Digital Commons Network^™

Psychometric Properties Of The Spanish Yale-Brown Obsessive-Compulsive Scale - Second Edition, Eric A Storch, Jessica Sc Cheng, Miranda Higham, Josselyn S Muñoz, Vanessa Zavala Cruz, Dayan Berrones, Diana P Obando, Jacey L Anderberg, Renee M Frederick, Vissente Tapia-Cuevas, Macarena Churruca Muñoz, Constanza Uribe Villar, Pablo R Moya, Marcos E Ochoa-Panaifo, Mayra C Martinez Mallen, Andrew D Wiese, Caitlin M Pinciotti, Melisa N Sagarnaga, Joseph F Mcguire, Ogechi C Onyeka, María B Moyano, Latin American Trans-Ancestry Initiative For Ocd Genomics (Latino), Brazilian Obsessive-Compulsive Spectrum Disorder Working Group (Gttoc), Wayne K Goodman, James J Crowley

Faculty, Staff and Students Publications

The Yale-Brown Obsessive-Compulsive Scale, Second Edition (Y-BOCS-II) is an evidence-based clinician-rated measure for assessing the presence and severity of obsessive-compulsive symptoms. The Spanish version of the Y-BOCS-II has not yet been validated. The present study examines the psychometric properties of the Spanish Y-BOCS-II (Spanish-Y-BOCS-II) in adults with obsessive-compulsive disorder (OCD) who are of Hispanic/Latino ancestry. The Spanish-Y-BOCS-II was administered to 1805 adults with OCD. Participants also completed a battery of measures assessing OCD, depression, and anxiety symptoms. The internal consistency for the Symptom Checklist (Kuder-Richardson-20=0.92), Obsession Severity (α=0.87), Compulsion Severity (α=0.86), and Total Severity (α=0.92) were high. The inter-rater reliability …

Do Government Benefit Programs Reduce Child Labor?: Causal Evidence From The Midday Meal Scheme In India, Vardaan Chawla, Tomoki Fujii, Arpita Khanna, Ray Rohan

Research Collection School Of Economics

This study evaluates the impact of the midday meal program in India on the prevalence of child labor for upper primary school going children. The staggered implementation of the largest school feeding program in the world across states provides exogenous variation in exposure. Using the nationally representative National Sample Survey Office (NSSO) data, we find that exposure to the program reduced prevalence of child labor by 47 percent relative to children in never-treated states, with no significant difference in impact between boys and girls. The effects were primarily driven by a decline in household labor supply, especially performance of household …

The Gender Effects Of Covid: Evidence From Equity Analysts, Frank Weikai Li, Baolian Wang

Research Collection Lee Kong Chian School Of Business

We use COVID-19 and sell-side analysts as an experiment to study the effects of gender on labor productivity. We find that the forecast accuracy of female analysts declined more than that of male analysts, especially when schools were closed and among analysts who were more likely to have young children, were inexperienced, were busier, or lived in southern states of the US. Relative to male analysts, females also reduced their forecast timeliness and resorted to more heuristic forecasts but did not reduce coverage or updating frequency. Relative to pre pandemic, female analysts’ careers were more negatively affected than male analysts’. …

Us Food Waste, Kawika Barry

Sustainable Supply Chain Management

This essay touches on the food waste problem we have in the US and various ways to help reduce the issue at hand.

Analyzing The Dihedral Scattering Component Of P-Band Sar Signals For Trunk Permittivity Estimation – A Concept Study, Anke Fluhrer, Hamed Alemohammad, Thomas Jagdhuber

Geography

A new retrieval method, based on a hybrid decomposition technique and the extended (x-) Fresnel model, is proposed for estimating trunk permittivity from polarimetric P-band SAR observations. P-band SAR observations of NASA's Airborne Microwave Observatory of Subcanopy and Subsurface (AirMOSS) mission campaign are employed to test the proposed retrieval method at individual measuring stations across the U.S. between 2013 and 2015. In order to test the feasibility of the x-Fresnel model for such analyses and its sensitivity to required input parameters, a detailed sensitivity study revealed that at P-band frequencies there is a need to account for scattering losses, phase …

Aeroallergen Exposure As Short-Term Predictor Of Respiratory Viral Infections In Two Health Regions (Caguas And San Juan) In Puerto Rico: A Seasonal And Machine Learning Approach, Félix E. Rivera-Mariani, Armando J. Borrero-Aponte, Benjamín Bolaños-Rosero

Faculty and Staff Publications & Presentations

In this late-breaking abstract, we investigated whether seasonal and short-term variations in airborne fungal spores and pollen are associated with, and predictive of, influenza and COVID-19 incidence in the San Juan and Caguas health regions of Puerto Rico from 2022 to 2024. Using correlation analyses, lag modeling, logistic regression, and machine learning approaches, the study found that fungal spore concentrations—but not pollen—were consistently associated with and predictive of high-incidence influenza and COVID-19 days, particularly during the fall season. Peak associations occurred at short lags of 2–4 days, and random forest models demonstrated strong predictive performance for both influenza and COVID-19 …

Cardiovascular And Renal Treatment In Heart Failure Patients With Hyperkalemia Or High Risk Of Hyperkalemia: Rationale And Design Of The Care-Hk In Hf Registry, Stephen J Greene, Michael Böhm, Biykem Bozkurt, Javed Butler, John G F Cleland, Andrew J S Coats, Nihar R Desai, Diederick E Grobbee, Ellie Kelepouris, Fausto Pinto, Giuseppe Rosano, Isabelle Morin, Peter Szecsödy, Solenn Fabien, Sandra Waechter, Maria G Crespo-Leiro, Martin Hülsmann, Tibor Kempf, Otmar Pfister, Anne-Catherine Pouleur, Andrew J Sauer, Manish Saxena, Martin Schulz, Maurizio Volterrani, Stefan D Anker, Mikhail N Kosiborod

Faculty, Staff and Students Publications

Background: Despite guideline recommendations, many patients with heart failure (HF) do not receive target dosages of renin-angiotensin-aldosterone system inhibitors (RAASis) in clinical practice due, in part, to concerns about hyperkalemia (HK).

Methods and results: This noninterventional, multinational, multicenter registry (NCT04864795; 111 sites in Europe and the USA) enrolled 2558 eligible adults with chronic HF (mostly with reduced ejection fraction [HFrEF]). Eligibility criteria included use of angiotensin-converting-enzyme inhibitor/angiotensin-II receptor blocker/angiotensin-receptor-neprilysin inhibitor, being a candidate for or treatment with a mineralocorticoid receptor antagonist, and increased risk of HK (eg, current serum potassium > 5.0 mmol/L), history of HK in the previous …

Detection Of Enterovirus Rna In Pancreas And Lymphoid Tissues Of Organ Donors With Type 1 Diabetes, Jutta E Laiho, Sami Oikarinen, Sofia Morfopoulou, Maarit Oikarinen, Ashlie Renner, Daniel Depledge, Matthew C Ross, Ivan C Gerling, Judith Breuer, Joseph F Petrosino, Vincent Plagnol, Alberto Pugliese, Antonio Toniolo, Richard E Lloyd, Heikki Hyöty, Npod-Virus Group

Center for Medical Ethics and Health Policy Staff Publications

Aims/hypothesis: The nPOD-Virus group collaboratively applied innovative technologies to detect and sequence viral RNA in pancreas and other tissues from organ donors with type 1 diabetes. These analyses involved the largest number of pancreas samples collected to date. The aim of the current work was to examine the presence of enterovirus RNA in pancreas and lymphoid tissues of organ donors with and without type 1 diabetes.

Methods: We analysed pancreas, spleen, pancreatic lymph nodes and duodenum samples from the following groups: (1) donors with type 1 diabetes (n=71) with (n=35) or without (n=36) insulin-containing islets; (2) donors with single or …

Quality Of Life And Patient Experience In Black Women With Alopecia, Annyella Douglas, Jayson Suriano, Neda Nikbakht

Department of Dermatology and Cutaneous Biology Faculty Papers

No abstract provided.

The Pricing Of Green Bonds And The Determinants Of The Green Bond Premium In The Asia-Pacific And European Markets, Parath Wongaree, Chiyachantana N. Chiraphol, Kuan Yong David Ding, Pattarawan Prasarnphanich, Wasin Siwasarit

Research Collection Lee Kong Chian School Of Business

This study examines the sources of capital for sustainable development and investigates the existence of a green bond premium in both primary and secondary bond markets across the Asia-Pacific and European regions. Utilizing the robust Coarsened Exact Matching (CEM) method in conjunction with the Synthetic Minority Oversampling Technique (SMOTE), our analysis reveals a significant disparity in yields between green bonds and conventional bonds within the Asia-Pacific markets, indicating the existence of a green bond premium. In contrast, this distinction is not observed in Europe. These findings suggest that investors in the Asia-Pacific region display a willingness to accept lower yields …

Business Schools And The External Environment: Where Are They Now?, Kai Peters, Howard Thomas, Michael Thomas

Research Collection Lee Kong Chian School Of Business

The article, the first of a two-part series, takes a look at the external environment facing business schools today. Major factors considered include the global landscape and related populism, funding shortfalls, increasing regulatory burdens, increased competition, and artificial intelligence. This combination of challenges, together with factors that are internal to business schools and universities and will be examined in an article later in the year, means that it is not an easy time to be the dean of a business school. Protecting present income streams, developing new sources of funds, and being agile are all paramount.

Efficient Bilateral Trade With Interdependent Values: The Use Of Two-Stage Mechanisms, Takashi Kunimoto, Cuiling Zhang

Research Collection School Of Economics

Efficient, voluntary bilateral trades are generally not implementable in an interdependent values environment with two-sided asymmetric information. To obtain more positive results, we consider two-stage mechanisms in which (i) the outcome (e.g., allocation of the goods) is determined first; (ii) the agents partially learn the state via their own outcome-decision payoffs; and (iii) transfers are finally made. We propose the approximate shoot-the-liar (AS) mechanism and identify Assumption 1, under which “approximately” efficient, voluntary trades are implementable. We further illustrate the permissiveness of the assumption, and characterize it in terms of the nature of interdependence in valuation functions—delineating the boundary between …

Harnessing Redox-Active Molecules In Alkylammonium Halide-Based Eutectic Solvents For Redox Flow Batteries, Zeru Syum, Jesse Wainright, Desiree Mae Prado, Burcu Gurkan, Palani Sabhapathy, Clemens Burda, Matthew Vasil, Robert Savinell

Faculty Scholarship

Redox flow batteries (RFBs) are promising for large-scale energy storage, however, advancements in performance and cost-effectiveness are critical factors for adoption. Here we report on alkylammonium halide based eutectic solvents (ESs) and found that a ESs comprising of diethylammonium chloride or bromide, in ethylene glycol demonstrated exceptional stability and a wide electrochemical stability window, making it a promising candidate for RFB applications. The electrochemical stability and redox behavior of the alkylammonium halide-based ESs are significantly influenced by hydrogen-bonding interactions, modulated by the alkyl chain length of the cation and the nature of the anion. A redox-active eutectic electrolyte containing 0.45 …

Evaluation Of Gold Helical Microwire Structure Electrode For Long-Term Rodent Nerve Stimulation, Danny V. Lam, Kevin Yang

Faculty Scholarship

Objective. The development of electrodes for chronic peripheral nerve stimulation faces several challenges, including complex compositions, intricate manufacturing processes, and high costs associated with the availability and fabrication of suitable materials. These limitations hinder the accessibility and feasibility of producing effective devices for chronic preclinical studies. This study evaluated the feasibility of a simple-to-manufacture gold helical microwire structure electrode (Au-HMSE) for peripheral nerve stimulation, electromyography (EMG) recording, and preliminary tissue response on the rat sciatic nerve. Approach. Manufactured electrodes were used for up to 8 weeks in rats for nerve stimulation and EMG recordings, with electrode-tissue impedances and motor thresholds …

Measuring The Relationship Between Oil Revenues And The Parallel Exchange Rate In Iraq For The Period (2003-2023): An Empirical Study, Saif Nihad Salim, Safaa Ali Hussein Al-Bakri

Journal of Economics and Administrative Sciences

This study is an empirical investigation into the relationship between oil revenues and the parallel exchange rate in Iraq during the period from 2003 to 2023, highlighting the susceptibilities of a rentier economy dependent overwhelmingly on oil exports. The study adopted a deductive procedure coupled with econometric analysis using the Autoregressive Distributed Lag (ARDL) method to analyze the impacts of oil revenues and GDP without oil on the parallel exchange rate. Annual data were gathered from official Iraqi agencies and subjected to unit root tests, bounds cointegration tests, and error correction model (ECM) tests. The results indicate a statistically significant …

Strategic Monitoring And Its Impact On Organizational Sustainability: An Analytical Study In Baghdad Health Directorates (Karkh, Rusafa, And Medical City), Rawad Ali Rahal, Suheir Adel Hamed

Journal of Economics and Administrative Sciences

This paper analyzes how Strategic Monitoring (SM) affects the Organizational Sustainability (OS) of some selected Baghdad Health Directorates in Iraq and attempts to establish how economic, social, and environmental sustainability can be achieved through SM, which includes strategic intelligence, strategic thinking, and strategic vigilance. A descriptive-analytical methodology has been used in which data was gathered using a structured questionnaire administered to 60 middle management officials of the directorates. The data were processed through suitable statistical tools using regression and correlation methods with the help of SPSS software. Results indicate that there exists a strong and significant positive relationship between SM …

Analysis Of The Vicious Circle Of Education And Its Impact On Human Development In Iraq, Walaa Ibrahim Hussein, Lawrence Yahiya Saleh Al- Kubaisi

Journal of Economics and Administrative Sciences

This research focuses on the complex relationship between education quality and human development in Iraq for 2005 to 2023, emphasizing how the poor conditions in education set in place a vicious circle restricting national progress. Utilizing both inductive and deductive realms, official data of the Ministries of Education and Planning were analyzed, along with comparative international experiences. Indicators analyzed include school density, student-teacher ratio, lack of infrastructure, and limitations of vocational training for primary, secondary, and vocational educational levels. The results show a constant mismatch between students' population growth and resource allocation to education, thus summarizing an overcrowded school environment, …

Neuroticism Predicts Constructive Conflict Resolution Styles In Conscientious Individuals: Evidence From Self-Reports And Observer Ratings, Frosch Yi Xuan Quek, Hwajin Yang, Andree Hartanto

Research Collection School of Social Sciences

The ability to resolve conflict is crucial for maintaining healthy relationships and psychological well-being. However, prior research has often overlooked the potential benefits of neuroticism for conflict resolution styles, due to a reliance on self-report measures and the lack of consideration of healthy neuroticism. This study examined the relationship between neuroticism and conflict resolution styles and highlights the pivotal role of conscientiousness and measurement modalities. Employing both self-reports and observer ratings of the Conflict Resolution Styles Inventory (CRSI), we analyzed data from young adults (N = 259) using structural equation modeling analysis. Self-reports indicated that neuroticism was associated with unconstructive …

Deconstructing The Extended Focused Assessment With Sonography In Trauma (E-Fast) As A Roadmap For Longitudinal Integration Of Point Of Care Ultrasound Education Within Undergraduate Medical Education, Cherie Tator, Maria Maldonado, Nadia Ismail, Kiyetta H Alade, Alan Riley

Faculty and Staff Publications

Point-of-care ultrasound (POCUS) has been embraced by most medical specialties, yet undergraduate medical education still has difficulty incorporating POCUS skill development and assessment. While much of the existing literature focuses on specific POCUS and/or ultrasound topics, the feasibility as well as ensuring POCUS topics are relevant to all undergraduate medical education (UME) learners are often left unaddressed. The authors outline a novel, outcomes-driven, longitudinal POCUS curriculum designed around a "deconstructed" Extended Focused Assessment with Sonography in Trauma (E-FAST) exam, which facilitated purposeful integration of POCUS and medical imaging topics into organ system-based foundational courses. Curriculum development strategies specific to POCUS …

International Society For Cell & Gene Therapy Expanded Access Working Group Position Paper: Key Considerations To Support Equitable And Ethical Expanded Access To Investigational Cell- And Gene-Based Interventions, Elena Maryamchik, Laertis Ikonomou, Beth E Roxland, Felix Grignon, Bruce L Levine, Bambi J Grilley

Center for Medical Ethics and Health Policy Staff Publications

This position paper reviews the Expanded Access pathway for cell and gene therapies, examining its critical role at the nexus of patient need, regulatory frameworks, and scientific advancement. Spearheaded by the International Society for Cell & Gene Therapy's Expanded Access Working Group, it explores how investigational therapies are accessed outside of clinical trials for patients with serious or life-threatening conditions when no approved alternatives exist. Access to cell and gene therapy products are of specific interest to patients because many times the products are bespoke, being used to treat serious and/or incurable conditions, and are potentially curative. As the field …

Joint Analysis Of The Npod-Virus Group Data: The Association Of Enterovirus With Type 1 Diabetes Is Supported By Multiple Markers Of Infection In Pancreas Tissue, Sarah J Richardson, Teresa Rodriguez-Calvo, Jutta E Laiho, John S Kaddis, Julius O Nyalwidhe, Irina Kusmartseva, Sofia Morfopoulou, Joseph F Petrosino, Vincent Plagnol, Kathrin Maedler, Margaret A Morris, Jerry L Nadler, Mark A Atkinson, Matthias Von Herrath, Richard E Lloyd, Heikki Hyoty, Noel G Morgan, Alberto Pugliese, Npod-Virus Group

Center for Medical Ethics and Health Policy Staff Publications

Aims/hypothesis: Previous pathology studies have associated enterovirus infections with type 1 diabetes by examining the enterovirus capsid protein 1 (VP1) in autopsy pancreases obtained near diabetes diagnosis. The Network for Pancreatic Organ Donors with Diabetes (nPOD) has since obtained pancreases from organ donors with type 1 diabetes (with broad age and disease duration) and donors with disease-associated autoantibodies (AAbs), the latter representing preclinical disease. Two accompanying manuscripts from the nPOD-Virus Group report primary data from a coordinated analysis of multiple enterovirus indices. We aimed to comprehensively assess the association of multiple enterovirus markers with type 1 diabetes.

Methods: The nPOD-Virus …

Exploring Teacher Behaviors That Support Student Self-Regulated Learning In The Clinical Environment, Stephanie B Corliss, Emily K Vinas, Andrew D Bergemann, Jonathan A Macclements, Elizabeth A Nelson

Faculty and Staff Publications

Introduction: With rapidly evolving clinical practice and medical knowledge, future doctors must be independent lifelong learners. Self-regulated learning (SRL) represents a formalized approach to lifelong learning, involving cycles of planning, learning, assessment, and adjustment. Medical schools can create clinical environments where learners are instructed in SRL and encouraged to routinely practice using it. Clinical educators can provide guidance in SRL by co-regulating learning with students. The purpose of this study is to explore how clinical teachers co-regulate the learning process with students during clinical clerkships.

Methods: Data was analyzed from student evaluations of clinical teaching faculty and residents during clinical …

Implementing A Pre-Matriculation Program Targeting Self-Efficacy, Institutional Belongingness, And Metacognition, Steve Caloudas, Nital Appelbaum, Jesus Vallejo, Nadia Ismail, Andrea Stolar

Faculty and Staff Publications

Students come to medical school with diverse backgrounds and experiences. Accordingly, many schools have developed pre-matriculation programs to support students' transition into medical education, especially for those whose educational path may not have offered the same breath of opportunities as their incoming counterparts. Baylor College of Medicine established a pre-matriculation program for students from early assurance programs and non-traditional pathways to address gaps in student support and normalize help-seeking behavior. This program took place over 2 weeks and was developed with leadership and student partners. Participants included 21 students who completed baseline and post-program surveys. Results indicated that a focus …

Histologic- And Genomic-Directed Adjuvant Therapy For Ampullary Adenocarcinoma: A Hidden Genome-Derived Analysis, Brett L Ecker, Kenneth Seier, Ankur Choubey, Austin M Eckhoff, Gabriella N Tortorello, Vinod P Balachandran, Nicola Blackburn, Michael I D'Angelica, Ronald P Dematteo, Daniel G Blazer, Jeffrey A Drebin, William E Fisher, Anthony J Gill, Marie-Claude Gingras, T Peter Kingham, Major K Lee, Michael E Lidsky, Daniel P Nussbaum, Michael J Overman, Jaswinder S Samra, Ronglai Shen, Carlie S Sigel, Charles M Vollmer, Alice C Wei, Sabino Zani, Australian Pancreatic Genome Initiative, Robert E Roses, Mithat Gonen, William R Jarnagin

Faculty, Staff and Students Publications

Background: The benefit of adjuvant chemotherapy (AC) for ampullary adenocarcinoma is unclear. The Hidden Genome model classifies prognostic subtypes with greater accuracy than standard histologic classification (intestinal [INT] vs pancreatobiliary [PB]), but its predictive capacity to guide the use of AC remains unstudied.

Methods: We applied the Hidden Genome model to an international cohort of 183 patients with resected ampullary adenocarcinoma who underwent genomic sequencing. The model quantified the predicted cell of origin (colorectal vs pancreas/distal bile duct) in all specimens. Overall survival (OS) was compared using Kaplan-Meier estimates, stratified by AC use versus surgery alone (SA).

Results: Most patients …

Bile Acid Regulation Of Xenobiotic Nuclear Receptors On The Expressions Of Orosomucoids In The Liver, Ji Ho Suh, Inyoung Cheon, Hyun-Jung Jung, Sung Ho Lee, Mi Jeong Heo, Matthew Deberge, Clavia Ruth Wooton-Kee, Kang Ho Kim

Children’s Nutrition Research Center Staff Publications

The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are xenobiotic nuclear receptors activated by various xenobiotics, drugs, hormones, and bile acids (BAs). Upon activation, these nuclear receptors play critical roles in regulating systemic energy homeostasis. However, precise mechanisms through which CAR and PXR influence systemic metabolism remain incompletely understood. Here, we investigated the impact of CAR and PXR on the liver-secreted hormone (i.e., hepatokine) expressions in response to BA stress such as cholic acid (CA) feeding. Our analysis revealed that several BA-activated genes, including the well-known CAR/PXR target, aldo-keto reductase family 1, member B7 (Akr1b7 …

A Sumo-Interacting Motif In The Guanine Nucleotide Exchange Factor Epac1 Is Required For Subcellular Targeting And Function, Wenli Yang, Fang Mei, Wei Lin, Jason E Lee, Si Nie, Christopher J Bley, André Hoelz, Xiaodong Cheng

The Brown Foundation: Institute of Molecular Medicine

Exchange protein directly activated by cAMP (EPAC1), a multifunctional intracellular cAMP receptor, dynamically localizes to various cellular loci, engaging with diverse molecular partners to maintain cellular homeostasis. The study investigates the role of the SUMO-interacting motif (SIM) in the subcellular targeting and cellular functions of EPAC1. It reveals that the SIM is a critical structural element for EPAC1's association with RanBP2/nucleoporin 358, a nucleoporin of the cytoplasmic filament component of the nuclear pore complex. Mutational disruption of EPAC1 SIM interferes with EPAC1's ability to activate its canonical effectors, small GTPases, Rap1 and Rap2, and noncanonical functions, such as the formation …

Changes In The Fxr-Cistrome And Alterations In Bile Acid Physiology In Wilson Disease, Clavia Ruth Wooton-Kee, Hari K Yalamanchili, Islam Mohamed, Manal Hassan, Kenneth D R Setchell, Monica Narvaez Rivas, Ayse K Coskun, Vasanta Putluri, Nagireddy Putluri, Prasun Jalal, Michael L Schilsky, David D Moore

Children’s Nutrition Research Center Staff Publications

Background: Wilson disease (WD) is an autosomal recessive disorder that results in excessive hepatic copper, causing hepatic steatosis, inflammation, fibrosis, cirrhosis, and liver failure. Previous studies have revealed dysregulation of many farnesoid X receptor (FXR) metabolic target genes in WD, including the bile salt exporter pump, the major determinant of bile flow.

Methods: We tested the hypothesis that the FXR-cistrome is decreased in Atp7b-/- mice in accord with dysregulated bile acid homeostasis.

Results: FXR binding within Atp7b-/- mouse livers displayed surprising complexity: FXR binding was increased in distal intergenic regions but decreased in promoter regions in Atp7b-/- versus wild-type mice. …

A Meta-Analysis Of Diagnostic Yield And Clinical Utility Of Genome And Exome Sequencing In Pediatric Rare And Undiagnosed Genetic Diseases, Rajshree Pandey, Noemi Fluetsch Brennan, Kalliopi Trachana, Sarah Katsandres, Olaf Bodamer, John Belmont, David L Veenstra, Siyang Peng

Center for Medical Ethics and Health Policy Staff Publications

Purpose: To systematically evaluate the diagnostic yield and clinical utility of genome sequencing (GS) and exome sequencing (ES; genome-wide sequencing [GWS]) in pediatric patients with rare and undiagnosed genetic diseases.

Methods: We conducted a meta-analysis of studies published between 2011 and 2023. To address study heterogeneity, comparative analyses included within-cohort studies using random-effects models.

Results: We identified 108 studies including 24,631 probands with diverse clinical indications. The pooled diagnostic yield among within-cohort studies (N = 13) for GWS was 34.2% (95% CI: 27.6-41.5; I2: 86%) vs 18.1% (95% CI: 13.1-24.6; I2: 89%) for non-GWS, with 2.4-times odds of diagnosis (95% …

Promises And Pitfalls Of Preimplantation Genetic Testing For Polygenic Disorders: A Narrative Review, Jaime A Roura-Monllor, Zachary Walker, Joel M Reynolds, Greysha Rivera-Cruz, Avner Hershlag, Gheona Altarescu, Sigal Klipstein, Stacey Pereira, Gabriel Lázaro-Muñoz, Shai Carmi, Todd Lencz, Ruth Bunker Lathi

Center for Medical Ethics and Health Policy Staff Publications

Preimplantation genetic testing for polygenic disorders (PGT-P) has been commercially available since 2019. PGT-P makes use of polygenic risk scores for conditions which are multifactorial and are significantly influenced by environmental and lifestyle factors. If current predictions are accurate, then absolute risk reductions range from about 0.02% to 10.1%, meaning that between 10 and 5,000 in vitro fertilization patients would need to be tested with PGT-P to prevent one offspring from becoming affected in the future, depending on the condition and the number of embryos available. Survey and interview data reveal that patients and the public have largely favorable views …

Interacting Immediate And Long-Term Action Regulation In Suicidal Behavior, Nicholas Murphy, George Kypriotakis, Marijn Lijffijt, Sidra Iqbal, Tabish Iqbal, Dania Amarneh, Brittany O'Brien, Amanda Tamman, Ynhi Thomas, Nidal Moukaddam, Thomas R Kosten, Lynnette A Averill, Sanjay Mathew, Alan C Swann

Staff and Researcher Publications

Background: Suicide is a prominent cause of death across the lifespan, especially between 10 and 34 years old. Most suicides are first attempts, during crises with unpredictably fluctuating risk, arising insidiously from mechanisms related to long-term exposure to psycho-bio-social risk factors. Identifying susceptibility from interacting immediate and long-term mechanisms of action regulation could prevent suicidal crises.

Methods: We investigated interacting immediate and long-term regulation of action in risk for suicide. Immediate processes were assessed through affective and behavioral symptoms and a computer measure of impaired action-regulation, the Immediate Memory Task (IMT). Long-term processes included history of trauma, stress, and addictive …