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Prooxidant Effect Of Uric Acid On Human Leukocytic Dna: An In Vitro And Ex Vivo Study, Yim Tong Savio Szeto, Vincy Sze Wing Li, Yuen Lam Pon

Turkish Journal of Biology

Background/aim: Uric acid is a major contributor to the total antioxidant capacity of human plasma. However, this endogenous substance’s antioxidant and prooxidant properties have not yet been reported.

Conclusion: In this study, the comet assay was employed in vitro to determine the effect of uric acid on DNA damage in human lymphocytes and leukocytic DNA damage in hyperuricemia patients with and without renal failure.

Results: DNA damage in lymphocytes occurred at uric acid concentrations of ≥600 μM. Adding catalase to the uric acid solution diminished the damaging effect, indicating that hydrogen peroxide mediated the prooxidant activity. Moreover, …

Intrinsic Apoptotic Effect Of Anatolian Honeybee (Apis Mellifera Anatoliaca) Venom Promoted With Mesoporous Silica Nanocarriers, Batuhan Orman, Ayli̇n Koç, Di̇dem Şen Karaman, Ayşe Nalbantsoy

Turkish Journal of Biology

Background/aim: The use of bee products or treatment with bees, as a complement to conventional medicine is attracting considerable attention in cancer research. Although discoveries related to the potential anticancer effects of bee venom are increasing, the unstable nature of venom biomolecules remains a limiting factor for their usage. In this study, we employed mesoporous silica nanocarriers (MSNs) to provide precise dosing and prevent carriers from biomolecule degradation thanks to the outstanding loading capacity provided by the pores, excellent chemical and biological robustness, and ability to improve bioavailability.

Materials and methods: MSNs were synthesized and physicochemical characterizations were …

Resveratrol Modulates Triosephosphate Isomerase And Mineralization In Osteosarcoma Cells: Potential Target For Novel Therapeutic Strategies, Gonca Tuna, Si̇bel Çinar Asa, Eli̇f Ertürk, Yaren Yildiz, Ferda Ari

Turkish Journal of Biology

Background/aim: Osteosarcoma, a primary malignant bone tumor, is challenging to treat due to its aggressive nature and limited therapies. Resveratrol (RES), a natural polyphenol, has potential anticancer properties. Hence, we investigated RES’s impact on osteosarcoma cells, focusing on triosephosphate isomerase (TPI) and related mechanisms.

Materials and methods: RES was applied to osteosarcoma (SaOS-2) and healthy fetal osteoblast (hFOB 1.19) cells for 48 h, and cell viability was measured by SRB assay. The mode of cell death was examined using Hoechst 33342/annexin V/propidium iodide. TPI and methylglyoxal (MG) enzyme levels were determined by ELISA. The effect of RES on …

N-Cadherin Mimetic Hydrogels Drive Superior Regenerative And Paracrine Responses In 3d Cultures Of Adipose-Derived Mesenchymal Stem Cells, Demet Kaçaroğlu, Alper Murat Ulaşli, Aybüke Di̇denur Sak, Seher Yaylaci

Turkish Journal of Biology

Background: Cadherin-based biomaterials play a pivotal role in influencing the fate of mesenchymal stem cells (MSC). Enhancing the adhesion of adipose tissue-derived MSCs has been shown to augment their paracrine effects while N-cadherin biomaterials have been suggested to regulate the paracrine effects of MSCs via specific growth factors although the precise mechanisms underlying this regulation remain insufficiently understood. This study aims to compare the effects of a 3D N-cadherin mimetic environment on cell viability, apoptosis, extracellular matrix regulation, and growth factor expression with those observed in traditional 2D and 3D spheroid cultures. Additionally, the study seeks to evaluate the …

Knockdown Of Plexin C1 Induces Epithelial-To-Mesenchymal Transition And Confers Resistance To Multikinase Inhibitors In Hepatocellular Carcinoma Cells, Gamze Güngör Topcu, Arzu Aysan, Şevval Di̇k, Mai̇de Şeker, Meli̇ke Bi̇nnur Bahçekapili, Sude Topkaraoğlu, Di̇lek Yavuzer, Tamer Yağci

Turkish Journal of Biology

Background/aim: HCC is a common and lethal malignancy and multi-kinase inhibitors (MKIs) are among the therapeutic options for unresectable cases. However, response rates to MKIs remained variable, necessitating the identification of predictive biomarkers. Plexin C1 (PLXNC1), a receptor involved in cell signaling, has emerged as a potential candidate to regulate tumor responses. This study aims to evaluate the impact of PLXNC1 expression on the sensitivity of HCC cells to MKI therapy.

Materials and methods: shRNA-mediated PLXNC1 knock-down and control clones of HCC cell lines PLC/PRF/5 and Hep3B were generated, and downregulation of PLXNC1 was confirmed using Western blotting. …

Sexuality: Issues In Adulthood, Taylor D. Michl, Amanda Kracen

Essays in Developmental Psychology

Human sexuality in Western cultures is generally comprised of emotional intimacy, sexual identity, and sexual behavior. Sex is understood and experienced differently by people as aspects of identity (e.g., culture, race, class, gender, ability, size, religion, sexual identity) affect sexuality. Although engaging in sex is not necessary for a fulfilling life, the majority of adults in the U.S. participate in sexual activity, and regular sexual activity correlates with improved mental health (Brody, 2010).

Dementia, Anna C. Mccarrey

Essays in Developmental Psychology

Dementia is a progressive condition that causes the sufferer to have problems with memory, thinking and behaviors beyond what is expected from the normal aging process. It is the most common neurological disorder in old age, although some types of dementia can occur earlier in the lifespan. Dementia is characterized by severe memory impairment, as well as problems with other psychological functions such as attention, reasoning and problem-solving. Late stage dementia can lead to total erosion of the person and self with the sufferer having trouble speaking, eating, walking and being able to dress themselves. The word dementia comes from …

States-In-Waiting: A Counternarrative Of Global Decolonization, Sannoy Das

Vanderbilt Law School Faculty Publications

How should we, international lawyers, especially with an interest in history, apprehend the experience of, and the horizon of expectation that opened up with, the dissolution of European empires in the decades following the end of World War II? We know that during these decades a Eurocentric international order marked by alien rule and the denial of statehood to large swathes of the world's population was nominally transformed into one marked by sovereign equality. Triumphalist accounts of progress would yoke this transformation to the realization of other good things such as human rights, and economic development.But more commonly today, we …

Caregivers’ Satisfaction With And Perceived Cultural Sensitivity Of A Modification Of A Child Injury Prevention Program For Spanish-Speaking Families, Karen Padilla

Honors Theses

Unintentional injuries are a leading cause of death among children in the United States. Caregivers play a critical role in reducing children’s risk of injury by adopting appropriate supervision behaviors and engaging in safety-proofing practices. The Supervising for Home Safety (SHS) program is a video-based intervention developed to increase caregiver supervision for children ages 2–5 by targeting beliefs about injury vulnerability, injury preventability, and self-efficacy for implementing safety precautions. While SHS has demonstrated effectiveness in English-speaking populations, no research has examined its adaptation and impact among Spanish-speaking caregivers. This study aimed to examine caregivers perceived cultural sensitivity and satisfaction with …

The Bacon, April 25, 2025, Beacon Staff

The Beacon, 2024-2025

Mugs filled to brim with mystery; Conhof can't read this headline; Crisis of a lifetime: man or muppet?; crime runs rampant at Northwestern; Conhof inducted into Roller Derby; Still winless after 46 runner-up finishes; "Poet of Polka" drops third album; Local legend takes control of tiny island;

Mirror Test Of Infant Self-Awareness, Jenna Bekkala, Naomi J. Aldrich

Essays in Developmental Psychology

Our understanding of self, or belief in one’s being as distinct from others, has been a subject of inquiry throughout human history. Discussions of self-concept would not appear in the empirical literature, however, until the mid-19th century. After likening an orangutan’s response to teasing as that of a “naughty child”, Charles Darwin began to question orangutans’ selfconcept by observing reactions to their own mirror images. Darwin’s use of the mirror to gauge self-awareness, a method eventually applied to his own infant son (Darwin, 1877), would remain the most frequently used assessment of self-concept for the next century.

Attachment Theory: John Dollard And Neal Miller, Carla Cabrera, Lisa K. Lashley, Charles J. Golden

Essays in Developmental Psychology

No abstract provided.

Bio-Physiological Development During Adulthood, Maria Boix Braga, Charles J. Golden, Lisa K. Lashley

Essays in Developmental Psychology

Defining adulthood, and what the criteria truly is to be able to consider oneself an adult, varies from culture to culture. Biologically, adulthood can also be defined as the period in which full physical and intellectual maturity has been attained. It is a period that is defined slightly differently depending on the source, but it is agreed that it tends to be considered the life period between ages 18 and 60. However, the definition of adulthood can have varying legal and sociocultural factors as well. For example, the legal definition of an adult is a person who has reached the …

Experimental Studies, Alexander Beaujean, Allison D. Gutierrez

Essays in Developmental Psychology

The concept of an experiment has undergone many changes in psychology's relatively short existence, and its essential features are still debated. Psychologists agree that it involves (a) systematically observing and recording phenomena; (b) explicitly describing the conditions under which the observations occurred, and (c) analyzing the resulting data to look for meaningful relations. The major area of disagreement is whether manipulation of phenomena is required.

Correlational Studies, Alexander Beaujean, Hannah Greeley

Essays in Developmental Psychology

Correlational studies are a type of research design that involves examining the relation among two or more phenomena. The design's distinguishing features are (a) data are collected more or less simultaneously, or at least treated as if they were collected at a single point in time; and (b) there is no manipulation of phenomena (e.g., assigning participants into groups).

Longitudinal Studies, Alexander Beaujean

Essays in Developmental Psychology

Longitudinal studies provide information about phenomena constancy and change. Their core feature is that the phenomena under investigation are observed repeatedly in the same participants (e.g., persons, animals, organizations), which requires collecting data at multiple time points (called waves). The participants, phenomena observed, duration of study, and number of waves can greatly differ between studies. For example, longitudinal studies with animals often gather data across many waves, but the entire study may only last a few days or weeks. By contrast, longitudinal studies with humans typically gather data at just a few waves but may last years or decades.

Infant Memory, Jenna Beffel, Naomi J. Aldrich

Essays in Developmental Psychology

Until the second half of the 20th century, the ability to recall information was thought to emerge between 2- and 10-years-of-age. Resulting from repression of our earliest sexual urges, immature neural mechanisms, or an impoverished sense of self and linguistic skills, infantile amnesia represents the predominant view of infancy at the time; a period in which the child possessed remarkably limited mental abilities, thus experiencing the world as nothing more than “one great blooming, buzzing confusion” (James, 1890). The research contributions of Dr. Carolyn Rovee-Collier over the next seventy years succeeded in altering this perspective.

Divorce, Effect On Child Development, Vijay Bajnath, Lisa K. Lashley, Charles J. Golden

Essays in Developmental Psychology

Childhood experiences of divorce affect multiple domains of development. Cognitive, emotional and physical areas of a child’s development may be impacted by the separation.  Models of development which take into account both biological and environmental influences suggest that problems of divorce impact the parental practices towards the children which lead to difficulties in emotional regulation and insecurity. These arenas impact health in both explicit health risk behaviors as well as biological responses within the body. The combination of these seen and unseen processes contribute to an overall impact on health.

Infant Imitation And Social Interaction, Caroline Bartes, Naomi J. Aldrich

Essays in Developmental Psychology

Today imitation (i.e., copying another’s behaviors) is recognized as the fundamental mechanism by which cultural knowledge is socially transmitted across generations (Gergely & Csibra, 2006). Indeed, inquiries into children’s imitation have been at the forefront of developmental science nearly since its inception. Piaget suggested that at its core, imitation acted as the child’s representation of self-in-action before the representation of self-in-thought (Piaget & Inhelder, 1966/1969). While Piaget discussed the presence of reflexive imitation within the first months of life (e.g., a baby crying upon hearing another baby’s cry), he reasoned that children could not imitate others’ gestures until the end …

Sequential Studies, A. Alexander Beaujean

Essays in Developmental Psychology

Sequential studies combine aspects of longitudinal and cross-sectional studies in order to overcome some of inherent problems in both designs. Longitudinal studies can provide rich information about phenomena change, but have two major disadvantages: (a) they can require substantial resources, and (b) they can confound effects of age, cohort (i.e., influences due to shared historical experiences), and time-of-data-collection effects (i.e., events that co-occur with the data collection occasions). Cross-sectional studies require fewer resources, but only provide limited information about developmental change.

Cross-Sectional Studies, Alexander Beaujean, Allison D. Gutierrez

Essays in Developmental Psychology

Cross-sectional studies are a type of research design used to understand time-related constancy and change in phenomena using data collected more or less simultaneously from different groups (called cohorts) of participants (e.g., people, animals, organizations). The cohorts vary on the basis of age or some other temporal phenomena (e.g., developmental stage, grade in school), so the combined sample is thought to represent the focal phenomena in the population at different times (i.e., a cross section). Differences among the cohorts are used to approximate developmental changes.

Prosocial Reasoning, Ryan Bennett, Lisa K. Lashley, Charles J. Golden

Essays in Developmental Psychology

Prosocial behavior is best described as a general range of actions that are intended to benefit individuals other than one’s self. Some of these prosocial actions include helping, comforting, and sharing with others (Batson & Powell, 2003). More specifically, prosocial behavior is better understood as one’s voluntary action that is solely meant to benefit others. Prosocial reasoning is the motivating influences for an individual to engage in a prosocial behavior. Some research suggests that reasoning behind prosocial behavior is a motivation toward altruism, a principle in which one individual is selfless and engages in behaviors that help others, despite personal …

April 25, 2025 Minutes, Swosu Faculty Senate

Faculty Senate Minutes

No abstract provided.

Newborn Senses, Ryan Bennett, Lisa K. Lashley, Charles J. Golden

Essays in Developmental Psychology

When babies are born, they possess all five senses-taste, hearing, sight, touch and smell; however, some senses are more developed than others. Newborns had previously been an enigma to scientists and little was known about their intelligence, motives, and capabilities. Neuroscientists are now able to map out a timeline of when senses are developed during and after gestation; this has given the scientific community and parents everywhere a better understanding of newborns and their ability to process their environment.

Newborn Reflexes, Ryan Bennett, Lisa K. Lashley, Charles J. Golden

Essays in Developmental Psychology

Reflexes are characterized as involuntary movements or actions and are a key indicator of a healthy brain and nervous system in newborn babies. There are five primitive reflexes that are common for infants who do not experience central nervous system (CNS) deficits. Furthermore, newborn reflexes are also considered to add adaptive value by increasing their chances of survival.

Divorce, Effects On Relationships, Nicholas Boston, Lisa K. Lashley, Charles J. Golden

Essays in Developmental Psychology

Divorce has been seen to have significant impacts on relationships both within and outside of families. In terms of friendships, the divorced couple is often seen to withdraw from other couples prior to the divorce in order to avoid sharing uncomfortable details. With more attention instead focused on friendships with individuals, divorced couples lose some, if not all, of their couple friends, whom may take sides either individually or as a couple. As well, fellow couples may not wish to be pulled into conflict. However, individual friendships tend to strengthen as the divorcees turn their freed-up time for attention towards …

Reasons For Divorce, Ryan Bennett, Lisa K. Lashley, Charles J. Golden

Essays in Developmental Psychology

Today, divorce is a common result for many couples regarding marital conflict and discord. The impacts of divorce have been linked to increased psychological distress, increased risk of substance abuse, depression, and poorer overall health when compared to non-divorced individuals (Amato, 2000; Hughes and Waite, 2009). Per Shelby Scott and colleagues, there are ten likely reasons for a couple to get divorced (Scott et al., 2013). By understanding these ten reasons, one may better conceptualize the overall factors that contribute to divorce.

Metabolic Theories Of Aging, Chris Burley, Lisa K. Lashley, Charles J. Golden

Essays in Developmental Psychology

Metabolic theories of aging postulate that aging is due to energy expenditure, which ultimately results in the breakdown and eventual death of cells. Historically, within the realm of metabolic theories of aging, there have been three models: The Rate-of-Living theory, The Oxidative Damage/Free Radical theory, and the Metabolic Stability theory. All three theories maintain that aging is directly related to metabolic rate, but the theories differ in how they arrive at that conclusion.

Maria Montessori, Vanessa Braun, Donna Devaughn Kreskey

Essays in Developmental Psychology

Maria Tecla Artemesia Montessori (born August 31, 1870, Chiaravalle, near Ancona, Italy – died May 6, 1952, Noordwijk aan Zee, Netherlands) was an Italian educator.  She is commonly remembered for the many schools around the globe that bear her name and implement her educational methods, the Montessori system. Maria Montessori was a scientist, educator, activist, and advocate for children.

Optimizing Hydrogel Performance Composed Of Japanese Pagoda Tree Extract Loaded-Gelatin-Sodium Alginate-Polyethylene Oxide For Biomedical Applications: Influence Incorporated Calcium-Based Metal Organic Frameworks And Zinc Oxide Nps, Reham A. Shams-Eldin, Tasneem Abed, Shaza H. Aly, Rana Haikal, Rana R. Haikal, Shahira Elmosalamy, Esraa Abdelaziz, Mohamed Helmy, Ahmed Ali, Noura Eissa, Yasser Elnakady, Mahmoud Elsabahy, Elbadawy Kamoun

Nanotechnology Research Centre

No abstract provided.