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Utilization Of Colors, Lighting, And Materials As A Narrative Ai-Tool To Convey Human Emotions In Museums’ Interior Spaces. A Case Study Of The Museum Of Islamic Art Cairo, Egypt., Dalia Moati, Rawan Medhat, Fagr Hesham, Nada Khaled, Tamer Aug 2025

Utilization Of Colors, Lighting, And Materials As A Narrative Ai-Tool To Convey Human Emotions In Museums’ Interior Spaces. A Case Study Of The Museum Of Islamic Art Cairo, Egypt., Dalia Moati, Rawan Medhat, Fagr Hesham, Nada Khaled, Tamer

Architectural Engineering

This study explores the relationship between museum interior design and human emotional responses, focusing on how key design elements—color, lighting, and materials—can be optimized to enhance visitor engagement and emotional well- being. Conducted at the Museum of Islamic Art in Cairo, Egypt, the research examines two critical spaces along the visitor journey: the Medicine Hall, introducing the experience, and the Writings Hall, situated toward the end of the route, where fatigue and emotional disengagement often occur. Over a nine-week period, a mixed-methods approach was employed, integrating structured observation, behavioral mapping, and AI-assisted image modifications to generate controlled design variations, alongside …


Unh Launches Initiative To Improve Outcomes For Stem Ph.D. Students, Beth Potier Aug 2025

Unh Launches Initiative To Improve Outcomes For Stem Ph.D. Students, Beth Potier

UNH Today Archive

No abstract provided.


In Memoriam: Eric Lund, Rebecca Irelan Aug 2025

In Memoriam: Eric Lund, Rebecca Irelan

UNH Today Archive

No abstract provided.


The Research Behind New Hampshire’S Outdoor Recreational Experience, Aaron Sanborn Aug 2025

The Research Behind New Hampshire’S Outdoor Recreational Experience, Aaron Sanborn

UNH Today Archive

No abstract provided.


Machine Learning And Crime Prevention, Emily Lizewski Aug 2025

Machine Learning And Crime Prevention, Emily Lizewski

Student Theses

Predictive policing uses machine learning to analyze crime patterns and help law enforcement better efficient use their resources. These tools can improve accuracy by highlighting complex trends in large sets of data. While this technology has its advantages, it also raises important ethical and social questions. Within this paper we looks at how predictive policing works, focusing on the machine learning models often used such as decision trees, random forests, gradient boosting, and models that factor in both time and location. It also explores how these tools might unintentionally reinforce biases already present in historical crime data. In reviewing the …


Hourly Simulated Power Production Data With No Snow Loss Model At Queued Utility-Scale Pv Sites Simulated As Single-Axis Tracking Systems In The U.S. Eastern Interconnection For Weather Year 2016, Shelbie Wickett, Ana Dyreson Aug 2025

Hourly Simulated Power Production Data With No Snow Loss Model At Queued Utility-Scale Pv Sites Simulated As Single-Axis Tracking Systems In The U.S. Eastern Interconnection For Weather Year 2016, Shelbie Wickett, Ana Dyreson

Simulated Solar Capacity Including Snow Cover in the Eastern U.S.

Using 2016 weather data, we ran PySAM power production simulations for utility-scale PV sites in the U.S. Eastern Interconnection queue. Site IDs, capacities, and locations (counties) were extracted from Lawrence Berkeley National Laboratory's Queued Up: 2024 Edition dataset. No panel mount information was provided, so all sites were assumed to be the centers of the installation counties. See queued_site_metadata.csv file for individual site metadata


Hourly Simulated Power Production Data With No Snow Loss Model At Queued Utility-Scale Pv Sites Simulated As Single-Axis Tracking Systems In The U.S. Eastern Interconnection For Weather Year 2018, Shelbie Wickett, Ana Dyreson Aug 2025

Hourly Simulated Power Production Data With No Snow Loss Model At Queued Utility-Scale Pv Sites Simulated As Single-Axis Tracking Systems In The U.S. Eastern Interconnection For Weather Year 2018, Shelbie Wickett, Ana Dyreson

Simulated Solar Capacity Including Snow Cover in the Eastern U.S.

Using 2018 weather data, we ran PySAM power production simulations for utility-scale PV sites in the U.S. Eastern Interconnection queue. Site IDs, capacities, and locations (counties) were extracted from Lawrence Berkeley National Laboratory's Queued Up: 2024 Edition dataset. No panel mount information was provided, so all sites were assumed to be the centers of the installation counties. See queued_site_metadata.csv file for individual site metadata


Hourly Simulated Power Production Data With Snow Loss Model At Existing Utility-Scale Pv Sites (>5 Mw) In The U.S. Eastern Interconnection In 2013, Shelbie Wickett, Ana Dyreson Aug 2025

Hourly Simulated Power Production Data With Snow Loss Model At Existing Utility-Scale Pv Sites (>5 Mw) In The U.S. Eastern Interconnection In 2013, Shelbie Wickett, Ana Dyreson

Simulated Solar Capacity Including Snow Cover in the Eastern U.S.

Project Summary: We ran PySAM power production simulations for utility-scale (>5 MW) PV sites located in the U.S. Eastern Interconnection in the year 2013. Site panel mounts (fixed-tilt or single-axis tracking), capacities, and locations (latitudes and longitudes) were extracted from Lawrence Berkeley National Laboratory's Utility-Scale Solar 2024 Edition dataset. See 2013_PV_existing_site_metadata.csv file for individual site metadata.


Hourly Simulated Power Production Data With Snow Loss Model At Existing Utility-Scale Pv Sites (>5 Mw) In The U.S. Eastern Interconnection In 2014, Shelbie Wickett, Ana Dyreson Aug 2025

Hourly Simulated Power Production Data With Snow Loss Model At Existing Utility-Scale Pv Sites (>5 Mw) In The U.S. Eastern Interconnection In 2014, Shelbie Wickett, Ana Dyreson

Simulated Solar Capacity Including Snow Cover in the Eastern U.S.

Project Summary: We ran PySAM power production simulations for utility-scale (>5 MW) PV sites located in the U.S. Eastern Interconnection in the year 2014. Site panel mounts (fixed-tilt or single-axis tracking), capacities, and locations (latitudes and longitudes) were extracted from Lawrence Berkeley National Laboratory's Utility-Scale Solar 2024 Edition dataset. See 2014_PV_existing_site_metadata.csv file for individual site metadata.


Hourly Simulated Power Production Data With No Snow Loss Model At Existing Utility-Scale Pv Sites (>5 Mw) In The U.S. Eastern Interconnection In 2015, Shelbie Wickett, Ana Dyreson Aug 2025

Hourly Simulated Power Production Data With No Snow Loss Model At Existing Utility-Scale Pv Sites (>5 Mw) In The U.S. Eastern Interconnection In 2015, Shelbie Wickett, Ana Dyreson

Simulated Solar Capacity Including Snow Cover in the Eastern U.S.

Project Summary: We ran PySAM power production simulations for utility-scale (>5 MW) PV sites located in the U.S. Eastern Interconnection in the year 2015. Site panel mounts (fixed-tilt or single-axis tracking), capacities, and locations (latitudes and longitudes) were extracted from Lawrence Berkeley National Laboratory's Utility-Scale Solar 2024 Edition dataset. See 2015_PV_existing_site_metadata.csv file for individual site metadata.


Hourly Simulated Power Production Data With No Snow Loss Model At Existing Utility-Scale Pv Sites (>5 Mw) In The U.S. Eastern Interconnection In 2016, Shelbie Wickett, Ana Dyreson Aug 2025

Hourly Simulated Power Production Data With No Snow Loss Model At Existing Utility-Scale Pv Sites (>5 Mw) In The U.S. Eastern Interconnection In 2016, Shelbie Wickett, Ana Dyreson

Simulated Solar Capacity Including Snow Cover in the Eastern U.S.

Project Summary: We ran PySAM power production simulations for utility-scale (>5 MW) PV sites located in the U.S. Eastern Interconnection in the year 2016. Site panel mounts (fixed-tilt or single-axis tracking), capacities, and locations (latitudes and longitudes) were extracted from Lawrence Berkeley National Laboratory's Utility-Scale Solar 2024 Edition dataset. See 2016_PV_existing_site_metadata.csv file for individual site metadata.


Hourly Simulated Power Production Data With No Snow Loss Model At Existing Utility-Scale Pv Sites (>5 Mw) In The U.S. Eastern Interconnection In 2019, Shelbie Wickett, Ana Dyreson Aug 2025

Hourly Simulated Power Production Data With No Snow Loss Model At Existing Utility-Scale Pv Sites (>5 Mw) In The U.S. Eastern Interconnection In 2019, Shelbie Wickett, Ana Dyreson

Simulated Solar Capacity Including Snow Cover in the Eastern U.S.

Project Summary: We ran PySAM power production simulations for utility-scale (>5 MW) PV sites located in the U.S. Eastern Interconnection in the year 2019. Site panel mounts (fixed-tilt or single-axis tracking), capacities, and locations (latitudes and longitudes) were extracted from Lawrence Berkeley National Laboratory's Utility-Scale Solar 2024 Edition dataset. See 2019_PV_existing_site_metadata.csv file for individual site metadata.


Fabrication Of Antibacterial And Functional Films From Starch-Polyvinylpyrrolidone Composite Using Plasma Treatment And Silver Nanoparticles, Muhammad Nazrul Islam, Nikitha Modupalli, Md Mahfuzur Rahman Aug 2025

Fabrication Of Antibacterial And Functional Films From Starch-Polyvinylpyrrolidone Composite Using Plasma Treatment And Silver Nanoparticles, Muhammad Nazrul Islam, Nikitha Modupalli, Md Mahfuzur Rahman

Food Science Faculty Publications and Presentations

Biopolymers and water-soluble nontoxic synthetic polymer composites using silver nanoparticles are astute approaches for antibacterial film fabrication. Moreover, surface treatment of the biopolymeric composite film by cold plasma can enhance the biocidal activity. Silver nanoparticles were synthesized by using the reduction method. Films were fabricated with different ratios of rice starch and polyvinylpyrrolidones (PVP) (1:0, 1:1, and 3:1), with and without silver (Ag) nanoparticles. A plasma jet was used to treat the film's surfaces by placing the Film 0.5 cm below the plasma discharge. Surface morphology was monitored by scanning electron microscopy (SEM), and the existence of Ag nanoparticles in …


Signaling By Intracellular Β2-Adrenergic Receptors Regulates Ampa Receptor Trafficking And Synaptic Plasticity, Boram Lee, Xiaomin Xing, Kyle E. Ireton, Bing Xu, Paul J. Gasser, Johannes W. Hell Aug 2025

Signaling By Intracellular Β2-Adrenergic Receptors Regulates Ampa Receptor Trafficking And Synaptic Plasticity, Boram Lee, Xiaomin Xing, Kyle E. Ireton, Bing Xu, Paul J. Gasser, Johannes W. Hell

Biomedical Sciences Faculty Research and Publications

Signaling by norepinephrine (NE) via adrenergic receptors (ARs) mediates attention, yet the underlying molecular mechanisms are largely unknown. AMPA receptors (AMPARs) form a complex with β2ARs, Gs, adenylyl cyclase, and protein kinase A (PKA) to augment AMPAR phosphorylation and, thereby, surface expression. We show that signaling by intracellular β2ARs is required for these effects and two different forms of long-term potentiation (LTP) that depend on β2AR signaling and phosphorylation of the AMPAR GluA1 subunit on S845. Inhibition of two NE transporters, the organic cation transporter 3 (OCT3) and the plasma membrane monoamine transporter (PMAT), impairs phosphorylation of the AMPAR GluA1 …


Criminal Adult Perceptions Of Transition Services Following Histories Of Physical Abuse As Children, Kimberlyn Sherie Crook Aug 2025

Criminal Adult Perceptions Of Transition Services Following Histories Of Physical Abuse As Children, Kimberlyn Sherie Crook

Walden Dissertations and Doctoral Studies

It is possible that childhood abuse and neglect could be linked to adult crime and delinquency. Intervention services' apparent ineffectiveness worries social workers, law enforcement, and policymakers. The literature found that abused children are more likely to commit crimes as adults without intervention and prevention, which harms society and abused children. Research suggests child abuse and adult crime may have early roots. The purpose of this qualitative study was to address adult victims firsthand accounts to identify intervention service gaps and suggest improvements. The qualitative design was used to address adult criminals who were abused as children and their unique …


Strategies To Implement Employee Cybersecurity Awareness Programs, Felix Ngwese Aug 2025

Strategies To Implement Employee Cybersecurity Awareness Programs, Felix Ngwese

Walden Dissertations and Doctoral Studies

Lack of cybersecurity awareness among employees and end-users poses significant risks to organizations. This issue is critical because inadequate cybersecurity awareness increases organizational vulnerabilities, leading to financial losses and compromised data security. Grounded in the routine activity theory, the purpose of this qualitative multiple case study was to explore strategies that IT security managers had implemented to enhance employee cybersecurity awareness. The participants were six IT security managers in Cameroon, West Africa, with strategies to implement employee cybersecurity awareness. Data were collected using semistructure interviews and a review of documents. Through thematic analysis, three themes were identified: (a) cybersecurity awareness …


Implementing Clinical Guidelines To Improve The Number Of Inpatient Visits At A Mental Health Clinic, Kimberly Rochelle Miles Aug 2025

Implementing Clinical Guidelines To Improve The Number Of Inpatient Visits At A Mental Health Clinic, Kimberly Rochelle Miles

Walden Dissertations and Doctoral Studies

This DNP quality improvement project focused on addressing a critical gap in psychiatric care: the high rate of missed inpatient mental health visits. Missed follow-up appointments after hospital discharge are associated with medication nonadherence, relapse, hospital readmissions, psychiatric decompensation, and increased emergency department use. In severe cases, they may increase suicide risk. Contributing factors include patient-level barriers such as cognitive impairment, socioeconomic instability, stigma, low motivation, and transportation difficulties, as well as systemic issues like inadequate discharge planning and lack of standardized follow-up protocols. The evidence-based practice question guiding this project was: Will a clinical practice guideline (CPG) improve number …


Leadership In Action: Enhancing Staff Development For Organizational Success, Reinaldo Rivera Hernández Aug 2025

Leadership In Action: Enhancing Staff Development For Organizational Success, Reinaldo Rivera Hernández

Walden Dissertations and Doctoral Studies

Nonprofit organizations face distinctive challenges that require specialized leadership and effective staff development strategies, particularly in community-focused organizations in Lancaster, Pennsylvania. Leadership deficiencies can diminish employee commitment, restrict professional growth, and weaken organizational capacity, ultimately limiting mission fulfillment. The purpose of this qualitative study was to explore leadership and staff development deficiencies within a nonprofit organization in Lancaster County and identify strategies for improvement. Guided by Kurt Lewin’s change management model, the study examined barriers and supports for professional growth, the influence of leadership on organizational culture and retention, and practices promoting equity and succession planning. Semi-structured interviews were conducted …


Exploring Cybersecurity Strategies Used To Protect Personal Health Information From Cyberattacks When Using Telemedicine, Samara Torres Aug 2025

Exploring Cybersecurity Strategies Used To Protect Personal Health Information From Cyberattacks When Using Telemedicine, Samara Torres

Walden Dissertations and Doctoral Studies

The healthcare industry has been impacted by an increase in cybersecurity breaches because of cyberattacks when using telemedicine. It is crucial that information technology (IT) managers in the private healthcare industry protect personal health information (PHI) to uphold patients’ right to privacy, maintain their trust, prevent legal ramifications, and to comply with government regulations. This qualitative pragmatic research used the integrated system theory (IST) as a road map to explore effective cybersecurity strategies used to protect PHI in telemedicine. The participants were seven IT managers in the private healthcare industry within the United States who had experience with cybersecurity strategies …


Staff Education To Improve Mental Health Knowledge Among Critical Care Staff, Ashton Barnes Aug 2025

Staff Education To Improve Mental Health Knowledge Among Critical Care Staff, Ashton Barnes

Walden Dissertations and Doctoral Studies

Mental health literacy is increasingly recognized as a critical component of nursing practice, particularly in high-acuity environments. At a local healthcare organization, leadership identified a gap in staff education related to mental health, contributing to elevated incidences of anxiety, depression, posttraumatic stress disorder (PTSD), burnout, and diminished patient outcomes. In response, I conducted this Doctor of Nursing Practice project to evaluate whether a structured educational intervention could enhance mental health knowledge and competency among critical care staff. Participants completed pre- and postintervention assessments to evaluate core concepts in mental health awareness and clinical application, with supplementary qualitative feedback gathered to …


Effective Employee Retention Strategies To Maintain Generation Y Employees, Patricia Joanna Straughn Aug 2025

Effective Employee Retention Strategies To Maintain Generation Y Employees, Patricia Joanna Straughn

Walden Dissertations and Doctoral Studies

Employee retention for Generation Y workers is still an ongoing challenge for human resource managers. To foster a stable and productive workforce, it is crucial for HR managers to understand and apply effective retention strategies. Grounded in Herzberg’s two-factor motivation theory, this qualitative pragmatic inquiry study aims to identify effective employee retention strategies that human resources managers employ to retain their Generation Y employees. The targeted participants consisted of six human resource managers in the United States who had effectively utilized retention strategies to retain their Generation Y employees. Data were collected using semi structured interviews. Using thematic analysis, five …


Spartan Daily, August 26, 2025, San Jose State University, School Of Journalism And Mass Communications Aug 2025

Spartan Daily, August 26, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 165, Issue 2


What Perceptions Do Esl- Endorsed Teachers In A Midwest-Urban School District Hold Regarding The Achievement Gap Between Their Ells And Non-Ell Students?, Hannah Jeanne Walling Aug 2025

What Perceptions Do Esl- Endorsed Teachers In A Midwest-Urban School District Hold Regarding The Achievement Gap Between Their Ells And Non-Ell Students?, Hannah Jeanne Walling

Masters Projects

In today's diverse and interconnected society, the educational landscape is marked by a significant influx of students who are English language learners (ELLs). These students, while enriching the cultural tapestry of classrooms, face unique challenges in acquiring academic skills and achieving success in their educational journey. This thesis aims to delve into the achievement gap that exists between English language learners and their non-English language learner counterparts and what perceptions their teachers have on them, with a particular focus on the United States educational system. By examining the factors contributing to this disparity, exploring effective instructional strategies, and proposing targeted …


Computer-Aided Reading Of Chest Radiographs For Paediatric Tuberculosis: Current Status And Future Directions, Mackenzie Dupont, Robert Castro, Sandra V Kik, Megan Palmer, James A Seddon, Devan Jaganath Aug 2025

Computer-Aided Reading Of Chest Radiographs For Paediatric Tuberculosis: Current Status And Future Directions, Mackenzie Dupont, Robert Castro, Sandra V Kik, Megan Palmer, James A Seddon, Devan Jaganath

Faculty, Staff and Students Publications

Computer-aided detection (CAD) systems for automated reading of chest x-rays (CXRs) have been developed and approved for tuberculosis triage in adults but not in children. However, CXR is frequently the only adjunctive tool for clinical assessment in the evaluation of paediatric tuberculosis in primary care settings, and children would benefit from CAD models that can detect their unique clinical and radiographic features. To advance CAD for childhood tuberculosis, large, diverse paediatric CXR datasets linked to standardised tuberculosis classifications are required. These datasets would be used to train and validate paediatric-specific models for tuberculosis screening, diagnosis, and severity stratification. Previous studies …


High-Speed Voltage Imaging Of Action Potentials In Molecular Layer Interneurons Reveals Sensory-Driven Synchrony That Augments Movement, Spencer T Brown, Meghana R Holla, Michelle A Land, Shuyuan Yang, Alex J Mcdonald, François St-Pierre, Indira M Raman Aug 2025

High-Speed Voltage Imaging Of Action Potentials In Molecular Layer Interneurons Reveals Sensory-Driven Synchrony That Augments Movement, Spencer T Brown, Meghana R Holla, Michelle A Land, Shuyuan Yang, Alex J Mcdonald, François St-Pierre, Indira M Raman

Faculty, Staff and Students Publications

Testing whether the synchrony of action potential firing is a cerebellar coding mechanism requires simultaneous recording, with high temporal fidelity, from populations of identified neurons. Here, we used targeted one-photon voltage imaging at 2–4 kHz to record action potentials from groups of ~10–300 molecular layer interneurons (MLIs) expressing a positively tuned, genetically encoded voltage indicator, FORCE1f or pAce. In awake resting mice, crus I MLIs fired brief (~1-ms) spikes at 20–60 spikes/s. Sensory stimuli of air puffs to the whiskers evoked short-latency (< 10 ms) increases in spiking probability. In most trials, >50% of MLIs fired synchronously with 4-ms temporal precision. The magnitude of puff-evoked whisks correlated tightly with …


Cathartocytosis: Jettisoning Of Cellular Material During Reprogramming Of Differentiated Cells, Jeffrey W Brown, Xiaobo Lin, Gabriel Anthony Nicolazzi, Xuemei Liu, Thanh Nguyen, Megan D Radyk, Joseph Burclaff, Jason C Mills Aug 2025

Cathartocytosis: Jettisoning Of Cellular Material During Reprogramming Of Differentiated Cells, Jeffrey W Brown, Xiaobo Lin, Gabriel Anthony Nicolazzi, Xuemei Liu, Thanh Nguyen, Megan D Radyk, Joseph Burclaff, Jason C Mills

Faculty, Staff and Students Publications

Injury causes differentiated cells to undergo massive reprogramming to become proliferative and repair tissue via paligenosis. Gastric chief cells use paligenosis to reprogram into progenitor-like spasmolytic-polypeptide-expressing metaplasia (SPEM) cells. Stage 1 of paligenosis is the downscaling of mature cell architecture via a process involving lysosomes. Here, we notice that sulfated glycoproteins are not only digested during paligenosis but also excreted into the gland. Various genetic and pharmacological approaches show that endoplasmic reticulum membranes and secretory granule cargo are also excreted and that the process proceeds in parallel with but is mechanistically independent of autophagy. Three-dimensional light and electron microscopy demonstrated …


Outcomes Of Brexucabtagene Autoleucel In Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia With Cns Involvement, Ibrahim N Muhsen, Gregory W Roloff, Rawan Faramand, Tamer Othman, Yannis Valtis, Noam E Kopmar, Simone E Dekker, Matthew Connor, Santiago Mercadal, Timothy E O'Connor, Kaitlyn C Dykes, Mohamed Ahmed, Nikeshan Jeyakumar, Amy Zhang, Katharine Miller, Katherine C Sutherland, Caitlin Guzowski, Vishal K Gupta, Navneet Majhail, Minoo Battiwalla, Melhem M Solh, Shahbaz A Malik, John Mathews, Caspian H Oliai, Paul Shaughnessy, Luke Mountjoy, Catherine J Lee, Aaron C Logan, Stephanie B Tsai, Jessica T Leonard, Marc Schwartz, Joshua P Sasine, Muthu Kumaran, Noelle Frey, Jae H Park, Divya Koura, Ryan D Cassaday, Bijal D Shah, Ibrahim Aldoss, Lori S Muffly, Laquisa C Hill Aug 2025

Outcomes Of Brexucabtagene Autoleucel In Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia With Cns Involvement, Ibrahim N Muhsen, Gregory W Roloff, Rawan Faramand, Tamer Othman, Yannis Valtis, Noam E Kopmar, Simone E Dekker, Matthew Connor, Santiago Mercadal, Timothy E O'Connor, Kaitlyn C Dykes, Mohamed Ahmed, Nikeshan Jeyakumar, Amy Zhang, Katharine Miller, Katherine C Sutherland, Caitlin Guzowski, Vishal K Gupta, Navneet Majhail, Minoo Battiwalla, Melhem M Solh, Shahbaz A Malik, John Mathews, Caspian H Oliai, Paul Shaughnessy, Luke Mountjoy, Catherine J Lee, Aaron C Logan, Stephanie B Tsai, Jessica T Leonard, Marc Schwartz, Joshua P Sasine, Muthu Kumaran, Noelle Frey, Jae H Park, Divya Koura, Ryan D Cassaday, Bijal D Shah, Ibrahim Aldoss, Lori S Muffly, Laquisa C Hill

Faculty, Staff and Students Publications

Patients with relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL) with central nervous system (CNS) involvement (CNS B-ALL) have poor outcomes and were frequently excluded from CD19-targeting chimeric antigen receptor (CAR) T-cell clinical trials. The efficacy and safety of brexucabtagene autoleucel (brexu-cel) in adults with R/R B-ALL was established by the ZUMA-3 trial, which excluded patients with advanced or symptomatic CNS involvement. In this retrospective multicenter analysis, we investigated the safety and efficacy of brexu-cel in patients with CNS B-ALL using data from the ROCCA (Real-World Outcomes Collaborative for CAR T in ALL) consortium. Of 189 patients who received infusion, 31 …


Pfkfb3 Activates Cad To Enhance De Novo Pyrimidine Synthesis For Cell Growth, Qingen Da, Yongfeng Cai, Qian Ma, Qiuhua Yang, Yapeng Cao, Yaqi Zhou, Dingwei Zhao, Zhiping Liu, Jiean Xu, Junming Quan, Liang Zhang, Rui Wang, Xuejun Jiang, Xiao Liu, Kunfu Ouyang, Zhen Han, Jikui Liu, Tao Wang, Chunxiang Zhang, Neal L Weintraub, David J R Fulton, Jun Zhao, Mei Hong, Zigang Li, Yuqing Huo Aug 2025

Pfkfb3 Activates Cad To Enhance De Novo Pyrimidine Synthesis For Cell Growth, Qingen Da, Yongfeng Cai, Qian Ma, Qiuhua Yang, Yapeng Cao, Yaqi Zhou, Dingwei Zhao, Zhiping Liu, Jiean Xu, Junming Quan, Liang Zhang, Rui Wang, Xuejun Jiang, Xiao Liu, Kunfu Ouyang, Zhen Han, Jikui Liu, Tao Wang, Chunxiang Zhang, Neal L Weintraub, David J R Fulton, Jun Zhao, Mei Hong, Zigang Li, Yuqing Huo

Faculty, Staff and Students Publications

Aerobic glycolysis, termed the Warburg effect, is one of the aberrant metabolic pathways in highly proliferating cells. Glycolysis provides glycolytic metabolites to support the generation of biomass, such as nucleotides, amino acids, and lipids. Research on the direct interactions between glycolysis and other metabolic pathways is an emerging field that has garnered significant interest. Phosphofructokinase-2/fructose-2,6-bisphosphatase 3 (PFKFB3) activates glycolysis by synthesizing fructose-2,6-bisphosphate (F2,6BP), which allosterically activates the rate-limiting enzyme 6-phosphofructo-1-kinase (PFK-1). In this study, we found that PFKFB3 directly interacts with and regulates the phosphorylation of carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD), the enzyme catalyzing the first three …


Investigation Of Co-Current And Counter-Current Multiphase Flow In Upstream Drilling And Production Applications, Hazem Fleifel Aug 2025

Investigation Of Co-Current And Counter-Current Multiphase Flow In Upstream Drilling And Production Applications, Hazem Fleifel

LSU Doctoral Dissertations

In the domain of upstream Petroleum Engineering, the dynamics of co-current and counter-current multiphase flows present huge challenges, significantly impacting the efficiency of associated processes. This study investigates two specific applications concerning these flow behaviors, involving both laboratory experiments and transient computer simulations. This work investigates two distinct well control and production enhancement processes, involving multiphase flow dynamics: the bullheading kill procedure and liquid-assisted gas lift (LAGL).

The first topic (Topic 1) explores the bullheading process, a type of well control methods, by challenging the traditional understanding that gas removal efficiency increases monotonically with injection pump flow rate. Through 1D …


The Role Of Recruited Adipose Stromal Cells And Their Fibroblastic Differentiation In Cancer, Lingyi Cai, Mikhail G Kolonin, Dimitris Anastassiou Aug 2025

The Role Of Recruited Adipose Stromal Cells And Their Fibroblastic Differentiation In Cancer, Lingyi Cai, Mikhail G Kolonin, Dimitris Anastassiou

Faculty, Staff and Student Publications

Adipose stromal cells (ASCs) are perivascular mesenchymal progenitors of adipose tissue. In cancer patients, ASCs can mobilize and migrate to the tumor, where they subsequently play an important role in cancer progression. This biological process involves the conversion of recruited ASCs into cancer-associated fibroblasts (CAFs). ASC-derived CAFs influence the tumor microenvironment through extracellular matrix remodeling, vascularization, and immunomodulation. These and other processes mediated by secreted paracrine factors also affect gene expression in carcinoma cells to promote the epithelial-mesenchymal transition (EMT), metabolic adaptation, survival, and invasiveness of cancer cells. ASC-derived CAFs can enhance tumor aggressiveness, accounting in part for the link …