Digital Commons Network^™

Promoting Metacognitive Awareness Through Exploratory Learning., Ryan J. Patrick

Electronic Theses and Dissertations

Exploratory learning engages learners in novel problem solving before direct instruction. This process is designed to lead learners to experience productive failure. Productive failure, however, has been shown to benefit learners by improving the recognition of knowledge gaps, relevant problem features, and deep structures. This allows learners to better attend to relevant information during the subsequent instruction and improves conceptual understanding. This dissertation investigates the role of metacognitive awareness during exploratory learning, in attempt to identify additional metacognitive mechanisms that support exploratory learning. Two experiments tested the theory that exploratory learning promotes metacognitive awareness in exploratory learning. Groups in both …

Effects Of Perfluorooctane Sulfonate In A Mouse Model Of Alcohol-Associated Liver Disease., Paxton Michelle Brizendine/Ames

Electronic Theses and Dissertations

Perfluorooctane sulfonate (PFOS), a pervasive environmental pollutant, has been increasingly associated with the development of metabolic dysfunction-associated steatotic liver disease (MASLD); nonetheless, its connections with alcohol-associated liver disease (ALD) have not been well studied. This study investigates the hypothesis that PFOS exposure alters hepatic metabolism, thereby leading to alterations in ALD severity. Male C57BL/6J mice were fed isocaloric control or 5% ethanol (EtOH) diet for 15 days. From day 6 of feeding, mice were concurrently gavaged with 1 mg/kg PFOS or 2% Tween-80 vehicle for 10 days, followed by a 5 g/kg EtOH binge dose. PFOS and ethanol co-exposure significantly …

Therapeutic Potential Of Sglt2 Inhibitors In A Repeated Love Dose Cisplatin Model., Dianet C. Sanchez

Electronic Theses and Dissertations

Cisplatin is a potent chemotherapeutic, thirty percent of patients develop Acute Kidney Injury (AKI). These patients are ten times more likely to develop chronic kidney disease (CKD). Sodium-glucose-cotransporter-2-inhibitors (SGLT2i), FDA approved for diabetes, has shown protection in multiple mouse models of AKI-CKD. We hypothesize SGLT2i can protect the kidney in a model of repeated low dose cisplatin with/without cancer. B6:129 mice with/without lung adenocarcinoma (Lung-adeno) were treated daily with SGLT2i dapagliflozin (10mg/kg)/vehicle control. After seven days, weekly cisplatin (7mg/kg)/vehicle control was initiated for 3-4 weeks. Following final cisplatin dose, kidney function, injury, fibrosis, inflammation was assessed. SGLT2i treatment attenuated alterations …

Opportunistic Short-Term Water Uptake Dynamics By Subalpine Trees Observed Via In Situ Water Isotope Measurements, Matthias Sprenger, Stefan Seeger, Max Berkelhammer, Nathaniel A. Bogie, Raymond J. Hess, Wendy S. Brown, Sylvain Kuppel, James Knighton

Faculty Research, Scholarly, and Creative Activity

Variations in tree water sources are important to understand in semi-arid ecosystems because climatic shifts towards lower snowpack and increased drought affect water availability in subalpine forests of the western US. Here, we use daily in situ measurements of stable isotopes (²H & ¹⁸O) in soil and tree stem water, soil matric potential and sap flow to study tree water uptake dynamics. We instrumented three soil profiles down to 90 cm, as well as three aspen and engelmann spruce trees near Gothic, Colorado, in the East River watershed. We observed the fate of natural isotopic variations in …

Queer Convergence: Figurative Abstraction In Contemporary Art., Vincent Young

Electronic Theses and Dissertations

This thesis is an exhibition text for the exhibition of the same name held in Schneider Hall Galleries from May 15 to August 21st, 2025. This exhibition explores the work of three contemporary artists – Joshua Jenkins, Drew Scanlon, and Lalana Fedorschak – and analyzes their artwork through the lens of Queer Convergence. Queer Convergence is an exploration of abstracted images of bodies and how we can read these bodies through a queer lens, arguing that the visual language of bodily overlap, melding, and transformation shows the physical form as a site of continual change shaped by shared experience and …

Ecosystem Services Of Urban Green Spaces In Louisville, Ky., Julia Kachanova

Electronic Theses and Dissertations

Accelerating urbanization poses critical challenges to urban green spaces (UGS), vital for ecological balance and human health. Rapid development often results in fragmented habitats, biodiversity loss, and diminished ecosystem service delivery. There is an urgent need to explore and evaluate novel strategies capable of enhancing urban resilience, such as implementing urban orchards, and managing existing parks and gardens in sustainable ways. This dissertation explores how different forms of urban green spaces (UGS) contribute to the provision and maintenance of critical ecosystem services that support human well-being and urban biodiversity. By analyzing UGS impact on ecosystem service provisioning and long-term sustainability, …

Teaching Out Of The Closet: A Qualitative Study To Examine How Queer Educators Navigate Their Professional Work Environments., Brent Braun

Electronic Theses and Dissertations

Queer educators across the nation have faced an onslaught of issues in recent years as they maneuver working in the heteronormative environments of public schools. With the passing of Senate Bill 150 in the Commonwealth of Kentucky in 2023, Kentucky educators became a part of the growing group of educators having to silence themselves within their classroom environments in order to protect their professional careers. This study sought to examine the ways in which queer educators navigate their professional environments in making decisions to either disclose or keep private their identity within the queer community. Semi-structured interviews were completed with …

Intestinal Stromal Cells Play A Critical Role In Protection Mediated By Male Microbiota-Derived Metabolites And Androgens Against Disease In Lupus-Prone Mice., Jing Ma

Electronic Theses and Dissertations

Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving broad immune dysregulation. Despite decades of research, most lupus treatments still have limited effectiveness and can cause serious side effects. Both genetic and environmental factors contribute to lupus susceptibility, and a better understanding of how environmental factors influence disease could guide future therapeutic strategies. SLE shows a strong female predominance. Growing evidence implicates the gut microbiota and sex hormones as key environmental contributors to some autoimmune diseases, including lupus. The gut microbiota can influence host immune function, and interestingly, recent studies have revealed sex-bias in microbiota composition and function. Moreover, …

Linked Lives In The Riverbed: Integrating Fish Host Dynamics, Community Structure, And Demography For Freshwater Mussel Conservation., Jonathan Patrick Frommeyer

Electronic Theses and Dissertations

Freshwater mussels are long-lived benthic invertebrates that play key roles in nutrient cycling, water filtration, and habitat stability in rivers and streams. Despite their ecological importance, they are among the most imperiled faunal groups in North America, with their persistence increasingly threatened by environmental degradation and disruptions to host–parasite dynamics. This dissertation integrates host ecology, community structure, and demographic modeling to assess population viability and guide conservation priorities for mussel species in Kentucky river systems. The first chapter introduces the ecological context and conservation urgency surrounding freshwater mussels. In particular, emphasizing the need for multi-scale approaches to understand how parasitic …

Remotely-Sensed Urbanization And Local Perceptions Of Change From 1985-2024 In Southern Indiana., Marlea Ferber

Electronic Theses and Dissertations

This study is focused on the land cover change of non-built land cover being transformed into built land cover in two counties in Southern Indiana using mixed methods. Remote sensing was used to identify and quantify land cover change, and interviews were used to understand local perceptions of the physical land cover changes. The study area is situated along the rural-urban continuum with Louisville, Kentucky across the Ohio River. It is important to quantify the amount of land change conversion to built settlement as patterns and rate of urbanization help us to better manage transitions along the rural-urban continuum, but …

An Exploration Of Lgbtq+ Runner Motivation And Constraints., Michael Clemons

Electronic Theses and Dissertations

Running offers extensive benefits beyond physical fitness, encompassing mental, emotional, and social advantages. However, LGBTQ+ individuals face unique challenges in participating in the running community, which remains predominantly White, cisgender, and heterosexual. With the LGBTQ+ population in the U.S. growing, there is a need to understand their motivations and barriers to participation in running events and training groups. This study explores these motivations using self-determination theory, comparing LGBTQ+ and non-LGBTQ+ runners to identify differences in driving factors such as social connectivity, self-esteem, and competition. Additionally, it examines barriers LGBTQ+ runners face, ranging from structural obstacles to intrapersonal challenges, and how …

Predictor-Informed Bayesian Nonparametric Clustering., Md Yasin Ali Parh

Electronic Theses and Dissertations

In this dissertation, we performed clustering of observations such that the cluster membership is influenced by a set of predictors. To that end, we employ the Bayesian nonparametric Common Atom Model (CAM), which is a nested clustering algorithm that utilizes a (fixed) group membership for each observation to encourage more similar clustering of members of the same group. CAM operates by assuming each group has its own vector of cluster probabilities, which are themselves clustered to allow similar clustering for some groups. We extend this approach by treating the group membership as an unknown latent variable determined as a flexible …

Optimization And Simulation Models For Integrating Social Determinants In Assessing And Optimizing The Accessibility And Efficiency Of Community Pharmacy Networks., Md Morshedul Alam

Electronic Theses and Dissertations

Community pharmacies are essential components of the healthcare system, serving not only as points of medication access but also as providers of health consultations and preventive care. However, disparities in pharmacy access persist due to a combination of geographic, socioeconomic, and behavioral factors. This dissertation develops a comprehensive methodological framework to evaluate and improve accessibility to community pharmacies, integrating optimization, choice modeling, and discrete event simulation. First, we develop an Optimal Community-Pharmacy Assignment (OCPA) model to quantify geographic accessibility across a regional population network. The model minimizes risk-adjusted travel distances between population centers and pharmacies, incorporating social determinants of health …

Synthetic And Pharmacological Diversity Of Nitrogen-Containing Heterocycles., Shramana Ghosh

Electronic Theses and Dissertations

Nitrogen-containing heterocycles are a foundational class of compounds in organic chemistry, playing critical roles in pharmaceuticals, agrochemicals, and natural products due to their structural diversity and biological relevance. Among them, isoindolinones are notable for their wide range of pharmacological activities. Structurally, isoindolinones possess a benzylic methylene group adjacent to the nitrogen atom, which allows for selective oxidative transformations to yield phthalimide derivatives, well-known intermediates in synthetic, pharmaceutical, and materials chemistry. Although phthalimide is traditionally employed as a protecting group for amines via the Gabriel synthesis, isoindolinone offers a valuable alternative. Through a modified Gabriel-like approach, isoindolinones can serve as more …

Trauma Network Design Considering Patient Safety And Cost., Lin Lin

Electronic Theses and Dissertations

Trauma, as the leading cause of mortality and morbidity for those under the age of 45 in the US, incurs trillions in annual economic costs. The time-sensitive nature of trauma treatment necessitates an effective, coordinated regional trauma system to optimize patient safety. However, the financial burden associated with trauma care, especially due to low-insured population, presents a significant challenge to the financial health of trauma centers (TCs). To address critical challenges in this domain and provide much-needed insights to trauma decision-makers regarding their trauma system cost, network design, and subsidy policy, this dissertation proposes 3 contributions. First, we introduce an …

The Substance Of Reality: Moral Perfectionism In Shakespeare's Hamlet., David Wright

Electronic Theses and Dissertations

Through a selection of and close reading of key passages, I offer an interpretation of Hamlet that seeks to illuminate the play as an important work of moral philosophy, and to situate the play within a strand of moral philosophy named moral perfectionism by Stanley Cavell. Indeed, Hamlet is a masterpiece of Renaissance drama, but when read with attention to moral perfectionism, the play yields additional layers of meaning. Hamlet is a “philosophical drama” that navigates the “moral calling of philosophy”—a text that seems to, almost uncannily, elicit the audience to think reflectively, to ask fundamental human questions along …

Genes That Matter: Survival Modeling In Tcga-Brca With Treatment Interactions., David Pratt

Electronic Theses and Dissertations

High-dimensional genomic data offer both promise and challenges for identifying clinically relevant biomarkers. This study developed a parallelized survival modeling pipeline to identify genes associated with overall survival in breast cancer, with a focus on gene-by-treatment interactions and patient heterogeneity. RNA-Seq data from female patients in the TCGA-BRCA cohort were analyzed. Univariate Cox proportional hazards models were used to screen genes, adjusting for age, race/ethnicity, treatment status, and cancer stage. A LASSO-penalized Cox regression was fit across 2000 random seeds to assess feature stability. Genes were filtered by expression level, statistical significance, and hazard ratios (effect sizes) in either direction, …

Bleeding Out From The Redlining: An Autoethnographic Study Of Racial Equity Policy Enactment In A Large, Urban School District., Anderson Aven Cook

Electronic Theses and Dissertations

This autoethnographic study investigates the enactment and impact of racial equity policies within Jefferson County Public Schools (JCPS), a large urban school district in Louisville, Kentucky. The research is motivated by the ongoing challenges of achieving true educational equity for Black and Brown students, a struggle rooted in historical injustices such as redlining. Despite over seven years of policy implementation aimed at promoting racial equity, academic and behavioral disparities between Black and Brown students and their White counterparts have shown little improvement. Utilizing a qualitative methodology, this study employs autoethnography to intertwine personal narrative with scholarly analysis, exploring the lived …

Polymathy: The Foundational Source Of Creativity And Innovation., Michael Araki

Electronic Theses and Dissertations

In an era of mounting complexity and a growing need to transcend siloed thinking, this dissertation advances polymathy as a critical yet underexplored construct in the management and behavioral sciences. Polymathy is framed as an expansive approach to the pursuit, development, and application of knowledge, marked by the conjunction of breadth, depth, and integration. Building on a thought lineage that stretches from Ancient Greece through the Renaissance to the present day, this work shows that polymathy is neither a relic of the past nor an achievement reserved for a few—but a mode of being, thinking, and acting in the world …

Evaluating Maternal Polar Bear Denning Habitat Along The Arctic Coastal Plain And Assessing The Potential For Noise Disturbance In Polar Bear Dens, Ethan Ducharme

All Graduate Theses and Dissertations, Fall 2023 to Present

Polar bears (Ursus Maritimus) in northern Alaska are increasingly choosing land instead of sea ice to build their maternity dens. As sea ice continues to decline due to climate change, this shift makes it more important than ever to identify and protect the areas where polar bears dig dens to give birth and raise their cubs. In the first part of my research, I used new satellite-based elevation data to map potential polar bear denning habitat across a large section of Alaska’s Arctic Coastal Plain. This technology allowed me to identify the types of sloped terrain where drifting …

Operationalizing Camera-Based Hydrologic Monitoring With Ai And Edge Computing: Towards Real-Time Water Level And Discharge Measurements, Razin Bin Issa

All Graduate Theses and Dissertations, Fall 2023 to Present

Monitoring river water levels and flows is critical for managing water supplies, protecting against floods, supporting ecosystems, and informing infrastructure planning. However, traditional methods rely on sensors installed directly in rivers, which can be expensive, difficult to maintain, and vulnerable to damage—particularly in remote or hazardous locations. In many regions, limited budgets and access challenges result in large gaps in river monitoring networks.

This research explores an innovative alternative: using fixed cameras and artificial intelligence (AI) to monitor rivers from a distance. The approach allows for non-contact observation of water levels and flows by analyzing images captured by cameras installed …

Migration As Adaptation: Place-Based Vulnerability Near The Drying Great Salt Lake, Dallin Johnson

All Graduate Theses and Dissertations, Fall 2023 to Present

The drying of the Great Salt Lake presents a complex and evolving threat to Utah residents, with wide-ranging environmental, economic, and health implications. This study explores the individual and structural factors impacting Utahns' ability to utilize migration as a form of adaptive capacity in response to these threats, using mobility justice and cumulative advantage and disadvantage theory as guiding frameworks. Drawing on survey data, a multilevel logistic regression model identifies key structural factors, including age, income, and gender, that influence perceived migration ability. Additionally, a 2x2 typology categorizes distinct profiles of vulnerability to the Great Salt Lake based on different …

Water Conservation Strategies For Growing Ornamental Plants In Utah Landscapes, Jenny L. Koller

All Graduate Theses and Dissertations, Fall 2023 to Present

When early pioneers settled in Utah, they faced challenges living in a dry region with limited water. They built dams, canals, and irrigation systems by working together as a community to manage their water needs. However, adoption of European landscaping methods, farming and rapidly growing population increased water need while climate change and frequent drought reduced water supply.

Today, Utah is one of the driest states and uses more water per person than most other states in the nation. If things don't change, the state could run out of water by 2060. To address Utah's growing water challenges, this research …

Factors Influencing Cognitive Load: Exploring Affective Elements, Motivational Constructs, And Regulatory Strategies In Learning, Rebecca B. Brockbank

All Graduate Theses and Dissertations, Fall 2023 to Present

There are three separate research papers within this dissertation, each looking at specific elements of learning. The process of learning is a complex phenomenon that includes not just cognitive aspects, but also emotional and motivational aspects. During learning there is an input of information into our cognitive system (i.e., minds). When too much information is given or the information is not presented effectively, this can overload our cognitive system and negatively impact our learning. Understanding how to learn within the parameters of our cognitive system is important. However, learning is more complex than just the simple input and output of …

Watermelon Production In Utah: Exploring Biostimulants To Reduce Water And Fertilizer Use, Evan A. Christensen

All Graduate Theses and Dissertations, Fall 2023 to Present

The impacts of climate change and drought threaten water supplies that are important for watermelon production. Additionally, rising fertilizer costs and off-site effects from improper fertilizer applications cause concerns for the sustainability of watermelon production. Biostimulant products have shown promise in helping plants maintain production under reduced irrigation conditions and may offset fertilizer addition. Biostimulants are any microorganism or substance that is applied to a plant with the goal to increase nutrition efficiency, crop quality traits, or tolerance to environmental stresses. Most of the production in the U.S. uses seedless watermelon which are typically grown in greenhouses and transplanted due …

Cognitive Behavioral Therapy Complemented With Emotion Regulation Training For Patients With Somatic Symptom Disorder: 3-Year Follow-Up To A Randomized Controlled Trial, John Barr

All Graduate Theses and Dissertations, Fall 2023 to Present

This manuscript is a 3-year follow-up analysis of a multicenter, randomized, parallel group, controlled trial (N = 254) employed with individuals struggling with somatic symptom disorder (SSD; Kleinstäuber et al., 2019) comparing the effects of cognitive behavioral therapy (CBT) alone and enriching cognitive behavioral therapy with emotion regulation training (ENCERT). Results from Kleinstäuber et al. (2019) suggested that both of these interventions were similarly efficacious for SSD for symptom severity (primary outcome), with moderate to large effects at post treatment and 6-month follow-up. Further analysis of secondary outcomes and moderation effects demonstrated results suggesting ENCERT was superior to CBT-SOMA …

Out Of Core And Adaptive Image Blending Approach For Large Scale Image Mosaics, Marcus Quincy

All Graduate Theses and Dissertations, Fall 2023 to Present

When creating large stitched images, like those used in maps made from aerial photos, it’s important to make sure the seams between individual pictures aren’t visible. This process, known as color blending, helps smooth out differences in lighting or weather across the images. But blending very large images, such as those made from many high-resolution aerial photos, can require huge amounts of memory, making it hard to do on a typical computer.

In this work, we developed a method that breaks the problem into smaller pieces, so only a small part of the image needs to be worked on at …

A Value Sensitive Design Approach To Reimagining Parental Control Apps, Prakriti Dumaru

All Graduate Theses and Dissertations, Fall 2023 to Present

Parental control apps are often used by families to regulate children's device usage and keep them safe online. However, existing tools focus on monitoring and restricting children, which can lead to tension and mistrust within families. This research takes a new approach by exploring how parental control apps can be redesigned to support positive family values, like encouraging open communication between parents and children and helping children self-regulate their behaviors. Through four in-depth studies, this dissertation looks at how these values play out in different real-life situations. It includes families with children on the autism spectrum, divorced households where parents …

Usm Student Guide To Ai And Learning, University Of Southern Maine's Ai Task Force

Faculty and Staff Scholarship

Access to technologies that use artificial intelligence (AI) has expanded greatly. As with any technology, there are pros and cons for using AI in any aspect of our lives. This guide offers a set of considerations for if, how, and when to use AI as a USM student.

Redressing The Harm Of Accelerated Approval, Laura Karas

Articles

The accelerated approval pathway of the United States Food and Drug Administration (FDA) enables drugs to come to market more quickly than would be possible under a traditional FDA approval pathway. Accelerated approval is based upon the agency's determination that changes in a surrogate or intermediate clinical endpoint are "reasonably likely" to predict a clinical benefit meaningful for patients. In essence, the pathway affords sick patients earlier access to potentially beneficial drugs while trials to confirm clinical benefit continue. Accelerated approval has been likened to a social compromise in which promising drugs enter the market sooner in exchange for a …