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Articles 171691 - 171720 of 5156606
Full-Text Articles in Entire DC Network
Application Of Claims-Based Frailty Index To A Structured Electronic Health Record Data, Min Ji Kwak, Caroline Schaefer, Youngran Kim, Sunyang Fu, Chan Mi Park, Abhijeet Dhoble, Nahid Rianon, Holly M Holmes, Dae Hyun Kim
Application Of Claims-Based Frailty Index To A Structured Electronic Health Record Data, Min Ji Kwak, Caroline Schaefer, Youngran Kim, Sunyang Fu, Chan Mi Park, Abhijeet Dhoble, Nahid Rianon, Holly M Holmes, Dae Hyun Kim
Faculty, Staff and Student Publications
Background: The Claims-based Frailty Index (CFI) has been developed and validated using Medicare claims data. However, whether CFI can be applied to structured electronic health record data has not been studied.
Methods: We applied the CFI to a structured electronic health record dataset (Explorys dataset) and a Medicare fee-for-service 5% sample data and compared the prevalence of frailty from each dataset, using the cohort of older adults. Then, we assessed the odds ratio and area under the curve of the frailty predicting adverse clinical outcomes, any hospital or emergency room visit, or any adverse drug events related encounter within 1 …
Status Epilepticus Protocol Variation Across Accredited National Association Of Epilepsy Centers Members., Laura K. Lamberta, Melissa Asmar, Megan M. Fredwall, Stephanie M. Ahrens, Shasha Bai, Mariah Eisner, Fred Alexander Lado, Stephan U. Schuele, Dave F. Clarke, Ahmed Abdelmoity, Kathryn A. Davis, Jennifer L. Hopp, Mohamad Z. Koubeissi, Meriem K. Bensalem Owen, Susan T. Herman, Adam P. Ostendorf, Naec Center Director Study Group
Status Epilepticus Protocol Variation Across Accredited National Association Of Epilepsy Centers Members., Laura K. Lamberta, Melissa Asmar, Megan M. Fredwall, Stephanie M. Ahrens, Shasha Bai, Mariah Eisner, Fred Alexander Lado, Stephan U. Schuele, Dave F. Clarke, Ahmed Abdelmoity, Kathryn A. Davis, Jennifer L. Hopp, Mohamad Z. Koubeissi, Meriem K. Bensalem Owen, Susan T. Herman, Adam P. Ostendorf, Naec Center Director Study Group
Manuscripts, Articles, Book Chapters and Other Papers
OBJECTIVES: Status epilepticus (SE) is a neurologic emergency that requires urgent recognition and medical management. SE management remains heterogeneous across centers.
METHODS: We analyzed SE treatment protocols from level 3 and level 4 epilepsy centers. Discrete data including stabilization measures, timing of treatment phases, medications, doses, and routes of administration were collected from each protocol and described using frequency for categorical variables and median for continuous variables. The distribution of treatment times and dosing were compared with the AES guideline.
RESULTS: A total of 256 SE treatment protocols were included. Only 66% of SE protocols detailed treatment times. Doses below …
Sickle Cell Disease Induces Chromatin Introversion And Ferroptosis In Cd8+ T Cells To Suppress Anti-Tumor Immunity, Zilong Zhao, Benxia Hu, Yalan Deng, Melinda Soeung, Jun Yao, Lanxin Bei, Yaohua Zhang, Pengju Gong, Lisa A Huang, Zhou Jiang, Jian Gao, Shuang Peng, Tina K Nguyen, Menuka Karki, Bora Lim, Cassian Yee, Jared K Burks, Qing Zhang, Li Ma, Jianjun Gao, Nizar M Tannir, Leng Han, Dihua Yu, Linghua Wang, Michael A Curran, Maria A Gubbiotti, Giannicola Genovese, Boyi Gan, Wenbo Li, Pavlos Msaouel, Liuqing Yang, Chunru Lin
Sickle Cell Disease Induces Chromatin Introversion And Ferroptosis In Cd8+ T Cells To Suppress Anti-Tumor Immunity, Zilong Zhao, Benxia Hu, Yalan Deng, Melinda Soeung, Jun Yao, Lanxin Bei, Yaohua Zhang, Pengju Gong, Lisa A Huang, Zhou Jiang, Jian Gao, Shuang Peng, Tina K Nguyen, Menuka Karki, Bora Lim, Cassian Yee, Jared K Burks, Qing Zhang, Li Ma, Jianjun Gao, Nizar M Tannir, Leng Han, Dihua Yu, Linghua Wang, Michael A Curran, Maria A Gubbiotti, Giannicola Genovese, Boyi Gan, Wenbo Li, Pavlos Msaouel, Liuqing Yang, Chunru Lin
Faculty, Staff and Student Publications
Understanding how genetic disorders affect CD8+ T cells in the tumor microenvironment is key to improving cancer immunotherapy. Individuals with sickle cell disease (SCD), the most prevalent inherited blood disorder, have a higher risk of developing certain cancers than the general population, but the mechanisms driving this increased risk remain unclear. Our study revealed that SCD altered CD8+ T cell 3D genome architecture, triggering ferroptosis and weakening anti-tumor immunity, thereby promoting tumor growth. Using murine and humanized SCD models, we found that disrupted chromosomal interactions in CD8+ T cells reduced the expression of anti-ferroptotic genes, including SLC7A11 and hydrogen sulfide …
Optimized Genomic Editing Of A Common Duchenne Muscular Dystrophy Mutation In Patient-Derived Muscle Cells And A New Humanized Mouse Model, Mateusz Z Durbacz, Yu Zhang, Hui Li, Takahiko Nishiyama, Efrain Sanchez- Ortiz, John R Mcanally, Damir Alzhanov, Ning Liu, Eric N Olson
Optimized Genomic Editing Of A Common Duchenne Muscular Dystrophy Mutation In Patient-Derived Muscle Cells And A New Humanized Mouse Model, Mateusz Z Durbacz, Yu Zhang, Hui Li, Takahiko Nishiyama, Efrain Sanchez- Ortiz, John R Mcanally, Damir Alzhanov, Ning Liu, Eric N Olson
Faculty, Staff and Student Publications
Duchenne muscular dystrophy (DMD) is a fatal X-linked, recessive disease caused by mutations in the DMD gene encoding dystrophin, a membrane-associated protein necessary for maintaining muscle structure and function. One of the common DMD mutations is the deletion of exon 52 (Δ52), which introduces a premature stop codon in exon 53, preventing the expression of functional dystrophin protein. Patients with this mutation could benefit from skipping or reframing exon 53 to restore the dystrophin open reading frame. In this study, we investigated the efficacy of single-cut CRISPR gene editing with Staphylococcus pyogenes Cas9 (SpCas9)-LRVQR to restore dystrophin expression …
Real-World Outcomes For Young Adult Patients Receiving Cd19 Car T-Cell Therapy., Hannah Lust, Liora M. Schultz, Soyang Kwon, Gregory W. Roloff, Ibrahim Aldoss, Christina Baggott, Samuel John, Jenna E. Rossoff, Kevin O. Mcnerney, Vanessa A. Fabrizio, Julie-An Talano, Amy Moskop, Kevin J. Curran, Christine L. Phillips, Nicole Karras, Susanne H C Baumeister, Stacy L. Cooper, Michelle Hermiston, Prakash Satwani, Muna Qayed, Sunil S. Raikar, Margaret Macmillan, Erin Hall, Khanh Nguyen, Ryan D. Cassaday, Noam E. Kopmar, Vamsi K. Kota, John Mathews, Paul Shaughnessy, Marc S. Schwartz, Abdullah Ladha, George Yaghmour, Muthu V. Kumaran, Veronika Bachanova, Sean Tracy, Tamer Othman, Marlise R. Luskin, Evan C. Chen, Anjani S. Advani, Nikeshan Jeyakumar, Katharine Miller, Amy Zhang, Katherine C. Sutherland, Bijal D. Shah, Lori Muffly, Rawan Faramand
Real-World Outcomes For Young Adult Patients Receiving Cd19 Car T-Cell Therapy., Hannah Lust, Liora M. Schultz, Soyang Kwon, Gregory W. Roloff, Ibrahim Aldoss, Christina Baggott, Samuel John, Jenna E. Rossoff, Kevin O. Mcnerney, Vanessa A. Fabrizio, Julie-An Talano, Amy Moskop, Kevin J. Curran, Christine L. Phillips, Nicole Karras, Susanne H C Baumeister, Stacy L. Cooper, Michelle Hermiston, Prakash Satwani, Muna Qayed, Sunil S. Raikar, Margaret Macmillan, Erin Hall, Khanh Nguyen, Ryan D. Cassaday, Noam E. Kopmar, Vamsi K. Kota, John Mathews, Paul Shaughnessy, Marc S. Schwartz, Abdullah Ladha, George Yaghmour, Muthu V. Kumaran, Veronika Bachanova, Sean Tracy, Tamer Othman, Marlise R. Luskin, Evan C. Chen, Anjani S. Advani, Nikeshan Jeyakumar, Katharine Miller, Amy Zhang, Katherine C. Sutherland, Bijal D. Shah, Lori Muffly, Rawan Faramand
Manuscripts, Articles, Book Chapters and Other Papers
Tisagenlecleucel (tisa-cel) and brexucabtagene autoleucel (brexu-cel) are approved CD19 chimeric antigen receptor T-cell therapy (CAR T) products for young adults (YA) with relapsed/refractory B-cell acute lymphoblastic leukemia. A distinct analysis of YAs receiving commercial CD19 CAR T has not been reported. Using retrospective data from the Pediatric Real-World CAR T Consortium and the Real-World Outcomes of CAR T in Adult ALL collaboration, we describe the efficacy and safety of tisa-cel and brexu-cel in 70 YAs (18-26 years; tisa-cel, n = 50; brexu-cel, n = 20). Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) were observed more frequently …
Arid4b: An Orchestrator From Stem Cell Fate To Carcinogenesis, Rakhee Rathnam Kalari Kandy, Madan Kumar Arumugam, Mukesh Pratap Yadav, Bibhuti Bhusan Mishra, Jyotika Sharma
Arid4b: An Orchestrator From Stem Cell Fate To Carcinogenesis, Rakhee Rathnam Kalari Kandy, Madan Kumar Arumugam, Mukesh Pratap Yadav, Bibhuti Bhusan Mishra, Jyotika Sharma
Faculty, Staff and Student Publications
All biological processes, from embryonic development to cancer, are tightly controlled by the interactions between genetics and epigenetics. An array of epigenetic modifications, such as DNA methylation, histone/chromatin modifications, and noncoding RNA-mediated targeting, are essential to regulate the heritable changes that occur during multiple cellular processes. A failure in proper regulation results in inappropriate gene expression that ultimately leads to pathological states. Groundbreaking advances in genomics and transcriptomics have revealed the potential involvement of epigenetics in various physiological and pathological states. The promising clinical and preclinical results shown by epigenetics drugs further underscore the central role of epigenetics in multiple …
Sickle Cell Disease Induces Chromatin Introversion And Ferroptosis In Cd8+ T Cells To Suppress Anti-Tumor Immunity, Zilong Zhao, Benxia Hu, Yalan Deng, Melinda Soeung, Jun Yao, Lanxin Bei, Yaohua Zhang, Pengju Gong, Lisa A Huang, Zhou Jiang, Jian Gao, Shuang Peng, Tina K Nguyen, Menuka Karki, Bora Lim, Cassian Yee, Jared K Burks, Qing Zhang, Li Ma, Jianjun Gao, Nizar M Tannir, Leng Han, Dihua Yu, Linghua Wang, Michael A Curran, Maria A Gubbiotti, Giannicola Genovese, Boyi Gan, Wenbo Li, Pavlos Msaouel, Liuqing Yang, Chunru Lin
Sickle Cell Disease Induces Chromatin Introversion And Ferroptosis In Cd8+ T Cells To Suppress Anti-Tumor Immunity, Zilong Zhao, Benxia Hu, Yalan Deng, Melinda Soeung, Jun Yao, Lanxin Bei, Yaohua Zhang, Pengju Gong, Lisa A Huang, Zhou Jiang, Jian Gao, Shuang Peng, Tina K Nguyen, Menuka Karki, Bora Lim, Cassian Yee, Jared K Burks, Qing Zhang, Li Ma, Jianjun Gao, Nizar M Tannir, Leng Han, Dihua Yu, Linghua Wang, Michael A Curran, Maria A Gubbiotti, Giannicola Genovese, Boyi Gan, Wenbo Li, Pavlos Msaouel, Liuqing Yang, Chunru Lin
Faculty, Staff and Student Publications
Understanding how genetic disorders affect CD8
Toward Culturally Responsive Interpretation: Native American Histories, Lifeways, And Ways Of Knowing At The High Desert Museum, Carol Fitzsimmons, Ajena Cason Rogers
Toward Culturally Responsive Interpretation: Native American Histories, Lifeways, And Ways Of Knowing At The High Desert Museum, Carol Fitzsimmons, Ajena Cason Rogers
Dissertations
Many public museums and historic institutions reflect settler colonial culture and are primarily non-Native led. Although these institutions are trusted, many have perpetuated cultural harm through the theft of belongings, the misrepresentation of stories and histories, and the inaccurate portrayals of cultural content. When interpreting Native American experiences, many non-Native institutions struggle to co-create culturally responsive interpretation. The purpose of this basic qualitative study was to apply the four-truth framework, developed by the South African Truth and Reconciliation Commission, to better understand how the High Desert Museum approached the interpretation of Native American content and stories and to explore how …
Modeling And Simulation Of Tensegrity Structures With Continuous Cables, Austin R. Brown
Modeling And Simulation Of Tensegrity Structures With Continuous Cables, Austin R. Brown
Theses and Dissertations
This thesis presents a novel approach for modeling and simulating tensegrity structures with continuous cables. A Python-based simulation framework package was developed to address limitations in existing tensegrity modeling software, particularly the inability to model cables passing through multiple nodes. The framework utilizes virtual work methods to solve for equilibrium configurations of 2D, 2.5D and 3D tensegrity systems. Key features include: • A YAML-based input system for easy definition of tensegrity topologies. • Algorithms for handling continuous cables spanning multiple nodes. • Optimization techniques to find stable equilibrium states. • Capability to simulate 2.5D structures wrapped around cylindrical surfaces. • …
Brief Of Legal Ethics Scholars As Amici Curiae In Support Of Petitioner, Susan D. Carle
Brief Of Legal Ethics Scholars As Amici Curiae In Support Of Petitioner, Susan D. Carle
Amicus Briefs & Court Filings
Amici curiae are leading legal ethics scholars with expertise regarding the rules, precedents, and other authorities regarding the professional responsibility and legal ethics obligations of lawyers. While this case involves protection of crucial Sixth Amendment rights of criminal defendants, it also implicates the professional responsibility and legal ethics obligations of attorneys representing clients at trial. Amici have a professional interest in ensuring that the Court is fully informed of the important professional responsibility and legal ethics issues in this case. Specifically, amici submit this brief to explain that the trial court's order in this case creates significant and serious problems …
2025 Hillsborough County Agricultural Fair 4-H Animal Shows, Carrie A. Finke
2025 Hillsborough County Agricultural Fair 4-H Animal Shows, Carrie A. Finke
UNH Cooperative Extension
No abstract provided.
Clifford Ward
African American Funeral Programs
Clifford_Ward.pdf - Funeral program for Clifford Ward
Perchlorate Brine Formation From Frost At The Viking 2 Landing Site, Vincent F. Chevrier
Perchlorate Brine Formation From Frost At The Viking 2 Landing Site, Vincent F. Chevrier
Geosciences Faculty Publications and Presentations
The presence and stability of brines on Mars’s surface remain a significant mystery in planetary exploration. Previous mechanisms proposed for brine formation include melting of ice-salt mixtures and salt deliquescence. However, melting lacks a recharge mechanism, and deliquescence is impeded by Mars’s extreme surface aridity. This study explores an underexplored process: the role of seasonal frost in brine formation. Utilizing meteorological data from the Viking 2 lander—the only mission, with Phoenix, to observe in situ water frost formation—I demonstrate that brines can form over approximately 30 sols at the end of winter as frost sublimates. The stable brines exhibit a …
A Fifty-Year Assessment Of Historical Planning Processes And Green Space Distribution (1975-2025): A Case Study Of Portland, Or, Usa, Quadri Olatunbosun Taiwo
A Fifty-Year Assessment Of Historical Planning Processes And Green Space Distribution (1975-2025): A Case Study Of Portland, Or, Usa, Quadri Olatunbosun Taiwo
Dissertations and Theses
The Portland study examined past planning regulations and greenspace distribution over the period of fifty years, with particular attention given to neighborhood differences between invested and non-invested neighborhoods. This research utilized a mixed-methods approach through the synthesis of qualitative themes from oral narratives and archival records. Furthermore, I examined spatial greenspace using Normalized Difference Vegetation Index (NDVI) imagery. I tested the study hypothesis using the GIS Ordinary Least Squares (OLS) regression test to predict how key sociodemographic characteristics affect the provision of greenspace in non-white disinvested neighborhoods. The key findings indicated a consistent trend of inequity in greenspace, heavily shaped …
Loss Of Methyltransferase And Hypomethylated M6a Sarcomere Transcripts Leading To Early-Onset Dilated Cardiomyopathy, Sophie Marie Hand, Yi Zhao, Donna Li, Savanna Burke, Hee-Woong Lim, Jessie Yester, Vidu Garg, Federica Accornero, Xiao Li, Deqiang Li, Jihyun Jang
Loss Of Methyltransferase And Hypomethylated M6a Sarcomere Transcripts Leading To Early-Onset Dilated Cardiomyopathy, Sophie Marie Hand, Yi Zhao, Donna Li, Savanna Burke, Hee-Woong Lim, Jessie Yester, Vidu Garg, Federica Accornero, Xiao Li, Deqiang Li, Jihyun Jang
Faculty, Staff and Students Publications
No abstract provided.
Exposure-Response Relationship Of Household Air Pollution On Body Mass Index Among Women In Rural Areas Of Guatemala, India, Peru And Rwanda: Household Air Pollution Intervention Network Trial, Adolphe Ndikubwimana, Lisa De Las Fuentes, Victor G Dávila-Román, Et Al.
Exposure-Response Relationship Of Household Air Pollution On Body Mass Index Among Women In Rural Areas Of Guatemala, India, Peru And Rwanda: Household Air Pollution Intervention Network Trial, Adolphe Ndikubwimana, Lisa De Las Fuentes, Victor G Dávila-Román, Et Al.
2020-Current year OA Pubs
BACKGROUND: Household air pollution from burning biomass materials, the main cooking fuel in low- and middle-income countries, may be linked to metabolic dysfunction. We assessed cross-sectional associations between household air pollution and body mass index (BMI), expecting to see increased BMI with higher pollution concentrations.
METHODS: We analyzed data from 414 women aged 40 to 79 years who resided in the households using biomass fuel and were enrolled in the multi-country Household Air Pollution Intervention Network (HAPIN) Trial. We explored associations of 24-h average personal exposure to fine particulate matter (PM
RESULTS: We observed mixed evidence of associations between household …
Symbiotic International Law: Combatting Uyghur Forced Labor, Preston Jordan Lim
Symbiotic International Law: Combatting Uyghur Forced Labor, Preston Jordan Lim
Faculty Publications
Since 2017, the Chinese government has launched a campaign of repression against the Muslim Turkic minorities of Xinjiang, a region located in China’s Northwest. While most scholars have focused on the mass internment of Uyghurs and other minorities, this Article highlights an under-discussed aspect of China’s campaign: the construction of a sophisticated forced labor system. Minority forced labor supplies key sectors of the global economy—from the automotive to the energy sectors—and allows Chinese companies to outcompete foreign firms. The unprecedented scope and sophistication of what I term the “modern Xinjiang forced labor system” imperils the very future of the international …
Source-Specific Nitrate And Nitrite Intake And Association With Colorectal Cancer In The Danish Diet, Cancer And Health Cohort, Dorit W. Erichsen, Nicola P. Bondonno, Pratik R. Pokharel, Susanne M. Rosthoj, Catherine P. Bondonno, Liezhou M. Zhong, Jorg Schullehner, Torben L. Sigsgaard, Peter Fjeldstad Hendriksen, Frederik Dalgaard, Ole Raaschou-Nielsen, Jonathan M. Hodgson, Christina C. Dahm, Anja Olsen, Anne Tjonneland, Cecilie Kyro
Source-Specific Nitrate And Nitrite Intake And Association With Colorectal Cancer In The Danish Diet, Cancer And Health Cohort, Dorit W. Erichsen, Nicola P. Bondonno, Pratik R. Pokharel, Susanne M. Rosthoj, Catherine P. Bondonno, Liezhou M. Zhong, Jorg Schullehner, Torben L. Sigsgaard, Peter Fjeldstad Hendriksen, Frederik Dalgaard, Ole Raaschou-Nielsen, Jonathan M. Hodgson, Christina C. Dahm, Anja Olsen, Anne Tjonneland, Cecilie Kyro
Research outputs 2022 to 2026
Introduction: Nitrate and nitrite, present in food and drinking water, may contribute to colorectal cancer (CRC) through the formation of carcinogenic N-nitroso compounds (NOCs). This study examined source-specific associations with CRC and subtypes, considering potential dietary and lifestyle factors that influence NOC formation. Methods: In the Danish Diet, Cancer, and Health Cohort (N=54,610), nitrate/nitrite intake was estimated from comprehensive databases and national monitoring data. Over 27 years, 2245 CRC cases (1508 colon and 737 rectal) were identified via the Danish Cancer Registry. Cox proportional hazards models adjusted for sociodemographic, diet, and lifestyle factors were used to examine associations, with stratified …
A Library Of Lineage-Specific Driver Lines Connects Developing Neuronal Circuits To Behavior In The Drosophila Ventral Nerve Cord, Jelly H M Soffers, Erin Beck, Daniel J Sytkowski, Marianne E Maughan, Devasri Devarakonda, Yi Zhu, Beth A Wilson, Yu-Chieh David Chen, Ted Erclik, James W Truman, James B Skeath, Haluk Lacin
A Library Of Lineage-Specific Driver Lines Connects Developing Neuronal Circuits To Behavior In The Drosophila Ventral Nerve Cord, Jelly H M Soffers, Erin Beck, Daniel J Sytkowski, Marianne E Maughan, Devasri Devarakonda, Yi Zhu, Beth A Wilson, Yu-Chieh David Chen, Ted Erclik, James W Truman, James B Skeath, Haluk Lacin
2020-Current year OA Pubs
Understanding developmental changes in neuronal lineages is crucial to elucidate how they assemble into functional neural networks. Studies investigating nervous system development in model systems have only focused on select regions of the CNS due to the limited availability of genetic drivers that target specific neuronal lineages throughout development and adult life. This has hindered our understanding of how distinct neuronal lineages interconnect to form neuronal circuits during development. Here, we present a split-GAL4 library composed of genetic driver lines, which we generated via editing the genomic locus of lineage-specific transcription factors and demonstrate that we can use this library …
Re: Comment Letter For Butte Priority Soils Operable Unit (Bpsou) Superfund Operation And Maintenance (O&M) Request For Maintenance – Kelley Stormwater Channels (Dated April 22, 2025), Emma Rott
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Semitic Root Encoding: Tokenization Based On The Templatic Morphology Of Semitic Languages In Nmt, Brendan T. Hatch
Semitic Root Encoding: Tokenization Based On The Templatic Morphology Of Semitic Languages In Nmt, Brendan T. Hatch
Theses and Dissertations
The morphological structure of Semitic languages like Arabic and Hebrew is based on non-concatenative roots and templates. This complex word structure used by humans is obscured to neural models that use traditional tokenization algorithms. In this work, I present and evaluate Semitic Root Encoding (SRE), a tokenization method that represents Semitic words with distinct root and template stem tokens, and apply it to neural machine translation (NMT). I evaluate whether tokenization with the SRE method leads to increases in translation quality, whether it allows NMT models to hypothesize unseen word forms needed at inference, and how impervious resulting NMT models …
How Transitioning Autistic Adults Consciously Perform Neurotypical Communication, Makenna J. Allred
How Transitioning Autistic Adults Consciously Perform Neurotypical Communication, Makenna J. Allred
Theses and Dissertations
Using semi-structured interviews this research explored the experiences of transitioning autistic adults with online communication. Participants shared information about navigating online communication, highlighting specific challenges such as interpreting tone and sarcasm, managing unspoken social norms, like emoji use, and responding to ambiguous or unexpected interactions. Participants shared that misunderstandings do occur in their online communication and how they recognize those miscommunications and strategize around preventing and mitigating them. These findings reveal that while computer-mediated communication offers opportunities for connection, it also presents unique obstacles that can exacerbate feelings of frustration due to miscommunications or misunderstandings. To prevent these social frictions …
Exploring The Feasibility Of Using Virtual Reality With Children With Autism, Gemma Leighton
Exploring The Feasibility Of Using Virtual Reality With Children With Autism, Gemma Leighton
Theses and Dissertations
This study explored the feasibility and social validity of teenagers with autism spectrum disorder (ASD) using a virtual reality (VR) head-mounted display (HMD). VR is emerging as a promising tool for teaching and therapeutic intervention among ASD. Therefore, this study serves to contribute to the field's development by comprehensively evaluating the accessibility for young people with ASD to independently using a VR HMD in a meaningful way. Five teenagers participated (four female, aged 13-15, with mild and mild to moderate support needs) and independently completed tutorials in a virtual environment when learning to operate the VR HMD controllers and hand-tracking …
Impact Of Vein-To-Vein Time In Patients With R/R Lbcl Treated With Axicabtagene Ciloleucel, Frederick L Locke, Armin Ghobadi, Et Al.
Impact Of Vein-To-Vein Time In Patients With R/R Lbcl Treated With Axicabtagene Ciloleucel, Frederick L Locke, Armin Ghobadi, Et Al.
2020-Current year OA Pubs
Chimeric antigen receptor (CAR) T-cell products axicabtagene ciloleucel (axi-cel), tisagenlecleucel (tisa-cel), and lisocabtagene maraleucel (liso-cel) are approved for relapsed/refractory (R/R) large B-cell lymphoma (LBCL). Emerging evidence indicates that delayed CAR T-cell infusion, including prolonged time from leukapheresis to infusion, known as vein-to-vein time (V2Vt), may adversely impact clinical outcomes. We conducted a systematic literature review (SLR) and meta-analysis to identify differences in V2Vt in patients with R/R LBCL treated with axi-cel, tisa-cel, or liso-cel. The impact of V2Vt (< 28 days vs ≥28 to < 40 days vs ≥40 days) on effectiveness and safety outcomes was evaluated in patients treated with axi-cel enrolled in a post-authorization safety study using the Center for International Blood and Marrow Transplant Research data. SLR and meta-analysis showed that patients treated with axi-cel had the shortest median V2Vt (30.6 days) compared with tisa-cel (48.4 days) or liso-cel (35.9 days). Real-world analysis of patients treated with axi-cel demonstrated that V2Vt ≥40 days was associated with significantly lower complete response rate than V2Vt < 28 days (odds ratio [OR], 0.61) or ≥28 to < 40 days (OR, 0.66) and significantly worse overall survival than V2Vt < 28 days (hazard ratio [HR], 1.33) or ≥28 to < 40 days (HR, 1.36). Higher prolonged thrombocytopenia rates were observed in patients with axi-cel V2Vt ≥28 to < 40 days or ≥40 days compared with < 28 days (OR, 1.44 or 1.95, respectively). Together, these results show the impact of V2Vt on patient outcomes with axi-cel therapy and that earlier infusion with CD19-CAR therapies may be beneficial.
High Prevalence Of Co-Infections With Latent Tuberculosis, Syphilis And Hepatitis B And C Among People With Hiv In Ghana: A Call For Integrating Screening Into Routine Care, Helena Lamptey, James Odame Aboagye, Christopher Zaab-Yen Abana, Anthony Twumasi Boateng, Ephraim Mawufemor Kofi Kanda, Dzidzor Aku Attoh, Araba Abaidoo-Myles, Charlotte Borteley Bortey, Jonathan Klutse, Peter Puplampu, Gloria Ansa, Vincent Jessey Ganu, Joseph Oliver-Commey, Evelyn Yayra Bonney, George Boateng Kyei
High Prevalence Of Co-Infections With Latent Tuberculosis, Syphilis And Hepatitis B And C Among People With Hiv In Ghana: A Call For Integrating Screening Into Routine Care, Helena Lamptey, James Odame Aboagye, Christopher Zaab-Yen Abana, Anthony Twumasi Boateng, Ephraim Mawufemor Kofi Kanda, Dzidzor Aku Attoh, Araba Abaidoo-Myles, Charlotte Borteley Bortey, Jonathan Klutse, Peter Puplampu, Gloria Ansa, Vincent Jessey Ganu, Joseph Oliver-Commey, Evelyn Yayra Bonney, George Boateng Kyei
2020-Current year OA Pubs
BACKGROUND: People with HIV (PWH) are at risk of co-infections, such as latent tuberculosis (LTBI), hepatitis B (HBV), hepatitis C (HCV), and syphilis; hence, routine screening is critical. However, evaluation of routine screening is not being fully implemented in Ghana. This study assessed the prevalence of these co-infections among PWH in Accra, Ghana.
METHODS: The HIV Cure Research Infrastructure Study (H-CRIS) followed 390 PWH from three HIV treatment centres in Accra. A cross-sectional study was conducted within this cohort, and participants were screened for LTBI, hepatitis B, hepatitis C, and syphilis using standardized assays. LTBI was detected using the QuantiFERON-TB …
Structure-Function Coupling In The First Month Of Life: Associations With Age And Attention, Ursula A Tooley, Jeanette K Kenley, M Catalina Camacho, Aidan Latham, Dimitrios Alexopoulos, Ashley N Nielsen, Tara A Smyser, Barbara B Warner, Joshua S Shimony, Jeffrey J Neil, Joan L Luby, Deanna M Barch, Cynthia E Rogers, Christopher D Smyser
Structure-Function Coupling In The First Month Of Life: Associations With Age And Attention, Ursula A Tooley, Jeanette K Kenley, M Catalina Camacho, Aidan Latham, Dimitrios Alexopoulos, Ashley N Nielsen, Tara A Smyser, Barbara B Warner, Joshua S Shimony, Jeffrey J Neil, Joan L Luby, Deanna M Barch, Cynthia E Rogers, Christopher D Smyser
2020-Current year OA Pubs
How brain structure relates to function is a critical and open question in neuroscience. Here, we characterize regional variation in structure-function coupling, capturing the degree to which a cortical region's structural connections relate to patterns of coordinated neural activity in healthy, term-born neonates (
Adolescent Preventive Care Outcomes Before And After Covid-19 Onset: What Is The Role Of Telehealth?, Sarah Hayden Knipper
Adolescent Preventive Care Outcomes Before And After Covid-19 Onset: What Is The Role Of Telehealth?, Sarah Hayden Knipper
Dissertations and Theses
Adolescents are a developmentally distinctive population with unique primary health care needs; they comprise about 10% of Oregon's population and more than half are covered by the Oregon Health Plan (OHP). This dissertation investigated significant declines in preventive care utilization (well visits and HPV immunizations) among adolescents enrolled in OHP during the COVID-19 pandemic and the relationship between the decline in utilization and the rise in telehealth availability. The study focused specifically on the role of race/ethnicity, geography, and access to health systems in mitigating or exacerbating decreases in preventive care. A mixed methods approach was employed to understand not …
Middle Meningeal Artery Embolization For Chronic Subdural Hematoma: Meta-Analysis Of Three Randomized Controlled Trials And Review Of Ongoing Trials., Gillespie Cs, M Veremu, Cook Wh, M Ashraf, Lee Ks, Y Chedid, Alam Am, Y Karepov, Davies Bm, E Edlmann, P Papanagiotou, S Korfias, T Santarius, A Kolias
Middle Meningeal Artery Embolization For Chronic Subdural Hematoma: Meta-Analysis Of Three Randomized Controlled Trials And Review Of Ongoing Trials., Gillespie Cs, M Veremu, Cook Wh, M Ashraf, Lee Ks, Y Chedid, Alam Am, Y Karepov, Davies Bm, E Edlmann, P Papanagiotou, S Korfias, T Santarius, A Kolias
Peninsula Medical School
Background: Middle Meningeal Artery Embolization (MMAE) has been proposed as adjunct and stand-alone treatment for Chronic Subdural Hematoma (CSDH). We aimed to meta-analyze three recently published randomized controlled trials, to reliably estimate the effect of MMAE. We also carried out a systematic review of ongoing trials and their key outcomes. Methods: A PRISMA-compliant meta-analysis was conducted (PROSPERO ID CRD42024618816). Three published RCTs (MAGIC-MT, EMBOLISE, and STEM) assessing MMAE in CSDH were included. Trial primary outcomes were pooled for analysis using random effects models. Primary and secondary outcomes (recurrence/surgical rescue, functional outcome) were obtained, stratified by treatment group (undergoing surgery, and …
Method To Improve In-System Performance (Isp), Than Zaw Myint, Kumar Siram, Barish Chakravarty, Xiong Liu, Qiang Bi
Method To Improve In-System Performance (Isp), Than Zaw Myint, Kumar Siram, Barish Chakravarty, Xiong Liu, Qiang Bi
Defensive Publications Series
A storage system enclosure can hold hundreds of hard disk drives (HDDs) and uses high speed cooling fans to control the HDDs’ temperature. The noise and vibration induced by cooling fans will impact HDD performance – IOPS (Input/Output operations Per Second). Currently, foam is added between the HDD’s printed circuit board assembly (PCBA) and basedeck to minimize the impact on HDDs performance. However, the existing foam is smaller, which limits the effectiveness. In this paper, it is proposed to extend the foam to the interface connector area, 1) increasing the effective foam area; 2) adding a constraint to the interface …
The Impact Of Blue Economy Factors On Morocco's Economic Growth, Lqamar Youssef, El Amine Youness Mr, Smouni Rachid Pr
The Impact Of Blue Economy Factors On Morocco's Economic Growth, Lqamar Youssef, El Amine Youness Mr, Smouni Rachid Pr
Journal of Ocean and Coastal Economics
Purpose - This study examines the influence of blue economy factors on Morocco's economic growth.
Design/methodology/ approach - Using secondary data from 1980 to 2022, the analysis focuses on fishery production and its various sectors as contributing factors to economic growth. The study employs the Autoregressive Distributed Lag (ARDL) method and aims to highlight the impact of deep-sea fishing and coastal fishing in the context of a transition to a sustainable and inclusive blue economy.
Findings - The results suggest that coastal fishing has more potential for creating inclusive economic value within the development of the blue economy, thus promoting …