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Enhancing The Value Of Satellite Earth Observations For Coastal Management: Tools For Collaboration And Co-Development, Nicole Dejeet Bartlett Aug 2025

Enhancing The Value Of Satellite Earth Observations For Coastal Management: Tools For Collaboration And Co-Development, Nicole Dejeet Bartlett

Graduate Doctoral Dissertations

Despite unprecedented satellite Earth observation (EO) capabilities and free data availability, widespread adoption in coastal management remains limited due to persistent communication barriers between satellite experts and coastal practitioners. This dissertation addresses the fundamental challenge of translating satellite EO technical capabilities into management-relevant applications. Through synthesis of literature, stakeholder interviews, and two multi-year co-development case studies in Virginia's Middle Peninsula and Cape Cod, Massachusetts, this research identifies systematic barriers to satellite EO adoption and develops innovative frameworks for overcoming them.

The work argues for a common language between satellite product developers and coastal managers, identifying communication barriers spanning technical, institutional, …


Quantum Dot Light Emitting Diodes As A Light Source For Photodynamic Therapy, Hamid El Hamidi Aug 2025

Quantum Dot Light Emitting Diodes As A Light Source For Photodynamic Therapy, Hamid El Hamidi

Graduate Doctoral Dissertations

ABSTRACT:

QUANTUM DOT LIGHT EMITTING DIODES AS A LIGHT SOURCE FOR PHOTODYNAMIC THERAPY

Photodynamic therapy is a cancer treatment modality that involves the accumulation of a photosensitizer, exposure to visible light, and the presence of oxygen, resulting in the formation of highly reactive and cytotoxic singlet oxygen. PDT has been shown to be more effective as the fluence rate decreases due to oxygen availability and the absence of photobleaching. On the other hand, Quantum Dot Light Emitting Diodes QLEDs- a new form of light source based on nanoparticles (quantum dots)- emerge as a potentially advantageous light source for certain types …


Organizational Health Literacy In Pediatric Cardiovascular Programs, Eva Gomez Aug 2025

Organizational Health Literacy In Pediatric Cardiovascular Programs, Eva Gomez

Graduate Doctoral Dissertations

Health literacy refers to a person’s ability to access, understand and use health-related information in order to effectively manage one's health and navigate healthcare experiences. This responsibility does not rest solely upon the individual; healthcare organizations also have a vital role in assisting individuals in accessing, understanding and using health information through their interactions with the healthcare system. Organizational health literacy (OHL) can serve as a strategy to ensure that all individuals have equitable access to health information and services. The Ten Attributes of a Health Literate Healthcare Organization established the foundational principles of organizational health literacy. The present study …


Exploring Transgender And Gender Expansive Youth's Experiences With Vicarious Minority Stress, Erin T. Pereida Aug 2025

Exploring Transgender And Gender Expansive Youth's Experiences With Vicarious Minority Stress, Erin T. Pereida

Graduate Doctoral Dissertations

In the United States (U.S.), transgender and gender expansive (TGE) youth experience elevated rates of depressive symptoms, self-harm behaviors, and suicidality compared to cisgender peers. Mental health professionals and researchers often use the gender minority stress model to explain these elevated rates, positing that stressors related to minority identity experienced above and beyond normative daily stress contribute to adverse mental health outcomes. One emerging component of the model requiring further investigation is vicarious minority stress; stress experienced indirectly through witnessing or learning of gender minority stressors affecting other TGD individuals or the community more broadly. The present study explored this …


The Role Of Androgen Receptor And B2/Alu Sine Rna Interaction In Hippocampal Dendritic Development, Troy A. Richter Aug 2025

The Role Of Androgen Receptor And B2/Alu Sine Rna Interaction In Hippocampal Dendritic Development, Troy A. Richter

Graduate Doctoral Dissertations

Once dismissed as “junk”, transposable elements have recently gained recognition for their regulatory roles, especially in the brain. During development, circulating androgens promote proper morphological development of hippocampal neurons. We and others have shown that murine B2 SINE RNA is a regulator in the rodent hippocampus. It is unknown, however, if B2 is necessary for the proper development of hippocampal neurons. This dissertation investigates the role of murine B2 in the development of primary hippocampal neurons in combination with androgen treatment. We first examined the role of ALU SINE and androgen receptor in a prostate cancer cell model and found …


Trauma Whipple At A Community Level 1 Trauma Center: A Case Report, Jessica A. Nicholson, Andrew G. Nicholson, Mahmoud K. Abd-El-Hafez, Pankti Shah, Mark J. Lieser, John M. Chipko Aug 2025

Trauma Whipple At A Community Level 1 Trauma Center: A Case Report, Jessica A. Nicholson, Andrew G. Nicholson, Mahmoud K. Abd-El-Hafez, Pankti Shah, Mark J. Lieser, John M. Chipko

Student Publications

The Whipple operation is oftentimes considered one of the most challenging and complex abdominal operations, usually reserved for duodenal and hepatopancreatobiliary malignancies. In cases of duodenal and/or pancreatic trauma with disruption of the biliary systems, a Whipple reconstruction can be performed. Such operative traumas are rare and carry with them a high level of morbidity and mortality. This case report presents a challenging 46-day clinical course of a 22-year-old African American female, who suffered multiple gunshot wounds, resulting in severe abdominal injuries. These injuries included a grade 3 duodenal injury, grade 4 pancreatic injury, and a grade 4 renal injury. …


A Case Study Of The Perceived Support Needs Of Community College Faculty, Ramona C. Shelton Aug 2025

A Case Study Of The Perceived Support Needs Of Community College Faculty, Ramona C. Shelton

Electronic Theses and Dissertations

This qualitative case study explored the perceptions of community college faculty members in Tennessee regarding the supports they feel they need to be successful academicians both inside and outside of the classroom. Thirteen faculty members participated in the study, representing the 4 faculty ranking categories at the institution: adjunct/part-time, new full-time, junior/untenured, and senior/tenured. Interviews were semi-structured to allow the participants the opportunity to share their honest experiences on what support needs they have, how those needs have been met, and what support areas they expect to emerge in the future. Four academic administrators also participated in the study in …


Resistance Training Load-Volume Effects On Maximal Strength, Isometric Force-Time Characteristics, And Force-Velocity Relationships, Chieh-Hsin Yu Aug 2025

Resistance Training Load-Volume Effects On Maximal Strength, Isometric Force-Time Characteristics, And Force-Velocity Relationships, Chieh-Hsin Yu

Electronic Theses and Dissertations

The investigations concerned the effects of resistance training programs with different load–volume configurations on multiple strength characteristics, including maximal strength, isometric force–time properties, and force–velocity (F–v) relationships. Following a review of training interventions across these variables, two ecologically valid resistance training prescriptions were compared: high-load, low-volume (HLLV) and moderate-load, moderate-volume (MLMV). Fourteen recreationally trained participants were grouped into either HLLV (three sets of two repetitions at ≥ 80% 1RM) or MLMV (three sets of ten repetitions at 60–80% 1RM), incorporated into the main lifts of a 4-week program. Strength was assessed using back squat one-repetition maximum …


Proto-Oncogene Hras Transcript Level And Overall Survival In Stages Ii And Iii Colorectal Cancer, Donghyun Kim, Saima Sharif, Juan Antonio Raygoza Garay, Avanish S. Bhakta, Patrick M. Boland, Michael J. Cavnar, Michelle L. Churchman, Hassan Hatoum, Lyen C. Huang, Joseph Kim, Richard Kim, Robert W. Lentz, Sarbajit Mukherjee, Mary T. O'Donnell, Benjamin Quartey, Matthew J. Reilley, Robert J. Rounbehler, Bodour Salhia, Bryan P. Schneider, Carlos H. Chan Aug 2025

Proto-Oncogene Hras Transcript Level And Overall Survival In Stages Ii And Iii Colorectal Cancer, Donghyun Kim, Saima Sharif, Juan Antonio Raygoza Garay, Avanish S. Bhakta, Patrick M. Boland, Michael J. Cavnar, Michelle L. Churchman, Hassan Hatoum, Lyen C. Huang, Joseph Kim, Richard Kim, Robert W. Lentz, Sarbajit Mukherjee, Mary T. O'Donnell, Benjamin Quartey, Matthew J. Reilley, Robert J. Rounbehler, Bodour Salhia, Bryan P. Schneider, Carlos H. Chan

Surgery Faculty Publications

Background: Mutational landscape is prognostic in colorectal cancer (CRC). Rat sarcoma (RAS) oncogenes, such as KRAS and NRAS, with driver mutations, portend poor survival outcomes, whereas pathologic mutations in HRAS are extremely rare, and their prognostic value remains uncertain. Methods: This retrospective study analyzed the Oncology Research Information Exchange Network (ORIEN) alliance tumor RNA-Seq data in Stages II and III CRC to investigate the association between RAS gene expression and survival outcomes. Results: High transcript levels of HRAS were associated with superior overall survival (OS). The high HRAS-associated OS benefit was most pronounced in patients with right-sided primary expressing low …


Β-Aminopropionitrile-Induced Thoracic Aortopathy Is Refractory To Cilostazol And Sildenafil In Mice, Samuel C. Tyagi, Sohei Ito, Jacob C. Hubbuch, Michael K. Franklin, Deborah A. Howatt, Hong S. Lu, Alan Daugherty, Hisashi Sawada Aug 2025

Β-Aminopropionitrile-Induced Thoracic Aortopathy Is Refractory To Cilostazol And Sildenafil In Mice, Samuel C. Tyagi, Sohei Ito, Jacob C. Hubbuch, Michael K. Franklin, Deborah A. Howatt, Hong S. Lu, Alan Daugherty, Hisashi Sawada

Surgery Faculty Publications

Thoracic aortopathies are life-threatening diseases including aneurysm, dissection, and rupture. Cilostazol, a phosphodiesterase (PDE) 3 inhibitor, and sildenafil, a PDE5 inhibitor, have been used clinically for peripheral arterial disease and erectile dysfunction or pulmonary hypertension, respectively. Recent studies report their effects on abdominal aortic aneurysm formation. However, their impacts on thoracic aortopathy remain unknown. In this study, we investigated whether cilostazol and sildenafil affect thoracic aortopathy induced by β-aminopropionitrile (BAPN) administration in mice. Bulk RNA sequencing analysis revealed that BAPN administration upregulated Pde3a transcription in the ascending aorta and Pde5a in both ascending and descending regions before thoracic aortopathy formation. …


Artificial Intelligence And The Law: A Discussion And Selections From The Collection, Wolf Law Library, William & Mary Law School Aug 2025

Artificial Intelligence And The Law: A Discussion And Selections From The Collection, Wolf Law Library, William & Mary Law School

Library Book Displays

On display in the Wolf Law Library August 2025 - January 2026.


Molecular And Clinical Insights Into Role Of Gper In Hepatocellular Carcinoma (Hcc), Hossain Ahmed Aug 2025

Molecular And Clinical Insights Into Role Of Gper In Hepatocellular Carcinoma (Hcc), Hossain Ahmed

Theses and Dissertations

Metabolic dysfunction–associated steatotic liver disease (MASLD), encompassing stages from steatosis (MASLD) to steatohepatitis (MASH), cirrhosis, and hepatocellular carcinoma (HCC), is the most prevalent chronic liver disease worldwide, yet molecular markers of progression remain limited. The G protein–coupled estrogen receptor (GPER), a non-genomic estrogen receptor with metabolic and anti-inflammatory roles, emerges as a candidate regulator in hepatic pathophysiology. In this Dissertation thesis, we have delineated for the first time clinicopathological assessment of liver biopsies across MASLD stages revealing a robust inverse correlation between GPER expression and disease severity. Higher GPER levels in early MASLD associated with favorable metabolic and biochemical profiles, …


Principles And Practice In Pediatric Vascular Trauma: Part 1: Scope Of Problem, Team Structure, Multidisciplinary Dynamics, And Solutions, Matthew T Harting, Natalie A Drucker, Mary T Austin, Matthew R Greives, Bryan A Cotton, S Keisin Wang, Derrick P Williams, Joseph J Dubose, Charles S Cox Aug 2025

Principles And Practice In Pediatric Vascular Trauma: Part 1: Scope Of Problem, Team Structure, Multidisciplinary Dynamics, And Solutions, Matthew T Harting, Natalie A Drucker, Mary T Austin, Matthew R Greives, Bryan A Cotton, S Keisin Wang, Derrick P Williams, Joseph J Dubose, Charles S Cox

The Brown Foundation: Institute of Molecular Medicine

As of 2020, penetrating injuries became the leading cause of death among children and adolescents ages 1-19 in the United States. For the patients who initially survive and receive advanced medical care, vascular injuries are a significant cause of morbidity and additionally trigger notable trauma team angst. Moreover, penetrating injuries can lead to life-threatening hemorrhage and/or limb-threatening ischemia if not addressed promptly. Vascular injury management demands timely and unique expertise, particularly for pediatric patients. As the frequency of vascular injuries requiring operative management increases, it becomes clear that an ad hoc approach is not ideal. An integrated team would provide …


Enigmatic Roles Of Complement Anaphylatoxin Signaling In Health And Disease, Anthony Shadid, Kathryn D Hok, Aleksey Y Domozhirov, Tingting Weng-Mills, Marie-Françoise Doursout, Nirmal K Banda, Marcos I Restrepo, Pooja Shivshankar Aug 2025

Enigmatic Roles Of Complement Anaphylatoxin Signaling In Health And Disease, Anthony Shadid, Kathryn D Hok, Aleksey Y Domozhirov, Tingting Weng-Mills, Marie-Françoise Doursout, Nirmal K Banda, Marcos I Restrepo, Pooja Shivshankar

The Brown Foundation: Institute of Molecular Medicine

Complement anaphylatoxins C3a and C5a are potent immunomodulators whose impact extends well beyond their traditional roles in innate immunity. Acting through G protein-coupled receptors C3aR, C5aR1, and C5aR2, these peptides take part in coordinating immune cell recruitment, vascular tone, and tissue remodeling. Yet their functions are deeply context-dependent: while they play essential roles in microbial clearance and immune coordination, their overactivation contributes to immunopathology in a wide range of diseases. The anaphylatoxins play key roles in early pathogen containment but can also drive cytokine storm and tissue damage, as in coronavirus disease 2019 (COVID-19) and bacterial sepsis. In autoimmune conditions, …


From The Battlefield To The Archive: Tracing Testimony In Holocaust Memory, Tiana M. Taliep Aug 2025

From The Battlefield To The Archive: Tracing Testimony In Holocaust Memory, Tiana M. Taliep

War, Diplomacy, and Society (MA) Theses

This thesis portfolio examines the evolving role of testimony in shaping public memory of World War II and the Holocaust. As the last generation of eyewitnesses passes, societies increasingly rely on preserved, mediated forms of testimony to understand and remember traumatic pasts. Testimony, whether handwritten, oral, visual, or digital, is not a neutral historical record but an interpretive act shaped by cultural, political, and technological forces. This portfolio argues that testimony functions as evidence and expression: it transmits trauma across generations while simultaneously reflecting the changing frameworks through which war and genocide are remembered.

The portfolio explores testimony in personal, …


Outcomes And Microbiological Patterns Of Bacteremia In Chemotherapy-Related Febrile Neutropenia At A Tertiary Facility In Kenya, Abhijit Ghose, Jasmit Shah, Anne Mwirigi, Charles Makasa, Felix Riunga Aug 2025

Outcomes And Microbiological Patterns Of Bacteremia In Chemotherapy-Related Febrile Neutropenia At A Tertiary Facility In Kenya, Abhijit Ghose, Jasmit Shah, Anne Mwirigi, Charles Makasa, Felix Riunga

Internal Medicine, East Africa

Introduction: Febrile neutropenia (FN) is a major cause of mortality and morbidity in patients with malignancy post-chmotherapy. Current guidelines for managing FN recommend starting empiric antibiotic therapy (EAT) promptly. The choice of antibiotic is based on the patient’s condition, local data on common microorganisms isolated, and their resistance patterns. Of note, there is a growing trend of isolating multi-drug–resistant gram-negative bacteria in these patients. In sub-Saharan Africa, there are insufficient data on the mortality rates of FN. There is also a lack of local epidemiologic data on the frequently isolated microorganisms and their antibiotic resistance patterns. This makes it challenging …


Investigating The Impact Of Instructor Presence In Lecture Videos On Learning Experiences: A Comparative Study, Keone K. Fuqua Aug 2025

Investigating The Impact Of Instructor Presence In Lecture Videos On Learning Experiences: A Comparative Study, Keone K. Fuqua

Graduate Theses and Dissertations (2019 - present)

As online learning continues to grow, understanding how instructional design features influence student experience becomes increasingly important. One critical feature in video-based instruction in instructor presence - the degree to which the instructor is visually or vocally present in the lesson. The purpose of this study was to investigate how varying levels of instructor presence in asynchronous lector videos affect students' perceived relatedness, satisfaction, engagement, content retention, and cognitive effort.

A mixed methods experimental design was employed, with 93 undergraduate and graduate students from a public university randomly assigned to one of three video lesson conditions: Full Presence (instructor visible …


Connecting The Dots: Teacher Self-Efficacy, Student-Teacher Relationships, And Behavior Management In Early Childhood, Courtney Lewis Aug 2025

Connecting The Dots: Teacher Self-Efficacy, Student-Teacher Relationships, And Behavior Management In Early Childhood, Courtney Lewis

Graduate Theses and Dissertations (2019 - present)

This study was designed to explore the relationships between teacher self-efficacy, student-teacher relationships, and use of behavior management strategies in early childhood education. Previous research suggests that effective early childhood education improves a child’s academic and social outcomes. This study sought to explore factors contributing to teacher effectiveness in preschool teachers. The hypotheses were that (1) teacher self-efficacy will directly affect student teacher relationships, (2) that studentteacher relationships will directly affect teacher’s frequency, confidence, and success of their behavior management strategies, and (3) that student-teacher relationships will act as a mediating variable between teacher self-efficacy and the frequency, confidence, and …


Out-Of-Band Anomaly Detection For Real Time Operating Systems, Jeffrey K. Holifield Aug 2025

Out-Of-Band Anomaly Detection For Real Time Operating Systems, Jeffrey K. Holifield

Graduate Theses and Dissertations (2019 - present)

Real Time Operating Systems (RTOS) are increasing present throughout the industrial, business, defense, and healthcare spaces. These lightweight and efficient operating systems are designed to run on embedded, resource constrained devices, often within cyber-physical systems (CPS). A defining characteristic ofRTOSs is that they are deterministic. Tasks are scheduled to run on fixed timelines within guaranteed execution windows. In Industry 4.0 applications for example, sensors must receive and process inputs within a fixed schedule to ensure products are properly manufactured. This requires guaranteed service at fixed time periods. To accomplish this, RTOSs must conform to worst case execution times (WCETs) as …


Associations Between Social Support, Social Control, And Stage Of Change With Self-Reported And Objectively Assessed Physical Activity In Adult Latino Dyads, Jemima C John, Minjae Lee, Soo K Park, Lorna H Mcneill, Deanna M Hoelscher, Susan M Schembre, Belinda M Reininger, Larkin L Strong Aug 2025

Associations Between Social Support, Social Control, And Stage Of Change With Self-Reported And Objectively Assessed Physical Activity In Adult Latino Dyads, Jemima C John, Minjae Lee, Soo K Park, Lorna H Mcneill, Deanna M Hoelscher, Susan M Schembre, Belinda M Reininger, Larkin L Strong

Faculty, Staff and Student Publications

Health behaviors such as physical activity (PA) are socially influenced, such that individuals from shared social networks or living environments may exhibit similar habits. This cross-sectional study examined associations of social support, social control, and family member stage of change with moderate-to-vigorous self-reported and objective PA in dyads of adult Hispanic family members. We used the Godin Leisure-Time Physical Activity Questionnaire to assess self-reported PA and accelerometry for objective PA. Validated scales assessed social support, social control, and stage of change. We performed multivariable multilevel analysis using generalized estimating equations (GEE) to account for within-dyad correlations. We conducted multivariable negative …


A Large-Scale Genome-Wide Study Of Gene-Sleep Duration Interactions For Blood Pressure In 811,405 Individuals From Diverse Populations, Pavithra Nagarajan, Thomas W Winkler, Amy R Bentley, Clint L Miller, Aldi T Kraja, Karen Schwander, Songmi Lee, Wenyi Wang, Michael R Brown, John L Morrison, Ayush Giri, Jeffrey R O'Connell, Traci M Bartz, Lisa De Las Fuentes, Valborg Gudmundsdottir, Xiuqing Guo, Sarah E Harris, Zhijie Huang, Mart Kals, Minjung Kho, Christophe Lefevre, Jian'an Luan, Leo-Pekka Lyytikäinen, Massimo Mangino, Yuri Milaneschi, Nicholette D Palmer, Varun Rao, Rainer Rauramaa, Botong Shen, Stefan Stadler, Quan Sun, Jingxian Tang, Sébastien Thériault, Adriaan Van Der Graaf, Peter J Van Der Most, Yujie Wang, Stefan Weiss, Kenneth E Westerman, Qian Yang, Tabara Yasuharu, Wei Zhao, Wanying Zhu, Drew Altschul, Md Abu Yusuf Ansari, Pramod Anugu, Anna D Argoty-Pantoja, Michael Arzt, Hugues Aschard, John R Attia, Lydia Bazzanno, Max A Breyer, Jennifer A Brody, Brian E Cade, Hung-Hsin Chen, Yii-Der Ida Chen, Zekai Chen, Paul S De Vries, Latchezar M Dimitrov, Anh Do, Jiawen Du, Charles T Dupont, Todd L Edwards, Michele K Evans, Tariq Faquih, Stephan B Felix, Susan P Fisher-Hoch, James S Floyd, Mariaelisa Graff, Charles Gu, Dongfeng Gu, Kristen G Hairston, Anthony J Hanley, Iris M Heid, Sami Heikkinen, Heather M Highland, Michelle M Hood, Mika Kähönen, Carrie A Karvonen-Gutierrez, Takahisa Kawaguchi, Setoh Kazuya, Tanika N Kelly, Pirjo Komulainen, Daniel Levy, Henry J Lin, Peter Y Liu, Pedro Marques-Vidal, Joseph B Mccormick, Hao Mei, James B Meigs, Cristina Menni, Kisung Nam, Ilja M Nolte, Natasha L Pacheco, Lauren E Petty, Hannah G Polikowsky, Michael A Province, Bruce M Psaty, Laura M Raffield, Olli T Raitakari, Stephen S Rich, Renata L Riha, Lorenz Risch, Martin Risch, Edward A Ruiz-Narvaez, Rodney J Scott, Colleen M Sitlani, Jennifer A Smith, Tamar Sofer, Maris Teder-Laving, Uwe Völker, Peter Vollenweider, Guanchao Wang, Ko Willems Van Dijk, Otis D Wilson, Rui Xia, Jie Yao, Kristin L Young, Ruiyuan Zhang, Xiaofeng Zhu, Jennifer E Below, Carsten A Böger, David Conen, Simon R Cox, Marcus Dörr, Mary F Feitosa, Ervin R Fox, Nora Franceschini, Sina A Gharib, Vilmundur Gudnason, Sioban D Harlow, Jiang He, Elizabeth G Holliday, Zoltan Kutalik, Timo A Lakka, Deborah A Lawlor, Seunggeun Lee, Terho Lehtimäki, Changwei Li, Ching-Ti Liu, Reedik Mägi, Fumihiko Matsuda, Alanna C Morrison, Brenda Wjh Penninx, Patricia A Peyser, Jerome I Rotter, Harold Snieder, Tim D Spector, Lynne E Wagenknecht, Nicholas J Wareham, Alan B Zonderman, Kari E North, Myriam Fornage, Million Veteran Program, Adriana M Hung, Alisa K Manning, James Gauderman, Han Chen, Patricia B Munroe, Dabeeru C Rao, Diana Van Heemst, Susan Redline, Raymond Noordam, Heming Wang Aug 2025

A Large-Scale Genome-Wide Study Of Gene-Sleep Duration Interactions For Blood Pressure In 811,405 Individuals From Diverse Populations, Pavithra Nagarajan, Thomas W Winkler, Amy R Bentley, Clint L Miller, Aldi T Kraja, Karen Schwander, Songmi Lee, Wenyi Wang, Michael R Brown, John L Morrison, Ayush Giri, Jeffrey R O'Connell, Traci M Bartz, Lisa De Las Fuentes, Valborg Gudmundsdottir, Xiuqing Guo, Sarah E Harris, Zhijie Huang, Mart Kals, Minjung Kho, Christophe Lefevre, Jian'an Luan, Leo-Pekka Lyytikäinen, Massimo Mangino, Yuri Milaneschi, Nicholette D Palmer, Varun Rao, Rainer Rauramaa, Botong Shen, Stefan Stadler, Quan Sun, Jingxian Tang, Sébastien Thériault, Adriaan Van Der Graaf, Peter J Van Der Most, Yujie Wang, Stefan Weiss, Kenneth E Westerman, Qian Yang, Tabara Yasuharu, Wei Zhao, Wanying Zhu, Drew Altschul, Md Abu Yusuf Ansari, Pramod Anugu, Anna D Argoty-Pantoja, Michael Arzt, Hugues Aschard, John R Attia, Lydia Bazzanno, Max A Breyer, Jennifer A Brody, Brian E Cade, Hung-Hsin Chen, Yii-Der Ida Chen, Zekai Chen, Paul S De Vries, Latchezar M Dimitrov, Anh Do, Jiawen Du, Charles T Dupont, Todd L Edwards, Michele K Evans, Tariq Faquih, Stephan B Felix, Susan P Fisher-Hoch, James S Floyd, Mariaelisa Graff, Charles Gu, Dongfeng Gu, Kristen G Hairston, Anthony J Hanley, Iris M Heid, Sami Heikkinen, Heather M Highland, Michelle M Hood, Mika Kähönen, Carrie A Karvonen-Gutierrez, Takahisa Kawaguchi, Setoh Kazuya, Tanika N Kelly, Pirjo Komulainen, Daniel Levy, Henry J Lin, Peter Y Liu, Pedro Marques-Vidal, Joseph B Mccormick, Hao Mei, James B Meigs, Cristina Menni, Kisung Nam, Ilja M Nolte, Natasha L Pacheco, Lauren E Petty, Hannah G Polikowsky, Michael A Province, Bruce M Psaty, Laura M Raffield, Olli T Raitakari, Stephen S Rich, Renata L Riha, Lorenz Risch, Martin Risch, Edward A Ruiz-Narvaez, Rodney J Scott, Colleen M Sitlani, Jennifer A Smith, Tamar Sofer, Maris Teder-Laving, Uwe Völker, Peter Vollenweider, Guanchao Wang, Ko Willems Van Dijk, Otis D Wilson, Rui Xia, Jie Yao, Kristin L Young, Ruiyuan Zhang, Xiaofeng Zhu, Jennifer E Below, Carsten A Böger, David Conen, Simon R Cox, Marcus Dörr, Mary F Feitosa, Ervin R Fox, Nora Franceschini, Sina A Gharib, Vilmundur Gudnason, Sioban D Harlow, Jiang He, Elizabeth G Holliday, Zoltan Kutalik, Timo A Lakka, Deborah A Lawlor, Seunggeun Lee, Terho Lehtimäki, Changwei Li, Ching-Ti Liu, Reedik Mägi, Fumihiko Matsuda, Alanna C Morrison, Brenda Wjh Penninx, Patricia A Peyser, Jerome I Rotter, Harold Snieder, Tim D Spector, Lynne E Wagenknecht, Nicholas J Wareham, Alan B Zonderman, Kari E North, Myriam Fornage, Million Veteran Program, Adriana M Hung, Alisa K Manning, James Gauderman, Han Chen, Patricia B Munroe, Dabeeru C Rao, Diana Van Heemst, Susan Redline, Raymond Noordam, Heming Wang

Faculty, Staff and Student Publications

Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discovered 22 novel gene-sleep duration interaction loci for blood pressure, mapped to 23 genes. Investigating these genes' functional implications shed light on neurological, thyroidal, bone metabolism, and hematopoietic pathways that necessitate future investigation for blood pressure management that caters to sleep health …


Corporate Ownership, Health System Affiliation, And Market Concentration Of Home Health Agencies, Kun Li, Shekinah Fashaw-Walters, M Kate Bundorf, Yucheng Hou Aug 2025

Corporate Ownership, Health System Affiliation, And Market Concentration Of Home Health Agencies, Kun Li, Shekinah Fashaw-Walters, M Kate Bundorf, Yucheng Hou

Faculty, Staff and Student Publications

This cross-sectional study examines how growing health system affiliation and corporate ownership models may potentially contribute to home health agency (HHA) market concentration.


Chance Or Strategy? Assessing The Unanticipated Policy Window For Active Transportation During The Covid-19 Pandemic: A Systematic Review, Katja Siefken, Michael Pratt, Juliana Mejía-Grueso, Adrian Bauman, Deborah Salvo, Catherine B Woods, Wanda Wendel-Vos, Justin Richards, J Jaime Miranda, Pedro C Hallal, Andrea Ramírez Varela Aug 2025

Chance Or Strategy? Assessing The Unanticipated Policy Window For Active Transportation During The Covid-19 Pandemic: A Systematic Review, Katja Siefken, Michael Pratt, Juliana Mejía-Grueso, Adrian Bauman, Deborah Salvo, Catherine B Woods, Wanda Wendel-Vos, Justin Richards, J Jaime Miranda, Pedro C Hallal, Andrea Ramírez Varela

Faculty, Staff and Student Publications

Physical activity (PA) policy is essential for promoting population-level PA by coordinating efforts across various sectors. Global crises like the COVID-19 pandemic can open policy windows, enabling rapid implementation of innovative policies. This study examined how policy windows shaped active transportation (AT) policies during the pandemic, resulting in infrastructural changes.

Methods: A systematic review using PubMed, Scopus, ProQuest-Coronavirus Research Database, Web of Science, WHO COVID-19 Research Database, PsycInfo, and SPORTDiscus conducted to characterize AT policy during the pandemic (2020-2023). Descriptive analyses were conducted in Stata. PROSPERO registration number: CRD42025644930.

Results: The search retrieved 3879 articles; 1162 were duplicates, leaving 2716 …


Accelerometer-Measured Chronoactivity And Type 2 Diabetes Risk: A Prospective Study In Uk Biobank Participants, Qiuyu Feng, Gali Albalak, Ko Willems Van Dijk, Jeroen H P M Van Der Velde, Qian Xiao, Raymond Noordam, Diana Van Heemst Aug 2025

Accelerometer-Measured Chronoactivity And Type 2 Diabetes Risk: A Prospective Study In Uk Biobank Participants, Qiuyu Feng, Gali Albalak, Ko Willems Van Dijk, Jeroen H P M Van Der Velde, Qian Xiao, Raymond Noordam, Diana Van Heemst

Faculty, Staff and Student Publications

Objective: We assessed whether timing of physical activity, independent from the total activity amount, - which we refer to as chronoactivity - is associated with type 2 diabetes (T2D) risk.

Methods: We included UK Biobank participants with valid accelerometry data (UK, exposure measurement: 2013-2015, follow-up till November 2023) and without diabetes mellitus at baseline (N = 89,439; mean age: 61.7 [SD:7.9] years). Relative hourly physical activity was calculated by dividing the average hourly clock time physical activity by the average hourly physical activity in a week. Participants were categorized into different chronoactivity clusters using k-means cluster analysis on relative hourly …


Evaluating The Antimicrobial Properties Of Different Dental Cleaning Tablets Against S Aureus Grown On Two Denture Base Materials, Sindi Vishaj, Alissa Villhauer, Mandi Morris, Donald M Belles, Daher Antonio Queiroz, Maria D Gonzalez, Ransome Van Der Hoeven Aug 2025

Evaluating The Antimicrobial Properties Of Different Dental Cleaning Tablets Against S Aureus Grown On Two Denture Base Materials, Sindi Vishaj, Alissa Villhauer, Mandi Morris, Donald M Belles, Daher Antonio Queiroz, Maria D Gonzalez, Ransome Van Der Hoeven

Faculty, Staff and Student Publications

Objectives: This study aimed to evaluate the antimicrobial efficacy of three commercially available denture cleaning tablets Efferdent, Polident, and Val-clean against Staphylococcus aureus biofilms formed on two denture base materials: milled polymethyl methacrylate (PMMA) and 3D printed denture resin.

Material and methods: Eighty samples were fabricated, with 40 specimens per denture base material: CAD/CAM milled PMMA (Lucitone Digital Fit LT; Dentsply Sirona, Charlotte, NC, USA) and 3D printed resin (Denture Base Resin; Formlabs Inc., Somerville, MA, USA). Each group was divided into four subgroups (n = 10), Efferdent, Polident, Val-clean, and deionized water (control). Surface roughness was measured using a …


Genome-Wide Approaches To Bacterial Strain Typing: A History And Review Of Recent Methodological Advances, William C Shropshire, Blake M Hanson, Samuel A Shelburne Aug 2025

Genome-Wide Approaches To Bacterial Strain Typing: A History And Review Of Recent Methodological Advances, William C Shropshire, Blake M Hanson, Samuel A Shelburne

Faculty, Staff and Student Publications

Purpose of review: Whole genome sequencing (WGS) has transformed bacterial strain typing, an essential tool for outbreak detection, antimicrobial resistance surveillance, and tracking clonal emergence across clinical, research, and public health settings. Herein, we will review recent advances in WGS-based bacterial strain typing methods for purposes of comparison and classification with a focus on improvements in variant identification, strain classification, and transmission assessment.

Recent findings: Advances in sequencing technologies as well as variant calling methodologies and parameter optimization have enhanced the precision and accuracy of single nucleotide variant identification. Hierarchical clustering of gene-by-gene strain typing, combined with novel data management …


Yizhi Sun: Profile Of The Newest Chbc Faculty Member., Danna Jaimes-Fajardo, Jeremy J. Smith, Lutishoor Salisbury Aug 2025

Yizhi Sun: Profile Of The Newest Chbc Faculty Member., Danna Jaimes-Fajardo, Jeremy J. Smith, Lutishoor Salisbury

University Libraries Faculty Publications and Presentations

Presents the research profile of Yizhi Sun, Assistant Professor, Chemistry and Biochemistry department. It highlights his research interests, education, and impact of his research.


The Power Of Social Capital For First-Generation College Students, Inez M. Gonzalez Perezchica Aug 2025

The Power Of Social Capital For First-Generation College Students, Inez M. Gonzalez Perezchica

Journal of College Access

First-generation college students (FGCS) face unique challenges in achieving career success, challenges which stem from limited access to social capital. Social capital refers to the value derived from access to social structures, which serve as resources that enable individuals to pursue and attain their interests (Coleman, 1988). Enhancing mentoring for FGCS requires an understanding of how social capital facilitates success and upward mobility. FGCS face information gaps that can hinder their ability to navigate college bureaucracy, advance their careers, and beyond. To address this information gap, FGCS can seek advisors and mentors, or institutional agents, who can provide critical insights …


Complete Issue, Claudia Martinez, Lorenzo M. Sianez Jr Aug 2025

Complete Issue, Claudia Martinez, Lorenzo M. Sianez Jr

Journal of College Access

No abstract provided.


Cultivating Connections: Toward A Framework For Equity In Social Capital Development In College And Career Pathways, Samantha L. Perez Aug 2025

Cultivating Connections: Toward A Framework For Equity In Social Capital Development In College And Career Pathways, Samantha L. Perez

Journal of College Access

The attention on college and career pathways over the last decade has revitalized interest in key activities like early career exploration, work-based learning, and labor market alignment of career and technical education. One essential element of this work, and perhaps among the most critical, has not received as much attention. Research shows that social capital—the relationships and networks an individual has and their ability to build, leverage, and mobilize them— is often how people get access to new information and educational and career opportunities; however, it is not something that most school systems have made an explicit priority for preparing …