jun 2026

Application Of Multi-Criteria Decision Analysis In Pharmacy And Therapeutics Committee Formulary Decision-Making: A Systematic Review And Proof-Of-Concept Framework, Georges Adunlin, Riley Atkinson

Posters

Background: Pharmacy and therapeutics (P&T) committees must evaluate competing medications within the constraints of finite healthcare resources. Traditional formulary decision-making processes may inadequately capture the multidimensional value of medications. Multi-criteria decision analysis (MCDA) has emerged as a structured approach to incorporate clinical, economic, and operational considerations; however, evidence of its real-world application in P&T committee decision-making remains limited.   Objectives: (1) To systematically review and synthesize published literature describing the use of MCDA in formulary decision-making by P&T committees. (2) To develop a conceptual MCDA framework and demonstrate its feasibility through a proof-of-concept application within a P&T committee context.   Methods: A …

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Multilevel Drivers Of Missed Opportunities For Hiv Prevention: A Qualitative Synthesis Within A Systematic Review, Ismaeel Yunusa, Tarilate Temedie-Asogwa, Osaro Mgbere, Julie Atta, Moosa Tatar, Susan Abughosh, Ekere Essien Jun 2026

Multilevel Drivers Of Missed Opportunities For Hiv Prevention: A Qualitative Synthesis Within A Systematic Review, Ismaeel Yunusa, Tarilate Temedie-Asogwa, Osaro Mgbere, Julie Atta, Moosa Tatar, Susan Abughosh, Ekere Essien

Posters

Background: Despite the availability of effective HIV prevention strategies, including pre-exposure prophylaxis (PrEP), gaps in prevention delivery persist across healthcare settings. Missed opportunities for HIV prevention remain common, yet multilevel factors driving these gaps are not fully understood. Understanding these drivers is essential to inform effective interventions at the individual, interpersonal, provider, and system levels. Objectives: To identify and synthesize multilevel determinants of missed opportunities for HIV prevention and PrEP delivery. Methods: We conducted a qualitative synthesis within a systematic review of U.S.-based studies (2012-2025) on missed opportunities for HIV prevention. Articles were identified through database searches (PubMed, Embase, and …

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Regulation In Real Time: A Mixed-Methods Study Of Pharmd Student Learning At A Live Board Of Pharmacy Meeting, Keerthana R. Iyer, Taylor Gannon, Lindsey M. Rayborn, Joseph A. Dikun Jun 2026

Regulation In Real Time: A Mixed-Methods Study Of Pharmd Student Learning At A Live Board Of Pharmacy Meeting, Keerthana R. Iyer, Taylor Gannon, Lindsey M. Rayborn, Joseph A. Dikun

Posters

Background: Pharmacists practice within complex legal, regulatory, and ethical frameworks; however, PharmD curricula often offer limited direct exposure to regulatory decision-making in authentic practice settings. Observation of a live Board of Pharmacy meeting may enhance students understanding of professional accountability, systems-level oversight, and the regulatory context of pharmacy practice. Objective: To examine changes in first-year PharmD students perceived regulatory understanding, ethical reasoning, perceptions of professional roles, and advocacy-related beliefs following attendance at a live Mississippi Board of Pharmacy meeting. Methods: This exploratory mixed-methods study included first-year PharmD students enrolled in a required course at the University of Mississippi. Students attended …

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Healthcare Expenditures Associated With Cardiovascular-Kidney-Metabolic (Ckm) Syndrome Stages Among United States Adults, Ziqi Guo, Kaustuv Bhattacharya Jun 2026

Healthcare Expenditures Associated With Cardiovascular-Kidney-Metabolic (Ckm) Syndrome Stages Among United States Adults, Ziqi Guo, Kaustuv Bhattacharya

Posters

OBJECTIVES: To estimate healthcare expenditures associated with each CKM syndrome stage and to quantify incremental expenditures for each stage compared to stage 0. METHODS: A retrospective cross-sectional study was conducted using pooled data from adults (18 years) in the 2018, 2020 and 2022 Medical Expenditure Panel Survey (MEPS). CKM syndrome stages were defined based on the American Heart Association (AHA) staging construct using International Classification of Diseases, Tenth Revision (ICD-10). Adjusted mean healthcare expenditures for each CKM syndrome stage and incremental expenditures relative to stage 0 were estimated using survey-weighted two part generalized linear models. 95% confidence interval (CI) was …

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Motivational Interviewing Impact On Outcomes Is Affected By Level Of Interventionist Training: A Review Of Systematic Reviews, Sneha Gaonkar, Jan Kavookjian, Heqin Yang Jun 2026

Motivational Interviewing Impact On Outcomes Is Affected By Level Of Interventionist Training: A Review Of Systematic Reviews, Sneha Gaonkar, Jan Kavookjian, Heqin Yang

Podiums

ackground: Motivational Interviewing (MI) involves interviewing a person in an autonomy-supporting, person-centered, encouraging way, eliciting the individuals internal change motivations. Thirteen modified Cochrane method (MCM) systematic reviews of MI impact on outcomes included varied populations, interventionist types, and target outcomes with a lens for whether MI training of interventionists was reported and/or met evidence-based MI training guidelines. The objective of this study was to review MI training reported in 126 retained articles across MCM MI reviews and describe level of evidence-based MI training reported. Methods: Each MCM review, published between 2012 to present, aimed to explore and report evidence and …

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Examining Social Determinants And Lifestyle Factors In Persons With Interstitial Lung Diseases And Gastroesophageal Reflux Disease, Arindam Saha, Surachat Ngorsuraches Jun 2026

Examining Social Determinants And Lifestyle Factors In Persons With Interstitial Lung Diseases And Gastroesophageal Reflux Disease, Arindam Saha, Surachat Ngorsuraches

Posters

Background: Interstitial Lung Disease (ILD) is a group of heterogeneous chronic pulmonary disorders associated with substantial morbidity and mortality. Gastroesophageal reflux disease (GERD) is a common comorbidity among ILD patients and has been associated with disease burden and progression. While prior studies have focused on demographic and clinical characteristics, social determinants of health (SDOH) and lifestyle factors remain underexplored.   Objective: To examine SDOH and lifestyle-related factors among individuals with ILD and GERD.   Methods: A cross-sectional study was conducted among 4,372 ILD patients from the All of Us Research Program cohort. A multivariate logistic regression was used to assess age, sex, …

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Artificial Intelligence–Driven Paradigm Transformation In Biopharmaceutical R&D: Applications And Emerging Scenarios, Lili Liu, Mingyue Zheng, Ye Yuan, Xutong Li, Rong Fan, Wei Wei, Jinxin Zhao, Guobin Qi, Hua Yue, Likun Gong, Songping Zhang, Jiachen Li, Yuchen Sun, Xiaoyan Chen, Yao Chen, Xin Liu, Xiao Zhang, Yuehong Gao, Jianfeng Li, Kaixian Chen, Guanghui Ma, Jianmin Yue Jun 2026

Artificial Intelligence–Driven Paradigm Transformation In Biopharmaceutical R&D: Applications And Emerging Scenarios, Lili Liu, Mingyue Zheng, Ye Yuan, Xutong Li, Rong Fan, Wei Wei, Jinxin Zhao, Guobin Qi, Hua Yue, Likun Gong, Songping Zhang, Jiachen Li, Yuchen Sun, Xiaoyan Chen, Yao Chen, Xin Liu, Xiao Zhang, Yuehong Gao, Jianfeng Li, Kaixian Chen, Guanghui Ma, Jianmin Yue

Bulletin of Chinese Academy of Sciences (Chinese Version)

The biopharmaceutical industry is a critical domain underpinning national scientific and technological innovation development and public health. With the rapid advancement of artificial intelligence (AI) and its deep integration with the life sciences, biomedicine research is undergoing a paradigm shift from traditional experience-driven trial-and-error approaches to data-driven and predictive validation-based models. This study systematically examines the pathways for reshaping research in biomedicine paradigms under the convergence of data-driven, mechanism-driven, and intelligence-driven approaches. It focuses on recent advances in the application of AI across key stages, including drug discovery and design, druggability evaluation, delivery system design and optimization, nonclinical and clinical …

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Artificial Intelligence Empowering Remote Sensing: Challenges, Paradigms And Strategic Layout, Jiayuan Shen, Peirui Cheng, Zhirui Wang, Wei Liang, Xian Sun, Yirong Wu Jun 2026

Artificial Intelligence Empowering Remote Sensing: Challenges, Paradigms And Strategic Layout, Jiayuan Shen, Peirui Cheng, Zhirui Wang, Wei Liang, Xian Sun, Yirong Wu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Remote sensing science and technology, as a key discipline for Earth observation and global change research, faces systemic challenges in processing massive multi-source data, accurately extracting complex information, and delivering high-timeliness application services. The rapid advances in artificial intelligence (AI) provide a new opportunity to address the deep-seated dilemma in remote sensing of being “data-rich but insufficient in effective information mining”. Guided by a problem-oriented approach, this study first systematically analyzes the core challenges facing the development of remote sensing across four dimensions: data understanding, technical methods, scientific mechanisms, and application ecosystems. It then reviews the technical evolution of AI-empowered …

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Artificial Intelligence For Science: Connotations, Characteristics, And System, Kaihua Chen, Heyang Li, Hongxin Liu, Binbin Zhao, Shuo Yang Jun 2026

Artificial Intelligence For Science: Connotations, Characteristics, And System, Kaihua Chen, Heyang Li, Hongxin Liu, Binbin Zhao, Shuo Yang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Artificial intelligence is profoundly transforming the fundamental nature of scientific research, reshaping its modes of knowledge production and organizational operation, driving the emergence of a new artificial intelligence for science (AI4S) research paradigm, and accelerating full-chain innovation paradigm transformation. This study defines the basic connotations of AI4S across three dimensions, namely, enabling applications, tools and methods, and epistemic knowledge, and systematically identifies five core characteristics: human-machine symbiosis, autonomous evolution, interdisciplinary integration, resource intensity, and open ecosystems. It further constructs a supporting system and operational architecture encompassing layers of infrastructure, data resources, model tools, task execution, and application scenarios. Building on …

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Building Basic Research Ecosystem To Consolidate Foundation Of Strong Nation, Xin Fang, Ke Wen Jun 2026

Building Basic Research Ecosystem To Consolidate Foundation Of Strong Nation, Xin Fang, Ke Wen

Bulletin of Chinese Academy of Sciences (Chinese Version)

Basic research is the source of the entire scientific system and the master switch for all technological problems. This study systematically reviews the evolution of the connotation and functions of basic research, and explores the new characteristics of basic research development triggered by the paradigm shift of AI for Science (AI4S): the shift of activity subjects from human‑dominated to human‑machine collaboration, the comprehensive restructuring of organizational models, the increasingly prominent strategic value of public intelligent research infrastructure, and the growing urgency to coordinate security and governance institution building. Addressing the demands of the new era, the study proposes principles and …

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Optimizing Institution Of Demand-Oriented Basic Research, Promoting Deep Integration Of Technological Innovation And Industrial Innovation, Wei Lyu Jun 2026

Optimizing Institution Of Demand-Oriented Basic Research, Promoting Deep Integration Of Technological Innovation And Industrial Innovation, Wei Lyu

Bulletin of Chinese Academy of Sciences (Chinese Version)

From both theoretical and domestic and international practical perspectives, this study analyzes the connotation and classification of demand-oriented basic research. It examines the expenditure structure, main pathways, and major existing problems of demand-oriented basic research in China. Based on three levels—strategically guided systematic basic research, frontier-guided exploratory basic research, and market-oriented applied basic research—it categorizes and studies the funding mechanisms and organizational models of demand-oriented basic research in combination with practice, and provides relevant suggestions for improving the quality enhancement mechanisms of demand-oriented basic research.

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Logic And Path Of Transformation Reform Between Old And New Research Evaluation Models, Fang Xu, Xiaoxuan Li Jun 2026

Logic And Path Of Transformation Reform Between Old And New Research Evaluation Models, Fang Xu, Xiaoxuan Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

The national 15th Five-Year Plan once again emphasizes breaking the four-only criteria. Why is it so difficult to dismantle the four-only criteria? This study argues that an in-depth analysis of the underlying logical relationship between the old label-based evaluation model and the new connotation-oriented quality evaluation model is required to address this question. The study finds that the label-based evaluation model is a rational choice under specific historical circumstances and it has delivered positive effects. During the transition toward connotation-oriented quality evaluation, problems concerning indicators such as academic papers have been well resolved. Nevertheless, national science and technology awards and …

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Upholding Long-Termism In Basic Research To Shape Leading Advantage Of Automotive Industry, Yubo Lian Jun 2026

Upholding Long-Termism In Basic Research To Shape Leading Advantage Of Automotive Industry, Yubo Lian

Bulletin of Chinese Academy of Sciences (Chinese Version)

General Secretary Xi Jinping has pointed out that basic research is the origin of the entire scientific system and the master switch for all technological issues, emphasizing that it must be advanced with greater efforts and more concrete measures. Upholding long-termism in basic research means placing it at the foundation of the innovation chain and maintaining continuous investment with strategic patience characterized by a long-term horizon and high tolerance for failure. Drawing on the author’s industrial practice, this study systematically reviews the characteristics and roles of basic research throughout the development of China’s new energy vehicle industry. In light of …

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Viewpoints On Elevating Capability And Appreciation Of Basic Research, Guojie Li, Wei Zhao Jun 2026

Viewpoints On Elevating Capability And Appreciation Of Basic Research, Guojie Li, Wei Zhao

Bulletin of Chinese Academy of Sciences (Chinese Version)

The overall capability and appreciation of a country’s basic research are not solely determined by the efforts of individual researchers, but also hinge on the country’s scientific and technological institutional mechanisms and policies. This article presents several viewpoints and suggestions from the perspectives of comprehensively and deeply understanding the connotation of basic research, increasing the proportion of investment in basic research, enhancing the stable support for basic research, and the paradigm shift of AI-driven basic research. These suggestions include: by 2030, adjusting the ratio of pure basic research to oriented basic research from 3.5∶6.5 to 4.5∶5.5, maintaining a balance between …

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2026issue6content Jun 2026

2026issue6content

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

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Cover3 Jun 2026

Cover3

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.

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Overview, David L. Groves Jun 2026

Overview, David L. Groves

Visions in Leisure and Business

No abstract provided.

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Introduction, David L. Groves Jun 2026

Introduction, David L. Groves

Visions in Leisure and Business

No abstract provided.

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Evolution And Assessment Of Employee/Workplace Services, David L. Groves Jun 2026

Evolution And Assessment Of Employee/Workplace Services, David L. Groves

Visions in Leisure and Business

No abstract provided.

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Ps, David L. Groves Jun 2026

Ps, David L. Groves

Visions in Leisure and Business

No abstract provided.

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Prmt5 As A Key Driver Of Stemness And Metastatic Potential In Triple-Negative Breast Cancer, Jae Jin Jeong, Mauli Maniar, Shahrzad Ghane, Sakshi Deshpande, Claire Ellis, Ashakumary Lakshmikuttyamma Jun 2026

Prmt5 As A Key Driver Of Stemness And Metastatic Potential In Triple-Negative Breast Cancer, Jae Jin Jeong, Mauli Maniar, Shahrzad Ghane, Sakshi Deshpande, Claire Ellis, Ashakumary Lakshmikuttyamma

College of Pharmacy Faculty Papers

Protein arginine methyltransferase 5 (PRMT5) mediates arginine methylation of a wide range of proteins and plays context-dependent oncogenic or tumor-suppressive roles. In cancer, PRMT5 represses several tumor suppressor genes, including E-cadherin, TP53BP1, ST7, PTEN, and RB (retinoblastoma). Elevated PRMT5 expression has been reported across multiple cancer types, notably triple-negative breast cancer (TNBC). In TNBC, high PRMT5 levels are associated with enhanced cancer stem cell self-renewal, increased tumor growth and metastasis, and reduced patient survival. Mechanistically, PRMT5 promotes breast cancer stem cell maintenance and proliferation through stabilization of the transcription factors KLF4 and KLF5. Disruption of the PRMT5-KLF4 axis results in …

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