Digital Commons Network^™

Behavioral Neuroscience Of Drug Addiction And Mental Disorder, Mona Muzammil, Muzammil Arshad, Washain Muzammil

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

This book explores the molecular, cellular, and neurocircuitry systems in the brain that are responsible for drug addiction. Common neurobiological elements are emphasized that provide novel insights into how the brain mediates the acute rewarding effects of drugs of abuse and how it changes during the transition from initial drug use to compulsive drug use and addiction. The book provides a detailed overview of the pathophysiology of the disease. The information provided will be useful for neuroscientists in the field of addiction, drug abuse treatment providers, and undergraduate and postgraduate students who are interested in learning the diverse effects of …

Essays On Economic Behaviour, Yiting Guo

Lingnan Theses (MPhil & PhD)

My PhD thesis comprises three studies. The first study examines prosocial behavior; the second analyzes vaccination behavior; and the third investigates communicative behavior in the context of trade. Specifically, the first study investigates the impact of donation visibility on individual prosocial behavior. It develops a sequential-move model based on the prosocial behavior framework proposed by Benabou and Tirole (2006). In Stage 1, individuals decide whether to attend a charity event, and if so, in Stage 2, decide on the amount to donate. In this model, an individual’s decision to engage in prosocial behavior is influenced by three main factors: intrinsic …

Playing Catch Up: A Brief Look Into Modern Internet Culture And Its Impact On Adolescent Male Development, Xavier Bird

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

This doctoral paper argues that the internet, particularly the "manosphere," poses three significant threats to the development of adolescent males in the U.S.: the influence of misogynistic online personalities, the normalization of risky online behavior, and the spread of right-wing misinformation. The paper highlights the role of the COVID-19 pandemic in exacerbating these issues due to increased internet usage. Furthermore, it proposes a research study to investigate the link between exposure to online misogynistic content and aggressive behavior in schools, emphasizing the unique challenges of studying adolescents and their online culture. Finally, the paper stresses the urgent need for updated …

Applying Contextual Behavioral Science To Address Addictions In Monsters, Chase Hollander

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

The dominant essentialist paradigm in addiction treatment often conceptualizes addiction as a curse or plague which seizes the individual afflicted by it. Such views are reinforced by neurobiological interventions like Medication-Assisted Treatment (MAT). While MAT can reduce cravings and withdrawal symptoms, its long-term efficacy is mixed, and its emphasis on abstinence as a primary outcome limits its scope. Addiction is a multifaceted phenomenon shaped by physiological, psychological, social, and systemic factors—including stigma, moral judgment, and structural oppression. Essentialist approaches frequently pathologize individuals and obscure these broader influences. In contrast, contextual behavioral sciences and therapies aligned with functional contextualism such as …

Supporting Healthy Siblings In Pediatric Cancer: Advancing Relational Interventions To Heal Invisible Wounds, Kristen K. Wederski

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Healthy siblings of children diagnosed with cancer occupy a uniquely vulnerable position within the pediatric oncology landscape. Individuals within this population often demonstrate significant emotional distress and can experience long-term psychological challenges. Despite their risk, healthy siblings remain under-researched and under-supported compared to pediatric patients and caregivers. Existing interventions tend to prioritize individual coping skills and psychoeducation and often overlook the critical relational dynamics that shape healthy siblings' psychological adjustment. Grounded in systematic and relational theories, this paper proposes a paradigm shift toward relationally focused interventions that strengthen the caregiver-sibling bond as a core mechanism of change to foster resilience …

The Journey Of Psychotherapy: Understanding Therapeutic Technique Through Ultralight Thru Hiking, Emma Bossier

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

This paper explores several principles of ultralight backpacking as metaphors for developing one’s therapeutic technique. The tenets of ultralight thru hiking, when interpreted through a clinical lens, offer early clinicians insight into the importance of moving through fear and leaning into exploration, discomfort, and authenticity while on the journey of becoming a therapist. The experiences of numerous thru hikers are synthesized into five principles: Don’t Pack Your Fears, Be Present for the Journey, Slow Simplicity, Embrace the Suck (and The Stink), and Trail Legs. These principles do not define ultralight as carefreeness but rather offer a metaphor for the careful …

The Developmental Cohort Model Of Interpersonal Process Groups: A Clinician's Guide For University Counseling Centers, Lauren Caldas

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

The purpose of this paper is to outline a clinician's manual that guides providers in the development, facilitation, and maintenance of long-term interpersonal process groups (IPGs) within university counseling centers (UCCs). This manual also presents a new model: The Developmental Cohort Model (DCM), which utilizes a stepped model throughout a traditional student's college timeline. I will present this manual in the context of the Developmental Cohort Model (DCM), but it can certainly remain useful for any type of IPG. Research suggests that group therapy is an effective way to increase access to mental health care (Burlingame & Strauss, 2021) and …

Proposed Theoretical Model Of Pediatric Onset Multiple Sclerosis And Restrictive Eating Behaviors, Anna L. Smith

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Multiple Sclerosis (MS), a chronic, demyelinating, autoimmune disease that causes an array of physical and cognitive symptomatology, is commonly diagnosed in adulthood. Pediatric Onset Multiple Sclerosis (POMS) is characterized by diagnosis of the disease before age 18 and accounts for about 5% of MS cases. While there is a growing body of literature examining the impact of adult-onset multiple sclerosis on psychosocial functioning, research specifically addressing POMS remains limited. Moreover, there is a notable gap in the literature regarding the risk of eating disorders among individuals with POMS. This paper will explore a constellation of potential risk factors that may …

Code Before Clause: Building Canada’S Digital Defences Before Negotiating Trade, Barry Appleton

Articles & Chapters

Canada is about to give away the keys to its digital future — before it even decides what future it wants.

This paper argues that any exploratory discussions between Canada and the European Union on a digital trade agreement must be paused until Canada legislates a domestic digital sovereignty framework and builds the governance capacity to implement it.

Unleashing Nk Cells For Cancer Immunotherapy In Lung Cancer: Biologic Challenges And Clinical Advances, Quinlan Mclaughlin, Dorothy K Sojka, Kathleen Kennedy, Sytse J Piersma, Nan Sethakorn

2020-Current year OA Pubs

Natural killer (NK) cells are a crucial part of the innate immune system and serve as an important effector for killing tumor cells through direct cytolytic activity or immunomodulatory signaling to T cells and antigen presenting cells. NK cells are correlated with increased tumor control and better overall patient survival across various types of cancers including non-small cell lung cancer (NSCLC). Despite their promising potential for anti-tumor killing, NK cell function is often diminished within the tumor microenvironment. There are many factors that lead to decreased tumor-infiltrating NK cell killing, including immunoinhibitory factors from tumor cells and resident tissues, acquired …

Building An Interdisciplinary Workforce In Geroscience: Aligning Perspectives And Educational Goals, Iman M Al-Naggar, Miranda E Orr, Et Al.

2020-Current year OA Pubs

The National Institute on Aging-funded Geroscience Education and Training Network held the "Building an Interdisciplinary Workforce in Geroscience: Aligning Perspectives and Educational Goals" preconference workshop at the 2023 Gerontological Society of America's Annual Meeting. Parties involved in geroscience education and interested stakeholders addressed the development of didactic educational materials, training, and career development opportunities to equip learners with the skills to meet the demands of the emerging field of geroscience, from research to clinic and industry. Recent successes were presented, existing opportunities, gaps, and challenges identified and discussed, and solutions and future directions described.

Sars-Cov-2 Antibody Responses In Children Exhibit Higher Fcr Engagement And Avidity Than In Adults, Carolyn A Cohen, Ludivine Grzelak, Susan S Chiu, David Sc Hui, Mike Yw Kwan, Owen Ty Tsang, Wai Hung Chan, Yat Sun Yau, Kelly Wk Lee, Masashi Mori, Gaya K Amarasinghe, Samuel Ms Cheng, Leo Lm Poon, Malik Peiris, Sophie A Valkenburg

2020-Current year OA Pubs

As intrinsic differences in humoral immune response to SARS-CoV-2 between children and adults remain unclear, we improved characterisation by defining the kinetics, specificity and function of antibodies to SARS-CoV-2 in children (n = 146, aged 9.4 ± 4.8 years with n = 257 samples) compared to adults (n = 85, aged 39.5 ± 15.2 years with n = 122 samples). We used plasma samples from an infection and vaccination-naive cohort study with RT-PCR confirmed ancestral B.1* SARS-CoV-2 virus infection with asymptomatic or mild disease, collected in Hong Kong between March to December 2020, from acute (0-14 days post infection) to …

Does Green Stem Photosynthesis Affect Plant Drought Tolerance And Recovery In Avocado?, Nadia A. Valverdi, Paula Guzmán-Delgado, Gregory R. Goldsmith, Eleinis Ávila-Lovera

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Woody plants with green stems may have advantages over non-green-stemmed plants in that extra photosynthetic carbon gain has the potential to improve plant drought tolerance and aid drought recovery. However, most studies relating to green stem photosynthesis and drought tolerance have been conducted on non-horticultural plants under natural growing conditions. We investigated whether avocado green stem photosynthesis enhances drought tolerance and recovery. We applied light exclusion and drought treatments to 3-year-old potted trees of cultivars ‘Hass’ and ‘Fuerte’. Measurements of soil moisture, midday stem water potential, stem photosynthesis, bark chlorophyll concentration, concentration of sugars + starch and stem hydraulic conductivity …

Predicting Regional Cerebral Blood Flow Using Voxel-Wise Resting-State Functional Mri, Hongjie Ke, Bhim M Adhikari, Yezhi Pan, David B Keator, Daniel Amen, Yizhou Ma, Neda Jahanshad, Jessica A Turner, Theo G M Van Erp, Mohammed R Milad, Jair C Soares, Vince D Calhoun, Juergen Dukart, L Elliot Hong, Tianzhou Ma, Peter Kochunov

Faculty, Staff and Student Publications

Background: Regional cerebral blood flow (rCBF) is a putative biomarker for neuropsychiatric disorders, including major depressive disorder (MDD).

Methods: Here, we show that rCBF can be predicted from resting-state functional MRI (rsfMRI) at the voxel level while correcting for partial volume averaging (PVA) artifacts. Cortical patterns of MDD-related CBF differences decoded from rsfMRI using a PVA-corrected approach showed excellent agreement with CBF measured using single-photon emission computed tomography (SPECT) and arterial spin labeling (ASL). A support vector machine algorithm was trained to decode cortical voxel-wise CBF from temporal and power-spectral features of voxel-level rsfMRI time series while accounting for PVA. …

Blood And Neuronal Extracellular Vesicle Mitochondrial Disruptions In Schizophrenia, A Ankeeta, Ashutosh Tripathi, Bindu Pillai, Yizhou Ma, Joshua J Chiappelli, Keiko Kunitoki, Si Gao, Bhim M Adhikari, Consuelo Walss-Bass, Giselli Scaini, Peter Kochunov, Anilkumar Pillai, L Elliot Hong

Faculty, Staff and Student Publications

The high energy demand of the human brain obligates robust mitochondrial energy metabolism, while mitochondrial dysfunctions have been linked to neuropsychiatric disorders, including schizophrenia spectrum disorders (SSD). However, in vivo assessments that can directly inform brain mitochondrial functioning and its etiopathophysiological path to SSD remain difficult to obtain. We hypothesized that system and brain mitochondrial dysfunctions in SSD may be indexed by elevated cell-free mitochondrial DNA (cf-mtDNA) levels in the blood and in neuronal extracellular vesicles (nEVs). We also explored if these mtDNA marker elevations were associated with brain metabolites as measured by magnetic resonance spectroscopy (MRS). We examined blood …

Phase 1 Clinical Trial Of ¡Iniciando! La Adultez: A Culturally Tailored Intervention For Transitioning Latino Young Adults With Autism, Antonio F Pagán, Ana Esparza, Ana Ramirez, Miriam Ortiz, Linda Hernandez, Mary Beth Morgan, Geohanna Noel, Alejandro L Pagán, Jada Salas, Katherine Maurano, Grace Sattem, Leela Sydow, Noor Ahmed, Katherine A Loveland, Cecilia Montiel-Nava, Ron Acierno

Faculty, Staff and Student Publications

This Phase 1 clinical trial evaluated ¡Iniciando! la Adultez, a culturally adapted intervention for Latino autistic young adults (n = 56) and their parents (n = 63). Young adults showed significant post-treatment improvements on measures of social responsiveness (SRS-2), adaptive behavior (ABAS-3), executive functioning (BRIEF-A), quality of life (WHOQOL-BREF), transition readiness (TRS-A), coping self-efficacy (CSES), and emotion regulation (DERS-SF). Parents reported significant improvements in their perceptions of their child’s social responsiveness, adaptive behavior, and executive functioning, as well as increased transition readiness ratings. Notably, parents evinced a significant decrease in acculturative stress (RASI) and depressive symptoms (PHQ-9), however, …

Developing Deep Learning Methods For Cognitive Impairment Detection Based On Non-Invasive Data, Muath Alsuhaibani

Electronic Theses and Dissertations

Cognitive impairment detection is on the rise to help reduce the burden of healthcare costs on institutions and individuals. Mild Cognitive Impairment (MCI) is an early stage of cognitive decline progressing to Alzheimer’s disease (AD) or AD-related Dementia (ADRD). Detecting the early stages of AD/ADRD is crucial for early interventions among older adults to mitigate cognitive decline over time. However, the current diagnostic methods are often costly and/or invasive, such as MRI and PET scans. Thus, the search for non-invasive and cost-effective screening tools for the early detection of cognitive impairment using speech, language, visual, and motor data is growing. …

Surgeon Ergonomics While Performing Total Knee Arthroplasty, Cameron Dahman

Electronic Theses and Dissertations

One of the most prevalent hazards to orthopedic surgeons are musculoskeletal disorders with 97% of arthroplasty surgeons reporting procedural-related musculoskeletal pain and 66% of orthopedic surgeons reporting procedural-related musculoskeletal injury [1], [2], [3]. With the annual number of total knee arthroplasties (TKA) on the rise, orthopedic surgeons are taking on larger annual caseloads and retiring later in life [4], [5]. The goal of this study was to quantify postural demand for 11 discrete surgical steps of TKA to identify ergonomically unfavorable positions surgeons experience while operating. Four orthopedic surgeons performed TKA while their motions were recorded using marker-based motion capture. …

Influence Of Obesity On Knee Joint Mechanics: A Subject-Specific Musculoskeletal Modeling Approach, Ryan C. Knowles

Electronic Theses and Dissertations

Obesity has been consistently linked to knee osteoarthritis (KOA), a debilitating joint disease. While prior work has shown that obese individuals often walk with altered biomechanics compared to normal-weight (NW) individuals, which may accelerate KOA progression, less is known about how these mechanics affect load distribution between the medial and lateral tibiofemoral (TF) compartments, particularly during higher-demand activities. This study developed subject-specific musculoskeletal models of five obese and five NW individuals, incorporating CT-based bone measurements and individualized joint contact points. Simulations were driven by six degree-of-freedom (6DOF) kinematics obtained from high-speed stereo radiography (HSSR) to predict TF loading and associated …

Exhibiting Rural Consciousness: A Study Of State And Local Level Governance In Rural Higher Education, Steven J. Skadron

Electronic Theses and Dissertations

Evolving economies in Craig and Salida, CO, spurred community interest in joining Colorado Mountain College’s taxing district and bringing the college to their communities. When they sought to join, Craig had a local college embedded in its community that was governed by a state-level board; in contrast, Salida had no local college of its own. The two communities’ pursuit of a locally governed college raised a question about governing boards and whether one type of governing board might serve rural communities better. Using a framework of rural consciousness, this nonexperimental, cross-sectional, quantitative study employed data gathered from a survey instrument …

Recruiting, Retaining, And Culturally Sustaining Latine Teachers In A School District With A High Population Of Latine Students, Lisa Garcia Simms

Electronic Theses and Dissertations

Latine students make up 52% of the Denver Public Schools (DPS) population, yet only 23% of its teaching force is Latine. This imbalance has real implications for student experience and opportunity. In 2024, DPS commissioned the La Raza Report, which detailed challenges faced by Latine students and educators and called for systemic improvements. The findings highlighted a clear need to strengthen recruitment, retention, and culturally sustaining support for Latine educators.

This improvement science project investigated how DPS might improve the experiences of Latine teachers—engaging educators across career stages, with a particular focus on supporting early-career Latine teachers —through identity-affirming mentorship …

Examining Whiteness: A Narrative Inquiry Into Racial Identity Among White Women In Study Abroad Programs, Audrey Moreno Townsend

Electronic Theses and Dissertations

The purpose of this narrative inquiry study was to better understand race in contexts both domestically and abroad through the perspectives and experiences of white women who studied abroad outside of Europe and the Anglosphere. The investigation explored on how these experiences shaped white women’s understanding of racial identity upon returning to their home institutions. The research question which was addressed was: How do white women experience study abroad programming? Research highlights a critical gap in existing literature on this topic. While white women are centered in the study, it is contextualized considering how People of Color experience the world. …

Mrs. Katie Mosley

African American Funeral Programs

No abstract provided.

Linda Mercer Roberts

African American Funeral Programs

Funeral program for Linda Roberts. Service was held on August 23, 2025 in Nevils, Georgia

The Shift: Embracing Loving Kindness And Nurse Well-Being As A Standard Of Care, Margaret Mcgrath Brown, Jennifer Rodriguez

Creating Healthy Work Environments (CHWE)

In response to mounting evidence of clinician burnout, the US Surgeon General declared a call to action, “we need to build a culture that supports well-being. It’s time to break the traditional silence surrounding the suffering of health workers”[1]. Our clinicians’ suffering in survival mode was confirmed by the findings from participation in a 2021 multi-site study among 60 Magnet hospitals evaluating clinician wellbeing[2].

Our organization embarked on a top-down/bottom-up approach rooted in loving kindness and personal and professional development. Over time, a shift has occurred, and an intentional transformation began towards viewing nurse well-being as a standard of care. …

Building A High-Performing Critical Care Outreach Team: Transforming Care And Collaboration, Heather Joy Cook, Brittany M. Wells

Creating Healthy Work Environments (CHWE)

The Critical Care Outreach Team (CCOT) at our large urban university medical center has become a cornerstone of patient safety and care, driving a significant cultural shift in rapid response and interdisciplinary collaboration from 2014 to 2024. Through the adoption of the six American Association of Critical Care Nurses (AACN) Healthy Work Environment standards, the CCOT has not only reduced cardiac arrests outside of critical care areas but also fostered a collaborative relationship based on trust, clinical excellence, and patient safety among ward staff that has transformed the culture of Rapid Response activations.

Clinical excellence has not been the only …

Introduction Of Code Lavender To Support The Well-Being Of Clinical Staff After Critical Events, Shannon Souther, Eunyoung Lee, Milena Staykova

Creating Healthy Work Environments (CHWE)

Debriefing after critical events can benefit individual healthcare workers and create a healthier work environment within the interdisciplinary team. The desire to participate in interdisciplinary debriefing (IDD) among healthcare workers has been expressed in previous studies. However, it may be difficult for workers to debrief without strong, hospital-wide support.

Purpose: A pilot study was conducted, intended to introduce and measure the feasibility of a new modality to deliver IDD, “Code Lavender.” The new process was aimed at addressing a known barrier to IDD by offering hospital support.

Methods/Implementation: IDD was implemented in 3 ICU settings over a 3-month period. Code …

Fostering Excellence Through Development Of A Code Stroke Response Nurse, Emma Bingham

Creating Healthy Work Environments (CHWE)

Situation: Toronto Western Hospital (TWH) is a Regional Stroke Centre, meaning that patients suspected of stroke bypass other centres to access TWH. This designation results in care for neurologically complex patients, requiring efficient stroke protocols and proficient, knowledgeable clinicians. Notification of a patient en-route to the Emergency Department with a suspected stroke sets off a cascade of events that require a streamlined, coordinated approach; a Code Stroke.

Background: There were many factors reinforcing the need to reevaluate TWH’s Code Stroke protocol, including the change to administration of tenecteplase for ischemic stroke, significant wait times and subsequent unsafe patient ratios in …

Growing Dreams: Enabling Rural High School Students' Healthcare Career Futures Via A Summer Camp, Minerva Gonzales, Adrian Billings, John Dijo, Katie Miller

Creating Healthy Work Environments (CHWE)

Rural health systems and hospitals are foundational to the health and economy of rural communities. Although rural healthcare organizations face multiple challenges, one of the most significant is recruitment and retention of the workforce. According to the American Hospital Association (2022), rural areas account for nearly 70% of Health Professional Shortage Areas (HPSAs). In addition, recruitment to a rural community can be difficult and retainment is even more challenging (Cosgrave et al., 2019). With these challenges in mind, an interdisciplinary and multi-institutional team collaborated to initiate a rural healthcare summer camp for rural high school students from the region at …

Work Safety Climate, Heat-Related Illness, And Pesticide Risks Among Latino Farmworker Adolescents, Fiorella L.Carlos Chavez, Priscilla Carmiol-Rodriguez, Taylor J. Arnold, Evan P. Anderson, Alexandra Brewis, Amber Wutich, Keenan A. Pituch, Scott C. Carvajal, Thomas A. Arcury, David W. Coon

Creating Healthy Work Environments (CHWE)

Among Latino farmworker adolescents (FWA), previous studies found that almost 50% reported HRI and symptoms while working in the fields and that being an older adolescent (compared to a younger one) increased the probability of reporting work-related injuries and HRI. Furthermore, Latino FWA often lack work experience, which could lead to unsafe occupational behaviors. Work safety climate (WSC) is the degree to which a worker perceives management values production over safety. Evidence suggests that weak WSC could lead farmworkers to engage in fewer safety procedures, increasing their risk of occupational injuries. Nevertheless, WSC research on HRI and pesticide risk (PR) …