Digital Commons Network^™

Systematic Observation, Brizel Trinidad, Lisa K. Lashley, Charles J. Golden

Essays in Developmental Psychology

Systematic observation is the process of explicitly defining desired target behaviors and observing them using a systematic set of guidelines. Systematic observation assists in reducing or eliminating bias in experimental designs. The reduction allows for increased reliability and validity therefore, an integral part in experimental designs. This process is widely used in school, home, and clinical settings. The process allows preset rules and guidelines to be to be followed prior to beginning the experiment. The rules and guidelines maintain the design within reasonable boundaries. All the preset rules are inferred prior to starting the experiment.

Temperament, Aya Shigeto

Essays in Developmental Psychology

John Locke, an English philosopher, stated that all babies come to the world with a blank slate or tabula rasa, ready to absorb everything that their outside world has to offer. Behaviorists like John B. Watson similarly advocated the power of nurture (i.e., learning) and disregarded the contribution of nature (i.e., biology, genetics) to human development. Researchers today agree that babies are born with unique characteristics called temperament and that these individual differences in behavior, affect, and attention are believed to have genetic and biological bases. However, researchers also agree that temperament is not immune to environmental influences. In other …

Distinct Adipose Progenitor Cells Emerging With Age Drive Active Adipogenesis, Guan Wang, Gaoyan Li, Anying Song, Yutian Zhao, Jiayu Yu, Yifan Wang, Wenting Dai, Martha Salas, Hanjun Qin, Leonard Medrano, Joan Dow, Aimin Li, Brian Armstrong, Patrick T Fueger, Hua Yu, Yi Zhu, Mengle Shao, Xiwei Wu, Lei Jiang, Judith Campisi, Xia Yang, Qiong A Wang

Children’s Nutrition Research Center Staff Publications

Starting at middle age, adults often suffer from visceral adiposity and associated adverse metabolic disorders. Lineage tracing in mice revealed that adipose progenitor cells (APCs) in visceral fat undergo extensive adipogenesis during middle age. Thus, despite the low turnover rate of adipocytes in young adults, adipogenesis is unlocked during middle age. Transplantations quantitatively showed that APCs in middle-aged mice exhibited high adipogenic capacity cell-autonomously. Single-cell RNA sequencing identified a distinct APC population, the committed preadipocyte, age-enriched (CP-A), emerging at this age. CP-As demonstrated elevated proliferation and adipogenesis activity. Pharmacological and genetic manipulations indicated that leukemia inhibitory factor receptor signaling was …

Functional Screening Identifies Kinesin Spindle Protein Inhibitor Filanesib As A Potential Treatment Option For Hepatoblastoma, Ruth Nousiainen, Katja Eloranta, Jani Saarela, Antti Hassinen, Tamara J Luck, Stefano Cairo, Emilie Indersie, Swapnil Potdar, Michaela J Feodoroff, Jouko Lohi, Lassi Paavolainen, David B Wilson, Vilja Pietiäinen, Markku Heikinheimo, Marjut Pihlajoki

2020-Current year OA Pubs

Hepatoblastoma is a rare pediatric liver malignancy usually treated with surgery and chemotherapy. To explore new treatment options for hepatoblastoma, drug screening was performed using six cell models established from aggressive hepatoblastoma tumors and healthy pediatric primary hepatocytes. Of the 527 screened compounds, 98 demonstrated cancer-selective activity in at least one hepatoblastoma model. The kinesin spindle protein (KSP) inhibitor filanesib was effective in all models and was further evaluated. Filanesib induced G2/M arrest and apoptosis in hepatoblastoma cells at concentrations tolerable to primary hepatocytes. Prominent nuclear fragmentation was observed in filanesib-treated hepatoblastoma cells. Genes participating in cell cycle regulation were …

Deciphering Distinct Genetic Risk Factors For Ftld-Tdp Pathological Subtypes Via Whole-Genome Sequencing, Cyril Pottier, Carlos Cruchaga, Et Al.

2020-Current year OA Pubs

Frontotemporal lobar degeneration with neuronal inclusions of the TAR DNA-binding protein 43 (FTLD-TDP) is a fatal neurodegenerative disorder with only a limited number of risk loci identified. We report our comprehensive genome-wide association study as part of the International FTLD-TDP Whole-Genome Sequencing Consortium, including 985 patients and 3,153 controls compiled from 26 institutions/brain banks in North America, Europe and Australia, and meta-analysis with the Dementia-seq cohort. We confirm UNC13A as the strongest overall FTLD-TDP risk factor and identify TNIP1 as a novel FTLD-TDP risk factor. In subgroup analyzes, we further identify genome-wide significant loci specific to each of the three …

Development And Evaluation Of A Non-Invasive Brain-Spine Interface Using Transcutaneous Spinal Cord Stimulation, Carolyn Atkinson, Lorenzo Lombardi, Meredith Lang, Rodolfo Keesey, Rachel Hawthorn, Zachary Seitz, Eric C Leuthardt, Peter Brunner, Ismael Seáñez

2020-Current year OA Pubs

Motor rehabilitation is a therapeutic process to facilitate functional recovery in people with spinal cord injury (SCI). However, its efficacy is limited to areas with remaining sensorimotor function. Spinal cord stimulation (SCS) creates a temporary prosthetic effect that may allow further rehabilitation-induced recovery in individuals without remaining sensorimotor function, thereby extending the therapeutic reach of motor rehabilitation to individuals with more severe injuries. In this work, we report our first steps in developing a non-invasive brain-spine interface (BSI) based on electroencephalography (EEG) and transcutaneous spinal cord stimulation (tSCS). The objective of this study was to identify EEG-based neural correlates of …

Comparative Efficacy And Acceptability Of Interventions For Universal, Selective And Indicated Prevention Of Eating Disorders: Study Protocol For A Systematic Review And Network Meta-Analysis, Sandra Schlegl, Felicitas Hirler, Andreas Gerich, Mikkel Højlund, Eric Stice, Tracey Wade, Denise Wilfley, James Downs, Ulrich Voderholzer, Jasmine Perry, Verena Haas, Marco Solmi, Christoph Correll

2020-Current year OA Pubs

BACKGROUND: Eating disorders (EDs) are severe psychiatric conditions, with prevalence rates ranging from 5.5 to 17.9% in women and 0.6 to 2.4% in men. EDs carry a high risk of chronicity and mortality, highlighting the need for effective prevention strategies. Primary prevention can target the entire population (universal), high-risk groups (selective), or individuals with early signs (indicated). Despite substantial research, prior reviews often show limitations, such as single-author data extraction, lack of quality assessment, reliance on endpoint data, exclusion of obesity prevention programs, or outdated findings. No review has yet evaluated the comparative effectiveness of multiple interventions across risk groups. …

Octavio Macias Ramirez, Petitioner V. The Honorable Clemens Landau, Salt Lake City Justice Court, Respondent.: Response To Petition For Extraordinary Writ

Utah Appeals Court Briefs

from Order of Dismissal Without Prejudice in SALT LAKE CITY v. OCTAVIO

Widowhood, Kirsten Horne, Lisa K. Lashley, Charles J. Golden

Essays in Developmental Psychology

Widowhood is defined as the state or period of being a widow or widower.  A widow is a female whose spouse has died, while a widower is a male whose spouse has died.  Although both men and women are likely to experience widowhood, research indicates that women are more likely to be widowed than men. Research suggests there are two main reasons why women are more likely to be widowed. First, women in average live longer than men. The second reason consists of the idea that women tend to marry older men. (Now that the USA and many other countries …

Writing Skills: The Essentials, Gina Braun

Essays in Developmental Psychology

Writing Skills are an essential component of communicating and develop over time. It does not matter the intention of writing, it is a skill used daily, and we must prepare our students to have the adequate skills they will need to function as writers. Writing skills taught in school are focused on academic writing, which should transfer and generalize across settings. Writing skills take on different forms with a variety of levels of importance. The necessary writing skills needed include; the writing process, which is supported by, mechanics, writing for a variety of purposes, and finally, building technological skills.

Work-Family Conflict, Alexandra M. Daro, Samantha K. Ammons

Essays in Developmental Psychology

Individuals will take on many different roles throughout their lives. Three of the largest roles an individual can take on – employee, spouse, parent – often come into conflict with each other. Work-family conflict occurs when demands at work and demands in the family are incompatible.  The term “family” can mean different things to different people. Although we often think of family members as individuals tied to us through blood or marriage, families can also be comprised of other loved ones, close friends, and even pets.

Word Learning Styles, Diana Hincapie, Lisa K. Lashley, Charles J. Golden

Essays in Developmental Psychology

Language acquisition is the way that humans learn and attain their spoken language. Infants are biologically equipped to attain four aspects of language. These include phonology, semantics, grammar, and pragmatics. The earliest acquired language begins with phonology, attained as early as three months and make rapid progressions to conversational language by four years of age.

Word Learning Rules In Children, Caitlin F. Herman, Lisa K. Lashley, Charles J. Golden

Essays in Developmental Psychology

The ability to learn new words requires the use of numerous cognitive functions. It is expected that from the time a child begins speaking around 12 months of age to about six years old, children learn approximately 14,000 words (Templin, 1957 as cited in Brady & Goodman, 2014).  From an early age, children are exposed to the language used around them and slowly develop their own use of language through recognition of objects, combination of phonemes, and memorization of visual and auditory stimuli. In order to successfully master language and learn new words, a child must integrate these processes to …

The Dynamic Immune Behavior Of Primary And Metastatic Ovarian Carcinoma, Elaine Stur, Fuduan Peng, Pang-Ning Teng, Emine Bayraktar, Min Hu, David J Brown, Kathleen N Moore, Nicholas W Bateman, Kathleen M Darcy, George L Maxwell, Thomas P Conrads, Nidhi Sahni, Ignacio Vázquez-García, Sohrab P Shah, Joseph Celestino, Nicole D Fleming, Nicholas E Navin, Linghua Wang, Anil K Sood

Faculty, Staff and Student Publications

Patients with high-grade serous ovarian carcinoma (HGSC) are usually diagnosed with advanced-stage disease, and the tumors often have immunosuppressive characteristics. Together, these factors are important for disease progression, drug resistance, and mortality. In this study, we used a combination of single-cell sequencing and spatial transcriptomics to identify the molecular mechanisms that lead to immunosuppression in HGSC. Primary tumors consistently showed a more active immune microenvironment than did omental tumors. In addition, we found that untreated primary tumors were mostly populated by dysfunctional CD4 and CD8 T cells in later stages of differentiation; this, in turn, was correlated with expression changes …

A Pioneering Artificial Intelligence Tool To Predict Treatment Outcomes In Ovarian Cancer Via Diagnostic Laparoscopy, Xiaotian Ma, Yu-Chun Hsu, Amma Asare, Kai Zhang, Deanna Glassman, Katherine Foster, Shannon Westin, Amir Jazaeri, Nicole D Fleming, Pratip K Bhattacharya, Xiaoqian Jiang, Anil K Sood, Shayan Shams

Faculty, Staff and Student Publications

Ovarian cancer is associated with high rates of patient mortality and morbidity. Laparoscopic assessment of tumor localization can be used for treatment planning in newly diagnosed high-grade serous ovarian carcinoma (HGSOC). While spread to multiple intra-abdominal areas is correlated with worse outcomes, whether other morphological tumor differences are also associated with patient outcomes is unknown. Given the large volume of visual information in laparoscopic videos, we investigated whether deep-learning models can capture implicit features and predict treatment outcomes. We developed a novel deep-learning framework using pre-treatment laparoscopic images to assess clinical outcomes following upfront standard treatment, defined as short progression-free …

Acute Brcaness Induction And Ar Pathway Blockage Through Cdk12/7/9 Degradation Enhances Parp Inhibitor Sensitivity In Prostate Cancer, Fu Gui, Baishan Jiang, Jie Jiang, Zhixiang He, Takuya Tsujino, Seiji Arai, Jens Köllermann, Gary Andrew Bradshaw, Robyn Eisert, Marian Kalocsay, Anne Fassl, Steven P Balk, Adam S Kibel, Li Jia

Faculty, Staff and Student Publications

Current treatments for advanced prostate cancer (PCa) primarily target the androgen receptor (AR) pathway. However, the emergence of castration-resistant prostate cancer (CRPC) and resistance to AR pathway inhibitors (APPIs) remains ongoing challenges. Here, we present BSJ-5-63, a proteolysis-targeting chimera (PROTAC) targeting cyclin-dependent kinases (CDKs) CDK12, CDK7, and CDK9, offering a multipronged approach to CRPC therapy. BSJ-5-63 degrades CDK12, diminishing BRCA1 and BRCA2 expression and inducing a sustained "BRCAness" state. This sensitizes cancer cells to PARP inhibitors (PARPis) regardless of their homologous recombination repair (HRR) status. Furthermore, CDK7 and CDK9 degradation attenuates AR signaling, enhancing its therapeutic efficacy. Preclinical studies, including …

Tfcp2 Fusion-Positive Rhabdomyosarcomas: A Report Of 10 Cases And A Review Of The Literature, Alexander J Lazar, Shreyaskumar Patel, John Andrew Livingston

Faculty, Staff and Student Publications

Background/Objectives: The fusion of the TFCP2 gene with either EWSR1 or FUS typically results in a spindle cell and/or epithelioid variant of rhabdomyosarcoma. This is an ultra-rare type of sarcoma, with most of our knowledge about these coming from case reports and small case series. Herein, we describe the clinical characteristics and treatment course of 10 patients with TFCP2 fusion sarcomas.

Methods: We identified 10 patients in our hospital system with TFCP2 fusion sarcomas and 43 previously reported cases in the literature. We assessed primary tumor characteristics, treatment regimens, and survival rates among all cases.

Results: We find that …

From Property Rights To Human Rights: Combating Forced Partition In Louisiana With The Uniform Partition Of Heirs Property Act, Ashton Austin

Louisiana Law Review

No abstract provided.

Adipose-Derived Leptin And Complement Factor D Mediate Osteoarthritis Severity And Pain, Kelsey H Collins, Kristin L Lenz, Hope D Welhaven, Erica Ely, Luke E Springer, Sophie Paradi, Ruhang Tang, Lauryn Braxton, Antonina Akk, Huimin Yan, Bo Zhang, Xiaobo Wu, John P Atkinson, Arin K Oestreich, Ron K June, Christine T N Pham, Farshid Guilak

2020-Current year OA Pubs

Obesity is a risk factor for osteoarthritis (OA), and leptin is among the adipokines implicated in obesity-induced OA. However, the specific role of leptin in OA severity and pain is not known. Using lipodystrophic (LD) mice, we show that fat-secreted factors are required for knee OA development, implicating a fat-cartilage cross-talk. Fat pad implantation or systemic leptin restoration in LD mice reintroduced structural OA and pain, whereas implantation of leptin-deficient fat pad did not change OA susceptibility. Isochronic parabiosis and spatial transcriptomics confirmed that a fat-joint cross-talk likely occurred via soluble mediators. Global unsupervised multiomics of conditioned media from fat …

Economic Development In Ten Massachusetts Communities: A Study Of Public Policy Implementation Methods And Outcomes, Derek Michael Bennett

Walden Dissertations and Doctoral Studies

Economic renewal and development are an essential elements of urban economic development within numerous cities in the United States. Little has been reported concerning methods used to implement policy to create the conditions desirable for economic growth and development. The purpose of this study was to investigate the corelative relationship between implementation methods used and the outcomes of economic growth and development policy, applying Pierson's (1993) Policy Feedback Theory as the theoretical framework. Using a mixed methods-based study of quantitative and quantitative methods, to examine the correlation between policy implementation practices and resulting barriers in local economic growth and development, …

Relation Of Persistent Organic Pollutant Exposure With Autism, Gender, Age, And Body Mass Index, Tekle Mitiku

Walden Dissertations and Doctoral Studies

Approximately one third (37%) of children in the United States are impaired with autism spectrum disorder (ASD) resulting in intellectual disability, and about 1 in 6 children in the United States has one or more developmental disabilities. The economic burden of ASD is estimated to be over $40 billion lost per year. The purpose of this study was to determine the relationship of polybrominated diphenyl ether derivatives (PBDEs) with ASD, age, gender, and body mass index (BMI). The conceptual framework of the study was based on the physiologically based pharmacokinetic theory that the body burden of PBDEs’ free radicals may …

Hegemonic Masculinity: Exploring How Asian And Pacific Islander Emerging Adult Males Describe Masculinity, Eman'on Wanderer

Walden Dissertations and Doctoral Studies

The phenomenon of hegemonic masculinity presents a significant mental health concern among diverse emerging adult males. This generic qualitative study was an exploration of the perspectives of Asian and Pacific Islander emerging adult males regarding their descriptions of masculinity. Gender schema theory (GST) is the foundational framework of this study. Rooted in social cognitive theory, GST exemplifies how environmental factors shape the initial development of gender identity and the enduring effects this gendering has on cognitive processes throughout an individual's life. The primary research question in this study was: How do Asian and Pacific Islander emerging adult males describe masculinity? …

Clinical Practice Guideline For Patient Education On Indwelling Catheters In The Home, Lyndsy Bolstad

Walden Dissertations and Doctoral Studies

Home healthcare agencies transition patients from the hospital to the home where caregivers may assist in providing care for indwelling Foley catheters. About half of urinary tract infections are in the presence of an indwelling catheter. The agency for which this Doctor of Nursing Practice project was developed does not have an evidence-based clinical practice patient education guideline (CPPEG) for the care of the indwelling catheter to prevent infection. The practice-focused questions were: (a) What evidence-based literature supports the development of a CPPEG for patient education on the care of the Foley catheter in the home and (b) Will the …

Alternative Solutions For Leadership To Attract Qualified Behavioral Health Professionals In Rural Areas, Jerilyn Ann Durst

Walden Dissertations and Doctoral Studies

The challenge of attracting qualified behavioral health professionals to positions in rural areas has been widely recognized. Underserved population segments, issues unique to clinicians practicing in rural areas, and a lack of effective recruitment incentives impact not only an organization but also the community it serves. The subject of this qualitative case study was a private behavioral health office located in a rural community. Semistructured interviews were held with five behavioral health leaders of this organization in addition to a review of organizational records. The Baldridge Performance Excellence Program was the conceptual framework that grounded this study. Qualitative analysis, including …

Organization Change Process Initiative Recurrent Emergency Room Visits By Mental Health And Substance Use Patients, Julie Marie Tucker

Walden Dissertations and Doctoral Studies

The rising rates of patients diagnosed with mental health and substance use disorders (MHSUD) signify a critical national crisis, worsened by the COVID-19 pandemic, as reported by the United States Department of Health and Human Services. This increase has reduced access to essential resources and treatment options, resulting in overcrowded emergency rooms (ER) and extended wait times. Addressing these issues is vital for nursing practice, as they significantly influence patient care and health outcomes, especially for vulnerable populations. This doctoral project explores whether an organizational change designed to raise awareness of updated community resources impacts MHSUD patient visits to the …

How Is The Psychological Well-Being Of The Prospective Counselor: The Perma-Profiler, Yessika Nurmasari, Moh. Khoerul Anwar, Muhsin Muhsin, Do Mai Lam

Jurnal Kajian Bimbingan dan Konseling

Well-being is one of the factors that prospective counselors continue to develop themselves and their profession. The research aims to provide an overview of the psychological well-being of prospective counselors. The study used the PERMA-Profiler measurement, distributed to Islamic Counseling Guidance students at UIN Sunan Gunung Djati Bandung. The data were analyzed by quantitative descriptive with simple random sampling. The attachment indicator (E) is the largest at 7.48, followed by the positive emotion indicator (P) at 7.44, the meaningfulness indicator (M) with a score of 7.39, the relationship indicator ® with a score of 7.21, the achievement indicator (A) with …

Utah State University, Petitioner V. Utah Labor Commission And Leila Setayeshgar, Respondents : Brief Of Appellee, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

On Petition for Review From Utah Labor Commission, Adjudication Division, Case No. 8-00-0179 Leila Setayeshgar, Petitioner, vs. Utah State University, Respondent ALJ Brian Stewart, presiding

Attorneys for Utah State University, Appellant/Petitioner, Joshua D. Davidson

Attorneys for Leila Setayeshgar, Appellee/Respondent, Wayne K. Caldwell, Aaron K. Bergman, Aubri O. Thomas

Bayesian Methodology To Model Field Failures Using Precise Operating Time, Ravi Teja Chikkam, Sean C Pegado, Colin Joseph Lacy

Defensive Publications Series

Field failures of products are frequently modeled using a constant failure rate assumption along with biased device usage times. This methodology provides convenience but may be inaccurate due to the failure rate assumptions and unavailability of precise device usage data. Techniques described herein provide for computing the precise device usage time along with assuming varying failure rates to better estimate field failures.

Use It Or Lose It: Examining The Language Use, Acquisition, And Transmission Of Irish In Ireland And Minority Languages In The United States Through Study Abroad, Taylor Mcpadden

Academic Festival

This paper explores the interplay of language use, acquisition, and transmission, with a primary focus on the Irish language in Ireland and comparisons to minority languages in the United States. It delves into the historical, cultural, and societal factors including colonization, educational policies, and societal attitudes that have influenced the status of the Irish language. Through the lens of pragmatics, this analysis highlights how language serves as both a tool for communication and a carrier of cultural identity, emphasizing the importance of meaningful language use in sustaining minority languages. Comparisons to the United States illuminate parallels in challenges such as …

What The Focal?, Christopher Iles

Academic Festival

This paper focuses on exploring the rich oral tradition of Irish storytelling through a linguistic and cultural lens, highlighting its distinct narrative structures. Focusing on alliterative runs—mnemonic, rhythmic linguistic patterns unique to the Irish language—the study compares traditional Irish storytelling with the predominantly written American narrative tradition. The Irish storytelling's oral heritage fosters unique linguistic features that can be misunderstood or misdiagnosed in clinical contexts when assessed through a standard American English framework. The paper emphasizes the need for cultural competence in speech-language pathology, especially when evaluating narrative skills across different linguistic traditions. Translation and cultural misunderstanding can obscure the …