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Articles 162331 - 162360 of 5150765
Full-Text Articles in Entire DC Network
Chronic Illness Education 2025: Treatment, Resources, And Prevalence Of Depression Among Adolescents With Chronic Health Conditions, Daeho Kim, Elyse Vanderwoude, Francesca Settineri, James Moss, Karen Crile, Matthew Mellor, Rachele Willard, Sarah Farhat
Chronic Illness Education 2025: Treatment, Resources, And Prevalence Of Depression Among Adolescents With Chronic Health Conditions, Daeho Kim, Elyse Vanderwoude, Francesca Settineri, James Moss, Karen Crile, Matthew Mellor, Rachele Willard, Sarah Farhat
Patient Education Projects
No abstract provided.
Chronic Illness Education 2025: Hypertension Prevention Strategies Catered Towards Pre-Menopausal Women, Jack Summers, Juan Rios, Karli Monahan, Lara Thomas, Leah Abdallah, Noah Ramirez, Noor Ghanam, William Merchun
Chronic Illness Education 2025: Hypertension Prevention Strategies Catered Towards Pre-Menopausal Women, Jack Summers, Juan Rios, Karli Monahan, Lara Thomas, Leah Abdallah, Noah Ramirez, Noor Ghanam, William Merchun
Patient Education Projects
No abstract provided.
Chronic Illness Education 2025: Environmental And Psychosocial Interventions In Adolescent Depression, Christian Hausner, Deanna Brown, Erica Kruszewski, Mawadda Abdelhai, Mukund Jayaraju, Sabryn Leidlein, Trentin Ines, Tyrnan Mcgowan
Chronic Illness Education 2025: Environmental And Psychosocial Interventions In Adolescent Depression, Christian Hausner, Deanna Brown, Erica Kruszewski, Mawadda Abdelhai, Mukund Jayaraju, Sabryn Leidlein, Trentin Ines, Tyrnan Mcgowan
Patient Education Projects
No abstract provided.
Chronic Illness Education 2025: A Highly Misunderstood, Multifactorial Disease, Alexa Maruszewski, Ali Eidy, Chelsea Kumi, Hailey Hartmann, Jacob Pawlowski, Kinan Suliman, Laura Garcia, William Davie
Chronic Illness Education 2025: A Highly Misunderstood, Multifactorial Disease, Alexa Maruszewski, Ali Eidy, Chelsea Kumi, Hailey Hartmann, Jacob Pawlowski, Kinan Suliman, Laura Garcia, William Davie
Patient Education Projects
No abstract provided.
Chronic Illness Education 2025: Preventative Measures To Mitigate The Development Of Atherosclerotic Coronary Artery Disease, Alexander Orr, Celina Wu, Elijah Marquez, Fateh Ahmad, Kendyll Gartrelle, Logan Harrison, Mia Sooch, Zahra Chehab, Emilio Espinal
Chronic Illness Education 2025: Preventative Measures To Mitigate The Development Of Atherosclerotic Coronary Artery Disease, Alexander Orr, Celina Wu, Elijah Marquez, Fateh Ahmad, Kendyll Gartrelle, Logan Harrison, Mia Sooch, Zahra Chehab, Emilio Espinal
Patient Education Projects
No abstract provided.
Chronic Illness Education 2025: Local Action, Lower Pressure- Resources To Advocate For Improvement In Hypertension Within The Community, Carinne Jarvis, Elinor Harrison, George Yalamanchili, Kamakashi Sharma, Mackenzie Fitzgerald, Neel Lachhwani, Nimr Assaf, Richard Tuttle
Chronic Illness Education 2025: Local Action, Lower Pressure- Resources To Advocate For Improvement In Hypertension Within The Community, Carinne Jarvis, Elinor Harrison, George Yalamanchili, Kamakashi Sharma, Mackenzie Fitzgerald, Neel Lachhwani, Nimr Assaf, Richard Tuttle
Patient Education Projects
No abstract provided.
Chronic Illness Education 2025: Resources To Improve Risk Of Hypertension, Bruna Storch Dos Santos, Bryce Brophy, Chonling Liu, Emily Webber, Izzy Havis, Janet Brenya, Noma Imudia, Eli Jarjous
Chronic Illness Education 2025: Resources To Improve Risk Of Hypertension, Bruna Storch Dos Santos, Bryce Brophy, Chonling Liu, Emily Webber, Izzy Havis, Janet Brenya, Noma Imudia, Eli Jarjous
Patient Education Projects
No abstract provided.
Chronic Illness Education 2025: School-Centered Interventions To Address Childhood Obesity, Aaron Yang, Amanda York, James Mcknight, Madison Jordan, Myron Shaba, Riley Marchin, Rita Pisegna, Constantine Tangalos
Chronic Illness Education 2025: School-Centered Interventions To Address Childhood Obesity, Aaron Yang, Amanda York, James Mcknight, Madison Jordan, Myron Shaba, Riley Marchin, Rita Pisegna, Constantine Tangalos
Patient Education Projects
No abstract provided.
Chronic Illness Education 2025: Emotional And Behavioral Concerns With Limited Support, Ahmed Alzubaidi, Ambrielle Stoltz-Bango, Grace Doakes, Ikenna Oduocha, Isaak Miller, Kelly-Ozze Bollou, Marta Haireek, Wyatt Feldman
Chronic Illness Education 2025: Emotional And Behavioral Concerns With Limited Support, Ahmed Alzubaidi, Ambrielle Stoltz-Bango, Grace Doakes, Ikenna Oduocha, Isaak Miller, Kelly-Ozze Bollou, Marta Haireek, Wyatt Feldman
Patient Education Projects
No abstract provided.
Chronic Illness Education 2025: Education And Resources To Improve Pediatric Type I Diabetes Mellitus Care Within Schools And Child Care Services, Alexander Seidel, Alexandra Thomas, Christine Larrea, Daven Sarikonda, Jack Gurwin, Maria Karla Bermudez Pineiro, Matthew Mello, Sana Soman
Chronic Illness Education 2025: Education And Resources To Improve Pediatric Type I Diabetes Mellitus Care Within Schools And Child Care Services, Alexander Seidel, Alexandra Thomas, Christine Larrea, Daven Sarikonda, Jack Gurwin, Maria Karla Bermudez Pineiro, Matthew Mello, Sana Soman
Patient Education Projects
No abstract provided.
Chronic Illness Education 2025: Navigating Depression And Anxiety Amid Socioeconomic Strain, Afrah Ansari, Candice Miller, Elizabeth Heinz, Joshua Teso, Muhammad Idrees, Omolola Suleiman, Sospeter Machani, Celia Somers
Chronic Illness Education 2025: Navigating Depression And Anxiety Amid Socioeconomic Strain, Afrah Ansari, Candice Miller, Elizabeth Heinz, Joshua Teso, Muhammad Idrees, Omolola Suleiman, Sospeter Machani, Celia Somers
Patient Education Projects
No abstract provided.
Chronic Illness Education 2025: Depressive Symptoms And Treatment Hesitancy In A Middle-Aged Male Living Alone, Abdulrahman Altatan, Abigail Biddix, Joseph Kunnappilly, Katherine Zhang, Kehinde Bolaji, Kyrillos Ayoub, Maya Fajardo, Michael Niculcea
Chronic Illness Education 2025: Depressive Symptoms And Treatment Hesitancy In A Middle-Aged Male Living Alone, Abdulrahman Altatan, Abigail Biddix, Joseph Kunnappilly, Katherine Zhang, Kehinde Bolaji, Kyrillos Ayoub, Maya Fajardo, Michael Niculcea
Patient Education Projects
No abstract provided.
A Quantitative Examination Of The Sexual Health Of Aging Black Men In Rural South Africa, Esihle Lupindo
A Quantitative Examination Of The Sexual Health Of Aging Black Men In Rural South Africa, Esihle Lupindo
Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–
This dissertation uses survey data primarily from Wave 1 of the Health and Aging in Africa: Longitudinal Study of In-depth Community in South Africa (HAALSI) which was collected in 2015 to study the sexual health of Black men in rural Mpumalanga, South Africa. Broadly speaking, I examine aging men’s sexual health as it related to HIV, well-being, loneliness, social networks and disclosure. The definition that I use for sexual health was coined by MacPhail and Campbell (2001) who define it as “not only sexual practices but also what people know and believe about sex, particularly what they think is natural, …
Activation Of Toll-Like Receptor 2 Promotes The Expression Of Inflammatory Mediators And Cell Proliferation Of Human Polycystic Kidney Disease Cells, Yang Zhang, Matthew Plansinis, Sophia Peak, Elisabeth Weber, Aiping Wei, Yu Xu, Madelyn Ross, Abigail Leagjeld, Darren P. Wallace, Yan Zhang
Activation Of Toll-Like Receptor 2 Promotes The Expression Of Inflammatory Mediators And Cell Proliferation Of Human Polycystic Kidney Disease Cells, Yang Zhang, Matthew Plansinis, Sophia Peak, Elisabeth Weber, Aiping Wei, Yu Xu, Madelyn Ross, Abigail Leagjeld, Darren P. Wallace, Yan Zhang
Michigan Tech Publications
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the progressive enlargement of fluid-filled cysts, leading to a decline in renal function. Toll-like receptors (TLR)-2 and TLR4 are pattern recognition receptors and components of the innate immune response. We found that mRNA levels for TLR2 and TLR4, an adaptor protein MyD88, and the transcription factor NF-κB were elevated in the kidneys of ADPKD patients and PKD mice. There was decreased expression of IκBα, an inhibitory protein sequestering NF-κB in the cytosol, and increased NF-κB nuclear translocation in human ADPKD kidneys compared with normal human kidneys (NHK). Pam3CSK4, a synthetic TLR2 …
Performance Characterization And Mechanistic Study Of Dry Process Wr/Sbs Composite Modified Asphalt Mixture, Hongfu Liu, Xiangyang Ren, Wenwen Ge, Zhengwei Yi, Dongzhao Jin, Xinghai Peng, Songtao Lv
Performance Characterization And Mechanistic Study Of Dry Process Wr/Sbs Composite Modified Asphalt Mixture, Hongfu Liu, Xiangyang Ren, Wenwen Ge, Zhengwei Yi, Dongzhao Jin, Xinghai Peng, Songtao Lv
Michigan Tech Publications
The dry process modification is characterized by simplicity, flexibility, low energy consumption, and low pollution, making it an ideal choice in pavement repair engineering. This study aims to optimize the use of waste rubber powder and SBS modifiers in dry process composite modification by preparing dry process WR/SBS composite modified particles (WR/SBS CMP) using a twin-screw extruder. The optimum mixing content of modified particles was determined through comparative analysis of pavement performance of dry process WR/SBS composite modified, wet-process SBS-modified, and matrix asphalt mixtures. The rheological properties and modification mechanism of the asphalt binder extracted from these mixtures were tested …
Misinformation Regulations: Early Evidence On Corporate Social Media Strategy, Richard M. Crowley, Yun Lou, Samuel T. Tan, Liandong Zhang
Misinformation Regulations: Early Evidence On Corporate Social Media Strategy, Richard M. Crowley, Yun Lou, Samuel T. Tan, Liandong Zhang
Research Collection School Of Accountancy
Against the backdrop of an increasing threat of misinformation on social media, several countries have enacted regulations to curb the spread of misinformation. This study examines how corporate social media strategy responds to misinformation regulations. Using a large cross-country dataset of corporate tweets and a stacked regression analysis, we show that misinformation regulations lead to less corporate social media disclosure. This result suggests that by deterring misinformation, these regulations reduce firms’ need to use social media to counteract its adverse effects. Additional analyses show that the effect is more pronounced among countries with higher social media usage and countries with …
Digital Economy Innovation In The Indo-Pacific: Towards A 'Singapore Effect'?, J.G. Allen, Qiu Xu Martin Liao
Digital Economy Innovation In The Indo-Pacific: Towards A 'Singapore Effect'?, J.G. Allen, Qiu Xu Martin Liao
Research Collection Yong Pung How School Of Law
This paper examines the rise of Digital Economy Agreements (DEAs) in the Indo-Pacific as a strategic response to digital trade fragmentation and great power competition. Focusing on Singapore’s leadership, we introduce the ‘Singapore Effect’ – a model of regulatory influence distinct from others, such as the ‘Brussels Effect’ and ‘Beijing Effect.’ Unlike market-driven regulatory diffusion, the Singapore Effect emphasizes interoperability, norm entrepreneurship, and mini-lateralism, enabling middle powers to shape digital trade governance. We analyze DEA formation, implementation challenges in national law, and Singapore’s role as a bridge between diverse regulatory regimes. DEAs’ flexible, modular structure allows for incremental regulatory alignment …
Harnessing Zakat To Drive Inclusive Economic Growth: Prospects And Challenges, Moh Najikhul Fajri, Andini Kusumawardhani
Harnessing Zakat To Drive Inclusive Economic Growth: Prospects And Challenges, Moh Najikhul Fajri, Andini Kusumawardhani
Journal Of Middle East and Islamic Studies
This study aims to analyze the role of zakat in promoting local inclusive economic growth in Indonesia. This research uses secondary panel data of 34 provinces during 2017-2022. The analysis techniques used in this study include the Poverty Equivalent Growth Rate (PEGR) inclusive economic growth measurement method and the Static Panel Regression Fixed Effect Model. This study concludes that zakat is proven to be an effective instrument in promoting inclusive economic growth in Indonesia, with a significant impact on income distribution even though its potential is still not optimized. Unique findings reveal that inclusive growth recovered faster than GDP post-pandemic, …
Extubation Decisions With Predictive Information For Mechanically Ventilated Patients In Icu, Guang Cheng, Jingui Xie, Zhichao Zheng, Haidong Luo, Oon Cheong Ooi
Extubation Decisions With Predictive Information For Mechanically Ventilated Patients In Icu, Guang Cheng, Jingui Xie, Zhichao Zheng, Haidong Luo, Oon Cheong Ooi
Research Collection Lee Kong Chian School Of Business
Weaning patients from mechanical ventilators is a crucial decision in intensive care units (ICUs), significantly affecting patient outcomes and the throughput of ICUs. This study aims to improve the current extubation protocols by incorporating predictive information on patient health conditions. We develop a discrete-time, finite-horizon Markov decision process with predictions of future state to support extubation decisions. We characterize the structure of the optimal policy and provide important insights into how predictive information can lead to different decision protocols. We demonstrate that adding predictive information is always beneficial, even if physicians place excessive trust in the predictions, as long as …
Can Lower(Ed) Expert Opinions Lead To Better Consumer Ratings?: The Case Of Michelin Stars, Xingyi Li, Yiting Deng, Puneet Manchanda, Bert De Reyck
Can Lower(Ed) Expert Opinions Lead To Better Consumer Ratings?: The Case Of Michelin Stars, Xingyi Li, Yiting Deng, Puneet Manchanda, Bert De Reyck
Research Collection Lee Kong Chian School Of Business
Expert opinion exerts tremendous influence on the purchase journey, but its effect on overall consumer experience is ambiguous because it can give rise to both “expectation” and “reputation” effects. This paper explores the effect of expert opinions on consumer experience via the lens of consumer reviews in the restaurant industry, where the expert opinions are conveyed by Michelin stars. The paper uses a unique data set based on the Michelin Guide for Great Britain & Ireland from 2010 to 2020. The data include consumer reviews on TripAdvisor for all restaurants that were awarded Michelin stars during this period and a …
Physical Work Environments: An Integrative Review And Agenda For Future Research, Bukky Akinsanmi Oyedeji, Yea Hee Ko, Sunkee Lee
Physical Work Environments: An Integrative Review And Agenda For Future Research, Bukky Akinsanmi Oyedeji, Yea Hee Ko, Sunkee Lee
Research Collection Lee Kong Chian School Of Business
This review examines the effect of physical work environments—the dedicated, tangible spaces where employees carry out their professional tasks—on organizational processes and outcomes. We synthesize decades of research across various disciplines using a conceptual framework that defines physical work environments along three key dimensions: ambience, spatial configuration, and aesthetics. These dimensions are analyzed for their effects on both internal stakeholders, such as employees, and external stakeholders, including clients, suppliers, and investors. Our analysis reveals two major themes in prior research: (1) task accomplishment, which focuses on how physical work environments influence physical and mental health, motivation and attitudes, as well …
Multi-Period Portfolio Allocation: A One-Shot Stochastic Optimization Approach, Peng Liu, Chyng Wen Tee, Xiaofei Xu
Multi-Period Portfolio Allocation: A One-Shot Stochastic Optimization Approach, Peng Liu, Chyng Wen Tee, Xiaofei Xu
Research Collection Lee Kong Chian School Of Business
Multi-period portfolio optimization is a central problem in finance, yet it is computationally intractable for traditional dynamic programming methods due to the curse of dimensionality. This paper develops a tractable and theoretically grounded 'one-shot' stochastic optimization framework that recasts the sequential decision problem into a single, high-dimensional optimization task. Our approach models the predictive distribution of factor returns using Gaussian Processes (GPs), allowing it to capture complex, non-linear market dynamics. We make three primary contributions. First, for the special case of a linear GP kernel, we derive an analytical solution for the optimal portfolio path, providing a clear economic interpretation …
Political Ecologies Of Storage For The 21st Century, Sayd Randle, Matthew Archer
Political Ecologies Of Storage For The 21st Century, Sayd Randle, Matthew Archer
Research Collection College of Integrative Studies
New resource storage arrangements are proliferating rapidly both in terms of physical infrastructures-for the storage of things like "clean" energy, nuclear waste, carbon dioxide, fresh water, and data-and as part of a set of discursive moves that reinforce a vision of a near future world in which problems of climate change mitigation and adaptation in particular (but also issues like energy security, water security, industry growth, etc.) are solved through eco-modernist techno-fixes. This Symposium sketches the contours of a framework we term political ecologies of storage. In doing so, we treat storage as both a potent imaginary and a concrete …
Seasonal And Landscape-Driven Variations In Forage Resources Of Apis Mellifera Scutellata: Implications For Pollination Sustainability And Colony Health In Taita Taveta County, Kenya, Mary Chege, Mbatha B. Wambua, Wambua J. Kilonzo, Sevgan Subramanian, Beatrice T. Nganso
Seasonal And Landscape-Driven Variations In Forage Resources Of Apis Mellifera Scutellata: Implications For Pollination Sustainability And Colony Health In Taita Taveta County, Kenya, Mary Chege, Mbatha B. Wambua, Wambua J. Kilonzo, Sevgan Subramanian, Beatrice T. Nganso
All Peer-Reviewed Publications
Seasonality and land-use change are key factors influencing forage availability for managed honey bee colonies, yet knowledge of forage identity and how these factors influence forage availability remains limited in Africa. To address these gaps, we used DNA metabarcoding to identify nectar and pollen plant species supporting the nutrition of the African savannah honey bee, Apis mellifera scutellata, across different land-use/land cover types and seasons in Taita Taveta County, Kenya. We identified 224 forage plant species from 65 families, with Asteraceae, Fabaceae, and Myrtaceae being the top contributors. Forage availability was significantly influenced by landscape and season, with honey bees …
Longitudinal Surveillance Of Aedes Aegypti (Diptera: Culicidae) In Urban Coastal Kenya: Population Dynamics, Blood Feeding Frequency And Dengue Virus Infection Rates, Josephine Osalla, Louis Clement Gouagna, Gilbert Rotich, Maureen Nzilani, Penina Safari, Kennedy Senagi, Francis Mutuku, Baldwyn Torto, David P. Tchouassi
Longitudinal Surveillance Of Aedes Aegypti (Diptera: Culicidae) In Urban Coastal Kenya: Population Dynamics, Blood Feeding Frequency And Dengue Virus Infection Rates, Josephine Osalla, Louis Clement Gouagna, Gilbert Rotich, Maureen Nzilani, Penina Safari, Kennedy Senagi, Francis Mutuku, Baldwyn Torto, David P. Tchouassi
All Peer-Reviewed Publications
The coastal region of Kenya has emerged as a focal point for urban dengue virus transmission driven by Aedes aegypti as the primary vector. To gain a deeper understanding of the epidemiological situation, we carried out a year-long longitudinal study (December 2021- November 2022) of the population dynamics of A. aegypti through weekly mosquito surveys using ovitrap and CO2-baited Biogents (BG) mosquito traps in Ukunda, an urban township in the coastal region. Aedes eggs laid in ovitraps were exclusively A. aegypti with 80.8% mean hatch rate. A total of 35,109 adult A. aegypti were captured, with twice as many females …
Enhancing Phenotyping Accuracy For Selection Of Urochloa Spp. Tolerant Genotypes To Red Spider Mite (Oligonychus Trichardti), Paula Espitia-Buitrago, José Miguel Cotes Torres, Luis Miguel Hernández, Juan Andres Cardoso, Frank Chidawanyika, Rosa N. Jauregui
Enhancing Phenotyping Accuracy For Selection Of Urochloa Spp. Tolerant Genotypes To Red Spider Mite (Oligonychus Trichardti), Paula Espitia-Buitrago, José Miguel Cotes Torres, Luis Miguel Hernández, Juan Andres Cardoso, Frank Chidawanyika, Rosa N. Jauregui
All Peer-Reviewed Publications
The red spider mites are a major biotic limitation to productivity for Brachiaria (Urochloa spp.) grasses in tropical Eastern Africa, causing severe economic losses mainly in the dry seasons. However, due to the lack of reports of integrated pest management strategies, genetic resistance can play a crucial role in Brachiaria-based livestock systems, minimising the impact of this pest. The objective of this study was to develop and validate a methodology for accurately categorising resistance responses in Urochloa genotypes to identify potential sources of resistance to the Western Kenya red spider mite Oligonychus trichardti (Meyer 1974). Accordingly, 25 genotypes of Urochloa …
Heterogeneous Impacts For Malaria Control From Larviciding Across Villages And Considerations For Monitoring And Evaluation, Ellie Sherrard-Smith, Ulrike Fillinger, Jean Philippe B. Tia, Peter Winskill, Benjamin G. Koudou, Emile S.F. Tchicaya, Antoine Sanou, Fredros Okumu, Mercy Opiyo, Silas Majambere, Arran Hamlet, Giovanni Charles, Ben Lambert, Thomas S. Churcher
Heterogeneous Impacts For Malaria Control From Larviciding Across Villages And Considerations For Monitoring And Evaluation, Ellie Sherrard-Smith, Ulrike Fillinger, Jean Philippe B. Tia, Peter Winskill, Benjamin G. Koudou, Emile S.F. Tchicaya, Antoine Sanou, Fredros Okumu, Mercy Opiyo, Silas Majambere, Arran Hamlet, Giovanni Charles, Ben Lambert, Thomas S. Churcher
All Peer-Reviewed Publications
Malaria vector control tools currently focus on insecticide treated nets (ITNs) and indoor residual spraying in malaria-endemic locations, but additional preventative strategies are needed to address protection gaps. Larval source management (LSM) includes larvicide application to aquatic habitat and an array of alternative forms of environmental efforts. An individual-based transmission model for falciparum malaria is used to demonstrate the theoretical benefit of suppressing malaria adult mosquito vector densities through LSM. The model simulates results of epidemiological trials from Western Kenya (a hilly area with papyrus swamps adjacent to human settlements and moderate to high perennial malaria transmission) and Côte d’Ivoire …
Meeting Report On An Integrated Research Agenda For Mosquito-Borne Arboviruses, Angela K. Ulrich, Nicolina M. Moua, Alison Mack, Natsuko Imai-Eaton, J. Erin Staples, Angela J. Mehr, Julia T. Ostrowsky, Tabitha Leighton, Ana Cehovin, Petra C. Fay, Josephine P. Golding, Emma Maynard, Luke Alphey, Diana P. Rojas Alvarez, Lark L. Coffey, Nuno R. Faria, Rafael Maciel-De-Freitas, Kevin Maringer, Kris A. Murray, Henrik Salje, Rosemary Sang, Pedro F.C. Vasconcelos, Yee Sin Leo, Steven P. Sinkins, Jocelyne Neto De Vasconcelos, Samuel K. Dadzie, Eva Harris, Thais H. Dos Santos, Raman Velayudhan
Meeting Report On An Integrated Research Agenda For Mosquito-Borne Arboviruses, Angela K. Ulrich, Nicolina M. Moua, Alison Mack, Natsuko Imai-Eaton, J. Erin Staples, Angela J. Mehr, Julia T. Ostrowsky, Tabitha Leighton, Ana Cehovin, Petra C. Fay, Josephine P. Golding, Emma Maynard, Luke Alphey, Diana P. Rojas Alvarez, Lark L. Coffey, Nuno R. Faria, Rafael Maciel-De-Freitas, Kevin Maringer, Kris A. Murray, Henrik Salje, Rosemary Sang, Pedro F.C. Vasconcelos, Yee Sin Leo, Steven P. Sinkins, Jocelyne Neto De Vasconcelos, Samuel K. Dadzie, Eva Harris, Thais H. Dos Santos, Raman Velayudhan
All Peer-Reviewed Publications
The emergence and re-emergence of mosquito-borne arbovirus (MBV) diseases pose a rapidly expanding global health threat fueled by the convergence of multiple ecologic, economic, and social factors, including climate change, land use, poverty, deficiencies of water storage and sanitation, and limitations of vector control programs. On December 6, 2023, the Wellcome Trust and the University of Minnesota's Center for Infectious Disease Research and Policy held a meeting titled "An integrated approach to mosquito-borne arboviruses: a priority research agenda."The meeting comprised presentations, panels, and facilitated discussions aimed at describing the state of the field, highlighting recent accomplishments, identifying novel strategies, and …
Long Akap18 Isoforms Anchor Ubiquitin Specific Proteinases And Coordinate Calcium Reuptake At The Sarcoplasmic Reticulum, Taeyeop Park, Katherine Forbush, Yong Li, Oscar Vivas, Kacey J Rosenthal, Jerome Falcone, Cassandra J Wong, James E Bruce, Claudia Moreno, Carmen W Dessauer, John D Scott
Long Akap18 Isoforms Anchor Ubiquitin Specific Proteinases And Coordinate Calcium Reuptake At The Sarcoplasmic Reticulum, Taeyeop Park, Katherine Forbush, Yong Li, Oscar Vivas, Kacey J Rosenthal, Jerome Falcone, Cassandra J Wong, James E Bruce, Claudia Moreno, Carmen W Dessauer, John D Scott
Faculty, Staff and Student Publications
Subcellular targeting of signaling enzymes influences where and when various modes of intracellular communication operate. Macromolecular complexes of signal transduction and signal termination elements favor reversible control of repetitive processes. This includes adrenergic stimulation of excitation–contraction coupling in the heart. Long isoforms of A-kinase anchoring protein 18 (AKAP18γ and δ) modulate this process via regulation of calcium uptake into the sarcoplasmic reticulum through the Ca2+ATPase 2a (SERCA2a). AKAP18 proximity-proteomic screening in cardiomyocytes identifies networks for protein kinase A (PKA) and ubiquitin-specific proteinases (USPs). A 2′phosphoesterase domain on AKAP18 interfaces with the USP4 isoform at the Z bands of sarcomeres. PKA …
Bridging Cell Morphological Behaviors And Molecular Dynamics In Multi-Modal Spatial Omics With Morphlink, Jing Huang, Chenyang Yuan, Jiahui Jiang, Jianfeng Chen, Sunil S Badve, Yesim Gokmen-Polar, Rossana L Segura, Xinmiao Yan, Alexander Lazar, Jianjun Gao, Bing Yao, Michael Epstein, Linghua Wang, Jian Hu
Bridging Cell Morphological Behaviors And Molecular Dynamics In Multi-Modal Spatial Omics With Morphlink, Jing Huang, Chenyang Yuan, Jiahui Jiang, Jianfeng Chen, Sunil S Badve, Yesim Gokmen-Polar, Rossana L Segura, Xinmiao Yan, Alexander Lazar, Jianjun Gao, Bing Yao, Michael Epstein, Linghua Wang, Jian Hu
Faculty, Staff and Student Publications
Multi-modal spatial omics data are invaluable for exploring complex cellular behaviors in diseases from both morphological and molecular perspectives. Current analytical methods primarily focus on clustering and classification, and do not adequately examine the relationship between cell morphology and molecular dynamics. Here, we present MorphLink, a framework designed to systematically identify disease-related morphological-molecular interplays. MorphLink has been evaluated across a wide array of datasets, showcasing its effectiveness in extracting and linking interpretable morphological features with various molecular measurements in spatial omics analyses. These linkages provide a transparent view of cellular behavior heterogeneity within tissue regions with similar cell type compositions, …