Digital Commons Network^™

Humanized Saccharomyces Cerevisiae Provides A Facile And Effective Tool To Identify Damaging Human Variants That Cause Exosomopathies, Khondakar Sayef Ahammed, Milo B Fasken, Anita H Corbett, Ambro Van Hoof

Faculty, Staff and Student Publications

The RNA exosome is an evolutionarily conserved, multiprotein complex that is the major RNase in 3' processing and degradation of a wide range of RNAs in eukaryotes. Single amino acid changes in RNA exosome subunits cause rare genetic diseases collectively called exosomopathies. However, distinguishing disease-causing variants from nonpathogenic ones remains challenging, and the mechanism by which these variants cause disease is largely unknown. Previous studies have employed a budding yeast model of RNA exosome-linked diseases that relies on mutating the orthologous yeast genes. Here, we develop a humanized yeast model of exosomopathies that allows us to unambiguously assess damaging effects …

Implementing The European Open Science Cloud (Eosc) In Ireland, William Brown, Christopher Burbidge, Diarmuid Collins, Aedin Culhane, Michelle Doran, Lindsay Dowling, Venkatesh Kannan, Beth Knazook, Ruth Patricia Moran, Joan Murphy, Flaithri Neff, Jenny O'Neill, Roberto Sabatino, Laura Whelan, Shirley Wrynn

Research Outputs: 2025-Present

This paper proposes the development of a European Open Science Cloud (EOSC) Federation national node for Ireland (EOSC Ireland). EOSC Ireland will be a digital platform that connects researchers and research infrastructures across Ireland to the European-wide EOSC Federation. It allows researchers to share and access data, tools, and applications, making national and international collaboration easier. By engaging with EOSC Ireland, researchers can find and contribute new datasets, share analysis, and provide analytical tool and code that others can use, helping to advance scientific discovery. To achieve this, EOSC Ireland must establish essential functions such as resource catalogue and registry …

Side Channel Analysis Of Modern Cryptographic Processors, Srinivas Nittala

Three Minute Thesis (3MT)

No abstract provided.

Designing An Optimal Thermal Preference Arena For Southern Cricket Frog (Acris Gryllus) Juveniles, Eleanor E. Briggs, David M. Phillips Jr.

Honors Theses

Climate change has been altering ecosystems across the world at a substantial rate, disrupting the delicate ecophysiological relationships between ecosystems and the organisms that live in them. Ectotherms, such as amphibians, rely on external temperatures to behaviorally thermoregulate, making it especially imperative to study their thermal biology. Thermal preference, which assesses the environmental temperature an organism would seek out in the absence of external stimuli, provides valuable information about an amphibian’s thermal biology and can be used to predict the effects of climate change on a species or population. A commonly used method to measure thermal preference is an arena …

2025-04-17 Minutes Of The Executive Committee Of The Academic Senate, University Of Dayton. Academic Senate. Executive Committee

ECAS Minutes

Approved minutes of a meeting of the Executive Committee of the Academic Senate of the University of Dayton.

Spartan Daily, April 17, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 164, Issue 34

Supporting New Teachers Through Mentorship And Collaboration, Nathan Bleeker

Masters Projects

High teacher turnover, especially within the first five years, negatively impacts student learning, school culture, and district budgets. Mentorship, administrative support, and professional development can help reduce attrition among beginning K–12 teachers in the United States. The project aims to identify practical, evidence-based strategies that support teacher retention during these critical early years. Through a review of existing theories and literature, the project will examine how structured and collaborative mentorship programs contribute to teacher satisfaction and commitment. School administrators can utilize project components, which include a handbook for teacher mentorship and organization document for collaborative opportunities, to help support on …

Sunset Park Lp V. Roberts

All Decisions

In this nuisance holdover proceeding, the landlord alleged two isolated incidents involving the tenant's guests "one in October 2023 involving a guest who banged on the apartment door, and one in February 2024 involving a verbal dispute in the lobby. The tenant moved to dismiss under CPLR § 3211(a)(7), arguing that the termination notice failed to state a cause of action for nuisance under Rent Stabilization Code § 2524.3(b). The court agreed, citing the settled principle that nuisance requires a pattern of recurring objectionable conduct. It found that the two incidents, months apart and involving guests rather than the tenant, …

White Living Trust V. Campbell

All Decisions

Handwritten opinion. In this holdover proceeding without stated grounds, the landlord moved to file a late affidavit of service 125 days after the initial appearance. The tenant opposed, invoking Riverside Syndicate, Inc. v. Saltzman, arguing the delay was fatal. The landlord cited Siedlecki v. Doscher, claiming lack of prejudice, but failed to substantiate the claim. The court found the landlord's delay unjustified and prejudicial in light of procedural requirements, especially given the tenant's timely and persuasive opposition. The motion was denied, and the case dismissed. Practice Note: Courts strictly enforce timely service compliance; late affidavits without detailed justification and proof …

Kras Mutation Detection By Liquid Biopsy For Pancreatic Ductal Adenocarcinoma, Mahmoud Yousef, Abdelrahman Yousef, Mark W Hurd, Ashwathy Pillai, Saikat Chowdhury, Rebecca Snyder, Mark Knafl, Ryan L Lewis, Paul M Roy, Mohammad Fanaeian, Sali Albarouki, Luca F Castelnovo, Jennifer Peterson, Brandon G Smaglo, Robert A Wolff, Shubham Pant, Jason Willis, Ryan Huey, Michael Overman, Ching-Wei Tzeng, Michael P Kim, Naruhiko Ikoma, Jess E Maxwell, Matthew H G Katz, Huamin Wang, Anirban Maitra, Eugene Koay, Ethan B Ludmir, Anthony Chen, Camila Lopez, Haoqiang Ying, John Paul Shen, Dan Zhao

Faculty, Staff and Student Publications

The clinical utility of liquid biopsy (LB) for pancreatic ductal adenocarcinoma (PDAC) remain understudied. Our single-institution cohort of 311 PDAC patients with non-tumor tissues informed LB found 81.2% positivity (N = 186) in metastatic cases and in 52.4% (N = 43) of localized disease. KRAS mutations were detected in 64.6% (N = 148) of metastatic cases and 16% (N = 13) for localized disease. Positive LB, especially KRAS mutation detection, is associated with worse overall survival (OS) in metastatic PDAC (median 14.5 vs. 31.3 months, HR = 2.7, 95%CI = 1.7-4.3, P <  0.0001). The positive concordance rates of KRAS and TP53 mutations were 63% and 68% in metastatic disease but only 7% (KRAS) and 33% (TP53) in localized disease, respectively. Among the 41 patients who underwent serial liquid biopsy testing, 25% tested positive after an initial negative result. LB detects therapeutically targetable mutations in 58.5% of PDAC patients and is associated with OS.

Andrews University Wind Symphony - Spring Concert, Andrews University

Concerts and Event Programs 2024-2025

The Andrews University Wind Symphony presents its spring concert, Scenes of Summer, under the direction of Dr. Denisse Santos.

Low String Studio Recital Spring 2025, Andrews University

Concerts and Event Programs 2024-2025

The String Studio, led by Professor Carla Trynchuk, presents its Spring 2025 Low String Recital.

Multimeric Transcription Factor Bcl11a Utilizes Two Zinc-Finger Tandem Arrays To Bind Clustered Short Sequence Motifs, John R Horton, Meigen Yu, Jujun Zhou, Melody Tran, Rithvi R Anakal, Yue Lu, Robert M Blumenthal, Xiaotian Zhang, Yun Huang, Xing Zhang, Xiaodong Cheng

Faculty, Staff and Student Publications

BCL11A, a transcription factor, is vital for hematopoiesis, including B and T cell maturation and the fetal-to-adult hemoglobin switch. Mutations in BCL11A are linked to neurodevelopmental disorders. BCL11A contains two DNA-binding zinc-finger arrays, low-affinity ZF2-3 and high-affinity ZF4-6, separated by a 300-amino-acid linker. ZF2-3 and ZF4-5 share 73% identity, including five out of six DNA base-interacting residues. These arrays bind similar short sequence motifs in clusters, with the linker enabling a broader binding span. Crystallographic structures of ZF4-6, in complex with oligonucleotides from the β-globin locus region, reveal DNA sequence recognition by residues Asn756 (ZF4), Lys784 and Arg787 (ZF5). A …

April 17, 2025, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Survival Of Patients With 2014 Figo Stage Iiic High-Grade Serous Ovarian Cancer Who Treated With Platin-Based Adjuvant Chemotherapy, Mehmet Ünsal, Meltem Yücesoy, Okan Oktar, Yeşi̇m Uçar, Gülşah Ti̇ryaki̇ Güner, Okan Ayteki̇n, A.Alp Tokalioğlu, Hande Esra Koca Yildirim, Fati̇h Kiliç, Burak Ersak, Caner Çakir, Di̇lek Yüksel, Çi̇ğdem Kiliç, Sevgi̇ Koç, Günsu Ki̇myon Cömert, Özlem Moraloğlu Teki̇n, Yaprak Engi̇n Üstün, Taner Turan

Turkish Journal of Medical Sciences

Background/aim: Epithelial ovarian cancer is the second most prevalent type of gynecological cancer. We aimed to investigate prognostic factors related to survival in patient with 2014 FIGO stage IIIC high-grade serous ovarian cancer (HGSOC).

Materials and methods: Two hundred fifty eight patients were evaluated retrospectively. The absence of a visible tumor was determined as maximum cytoreduction, and a residual tumor size of 1 cm or less was determined as optimal cytoreduction. Patients who underwent cytoreduction followed by a combination of platinum and taxane adjuvant chemotherapy were included. Exclusion criteria for the study were patients taking neoadjuvant chemotherapy and those with …

A Prospective Study For The Examination Of Peripheral Blood Smear Samples In Pediatric Population Using Artificial Intelligence, Eli̇f Habi̇be Akteki̇n, Mert Burkay Çöteli̇, Ayşe Erbay, Nalan Yazici

Turkish Journal of Medical Sciences

Background/aim: Peripheral blood smear (PBS) and bone marrow aspiration are gold standards of manual microscopy diagnostics for blood cell disorders. Nowadays, data-driven artificial intelligence (AI) techniques open new perspectives in digital hematology. This study proposes an AI learning technique for the classification of blood cells over PBS samples while increasing the sensitivity and specificity rates of the experts as a decision support system of a prediagnostic tool.

Materials and methods: The methodology of this study comprises three steps for the creation of an effective learning technique for blood cell disorders. First is the digitization of PBS samples in 100x optical-digital …

Acute Effects Of Virtual Reality-Based Relaxation And Exergaming On Primary Dysmenorrhea Symptoms, Muhammed Şeref Yildirim, Merve Çoğ, Büşra Mehder Akbaş, Si̇nem Salar, Hi̇lal Kekli̇cek

Turkish Journal of Medical Sciences

Background/aim: Primary dysmenorrhea (PD) is a menstrual disorder with significant physical and psychological impacts. Physical activity and relaxation techniques are proven methods for managing PD. Advances in virtual reality (VR) suggest that immersive relaxation and exergaming could provide new avenues for symptom relief. This study aimed to investigate the acute effects of VR-based interventions on PD symptoms and compare them with a control group receiving Jacobson’s Relaxation

Materials and methods: A randomized, controlled, single-blind trial was conducted with 43 female participants aged 18–30 years with regular menstrual cycles and PD. Participants were allocated to three groups: (I) immersive VR relaxation, …

Does Dexmedetomidine Infusion Reduce The Postoperative Analgesic Need In Lumbar Disc Surgery?, Si̇bel Çatalca, Özlem Özmete, Numan Berk, Soner Çi̇vi̇, Emre Durdağ, Caner İncekaş, Nesri̇n Bozdoğan Özyilkan

Turkish Journal of Medical Sciences

Background/aim: Patients experience moderate-to-severe pain, especially in the first days after lumbar disc surgery. Poorly controlled pain in the postoperative period negatively affects patient outcomes. Dexmedetomidine is a highly selective α2 adrenoceptor agonist with demonstrated analgesic efficacy. However, conflicting results have been reported in the current literature regarding the efficacy of dexmedetomidine in this surgery. In this study, we tested the hypothesis that dexmedetomidine safely improves pain scores and reduces opioid consumption in lumbar microdiscectomy.

Materials and methods: Medical records of patients who underwent lumbar microdiscectomy with general anesthesia between January 2023 and October 2023 were retrospectively reviewed. Patients who …

Cardiac Surgery Dilemmas: Evaluating Outcomes Of Sternotomy Versus Thoracotomy, Muhammet Fethi̇ Sağlam, Emrah Uguz, Kemal Eşref Erdogan, Hüseyi̇n Ünsal Erçeli̇k, Murat Yücel, Mete Hidiroglu, Erol Şener

Turkish Journal of Medical Sciences

Background/aim: This retrospective study aimed to compare the clinical outcomes, including reoperation rates, mortality, and valve size measurements, in patients undergoing sternotomy and thoracotomy for cardiac surgery, particularly focusing on tricuspid valve replacements. The study sought to highlight differences in surgical approaches and their impact on patient outcomes.

Materials and methods: A total of 107 patients were included, with 82 undergoing sternotomy and 25 undergoing thoracotomy. Preoperative right ventricular function parameters (mean pulmonary artery pressure, tissue Doppler imaging, and tricuspid annular plane systolic excursion), valve sizes, and other clinical data were recorded. Statistical analyses were performed to assess differences in …

Evaluation Of Treatment Compliance In Gout Patients: A Patient-Centered Study, Murat Buğra Görgülü, Riza Can Kardaş, Di̇lara Koç Şeramet, Ridvan Mercan, Mehmet Engi̇n Tezcan, Hami̇t Küçük, Abdurrahman Tufan, Berna Göker, Mehmet Aki̇f Öztürk

Turkish Journal of Medical Sciences

Background/aim: Most studies on unsuccessful gout treatment suggest that knowledge gaps and inadequate physician interventions are major contributors. However, there is a lack of research on the extent to which patients, educated by knowledgeable and experienced physicians, adhere to these recommendations.

Materials and methods: This study evaluated patients seen in university rheumatology clinics who were adequately informed about diet, target serum uric acid levels, and gout by rheumatologists. We assessed their compliance with treatment, clinical and laboratory findings, and disease status a median of seven years after treatment initiation. A total of 302 gout patients who began treatment in tertiary …

Procedural And Patient-Related Factors Play Differential Roles In The Postdural Puncture Headache, Ece Yanik, Doğa Vuralli, Tuğba Tunç

Turkish Journal of Medical Sciences

Background/aim: The incidence of postdural puncture headache varies depending on the multifactorial nature of the risk factors. Patient-related and procedure-related risk factors are still controversial. In this prospective observational study, we aimed to evaluate the risk factors for postdural puncture headache, the effect of previous headache features on the development of postdural puncture headache, and the risk factors for the immediate or delayed postdural puncture headache.

Materials and methods: We prospectively analyzed 116 patients who underwent lumbar puncture for diagnostic or therapeutic purposes. All clinical and laboratory findings, previous headache history, and the features and information related to the lumbar …

Benzyl Alcohol Improves Ang Ii-Induced Vascular And Renal Injury, Qi Hua, Zhenyu Gu

Turkish Journal of Medical Sciences

Background/aim: The etiology of hypertension in pediatric populations is complex and multifactorial, with metabolic abnormalitiesplaying a fundamental role in the pathogenesis of the condition. This study investigates the therapeutic effects of Benzyl alcohol (BA),identified through metabolomics analysis of pediatric hypertension serum, on Angiotensin II (Ang II)-induced vascular and renalinjury in murine models.

Materials and methods: Male C57BL/6 mice were used to establish a vascular remodeling model by continuous 4-week Ang II infusionusing a subcutaneous osmotic pump. Bioinformatics was used to identify target metabolites. The tail artery, common carotid arterydiastolic, and systolic pressures in mice were determined with a blood pressure …

Asynchronous Development Of The Mouse Auditory Cortex Is Driven By Hemispheric Identity And Sex, Ashlan P Reid, Demetrios Neophytou, Robert Levy, Cody Pham, Hysell V Oviedo

2020-Current year OA Pubs

Lateralized auditory processing is essential for specialized functions such as speech processing, typically dominated by the Left Auditory Cortex (ACx) in humans. Hemispheric specializations also occur in the adult mouse ACx, but their developmental origins are unclear. Our study finds that the Left and Right ACx in mice reach developmental milestones at different ages. Thalamocortical responses and maturation of synaptic dynamics develop earlier in the Right ACx than the Left. We show that this timing offset predicts hemisphere-dependent differences in sensory-driven plasticity. Juvenile tone exposure at specific times results in imbalanced adult tone frequency representations in the Right and Left …

The Essential Calcium Channel Of Sperm Catsper Is Temperature-Gated, Dilip K Swain, Citlalli Vergara, Júlia Castro-Arnau, Polina V Lishko

2020-Current year OA Pubs

The flagellar calcium channel CatSper is essential for male fertility, as it regulates calcium influx to trigger the hyperactive motility required for sperm to fertilize the egg. Precise activation of CatSper is critical, as premature activation can impair sperm function. While optimal temperature is known to influence fertilization, its effect on CatSper remains unknown. By directly recording from mouse spermatozoa, we reveal that CatSper functions as a temperature-gated ion channel, with a thermal threshold of 33.5 °C and a temperature coefficient Q

Kenyon College - April 17, 2025

The Kenyon Collegian

No abstract provided.

2025-04-17 Pac-3 Emeritus/Emeriti Status For Faculty - Revisal, Morehead State University. Faculty Senate.

Faculty Senate Records

Proposed revisal for PAC-3 Emeritus / Emeriti status for faculty, submitted to the Faculty Senate on April 17, 2025.

2025-04-17 Draft Of Hb 424, Morehead State University. Faculty Senate.

Faculty Senate Records

Unofficial copy of House Bill 424 submitted to the Faculty Senate on April 17, 2025.

2025-05-01 Faculty Senate Meeting Minutes, Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate meeting minutes from April 17, 2025.

2025-04-17 Committee Feedback On Strategic Plan Results, Morehead State University. Faculty Senate.

Faculty Senate Records

Committee Feedback on Strategic Plan Results and Prompts for Thought brought before the Faculty Senate on April 17, 2025.

2025-04-17 Comments Made At The Executive Committee Meeting On Hb 424, Morehead State University. Faculty Senate.

Faculty Senate Records

Comments made at the Executive Committee Meeting on Kentucky House Bill 424 and submitted to the Faculty Senate on April 17, 2025.