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The Importance Of Being Earnest: A Costume Designer’S Process, James Hunter Rock

Johnny Carson School of Theatre and Film: Theses, Student Research, and Creative Work

This thesis is a comprehensive breakdown of the costume design process for Nebraska Repertory Theatre’s production of The Importance of Being Earnest by Oscar Wilde during the fall semester of 2024. The author logs the production’s processes in collaborating on the concept and aesthetic of the play to present the Victorian era story for a modern audience. In this thesis, insights into the costume designer’s conceptualization, research, previsualization, and final design process are explored, providing an in-depth look into the creation of characters that remain true to the director’s original vision while being engaging for contemporary theatre. The various challenges …

The Impact Of Norepinephrine Exposure On Microglia Il-1b Production, Mikyas Telahun, Meah Katz, Kristy Bagley

Research and Creativity Symposium

Neuroinflammation, driven by proinflammatory cytokines, is linked to Alzheimer’s Disease (AD). Norepinephrine (NE) activates microglial adrenergic receptors, potentially increasing IL-1β production. This study investigates the effects of NE exposure on IL-1β production in human microglial cells, using adrenergic receptor-specific antagonists to isolate the effects of α1-AR, α2-AR, β2-AR, and combined α1& β2 -AR pathways. Microglia were treated with 100nM antagonists and exposed to control (0μM), medium (1 μM) or high (10 μM) NE concentrations. Media was collected at 3, 6 and 9 days, and protein content was standardized using a BioRad Protein Assay. IL-1β levels were quantified via ELISA (Sigma). …

Selection Of Therapeutically Effective T-Cell Receptors From The Diverse Tumor-Bearing Repertoire, Leonie Rosenberger, Naresha Saligrama, Et Al.

2020-Current year OA Pubs

BACKGROUND: The development of T-cell receptor (TCR)-based T-cell therapies is hampered by the difficulties in identifying therapeutically effective tumor-specific TCRs from the natural repertoire of a patient's cancer-specific T cells.

METHODS: Here, we mimic experimentally near-patient conditions to analyze the T-cell repertoire in euthymic tumor-bearing mice responding to the H-2K

RESULTS: We found that mp68-specific TCRs isolated from either tumor-infiltrating T cells or spleens of mice immunized with mp68-expressing cancer cells are diverse and not inherently therapeutic when introduced into peripheral T cells and used for adoptive therapy of established tumors. While measuring short-term T-cell responses in vitro was unreliable …

Mrn-Ctip, Exo1, And Dna2-Wrn/Blm Act Bidirectionally To Process Dna Gaps In Parpi-Treated Cells Without Strand Cleavage, Isabelle M Seppa, Mithila Tennakoon, Jessica Jackson, Celia D Rouault, Sumedha Agashe, Vladislav O Sviderskiy, Mangsi Limbu, Erica Lantelme, Alice Meroni, Priyanka Verma, Alessandro Vindigni, Et Al.

2020-Current year OA Pubs

Single-stranded DNA (ssDNA) gaps impact genome stability and PARP inhibitor (PARPi) sensitivity, especially in BRCA1/2-deficient tumors. Using single-molecule DNA fiber analysis, electron microscopy, and biochemical methods, we found that MRN, CtIP, EXO1, and DNA2-WRN/BLM resect ssDNA gaps through a mechanism different from their actions at DNA ends. MRN resects ssDNA gaps in the 3'-to-5' direction using its pCtIP-stimulated exonuclease activity. Unlike at DNA ends, MRN does not use its endonucleolytic activity to cleave the 5'-terminated strand flanking the gap or the ssDNA. EXO1 and DNA2-WRN/BLM specifically resect the 5' end of the gap independent of MRN-CtIP. This resection process alters …

Ud In The News April 26-May 2, University Of Dayton

News Releases

Experts continued to discuss the papal transition with appearances on Fox News, among others. Legal expert Charles Russo wrote for The Conversation and talked to Alabama Catholic Radio and National Catholic Reporter about a U.S. Supreme Court case.

Characterization Of Contributors To Pleural Fluid Viscosity, Yujai Lin, Megan Rushmeyer, Christopher G. Roy, Shannon Donovan, Rachel Cutting, Matthew Buttarazzi, Charlotte Crist, Ted Sears, J B. Zuckerman

Costas T. Lambrew Research Retreat 2025

Background: Pleural effusion is a common consequence of pulmonary disease and may result from a spectrum of conditions. This pilot study seeks to describe relationships between pleural fluid viscosity and fluid analytes commonly measured in clinical laboratories.

Pharmacist-Led Statin Initiation In Adults With Diabetes At An Adult Internal Medicine Clinic, Kevin Le, Michael Takach, Linh Gagnon, Dylan Atchley

Costas T. Lambrew Research Retreat 2025

Purpose: Implement and evaluate a pharmacist-led program addressing the current underutilization of statins among these high-risk patients with diabetes

Physical Activity Programming To Improve Qol In Pediatric Ibd Patients, George Russell, Anya K. Cutler, Anna Furr, Julia Fritz, Kevin Sztam, Birgitta Polson, Rebecca Edwards, Noah Hoffman

Costas T. Lambrew Research Retreat 2025

Discussion: This work contributes to limited literature supporting the positive impact of PA in a target population and provides novel guidelines to implement an accessible PA program proven to be effective and well-liked by patients & families. Findings support incorporation of PA into the holistic care of pediatric patients with IBD.

Mental Health Conditions Among Patients With A Disorder Of The Gut-Brain Interaction, Ambia Ahmed, Nicole Smith, Anya Cutler, Mariaelena Terzis, Laura J. Faherty, Julia Fritz

Costas T. Lambrew Research Retreat 2025

Two thirds of pediatric patients with disorders of the gut-brain interaction have mental health comorbidity.

Clinician Comfort, Attitudes, And Practices With Provision Of Harm Reduction Supplies To Patients Who Use Drugs, Amanda Cahn, Melissa Calica, Erin Mooz, Malia Haddock, Wendy Craig, Tania Strout, Kinna Thakarar

Costas T. Lambrew Research Retreat 2025

Over 100,000 individuals in the United States died from drug overdose in 2022, over 80,000 of which involved opioids. Overdose deaths from psychostimulants (cocaine, methamphetamine) have also been on the rise.

There has also been an increase in substance-related emergency department visits and hospitalizations. People who use drugs (PWUD) often have longer hospital stays, higher self-discharge, and readmission rates.

Laying The Groundwork: Implementing The 2021 Aap Well Appearing Febrile Infant Clinical Practice Guideline Across A Rural Health System, E Freeman, L Mallory, Lm Seften, T Palnitkar, A Cutler, J Gregory, M Jackson

Costas T. Lambrew Research Retreat 2025

The American Academy of Pediatrics (AAP) published their first-ever Clinical Practice Guideline (CPG) on the management of well-appearing febrile infants aged 8-60 days in 2021. A system specific CPG and order set for the management of well-appearing febrile infants has been published across MaineHealth (MH) to align with the AAP.

Factors Influencing No Show Rates In Adult Urology Patients, Bruce T. Ndebanje, Ethan Griffin, Evelyn James, Lily C. Wang

Costas T. Lambrew Research Retreat 2025

Our study highlights a strong association between insurance status and no-show rates. Patients with Medicaid or no insurance were significantly more likely to miss appointments (OR 3.25 and 5.99).

Test-Retest Agreement And Reliability Of Psychosis And Mental Health Screens For Maine Adolescents And Young Adults In Primary Care, Erika Mayer, Eb Bernier, Merelise Ametti, Julia Plumb, Adriana Lovric, Yaerin Wallenberger, Kristen Woodberry

Costas T. Lambrew Research Retreat 2025

Psychotic spectrum disorders are among the most severe mental health conditions. Although early intervention can lead to significantly improved outcomes, minimizing delays in the identification of psychotic spectrum symptoms (PSS) remains challenging.

Implementation And Evaluation Of A Resident Pediatric Complex Care Education Series, Calivin Schaffer, Danielle Doctor, Amy Buczkowski, Bonnie Lynne Boomsma, Logan Murray

Costas T. Lambrew Research Retreat 2025

Children with medical complexity have significant chronic health problems that affect multiple organ systems and result in functional limitations, high health care need or utilization, and often dependence on medical technology. Addressing their needs requires optimizing care within the medical home and medical neighborhood.

Evaluation Of Engagement And Collaboration Among Hospitals In The Maine Rural Maternity & Obstetrics Management Strategies (Rmoms) Network, Molly Volt, Lori Travis, Caroline Zimmerman, Erica Swan, Katherine Crothers, Anna Gilbert, Kate Allerding

Costas T. Lambrew Research Retreat 2025

Introduction

• Maine RMOMS Network: Grant awarded to Maine in 2022, 16 rural birthing hospitals & 5 state partners

• Network Goal: Improve access to maternity and obstetrics care for rural communities

• A qualitative Network Health Evaluation was conducted to diagnose strengths and areas of growth regarding engagement and collaboration

Infective Endocarditis In The Overdose Crisis: Addiction Care And Healthcare Utilization, Eva J. Farkas, Victoria Molina, Brittany Mohoney, Wendy Craig, Amy Mcauliffe, Kinna Thakarar

Costas T. Lambrew Research Retreat 2025

What is the impact of the IMAT program on healthcare utilization and addiction care outcomes following admissions for IDU-IE?

Community Health Workers: Putting "Community" In The Mainehealth Vision, Tim Cowan, Barbara Ginley, Leeanna Lavoie, Jennifer Maillet, Jemma Penberthy, Lori Travis

Costas T. Lambrew Research Retreat 2025

Community Health Workers (CHW) play an increasingly key role across the MaineHealth system. The integration of CHWs and growth of the workforce enhances care and improve patient engagement and outcomes. Utilizing data from FY24, modelling from the MH CHW Work Group as well as patient feedback, this poster illustrates the impact CHWs are having on the lives of patients, the care teams they support and the communities in which they live, work and play.

Improving Mainehealth Behavioral Health Non-Clinical Staff Knowledge And Comfort To Ask About Suicide With Question, Persuade, Refer (Qpr) Training, Hannah Pelletier, Julie Perron

Costas T. Lambrew Research Retreat 2025

No abstract provided.

Rigid Sternal Fixation Alone Does Not Result In A Reduction In Postoperative Opiod Administration Following Cardiac Surgery, Jane Branch, Chinedu Okoli, Kyla Wigant, Jaime Rabb, Robert S. Kramer, Anne Hicks, Ansar Hassan

Costas T. Lambrew Research Retreat 2025

Background: Persistent postoperative pain, infection, and sternal dehiscence are devastating complications after cardiac surgery that affect patient quality of life and increase healthcare system burden. Chronic sternal pain lasting more than 1 year affects 25 to 33% of cardiac surgery patients, and wound complications such as infection and sternal nonunion represent significant peri-operative risk factors1,2. Wire cerclage (WC) is the most widely accepted sternal closure technique among cardiac surgeons because of its perceived lower rates of sternal dehiscence, wound infection, and cost.

A Quality Improvement Project To Reduce Variation In Pediatric Asthma Care Using The Hospital Asthma Severity Scoring (Hass) Tool, Sean Patterson, Leah-Marie Seften, Rachel Williams, Noah Diminick, Anne Coates, Laura Amar-Dolan

Costas T. Lambrew Research Retreat 2025

The aim of this project was to increase HASS score use to greater than 50%within one year and determine the impact of our interventions on the quality of asthma care and patient outcomes.

Parent Perspectives On Primary/Specialty Co-Management Of Pediatric Asthma, James Bohnhoff, Mike Kohut, Dana Schwartz, Darby Glenn, Anya Cutler, Elizabeth A. Jacobs

Costas T. Lambrew Research Retreat 2025

No abstract provided.

An Opt Out Tobacco Cessation Referral Process For A Cancer Care Network, Amy Litterini, David Spaulding, Tia Robbins, Brett Cropp, Lauren Couture

Costas T. Lambrew Research Retreat 2025

Opt out tobacco cessation referrals should be standard of care.

Impact Of Individual Team Members On Team Performance In A Longitudinal Neonatal Resuscitation Telesimulation Program, Allison Zanno, Anya K. Cutler, Micheline Chipman, Leah Mallory, Leah M. Seften, Tara Palnitkar, Mary Ottolini, Misty Melendi

Costas T. Lambrew Research Retreat 2025

Physician participation in interprofessional simulation program improves team adherence to neonatal resuscitation guidelines.

Implementation Of Momsim 2.0, Beth Gray, Micheline Chipman, Lauren Weller, Emily Watson, Sarah Austin, Tara Palniker, Leah Mallory

Costas T. Lambrew Research Retreat 2025

Rural birth units are facing BIG challenges. SIMULATION can help.

Shortage As A Catalyst For High-Value Care: Evaluation Of A Bloof Culture Stewardship Intervention Driven By Supply Chain Disruption, Lesley B. Gordon, Camille Ezran, Elizabeth Herrle, Christina Yen, Nicholas J. Mercuro, Daniel J. Diekema

Costas T. Lambrew Research Retreat 2025

Evaluate the impact of diagnostic stewardship interventions on repeat blood culture ordering in bacteremic patients during the 2024 BD Bactec™ blood culture bottle shortage.

Analysis Of Novice And Expert Rater Reliability For A Neonatal Resuscitation Program® Adherence Assessment Tool, Sophia Martens, Misty Melendi, Anya Cutler, Sierra Soghikian, Leah Marie Seften, Tara Palnitkar, Allison Zanno, Leah Mallory

Costas T. Lambrew Research Retreat 2025

An NRP Adherence Assessment Tool used to evaluate efficacy of a telesimulation neonatal resuscitation training program demonstrated strong interrater reliability with both expert and novice raters.

Work Hard, Play Hard: How Game-Based Learning Impacts Learner's Engagement And Satisfaction In Intern Academic Half-Day, Katelyn Chadwick, Lesley Gordon, Monica Thim, Nicole Hudak

Costas T. Lambrew Research Retreat 2025

Background: Gamification and game-based learning (GBL) is being incorporated into graduate medical education (GME) to augment the more traditional lecture-based format, with the goal of promoting an interactive learning environment that strengthens collaboration. Although some GME programs have adopted GBL, there is limited study on its effect on learners.

Iterative Simulation And Healthcare Failure Modes And Effects Analysis Improves Child Abduction Response Systems Over Four Years Of Testing In A Children's Hospital, Dani Bruno, Marissa Perry, Madison (Max) Doane, Jamie Fey, Micheline Chipman, Brian Richardson, Leah Mallory

Costas T. Lambrew Research Retreat 2025

Iterative Simulations Improve Child Abduction Unit Readiness.

Pediatric Asthma Subspecialty Referral Practices In Rural Maine, Paras Patnaik, John Dipalazzo, James Bohnhoff

Costas T. Lambrew Research Retreat 2025

Over 7.2 million children in the United States have asthma.

• >300,000 asthma-related ED visits & hospitalizations yearly
• Both PCP’s and pediatric asthma subspecialists (allergist/immunologists and pediatric pulmonologists) provide long-term asthma care

Momsim-A Simulation-Based Outreach Program To Maintain Team Readiness For Obstetrical Emergencies Across A Rural Health System, Lauren Weller, Micheline Chipman, Beth Gray, Becky Hunt, Emily Watson, Sarah Austin, Anya Cutler, Jeff Holmes, Leah Mallory

Costas T. Lambrew Research Retreat 2025

An in situ Obstetric Emergency Simulation Training Program increased interprofessional Labor and Delivery team member confidence across our rural health system.