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Effects Of Sex And Aging In The Response To Global Cerebral Hypoperfusion, Alexis Mcalister

Dissertations and Theses (Open Access)

Introduction

The prevalence of dementia worldwide is projected to double by the year 2030 and triple by 2050. Vascular cognitive impairment and dementia (VCID) encompasses diseases that lead to cognitive decline and dementia due to cerebrovascular disease. VCID is the second most common form of dementia after Alzheimer’s disease, accounting for approximately 15- 40% of all dementia cases. Reductions in cerebral blood flow from intracranial and extracranial atherosclerosis increase VCID risk, even in the absence of overt clinical or imaging evidence of stroke/embolization. The pathology seen in patients with chronic cerebral hypoperfusion, such as inflammation, neuronal loss, white matter abnormalities, …

Microbial Metabolite Regulation Of Microglial Ahr Signaling In Alzheimer’S Disease, Ghalya E. Alrousan

Dissertations and Theses (Open Access)

Introduction: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β plaque accumulation, neuroinflammation, and cognitive decline. Recent evidence suggests that systemic factors, particularly the gut microbiota and its metabolites, play a significant role in shaping brain immune responses, including microglial activation. However, the mechanisms linking gut dysbiosis to microglial dysfunction in AD are poorly understood. The aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor responsive to tryptophan metabolites, has recently gained attention as a key regulator of neuroinflammation and microglial function. I hypothesize that the loss of beneficial microbial AHR ligands, specifically indole derivatives, during aging and AD …

Autoantibody Profiling To Predict Response To The Anti-Pd-1 Therapy, Pembrolizumab, In Rare Tumors, M H Derbala, J Hajjar, B Stephen, S A Gurses, E Kwiatkowski, P Budde, H-D Zucht, M Bräutigam, A-S Lindemann, B A Abhari, M A Gouda, L Castillo, A Zarifa, J A How, E Rodriguez, J T Moyers, D S Hong, S Fu, F Meric-Bernstam, A Naing

Faculty, Staff and Student Publications

Background: Immune checkpoint inhibitors (ICIs) have limited response rates in selected patients and can cause potentially life-threatening immune-related adverse events (irAEs). This underscores the urgent need for the development of biomarkers predictive of ICI response. Pre-existing autoantibodies (AAbs) have been linked with responses to ICIs and the development of irAEs. We conducted AAb profiling to assess associations between baseline AAbs and clinical benefit (CB) in patients with rare tumors treated with anti-programmed cell death protein 1-based therapy.

Patients and methods: We conducted AAb profiling using Oncimmune's SeroTag multiplex antibody discovery technology and immune oncology array containing 1168 antigens. The study …

Racial Disparities In The Receipt Of Therapies For Cancer, Hypertension, And Diabetes, And In Mortality In A Large Population-Based Cohort Of Older Men With Prostate Cancer, Zhuoyun Li, Xianglin L Du

Faculty, Staff and Student Publications

Background: Racial disparities in treatment and mortality were widely studied among prostate cancer patients; however, few studies considered the prevalence of hypertension and diabetes and their treatment status.

Objectives: To determine whether there are racial discrepancies in the use of anti-cancer, antihypertensive, and antidiabetic drugs in a cohort of long-term survivors of prostate cancer diagnosed in 2007-2015; and to examine racial disparities in mortality after adjustments for their differences in those treatments.

Methods: We used the SEER (Surveillance, Epidemiology, and End Results)-Medicare linked database and included records for patients with prostate cancer at age 65 years or older diagnosed from …

The Effects Of A Tier 2 Intervention On The Behavior Of Elementary School Students Participating In Second Step: Enhancing A Schoolwide Social-Emotional Learning Curriculum, Charlotte Annalee Kennington

Theses and Dissertations

After reviewing the current research literature on the effects of social-emotional learning (SEL) on the behavior of elementary-age children, it was clear that there was limited research data on the effects of Tier 2 interventions designed to augment the effects of schoolwide SEL programs. Specifically, to what extent could a brief, group-delivered intervention improve the academic engagement, problem behavior, and socially appropriate comments of fifth-grade students receiving schoolwide SEL through Second Step in a traditional public school? Three fifth-grade students were recruited to participate in this study who all engaged in frequent problem behavior during Second Step lessons and throughout …

Executive Committee - Agenda, 08/01/2025, Academic Senate

Academic Senate Agendas

No abstract provided.

The Experiences Of Elite, Female Club Volleyball Players – An Interpretative Phenomenological Analysis, Chelsea Brehm

Dissertations

The purpose of this qualitative study was to investigate the lived experiences of female athletes participating in national-level club volleyball in a Midwestern U.S. state. Amid increasing sport privatization and a growing emphasis on early sport specialization, female athletes in club volleyball are navigating complex pressures tied to elite competition, college recruitment, and psychosocial well-being. Using Interpretative Phenomenological Analysis (IPA), this study sought to uncover how athletes experience and make meaning of their participation in this highly demanding sport structure.

Data collection included a demographic survey distributed to national-level athletes (n = 66) and in-depth, semistructured interviews with five female …

Chancery Court Applies Entire Fairness Standard Of Review In Assessing Actions Of Conflicted Fiduciaries Engaging In "Value-Destructive" Spac Transactions, Robert S. Reder, John Rand Dorney

Vanderbilt Law School Faculty Publications

In the Gig Cases, Vice Chancellor Will followed the line of analysis she first adopted in MultiPlan by applying traditional fiduciary principles to address conflicts inherent in the standard SPAC structure. First, the Vice Chancellor rejected application of the deferential business judgment rule in favor of the more exacting entire fairness standard, finding both a conflicted controller and a conflicted board. While maybe not outcome determinative, this standard of review places a heavy burden on fiduciary defendants that generally precludes pleading stage dismissal. Second, the Vice Chancellor closely parsed language in disclosures made to stockholders to support, at least at …

Drug Delivery, Disulfide Crosslinked Hydrogel Coating For Polydimethylsiloxane (Pdms) Implant Materials, Paul A. Contos, Paul Anthony Contos

Master's Theses

Though polydimethylsiloxane (PDMS) is often used in medical devices due to its desirable mechanical properties and biocompatibility, its surface is often prone to bacterial adhesion. This is especially a problem for catheters, where bacteria can adhere and form biofilms that can in turn result in Urinary Tract Infections (UTI). In order to deter the presence of UTI causing bacteria on PDMS catheters, methods were developed to formulate a disulfide crosslinked hydrogel coating and create a methodology to allow adhesion to a PDMS substrate. The hydrogel coating discussed in this paper will be synthesized by chemically crosslinking stimuli-responsive vesicles, that carry …

Internal Funding Newsletter, Academic Year 2024-2025, Office Of Research And Creative Activity, University Of Nebraska At Omaha

Internal Funding Newsletters

The University of Nebraska at Omaha is committed to educating people of the world and the Office of Research and Creative Activity is proud to contribute to UNO?s exceptional education, groundbreaking research, and the life-long success of students and alumni. UNO innovates for the public good through pragmatic and impactful research and discovery. This year's programs provided over $750,000 in awards for students and faculty. These projects included recording a new album of music for a saxophone, flute, and piano trio, understanding college campus bicycle theft, studying student perceptions of the difficulty of organic chemistry concepts, evaluating a therapy program …

Burning The Wick At Both Ends: A Three Paper Investigation Of Burnout And Educators, Karla P. Miner

All Dissertations

Researchers in the late 20th century identified the impact of burnout on organizational and individual success. The urgency to address burnout in education has intensified following the disruptions caused by the COVID-19 pandemic. Teacher burnout, characterized by exhaustion, cynicism, and feelings of inadequacy, has been a commonly discussed topic among educators internationally following the COVID-19 pandemic. Recent studies highlight the alarming rates of burnout among educators, emphasizing the need for targeted interventions to support well-being and mitigate educator attrition. This collection of papers addresses three primary aspects of burnout and practice: a literature review of individual and organizational practice, a …

Revolutionizing Digital Privacy Education For Older Adults: Enhanced Interventions And Ai-Assisted Learning Strategies, Heba Aly

All Dissertations

As older adults increasingly engage with digital platforms, they face unique privacy risks stemming from limited digital literacy, reduced trust in AI technologies, and constrained access—especially in rural or underserved communities. While digital tools offer benefits like social connection and information access, current privacy education efforts often neglect the needs of older adults. This dissertation addresses this gap by developing, testing, and refining digital privacy education interventions tailored for older adults, with a focus on trust, personalization, and AI-assisted learning.

Study 1 evaluates multiple instructional modalities across age groups, revealing older adults prefer structured videos and interactive tutorials, while younger …

A Study On The Propagation And Exploitation Of Structured Light In Underwater Turbulence, Jaxon P. Wiley

All Dissertations

The development and optimization of optical systems will play a pivotal role in the continued exploration and exploitation of the world’s underwater environments. These systems offer advantages in many sectors, and includes applications in areas such as high-speed communication, advanced sensing and imaging, and environmental characterization and monitoring. Underwater environments offer a plethora of challenges, however, and mitigating these obstacles remains an arduous task. In this work, the inherent advantages of structured light are leveraged to optimize optical system performance through non-ideal underwater conditions. Additionally, fundamental relationships between the generation of specified structured modes and their interactions with complex environments …

Multiple View Neural Regression Of A Facial Shape Model, Xiang Li

All Dissertations

Creating re-topologized 3D facial meshes is a critical step in high-quality facial animation pipelines, yet it remains a labor-intensive and time-consuming task. Traditional approaches typically rely on multiview stereo reconstruction and specialized photometric environments to acquire accurate geometric and reflectance data under controlled conditions. This dissertation presents work toward more efficient capture of production-ready meshes including (1) developmental aspects of VarIS, a custom-designed light sphere capable of capturing high-resolution stereo geometry and reflectance maps—including diffuse, specular, and normal components under programmable illumination; (2) a study of the effects of camera parameters on automatic 2D and 3D landmarking methods, (3) methods …

Strategic Implications Of Responses To Security And Privacy Challenges, Shivan Bhatt

All Dissertations

This dissertation investigates strategic implications of information security and privacy for organizations and society in the contexts of ransomware and mobile apps. The first study examines how organizations’ disclosures of responses to ransomware attacks affect ransomware strain survival. Ransomware attacks force organizations to make consequential decisions regarding disclosure—whether to reveal ransom payments, negotiation attempts, or coordination with external stakeholders. This study investigates how these disclosure choices influence the survival of ransomware strains. Drawing on disclosure theory and institutional theory, we theorize that disclosure behavior is shaped by dual logics and audiences: strategic signaling towards attackers and institutional conformity aimed at …

Designing Multilingual (Maker) Spaces: Exploring The Intersections Of Play, Posthumanism, And Pre-Kindergarten, Victoria G. Pennington

All Dissertations

In this dissertation, I explore the posthuman play literacies of multilingual makerspaces with four-year-olds, emphasizing the need for such a study while situating my arguments within the existing literature and outlining my methodological approach. Chapter One critiques the public 4-year-old kindergarten systems, arguing institutionalized cultural and linguistic ideologies restrict multilingual learners’ (MLs) opportunities for meaning-making. I draw on the raciolinguistic perspective (Flores & Rosa, 2015) and its intersection with a posthumanist paradigm (Braidotti, 2013), framing my research questions as lines of inquiry to guide the study. Key posthumanist literacies concepts are defined, highlighting the entanglement of literacies, discourses, materials, and …

Engaging Minds: Assessing The Impact Of Arts-Integration On Science Achievement And Engagement Using Planned Experimentation, Fonda G. Dupre

All Dissertations

Elementary science education is essential for fostering inquiry, critical thinking, and problem-solving, yet it is often reduced or deprioritized due to the pressures of high-stakes testing in reading and mathematics. Despite federal calls for a well-rounded education under the Every Student Succeeds Act (2015), instructional time for science remains limited in many schools, particularly in under-resourced and high-poverty contexts. This reduction of science instruction time exacerbates achievement gaps and limits student engagement and interest in STEM fields.

This planned experiment investigates whether Arts-Integrated science instruction can increase student engagement and improve academic achievement among fourth-grade students at Foothills Academy of …

Advancing Life Cycle Assessment For Environmental Sustainability Of Carbon Fiber-Reinforced Polymer Composites (Cfrps)), Hao Chen

All Dissertations

Carbon fiber-reinforced polymer composites (CFRPs) have emerged as promising materials, particularly for lightweight applications, with the potential to reduce environmental impacts across multiple sectors, including automotive, aerospace, and renewable energy. However, fully realizing their sustainability potential requires a more comprehensive and context-specific understanding of their environmental performance throughout the entire life cycle—from raw material production to end-of-life management.

This dissertation advances life cycle assessment (LCA) practices for CFRPs by addressing key challenges across multiple phases of the CFRP life cycle. First, I conducted a critical review and meta-analysis of carbon fiber manufacturing, revealing substantial variability in reported data on energy …

Influence Of Experience And Risk With Natural Hazards On Geoscience Interest And Career Expectations, Shannon Conner

All Dissertations

Understanding student interest in geoscience is important, as it has the potential to inform departmental decisions such as the selection of classroom examples and marketing strategies to attract new geoscience majors. Recruitment to geoscience is critical to address future social and environmental challenges. Our work may also provide insight into how to approach persistent recruitment problems within departments, such as student enrollment and the lack of diversity within the geosciences. This work involves developing a geoscience interest scale, integrating geospatial and educational data sets related to hazard risk and interest, and an exploring career motivations as related to natural hazard …

Effects Of Lossy Compression Data On Machine Learning Models, Max H. Faykus Iii

All Dissertations

Machine learning is a fundamental tool that is incorporated in every field across academia and other industries. Due to the large amount of data needed for training machine learning models, lossy compression plays a crucial role in storing data. Machine learning involves the use of algorithms and models to learn patterns in data. This allows the AI to make decisions without specific programming. On the other hand, compression utilizes encoding and decoding techniques to reduce the size of files. Compression is either lossy or lossless, lossy causes a loss of data while lossless preserves the data. This dissertation will explore …

More Than Numbers: Interrogating The Instructional Capacity Of Middle School Mathematics Teachers, Yashica R. Latimer

All Dissertations

This study examines how middle school mathematics teachers conceptualize and enact culturally responsive mathematics teaching (CRMT) within a district-supported professional learning initiative. Guided by the CRMT framework developed by Aguirre and Zavala (2013), the research explores how instructional decision-making intersects with equity-focused pedagogy.

Two central questions inform the study: (1) How do middle school mathematics teachers interpret and apply CRMT principles in their classroom practice? (2) What specific instructional strategies do teachers use to integrate cultural responsiveness into their instruction?

Using a qualitative multiple-case study design, data were collected from three teachers participating in a professional learning group called MORE …

From Pencil To Pixel: How Leadership Shapes Organizational Responses To Competence-Destroying Technological Change, Jennifer Underwood

All Dissertations

This dissertation examines how managerial leadership enables organizations to overcome inertia during competence-destroying technological change through a historical comparative case analysis of the animation industry's transition from hand-drawn to computer-generated imagery (CGI) between 1980-2000. Drawing on archival data from Disney, Pixar, and Don Bluth Studios, I identify three distinct leadership approaches—pioneering, bridging, and preserving—that differently influenced how workforces adjusted their views of identity, process, and change. These adjustments led to three different outcomes: transformative integration, constrained adoption, and entrenched resistance. This research makes three theoretical contributions and develops a novel framework that explains how leadership can constrain or enable transformation, …

Exploring The Effects Of Remote Work On Leadership Pipelines: With A Focus On Professional Women And Minorities, Mark S. Andrekovich

All Dissertations

I analyzed data from five U.S.-based companies to understand how remote work models affect leadership advancement. Using Role Congruity, Status Characteristics, and Intersectionality theories, I analyzed five hypotheses about the impact of remote work on leadership pipelines. Two of the five hypotheses were supported, revealing bias patterns rather than issues related to remote work. For instance, white employees had greater access to remote work opportunities than non-white employees, who had fewer promotions despite similar performance scores. Contrary to expectations, I found that remote work does not inherently affect promotional advancements. Via a post hoc analysis, I found that hybrid professionals …

Increasing Student Enrollment In The Dual-Language Mandarin Immersion Program: Leveraging Marketing And Outreach Within A Strategic Enrollment Management Framework, Na Zhang

All Dissertations

This study examines the impact of marketing and outreach strategies on enhancing family awareness and increasing enrollment in a Dual-Language Mandarin Immersion (DLMI) program in South Carolina. The history of bilingual education has shown an increased interest in recent decades. At the same time, Mandarin immersion programs continue to face challenges and under-enrollment. This study employs a mixed-methods design to collect data from surveys and interviews with parents of children entering kindergarten. The data collection also includes interviews with Mandarin Immersion teachers and attending community events. The purpose is to identify effective practices and ongoing barriers to enrollment. Informed by …

Transforming Childhood Adversity Into Executive Excellence: Impact On Firm Performance, Kimberly Byars

All Dissertations

Many successful business leaders have overcome difficult childhoods, yet little research has examined how early hardships might actually contribute to leadership effectiveness. This study investigated whether CEOs who experienced childhood adversity can transform these difficult experiences into strengths that improve their companies' performance.

The research surveyed 165 business owners across two groups: general business owners and automotive dealership owners. Participants answered questions about their childhood experiences, their ability to grow from trauma, and various psychological traits like grit, mental toughness, resilience, and growth mindset. Company performance data was also collected.

The findings challenge conventional wisdom that difficult childhoods necessarily harm …

Organizational Metamorphosis: When Artificial Intelligence Transforms Companies Into New Economic Life Forms, Allan M. Glass

All Dissertations

Traditional theories of organizational change fall short in explaining how artificial intelligence (AI) transforms organizations. This grounded theory study, based on interviews with 34 organizational leaders, identifies a novel phenomenon: organizational metamorphosis - the irreversible transformation of organizations into fundamentally new entities through deep integration with AI as a cognitive partner.

The metamorphosis process unfolds in three phases. Individual Awakening occurs when leaders experience powerful interactions with AI, prompting a rapid shift from skepticism to advocacy. Once a critical mass of leaders undergo this shift, it initiates Organizational Restructuring, characterized by reimagined work design, boundary dissolution, and altered temporal rhythms. …

Evaluating The Impact Of Medicaid Expansion On Non-Small Cell Lung Cancer Care And Health Disparities, Marvin Idoteyin Okon

All Dissertations

Persistent disparities in non-small cell lung cancer (NSCLC) outcomes reflect broader structural inequities shaped by race, place, and socioeconomic conditions. This dissertation examined trends in NSCLC outcomes over the past two decades and evaluated the impact of Medicaid Expansion (ME) under the Affordable Care Act on improving outcomes and reducing disparities, especially in marginalized communities.

Using nationally representative datasets, three interrelated studies were conducted. The first assessed trends in NSCLC incidence, early-stage diagnosis, and 3-year survival from 2002-2021, stratified by metropolitan status, deprivation (Social Deprivation Index), and segregation (Index of Concentration at the Extremes). While incidence declined and early-stage diagnosis …

Melts To Solutions: Structure, Dynamics, And Response Of Polyelectrolytes, Shalika Meedin

All Dissertations

The current research elucidates the changes in the structure and motion of polyelectrolytes as they are perturbed by solvents and shear flows. Polyelectrolytes are macromolecules whose backbone consists of long, predominantly hydrocarbon chains, substituted by ionizable groups, which tend to dissociate into ions in polar solvents. Their properties result from a delicate balance of elastic energy that arises from the polymeric backbone and electrostatic forces, which stem from the ionizable groups. Though polyelectrolytes have an immense potential to propel numerous technologies, from clean energy to drug delivery systems, understanding the delicate balance between the properties of the polymer backbone and …

Bringing To Life Our Mission And Vision: The Role Of Professional Development In Instructional Technology, Katherine I. Britton

All Dissertations

Despite improved access to digital tools and increased demand to prepare students for the 21st-century workforce, K-12 educators still have difficulty balancing technology, pedagogy, and content in the classroom. In the rural school district of Pleasant County, there is variation in the utilization of instructional technology to engage students as content creators, collaborators, critical thinkers, and communicators. This problem was substantiated as evidenced by the study of the Effective Learning Observation Tool, which identified the domain of engaging, learning-centered instruction as an area of opportunity for the district, with the lowest score in digital learning (Cognia, 2023). In this study, …

Accurate Temporal Integration Schemes For Nonlinear Adsorption Problems, Evan D. Butterworth

All Dissertations

We consider a nonlinear transport problem to model the chromatography process of high-capacity multimodal membranes. Robust and efficient algorithms that simulate these bioseparation processes are critical to developing therapeutics for various chronic illnesses and infectious diseases. However, much of the current methodology focuses on stabilization and linearization techniques, often implementing low-order time-discretizations and linearized adsorption, resulting in inefficiencies and inaccuracies in the numerical solution. Utilizing Rothe's method, we develop various time-discretization schemes coupled with the finite element method to solve the fully implicit problems. Stability and solvability results are presented for several methods. Through multiple high-level software implementations paired with …