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Building Bridges: Union Efforts To Address Stress Among Educational Staff, Theodore Michael Hamilton Jun 2025

Building Bridges: Union Efforts To Address Stress Among Educational Staff, Theodore Michael Hamilton

Dissertations

This mixed-methods study examines the relationship between administrative support and educator stress and burnout in a post-COVID unionized school district. Grounded in Bronfenbrenner’s Ecological Systems Theory, the Job Demands-Resources (JD-R) model, and the Transactional Model of Stress and Coping, the study surveyed 102 educational professionals and conducted semi-structured interviews with union delegates. Quantitative findings revealed that 75% of staff worked beyond contracted hours, and 63% assumed additional unpaid responsibilities. Lower levels of perceived administrative support were significantly correlated with higher burnout and greater intent to leave the profession. Qualitative thematic analysis identified key stressors, including inconsistent administrative communication, escalating student …


Through The Wire: Examining The Experiences Of Formerly Incarcerated Students In Prison Education Programs And The Wraparound Services Needed To Support Their Success, Isabel Castro Jun 2025

Through The Wire: Examining The Experiences Of Formerly Incarcerated Students In Prison Education Programs And The Wraparound Services Needed To Support Their Success, Isabel Castro

Dissertations

This qualitative study examines the experiences of formerly incarcerated individuals in Prison Education Programs (PEPs) and the wraparound services necessary to support their success. Through Schlossberg’s Transition Theory, this study explores how incarcerated students navigate educational transitions and how educators facilitate transformative learning. Using case study and narrative inquiry, interviews were conducted with fifteen formerly incarcerated PEP participants and seven educators.

Thematic analysis revealed six major themes: Access to Education in Carceral Settings, the Impact of Education on Incarcerated Individuals, Wraparound Services and Student Support, Experiences of Formerly Incarcerated Students, the Role of Educators and Program Facilitators, and Best Practices …


Schauder A Priori Estimates For Poisson's Equation., Janani P. Marasinghe Jun 2025

Schauder A Priori Estimates For Poisson's Equation., Janani P. Marasinghe

Research Papers

The Schauder a priori estimate for Poisson's equation is considered. These estimates are important for establishing the smoothness of solutions. Instead of proving the theorem of Schauder a priori estimate directly, this paper focuses on proving the theorem through three reductions. The first reduction normalizes the problem, the second reduction controls the H\"older semi-norm, and finally the third reduction gets a local estimate of the domain. Interpolation inequality for H\"older space and derivative estimates are used throughout this work.


Developing Machine Learning Models And Graphene-Based Flexible Humidity And Temperature Sensors For Machine-Learning-Assisted Sensing, Seth Hajian Jun 2025

Developing Machine Learning Models And Graphene-Based Flexible Humidity And Temperature Sensors For Machine-Learning-Assisted Sensing, Seth Hajian

Dissertations

Flexible sensor technology has recently gained tremendous momentum in both academic research and industrial applications, transitioning from conceptual frameworks to practical implementations across diverse fields. This remarkable advancement can be attributed to several converging factors, including the maturation of nanomaterial science, the advancements of machine learning algorithms, and the critical demand for intelligent sensing solutions in healthcare, environmental monitoring, and industrial automation. The growing emphasis on personalized medicine and real-time health monitoring, accelerated by global health challenges, has further highlighted the necessity for accurate, cost-effective, and adaptable sensing platforms. This dissertation presents the fulfillment of three interconnected research projects focused …


Final Silver Bow Creek Conservation Area (Sbcca) Butte Reduction Works (Brw) Air Monitoring For Interim Demolition Activities – Phase I Data Summary Report (Dsr), Pioneer Technical Services, Inc. Jun 2025

Final Silver Bow Creek Conservation Area (Sbcca) Butte Reduction Works (Brw) Air Monitoring For Interim Demolition Activities – Phase I Data Summary Report (Dsr), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


In Vitro Evaluation Of A Novel Computationally Designed Anticancer Peptide In Ovarian Cancer Cell Models, Basma A. Shaala Jun 2025

In Vitro Evaluation Of A Novel Computationally Designed Anticancer Peptide In Ovarian Cancer Cell Models, Basma A. Shaala

Theses and Dissertations

Ovarian cancer remains one of the leading causes of cancer-related mortality among

women, highlighting the need for novel therapeutic agents with improved selectivity and

reduced toxicity. Anticancer peptides (ACPs) have emerged as promising candidates

due to their ability to selectively target cancer cells. In this study, the anticancer activity

of a computationally designed ACP was evaluated in vitro using the SKOV-3 ovarian

cancer cell line, with HEK cells employed as a non-cancerous control.

Cell viability was assessed using the MTT assay, and cytotoxicity was further confirmed

by the trypan blue exclusion method. Apoptosis and necrosis were analyzed using

Annexin V-FITC/Propidium …


Load Balancing In Mobile Networks Using Deep Reinforcement Learning And Traffic Prediction, Shorouk Raafat Mokhtar Abouamasha Jun 2025

Load Balancing In Mobile Networks Using Deep Reinforcement Learning And Traffic Prediction, Shorouk Raafat Mokhtar Abouamasha

Theses and Dissertations

Wireless communication networks are advancing at a rapid pace, driven by various challenges and ambitious goals. This rapid growth is driven by a range of applications, including technologies like the Internet of Things (IoT), as well as innovations in smart cities, autonomous vehicles, and more. Different applications demand specific performance criteria such as high data throughput, low latency, robust reliability, and efficient energy usage. In this thesis, we investigate two enhancements that can be adopted in wireless networks to tackle the challenges of resource optimization and network management. The motivation behind this is the fact that future networks will face …


The Benefits And Pitfalls Of Public Private Partnerships: Case Study Of The Suez Canal Container Terminal, Egypt, Magda Elswesy Jun 2025

The Benefits And Pitfalls Of Public Private Partnerships: Case Study Of The Suez Canal Container Terminal, Egypt, Magda Elswesy

Theses and Dissertations

The study explores the public-private partnerships (PPPs) in constructing, managing, and operating container terminals in Egypt. It examines the benefits the public sector gains from such collaborations and the pitfalls that can be mitigated to foster more effective institutional cooperation. The study specifically focuses on enhancing Egypt's marine container terminals through these partnerships, emphasizing the potential use of growing technology to enable equipment automation. It also highlights concerns regarding the risk of mismanagement of Egyptian terminals, arising from insufficient expected volume to ensure appropriate profitability, especially with the opening of new terminals. The study adopts a qualitative methodology and presents …


From Drama To Change: The Role Of Female-Led Egyptian Tv Dramas In Tackling Women’S Issues And Inspiring Youth, Myrna Bader Jun 2025

From Drama To Change: The Role Of Female-Led Egyptian Tv Dramas In Tackling Women’S Issues And Inspiring Youth, Myrna Bader

Theses and Dissertations

The media is widely recognized as a powerful tool for driving social change, shaping public opinion, and influencing societal discourse. In Egypt, it has played a critical role in addressing women’s issues, including discrimination and societal challenges, by raising awareness and either reinforcing or challenging societal issues. This paper examines the impact of female-led Egyptian TV dramas in addressing women’s issues, specifically taboos, stereotypes, and personal status laws. The paper aims to examine their potential to raise awareness, challenge cultural norms, and inspire youth-driven social change. To achieve its objectives, three female-led Egyptian TV dramas addressing specific women’s societal issues …


Aging And The Law In Singapore And Japan: Adult Guardianship And Other Alternatives, Hang Wu Tang, Yukio Sakurai, Yue-En Chong Jun 2025

Aging And The Law In Singapore And Japan: Adult Guardianship And Other Alternatives, Hang Wu Tang, Yukio Sakurai, Yue-En Chong

Research Collection Yong Pung How School Of Law

Comparative adult guardianship law and other alternatives, especially in an Asian context, is an under-investigated area. This paper attempts to fill the gap in the literature by comparing the adult guardianship law and other alternatives from the perspectives of Singapore and Japan. The central argument of this paper is that in order for the law of adult guardianship to be widely adopted in Asian societies like Singapore and Japan - where much of adult guardianship related issues are governed by informal familial arrangements; this would require governments to do more than the mere enacting of adult guardianship legislation. To encourage …


Incidental Finding Of An Infarcted Epiploic Appendage Attached To The Sigmoid Colon, Ifeanyi K. Uche, Alec A. Hirsch Jun 2025

Incidental Finding Of An Infarcted Epiploic Appendage Attached To The Sigmoid Colon, Ifeanyi K. Uche, Alec A. Hirsch

School of Medicine Faculty Publications

Background: Epiploic appendagitis is a condition usually caused by infarction of the epiploic appendages, small outpouchings of adipose tissue found on the serosal surface of the colon. Epiploic appendagitis is a rare cause of acute lower abdominal pain, but the condition does not have any specific presenting clinical features and is often misdiagnosed as acute diverticulitis, appendicitis, or other gastrointestinal disorder. Case Report: A 53-year-old female presented with abnormal uterine bleeding and pelvic pain and was seeking definitive surgical management. During the patient’s total laparoscopic hysterectomy with bilateral salpingo-oophorectomy, an infarcted epiploic appendage attached to the sigmoid colon was found. …


Integrating Pedagogy And Mathematics Content In Content-Focused Professional Development, Liza Bondurant, Joey Rutherford, Shannon Sharp Jun 2025

Integrating Pedagogy And Mathematics Content In Content-Focused Professional Development, Liza Bondurant, Joey Rutherford, Shannon Sharp

Publications

In this Perspective on Practice, we describe how we interpreted, built on, and adapted the design principles shared in “The Content- Focused Methods Course: A Model for Integrating Pedagogy and Mathematics Content” by Steele and Hillen (2012). Using evidence of learning from that report as a foundation, we provide insights into how integrating pedagogy and mathematics content in content-focused professional development (CFPD) influenced our evidence of learning.


Classifying Detrital Zircon U-Pb Age Distributions Using Automated Machine Learning, Jack W. Fekete, Glenn R. Sharman, Xiao Huang Jun 2025

Classifying Detrital Zircon U-Pb Age Distributions Using Automated Machine Learning, Jack W. Fekete, Glenn R. Sharman, Xiao Huang

Geosciences Faculty Publications and Presentations

The prodigious use of detrital zircon U-Pb geochronology for provenance studies in recent decades has led many researchers to amass extensive datasets (>100,000 dates). When displayed as age distributions, individual samples are traditionally compared using visual inspection and statistical methods, which can become timeconsuming and challenging when using large datasets. We propose that machine learning (ML) can more efficiently classify a sample by its source using detrital zircon U-Pb age distributions. Specifically, we hypothesize that automated machine learning (AutoML), which optimizes algorithm selection and hyperparameters, will outperform an unoptimized Random Forest (RF) classifier and the cross-correlation coefficient (R-2), a …


The Games Kids Play: Determining Concussion Risk Of Playground Sports, Brynlee Morgan Jun 2025

The Games Kids Play: Determining Concussion Risk Of Playground Sports, Brynlee Morgan

Health, Human Performance and Recreation Undergraduate Honors Theses

Playground games play a very vital role in child development, but they have been shown to present significant risks of injury, particularly concussion injuries. Supervisors of playground games or recreational sports may lack comprehensive knowledge of concussion protocols, potentially resulting in undiagnosed pediatric concussion, which can be critical to the child’s long-term health. This study aims to identify which playground games or recreational sports pose the highest risk for injury, specifically concussions, and highlights the importance of concussion prevention training for all school personnel to minimize potential health risks for children. The methodology involved the identification of injuries from playground …


Covid-19 And Gender Gap In Labor Market Recovery: Evidence From Nigeria, Marup Hossain Jun 2025

Covid-19 And Gender Gap In Labor Market Recovery: Evidence From Nigeria, Marup Hossain

Economics Faculty Publications and Presentations

The COVID-19 pandemic-driven economic downturn can have substantial implications for the gender gap in the labor market in developing countries, where women are already worse off in job participation and earnings than men. After more than two years of the pandemic, how has the labor market reshaped in developing countries like Nigeria? Using multiple rounds of data before and after the pandemic and incorporating a difference-in-differences design, we show that overall employment dropped in the post-epidemic period in Nigeria. Importantly, overall employment fell more for women than men in Nigeria. Women in the high-COVID-intensity areas also experienced a larger shift …


Contemplative Practices Facilitating Awareness, Compassion, And Healing In Study Abroad: A Reflective And Explorative Study, Ciara C. Hoyne, Jing Lin Jun 2025

Contemplative Practices Facilitating Awareness, Compassion, And Healing In Study Abroad: A Reflective And Explorative Study, Ciara C. Hoyne, Jing Lin

Journal of Contemplative and Holistic Education

This reflective essay focuses on the relationship between contemplative practices and participation in a short-term study abroad trip. The study explores how contemplative practices help facilitate self-understanding, alleviate stress, enhance connection to the host community and culture, and enable healing. We use our experiences participating in a short-term study abroad program as an example for examining the role of contemplative practices in the context of study abroad. We discuss and integrate relevant literature on the topic of meditation, mindfulness, and contemplative inquiry to offer insight into how contemplative practices can be integrated into study abroad in a way that enhances …


The Complex Interplay Between Intellectual Property And The Right To Science, Peter K. Yu Jun 2025

The Complex Interplay Between Intellectual Property And The Right To Science, Peter K. Yu

Faculty Scholarship

In April 2020, the U.N. Committee on Economic, Social and Cultural Rights released General Comment No. 25, which provides an authoritative interpretation of the right to science—a right that has hitherto not received much attention. In light of this publication and the recent celebration of the 75th anniversary of the Universal Declaration of Human Rights, this article examines the complex interplay between intellectual property and the right to science, with a view toward the human rights challenges brought about by both the COVID-19 pandemic and the arrival of generative AI.

The article begins by documenting the historical evolution of the …


The School Counselors Role In Supporting Teachers Working With Children Who Have Experienced Trauma: Lessons Learned, Kristi L. Perryman, T.J. Timothy, Hailey Thomas Frost Jun 2025

The School Counselors Role In Supporting Teachers Working With Children Who Have Experienced Trauma: Lessons Learned, Kristi L. Perryman, T.J. Timothy, Hailey Thomas Frost

Counseling, Leadership, and Research Methods Faculty Publications and Presentations

Teachers are dealing with the challenges of educating students who have been exposed to Adverse Childhood Experiences (ACEs) at an increasing rate (Brunzell et al., 2021; Mayor, 2021). Often their education has not prepared them for recognizing and mitigating the behaviors associated with ACE exposures. This article offers a review of current research regarding the role of the school counselor in supporting teachers. A case study provides insight into this support through a university partnership with a trauma-focused charter school. Suggestions are offered for teacher training and policy changes based on the author's experiences in working with a trauma-focused school. …


The Lived Experiences Of African American Women In Student Affairs Leadership, Beverly David-Lewis Jun 2025

The Lived Experiences Of African American Women In Student Affairs Leadership, Beverly David-Lewis

Education Doctoral

African American women are underrepresented in student affairs administration (Breeden, 2021). Several barriers limit opportunities for career advancement for African American women in this field, including the lack of mentors, minimal decision-making power, and the impact of both sexism and racism (Davis et al., 2021). This qualitative phenomenological research study explored the lived experiences of African American women in student affairs leadership positions at 4-year public institutions in New York State. This study answered the following research questions: 1. What are the perceived barriers that African American women experience when seeking career advancement in student affairs? 2. What strategies have …


Stress Reactivity And Sociocultural Learning: More Stress-Reactive Individuals Are Quicker At Learning Sociocultural Norms From Experiential Feedback, Shilpa Madan, Krishna Savani, Pranjal H. Mehta, Desiree Y. Phua, Ying-Yi Hong, Michael W. Morris Jun 2025

Stress Reactivity And Sociocultural Learning: More Stress-Reactive Individuals Are Quicker At Learning Sociocultural Norms From Experiential Feedback, Shilpa Madan, Krishna Savani, Pranjal H. Mehta, Desiree Y. Phua, Ying-Yi Hong, Michael W. Morris

Research Collection Lee Kong Chian School Of Business

When interacting with others in unfamiliar sociocultural settings, people need to learn the norms guiding appropriate behavior. The present research investigates an individual difference that helps this kind of learning: stress reactivity. Interactions in an unfamiliar sociocultural setting are stressful, particularly when the actor fails to follow its rules. Although stress is typically considered a liability, more stress-reactive individuals may be more motivated to improve, and, thus, quicker to learn these rules. Consistent with this idea, a pilot study found that people genetically inclined to stress reactivity, as computed by a genetic profile score across 59 single nucleotide polymorphisms on …


Major Customers And Carbon Footprints Along The Supply Chain, Saiying Deng, Tinghua Duan, Frank Weikai Li, Xiaoling Pu Jun 2025

Major Customers And Carbon Footprints Along The Supply Chain, Saiying Deng, Tinghua Duan, Frank Weikai Li, Xiaoling Pu

Research Collection Lee Kong Chian School Of Business

This paper examines whether major corporate customers curb corporate carbon emissions along the supply chain. We show that suppliers with a more concentrated customer base have significantly lower carbon emissions. The results are robust to alternative measures of carbon emissions and customer concentration, alternative sample, alternative explanation, and various approaches to mitigate endogeneity concerns. The effect is more pronounced when major customers have made emission-reduction commitment, when they are exposed to greater climate regulatory shocks and risks, and when they become more concerned about regulatory scrutiny. Moreover, the curbing effect of major customers on supplier carbon emissions is stronger when …


Middle Meningeal Artery Embolization As A Perioperative Adjunct To Surgical Evacuation Of Nonacute Subdural Hematomas: An Multicenter Analysis Of Safety And Efficacy, Walid K Salah, Cordell Baker, Jonathan P Scoville, Joshua C Hunsaker, Christopher S Ogilvy, Justin M Moore, Howard A Riina, Elad I Levy, Alejandro M Spiotta, Brian T Jankowitz, C Michael Cawley, Alexander A Khalessi, Omar Tanweer, Ricardo Hanel, Bradley A Gross, Okkes Kuybu, Alex Nguyen Hoang, Ammad A Baig, Mir Hojjat Khorasanizadeh, Aldo A Mendez, Gustavo Cortez, Jason M Davies, Sandra Narayanan, Brian M Howard, Michael J Lang, Adnan H Siddiqui, Ajith Thomas, Peter Kan, Jan-Karl Burkhardt, Mohamed M Salem, Ramesh Grandhi Jun 2025

Middle Meningeal Artery Embolization As A Perioperative Adjunct To Surgical Evacuation Of Nonacute Subdural Hematomas: An Multicenter Analysis Of Safety And Efficacy, Walid K Salah, Cordell Baker, Jonathan P Scoville, Joshua C Hunsaker, Christopher S Ogilvy, Justin M Moore, Howard A Riina, Elad I Levy, Alejandro M Spiotta, Brian T Jankowitz, C Michael Cawley, Alexander A Khalessi, Omar Tanweer, Ricardo Hanel, Bradley A Gross, Okkes Kuybu, Alex Nguyen Hoang, Ammad A Baig, Mir Hojjat Khorasanizadeh, Aldo A Mendez, Gustavo Cortez, Jason M Davies, Sandra Narayanan, Brian M Howard, Michael J Lang, Adnan H Siddiqui, Ajith Thomas, Peter Kan, Jan-Karl Burkhardt, Mohamed M Salem, Ramesh Grandhi

Faculty, Staff and Students Publications

Background

By 2030, nonacute subdural hematomas (NASHs) will likely be the most common cranial neurosurgery pathology. Treatment with surgical evacuation may be necessary, but the recurrence rate after surgery is as high as 30%. Minimally invasive middle meningeal artery embolization (MMAE) during the perioperative period has been posited as an adjunctive treatment to decrease the potential for recurrence after surgical evacuation. We evaluated the safety and efficacy of concurrent MMAE in a multi-institutional cohort.

Methods

Data from 145 patients (median age 73 years) with NASH who underwent surgical evacuation and MMAE in the perioperative period were retrospectively collected from 15 …


Enditnow Impact Study Findings, Shannon M. Trecartin, René Drumm, Petr Cincala, Ellen Nogueira Rodrigues, Yazmik Cantillano, Kayla-Hope Bruno, Lalramliani Ralte Jun 2025

Enditnow Impact Study Findings, Shannon M. Trecartin, René Drumm, Petr Cincala, Ellen Nogueira Rodrigues, Yazmik Cantillano, Kayla-Hope Bruno, Lalramliani Ralte

Faculty Publications

In January 2025, researchers at Andrews University (AU) initiated a study to evaluate Seventh-day Adventist churches’ engagement with the 2024 Abuse Prevention or enditnow Sabbath. The purpose of the study was initially to assess visibility and participation through the publicly available digital platforms of the sampled churches. The findings from that investigation were reported to the Departments of Archives and Statistics and Women’s Ministries in June 2025. The study’s scope expanded when researchers received a faculty research grant from Andrews University’s Office of Research to further investigate how Adventist churches across the NAD participate in the enditnow Sabbath. This report …


Water Quality Assessment: Endotoxin Brings Real-Time Measurements And Non-Faecally Transmitted Bacteria To The Table, Christian Good, João Brandão, Christopher Seymour, Simon K. Jackson Jun 2025

Water Quality Assessment: Endotoxin Brings Real-Time Measurements And Non-Faecally Transmitted Bacteria To The Table, Christian Good, João Brandão, Christopher Seymour, Simon K. Jackson

School of Biomedical Sciences

We have used a rapid, portable assay (Bacterisk) to determine the bacterial water quality along several inland waters in SW England. Water samples were compared by a conventional membrane filter and culture methods for faecal indicator bacteria (FIB; E. coli and enterococci) and endotoxin measurement by Bacterisk. The Bacterisk data, measured in near-real-time, correlate well with both E. coli and enterococci, but also allow the presence of potential pathogens of a non-faecal origin to be detected. The sensitivity was calculated to be 92.96% with a specificity of 46.3% for E. coli with an expanded uncertainty of 22.07% and an Endotoxin …


Microplastics In Urine, Sputum And Lung Lavage Fluid From Patients With Respiratory Illnesses, Faezeh Jahedi, Neamatollah Jaafarzadeh Haghighi Fard, Mehdi Ahmadi, Afshin Takdastan, Maryam Haddadzadeh Shoushtari, Reza Dehbandi, Andrew Turner Jun 2025

Microplastics In Urine, Sputum And Lung Lavage Fluid From Patients With Respiratory Illnesses, Faezeh Jahedi, Neamatollah Jaafarzadeh Haghighi Fard, Mehdi Ahmadi, Afshin Takdastan, Maryam Haddadzadeh Shoushtari, Reza Dehbandi, Andrew Turner

School of Geography, Earth and Environmental Sciences

Because of the ubiquity of microplastics (MPs) in the environment there are concerns regarding human exposure. In this study, MPs have been determined in three physiological fluids: urine, sputum and bronchoalveolar fluid (BALF); from 30 adult patients in Iran with respiratory conditions. A total of nine small (20–100 μm) and mainly green and red fibres of polyethylene, polypropylene and polystyrene construction were detected in urine samples of eight participants. By contrast, 358 MPs that were dominated by small, white and transparent fibres, but also included larger (100–500 μm) fibres and fragments and spherules of various sizes, were detected in sputum …


Conduction System Pacing Compared With Biventricular Pacing For Cardiac Resynchronization Therapy In Patients With Heart Failure And Mildly Reduced Left Ventricular Ejection Fraction: Results From International Collaborative Lbbap Study (I-Clas) Group, Pugazhendhi Vijayaraman, Francesco Zanon, Shunmuga Sundaram Ponnusamy, Bengt Herweg, Parikshit Sharma, Manuel Molina-Lerma, Marek Jastrzębski, Zachary Whinnett, Kevin Vernooy, Rajeev K Pathak, Roderick Tung, Gaurav Upadhyay, Karol Curila, Dipen Zalavadia, Nischay Shah, Lina Marcantoni, Mohamed Gad, Ramez Morcos, Pawel Moskal, Akriti Naraen, Mishal Mumtaz, Jamario R Skeete, Praneet S Katrapati, Jeffrey Kolominsky, Johan Van Koll, Mihail G Chelu, Kenneth A Ellenbogen, Oscar Cano Jun 2025

Conduction System Pacing Compared With Biventricular Pacing For Cardiac Resynchronization Therapy In Patients With Heart Failure And Mildly Reduced Left Ventricular Ejection Fraction: Results From International Collaborative Lbbap Study (I-Clas) Group, Pugazhendhi Vijayaraman, Francesco Zanon, Shunmuga Sundaram Ponnusamy, Bengt Herweg, Parikshit Sharma, Manuel Molina-Lerma, Marek Jastrzębski, Zachary Whinnett, Kevin Vernooy, Rajeev K Pathak, Roderick Tung, Gaurav Upadhyay, Karol Curila, Dipen Zalavadia, Nischay Shah, Lina Marcantoni, Mohamed Gad, Ramez Morcos, Pawel Moskal, Akriti Naraen, Mishal Mumtaz, Jamario R Skeete, Praneet S Katrapati, Jeffrey Kolominsky, Johan Van Koll, Mihail G Chelu, Kenneth A Ellenbogen, Oscar Cano

Faculty, Staff and Students Publications

Background: Cardiac resynchronization therapy (CRT) is a guideline-recommended therapy in patients with heart failure with mildly reduced ejection fraction (HFmrEF, 36%-50%) and left bundle branch block or indication for ventricular pacing. Conduction system pacing (CSP) using left bundle branch area pacing or His bundle pacing has been shown to be a safe and physiologic alternative to biventricular pacing (BVP).

Objective: The aim of this study was to compare the clinical outcomes between BVP and CSP for patients with HFmrEF undergoing CRT.

Methods: Consecutive patients who underwent BVP or CSP with HFmrEF between January 2018 and June 2023 at 16 international …


A Phenotypic Screen Identifies Xanthohumol And Other Flavonoids As Killers Of Bladder Cancer, Michael J Bolt, Jessica Oceguera, Alejandra Rivera Tostado, Christopher D Candler, Elina Mosa, Kazem Safari, Maureen G Mancini, Michael A Mancini Jun 2025

A Phenotypic Screen Identifies Xanthohumol And Other Flavonoids As Killers Of Bladder Cancer, Michael J Bolt, Jessica Oceguera, Alejandra Rivera Tostado, Christopher D Candler, Elina Mosa, Kazem Safari, Maureen G Mancini, Michael A Mancini

Faculty, Staff and Students Publications

Bladder cancer accounts for 4 % of cancer diagnoses in the US. Current treatments primarily involve trans-urethral resection of bladder tumors (TURBT) and immunotherapy with Bacille Calmette-Guerin (BCG). Despite the efficacy of TURBT, issues with residual tumors persist. We chose to utilize Cell Painting to screen a set of 244 flavonoid compounds for bladder cancer cell toxicity. Using multiparametric high content analysis termed SPACe, we discover promising candidates underscoring the potential of flavonoids in targeting bladder cancer cells and elucidating their mechanisms of action. Notably, compounds such as xanthohumol show promise in reducing cancer cell viability by altering lipid metabolism. …


G-Protein Coupled Receptors In Metabolic Reprogramming And Cancer, Songyeon Ahn, Benny Abraham Kaipparettu Jun 2025

G-Protein Coupled Receptors In Metabolic Reprogramming And Cancer, Songyeon Ahn, Benny Abraham Kaipparettu

Faculty, Staff and Students Publications

G-protein coupled receptors (GPCR) are one of the frequently investigated drug targets. GPCRs are involved in many human pathophysiologies that lead to various disease conditions, such as cancer, diabetes, and obesity. GPCR receptor activates multiple signaling pathways depending on the ligand and tissue type. However, this review will be limited to the GPCR-mediated metabolic modulations and the activation of relevant signaling pathways in cancer therapy. Cancer cells often have reprogrammed cell metabolism to support tumor growth and metastatic plasticity. Many aggressive cancer cells maintain a hybrid metabolic status, using both glycolysis and mitochondrial metabolism for better metabolic plasticity. In addition …


Fetal Body Composition In Twins And Singletons, Jessica L Gleason, Wesley Lee, Zhen Chen, Kathryn A Wagner, Dian He, William A Grobman, Roger B Newman, Seth Sherman, Robert Gore-Langton, Edward Chien, Luis Goncalves, Katherine L Grantz Jun 2025

Fetal Body Composition In Twins And Singletons, Jessica L Gleason, Wesley Lee, Zhen Chen, Kathryn A Wagner, Dian He, William A Grobman, Roger B Newman, Seth Sherman, Robert Gore-Langton, Edward Chien, Luis Goncalves, Katherine L Grantz

Faculty, Staff and Students Publications

Importance: An emerging paradigm attributes third-trimester fetal growth deceleration in uncomplicated twin pregnancies to an evolutionary adaptive process. Evaluating longitudinal fetal soft-tissue development may provide important insights into differential fetal growth trajectories between twins and singletons.

Objective: To compare twin vs singleton lean and fat tissue growth across pregnancy.

Design, setting, and participants: Prospective cohort study of dichorionic twins and singletons with serial ultrasound scans to chart fetal growth (2009-2013) and collect fetal volume data to measure fat and lean tissue (2015-2019) in 12 US clinical centers. Participants were individuals with singleton (n = 2802 enrolled) and twin (n = …


The Silicon Shrink: How Artificial Intelligence Made The World An Asylum By Daniel Oberhaus: Reviewed By Hannah Drayson, Hannah Drayson Jun 2025

The Silicon Shrink: How Artificial Intelligence Made The World An Asylum By Daniel Oberhaus: Reviewed By Hannah Drayson, Hannah Drayson

School of Art, Design and Architecture

No abstract provided.