Digital Commons Network^™

Alternatively Certified Early Childhood Special Education Teachers' Perspectives On Remaining In The Classroom, Sena Victoria Ann Belgard Dever

Walden Dissertations and Doctoral Studies

Alternative teacher certification programs are used nationwide to address the critical teacher shortage in special education. There is a gap in knowledge regarding the challenges that early childhood special education teachers experience, which make them leave the profession at twice the rate of general education teachers. The purpose of this basic qualitative study was to explore alternatively certified early childhood special education teachers’ perspectives on remaining in their teaching positions and the support they need to continue teaching. The study framework was comprised of Day and Gu’s teacher resilience theory. Data were collected from semistructured interviews with 10 prekindergarten to …

Teacher Perceptions On The Low Enrollment Of Students Of Color In High School Computer Science, Wiley J. Cruse, Jr.

Walden Dissertations and Doctoral Studies

The rapid evolution of computer science (CS) as an integral part of K-12 public education in the United States has highlighted significant equity and diversity issues. Guided by critical race theory and community cultural wealth, this basic qualitative study explored high school CS teachers’ perceptions of the challenges and opportunities related to recruiting, retaining, and ensuring the success of students of color. Thematic analysis of data collected using semistructured interviews with 12 high school CS teachers revealed key challenges, including curriculum rigidity, funding inequities, and lack of administrative support. Participants reported that systemic barriers limit access to CS education for …

Staff Education To Improve Nurses’ Knowledge On Medication Administration Error Prevention, Francoise Tabe

Walden Dissertations and Doctoral Studies

This staff education project aimed to enhance nurses’ knowledge on medication administration error prevention through targeted education interventions. Medication administration errors are a significant concern in health care, leading to patient harm and reduced quality of care. This project addressed the gap in nursing knowledge regarding strategies to prevent these errors, with the goal of improving patient safety and outcomes. The practice-focused question explored in this project was the following: How does implementing an education program affect nurses’ knowledge and practices related to medication error prevention? The purpose of this doctoral project was to educate nurses on best practices for …

Intouch Week Of June 2, 2025, New York Medical College

InTouch

• NYMC Celebrates the Class of 2025 at 166th Commencement
• SOM Awards Ceremony Honors Excellence
• SHSP Dean’s Awards Recognize Rising Health Leaders
• GSBMS Honors Excellence in Biomedical Science at Annual Awards Ceremony
• TCDM Celebrates the Class of 2025
• Noninvasive Method for Early Intraventricular Hemorrhage Detection in Preemies Revealed

Und Leads Implementation Team Meeting Agenda — June 2, 2025, University Of North Dakota

LEADS Implementation Documents

Agenda for the June 2, 2025 meeting of the UND LEADS Implementation Team. The agenda welcomes new members and includes subgroup reports, discussion of the Learning data summary, and implications for data-informed recommendations.

Cytarabine Pharmacogenomics And Outcomes Among Children And Young Adults With Acute Myeloid Leukemia., Richard J. Marrero, Vivek M. Shastri, Deedra Nicolet, Krzysztof Mrózek, Christopher J. Walker, William G. Blum, Bayard L. Powell, Jonathan E. Kolitz, Joseph O. Moore, Geoffrey L. Uy, Wendy Stock, Andrew J. Carroll, John C. Byrd, Richard Aplenc, Todd M. Cooper, Alan S. Gamis, Huiyun Wu, Stanley Pounds, Yi-Cheng Wang, Todd A. Alonzo, Soheil Meshinchi, Ann-Kathrin Eisfeld, Edward A. Kolb, Jatinder K. Lamba

Manuscripts, Articles, Book Chapters and Other Papers

IMPORTANCE: Therapeutic responses in acute myeloid leukemia (AML) demonstrate considerable variability both across and within established risk stratifications and age groups. Moreover, significant racial disparities persist, with Black patients experiencing inferior survival outcomes compared with their White counterparts.

OBJECTIVE: To validate the association of the previously reported 10 single nucleotide variant (SNV)-based ara-C pharmacogenomics score (ACS10) with survival outcomes in a large cohort of pediatric AML patients; to evaluate whether ACS10 remains relevant in an adolescent and young adult (AYA) population of patients with AML treated with similar intensive induction chemotherapy protocols; and to assess the association of ACS10 with …

Gomez V. Gomez

All Decisions

The court denied the tenant's motion for a stay and undertaking pending an interlocutory appeal of an order denying dismissal of a holdover petition. The court clarified that CPLR 5519(a)(6) automatic stays only apply to judgments or orders requiring enforcement, such as an eviction. Since the appealed order merely denied dismissal and transferred the case to trial, not directing any specific enforcement action against the tenant, an automatic stay was not warranted.

Irason Llc V. Rivadeneira

All Decisions

Handwritten opinion. In this non-payment proceeding, the court found the landlord's rent demand to be fatally defective. The defect stemmed from the demand requesting an amount $40 over the actual lease and registered rent. This overstatement rendered the demand invalid, leading to the court's decision in favor of the tenant.

Hudson Shore Associates Limited Partnership, Haven On The Hudson Llc, Kenneth Levinson, And Hudson Valley Property Owners Association Et Al. V. State Of New York, New York State Division Of Housing And Community Renewal, Village Of Nyack, New York, And City Of Poughkeepsie, New York

All Decisions

Landlords challenged New York's Vacancy Provisions, alleging Fourth Amendment violations for warrantless searches of rent rolls and Fourteenth Amendment due process violations concerning vacancy calculations. The court affirmed dismissal, holding that Article 78 proceedings provide sufficient pre-compliance review for record demands, and the low risk of coercion mitigates Fourth Amendment concerns. Due process was satisfied by opportunities for landlords to contest vacancy calculations through public hearings and subsequent Article 78 review, ensuring constitutional muster.

Suppression Of Brca1 Facilitates Kidney Regeneration, Kaira A Church, Xunian Zhou, Raghu Kalluri

Faculty, Staff and Student Publications

Maladaptive repair following kidney injury leads to the development of kidney disease. In this issue of JEM, Ajay et al. (https://doi.org/10.1084/jem.20231107) uncover the role of breast cancer susceptibility gene 1 (BRCA1) in cell cycle arrest, DNA damage, and cell senescence, preventing maladaptive repair.

"Opting Out Of Ai”: Exploring Perceptions, Reasons, And Concerns Behind Faculty Resistance To Generative Ai, Aya Shata

Hank Greenspun School of Journalism and Media Studies Faculty Research

Research on Generative Artificial Intelligence (GAI) in higher education primarily focuses on faculty use and experiences, with limited attention given to why some abstain from using it. Drawing from Innovation Resistance Theory, this study aims to address this gap by exploring the perceptions of both faculty users and non-users of GAI, identifying the reasons and concerns why they avoid GAI. A survey of 294 full-time higher education faculty from two mid-size U.S. public universities was conducted. Using qualitative and quantitative analysis, results show that over one-third of the faculty members opted out of using GAI for five primary reasons: not …

Drosha: A New Tumor Suppressor In Pineoblastoma, Zhixuan Huang, Xueli Ren, Jian Hu

Faculty, Staff and Student Publications

In this Outlook, Huang et al. discuss a study in this issue of Genes & Development by Fraire et al. that shows that a deficiency in miRNA processors Drosha and Dicer and consequent cell cycle gene derepression promote pineoblastoma development. The authors highlight the heterogeneity of pineoblastoma's pathogenic mechanisms and its implications for therapeutic interventions in the clinic.

Switching On The Evolutionary Potential Of Pancreatic Cancer: The Tumor Suppressor Functions Of Pbrm1, Luigi Perelli, Giannicola Genovese

Faculty, Staff and Student Publications

Cell plasticity is a hallmark of cancer, enabling tumor cells to acquire multiple phenotypes responsible for tumor progression, metastasis, and therapy resistance. In this issue of the JCI, Kawai and colleagues leveraged genetically engineered mouse models (GEMM) of pancreatic ductal adenocarcinoma (PDAC) to demonstrate that loss of Pbrm1, a member of the SWI/SNF complex, drives dedifferentiation and aggressive tumor features. Pbrm1 loss activated a program of epithelial-to-mesenchymal transition (EMT) and allowed the emergence of poorly differentiated histologies that are commonly associated with high recurrence rate and dismal prognosis. These findings reveal the role of the SWI/SNF complex during PDAC evolution …

Hyaluronan Network Remodeling By Zeb1 And Itih2 Enhances The Motility And Invasiveness Of Cancer Cells, Sieun Lee, Jihye Park, Seongran Cho, Eun Ju Kim, Seonyeong Oh, Younseo Lee, Sungsoo Park, Keunsoo Kang, Dong Hoon Shin, Song Yi Ko, Jonathan M Kurie, Young-Ho Ahn

Faculty, Staff and Student Publications

Hyaluronan (HA) in the extracellular matrix promotes epithelial-mesenchymal transition (EMT) and metastasis; however, the mechanism by which the HA network constructed by cancer cells regulates cancer progression and metastasis in the tumor microenvironment (TME) remains largely unknown. In this study, inter-α-trypsin inhibitor heavy chain 2 (ITIH2), an HA-binding protein, was confirmed to be secreted from mesenchymal-like lung cancer cells when cocultured with cancer-associated fibroblasts. ITIH2 expression is transcriptionally upregulated by the EMT-inducing transcription factor ZEB1, along with HA synthase 2 (HAS2), which positively correlates with ZEB1 expression. Depletion of ITIH2 and HAS2 reduced HA matrix formation and the migration and …

A Comprehensive, Multi-Center, Immunogenomic Analysis Of Melanoma Brain Metastases, Lucy Boyce Kennedy, Amanda E D Van Swearingen, Marissa R Lee, Layne W Rogers, Alexander B Sibley, Jeff Sheng, Dadong Zhang, Xiaodi Qin, Eric S Lipp, Swaminathan Kumar, Aron Joon, Pixu Shi, Michael A Davies, Kouros Owzar, Carey K Anders, April K S Salama

Faculty, Staff and Student Publications

Background: Melanoma brain metastases (MBM) have a unique molecular profile compared to extracranial metastases (ECM). Description of the biological features and clinical outcomes of MBM will facilitate the design of rational therapies.

Methods: We examined the mutational landscape and gene expression profiles of MBM (74 patients) and ECM (34 patients) in paired patient samples from a previously published dataset with whole-exome sequencing (WES) and RNA sequencing (RNAseq) data from MD Anderson Cancer Center (MDACC). We also present findings from MBM from a new cohort of 14 patients from Duke University to strengthen investigation of somatic mutations and gene expression profiles. …

Harnessing Electrophiles In Vivo: A Pilot Study In Swine Using A Hydrophobic Radiopaque Formulation Of 2-Propylpentanoyl Chloride, Erik Cressman, Danielle Stolley, Natalie Fowlkes, Edd Felix, Waldemar Priebe, Steve Parrish, David Fuentes

Faculty, Staff and Student Publications

Manipulating biology through chemistry is older than the discipline of chemistry itself. Traditionally, selectivity of oral or intravenous drugs relied on preferential drug-receptor binding. A novel approach exploiting image-guided techniques to impart spatial selectivity opens up a wide range of new possibilities for study and manipulation of biology. Motivated initially by the poor prognosis for solid tumors such as liver cancer, we demonstrate the use of an extreme form of in vivo chemistry for targeted delivery of 2-propylpentanoyl chloride in a swine model. The ensuing reaction in tissue devitalizes it by multiple mechanisms with lasting effects and, critically, demonstrates very …

Climatologist Mann's Defamation Suit Victory: Can It Resolve The Crisis Of Expertise, David S. Caudill

Faculty Publications

When a jury awarded one million dollars in punitive damages to climatologist Michael Mann, in his defamation suit against writer Mark Steyn (who accused Mann of scientific fraud), it was newsworthy, even surprising, because opinions regarding scientific matters are rarely actionable. And yet it was not seen as a groundbreaking event in terms of legal doctrine, since the outcome was easily justifiable— Steyn’s accusation was provably false. However, even if the Constitutional contours of defamation law did not change, the Mann verdict has far-reaching implications for a major contemporary social phenomenon, namely the so-called crisis of expertise, a term identifying …

Phenotypes Of Atopic Dermatitis And Development Of Allergic Diseases, Alexandra R Sitarik, Katherine Rivera-Spoljaric, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Atopic dermatitis (AD) is the most common inflammatory disease in childhood, and children with AD are more likely to develop other allergic diseases, including food allergy, allergic rhinitis, and asthma.

OBJECTIVE: To determine the phenotypes of AD expression across 12 US birth cohorts and identify factors associated with phenotype and development of allergic diseases.

DESIGN, SETTING, AND PARTICIPANTS: This cohort study compiled longitudinal data from 12 observational US birth cohorts across decades (children born from April 1980 to June 2019) in the Environmental Influences on Child Health Outcomes (ECHO) Children's Respiratory and Environmental Workgroup with follow-up to September 2022. …

Mooc For Sustainability: Cultivating Sustainability Leadership In Campus Management Through Open Online Education, Pilvi Posio, Emmanuel D. Delocado

Journal of Management for Global Sustainability

Higher education institutions (HEIs) serve as key hubs of education and research while also acting as influential societal agents in advancing sustainability. As HEIs increasingly integrate sustainability into their education, research, and operations, their role as sustainability leaders continues to evolve. This article explores how HEIs can cultivate sustainability leadership and institutional agency through open, digital education formats within the integrative framework of campus sustainability. Drawing from a case study on the development of the MOOC for Sustainability: Empowering Global Campuses course coordinated by the Finnish University Network for Asian Studies (Asianet), it examines how sustainability leadership education can be …

What Are “Wartime Authorities” And When Can The President Use Them? An Expert Q&A, Tess Bridgeman, Rebecca Ingber, Scott Roehm

Online Publications

The first several months of President Donald Trump’s second administration have been marred by the chaotic and often unlawful use, or threatened use, of wartime and terrorism-related authorities for what are essentially domestic immigration or criminal law enforcement purposes. This is not the first time a president has sought to push the boundaries of his wartime powers, or outright claimed those he did not have, but it may well be the most extreme. Indeed, Trump’s reliance on wartime authorities in contexts entirely divorced from armed conflict, or even the threat of force against the United States, puts the country on …

Adapting The Comprehensive Assessment Of Acceptance And Commitment Therapy Processes (Compact) Questionnaire For Contextual Relevance In Uganda: A Comprehensive Approach, Joseph Mugarura, Khamisi Musanje, Michael E. Levin, Ronald Asiimwe, Morris Ndeezi, Simon Kizito, Ross G. White, Rosco Kasujja

Psychology Faculty Publications

The global utility of acceptance and commitment therapy highlights the need for adapting measures that can effectively capture the richness of psychological flexibility. One such instrument is the Comprehensive Assessment of Acceptance and Commitment Therapy Processes (CompACT). We translated the CompACT into Luganda and adapted it for use in Uganda. The original CompACT was translated into the Luganda language and reviewed through a series of evaluations. Nine mental health professionals participated in one-on-one interviews, while a focus group of eight culturally competent laypersons provided further insights. Their feedback resulted in revisions to enhance the instrument’s clarity, relevance, acceptability and completeness. …

Judgment Bias, Fear, And Stress Responses Of Red Junglefowl And Athens Canadian Random Bred Chickens, Victor J. Oyeniran, Rosemary H. Whittle, Sara K. Orlowski, Shawna L. Weimer

Poultry Science Faculty Publications and Presentations

Understanding how poultry perceive and interpret their environment is essential to enhancing their welfare. Animal welfare science relies on measures of the behavioral and physiological components of affective states (positive and negative) as welfare indicators. There has been growing interest in using the judgment bias test (JBT) to study birds' affective states by assessing their responses to ambiguous cues. The objective of this study was to investigate the affective state of two chicken breeds with different evolutionary histories: the Red Junglefowl (RJF), the primary ancestor of modern chickens, and the Athens Canadian Random Bred (ACRB), a rustic domesticated breed, using …

Ocular Phenotyping Of Knockout Mice Identifies Genes Associated With Late Adult Retinal Phenotypes, Abraham Hang, Andy Shao, Michael Shea, Michel J Roux, Denise M Imai-Leonard, David J Adams, Takanori Amano, Oana V Amarie, Zorana Berberovic, Raphaël Bour, Lynette Bower, Brian C Leonard, Steve D Brown, Soo Young Cho, Sharon Clementson-Mobbs, Abigail J D'Souza, Mary Dickinson, Mohammad Eskandarian, Ann M Flenniken, Helmut Fuchs, Valerie Gailus-Durner, Jason Heaney, Yann Hérault, Martin Hrabe De Angelis, Chih-Wei Hsu, Shundan Jin, Russell Joynson, Yeon Kyung Kang, Haerim Kim, Hiroshi Masuya, Ki-Hoan Nam, Hyuna Noh, Lauryl M J Nutter, Marcela Palkova, Jan Prochazka, Miles Joseph Raishbrook, Fabrice Riet, Jason Salazar, John Richard Seavitt, Radislav Sedlacek, Mohammed Selloum, Kyoung Yul Seo, Je Kyung Seong, Hae-Sol Shin, Toshihiko Shiroishi, Tania Sorg, Michelle Stewart, Masaru Tamura, Heather Tolentino, Uchechukwu Udensi, Sara Wells, Wolfgang Wurst, Atsushi Yoshiki, Hamid Meziane, Glenn Yiu, Paul A Sieving, Louise Lanoue, K C Kent Lloyd, Colin Mckerlie, Ala Moshiri, International Mouse Phenotyping Consortium (Impc)

Center for Medical Ethics and Health Policy Staff Publications

Purpose: Analyze phenotypic data from knockout mice with late-adult retinal pathologic phenotypes to identify genes associated with development of adult-onset retinal diseases.

Methods: The International Mouse Phenotyping Consortium (IMPC) database was queried for genes associated with abnormal retinal phenotypes in the late-adult knockout mouse pipeline (49-80 weeks postnatal age). We identified human orthologs and performed protein-protein analysis and biological pathways analysis with known inherited retinal disease (IRD) and age-related macular degeneration (AMD) genes using Search Tool for the Retrieval of Interacting Genes/Proteins (STRING), PLatform for Analysis of single cell Eye in a Disk (PLAE), Protein Analysis Through Evolutionary Relationships (PANTHER), …

Iron Deficiency Without Anemia And Reduced Basal Ganglia Iron Content In Youths, Dimitri Fiani, Joo-Won Kim, Mianzhi Hu, Ramiro Salas, Sarah Heilbronner, Jacquelyn Powers, Muhammad Haque, Stephanie Dinh, Xiaofan Huang, Darrell Worthy, Sridevi Devaraj, Junqian Xu, Chadi Calarge

Faculty, Staff and Students Publications

Importance: Although brain iron is necessary for neurogenesis, myelination, and neurotransmitter synthesis, iron deficiency (ID) is defined solely based on hematological outcomes.

Objective: To examine the association of ID without anemia with basal ganglia (BG) iron content and its structural and functional sequelae in adolescents.

Design, setting, and participants: This cross-sectional study enrolled participants using the electronic medical record system from a large network of pediatrics clinics between December 2020 and April 2024. Otherwise healthy, unmedicated participants aged 10 to 17 years with a depressive or anxiety disorder or with no psychopathology were consecutively enrolled. Anemia and acute inflammation led …

The Use Of Biased Language In The Care Of Seriously Ill Children: A Pilot Study, Terri Major-Kincade, Erin Kim, Cameron A Price, Ankona Banerjee, Nikashia Franklin, Israel Castañeda Almendárez, Jaime Jump, Jared Rubenstein, Jill Ann Jarrell

Faculty, Staff and Students Publications

Background

Objective

Setting/Participants

Intraosseous Vs Intravenous Access For Epinephrine In Pediatric Out-Of-Hospital Cardiac Arrest, Masashi Okubo, Sho Komukai, Junichi Izawa, Sunhee Chung, Cameron Dezfulian, Francis X Guyette, Joshua R Lupton, Christian Martin-Gill, Sylvia Owusu-Ansah, Sriram Ramgopal, Clifton W Callaway

Faculty, Staff and Students Publications

Importance: While epinephrine is commonly administered in children with out-of-hospital cardiac arrest (OHCA) via an intraosseous (IO) or intravenous (IV) route, the optimal route of epinephrine delivery is unclear.

Objective: To evaluate the association between the route of epinephrine administration (IO or IV) and patient outcomes after pediatric OHCA.

Design, setting, and participants: Retrospective cohort study of pediatric patients (aged < 18 years) with nontraumatic OHCA treated by emergency medical services who received prehospital epinephrine either via an IO or IV route. Patients were included in the Resuscitation Outcomes Consortium Epidemiologic Registry, a prospective OHCA registry at 10 sites in the US and Canada from April 2011 to June 2015. Data analysis was performed from May 2024 to April 2025.

Exposure: Epinephrine administration route: IO or IV route.

Main outcomes and measures: The primary outcome was survival to hospital discharge. The secondary outcome was return of spontaneous circulation (ROSC) before hospital arrival. Propensity scores were calculated and inverse probability of …

Multicenter Validation Of A Machine Learning Model For Surgical Transfusion Risk At 45 Us Hospitals, Sunny S Lou, Sayantan Kumar, Charles W Goss, Michael S Avidan, Sachin Kheterpal, Thomas Kannampallil, Multicenter Perioperative Outcomes Group

2020-Current year OA Pubs

IMPORTANCE: Accurate estimation of surgical transfusion risk is important for perioperative planning and effective resource allocation. Most machine learning models in health care are not validated or perform poorly in external settings.

OBJECTIVE: To externally validate a publicly available machine learning algorithm (Surgical Personalized Anticipation of Transfusion Hazard [S-PATH]) to estimate red cell transfusion during surgery within a national sample of hospitals.

DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study evaluated all surgical cases performed in 2020 or 2021 at 45 US hospitals participating in the Multicenter Perioperative Outcomes Group. Obstetric and nonoperative cases were excluded. Data analysis was performed …

Cytarabine Pharmacogenomics And Outcomes Among Children And Young Adults With Acute Myeloid Leukemia, Richard J Marrero, Geoffrey L Uy, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Therapeutic responses in acute myeloid leukemia (AML) demonstrate considerable variability both across and within established risk stratifications and age groups. Moreover, significant racial disparities persist, with Black patients experiencing inferior survival outcomes compared with their White counterparts.

OBJECTIVE: To validate the association of the previously reported 10 single nucleotide variant (SNV)-based ara-C pharmacogenomics score (ACS10) with survival outcomes in a large cohort of pediatric AML patients; to evaluate whether ACS10 remains relevant in an adolescent and young adult (AYA) population of patients with AML treated with similar intensive induction chemotherapy protocols; and to assess the association of ACS10 with …

Using “Ways Of Thinking And Practising” To Analyse Final Year Medical Student Reflections And Underlying Concepts In Preparedness For Practice, Rachel Leyland, Hilary Neve, Elizabeth Drake, Tracey Collett

Peninsula Medical School

Introduction: Ensuring that medical students are prepared for future practice is challenging for all medical schools. Most studies of preparedness involve newly qualified doctors and use quantitative methods such as self-report surveys focused on defined competencies, and often find graduates are unprepared for the complex and challenging areas of real-world practice. Qualitative methods, using conceptual ideas linked to learning such as ‘Ways of Thinking and Practising’ (WTP) are little explored in this area but could offer rich and useful insights about graduates’ preparedness. WTP recognises that, in addition to specific knowledge and skills, students need to understand the complex links …

Research Misconduct Sebagai Suatu Tindak Pidana Penyebaran Berita Bohong: Sebuah Tinjauan Hukum Pidana, Kemal Fikri Royadi, Monte Carlo Faza Harissa

Jurnal Hukum & Pembangunan

Research is one of the gates to uncover wisdom in scientific disciplines. In its implementation, it is often found that there are various interests underlying the research. These various interests also have their own purpose to the extent that it can influence the results of the research which can have implications to form a research misconduct. This research aims to review the national criminal law regarding this behavior by examining the relevant act’s articles as well as scholarly dogmatics due to the absence of laws regulating this matter. The method used in this research is juridical-normative using conceptual approach and …