Digital Commons Network^™

Phosphorylation Toggles The Sars-Cov-2 Nucleocapsid Protein Between Two Membrane-Associated Condensate States, Bruna Favetta, Huan Wang, Jasmine Cubuk, Arjun Singh, Mayur Barai, Cesar Ramirez, Haiyan Zheng, Adam J Gormley, N Sanjeeva Murthy, Gregory Dignon, Andrea Soranno, Zheng Shi, Benjamin S Schuster

2020-Current year OA Pubs

The Nucleocapsid protein (N) of SARS-CoV-2 plays a critical role in the viral lifecycle by regulating RNA replication and by packaging the viral genome. N and RNA phase separate to form condensates that may be important for these functions. Both functions occur at membrane surfaces, but how N toggles between these two membrane-associated functional states is unclear. Here, we reveal that phosphorylation switches how N condensates interact with membranes, in part by modulating condensate material properties. Our studies also show that phosphorylation alters N's interaction with viral membrane proteins. We gain mechanistic insight through structural analysis and molecular simulations, which …

Defrnd: Detergent-Free Reconstitution Into Native Nanodiscs With Designer Membrane Scaffold Peptides, Qian Ren, Vinay Idikuda, Baron Chanda, Et Al.

2020-Current year OA Pubs

Membrane scaffold protein-based nanodiscs have facilitated unprecedented structural and biophysical analysis of membrane proteins in a near-native lipid environment. However, successful reconstitution of membrane proteins in nanodiscs requires prior solubilization and purification in detergents, which may impact their physiological structure and function. Furthermore, the detergent-mediated reconstitution of nanodiscs is unlikely to recapitulate the precise composition or asymmetry of native membranes. To circumvent this fundamental limitation of traditional nanodisc technology, we herein describe the development of membrane-solubilizing peptides to directly extract membrane proteins from native cell membranes into nanoscale discoids. By systematically protein engineering and screening, we create a class of …

Danicamtiv Reduces Myosin's Working Stroke But Activates The Thin Filament By Accelerating Actomyosin Attachment, Brent Scott, Lina Greenberg, Caterina Squarci, Kenneth S Campbell, Michael J Greenberg

2020-Current year OA Pubs

Heart failure is a leading cause of death worldwide, and even with current treatments, the 5-y transplant-free survival rate is only ~50 to 70%. As such, there is a need to develop new treatments for patients that improve survival and quality of life. Recently, there have been efforts to develop small molecules for heart failure that directly target components of the sarcomere, including cardiac myosin. Danicamtiv is one of these molecules; however, its direct effects on myosin's single molecule mechanics and kinetics are not well understood. Using optical trapping techniques, stopped flow transient kinetics, and in vitro reconstitution assays, we …

A Gift Of Art And History, Stephanie Shreffler

Marian Library Blog Archive

The world's foremost collector of works by the Italian illustrator Ezio Anichini has donated his collection to the Marian Library, which featured the works in a 2022 exhibit.

Resistance And Adaptation: How Religion Survived A War, Iris Mascio

History Theses, Dissertations, and Student Creative Activity

This paper investigates the survival strategies employed by Bosnian Muslims during the civil wars of the 1990s, with a focus on how these strategies influenced the practice and evolution of Bosnian Islam. Drawing on primary and secondary sources, survivor interviews, and analyses of religious and social practices, the study identifies two key modes of response: adaptation and resistance. While resistance—including underground organizing, covert publications, and occasional armed defense—played a role during periods of extreme threat, it was primarily historical patterns of adaptation that enabled long-term survival and continuity. Therefore, the paper covers the challenges encountered and survival strategies used by …

Danicamtiv Reduces Myosin’S Working Stroke But Activates The Thin Filament By Accelerating Actomyosin Attachment, Brent Scott, Lina Greenberg, Caterina Squarci, Kenneth S. Campbell, Michael J. Greenberg

Physiology Faculty Publications

Heart failure is a leading cause of death worldwide, and even with current treatments, the 5-y transplant-free survival rate is only ~50 to 70%. As such, there is a need to develop new treatments for patients that improve survival and quality of life. Recently, there have been efforts to develop small molecules for heart failure that directly target components of the sarcomere, including cardiac myosin. Danicamtiv is one of these molecules; however, its direct effects on myosin’s single molecule mechanics and kinetics are not well understood. Using optical trapping techniques, stopped flow transient kinetics, and in vitro reconstitution assays, we …

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Extension Partnership Saluted As Osborne Farm Celebrates 250 Years In The Family, Keith Testa

UNH Today Archive

No abstract provided.

Law School News : A New Class Of Changemakers : Record-Breaking Class Of 2028 Begins Legal Education 08-26-2025, Suzi Morales

Life of the Law School (1993- )

No abstract provided.

Data For Recreation Effects On Soil Carbon, Biocrust, Soil Stability, And Invasives In Indian Creek, Bears Ears National Monument, Elisabeth M. Currit, Tara B. Bishop, April Hulet, Nathan Allen Currit, Teresa Gomez, Nathan T. Thompson, Shannon Lambson, Heidi Jean Wilding Mann, Evan Miller, Erin Jones, Alexandra Olson, Katherine A. Anselmi, Meredith Murdock, Ella Reid, Kirsten Steele, Indy Lawrence, Neil Hansen

ScholarsArchive Data

This data is about how different types of recreation impact different soil and vegetation properties related to soil carbon in Indian Creek, Bears Ears National Monument. The data was collected from May 2023 to October 2023. It contains plant functional group cover, biocrust cover and type, soil stability, and compaction data for each individual site. There are 5-7 of each site type: camping, foot trails, and motorized offroading trails, and undisturbed sites, with a total of 30 sites. It also contains the code used to analyze the raw data and the figures created.

State Of New Jersey Cannabis Testing, University Of Mississippi – National Center For Cannabis Research And Education, Yasha Kahn, Mcr Labs

New Jersey

No abstract provided.

August 26, 2025 Nagpra And Tribal Relations Committee Meeting Minutes, Bryan Morey

University NAGPRA and Tribal Relations Committee

August 26, 2025 minutes for the WKU NAGPRA and Tribal Relations Committee meeting. Meeting conducted via Zoom.

Indifferentiability Analysis Of Symmetric Key Ciphers, Sayantan Paul

Doctoral Theses

The thesis presented here analyses the security of certain selected symmetric key ciphers - The ciphers analyzed are the 2 and 3-round Confusion-Diffusion Network, the 3-round Cascade Cipher with two independent keys, and the Feistel Construction with 7 and 8 rounds. Substitution Permutation Networks (SPNs) are widely used in the design of modern symmetric cryptographic building blocks. Attacks against the 2-round Confusion-Diffusion Network construction have been exhibited by Dodis et al. (2016a) in their Eurocrypt 2016 paper titled ‘Indifferentiability of Confusion-Diffusion Networks’, and by Da, Xu and Guo (2021b) in their paper ‘Sequential Indifferentiability of Confusion-Diffusion Networks’. Both attacks mentioned …

Hourly Simulated Power Production Data With No Snow Loss Model At Queued Utility-Scale Pv Sites Simulated As Single-Axis Tracking Systems In The U.S. Eastern Interconnection For Weather Year 2019, Shelbie Wickett, Ana Dyreson

Simulated Solar Capacity Including Snow Cover in the Eastern U.S.

Using 2019 weather data, we ran PySAM power production simulations for utility-scale PV sites in the U.S. Eastern Interconnection queue. Site IDs, capacities, and locations (counties) were extracted from Lawrence Berkeley National Laboratory's Queued Up: 2024 Edition dataset. No panel mount information was provided, so all sites were assumed to be the centers of the installation counties. See queued_site_metadata.csv file for individual site metadata

Pursuing Life-Giving Creativity, Donald Roth

Faculty Work Comprehensive List

"In studying creativity, I’ve found that it’s often more about the types of questions we ask than waiting for inspiration to strike."

Posting about innovation from In All Things, an online hub that offers insight into maintaining and faithful and orthodox Reformed Christian worldview while fearlessly engaging in every aspect of contemporary life – until all is made new.

Pursuing Life-Giving Creativity

Anionic Azo Dyes: Wastewater Pollutants As Functionalizing Agents For Porous Polycarbonate Membranes Aiding In Water Decolorization, Alan Jarrett Messinger, Isabella S. Mays, Brennon Craigo, Jeffrey Joering, Sean P. Mcbride

Physics Faculty Research

Efficient water decolorization techniques are vital for ensuring fresh water for future generations. Azo dyes are used heavily in the textile industry and are a challenge to remove from industrial wastewater. This research expands on recent innovative work where anionic azo dyes themselves were used to functionalize track-etched porous polycarbonate filtration membranes with decolorized water obtained as a byproduct. The objective of this research is to determine whether the observed dye rejection is dependent on the magnitude of the intrinsic charge of the dye molecule or on its structure, using two selectively chosen anionic azo dye series during functionalization. The …

Exploring The Moderating Effect Of Boundary Management Strategy In A Remote Work Environment, Brandon M. Vasquez

Master's Theses

Remote work has evolved significantly, especially during the COVID-19 pandemic, and continues to influence employee experiences in both positive and negative ways. Managing the separation between work and personal life is of importance. More specifically, using a boundary management strategy of segmentation may be more effective than an integration strategy because those who separate the two domains of work and family/personal life may be less prone to conflict in their lives. The present study aimed to examine the moderating effect of boundary management strategy on the relationship between remote work and job satisfaction, work-life balance, and well-being. Specifically, it was …

Effects Of Cryoprotective And Mitochondrial Stabilizing Agents On Vitrified Bovine Oocytes, Allison Hoang

LSU Master's Theses

Oocyte vitrification success is highly dependent on cryoprotectant agent (CPA) choice as well as possible additives that could help preserve mitochondrial membrane potential (mMP), reactive oxygen species (ROS) production, and calcium homeostasis within the cell. It is a delicate balance between levels needed for proper oocyte function and activation and levels needed to induce apoptotic pathways. The results of oocyte cryopreservation determine the eventual oocyte viability and subsequent fertilization and embryo development.

In this study potential permeating cryoprotectant combinations were explored such as ethylene glycol (EG) and propylene glycol (PG) or EG in combination with dimethyl sulfoxide (DMSO). Also, the …

Exploring The Service-Learning Volunteer Experience Of African American Male Educators In Urban Schools, Gia N. Paige

Walden Dissertations and Doctoral Studies

Educators who self-identify as African American male educators are underrepresented in educational leadership and scholarship on service learning, despite the significant roles they play in shaping urban educational spaces. In this qualitative phenomenological study, the lived service experiences of five African American male educators who engaged in service-learning and volunteerism in urban schools were explored. The purpose was to examine how these educators narrated their service experiences and how those experiences intersected with their identity as African American males. African American male theory was used to frame the study, emphasizing cultural heritage, resistance to deficit perspectives, and the affirmation of …

Staff Education To Enhance Nursing Knowledge And Confidence In Withdrawal Management Using The Clinical Institute Withdrawal Assessment And Clinical Opiate Withdrawal Scale, Margaret Sarana Hector

Walden Dissertations and Doctoral Studies

This quality improvement staff education project addressed the inconsistent use of the Clinical Institute Withdrawal Assessment (CIWA) and Clinical Opiate Withdrawal Scale (COWS) assessment tools among nursing staff in an adult psychiatric and addictions unit located in the Mid-Atlantic region of the United States. Inconsistent use of the CIWA and COWS tools may lead to unfavorable patient outcomes. The goal of this project was to enhance nursing familiarity, confidence, and sense of importance in using CIWA and COWS tools for assessing and managing withdrawal symptoms in patients with co-occurring depression and substance use disorders. A pre- and posteducation survey design …

Employees’ Perceptions Of Their Performance Based On Continuous Training In Hospitals, Mohamad El Fakih

Walden Dissertations and Doctoral Studies

Training perceived as irrelevant or insufficient may lead to disengagement, lower performance, and even burnout, particularly in high-stress healthcare environments. The specific research problem is that Lebanese hospitals fail to adopt tailored training strategies that effectively enhance healthcare workers’ perceptions of their performance. The purpose of this qualitative interpretive phenomenological study was to explore the lived experiences of hospital employees in Lebanon, focusing on how ongoing training influenced their perceived job performance. Social learning theory, organizational learning theory, and institutional theory grounded this study. The participants comprised nine hospital administrators in Beirut. Data were collected using in-depth, semistructured interviews. Ten …

The Problem Of Market Power In Postwar America: Antitrust Law, Regulatory Discourse, And Changing Ideas Of Market Power, Laura Phillips-Sawyer

Scholarly Works

US antitrust law prohibits anticompetitive restraints of trade, including collusion among firms and single-firm monopolization. The law serves as a democratic check against concentrations of private economic power. However, in the post-World War II era, the law has changed largely through case law, rather than through statutory interventions. Thus, understanding the role that antitrust law has played in reconciling capitalism and democracy requires us to ask what has influenced changes to antitrust law. This chapter traces antitrust law’s postwar development across three key periods: 1940–1970s, mid-1970s to 2010s, and 2010s to present. It argues that each era’s approach to the …

Segmental Atrophy Of The Liver: Review Of A Rare Pseudotumor, Ayesha Younus, Yu Liu, Ellen E. Connor, Zeng-Ying Wu, Hwajeong Lee, Zhi-Yan Fu

School of Medicine Faculty Publications

Segmental atrophy (SA) of the liver is a rare, often underrecognized, benign condition that presents as a mass lesion, mimicking a neoplasm, which poses a significant diagnostic challenge. Given its rarity, only a limited number of case reports and series have been published, resulting in sparse literature on the entity. This review aims to summarize the clinicopathologic and diagnostic features of SA and thus improve its recognition.

Quantum Error Correction: Studying Correlated Errors On Surface Codes, Reu/Fri Program Physics And Astronomy, Pritesh Thakur

Student Works

No abstract provided.

Tabletop Isotropic Source For Neutron Science Training Poster, Reu/Fri Program Physics And Astronomy, Jarom Peterson

Student Works

To develop affordable tabletop neutron sources for neutron science research and education, GS20 scintillator glass doped with Americium-241 is being evaluated inside the BYU Isotropic Fission Chamber (IFC). Our 1985 sample was assessed for radiation damage and found to be in good condition. Neutrons from Am-241 interactions were optically flagged and observed using the IFC in conjunction with the LGB-PVT Neutron Pseudo Spectrometer Detector. Data was recorded via a CAEN desktop digitizer. The analysis code continues to be developed, and the neutron detector will be calibrated using deuterium-deuterium (DD) interactions in the future.

The Atmospheric Characterization Of Abnormally Blue Early T-Dwarfs Midterm Presentation, Reu/Fri Program Physics And Astronomy, Madalyn Chapleski

Student Works

No abstract provided.

Murmurations Of Modular Forms And P-Power Coefficients, Debanjana Kundu, Katharina Müller

School of Mathematical & Statistical Sciences Faculty Publications

We extend the work of N. Zubrilina on murmuration of modular forms to the case when prime-indexed coefficients are replaced by squares of primes. Our key observation is that the shape of the murmuration density is the same.

Slc35g3 Is A Udp-N-Acetylglucosamine Transporter For Sperm Glycoprotein Formation And Underpins Male Fertility In Mice, Daisuke Mashiko, Shingo Tonai, Haruhiko Miyata, Martin M Matzuk, Masahito Ikawa

Faculty, Staff and Students Publications

Despite the recognized importance of glycans in biological phenomena, their complex roles in spermatogenesis and sperm function remain unclear. SLC35G3, a 10-transmembrane protein specifically found in early round spermatids, belongs to the sugar-nucleotide transporter family, indicating its involvement in glycan formation. In this study, we found that Slc35g3 knockout male mice were sterile due to impaired sperm functions in uterotubal junction passage, zona pellucida binding, and oocyte fusion. Mouse SLC35G3 has UDP-GlcNAc transporter activity, and its ablation caused abnormal processing of the sperm plasma membrane and acrosome membrane proteins. Reported human SLC35G3 mutations (F267L and T179HfsTer27) diminished the UDP-GlcNAc transporter …

Mrna Vaccines Encoding Variant Forms Of Sm-Tsp-2 Confer Protective Immunity Against Schistosoma Mansoni, Athos Silva Oliveira, Sevan Alwan, Philip T Loverde, Ramiz Shaheed, Pranav Mandyam, Rakesh Adhikari, Peter Hotez, Maria Elena Bottazzi, Jeroen Pollet

Faculty, Staff and Students Publications

Despite the global burden of helminth infections, no human vaccines have yet been licensed against these parasites. This study explored the development and evaluation of mRNA vaccine candidates targeting Schistosoma mansoni tetraspanin-2 (Sm-TSP-2), an antigen currently under evaluation as a protein vaccine. We designed constructs encoding either full-length Sm-TSP-2, or its large extracellular loop (EC2) domain in secretory, membrane-anchored, or cytosolic forms. In a murine challenge model, the secreted and membrane-anchored versions of Sm-TSP-2-EC2 induced the highest of antigen-specific antibody titers. These two construct designs, along with full-length Sm-TSP-2 mRNA, also significantly reduced adult worm …

Lindenwood Athletics Enters A New Era Of Play, Truman Griessel

Lindenlink (2012- )

No abstract provided.