Digital Commons Network^™

2025-06-04 The Central District’S New Garfield Superblock: Gentrification Or Greater Good?, Kayla Okonu

The Spectator Online

No abstract provided.

Advances In Molecular Imaging Of Vegfrs: Innovations In Imaging And Therapeutics, Hanieh Karimi, Sarah Lee, Wenqi Xu, Sigrid A. Langhans, David K. Johnson, Erik Stauff, Heidi H. Kecskemethy, Lauren W. Averill, Xuyi Yue

Department of Radiology Faculty Papers

Vascular endothelial growth factor receptors (VEGFRs) are key regulators of angiogenesis, lymphangiogenesis, and vascular permeability, playing essential roles in both physiological and pathological processes. The VEGFR family, including VEGFR-1, VEGFR-2, and VEGFR-3, interacts with structurally related VEGF ligands (VEGFA, VEGFB, VEGFC, VEGFD, and placental growth factor [PlGF]), activating downstream signaling pathways that mediate critical cellular processes, including proliferation, migration, and survival. Dysregulation of VEGFR signaling has been implicated in numerous diseases, such as cancer, cardiovascular conditions, and inflammatory disorders. Targeting VEGFRs with radiopharmaceuticals, such as radiolabeled peptides, antibodies, and specific tracers like 64Cu-bevacizumab and 89Zr-ramucirumab, has emerged as a powerful …

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final 2025 Residential Metals Abatement Program (Rmap) Rock Creek Cattle Company Borrow Submittal #1 (Dated May 23, 2025), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Student Use Of Public Access Computers In The Library: A 10-Year Comparison Study, Holt Zaugg

Faculty Publications

Why did you do this activity, project, or research?

In 2014, across the BYU campus, the use of student-accessible public computer labs was declining. At this time, the library was not experiencing this decline; rather, public computer use in the library was increasing. Ten years later, we re-administered a similar survey in the same manner to determine what, if any, changes occurred.

How did you do this?

Initially (2014), we used a pop-up survey to help determine similarities and differences. When students logged on to a library computer, an invitation to participate in the survey popped up with the option …

Ronald Johnson

African American Funeral Programs

Ronald_Johnson.pdf - Funeral program for Ronald Johnson

Autism Spectrum Disorder-Specific Knowledge And Self-Efficacy Among Early Interventionists In Alabama, Greta R. Conlon

All ETDs from UAB

Young children diagnosed with autism and those who will go on to receive an autism diagnosis are frequently enrolled in early intervention services under Part C of IDEA. ASD-specific knowledge and self-efficacy have been shown to vary among providers working with autistic children, including those providing early intervention services (i.e., early interventionists). The current study aimed to characterize ASD-specific knowledge and self-efficacy in a sample of early interventionists in Alabama. In addition, it sought to identify differences in knowledge and self-efficacy between early interventionists serving different roles and to identify predictors of identified knowledge levels and self-efficacy ratings among participants. …

Development Of Aldot's Worker Safety Assessment, Risk Identification, And Control Program, Lana Marji

All ETDs from UAB

This research examines the safety challenges faced by Transportation Maintenance Technicians (TMTs) at the Alabama Department of Transportation (ALDOT). By ana-lyzing extensive injury data from 2009 to 2024, along with insights from surveys and interactions with ALDOT personnel, this effort highlights significant trends and relation-ships among injury characteristics such as nature, cause, source, and affected body parts. The findings reveal considerable costs and productivity losses associated with common injury types that warrant the need for targeted interventions. By reviewing successful safety programs across various state Departments of Transportation (DOTs), the study identifies opportunities to enhance safety within ALDOT. This effort …

Best Practices For Preparing Urban High School Students For College Readiness, Chin Nou Khang

Graduate Teacher Education

Low-income urban students in the United States exhibit limited college and career readiness opportunities (Yavuz et al., 2019). College preparation coursework and career training in low-income urban secondary settings are essential to creating inclusivity in education. The disparities of marginalized students in these institutions highlight the urgency for educational leaders to effectively produce the next generation of student achievement. This meta-analysis secondary research paper examined the best practices for educational leaders to ensure college and career readiness opportunities are being implemented for low-income urban high school students. When students have access to college readiness materials, their scholastic goals can be …

Association Between Microsatellite Loci And Body Weight Over Generations Of Selection For Growth In Local Selected Chicken Lines, Mariam S. Orabi, Essam A. El-Gendy, Ahmed M. El-Kaiaty, Ellham H. Abbas, Marwa M. Ahmed, Mostafa M. Helal

Turkish Journal of Veterinary & Animal Sciences

The genetic improvement of local chicken breeds is essential for sustainability and adaptability. Marker-assisted breeding can increase the response to selection; however, it requires the identification of marker associations with different traits. Therefore, the current study aimed to evaluate the association between microsatellite marker alleles and the body weight of juvenile chicks over three subsequent generations. Ten microsatellites were used to genotype four chicken lines (two selected and two randombred) across three generations. The lines included the normally feathered selected line (CE1), the normally feathered randombred line (CE2) used as a genetic control for CE1, the naked-neck selected line (CE3), …

Nitrate And Nitrite Levels In Cattle Feed, Drinking Water, Rumen Content, And Blood Methemoglobin Levels In Burdur Province Of Türkiye, Reyda Kiyici, Hasan Altan Akkan, Mehmet Karaca, Esra Zeybek, Bayram Kudret Karaayvaz, Fi̇rdevs Mor Savaş, Yahya Öztürk, Asim Kart, Ramazan Yildiz, Murat Bayezi̇t

Turkish Journal of Veterinary & Animal Sciences

This study was conducted to determine the risk factors associated with nitrate/nitrite poisoning in cattle in the Burdur region. Feed and water samples were collected from 10 different farms randomly selected from 9 districts. A total of 33 feed samples, 13 water samples, 21 rumen contents, and 20 blood samples were collected for analysis. Nitrate and nitrite levels in feed, drinking water, and rumen fluid, as well as methemoglobin levels in blood samples, were determined using a spectrophotometric method. The average nitrate and nitrite levels in feed samples were 3.06 mg/kg and 3.54 mg/kg, respectively. The mean nitrate and nitrite …

Inga V. Revenco

All Decisions

The court partially granted the landlord's motion to amend the petition to include GCEL applicability and good cause grounds, and partially granted the tenant's motion to amend her answer. It denied the tenant's motion to dismiss outright. While the initial predicate notice served before GCEL's enactment was valid, the petition filed afterward needed to conform. The court allowed the landlord to proceed on the **non-payment of rent** ground, finding it sufficiently pleaded with specific amounts and dates, but dismissed the **nuisance** and **illegal sublet** grounds due to lack of factual specificity in the petition.

Kings Vil. Corp. V. Pascal

All Decisions

The court granted the tenant's motion to dismiss the nonpayment petition, finding the rent demand defective due to the inclusion of substantial lump-sum charges lacking specific periods of accrual. While the court noted that fees and non-rent charges are permissible in co-op nonpayment cases if allowed by the proprietary lease, the large "Prior Agent" lump sums for maintenance, assessment, and parking rendered the demand insufficient to "fairly appraise" the tenant of the arrears, thus undermining the proceeding. The dismissal was without prejudice.

Deep Learning Based Rapid X-Ray Fluorescence Signal Extraction And Image Reconstruction For Preclinical Benchtop X-Ray Fluorescence Computed Tomography Applications, Amrit Kaphle, Sandun Jayarathna, Sang Hyun Cho

Faculty, Staff and Student Publications

Recent research advances have resulted in an experimental benchtop X-ray fluorescence computed tomography (XFCT) system that likely meets the imaging dose/scan time constraints for benchtop XFCT imaging of live mice injected with gold nanoparticles (GNPs). For routine in vivo benchtop XFCT imaging, however, additional challenges, most notably the need for rapid/near-real-time handling of X-ray fluorescence (XRF) signal extraction and XFCT image reconstruction, must be successfully addressed. Here we propose a novel end-to-end deep learning (DL) framework that integrates a one-dimensional convolutional neural network (1D CNN) for rapid XRF signal extraction with a U-Net model for XFCT image reconstruction. We trained …

Olaparib And Radiotherapy Induce Type I Interferon- And Cd8+ T Cell-Dependent Sensitization To Immunotherapy In Pancreatic Cancer, Victoria M Valvo, Qiang Zhang, Long Jiang, Erin A Holcomb, Ashley N Pearson, Anna G Edmunds, Hailey G Faulkner, Jadyn G James, Akshay Tate, Amanda K Huber, Zhuwen Wang, Yupei Guo, David Karnak, Leslie A Parsels, Joshua D Parsels, Yu L Lei, Alnawaz Rehemtulla, Heng Lin, Eileen S Carpenter, Daniel R Wahl, Vaibhav Sahai, Theodore S Lawrence, Michael D Green, Meredith A Morgan

Faculty, Staff and Student Publications

PARP inhibitors sensitize pancreatic ductal adenocarcinoma (PDAC) to radiation by inducing DNA damage and replication stress. These mechanisms also have the potential to enhance radiation-induced type I interferon (T1IFN) mediated anti-tumoral immune responses. We hypothesized that the PARP inhibitor olaparib would also potentiate radiation-induced T1IFN to promote anti-tumor immune responses and sensitization of otherwise resistant PDAC to immunotherapy. To test this hypothesis, we assessed the effects of olaparib and radiation on T1IFN production and sensitivity to αPD-L1 immunotherapy, as well as on the tumor microenvironment by single-cell RNA sequencing (scRNA-seq). We found that olaparib enhanced T1IFN production following radiation and …

Polygenic Scores For Obstructive Sleep Apnoea Reveal Pathways Contributing To Cardiovascular Disease, Nuzulul Kurniansyah, Satu J Strausz, Geetha Chittoor, Shreyash Gupta, Anne E Justice, Yana Hrytsenko, Brendan T Keenan, Brian E Cade, Brian W Spitzer, Heming Wang, Jennifer Huffman, Matthew R Moll, Bernhard Haring, Su Yon Jung, Laura M Raffield, Robert Kaplan, Jerome I Rotter, Stephen S Rich, Sina A Gharib, Traci M Bartz, Peter Y Liu, Han Chen, Myriam Fornage, Lifang Hou, Daniel Levy, Alanna C Morrison, Heather M Ochs-Balcom, Bruce M Psaty, Peter W F Wilson, Kelly Cho, Allan I Pack, Hanna M Ollila, Susan Redline, Daniel J Gottlieb, Tamar Sofer

Faculty, Staff and Student Publications

Background: Obstructive sleep apnoea (OSA) is a common chronic condition, with obesity its strongest risk factor. Polygenic scores (PGSs) summarise the genetic liability to phenotype and can provide insights into relationships between phenotypes. Recently, large datasets that include genetic data and OSA status became available, providing an opportunity to utilise PGS approaches to study the genetic relationship between OSA and other phenotypes, while differentiating OSA-specific from obesity-specific genetic factors.

Methods: Using race/ethnic diverse samples from over 1.2 million individuals from the Million Veteran Program, FinnGen, TOPMed, All of Us (AoU), Geisinger's MyCode, MGB Biobank, and the Human Phenotype Project, we …

Lmp7-Specific Inhibitor M3258 Modulates The Tumor Microenvironment Of Triple-Negative Breast Cancer And Inflammatory Breast Cancer, Xuemei Xie, Jangsoon Lee, Ganiraju C Manyam, Troy Pearson, Gina Walter-Bausch, Manja Friese-Hamim, Sheng Zhao, Julia Jabs, Angela A Manginelli, Nadine Piske, Thomas Mrowiec, Corinna M Wolf, Bharat S Kuntal, Debu Tripathy, Jing Wang, Michael P Sanderson, Naoto T Ueno

Faculty, Staff and Student Publications

Triple-negative breast cancer (TNBC) and inflammatory breast cancer (IBC) are the most aggressive molecular subtypes of breast cancer. Poor clinical outcomes highlight the pressing need to discover novel targets for the effective treatment of these diseases. LMP7 (β5i/PSMB8), a proteolytic subunit of the immunoproteasome, is implicated in the pathogenesis of multiple myeloma, autoimmune and inflammatory diseases, and inflammation-related cancers. However, the role of LMP7 in TNBC and IBC remains poorly characterized. Here, we evaluated the function of LMP7 in TNBC and IBC using the selective LMP7 inhibitor M3258. In human TNBC patient samples, LMP7 expression correlated strongly with CD8+ T …

Eph Receptors Activate Myeloid Checkpoint Receptor Lilrb5 To Support Tumor Development, Yubo He, Chengcheng Zhang, Lingxiao Tan, Mi Deng, Xiaoye Liu, Ryan Huang, Xing Yang, Jingjing Xie, Qi Lou, Meng Fang, Caroline Smith, Samuel John, Wei Xiong, Xin Li, Cheryl Lewis, Jade Homsi, Ankit Gupta, Ningyan Zhang, Zhiqiang An, Cheng Cheng Zhang

Faculty, Staff and Student Publications

Immunosuppressive myeloid cells are critical obstacles to T cell-centered immune checkpoint blockade therapies, which have been successful in treating a fraction of patients with cancer. How tumor cells interact with myeloid cells to regulate immune responses and tumor development is unclear. In this study, we report that certain membrane tyrosine kinase Eph receptors, including EphA7 and EphB1, specifically bind the immune inhibitory receptors leukocyte Ig-like receptor family B 5 (LILRB5) and LILRB2. These Eph receptors induce LILRB5-mediated signaling activation, and LILRB5 also activates Eph receptor signaling. Activation of LILRB5 promoted immunosuppressive marker expression and inhibited activating marker expression on myeloid …

The Present And Future Of Precision Oncology And Tumor-Agnostic Therapeutic Approaches, Nakul M Shah, Funda Meric-Bernstam

Faculty, Staff and Student Publications

Precision oncology has transformed the treatment landscape for patients with advanced solid tumors. Tumor-agnostic therapies, those that have been approved based on genetic mutations or biomarkers across tumor histology types, are important examples of how the implementation of precision oncology can expand therapeutic options for patients, especially those with rare cancer types and treatment-refractory disease. In this review, we first discuss how advances in next-generation sequencing and molecular profiling have enabled the identification of shared actionable alterations. Subsequently, we explore the current landscape of tumor-agnostic therapies that have received approval from the Food and Drug Administration. We discuss the strengths …

Deep Learning Based Rapid X-Ray Fluorescence Signal Extraction And Image Reconstruction For Preclinical Benchtop X-Ray Fluorescence Computed Tomography Applications, Amrit Kaphle, Sandun Jayarathna, Sang Hyun Cho

Faculty, Staff and Student Publications

Recent research advances have resulted in an experimental benchtop X-ray fluorescence computed tomography (XFCT) system that likely meets the imaging dose/scan time constraints for benchtop XFCT imaging of live mice injected with gold nanoparticles (GNPs). For routine in vivo benchtop XFCT imaging, however, additional challenges, most notably the need for rapid/near-real-time handling of X-ray fluorescence (XRF) signal extraction and XFCT image reconstruction, must be successfully addressed. Here we propose a novel end-to-end deep learning (DL) framework that integrates a one-dimensional convolutional neural network (1D CNN) for rapid XRF signal extraction with a U-Net model for XFCT image reconstruction. We trained …

Mesenchymal Stem Cells And Fibroblasts Contribute To Microvascular Proliferation In Glioblastoma And Are Correlated With Immunosuppression And Poor Outcome, Candice C Poon, Shelley M Herbrich, Yulong Chen, Anwar Hossain, Gregory N Fuller, Sonali Jindal, Sreyashi Basu, Daniel Ledbetter, Marc Macaluso, Lynnette M Phillips, Joy Gumin, Zhong He, Brittany C Parker Kerrigan, Sanjay K Singh, Pratishtha Singh, Mohammed Fayyad Zaman, Derek Ng Tang, Sangeeta Goswami, Frederick F Lang, Padmanee Sharma

Faculty, Staff and Student Publications

Microvascular proliferation (MVP) is a disease-defining hallmark of glioblastoma and other World Health Organization grade 4 gliomas. MVP also serves as a poor prognostic marker in various solid tumors. Despite its clinical significance, the mechanisms and biological consequences of MVP are controversial and remain unclear. In this study, we performed single-cell RNA sequencing on paired CD45-CD105+ vascular/perivascular stromal cells (PVSC) and CD45+CD105± immune cells from 16 primary glioma patient samples, both with and without MVP. This analysis revealed the presence of developmentally related mesenchymal stem cells alongside cancer-associated fibroblasts, pericytes, fibromyocytes, and smooth muscle cells within the CD45-CD105+ compartment. RNA …

Kaiso Mediates Transcription And Rna Splicing In Colorectal Carcinoma: Role Of Brca1 In The Kaiso Enhanceosome, Weifeng Luo, Manish Kumar Tripathi, Qi Liu, Lei Chen, Robert W. Cowan, Juliet M. Daniel, Chi Yan, Ann Richmond, Albert B. Reynolds

School of Medicine Publications

Kaiso (ZBTB33) is a transcription factor involved in mitotic clonal expansion and tumorigenesis in association with Adenomatous Polyposis Coli (APC) loss of heterozygosity. ENCODE data show strong overlap of the Kaiso promoter-binding site—encode-derived Kaiso-binding site (eKBS) and many other transcription factors, including BRCA1. Here we sought to determine whether BRCA1 is a component of the Kaiso enhanceosome that regulates gene transcription. Using proximal ligation assays, immunoprecipitation followed by mass spectrometry, luciferase assays and ChIP-seq experiments, we evaluated the association between BRCA1 and Kaiso. Kaiso nuclear extract immunoprecipitation experiments revealed that Kaiso associates strongly with genes involved in RNA splicing and …

Combining Remote And Collaborative Research: A Critical Reflection On Large-Scale, Comparative, And Interdisciplinary Research In Times Of A Global Crisis, Ferdiansyah Thajib, Thomas Stodulka, Patricia Kanngiesser, Daniel Haun, Jahnavi Sunderarajan, Magie Junker, Tongtong Meng, Wanting Sun, Zhen Zhang, Sandra Masaquiza, Monika Swastyastu, Desri Julita Taek, Arianna Abis, Disney Tjizao, Denis Chishala, Ljubica Petrović, Blanca Striegler, Janina Weyrowitz, Bernardo Arroyo-Garcia, Katja Liebal

School of Psychology

This paper examines the methodological and ethical challenges of conducting remoteresearch on child-animal relationships across thirty communities in seventeen countriesduring the COVID-19 pandemic. It critically assesses remote research as a mode ofcollaboration informed by decolonial aspirations, highlighting the complexities of navigatingtemporal and geographical distances, mitigating global inequalities, and addressing politicaland methodological tensions at the intersection of psychological anthropology and crosscultural developmental psychology. By engaging with these challenges, the paper fosterscritical dialogue on research ethics and methodologies between anthropology andpsychology, advancing a broader intellectual engagement toward translocal equity

Histological And Histochemical Study Of The Salt Glands In Geese (Anser Anser): Are There Receptor Cells In Salt Glands?, Şahi̇n Aslan, Di̇lem Gülece Ermutlu, Serap İlhan Aksu, Serap Koral Taşçi, Turgay Deprem

Turkish Journal of Veterinary & Animal Sciences

The regulation of solutes occurs not through the skin but via salt glands located in the nose and kidneys in reptiles and birds. This study aimed to investigate and elucidate the histological structure of the salt glands in domestic geese, and to characterize their ducts and cellular components in detail.Crossmon’s triple staining technique, hematoxylin and eosin (H&E), periodic acid-Schiff (PAS), combined alcian blue, and Kluver– Barrera stains were used for the histological investigations.The outer surface of the organ was enclosed by connective tissue, and the capsule subdivided the tissue into bulbs. Nerve fibers and endings were observed within the capsule …

Re: Comment Letter For The Butte Priority Soils Operable Unit (Bpsou) 2022 Draft Final Insufficiently Reclaimed Sites Sampling: Bres No. 37 – Josephine Shaft Site Evaluation Summary Report (December 6, 2024), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Lindenwood Digest, June 4, 2025, Lindenwood University

Lindenwood Digest

The Lindenwood Digest has been a digital employee newsletter since 2009.

Building Models, Building Capacity: A Review Of Participatory Machine Learning For Hiv Prevention, Mark Sendak, Meg Young, Jee Young Kim, Alifia Hasan, Clare Kelsey, Catherine O’Neal, Tonya Jagneaux, Wayne Wilbright, John Couk, Stephen Lim, Tamachia Davenport, Shirley Lolis, Jennifer Thomas, Shannon Widman, Suresh Balu, Meredith Clement, Lance Okeke

School of Medicine Faculty Publications

A growing number of researchers and practitioners are embracing a “participatory turn” in machine learning (ML) to improve model development, prevent harm, and provide communities more influence over systems that impact them. In this paper, we explore the intersection of participatory practices in healthcare and the emerging focus on responsible AI with a focus on human immunodeficiency virus (HIV) care. We review the historical context of participation in HIV treatment and prevention, emphasizing how patient activism has shaped practices in this field. We then review participatory ML in HIV prevention and present a brief case study of a project designed …

Prediction Of Methotrexate Neurotoxicity Using Clinical, Sociodemographic, And Area-Based Information In Children With Acute Lymphoblastic Leukemia, Rachel D Harris, Olga A Taylor, Maria Monica Gramatges, Amy E Hughes, Mark Zobeck, Sandi Pruitt, M Brooke Bernhardt, Ashley Chavana, Van Huynh, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Ashley Choi, Yuu Ohno, Melissa A Richard, Alanna C Morrison, Han Chen, Bing Yu, Philip J Lupo, Karen R Rabin, Michael E Scheurer, Austin L Brown

Center for Medical Ethics and Health Policy Staff Publications

Background: Methotrexate is a critical component of pediatric acute lymphoblastic leukemia (ALL) therapy that can result in neurotoxicity which has been associated with an increased risk of relapse. We leveraged machine learning to develop a neurotoxicity risk prediction model in a diverse cohort of children with ALL.

Methods: We included children (age 2-20 years) diagnosed with ALL (2005-2019) and treated in Texas without pre-existing neurologic disease. Clinical information was obtained by medical record review. Neurotoxicity occurring post-induction and prior to maintenance therapy was defined as neurologic episodes occurring within 21 days of methotrexate. Suspected cases were independently confirmed by 2 …

Cross-Sectional Analysis Of Wound-Associated Soluble Factors In Early, Established, And Chronic Wounds Of Recessive Dystrophic Epidermolysis Bullosa Patients, Vitali Alexeev, Leonie Huitema, Taylor Phillips, Paras Patel, Mauricio Garza, Franziska Ringpfeil, Julio Salas-Alanis, Olga Igoucheva

Department of Dermatology and Cutaneous Biology Faculty Papers

BACKGROUND: Poorly healing wounds represent the primary health-related burden for hereditary recessive dystrophic epidermolysis bullosa (RDEB) patients. Contribution of wound-associated soluble constituents to wound progression remains not well defined.

OBJECTIVE: To conduct cross-sectional analysis of cytokine, chemokine, and growth factor in exudates from RDEB wounds and define changes associated with wound progression.

METHODS: Concentrations of selected cytokines, chemokines, and growth factors were evaluated by multiplex ELISA in eight blister fluids and 66 exudates from early, established, and chronic RDEB and five chronic venous ulcers (VU). A cross-sectional analysis was performed.

RESULTS: Our data demonstrated that proinflammatory CXCL8 and IL-1β tend …

Direct Upcycling Of Degraded Ncm Via Low-Temperature Surface Engineering For High Performance Lithium-Ion Batteries, Yu Wang, Chris Yuan

Faculty Scholarship

Upcycling degraded low-Ni cathode materials into Ni-rich alternatives offers significant economic and environmental benefits for lithium-ion battery production. However, the stability and safety of the upcycled materials remain challenging due to their aggressive composition. This study reports an innovative two-step upcycling method that integrates a coating process with a low-temperature annealing process, thereby successfully upcycling degraded NCM622 with a LiAlO2 coating layer. Through comprehensive characterization, the recovery of crystal structure and uniform LiAlO2 coating on the particle surface are confirmed by XRD and XPS results. As a result of structural recovery and surface engineering, upcycled NCM622 demonstrates an initial capacity …

Oxygen Saturation Targeting In The Neonatal Intensive Care Unit, Faeq Almudares, Bheru Gandhi, Jonathan Davies, Xanthi Couroucli, Natalie Villafranco, Nidhy Paulose Varghese, Milenka Cuevas Guaman, Charleta Guillory, Binoy Shivanna

Faculty, Staff and Students Publications

Oxygen (O2) is vital for cellular development, function, proliferation, and repair, underscoring its critical role in organogenesis. Both hypoxia (reduced tissue O2) and hyperoxia (excess tissue O2), when prolonged, can trigger inflammation and oxidative stress, contributing to acute and long-term cardiopulmonary and neurodevelopmental morbidity. In sick neonates, immature defense mechanisms and coexisting morbidities demand nuanced and sometimes opposing strategies for O2 saturation targets and therapeutic titration. Most current neonatal O2 targeting guidelines are based on animal models or small clinical studies, resulting in recommendations with limited evidence. This narrative review aims to provide an updated overview of the physiological roles …