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Articles 177301 - 177330 of 5160260
Full-Text Articles in Entire DC Network
Belonging Against The Odds: Exploring Restorative Justice Practices As Pathways To Foster Belonging In New York City Transfer Schools, Miguel Rodriguez
Belonging Against The Odds: Exploring Restorative Justice Practices As Pathways To Foster Belonging In New York City Transfer Schools, Miguel Rodriguez
Dissertations, Theses, and Capstone Projects
The U.S. education system perpetuates structural inequities that disproportionately affect Black students with the School-to-Prison Pipeline (STPPL) criminalizing them through Zero-Tolerance policies. Transfer schools are often a last resort for students pushed out of traditional schools provide a lens to examine the impact of Restorative Justice Practices (RJP) and Black student representation on belonging. This quantitative dissertation study analyzes secondary data from the NYC Department of Education using multivariate models to explore the relationship between RJPs and sense of belonging (SOB). Model 1 found that discussing feelings and emotions at school (Tier 1 RJP) had the strongest association with SOB …
The Supreme Court’S Old Habits In A New Era? Native Nations, Statehood, And An Indigenous-Led Future For Natural Resources, Monte Mills
Articles
art I of this essay looks back and, relying on Winans and Winters, illustrates the Court’s longstanding commitment to a recognition of tribally reserved rights while requiring a collaborative approach that acknowledges some state interest and authority. Part II then briefly assesses the modern era of Indigenous leadership in natural resources, reviewing the ways in which Native Nations are implementing a new framework of collaborative stewardship for lands, waters, wildlife, and other ecological systems. Finally, Part III considers how the lessons or impacts of this broader movement might be relevant in future conflicts raising questions of statehood and tribal …
Democratic Lawyering: Upending The "Hidden Curriculum" To Prepare New Lawyers For A New World, Eduardo R.C. Capulong, Andrew King-Ries, Monte Mills
Democratic Lawyering: Upending The "Hidden Curriculum" To Prepare New Lawyers For A New World, Eduardo R.C. Capulong, Andrew King-Ries, Monte Mills
Articles
Multiple heightening crises reveal the deficiencies and contradictions of legal education, in particular the values it imparts. Perpetuating myths about U.S. democracy and rule of law, the enduring formalist, liberal legalist cast of law school is increasingly at odds with students’ lived experiences. As liberal democracy and the rule of law falter, no longer is relying on the “hidden curriculum” or the historically nebulous and mythical narratives of the law and our legal system sufficient to prepare tomorrow’s lawyers for the challenges faced by our profession. Instead, with a boost from ABA Standard 303, this article draws on the tradition …
Integrating Social-Emotional Learning And Standards-Based Grading: Principles, Barriers, And Future Directions, Nicole R. Skaar, Matt Townsley
Integrating Social-Emotional Learning And Standards-Based Grading: Principles, Barriers, And Future Directions, Nicole R. Skaar, Matt Townsley
Faculty Publications
Classroom grading reform and students’ whole child development are two important and timely topics in today's schools. In this article, the authors draw parallels between CASEL's five core competencies of social and emotional learning and the guiding principles of standards-based grading (SBG). This article helps educators understand SEL competencies and SBG principles as well as barriers to implementation. The authors outline how explicitly developing students’ social-emotional learning skills and implementing SBG are complementary. Implications for practice and research are discussed. Impact Statement: As schools are tasked with continuous improvement through systemic reform, school personnel can feel overwhelmed by the number …
Lse-Net: Integrated Segmentation And Ensemble Deep Learning For Enhanced Lung Disease Classification, Bhavan Kumar Basavaraju, Mohammad Masum
Lse-Net: Integrated Segmentation And Ensemble Deep Learning For Enhanced Lung Disease Classification, Bhavan Kumar Basavaraju, Mohammad Masum
Faculty Research, Scholarly, and Creative Activity
Accurate classification of lung diseases is vital for timely diagnosis and effective treatment of respiratory conditions such as COPD, pneumonia, asthma, and lung cancer. Traditional diagnostic approaches often suffer from limited consistency and elevated false-positive rates, highlighting the demand for more dependable automated systems. To address this challenge, we introduce LSE-Net, an end-to-end deep learning framework that combines precise lung segmentation using an optimized U-Net++ with robust classification powered by an ensemble of DenseNet121 and ResNet50. Leveraging structured hyperparameter tuning and patient-level evaluation, LSE-Net achieves 92.7% accuracy, 96.7% recall, and an F1-score of 94.0%, along with improved segmentation performance (DSC …
The Ownership Of Mine Tailings, Barry Barton
Infrastructure From Below: Mediasi Dan Politik Pembangunan Infrastruktur Air Di Kota Balikpapan, Muhammad Althaf Nandiati Yusfid
Infrastructure From Below: Mediasi Dan Politik Pembangunan Infrastruktur Air Di Kota Balikpapan, Muhammad Althaf Nandiati Yusfid
Antropologi Indonesia
The city of Balikpapan is experiencing a water crisis. The discrepancy between the city's water supply and Balikpapan's demography put pressure towards the city's capability of supporting its own citizens. This issue is exacerbated by the development of Indonesia's New Capital (IKN) which is located just outside Balikpapan. Therefore, the development of water infrastructure is imperative for the city. Yet, there's no recent visible development of water infrastructure in the city. However, I argue that water infrastructure development actually exists, though in a subtle form. The informal water suppliers that are prevalent in the city is tied with how the …
Male Layer-Type Birds (Lohmann Brown Classic Hybrid) As A Meat Source For Chicken Pâtés, Nikolay Kolev, Desislav Balev, Stefan Dragoev, Teodora Popova, Evgeni Petkov, Krasimir Dimov, Surendranath Suman, Ana Paula Salim, Desislava Vlahova-Vangelova
Male Layer-Type Birds (Lohmann Brown Classic Hybrid) As A Meat Source For Chicken Pâtés, Nikolay Kolev, Desislav Balev, Stefan Dragoev, Teodora Popova, Evgeni Petkov, Krasimir Dimov, Surendranath Suman, Ana Paula Salim, Desislava Vlahova-Vangelova
Animal and Food Sciences Faculty Publications
The valorisation of underutilized male layer-type chickens offers a sustainable and ethically aligned opportunity for the poultry industry. This study evaluated the feasibility of male layer-type chicken meat in the production of chicken pâtés and compared the effects of different meat sources—commercial broiler (CP), and 5 (5wP) and 9-week-old (9wP) male layer-type chickens—on product quality during refrigerated storage using the general linear model with the Tukey–Kramer post-hoc test. Pâtés made from 5wP meat exhibited the most favourable technological properties, including the lowest (p < 0.05) total expressible fluid (TEF), highest (p < 0.05) water retention (TEFWater), and lowest (p < 0.05) fat content (TEFFat) than CP and 9wP indicating superior emulsion stability. The 5wP …
Analyzing Player Difficulty Perception In Platformers Through Procedural Level Generation, Sasank Madineni
Analyzing Player Difficulty Perception In Platformers Through Procedural Level Generation, Sasank Madineni
Master's Theses
Games utilizing Procedural Level Generation (PLG), such as Roguelikes, are becoming increasingly popular in today's gaming sphere. In games employing PLG, levels are generated randomly or pseudo-randomly, and aim to retain player attention through variance in levels between playthroughs. However, when generating levels with variance in structure and design, player enjoyment is often a mixed bag. With low enjoyment, player retention for these games can dwindle. This study explores the efficacy of real-time difficulty adjustment in procedurally generated platformers, as a method for maintaining stable player enjoyment without causing frustration. This thesis focuses on creating a short user experience, MIMEVA, …
Hybrid Computing For Real-Time Model Predictive Control Of A Buck Converter, Grace Paladichuk
Hybrid Computing For Real-Time Model Predictive Control Of A Buck Converter, Grace Paladichuk
Master's Theses
Advancements in power electronics require high switching frequencies which the digital control routines of the systems cannot keep up with. Analog computing is added to digital control systems to prevent bottlenecks and allow real-time implementation. This paper proposes a hybrid computing model predictive control system for a buck converter. The control system implements the gradient dynamics of the optimization function using digital computing, and the gradient dynamics for the penalty function and integrator using analog computing. For the full simulations of the entire system, the PLECS RT Box is used to simulate the controller in real time with a 1 …
Bentonite Erosion And Cation Exchange Effects On Hydraulic Conductivity Of Geosynthetic Clay Liners, Grace Paananen
Bentonite Erosion And Cation Exchange Effects On Hydraulic Conductivity Of Geosynthetic Clay Liners, Grace Paananen
Master's Theses
Geosynthetic clay liners (GCLs) are used in municipal solid waste landfill (MSW) liner and cover systems as an alternative to thick compacted clay layers. Previous field studies have revealed potential for bentonite erosion in GCLs when subjected to wet-dry cycles that occur when GCLs are placed on slopes, covered with a geomembrane, and left exposed without additional soil cover. A laboratory test program was conducted to quantify the effects of bentonite erosion on hydraulic conductivity of sodium-bentonite geosynthetic clay liners and samples subjected to cation exchange treatment in addition to bentonite erosion. This test program determined what level of bentonite …
From Unmotivated To Motivated: Hermeneutic Inquiries Of Experience Of Community-Based Bsw Students In An Innovative Internship Seminar, Hyungjung Shin, Rana Hong, Philip Young P. Hong
From Unmotivated To Motivated: Hermeneutic Inquiries Of Experience Of Community-Based Bsw Students In An Innovative Internship Seminar, Hyungjung Shin, Rana Hong, Philip Young P. Hong
Social Work: School of Social Work Faculty Publications and Other Works
Providing a pathway for disadvantaged community college students in social work education aligns with the goals of diversity, equity, and inclusion in social work education. This hermeneutic phenomenological study aims to explore the experiences of an innovative internship seminar incorporating an evidence-based workforce training model, Transforming Impossible into Possible (TIP), in a community college-based bachelor’s of social work program in South Korea. Of the 59 students who attended the TIP-infused social work internship seminar course in Spring 2018, 11 students participated in repeated in-depth interviews. The results revealed the themes of perception changes in self, others, and the lifeworld and …
International Abolitionist Advocacy: The Rise Of Global Networks To Advance Human Rights And The Promise Of The Worldwide Campaign To Abolish Capital Punishment, John D. Bessler
All Faculty Scholarship
The modern international human rights movement began with the U.N. Charter and the U.N. General Assembly's adoption of the Universal Declaration of Human Rights. Although the movement to abolish the death penalty is rooted in the Enlightenment, global advocacy to halt executions and to abolish capital punishment has accelerated exponentially in recent decades. This Article discusses the origins of global networks to advance human rights and highlights the growing international advocacy, including by nation-states and nongovernmental organizations ("NGOs"), for a worldwide moratorium on executions and to abolish capital punishment altogether. The total number of countries conducting executions in the past …
The Missed Connection: Why Some Travelers Choose Not To Visit Montana, Kika Bradford, Glenna Hartman, Matthew Pettigrew, Melissa Weddell
The Missed Connection: Why Some Travelers Choose Not To Visit Montana, Kika Bradford, Glenna Hartman, Matthew Pettigrew, Melissa Weddell
Institute for Tourism and Recreation Research Publications
Montana attracts millions of visitors drawn by its natural beauty, outdoor recreation, and cultural heritage. A significant portion of these travelers are repeat visitors; however, some travelers visit only once and choose not to return. This study explores what drives that disengagement.
The Road To Montana: Exploring The Decision Paths To Visiting Montana, Kika Bradford, Glenna Hartman, Matthew Pettigrew, Melissa Weddell
The Road To Montana: Exploring The Decision Paths To Visiting Montana, Kika Bradford, Glenna Hartman, Matthew Pettigrew, Melissa Weddell
Institute for Tourism and Recreation Research Publications
Montana’s big skies, outdoor recreation, and cultural heritage attract millions of visitors each year. However, a segment of potential travelers remains unaware and/or disengaged from the state’s tourism market. This study identifies barriers and opportunities in engaging travelers who have never been to Montana.
An Analysis Of Renewable Energy Frames In The News Media Pre- And Post-Trump Administration, Kendall Anjolie Rozen
An Analysis Of Renewable Energy Frames In The News Media Pre- And Post-Trump Administration, Kendall Anjolie Rozen
Communication Studies
This paper aimed to examine how news media portrayed environmental issues, specifically renewable energy, and how this may differ between two presidential administrations in the United States. Entman’s framing theory was used to analyze the portrayals of renewable energy in the articles selected. The frames chosen were based on research done by Rochyadi-Reetz et al. (2019) who established four framing dimensions within environmentally-focused news media. These dimensions are as follows: (1) economy, (2) society, (3) environment, (4) technology. A fifth dimension ((5) policy) was added by the researcher. This paper used a deductive quantitative analysis to mark these themes as …
Analysis Study Of Antibacterial Efficacy And Cytotoxicity Of Prepared Metal-Based Nanoparticles Against Streptococcus Mutans: Focus On Gold Nanoparticles, Fattin Fadhil, Azhar Haleem, Abdulrahman Ali, Ahlam Mohammed
Analysis Study Of Antibacterial Efficacy And Cytotoxicity Of Prepared Metal-Based Nanoparticles Against Streptococcus Mutans: Focus On Gold Nanoparticles, Fattin Fadhil, Azhar Haleem, Abdulrahman Ali, Ahlam Mohammed
Journal of Applied Sciences and Nanotechnology
New approaches have been developed to combat bacterial infections because of the growing threat of antibiotic-resistant bacteria. Gold colloidal nanoparticles and their applications as antibacterial agents have shown promising strategies due to these properties. The properties of nanoparticles, including size, shape, and surface charge, play an essential role in determining antibacterial activity. Pulsed laser ablation in a liquid medium was utilized to produce gold nanoparticles, an environmentally friendly method. Gold NPs were produced in ultrapure water. Experimental research was done to determine the impact of the number of laser pulses on the nanoparticles' size, shape, and concentration. Surface plasmon resonance …
Performance Comparison Of Plasmonic Sensors Via Ion Reduction And Koh Methods, Ruqaya Shlaga, Alwan Alwan, Mohammed Mohammed
Performance Comparison Of Plasmonic Sensors Via Ion Reduction And Koh Methods, Ruqaya Shlaga, Alwan Alwan, Mohammed Mohammed
Journal of Applied Sciences and Nanotechnology
In this work, several types of plasmonic sensors were prepared by different methods (ion reduction method and wet-chemical KOH route) to detect the ultralow anti-CIPRO concentration using AgNPs/PSi SERS-active substrate with AgNPs concentration. The process was optimized to be very effective in detecting CIPRO and to have a high amplification factor (EF). For the deposition of AgNPs with a concentration of 5×10-3 M and the maximum density of hotspot areas, a nanocrystalline silicon sample prepared by the KOH method and an ion reduction technique before etching was used. We tested an AgNPs/PSi SERS substrate, which showed better performance in detecting …
Antibacterial Performance Of Fe₂O₃ Nanoparticles Synthesized Via Biosynthesis From Chitosan, Faisal Kadhim, Mohamed Bedoui, Ali Aldalawi
Antibacterial Performance Of Fe₂O₃ Nanoparticles Synthesized Via Biosynthesis From Chitosan, Faisal Kadhim, Mohamed Bedoui, Ali Aldalawi
Journal of Applied Sciences and Nanotechnology
In this study, Fe₂O₃ nanoparticles were synthesized by a hydrothermal method using chitosan extract and ferric chloride (FeCl₃) as precursor at 150 °C. The hydrothermal approach provides precise control over the size and morphology of the nanoparticles by promoting the decomposition and crystallization of the precursors near their evaporation temperatures. The aim of this study was to quantify the antibacterial activity of the nanoparticles to regulate the production of Fe₂O₃ NPs. The optical and structural properties of Fe₂O₃ nanoparticles (NPs) were investigated and tested using various techniques, including X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), ultraviolet-visible (UV-vis) spectroscopy …
Characterization And Water Uptake Of Reinforced Polymer Blend Using Nanoclay And Rock Wool, Rana Salih, Shanaz Ahmad
Characterization And Water Uptake Of Reinforced Polymer Blend Using Nanoclay And Rock Wool, Rana Salih, Shanaz Ahmad
Journal of Applied Sciences and Nanotechnology
The current work focuses on assessing flexural properties, and water uptake of polymeric composites prepared using various reinforcements. These additives consist of kaolinite nano clays and rock wool (RW). In addition to a polymer blend that consists of epoxy and polyester resins as the matrix. The castings were made using a hand lay-up approach. Nanoclay (NC) was added in weight fractions of 5% and 7%, together with RW added in a volume fraction of 10% as reinforcement. The impact test was employed to decide the optimum mixing ratio of the polymer blend that used as a matrix. From the results …
Unlocking Adolescent And Youth Health - Insights From Adolescent Youth-Friendly Services In Migori County, Kenya: A Cross-Sectional Mixed-Methods Study, Lillian Njoki Nyaga, Eunice Muthoni
Unlocking Adolescent And Youth Health - Insights From Adolescent Youth-Friendly Services In Migori County, Kenya: A Cross-Sectional Mixed-Methods Study, Lillian Njoki Nyaga, Eunice Muthoni
Population Health, East Africa
The provision of adolescent and youth-friendly services (AYFS) can be facilitated by various strategies, including capacity building of health care providers (HCPs), coordination of AYFS, community engagement, and networking of AYFS stakeholders. Adolescents and youth face various health challenges including but not limited to adolescent pregnancies, HIV infections, sexual and gender based violence, strategies that would help curb these challenges is paramount. Although various studies have evaluated AYFS utilization and integration in Kenya, scant data exist on strategies facilitating or hindering the provision of the AYFS in accordance with the Kenya 2016 AYFS guidelines. The aim of this study was …
A Neutrosophic And Q-Rung Orthopair Fuzzy Sets Approach For Desertification Susceptibility Mapping: A Case Study In Matrouh, Egypt, Nabil M. Abdelaziz, Khalid A. Eldrandaly, Amira M. Fawzy, Gehan A. Fouad, Safa Al-Saeed
A Neutrosophic And Q-Rung Orthopair Fuzzy Sets Approach For Desertification Susceptibility Mapping: A Case Study In Matrouh, Egypt, Nabil M. Abdelaziz, Khalid A. Eldrandaly, Amira M. Fawzy, Gehan A. Fouad, Safa Al-Saeed
Neutrosophic Systems with Applications
This study introduces an innovative approach to desertification susceptibility mapping by integrating q-rung orthopair fuzzy sets (Q-ROFS) with a neutrosophic environment. Conducted in Matrouh, Egypt, the research quantifies desertification risk through advanced modeling techniques that address uncertainty and non-linearity in environmental data. The Q-ROFS framework enhances risk prediction by capturing complex relationships among desertification indicators. Neutrosophic logic, meanwhile, effectively addresses imprecision and ambiguity. The resulting susceptibility map clearly distinguishes between vulnerable and non-vulnerable regions, offering valuable guidance for policymakers and planners. The analysis revealed that approximately 79.98% of the study area falls under moderate susceptibility, 14.27% under high susceptibility, and …
A Proposed Mathematical Framework For Fuzzy It Service Management (F-Itsm) And Neutrosophic It Service Management (N-Itsm), Takaaki Fujita
A Proposed Mathematical Framework For Fuzzy It Service Management (F-Itsm) And Neutrosophic It Service Management (N-Itsm), Takaaki Fujita
Neutrosophic Systems with Applications
Fuzzy sets, rough sets, hyperrough sets, intuitionistic fuzzy sets, neutrosophic sets, plithogenic sets , and other frameworks for handling uncertainty are under active research every day. These concepts can model a wide range of real-world phenomena and are frequently investigated to facilitate more efficient decision-making. IT Service Management is a systematic approach to designing, delivering, managing, and improving IT services in alignment with organizational objectives. In this paper, we explore the Mathematical Frameworks for Fuzzy IT Service Management (F-ITSM) and Neutrosophic IT Service Management (N-ITSM), which combine these uncertainty-based ideas with IT Service Management practices.
A Critical Evaluation Of The Criticisms Against Neutrosophic Statistical Methods, Muhammad Aslam, Abdulrahman Alaita, Florentin Smarandache
A Critical Evaluation Of The Criticisms Against Neutrosophic Statistical Methods, Muhammad Aslam, Abdulrahman Alaita, Florentin Smarandache
Neutrosophic Systems with Applications
Neutrosophic statistical analysis has gained attention for incorporating the degree of indeterminacy when analyzing imprecise and interval data under uncertainty–-an aspect often overlooked by classical statistics, fuzzy statistical analysis, and interval statistics. Recently, critical discussions have emerged regarding the use and applications of neutrosophic statistics, with some questioning its usefulness and validity. In this paper, we present a critical assessment of the existing literature, focusing on areas where misunderstandings and misinterpretations of neutrosophic statistical methods have occurred. We also examine flawed comparisons made between the results of neutrosophic statistics and interval statistics. Furthermore, substantial issues have been identified in the …
Dairy & Food Science News, June 2025, Department Of Dairy And Food Science
Dairy & Food Science News, June 2025, Department Of Dairy And Food Science
Dairy & Food Science News
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The Macrophage Sterol Transport Protein Orp2 Promotes Cholesterol Efflux And Prevents Foam Cell Formation And Atherosclerosis, Xiaowei Wang, Kenan Peng, Yudi Zhao, Liwen Qiu, Chenxi Liang, Yaqian Dou, Qianqian Dong, Xiaoting Ma, Jinye Tang, Yidan Ma, Lin Liu, Mingqi Zheng, Hongyuan Yang, Mingming Gao
The Macrophage Sterol Transport Protein Orp2 Promotes Cholesterol Efflux And Prevents Foam Cell Formation And Atherosclerosis, Xiaowei Wang, Kenan Peng, Yudi Zhao, Liwen Qiu, Chenxi Liang, Yaqian Dou, Qianqian Dong, Xiaoting Ma, Jinye Tang, Yidan Ma, Lin Liu, Mingqi Zheng, Hongyuan Yang, Mingming Gao
Faculty, Staff and Student Publications
Cholesterol-loaded macrophage foam cells are a key feature of atherosclerotic plaques. Oxysterol-binding protein-related protein 2 (ORP2) facilitates the transport of cholesterol from lysosomes to the plasma membrane in cultured cell lines. However, the role of ORP2 in macrophages and its involvement in atherosclerosis remain unclear. In this study, we found ORP2 expression was reduced in atherosclerotic vessels and in macrophages exposed to oxidized LDL (ox-LDL). Myeloid-specific human ORP2 overexpression (hORP2MOE) mice were generated and crossed with atherosclerotic-prone ApoE−/− mice and then fed a high-fat diet (HFD) to induce atherosclerosis. Our results showed that myeloid-specific hORP2 overexpression significantly reduced the atherosclerotic …
Endovascular Repair Of Type A Dissection Using Thoracic Stent Graft With Innominate Artery Flaring To Correct For Length Mismatch, Aidin Baghbani-Oskouei, Lucas Ruiter Kanamori, Safa Savadi, Steven Maximus, Thanila A Macedo, Anthony Estrera, Salman A Arain, Gustavo S Oderich
Endovascular Repair Of Type A Dissection Using Thoracic Stent Graft With Innominate Artery Flaring To Correct For Length Mismatch, Aidin Baghbani-Oskouei, Lucas Ruiter Kanamori, Safa Savadi, Steven Maximus, Thanila A Macedo, Anthony Estrera, Salman A Arain, Gustavo S Oderich
Faculty, Staff and Student Publications
Type A aortic dissection is the most common aortic catastrophe posing challenges for endovascular repair owing to the fragile aortic wall, proximity to the aortic valve, coronaries, and supra-aortic trunks. While open surgical repair remains the gold standard, endovascular repair is considered in select high-risk patients who meet anatomical criteria, including more than 10 mm length between sinotubular junction to primary tear, aortic diameter of less than 40 mm, and suitable length between sinotubular junction and innominate artery. This illustrated video and case presentation address a modified technique using stent graft flaring of the innominate artery to adjust for length …
Psychometrics Of Inflammatory Back Pain Criteria In The Us Population, Mark C Hwang, Seokhun Kim, Shervin Assassi, Alexis Ogdie, Michael H Weisman, John Reveille, Charles Green
Psychometrics Of Inflammatory Back Pain Criteria In The Us Population, Mark C Hwang, Seokhun Kim, Shervin Assassi, Alexis Ogdie, Michael H Weisman, John Reveille, Charles Green
Faculty, Staff and Student Publications
Objectives: Evaluation of axial spondyloarthritis relies on capturing various inflammatory back pain (IBP) features represented in different criteria. These criteria are likely to be interpreted differently across demographic subpopulations. We examined IBP criteria dimensionality and differential item functioning (DIF) among different age, gender, and race groups using a nationally representative sample.
Methods: We utilised the National Health and Nutrition Examination Survey (NHANES) 2009-2010 dataset, a US nationally representative data collection with demographic weighting. The Arthritis Questionnaire (ARQ) within NHANES included questions from published Calin, European Spondyloarthropathy Study Group, and Berlin criteria (8a and 7b). Confirmatory factor analysis (CFA) was performed …
Design Of Conquest, A Novel, Randomized, Placebo-Controlled, Phase 2b Platform Clinical Trial To Investigate New Treatments For Patients With Early Active Systemic Sclerosis With Interstitial Lung Disease, Dinesh Khanna, Luke B Evnin, Shervin Assassi, Wade W Benton, Gregory Gordon, Karina Maslova, Juergen Steffgen, Toby M Maher
Design Of Conquest, A Novel, Randomized, Placebo-Controlled, Phase 2b Platform Clinical Trial To Investigate New Treatments For Patients With Early Active Systemic Sclerosis With Interstitial Lung Disease, Dinesh Khanna, Luke B Evnin, Shervin Assassi, Wade W Benton, Gregory Gordon, Karina Maslova, Juergen Steffgen, Toby M Maher
Faculty, Staff and Student Publications
Objective: Safe, effective therapies are urgently needed for patients with systemic sclerosis. However, clinical trial recruitment is challenging given the limited number of people with systemic sclerosis and further restrictions imposed by eligibility criteria. Innovative approaches are needed to accelerate development of new therapies. This article describes the rationale and trial design for CONQUEST (NCT06195072), a novel platform clinical trial sponsored by the Scleroderma Research Foundation, a not-for-profit organization.
Methods: CONQUEST is a multicentre, double-blind, randomized, placebo-controlled, Phase 2b platform trial evaluating the efficacy, safety and pharmacodynamics of multiple investigational products to treat early active systemic sclerosis with …
Perceptions Of The Intensity Of Heart Failure Medications Among Hospitalized Older Adults: A Pilot Qualitative Study, Nuzha A Amjad, Saeed Shoar, Catherine Bryant, Meghan Hunt, Min Ji Kwak
Perceptions Of The Intensity Of Heart Failure Medications Among Hospitalized Older Adults: A Pilot Qualitative Study, Nuzha A Amjad, Saeed Shoar, Catherine Bryant, Meghan Hunt, Min Ji Kwak
Faculty, Staff and Student Publications
Background: Guidelines for heart failure (HF) management recommend high target doses for medications. These targets are based on standardized dosing regimens that rarely consider the complex challenges faced by older patients. However, little is known about such challenges perceived by older adults. We assessed older adults' perceived challenges with HF medication utilization, which may guide a more patient-centered definition of the target intensity for HF medications.
Methods: We conducted a pilot qualitative study using one-on-one, semi-structured interviews with older adults. We included patients over the age of 65 years admitted to the acute cardiac care units (cardiac intensive care unit …