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A Clinical Study On Triphaladi Compound And Shunthyadi Eye Drop In The Management Of Computer Vision Syndrome, Shashi Prakash Gupta, D. B. Vaghela

Indian Journal of Health Sciences and Biomedical Research KLEU

BACKGROUND:

Computer vision syndrome (CVS) is a group of symptoms which crop up from the extended viewing of the visual display terminals, when the demands of the task exceed the abilities of the viewer. The symptoms of CVS include eyestrain, dry eyes, burning sensation, headache, focusing difficulties, and neck and shoulder pain.

AIM:

This study aims to evaluate the efficacy of

Triphaladi

compound and

Shunthyadi

eye drops in the management of CVS.

MATERIALS AND METHODS:

In this trial, forty patients were registered, of which 37 completed the treatment. In Group A, 18 patients had been prescribed

Triphaladi

compound internally and …

Two-Dimensional-Quantitative Structure-Activity Relationship Studies Of A Novel Series Of Diaryl Furanone Derivatives An Approach To Design Selective And Effective Cyclooxygenase-2 Inhibitors, Manjula K. Chikkamath, Pratibha M. Huded, Swetha S. Kokatnur, Akshata S. Menasinakai, Mahesh B. Palkar

Indian Journal of Health Sciences and Biomedical Research KLEU

INTRODUCTION:

Over a decade, a large number of selective cyclooxygenase-2 (COX-2) inhibitors with diverse chemical characteristics have been designed but only a few have emerged as drugs.

MATERIALS AND METHODS:

In the present study, two-dimensional-quantitative structure-activity relationship (2D-QSAR) studies were performed on a set of 43 novel derivatives of diaryl furanone using V-Life Molecular Design Suite (MDS 3.5) QSAR plus module using multiple linear regression (MLR) and Partial Least Square (PLS) regression methods against a COX-2 enzyme.

RESULTS AND DISCUSSION:

PLS method has displayed a very significant prediction results. QSAR model was generated by a training set of 33 molecules …

Evaluation Of The Effects Of Laser Irradiation On The Rate Of Tooth Movement A Split-Mouth Study, Urvi Harish Mal, Manjunath Malagan

Indian Journal of Health Sciences and Biomedical Research KLEU

AIM AND OBJECTIVE:

The aim of this study is to evaluate the rate of tooth movement caused by laser during individual canine retraction in the maxillary arch.

MATERIALS AND METHODS:

The study was done on 10 patients requiring upper first premolar extraction on both the sides and individual canine retraction using closed NiTi coil spring with high anchorage. A split-mouth technique was carried out where the right quadrant was the experimental side and left quadrant was the control side. On experimental side, canine was irradiated with Ga-As semiconductor laser (wavelength – 940 nm, output – 0.2 mW for 25 s, …

Comparison Of Vitamin “C” Levels In Naturally Ripened And Artificially Ripened Mangoes, Jayashree Neelakantha Majagi, Vanishree Basavraj Jabannavar

Indian Journal of Health Sciences and Biomedical Research KLEU

INTRODUCTION:

Fruits are very good sources of micronutrients. In the present era, eating fruits is questionable due to hazardous effects of artificial ripener usage on fruits. Ascorbic acid (C

6

H

8

O

6

), a major antioxidant water-soluble vitamin, acts as a reducing agent for many metabolic reactions as a coenzyme. Since it is heat-labile, fruits remain as a prime source as they are eaten uncooked. Mangoes, Banana, and Papaya are the most commonly subjected fruits for artificial ripening. However, artificial ripeners such as ethephon and calcium carbide have antinutritional and hazardous effects on health. This study analyzed the …

Vitamin B12 Insufficiency In Excess Folic Acid Downregulates Methylenetetrahydrofolate Reductase Gene And Increases Homocysteine, Tumor Necrosis Factor-Alpha, And Oxidative Stress In Hepatocytes, Tejas Shah, Kalpana Joshi, Sanjay Mishra

Indian Journal of Health Sciences and Biomedical Research KLEU

OBJECTIVE:

Folate and Vitamin B12 (B12) are crucial for normal growth, development, and cellular functions. The aim of this study was to determine the effect of required and excess folic acid (FA) concentration and imbalance of FA and B12 caused due to folate fortification on hepatocytes health and function

in vitro

.

MATERIALS AND METHODS:

Human hepatocellular carcinoma (HepG2) cells were cultured in FA and B12 deficient media for 15 days and further were supplemented with required FA: (6 μM) and excess FA: (60 μM) individually and in combination with B12: (500 nM). We assessed HepG2 proliferation, viability, tumor necrosis …

Expression Of Estrogen Receptor, Progesterone Receptor, And Human Epidermal Growth Factor Receptor Type 2/Neu In Surface Epithelial Ovarian Tumors And Its Clinicohistopathological Correlation, Neeta Verma, Madhu Kumar, Mala Sagar, Suresh Babu, Atin Singhai, Nisha Singh, Sujata Dev, Vijay Kumar

Indian Journal of Health Sciences and Biomedical Research KLEU

BACKGROUND:

Ovarian cancers represent the 4

th

most frequent type of cancers among females and are the most common cause of death from gynecological cancers in the world.

AIMS AND OBJECTIVES:

The aim is to evaluate the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (HER2/neu) immunohistochemical markers in surface epithelial ovarian tumors and its clinicopathological correlation with CA-125 level, histological type, grading of tumors, and prognosis of ovarian tumors.

MATERIALS AND METHODS:

This study included 48 cases of surface epithelial ovarian tumors including serous, mucinous, and adenocarcinoma Not Otherwise Specified (NOS). After grossing …

Review Of Selected Herbal Phytoconstituents For Potential Melanoma Treatment, Bhaskar Kallappa Kurangi, Sunil Satyappa Jalalpure

Indian Journal of Health Sciences and Biomedical Research KLEU

Malignant melanoma is the most aggressive form of skin cancer, with a high mortality rate. The current chemotherapies have a relatively low success rate due to the development of multidrug resistance and side effects. Hence, there is need of discovering new compounds that are safe and more effective against melanoma to improve the efficiency and to lower the treatment cost for cancer care. Melanoma chemoprevention with natural herbal phytoconstituents is an emerging strategy to prevent, cure, or treat melanoma. This review summarizes the latest research in melanoma chemoprevention and treatment using the herbal phytoconstituents. Relevant mechanisms involved in the pharmacological …

The Role Of Microbiome In Cancer, R. B. Nerli, Shridhar C. Ghagane

Indian Journal of Health Sciences and Biomedical Research KLEU

No abstract provided.

Survival In A Case Of Aluminum Phosphide Poisoning With Severe Myocardial Toxicity, Priya Bansal, Subhash Giri, Rohit Bansal, Laxmikant Ramkumarsingh Tomar

Indian Journal of Health Sciences and Biomedical Research KLEU

Aluminum phosphide (AlP) is a commonly used pesticide (insecticide) in developing countries like India. It is also one of the most common and deadly causes of suicidal poisoning in rural areas, with a lethal dose of 150–500 mg (unexposed tablet) in adults. Death is due to the rapid release of phosphine gas which causes cellular and mitochondrial toxicity leading to cardiovascular collapse and multiorgan failure. Here, we describe a case of AlP poisoning in a young male who developed severe myocarditis and metabolic acidosis after consumption of 3 g of AlP. In spite of a poor predicted outcome, the patient …

Deep Cerebral Venous Thrombosis As A Presenting Feature Of Systemic Lupus Erythematosus, Chandra Mohan Sharma, Banshi Lal Kumawat, Kaushik Ramanlal Rana, Ankur Garg

Indian Journal of Health Sciences and Biomedical Research KLEU

Systemic lupus erythematosus (SLE) is an autoimmune disease with various systemic manifestations. Neurological manifestations include cognitive decline, headache, seizure, stroke, and aseptic meningitis. Cerebral venous sinus thrombosis (CVST) is a very rare manifestation of SLE and occasionally can be the presenting feature of SLE. However, thrombosis of a deep venous system as a presenting feature of SLE is scarcely reported. We report a case of a 42-year-old female who presented with a deep cerebral vein thrombosis and was subsequently diagnosed SLE. The clinician should be aware regarding this uncommon presentation of SLE as CVST. A high index of suspicion is …

Concurrent Infarction In Bilateral Middle Cerebellar Peduncles Rare Presentation Of Stroke, Chandra Mohan Sharma, Banshi Lal Kumawat, Ankur Garg, Vikas Sharma

Indian Journal of Health Sciences and Biomedical Research KLEU

Although some pathologies like demyelination have predilection for middle cerebellar peduncles (MCPs), infarction of bilateral MCP simultaneously is an exceedingly rare presentation of stroke. Patient was a 70-year-old smoker and hypertensive male presented with acute onset vertigo, imbalance while walking and slurred speech for 2 days and examination revealed horizontal nystagmus bilaterally, scanning speech with cerebellar signs and Modified Rankin Score (MRS) of 3. Magnetic resonance imaging brain showed symmetrical areas of diffusion restriction in both MCP, and there was occlusion of bilateral vertebral arteries (partial occlusion of right and complete occlusion of left) and basilar artery in computed tomography …

Clinical Evaluation Of Nasya Karma In Cervical Spondylosis Case Series, Sangeeta R. Tanwar, Anup B. Thakar, Rajkala Ramteke

Indian Journal of Health Sciences and Biomedical Research KLEU

Introduction:

Cervical spondylosis is one of the most common degenerative, neurological conditions of the cervical spine by which a major part of population is affected. In today's mobile era, for higher achievements and ambitions, man is moving faster to Mars life and is more prone to degenerative disorders. Apart from age, other risk factors for cervical spondylosis include occupations that may cause more stress on neck, certain neck injuries, incorrect posture while sitting or walking, smoking, sedentary lifestyle and genetic factors. Modern therapies such as analgesics, muscle relaxants, steroids, physiotherapies, and even operative procedures are not fulfilling the patients' goal …

A Morphometric Study Of Femoral Length, Anterior Neck Length, And Neck-Shaft Angle In Dry Femora A Cross-Sectional Study, Prabha Nand Chaudhary, V. S. Shirol, Rajendra D. Virupaxi

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

As the environment plays an important role in the development, the regional variation of the femur bone is influenced by geographical area, sex, stature, and heredity. In the present study, measurements on the adult human dry femora have been carried out. The knowledge of variations in the parameters of dry femora will help the orthopedicians and also assist prosthetists to design a suitable prosthesis for restoration of normal neck-shaft angle (NSA) and will also help forensic anthropologists to determine the sex.

Objectives:

The objectives of this present study is to determine the various parameters including femoral length, anterior neck …

Design, Formulation, And Evaluation Of, Fatima Sanjeri Dasankoppa, Pooja Solankiy, Hasanpasha N. Sholapur, Vilas G. Jamakandi, Vinuta M. Sajjanar, Pooja M. Walveka

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

The significant problem in the ocular drug delivery is the attainment of optimal drug concentration at the site of action. Development of therapeutic agents that require repeated long-term administration is a driver for the sustained release drug delivery systems, to result in less frequent dosing, and less invasive techniques. Therefore, to overcome the anatomical barriers and ocular bioavailability constrains, a novel drug delivery system

in situ

gels have been developed.

Materials and Methods:

The

in situ

gelling system comprises gellan gum, an anionic polymer responsible for the ionic gelation. Methylcellulose a nonionic polymer contributes for the viscosity and gels …

Influence Of Strength And Proprioception Training On Functional Ankle Stability Among Young Skaters, Priyanka Mudaliar, Snehal Dharmayat

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

Stability of the ankle joint during functional activities depends on the presence of intact neural input from proprioceptors in the joint capsules, ligaments, muscles, tendons, and skin. Roller skaters are prone for more ankle injuries due to the nature of the sport. Repetitive falls and sprains lead to deficits that account for decreased performance and increased risk of falls.

Purpose:

The purpose of this study is to determine the effect of strength and proprioceptive training on functional ankle stability among young skaters.

Design:

This was a single arm pre- and post-experimental study.

Settings:

The study was conducted at two …

Treatment Patterns In Type 2 Diabetes Mellitus A Cross-Sectional Study, Dhongadi Prashant, Sanjay Kambar

Indian Journal of Health Sciences and Biomedical Research KLEU

Introduction:

Diabetes is one of the most common noncommunicable diseases in the world. There is an epidemic of diabetes in developing and nondeveloping countries. Treatment patterns play a very important role in the control of blood glucose levels of the patient.

Methodology:

A total of 520 type 2 diabetes mellitus patients in the area of Urban Health Centre, Ashok Nagar, were interviewed with the help of a predesigned and pretested questionnaire. Data were collected by house-to-house visit.

Results:

Out of the 520 participants, 264 were male and 256 were female. Oral hypoglycemic agents were the most common modality of treatment …

A Cadaveric Study “Measurements Of Tricuspid Valve Using Cardiac Sizer In The North Karnataka Region”, Supriya Premkumar, Suresh P. Desai, R. D. Virupaxi

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

The right atrioventricular orifice is guarded by a complex called as tricuspid valve complex. The complex consists of atrioventricular orifice, annulus, leaflets, chordae tendineae, and papillary muscles. The right atrioventricular orifice passes the blood to the right ventricle in one-way direction, and this orifice is guarded by valve called as tricuspid valve. Tricuspid valve prevents the back flow of blood into the right atrium.

Materials and Methods:

This study was done on thirty human cadavers, which included 15 male and 15 female cadavers belonging to age group ranging from 50 to 70 years. Diameter of tricuspid valve was recorded …

Formulation And Characterization Of Oxiconazole-Loaded Emulgel For Topical Application, A. P. Gadad, Amol Prakash Magdum, P. M. Dandagi, U. B. Bolmal, Shriraj Kamat

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

Oxiconazole nitrate is a new topical broad spectrum antifungal agent used to treat superficial fungal infections. It has a low aqueous solubility due to which different techniques are employed to enhance its bioavailability. Emulgel has emerged as one of the most interesting topical drug delivery system for hydrophobic drugs like Oxiconazole as it has dual release control systems i.e. emulsion and gel.

Objective:

In the present work an attempt was made to prepare Emulgel of Oxiconazole nitrate for enhancing its topical delivery.

Materials and Methods:

Emulgel formulations were characterized by various parameters like pH, viscosity, spreadability, extrudability,

in vitro …

Female Factors Infertility Laparoscopic Evaluation At A Public Health Facility In Ilorin, Nigeria, Lukman Omotayo Omokanye, Sabi Ibrahim, Abdulwaheed Olajide Olatinwo, Kabir Abayomi Durowade, Sikiru Abayomi Biliaminu, Ganiyu Adekunle Salaudeen

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

Infertility is a problem of global proportions, the majority being the residents of developing countries. The contribution of female factor is assuming a tremendous proportion. Laparoscopy remains an indispensable tool in the evaluation of the fertility potential of these female partners.

Aims:

This study was aimed at determining the various causes of female factor infertility among female partners of infertile couple in a tertiary health facility.

Methods:

A cross-sectional observational study of ninety seven (97) eligible infertile women who underwent diagnostic laparoscopy between 1st January 2012 and 31st December 2015 were enrolled for the study. The data were analyzed …

Influence Of Occupation On Median Nerve Cross-Sectional Area In Apparently Healthy Volunteers, Anthony Chukwuka Ugwu, Benjamin Efiong Udoh, Alhaji Modu Ali, Mohammed Abba, Emmanuel Buba, Mohammed Yusuf Mohammed

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

Sonographic measurement of the median nerve has been proposed as a useful alternative to the electrodiagnostic test in the diagnosis of the carpal tunnel syndrome because of its ability to reveal morphological changes.

Objective:

The objective of this study was to investigate the influence of occupation, gender, and hand dominance on the median nerve cross-sectional area (MNCSA).

Methodology:

One hundred and eighty apparently healthy volunteers were recruited for the study. Hand dominance was ascertained in all volunteers. The device used was Voluson P8 ultrasound system with a 12-MHz transducer, using custom preset for musculoskeletal ultrasound. The Anteroposterior (D

1 …

Assessment Of Knowledge Regarding Hazards Of Tobacco Use Among Police Personnel In Belagavi City A Cross-Sectional Study, Sudheer Shivalingappa Mang, Appasaheb S. Wantamutte, Ashwini Narasannavar, Mubashir Angolkar

Indian Journal of Health Sciences and Biomedical Research KLEU

Introduction:

Tobacco is a serious threat to health and ranks second as a cause of death globally, and it also ranks fourth in its input to years of life lost. The worldwide tobacco related mortality rate reached up to 4 million per year in 1998 and is expected to become 10 million per year in 2030. This is more than the total deaths from tuberculosis, malaria, maternal, and major childhood conditions combined.

Objective:

The aim is to assess the level of knowledge regarding hazards of tobacco use among police personnel in Belagavi city.

Methodology:

This study design was a cross-sectional …

Analysis Of Risk Factors Of Late Preterm Birth A Case-Control Study, Soumya Patil, Kamal P. Patil

Indian Journal of Health Sciences and Biomedical Research KLEU

Objective:

The aim of this study is to identify the risk factors associated with late preterm births (LPBs).

Methodology:

This case-control study was conducted in the Department of Obstetrics and Gynecology, teaching hospital attached to KLE University's Jawaharlal Nehru Medical College, Belagavi during May 2015–April 2016. A total of 918 women were enrolled into the study, 459 in each group. Women who delivered between 34 and 36 weeks 6 days were considered cases and controls were women who delivered from 37 weeks onward immediately after a case occurred. Gestational age was confirmed with ultrasonography before 20 weeks. Data were collected …

Effect Of Scapular Proprioceptive Neuromuscular Facilitation On Shoulder Pain, Range Of Motion, And Upper Extremity Function In Hemiplegic Patients A Randomized Controlled Trial, Deepak Joshi, Jeba Chitra

Indian Journal of Health Sciences and Biomedical Research KLEU

Background and Purpose:

Poststroke shoulder pain is one of the most prevalent impairments (34%–86%) and it hinders the performance of daily activities and also interferes with stroke rehabilitation. The purpose of this study was to examine the effect of scapular proprioceptive neuromuscular facilitation (PNF) on shoulder pain, range of motion (ROM), and upper extremity (UE) function in hemiplegic patients.

Methods:

Thirty hemiplegic patients were recruited and randomly allocated to Group A (

n

= 15) and Group B (

n

= 15). Experimental group received conventional treatment plus scapular PNF-hold relax technique while control group received only conventional treatment comprised …

The Effect Of Periodontal Status And Occlusal Support On Masticatory Performance A Cross-Sectional Study, Priyanka Subramanian Iyer, Vinayak Kumbhojkar

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

The destruction of periodontal tissue caused by periodontitis affects the sensory function of the periodontal ligament, reduces the mechanical support of teeth, and ultimately results in reduced masticatory performance in natural dentitions. Research on those who have lost a large number of teeth and the effect of periodontal status on masticatory ability remains unknown.

Objective:

The aim of the study was to assess the correlation between the effect of periodontal status and occlusal support on masticatory performance among various age groups.

Materials and Methods:

A total of 240 patients included in the study were divided into three groups according …

Effect Of, Aryaa A. Ankalikar, A. H. M. Viswanathswamy

Indian Journal of Health Sciences and Biomedical Research KLEU

Context:

Phytochemical investigations of hydroalcoholic extracts of

Vitex trifolia

Linn and

Solanum nigrum

Linn suggest the presence of flavonoids, terpenoids, and steroids and have been traditionally claimed to be useful in the treatment of inflammation, fever, edema, and tuberculosis.

Aim:

In the present study, hydroalcoholic extract of the plants was evaluated for its free radical scavenging capacity against hydroxyl, hydrogen peroxide, and nitric oxide radicals, and it's

in vitro

anti-inflammatory potential.

Materials and Methods:

Hydroalcoholic extracts of

V. trifolia

L. and

S. nigrum

L. were studied at different concentrations for their scavenging ability against free radicals and their ability to …

“Comparison Of Preincisional Port Site Infiltration Of 0.5% Levobupivacaine Versus 0.5% Ropivacaine For Postoperative Pain Relief In Patients Undergoing Laparoscopic Appendicectomy A One Year Hospital-Based Double-Blind Randomized Controlled Trial”, Santosh Subarao Patil, Vandana A. Gogate

Indian Journal of Health Sciences and Biomedical Research KLEU

Introduction:

Administration of local anesthetic into the wound before incision has been found to reduce postoperative pain following laparoscopic surgery. Levobupivacaine and ropivacaine which are less cardiotoxic and neurotoxic than bupivacaine are being used for local infiltration.

Objective:

To compare the efficacy of preincisional port site infiltration of 0.5% levobupivacaine versus 0.5% ropivacaine for postoperative pain relief in patients undergoing laparoscopic appendicectomy.

Methodology:

By computer-generated randomization table, sixty adult patients undergoing elective laparoscopic appendicectomy under general anesthesia were divided into two groups. Group 1 patients received 14 mL of 0.5% levobupivacaine preincisional port site infiltration and Group 2 patients received …

A Study Of Knowledge, Attitude, And Practices Of Menstrual Health Among Adolescent School Girls In Urban Field Practice Area Of Medical College, Tumkur, Purva Shoor

Indian Journal of Health Sciences and Biomedical Research KLEU

Introduction:

Menstruation is a phenomenon unique to females. In India, limited access to products of sanitary hygiene and lack of safe sanitary facilities could increase the likelihood of resorting to unhygienic practices to manage menstruation.

Materials and Methods:

A cross-sectional study was conducted from April 2013 to April 2014 by interviewing 452 adolescent school girls using a semi-structured, pretested questionnaire. There were 6 schools and 1 PUC college in the study area. Data were analyzed using Epi Info 3.5.3.

Objectives:

The objectives of this study were (1) to study the knowledge and attitude toward menstruation among adolescent school girls, (2) …

One Year Cross-Sectional Study Of Association Between Androgenetic Alopecia And Benign Prostatic Hyperplasia In A Tertiary Care Hospital, Prarthana B. Desai, B. S. Manjunath Swamy, R. B. Nerli

Indian Journal of Health Sciences and Biomedical Research KLEU

Background:

Androgenetic alopecia (AGA) and benign prostatic hyperplasia (BPH) are both androgen-dependent disorders in which the enzyme 5-alpha reductase plays a key role in conversion of testosterone to dihydrotestosterone. The purpose of this study is to analyze the association between AGA and BPH.

Materials and Methods:

Male patients between the age group of 25–45 years attending dermatology outpatient department at a tertiary care hospital with AGA during the period January 2015–December 2015 were included in the study. Ethical clearance was obtained from the Institutional Ethics Committee of Human Subjects Research. A short questionnaire recording their particulars and a detailed dermatological …

Knowledge Of Anganwadi Workers Regarding Different Components Provided By Integrated Child Development Scheme A Cross-Sectional Study, Prithutam Bhattarai, Padmaja R. Walvekar, Ashwini Narasannavar

Indian Journal of Health Sciences and Biomedical Research KLEU

Introduction:

Integrated child development service (ICDS) program was launched on October 02, 1975 and is the world's largest and unique program for early childhood care and development. It is working in urban and rural areas through Anganwadi centers. The beneficiaries that come under ICDS are 0–6 year's children, pregnant and lactating women, and adolescent girls. There are six core services provided by ICDS through Anganwadis. It is very essential to assess the knowledge of Anganwadi workers (AWWs) about different components of ICDS.

Objective:

The objective of the study was to assess the knowledge status of AWW regarding different ICDS components …

Review Of Research Works Done On Generalized Anxiety Disorder At Institute For Postgraduate Teaching And Research In Ayurveda, Jamnagar, Divya S. Zala, Anup B. Thakar, Nilesh N. Bhatt

Indian Journal of Health Sciences and Biomedical Research KLEU

Generalized anxiety disorder (GAD) is one of the most common anxiety disorders characterized by persistent worrying, anxiety symptoms, and tension. It is most frequent anxiety disorder in primary care and associated with a significant economic burden owing to decreased work productivity and increased use of health-care services. GAD is a highly disabling illness, often complicated by multiple comorbidities, most commonly depression and other anxiety disorders. Being an alarming disease, it requires effective management. Ayurveda, with its holistic approach, can be helpful in such situation. In this direction, to assess the actual efficacy of different Ayurveda treatment modalities; few works have …