Digital Commons Network^™

Rna Interference In Protozoan Parasites And Its Application, Lon-Fye Lye, Deborah E Dobson, Stephen M Beverley, Min-Che Tung

2020-Current year OA Pubs

RNA interference (RNAi) is a biological process in which RNA molecules are involved in sequence-specific suppression of gene expression, via small RNA triggers derived from double-stranded RNA that can target specific genes; it is a natural process that plays a role in both the regulation of protein synthesis and in immunity. Discovery of RNAi by Fire and Mello in 1998 had a profound impact on unraveling novel aspects of eukaryotic biology. RNA interference (RNAi) has proven to be an immensely useful tool for studying gene function and validation of potential drug targets in almost all organisms. A great advance in …

Evaluating Artificial Intelligence Chatbots For Patient Education In Oral And Maxillofacial Radiology, Dilek Helvacioglu-Yigit, Husniye Demirturk, Kamran Ali, Dania Tamimi, Lisa J. Koenig, Abeer Almashraqi

School of Dentistry Faculty Research and Publications

Objective

This study aimed to compare the quality and readability of the responses generated by 3 publicly available artificial intelligence (AI) chatbots in answering frequently asked questions (FAQs) related to Oral and Maxillofacial Radiology (OMR) to assess their suitability for patient education.

Study Design

Fifteen OMR-related questions were selected from professional patient information websites. These questions were posed to ChatGPT-3.5 by OpenAI, Gemini 1.5 Pro by Google, and Copilot by Microsoft to generate responses. Three board-certified OMR specialists evaluated the responses regarding scientific adequacy, ease of understanding, and overall reader satisfaction. Readability was assessed using the Flesch-Kincaid Grade Level (FKGL) …

Engaging A Community-Academic Partnership To Implement Community-Driven Solutions, Abiola O. Keller, Lindsey St. Arnold Bell, Kristin Haglund

College of Nursing Faculty Research and Publications

Community engagement is a pivotal public health tool for addressing population health challenges and advancing health equity. Community–academic partnerships that use community-engaged approaches can prioritize community strengths and ensure that resources and interventions match local needs. In 2021–2022, a community-academic partnership, guided by the principles of community engagement, collaborated with residents of Milwaukee’s Near West Side (NWS) to identify strengths and assets and prioritize actions to improve health and quality of life. To inform the development of a planned community resource center, residents were invited for group concept mapping (GCM).

Irnet: Immunotherapy Response Prediction Using Pathway Knowledge-Informed Graph Neural Network, Yuexu Jiang, Manish Sridhar Immadia, Duolin Wang, Shuai Zeng, Yen On Chan, Jing Zhou, Dong Xu, Trupti Joshi

Biomedical Sciences

Introduction: Immune checkpoint inhibitors (ICIs) are potent and precise therapies for various cancer types, significantly improving survival rates in patients who respond positively to them. However, only a minority of patients benefit from ICI treatments.

Objectives: Identifying ICI responders before treatment could greatly conserve medical resources, minimize potential drug side effects, and expedite the search for alternative therapies. Our goal is to introduce a novel deep-learning method to predict ICI treatment responses in cancer patients.

Methods: The proposed deep-learning framework leverages graph neural network and biological pathway knowledge. We trained and tested our method using ICI-treated patients’ data from several …

Pediatric Respite Homes: A Call To Action, Amy S. Porter, Jennifer M. Snaman, Jonathan Cottor, Kim Whitmore, Joanne Wolfe

College of Nursing Faculty Research and Publications

Approximately 1 million children with medical complexity (CMC) live in the United States, and although their health care needs comprise 40% of child health costs, most of their care is provided at home by their parents and other family caregivers. Around-the-clock care encompasses direct medical care, including administration of medications and nutrition, care coordination and supplies management, emotional work of vigilance and worry, financial planning, and more. This intensive caregiving offers meaning and joy for many of those parents, yet its constancy can threaten their emotional well-being, physical health, and financial security, presumedly negatively influencing their capacity to provide care …

Do People Judge Sexual Harassment Differently Based On The Type Of Job A Victim Has?, Carolyne Georgiana Halfon, Destiny Mccray, Danica Kulibert

Faculty Articles

Victims of sexual harassment report facing barriers and retaliation for reporting their sexual harassment. The current study assessed one potential reason for these issues: perceptions of sexual harassment events. Participants (N = 427) read about different sexual harassment events and were told that the woman in the event worked with a masculine (e.g., EMT, school police officer, plumber) or feminine job (e.g., nurse, teacher, cleaning staff). Across three different sexual harassment claims (e.g., unwanted romantic attention, physical groping, being shown sexually explicit images), participants reported that women in masculine jobs were less prototypical women than women in feminine jobs. Furthermore, …

Nf2 Loss-Of-Function And Hypoxia Drive Radiation Resistance In Grade 2 Meningiomas, Bhuvic Patel, Sangami Pugazenthi, Shree S Pari, Tatenda Mahlokozera, William A Leidig, Hsiang-Chih Lu, Alicia Yang, Kaleigh Roberts, Patrick Desouza, Kyle P Mcgeehan, Diane D Mao, Namita Sinha, Joseph E Ippolito, Sonika Dahiya, Hiroko Yano, Albert H Kim, Et Al.

2020-Current year OA Pubs

BACKGROUND: World Health Organization Grade 2 meningiomas (G2Ms) often recur and resist therapies. Grade 2 meningiomas with histopathological necrosis have been associated with worse local control (LC) after radiation therapy, but the drivers and biomarkers of radiation resistance in G2Ms remain unknown.

METHODS: We performed genetic sequencing and histopathological analysis of 113 G2Ms and investigated the role of genetic and microenvironmental factors on clonogenic survival after ionizing radiation. We performed transcriptional profiling of our in vitro model and 18 human G2M tumors by bulk RNA sequencing as well as 8 G2Ms by single nuclei RNA sequencing.

RESULTS: NF2 loss-of-function (LOF) …

Age-Related Mesenchymal Stromal Cell Senescence Is Associated With Progression From Mgus To Multiple Myeloma, Natalya Plakhova, Sheila A Stewart, Et Al.

2020-Current year OA Pubs

The risk of progression of monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM) increases with advancing age, suggesting that progression may be influenced by age-related changes within the bone marrow (BM) microenvironment. We hypothesise that senescent mesenchymal stromal cells (MSCs), which accumulate in the BM with age, may contribute to MGUS progression to MM. Here, we show that, like BM MSCs from aged non-cancer controls, BM MSCs from both MM and MGUS patients exhibit a senescent phenotype characterised by enlarged, flattened morphology, increased β-galactosidase activity and CDKN2A expression, and decreased proliferation rate compared with BM MSCs from healthy …

White Matter Microstructure In School-Age Children With Down Syndrome, Dea Garic, Robert C Mckinstry, Natasha Marrus, Kelly N Botteron, Et Al.

2020-Current year OA Pubs

Down syndrome (DS) is the most common genetic cause of intellectual disability, but our understanding of white matter microstructure in children with DS remains limited. Previous studies have reported reductions in white matter integrity, but nearly all studies to date have been conducted in adults or relied solely on diffusion tensor imaging (DTI), which lacks the ability to disentangle underlying properties of white matter organization. This study examined white matter microstructural differences in 7- to 12-year-old children with DS (n = 23), autism (n = 27), and typical development (n = 50) using DTI as well as High Angular Resolution …

Measuring And Interpreting Individual Differences In Fetal, Infant, And Toddler Neurodevelopment, Halie A Olson, M Catalina Camacho, Natasha Marrus, Et Al.

2020-Current year OA Pubs

As scientists interested in fetal, infant, and toddler (FIT) neurodevelopment, our research questions often focus on how individual children differ in their neurodevelopment and the predictive value of those individual differences for long-term neural and behavioral outcomes. Measuring and interpreting individual differences in neurodevelopment can present challenges: Is there a "standard" way for the human brain to develop? How do the semantic, practical, or theoretical constraints that we place on studying "development" influence how we measure and interpret individual differences? While it is important to consider these questions across the lifespan, they are particularly relevant for conducting and interpreting research …

A Systematic Review And Meta-Analysis Of Social Cognition Among People Living With Hiv: Implications For Non-Social Cognition And Social Everyday Functioning, David E Vance, Rebecca Billings, Crystal Chapman Lambert, Pariya L Fazeli, Burel R Goodin, Mirjam-Colette Kempf, Leah H Rubin, Bulent Turan, Jenni Wise, Gerhard Hellemann, Junghee Lee

2020-Current year OA Pubs

Social cognition-the complex mental ability to perceive social stimuli and negotiate the social environment-has emerged as an important cognitive ability needed for social functioning, everyday functioning, and quality of life. Deficits in social cognition have been well documented in those with severe mental illness including schizophrenia and depression, those along the autism spectrum, and those with other brain disorders where such deficits profoundly impact everyday life. Moreover, subtle deficits in social cognition have been observed in other clinical populations, especially those that may have compromised non-social cognition (i.e., fluid intelligence such as memory). Among people living with HIV (PLHIV), 44% …

Phase 2 Open-Label Study Of Sacituzumab Govitecan As Second-Line Therapy In Patients With Extensive-Stage Sclc: Results From Tropics-03, Afshin Dowlati, Anne C Chiang, Andrés Cervantes, Sunil Babu, Erika Hamilton, Shu Fen Wong, Andrea Tazbirkova, Ivana Gabriela Sullivan, Cédric Van Marcke, Antoine Italiano, Jilpa Patel, Sabeen Mekan, Tia Wu, Saiama N Waqar

2020-Current year OA Pubs

INTRODUCTION: The phase 2 TROPiCS-03 study evaluated the efficacy/safety of sacituzumab govitecan (SG) as second-line treatment in patients with previously treated extensive-stage SCLC (ES-SCLC).

METHODS: TROPiCS-03 (NCT03964727) is a multicohort, open-label, phase 2 basket study of solid tumors, including ES-SCLC. Adults with ES-SCLC that progressed after one previous line of platinum-based chemotherapy and anti-programmed death-(ligand) 1 (PD-[L]1) therapy received SG 10 mg/kg on days 1 and 8 of a 21-day cycle. The primary end point was the investigator-assessed objective response rate (ORR) according to Response Evaluation Criteria in Solid Tumors version 1.1. Key secondary end points included investigator-assessed duration of …

Plasma Mtbr-Tau243 Biomarker Identifies Tau Tangle Pathology In Alzheimer's Disease, Kanta Horie, Rama K Koppisetti, Nicolas R Barthélemy, Yingxin He, Chihiro Sato, Brian A Gordon, Hong Jiang, Tammie L S Benzinger, David M Holtzman, John C Morris, Suzanne E Schindler, Randall J Bateman, Et Al.

2020-Current year OA Pubs

Insoluble tau aggregates within neurofibrillary tangles are a defining neuropathological feature of Alzheimer's disease (AD) and closely correlate with clinical symptoms. Although tau pathology can be assessed using tau positron emission tomography, a more accessible biomarker is needed for diagnosis, prognosis and tracking treatment effects. Here we present a new plasma tau species, the endogenously cleaved, microtubule-binding region containing residue 243 (eMTBR-tau243), which specifically reflects tau tangle pathology. Across the AD spectrum in three different cohorts (n = 108, 55 and 739), plasma eMTBR-tau243 levels were significantly elevated at the mild cognitive impairment stage and increased further in dementia. Plasma …

Oh Say Can You Oclc? Locating And Disseminating Government Information In A Post Marcive World, Michelle E. Colquitt

Publications

No abstract provided.

Tacrolimus Ipv Group Membership Does Not Consistently Track With Electronically Monitored Or Self-Reported Adherence In Adolescent And Young Adult Kidney Transplant Recipients, Cyd K. Eaton, Cozumel S. Pruette, Kristin A. Riekert, Nazanin Yousefzadeh, Ahna L. Pai, Sandra Amaral, Vikas R. Dharnidharka, Bärbel Knäuper, Jodi M. Smith, Susan L. Furth, Bethany J. Foster

2020-Current year OA Pubs

BACKGROUND: High intrapatient variability (IPV) of tacrolimus trough concentrations (SD ≥ 2, coefficient of variation (CV%) ≥ 30) is associated with rejection and graft loss and may indicate nonadherence. However, the association between tacrolimus IPV and electronically monitored or self-reported adherence is unknown.

METHODS: This secondary analysis of the TAKE-IT (Teen Adherence in Kidney Transplant Effectiveness of Intervention Trial) compared electronically monitored and self-reported adherence between participants with high and low tacrolimus IPV among 103 adolescent and young adult kidney transplant recipients (mean age = 15.18 y, 59% male, 60% White, 65% >1-y posttransplant).

RESULTS: Electronically monitored daily taking and …

A Subset Of Cortical Areas Exhibit Adult-Like Functional Network Patterns In Early Childhood, Jiaxin Cindy Tu, Xintian Wang, Donna Dierker, Chloe M. Sobolewski, Evan M Gordon, Timothy O Laumann, Adam T Eggebrecht, Muriah D. Wheelock, Et Al.

2020-Current year OA Pubs

The human cerebral cortex contains groups of areas that support sensory, motor, cognitive, and affective functions, often categorized into functional networks. These networks show stronger internal and weaker external functional connectivity (FC), with FC profiles more similar within the same network. Previous studies have shown these networks develop from nascent forms before birth to their mature, adult-like structures in childhood. However, these analyses often rely on adult functional network definitions. This study assesses the potential misidentification of infant functional networks when using adult models and explores the consequences and possible solutions to this problem. Our findings suggest that although adult …

Arkansas Corn And Grain Sorghum Research Studies 2024, Jason Kelley, Travis Faske

Arkansas Agricultural Experiment Station Research Series

The 2024 edition of the Arkansas Corn and Grain Sorghum Research Studies Series includes research results on topics pertaining to corn and grain sorghum production, including weed, disease, nematode, and insect management; economics; irrigation; agronomics; soil fertility; drone use; and research verification program results.

Our objective is to capture and broadly distribute the results of research projects funded by the Arkansas Corn and Grain Sorghum Board. The intended audience includes producers and their advisors, current investigators, and future researchers. The Series serves as a citable archive of research results.

The reports inform and guide our long-term recommendations, but should not …

Issue 1 - Arete Newsletter - 2025, Liberty University

Arete Newsletter

Summer 2025

Developing Machine Learning Models And Graphene-Based Flexible Humidity And Temperature Sensors For Machine-Learning-Assisted Sensing, Seth Hajian

Dissertations

Flexible sensor technology has recently gained tremendous momentum in both academic research and industrial applications, transitioning from conceptual frameworks to practical implementations across diverse fields. This remarkable advancement can be attributed to several converging factors, including the maturation of nanomaterial science, the advancements of machine learning algorithms, and the critical demand for intelligent sensing solutions in healthcare, environmental monitoring, and industrial automation. The growing emphasis on personalized medicine and real-time health monitoring, accelerated by global health challenges, has further highlighted the necessity for accurate, cost-effective, and adaptable sensing platforms. This dissertation presents the fulfillment of three interconnected research projects focused …

A Parallel Fuzzy Logic Framework For Surgical Skill Evaluation Via Instance Segmentation And Deepsort Tracking, Mohsen M. Mohaidat

Dissertations

Manual evaluation of suturing skills during laparoscopic training is often subjective and labor-intensive, resulting in the lack of scalable and consistent feedback for trainees. This study proposes an automated framework that not only significantly reduces the need for in-person assessment by experts but also ensures scalability, thereby addressing the objectivity and cost-effectiveness limitations. While low-cost laparoscopic box trainers have become increasingly popular for residency training, performance assessment still depends on expert supervision. The proposed system aims to alleviate these limitations.

This study introduces a novel automated framework incorporating an optimized DeepSORT algorithm for classifying, localizing, and tracking surgical tools using …

Diagnosis By Algorithm: The Transformative Impact Of Social Media–Driven Adhd Self-Diagnosis For Women Over 30 And The Proposal Of Neurotype Strain Theory, Rebecca Lynn Sevin

Dissertations

This dissertation explores the phenomenon of adult women who self-diagnosed Attention Deficit Hyperactivity Disorder (ADHD) through content encountered on social media platforms. Drawing on interpretive phenomenological analysis of ten in-depth interviews, the study investigates the emotional, cognitive, and institutional dimensions of this self-diagnosis process. Participants, all over the age of 30, reported that social media played a transformative role in helping them recognize ADHD traits in themselves. Rather than being misinformed or seeking shortcuts, participants engaged thoughtfully with ADHD-related content, valuing lived experience itself as a meaningful source of recognition and reflection. Their engagement was not primarily with educational materials …

Pension Participation Among Different Migrant Groups In China: Job Type, Regional Disparities, And Cross-Provincial Mobility, Boxia Xu

Dissertations

As China undergoes rapid economic transformation and urbanization, the migrant population has grown significantly. Although migrants play essential roles in the labor market, they face persistent structural barriers to pension access. Regional disparities, occupational segmentation, and cross-provincial mobility constraints affect the probability of their pension participation. While policy efforts aim to expand coverage, the fragmented nature of China’s pension system continues to hinder equitable access for migrants. As a result, ensuring pension participation among migrant groups remains a pressing challenge.

Using data from the 2014 China Migrants Dynamic Survey (CMDS), this dissertation employs logistic regression models to investigate how job …

A Comparative Case Study On Special Education Administrator’S Education And Experience: Perceptions Of The Effectiveness Of The Support Provided To Probationary Special Education Teachers, Diane Smith Glover

Educational Leadership & Workforce Development Theses & Dissertations

The purpose of this research study was to explore the education and experience of special education administrators (SEAs) and their perceptions of the effectiveness of the support they provide to probationary special education teachers (SETs), particularly in relation to the teachers' professional growth and job satisfaction. This qualitative study employed an interpretive approach, focusing on the perspectives of SEAs regarding their knowledge in special education, the workplace supports they provide, and the impact of these supports on SETs' professional development and career decisions. Data was collected from interviews with 11 SEAs who had experience supervising probationary SETs.

The findings revealed …

Statewide Universal School Meal Policies And Food Insecurity In Households With Children, Dania Orta-Aleman, Marlene B. Schwartz, Anisha I. Patel, Michele Polacsek, Christina A. Hecht, Kenneth Hecht, Monica D. Zuercher, Lorrene D. Ritchie, Juliana F W Cohen, Wendi Gosliner

Health Sciences Faculty Publications

No abstract provided.

Pharmacy Matters June 2025, University Of Mississippi School Of Pharmacy

Pharmacy Matters Newsletters

Featured stories: Capping off Success: Celebrating the Classes of 2025, Barber Reaches 'Pinnacle of Teaching' with TEACH Prize Win, Pharmacy Professor Works to Unlock Secrets of Cellular Sugar, Staff Excellence Celebrated During Appreciation Week, Professor Awarded for Community Project Focused on Health in the Delta, Graduate Student Earns University Service Award, Repka, Roman Receive Prestigious UM Awards, Wilsons Continue Legacy of Giving with Sports Pharmacy Funding

Supreme Court Lgbtq Orthodoxy, Carlos A. Ball

Missouri Law Review

This Article argues that the Supreme Court has relied on two simplifying assumptions in First Amendment exemption cases involving LGBTQ issues. The first assumption is that the government’s interest in addressing and remedying discrimination is irrelevant to the matter at hand. The second assumption is that state officials, in enforcing sexual orientation antidiscrimination laws against individuals who object to them on religious or moral grounds, seek to force the dissenters to speak in ways they do not want to speak. As the Article explains, the Court has abided by neither simplifying assumption in exemption cases involving the application of race …

Flexible Pathways In Medical Science - Evaluating The Impact Of Hyflex Teaching Modes, Aine Balfe

Case studies: Digital Education

The HyFlex teaching model has been implemented in the part-time TU088 Higher Diploma in Medical Science programme to support students who work as hospital laboratory aides. This flexible approach reduces on-site attendance requirements while maintaining academic standards. TU088 runs concurrently with two full-time programs - TU867 BSc in Medical Science and TU888 HDip in Medical Science—and shares key modules delivered in HyFlex mode in stage 2 and stage 4. Additionally, HyFlex is employed in a final-year research module co-taught across TU867, TU866 BSc in Biomedical and Molecular Diagnostics, and TU886 BSc in Biomolecular Science. This supports students completing research projects …

Research Ethics And Integrity, Steve Meaney

Case studies: Digital Education

Research integrity (RI) training is a requirement for all active researchers and research students. At present there are two distinct cohorts – postgraduate student who complete it as part of their induction week at one of three different sessions per year and researchers, who complete the training as part of the Researcher Career Development Framework on a more ad hoc basis. The initial kick-off session is followed by a series of self-directed online activities via a nationally agreed interactive learning platform (Epigeum). For the RCDF in particular, attendance has been a challenge as this cohort includes academic staff with teaching …

Research Ethics - Architect Edition, Steve Meaney

Case studies: Digital Education

As part of the taught postgraduate programmes delivered by the discipline of architecture, there is a requirement for a research project to be carried out. As the majority of students are in practice, such projects are typically practice focused and have unusual research designs. To support good practice in ethics and to accommodate students with diverse professional commitments, I have been involved in delivering a HyFlex session for the last few years in the hardwired design studio space within the School of Architecture, Building and Environment. It was only in the context of the current CoP that this session represented …

Whose Bot Is It Anyway? Determining Liability For Ai-Generated Content, John G. Browning

Northern Illinois University Law Review

As Chief Justice John Roberts noted in his State of the Judiciary address in late December 2023, artificial intelligence has not only had a seismic effect on society and the legal profession, but it is also presenting courts with novel questions to resolve. To date, most of the legal scholarship discussing generative AI has focused on areas like the ethical dimensions of its use, copyright infringement implications, AI governance issues, and the evidentiary questions raised by the use of this technology. However, a void in the scholarship exists with respect to the question of who should be liable for AI-generated …