Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 161881 - 161910 of 5207295

Full-Text Articles in Entire DC Network

The Perception Of Neurofeedback Therapy In Improving Sleep Quality And Reducing Nightmares In Women With Ptsd, Amber Nicole Garcia Roper Aug 2025

The Perception Of Neurofeedback Therapy In Improving Sleep Quality And Reducing Nightmares In Women With Ptsd, Amber Nicole Garcia Roper

Doctoral Dissertations and Projects

This qualitative research investigation sought to examine the lived experiences of women diagnosed with Post-Traumatic Stress Disorder (PTSD) undergoing neurofeedback therapy with a concentrated emphasis on sleep quality and nightmares. Sleep disturbances are very common in individuals affected by PTSD and sleep disturbances make a remarkable impact on the broader mental health dimensions. Neurofeedback therapy, an emerging type of brainwave therapy, claims to play a promising role in dealing with these issues. Following this approach to phenomenology, putting greater emphasis on the subjective experiences of participants, this study establishes an understanding of how neurofeedback therapy influences sleep quality and the …


Prediction-Powered Inference For Clinical Trials: Application To Linear Covariate Adjustment, Pierre-Emmanuel Poulet, Maylis Tran, Sophie Tezenas Du Montcel, Bruno Dubois, Stanley Durrleman, Bruno M. Jedynak Aug 2025

Prediction-Powered Inference For Clinical Trials: Application To Linear Covariate Adjustment, Pierre-Emmanuel Poulet, Maylis Tran, Sophie Tezenas Du Montcel, Bruno Dubois, Stanley Durrleman, Bruno M. Jedynak

Mathematics and Statistics Faculty Publications and Presentations

Prediction-powered inference (PPI) (Angelopoulos et al., Science 382(6671):669-674, 2023) and its subsequent development called PPI++ (Angelopoulos et al., 2023) provide a novel approach to standard statistical estimation, leveraging machine learning systems, to enhance unlabeled data with predictions. We use this paradigm in clinical trials. The predictions are provided by disease progression models, providing prognostic scores for all the participants as a function of baseline covariates. The proposed method would empower clinical trials by providing untreated digital twins of the treated patients while remaining statistically valid. The potential implications of this new estimator of the treatment effect in a two-arm randomized …


Hurricane Katrina Archive: E-Books And E-Journals A To Z Bibliography 2020-2025, Lsu Health Sciences Center - New Orleans Libraries, Elizabeth H. Holt Aug 2025

Hurricane Katrina Archive: E-Books And E-Journals A To Z Bibliography 2020-2025, Lsu Health Sciences Center - New Orleans Libraries, Elizabeth H. Holt

LSUHSC Hurricane Katrina Archive: Bibliographies

This bibliography includes 43 electronic books and edited collections created on the topic of Hurricane Katrina by authors and others affiliated with LSU Health Sciences Center - New Orleans between September 2005 and August 2025.


Hurricane Katrina Archive: Faculty Publications Bibliography 2020-2025, Lsu Health Sciences Center - New Orleans Libraries, Sharon Duffy, Matthew Folse Aug 2025

Hurricane Katrina Archive: Faculty Publications Bibliography 2020-2025, Lsu Health Sciences Center - New Orleans Libraries, Sharon Duffy, Matthew Folse

LSUHSC Hurricane Katrina Archive: Bibliographies

This bibliography includes 10 articles about Hurricane Katrina written by authors affiliated with LSU Health – New Orleans between January 2020 and August 2025.


Hurricane Katrina Archive: Faculty Publications Bibliography 2015-2019, Lsu Health Sciences Center - New Orleans Libraries, Sharon Duffy, Matthew Folse Aug 2025

Hurricane Katrina Archive: Faculty Publications Bibliography 2015-2019, Lsu Health Sciences Center - New Orleans Libraries, Sharon Duffy, Matthew Folse

LSUHSC Hurricane Katrina Archive: Bibliographies

This bibliography includes 19 articles about Hurricane Katrina written by authors affiliated with LSU Health – New Orleans between January 2015 and December 2019.


Hurricane Katrina Archive: Libraries Catalog Bibliography, Lsu Health Sciences Center - New Orleans Libraries, Elizabeth H. Holt Aug 2025

Hurricane Katrina Archive: Libraries Catalog Bibliography, Lsu Health Sciences Center - New Orleans Libraries, Elizabeth H. Holt

LSUHSC Hurricane Katrina Archive: Bibliographies

This bibliography includes 15 books, videos, and edited collections created on the topic of Hurricane Katrina by authors and others affiliated with LSU Health Sciences Center - New Orleans between September 2005 and August 2025.


Hurricane Katrina Archive: Faculty Publications Bibliography 2010-2014, Lsu Health Sciences Center - New Orleans Libraries, Sharon Duffy, Matthew Folse Aug 2025

Hurricane Katrina Archive: Faculty Publications Bibliography 2010-2014, Lsu Health Sciences Center - New Orleans Libraries, Sharon Duffy, Matthew Folse

LSUHSC Hurricane Katrina Archive: Bibliographies

This bibliography includes 45 articles about Hurricane Katrina written by authors affiliated with LSU Health – New Orleans between January 2010 and December 2014.


Hurricane Katrina Archive: Faculty Publications Bibliography 2005-2009, Lsu Health Sciences Center - New Orleans Libraries, Sharon Duffy, Matthew Folse Aug 2025

Hurricane Katrina Archive: Faculty Publications Bibliography 2005-2009, Lsu Health Sciences Center - New Orleans Libraries, Sharon Duffy, Matthew Folse

LSUHSC Hurricane Katrina Archive: Bibliographies

This bibliography includes 91 articles about Hurricane Katrina written by authors affiliated with LSU Health – New Orleans between January 2005 and December 2009.


Approximation And Parameterized Algorithms For Covering With Disks Of Two Types Of Radii, Sayan Bandyapadhyay, Eli Mitchell Aug 2025

Approximation And Parameterized Algorithms For Covering With Disks Of Two Types Of Radii, Sayan Bandyapadhyay, Eli Mitchell

Computer Science Faculty Publications and Presentations

We study the Discrete Covering with Two Types of Radii problem motivated by its application in wireless networks. In this problem, the goal is to assign either small-range high frequency or large-range low frequency to each access point, maximizing the number of users in high-frequency regions while ensuring that each user is in the range of an access point. Unlike other weighted covering problems, our problem requires satisfying two simultaneous objectives, which calls for novel approaches that leverage the underlying geometry of the problem. In our work, we present two new algorithms: the first is a polynomial-time (2.5 + ϵ)-approximation, …


2025-2026 Performance Forum - August 29, 2025, Ziling Wang, Ian Lewis, Adolfo Ferrin Garcia Montañés, Nabil Hetman, Juan Diaz Quijano, Sheng Yuan Kuan, Patrick Hengstler, Kade Gordon, Dj Combs, Devin Foster Aug 2025

2025-2026 Performance Forum - August 29, 2025, Ziling Wang, Ian Lewis, Adolfo Ferrin Garcia Montañés, Nabil Hetman, Juan Diaz Quijano, Sheng Yuan Kuan, Patrick Hengstler, Kade Gordon, Dj Combs, Devin Foster

Performance Forum

No abstract provided.


Enhancing Reliable And Energy-Efficient Uav Communications With Ris And Deep Reinforcement Learning, Wasim Ahmad, Umar Islam, Abdulkadhem A. Abdulkadhem, Babar Shah, Fernando Moreira, Ali Abbas Aug 2025

Enhancing Reliable And Energy-Efficient Uav Communications With Ris And Deep Reinforcement Learning, Wasim Ahmad, Umar Islam, Abdulkadhem A. Abdulkadhem, Babar Shah, Fernando Moreira, Ali Abbas

All Works

The rapid growth in wireless communication demands has led to a surge in research on technologies capable of enhancing communication reliability, coverage, and energy efficiency. Among these, uncrewed aerial vehicles (UAV) and reconfigurable intelligent surfaces (RIS) have emerged as promising solutions. Prior research on using deep reinforcement learning (DRL) to integrate RIS with UAV concentrated on enhancing signal quality and coverage, but it ignored the challenges caused by electromagnetic interference (EMI). This article introduces a novel framework addressing the challenges posed by EMI from Gallium nitride (GaN) power amplifiers in RIS-assisted UAV communication systems. By integrating DRL with quadrature phase …


Ddos Attack Detection In Edge-Iiot Digital Twin Environment Using Deep Learning Approach, Feras Al-Obeidat, Adnan Amin, Ahmed Shuhaiber, Inam Ul Haq Aug 2025

Ddos Attack Detection In Edge-Iiot Digital Twin Environment Using Deep Learning Approach, Feras Al-Obeidat, Adnan Amin, Ahmed Shuhaiber, Inam Ul Haq

All Works

The industrial Internet of Things (IIoT) and digital twins are redefining how digital models and physical systems interact. IIoT connects physical intelligence, and digital twins virtually represent their physical counterparts. With the rapid growth of Edge-IIoT, it is crucial to create security and privacy regulations to prevent vulnerabilities and threats (i.e., distributed denial of service (DDoS)). DDoS attacks use botnets to overload the target system with requests. In this study, we introduce a novel approach for detecting DDoS attacks in an Edge-IIoT digital twin-based generated dataset. The proposed approach is designed to retain already learned knowledge and easily adapt to …


Which Work Of Art Will Be Voted Into Uab's Permanent Collection?, Shannon Thomason Aug 2025

Which Work Of Art Will Be Voted Into Uab's Permanent Collection?, Shannon Thomason

Browse All News

No abstract provided.


Public Benefits Cliffs And Asset Limits Harm The Economic Mobility Of Young Adult Workers, Stephen Roll, Mathieu Despard, Guangli Zhang Aug 2025

Public Benefits Cliffs And Asset Limits Harm The Economic Mobility Of Young Adult Workers, Stephen Roll, Mathieu Despard, Guangli Zhang

Center for Social Development Research

At its best, the public benefits system in the United States helps families avoid poverty’s most severe effects while also giving them a hand up. But the system also can keep working families in poverty. Workers may want to earn more money, take better jobs, or save for the future, but doing so can raise their income above program limits, causing workers to lose the benefits they and their families need to survive. This is known as the benefits cliff. This brief draws upon data from the Workforce Economic Inclusion and Mobility survey to explore how benefits cliffs and related …


Has Regional Hospital Autonomy Achieved Its Goals? Lessons Learned From Indonesia: A Systematic Review, Masyitoh Basabih, Indriaswari Widhakuswara Aug 2025

Has Regional Hospital Autonomy Achieved Its Goals? Lessons Learned From Indonesia: A Systematic Review, Masyitoh Basabih, Indriaswari Widhakuswara

Kesmas

This study examined the impact of hospital autonomy implementation on the performance of regional public hospitals in Indonesia, particularly in terms of efficiency, effectiveness, and governance. A systematic review of 32 peer-reviewed studies published between June 12 and September 6, 2023, was conducted using Garba Rujukan Digital and Google Scholar, following PRISMA guidelines. Studies addressing financial performance, service outcomes, and challenges related to implementing autonomy were included. The findings indicated that while autonomy led to improvements in infrastructure, service types, visit volumes, and hospital revenues, it had only a marginal impact on improving key health performance outcomes, such as service …


Understanding User Needs In Health Crisis Risk Monitoring Information System Development: A Lesson From Tasikmalaya District, Indonesia, Arief Tarmansyah Iman, Hari Kusnanto, Ariani Arista Putri Pertiwi Aug 2025

Understanding User Needs In Health Crisis Risk Monitoring Information System Development: A Lesson From Tasikmalaya District, Indonesia, Arief Tarmansyah Iman, Hari Kusnanto, Ariani Arista Putri Pertiwi

Kesmas

A health crisis risk monitoring information system needs to be developed, especially during the pre-disaster phase; therefore, understanding the needs of prospective users is crucial. This study aimed to investigate the needs of potential users regarding the development of this system. This study employed a qualitative, exploratory approach to gather user needs from stakeholders through interviews (n = 7) and one focus group discussion (n = 12). The data were audio-recorded, transcribed verbatim, and then thematically analyzed using qualitative content analysis. The need for information was related to disaster preparedness and its preferred format. The system should be targeted, multiplatform, …


Experiences Of Elderly Living With Noncommunicable Diseases In Utilizing Health Services In Myanmar During The Covid-19 Pandemic, Nway Eint Chei, Kwanjai Amnatsatsue, Natkamol Chansatitporn, Ariya Bunngamchairat Aug 2025

Experiences Of Elderly Living With Noncommunicable Diseases In Utilizing Health Services In Myanmar During The Covid-19 Pandemic, Nway Eint Chei, Kwanjai Amnatsatsue, Natkamol Chansatitporn, Ariya Bunngamchairat

Kesmas

The COVID-19 pandemic and armed conflicts in Myanmar have intensified the challenges in accessing and utilizing health services, particularly for noncommunicable diseases (NCDs) among older adults. This qualitative study explored the experiences of the elderly with NCDs regarding health service accessibility and utilization in secure areas with fully operational health facilities by conducting in-depth interviews with 20 eligible older adults in Myanmar; data were analyzed using content analysis. Four key themes emerged: NCD service utilization patterns; unmet needs; preferences and hesitancy toward NCD services; and disparities, barriers, and opportunities. The findings revealed widespread underutilization of NCD services due to several …


Low Economic Level And The Risk Of Overweight Among Indonesian Junior And Senior High School Students, Ariyanto Nugroho, Purwo Setiyo Nugroho, Amarin Yudhana, Sri Sunarti Aug 2025

Low Economic Level And The Risk Of Overweight Among Indonesian Junior And Senior High School Students, Ariyanto Nugroho, Purwo Setiyo Nugroho, Amarin Yudhana, Sri Sunarti

Kesmas

Overweight and obesity among Indonesian adolescents have emerged as a pressing public health issue, reflecting global trends. This study examines the relationship between economic status and overweight prevalence among junior and senior high school students in Indonesia, using secondary data from the Global School-based Health Survey (GSHS). This study analyzed data from 9,977 students aged 11–18 years through a cross-sectional design and binary logistic regression, adjusting for dietary habits, physical activity, and sedentary behavior. Overall, 14.7% of students were overweight; the prevalence was notably higher among low-income students (27.4%) compared to high-income groups (14.2%). Students from lower economic backgrounds were …


Government Health Spending And Life Expectancy: Evidence From Cities And Districts In Indonesia, Kurnia Sari, Budi Hidayat, Amal Chalik Sjaaf, Mardiati Nadjib Aug 2025

Government Health Spending And Life Expectancy: Evidence From Cities And Districts In Indonesia, Kurnia Sari, Budi Hidayat, Amal Chalik Sjaaf, Mardiati Nadjib

Kesmas

Life expectancy is widely recognized as a fundamental indicator of population health, and its improvement is often linked to government health spending, particularly in decentralized health systems. This study aimed to investigate the relationship between local government health expenditures and life expectancy in decentralized Indonesia. Data from 492 cities and districts, spanning from 2015 to 2019, were analyzed using a two-way fixed effects regression model to control for time-invariant district characteristics and common temporal shocks. The findings indicated that a 10% increase per capita in government health expenditure was associated with a 0.01% increase in life expectancy. This association was …


Opportunities For Using Generative Ai For Malevolent Creativity Information Gathering And Idea Generation, Alexis D'Amato, Emma Theobald, Ares Boira-Lopez, Joel Elson, Samuel Hunter Aug 2025

Opportunities For Using Generative Ai For Malevolent Creativity Information Gathering And Idea Generation, Alexis D'Amato, Emma Theobald, Ares Boira-Lopez, Joel Elson, Samuel Hunter

Reports, Projects, and Research

The success of terrorist and extremist organizations is dependent on their ability to be creative and innovative (e.g., Gill et al., 2013; Ligon et al., 2018; Logan et al., 2020). That is, these organizations are inherently focused on causing harm to their targets in ways that are novel, thus undetectable from threat assessment efforts. Homeland Security Enterprise can establish novel countermeasures to mitigate threats by engaging in the same creative problem-solving process as the terrorist and extremist organizations (e.g., d’Amato & Hunter, 2023). One way to do this is by using the same tools nefarious actors engage with for idea …


Spectrum Analysis Of Thermally Driven Curvature Inversion In Strained Graphene Ripples For Energy Conversion Applications Via Molecular Dynamics, James M. Mangum, Md R. Kabir, Tamzeed B. Amin, Syed M. Rahman, Ashaduzzaman, Paul M. Thibado Aug 2025

Spectrum Analysis Of Thermally Driven Curvature Inversion In Strained Graphene Ripples For Energy Conversion Applications Via Molecular Dynamics, James M. Mangum, Md R. Kabir, Tamzeed B. Amin, Syed M. Rahman, Ashaduzzaman, Paul M. Thibado

Physics Faculty Publications and Presentations

The extraordinary mechanical flexibility, high electrical conductivity, and nanoscale instability of freestanding graphene make it an excellent candidate for vibration energy harvesting. When freestanding graphene is stretched taut and subject to external forces, it will vibrate like a drum head. Its vibrations occur at a fundamental frequency along with higher-order harmonics. Alternatively, when freestanding graphene is compressed, it will arch slightly out of the plane or buckle under the load. Remaining flat under compression would be energetically too costly compared to simple bond rotations. Buckling up or down, also known as ripple formation, naturally creates a bistable situation. When the …


Governance Of Polygenic Embryo Screening: A Qualitative Study On The Perspectives Of Clinicians And Patients, Jason Bach, Jonathan Frumovitz, Dorit Barlevy, Rémy A Furrer, Abigail Martinez, Ana Battaglino, Shai Carmi, Todd Lencz, Gabriel Lázaro-Muñoz, Stacey Pereira Aug 2025

Governance Of Polygenic Embryo Screening: A Qualitative Study On The Perspectives Of Clinicians And Patients, Jason Bach, Jonathan Frumovitz, Dorit Barlevy, Rémy A Furrer, Abigail Martinez, Ana Battaglino, Shai Carmi, Todd Lencz, Gabriel Lázaro-Muñoz, Stacey Pereira

Center for Medical Ethics and Health Policy Staff Publications

Objective: To investigate the perspectives of stakeholders on their attitudes toward potential regulation of polygenic embryo screening (PES), a new form of preimplantation genetic testing that is used to screen embryos for the genetic chances of developing medical conditions and nonmedical traits involving hundreds or thousands of genes.

Design: We conducted individual, semistructured interviews and analyzed transcripts using thematic analysis.

Subjects: Twenty-seven US-based reproductive endocrinology and infertility specialists and 26 patients who were currently undergoing in vitro fertilization or had within the past five years.

Main outcome measures: Repeating ideas and patterned responses were organized into themes and subthemes.

Results: …


Staged Reconstruction And Salvage Of A Small Finger With A Corticocancellous Distal Radius Autograft: A Case Report, Emmanuel Franco, Zayd Ayas, Frank Gerold Aug 2025

Staged Reconstruction And Salvage Of A Small Finger With A Corticocancellous Distal Radius Autograft: A Case Report, Emmanuel Franco, Zayd Ayas, Frank Gerold

School of Medicine Publications

Finger reconstruction in the aftermath of severe trauma poses significant challenges in restorative surgery, particularly when addressing extensive soft tissue damage, comminuted fractures, and simultaneous neurovascular complications. This study presents a case of a patient with a complicated proximal phalangeal fracture who pursued digit salvage.

A 31-year-old Hispanic woman sustained severe injury to her right fifth digit during an all-terrain vehicle (ATV) rollover resulting in an exposed, comminuted fracture of the proximal phalanx with extensive structural and neurovascular compromise. She pursued digit salvage despite a high risk of failure and complication. The patient underwent four operations over a six-month period, …


Symmetrically Threaded Superconducting Quantum Interference Devices As Next-Generation Kerr-Cat Qubits, Bibek Bhandari, Irwin Huang, Ahmed Hajr, Kagan Yanik, Bingcheng Qing, Ke Wang, David I. Santiago, Justin Dressel, Irfan Siddiqi, Andrew N. Jordan Aug 2025

Symmetrically Threaded Superconducting Quantum Interference Devices As Next-Generation Kerr-Cat Qubits, Bibek Bhandari, Irwin Huang, Ahmed Hajr, Kagan Yanik, Bingcheng Qing, Ke Wang, David I. Santiago, Justin Dressel, Irfan Siddiqi, Andrew N. Jordan

Mathematics, Physics, and Computer Science Faculty Articles and Research

Kerr-cat qubits are bosonic qubits offering autonomous bit-flip protection, traditionally studied using driven superconducting nonlinear asymmetric inductive element (SNAIL) oscillators. Here, we theoretically explore an alternative circuit for Kerr-cat qubits based on symmetrically threaded superconducting quantum interference devices (SQUIDs). The symmetrically threaded SQUID (STS) architecture employs a simplified flux-pumped design that suppresses two-photon dissipation, a dominant loss mechanism in high-Kerr regimes, by engineering the drive Hamiltonian’s flux operator to generate only even-order harmonics. By fulfilling two critical criteria for practical Kerr-cat qubit operation, the STS emerges as an ideal platform: (1) a static Hamiltonian with diluted Kerr nonlinearity (achieved via …


Ras-Membrane Interaction And Oligomerization: There Is More Than Meets The Eye, Abraham C Sianoya, Vijay K Bhardwaj, Alemayehu A Gorfe Aug 2025

Ras-Membrane Interaction And Oligomerization: There Is More Than Meets The Eye, Abraham C Sianoya, Vijay K Bhardwaj, Alemayehu A Gorfe

Faculty, Staff and Student Publications

Membrane association is fundamental to Rat sarcoma (RAS) function, driving both its physiologic signaling and oncogenic transformation. This review consolidates recent advances in the study of RAS-membrane interactions, emphasizing the molecular mechanisms underlying its membrane engagement and oligomerization. We first discuss the roles of RAS lipid modification and conformational diversity of its intrinsically disordered C-terminus in these processes, and we then examine the debate surrounding RAS dimerization and its potential role in the formation of higher-order oligomers. By integrating emerging insights into these issues, we offer our own perspectives on the driving forces of RAS oligomerization and propose potential new …


Risk Of Major Depression In Partners Of People With Alzheimer's Disease: A National Cohort Study, Casey Crump, Jingkai Wei, Barbara G Vickrey, Alexis C Edwards, Paul E Schulz, Jan Sundquist Aug 2025

Risk Of Major Depression In Partners Of People With Alzheimer's Disease: A National Cohort Study, Casey Crump, Jingkai Wei, Barbara G Vickrey, Alexis C Edwards, Paul E Schulz, Jan Sundquist

Faculty, Staff and Student Publications

Background: Alzheimer's disease (AD) may cause significant psychosocial distress not only in the patient but also their partner. However, long-term risks of major depression in partners of AD patients are largely unknown.

Methods: A national cohort study was conducted of all 145 289 partners of people diagnosed with all-cause dementia, including 57 113 partners of people diagnosed with AD, in Sweden during 1998-2017, and 1 300 561 population-based controls. Cox regression was used to compute hazard ratios (HRs) for subsequent risk of major depression identified from nationwide outpatient and inpatient diagnoses through 2018, adjusting for sociodemographic factors and prior mental …


Epigenetic Modulation Of Bard1 To Enhance Anti-Vegf Therapy, Emine Bayraktar, Cristian Rodriguez-Aguayo, Elaine Stur, Sudhir Kumar, Lingegowda S Mangala, Nazende Nur Bayram, Amma Asare, Cristina Ivan, Mark S Kim, Thanh Chung Vu, Pahul Hanjra, Sangbae Kim, Adrian Lankenau Ahumada, Weichem Wu, Sanghoon Lee, Anna Szymanowska, Hulya Oztatlici, Marcos R Estecio, Ju-Seog Lee, Abhinav K Jain, Nidhi Sahni, John P Hagan, Stephen Baylin, Jinsong Liu, Gabriel Lopez-Berestein, Sunila Pradeep, Anil K Sood Aug 2025

Epigenetic Modulation Of Bard1 To Enhance Anti-Vegf Therapy, Emine Bayraktar, Cristian Rodriguez-Aguayo, Elaine Stur, Sudhir Kumar, Lingegowda S Mangala, Nazende Nur Bayram, Amma Asare, Cristina Ivan, Mark S Kim, Thanh Chung Vu, Pahul Hanjra, Sangbae Kim, Adrian Lankenau Ahumada, Weichem Wu, Sanghoon Lee, Anna Szymanowska, Hulya Oztatlici, Marcos R Estecio, Ju-Seog Lee, Abhinav K Jain, Nidhi Sahni, John P Hagan, Stephen Baylin, Jinsong Liu, Gabriel Lopez-Berestein, Sunila Pradeep, Anil K Sood

Faculty, Staff and Student Publications

Despite the clinical use of anti-vascular endothelial growth factor (VEGF) antibodies (AVAs) in cancer therapy, resistance frequently develops, leading to disease progression. To address this, we identify a previously unknown role for breast cancer type 1 susceptibility protein (BRCA1)-associated RING domain 1 (BARD1) in modulating AVA sensitivity. Epigenetic modulation-via global and targeted DNA methylation-reveals BARD1 as a key regulator of angiogenesis. Sequential treatment with azacytidine overcomes AVA resistance in vivo. To enable precise epigenetic reactivation, we develop a liposomal CRISPR-deactivated Cas9 (dCas9)-TET1 system guided by BARD1-targeting single-guide RNAs (sgRNAs). This platform achieves CpG-specific demethylation of the BARD1 promoter, restores expression, …


The After Effects Of The Covid-19 Pandemic On The Mental Health Of International V/S Domestic Students - A Qualitative Study, Keerat Sidhu Bhatti Aug 2025

The After Effects Of The Covid-19 Pandemic On The Mental Health Of International V/S Domestic Students - A Qualitative Study, Keerat Sidhu Bhatti

Doctoral Dissertations

The COVID-19 pandemic significantly impacted the mental health of both international and domestic graduate students, exacerbating social isolation, financial strain, and psychological distress. This qualitative study examines the long-term effects of the pandemic on these student populations, exploring shared and divergent experiences, coping strategies, and evolving priorities. While both groups faced heightened anxiety and academic disruptions, international students encountered additional stressors, including cultural displacement, visa uncertainties, and limited support networks. Domestic students, in contrast, struggled with routine disruptions but had greater access to familial and social support. Across both groups, the pandemic prompted a reassessment of personal and professional priorities, …


Excitotoxic Neuronal Death Requires Superoxide Entry Into Neurons Through Volume-Regulated Anion Channels, Kate Harris, Seok Joon Won, Gokhan Uruk, Nguyen Mai, Devran Ogut, Yonghui Zhao, Litao Xie, Paul Baxter, Katharina Everaerts, Rajan Sah, Raymond A Swanson Aug 2025

Excitotoxic Neuronal Death Requires Superoxide Entry Into Neurons Through Volume-Regulated Anion Channels, Kate Harris, Seok Joon Won, Gokhan Uruk, Nguyen Mai, Devran Ogut, Yonghui Zhao, Litao Xie, Paul Baxter, Katharina Everaerts, Rajan Sah, Raymond A Swanson

2020-Current year OA Pubs

Neuronal death in stroke and other conditions stems in part from stimulation of


Prefoldin Complex Promotes Interferon-Stimulated Gene Expression And Is Inhibited By Rotavirus Vp3, Yinxing Zhu, Yanhua Song, Dilip Kumar, Peter K Jackson, B V Venkataram Prasad, Siyuan Ding Aug 2025

Prefoldin Complex Promotes Interferon-Stimulated Gene Expression And Is Inhibited By Rotavirus Vp3, Yinxing Zhu, Yanhua Song, Dilip Kumar, Peter K Jackson, B V Venkataram Prasad, Siyuan Ding

2020-Current year OA Pubs

Timely induction of interferons and interferon-stimulated genes (ISGs) is critical for successful host defense against viral infections. VP3 encoded by rotavirus is implicated in interferon antagonism. However, the precise mechanisms remain incompletely understood. By conducting tandem-affinity purification coupled with high-resolution mass spectrometry, we identify the prefoldin complex as the top cellular binding partner of VP3. Rotavirus infection is significantly enhanced in prefoldin subunit knockout cells. Using proteome-wide label-free quantification, we find that prefoldin assists in folding ubiquitin-like-modifier-activating-enzyme-3 (UBA3), both of which positively regulate ISG expression. Through direct and competitive binding, VP3 interferes with the chaperone activity of prefoldin, leading to …