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Efficient Packaging Of Hiv-1 Genomes Via Recognition Of Its Adenosine-Rich Content By A Heterologous Rna-Binding Domain, Hung Ryan Vuong Jul 2025

Efficient Packaging Of Hiv-1 Genomes Via Recognition Of Its Adenosine-Rich Content By A Heterologous Rna-Binding Domain, Hung Ryan Vuong

Arts & Sciences Graduate Student Theses and Dissertations

RNA-protein interactions underlie many key processes in viral replication and antiviral immune responses. In this thesis, I reported our investigations on the roles of two RNA-binding proteins, Gag and IFIT1, in mediating HIV-1 genome packaging and regulating innate immune gene expression, respectively. The HIV-1 genome comprises a dimer of unspliced, positive sense mRNA (gRNA) that is packaged with high efficiency, with more than 90% of viral particles containing two copies of gRNA. Gag is the major HIV-1 structural protein that coordinates all steps of virion assembly and possesses a nucleocapsid domain (NC) required for gRNA binding and genome packaging. In …


Graduate Student Paper: Aging In A Changing Japan: Gendered Adaptation To Changing Family Structure, Miki Izu, Clayton Chalmers Jul 2025

Graduate Student Paper: Aging In A Changing Japan: Gendered Adaptation To Changing Family Structure, Miki Izu, Clayton Chalmers

Asia Pacific Perspectives

Although Japanese seniors are very healthy, research shows that they are not very happy. Compared to seniors in other developed countries, Japanese elders have lower ratings of subjective well-being and are increasingly alone. This paper argues that changes to Japanese family life help explain why Japanese elders are struggling with low subjective well-being. Specifically, declining marriage rates and declining rates of elders living with their children (co-residency) have made it harder for elders to get the support they need. Moreover, the effect and the adaptations to these changes are not equal between men and women. While elderly Japanese men are …


New York Law School Announces New Chair Of The Board Of Trustees, New York Law School Jul 2025

New York Law School Announces New Chair Of The Board Of Trustees, New York Law School

NYLS Community News

No abstract provided.


Economic Re-Colonisation: Reflections On The New Zealand Treaty Of Waitangi Settlement Process And The Epistemic Violence Of Resolution, David Carter Jul 2025

Economic Re-Colonisation: Reflections On The New Zealand Treaty Of Waitangi Settlement Process And The Epistemic Violence Of Resolution, David Carter

Talking Heads Seminar Series

The 1998 Ngai Tahu-Crown Te Tiriti o Waitangi-Treaty of Waitangi settlement represents a long battle for justice concerning Te Waipounamu (South Island) of Aotearoa, New Zealand.

We focus on the resolution practices of the New Zealand Government and the impacts of financialising historic harm as economic techniques dominate the articulation of resolution. The paper challenges three main ideas. First, it illustrates a logical impossibility in a process of ‘resolution’ determined by the Crown. Second, it challenges the financialisation rhetoric applied in ‘resolving’ harm caused. Third, it challenges the imposition of economic control in requiring Ngai Tahu to establish a corporate …


Evaluating Preference And Reinforcer Assessments For Distinct Social Interactions, Alecksandra Castaneda Jul 2025

Evaluating Preference And Reinforcer Assessments For Distinct Social Interactions, Alecksandra Castaneda

Thesis Projects

The present study evaluated the efficacy of different assessments to assess reinforcer value and order of preference in regard to social interactions. A key component in this study was to expand on forms of social attention that have not typically been assessed, specifically non-physical. The lack of research in this area has led to an extension in understanding the effects of social attention in terms of reinforcement, as well as determining the optimal methods to do so. The researchers conducted a sequence of assessments across participants: concurrent operant reinforcer assessment, social interaction preference assessment, and multiple stimulus without replacement preference …


A Wachspress-Type Rational Characteristic Method For Solving First-Order Hyperbolic Equations, Mohamed Al-Lawatia Jul 2025

A Wachspress-Type Rational Characteristic Method For Solving First-Order Hyperbolic Equations, Mohamed Al-Lawatia

Sultan Qaboos University Journal For Science

This paper introduces a characteristic method for solving linear first-order hyperbolic partial differential equations in two space dimensions. The algorithm employs rational Wachspress-type basis functions applied to a hexagonal discretization of the domain, integrated within the Eulerian-Lagrangian Localized Adjoint Method (ELLAM) framework. The proposed scheme preserves the strengths of characteristic methods and delivers accurate numerical results, even with large time steps. Computational tests conducted on standard benchmark problems illustrate the effectiveness of the method.


Optimizing Thermal Performance Of Ag-Mgo/H2O Hybrid Nanofluid Flow In A Quarter-Circular Cavity Using Response Surface Methodology And Artificial Neural Network, M.S. Alam, M.N. Huda, M.M. Rahman, M. Al-Lawati Jul 2025

Optimizing Thermal Performance Of Ag-Mgo/H2O Hybrid Nanofluid Flow In A Quarter-Circular Cavity Using Response Surface Methodology And Artificial Neural Network, M.S. Alam, M.N. Huda, M.M. Rahman, M. Al-Lawati

Sultan Qaboos University Journal For Science

This research analyzes the optimization of the thermal performance of the natural convective flow of Ag-MgO/H2O hybrid nanofluid within a quarter-circular cavity utilizing response surface methodology (RSM) and artificial neural network (ANN) techniques through a non-homogeneous dynamic mathematical model. The Galerkin-weighted residual finite element method numerically solves the governing dimensionless equations and boundary conditions. The numerical results are then used to train ANN and RSM models and evaluate their performance. The results indicated that both models are dependable for this investigation, exhibiting a notably high coefficient of determination for the performance control variable, the average Nusselt number. In addition, the …


Analysis Of Stress-Jump Condition On The Onset Of Thermal Convection In A Composite System Formed By An Anisotropic Porous Layer Underlying A Fluid Layer, Neetu Srivastava, Naveen Dwivedi, Ashok K. Singh, Nirmal C. Sacheti, B. S. Bhadauria Jul 2025

Analysis Of Stress-Jump Condition On The Onset Of Thermal Convection In A Composite System Formed By An Anisotropic Porous Layer Underlying A Fluid Layer, Neetu Srivastava, Naveen Dwivedi, Ashok K. Singh, Nirmal C. Sacheti, B. S. Bhadauria

Sultan Qaboos University Journal For Science

This paper investigates the onset of thermal convection in a bounded system comprising a horizontal viscous fluid layer of infinite extent overlying an anisotropic horizontal permeable layer saturated with the same fluid. It is assumed that this system is heated from below and cooled from above in the presence of internal heat generation. It is also assumed that the material parameters, such as viscosity and thermal conductivity differ between the layers, and that the Brinkman model is used to describe the flow in the porous region. An extensive linear stability analysis has been performed with an aim to determine the …


Spreading Of Effluent Discharges From Two Adjacent Outfalls On A Sloping Seabed In Spring-Neap Tidal Waters, Anton Purnama, Ahmed Al-Kasbi, Easwaran Balakrishnan Jul 2025

Spreading Of Effluent Discharges From Two Adjacent Outfalls On A Sloping Seabed In Spring-Neap Tidal Waters, Anton Purnama, Ahmed Al-Kasbi, Easwaran Balakrishnan

Sultan Qaboos University Journal For Science

Coastal industrial plants dispose of their wastewater effluents into shallow coastal waters through sea outfalls. When two or more outfalls along a coastline are discharging, the long-term impacts are interdependent. Analytical solutions of two-dimensional advection-diffusion equations with a two-point source in a spring-neap oscillating tidal current on a sloping seabed are presented to study the far-field merging and interaction of two discharged effluent plumes in coastal waters. The elongated plumes are spreading towards the shoreline, and thus, asymptotic approximation is made to the analytical solution to assess the long-term build-up of effluent concentration at the shoreline. To show case the …


N-Fold Symmetric Quasicrystallography As The Projection Of The Affine Coxeter Group WA(BN), Nazife Ozdes Koca, Mehmet Koca, Ramazan Koc, Amira Al Maqbali Jul 2025

N-Fold Symmetric Quasicrystallography As The Projection Of The Affine Coxeter Group WA(BN), Nazife Ozdes Koca, Mehmet Koca, Ramazan Koc, Amira Al Maqbali

Sultan Qaboos University Journal For Science

Quasicrystals are obtained as the projections of higher dimensional cubic lattices. This paper aims to show that the affine dihedral subgroup Wa(I2(h)) of the affine group Wa(Bn), h = 2n being the Coxeter number, offers a different perspective to -fold symmetric quasicrystallography. The affine group Wa(I2(h)) is constructed as the subgroup of the affine group Wa(Bn), the symmetry of the cubic lattice ℤn. The infinite discrete group with local dihedral symmetry of order 2 operates on the concentric -gons obtained by projecting the Voronoi cell of the cubic lattice with 2n vertices onto the Coxeter plane. Voronoi cells tiling the …


N5 As A Subalgebra Of A Principally Ordered Naturally Ordered Regular Semigroup With A Zero Element, G.A. Pinto Jul 2025

N5 As A Subalgebra Of A Principally Ordered Naturally Ordered Regular Semigroup With A Zero Element, G.A. Pinto

Sultan Qaboos University Journal For Science

We start with a basic and technical result: If S is a principally ordered regular semigroup that has a zero element, 0, then 0* is the biggest element (in fact, idempotent) of S. We obtain necessary and sufficient conditions for a principally ordered naturally ordered regular semigroup, S, with a zero element, to have as a subalgebra an ordered and algebraic isomorphic copy of N5, the smallest naturally ordered non-orthodox regular semigroup with a biggest idempotent.


Effect Of Rotation On Plane Wave Propagation In A Magneto-Thermo Elastic Solid, G Rajkumar, K Somaiah, Srinivas Remidi Jul 2025

Effect Of Rotation On Plane Wave Propagation In A Magneto-Thermo Elastic Solid, G Rajkumar, K Somaiah, Srinivas Remidi

Sultan Qaboos University Journal For Science

The present article deals with the effect of angular rotation on the propagation of plane harmonic waves in a homogeneous, isotropic magneto-thermo elastic medium. The governing equations of a generalized magneto-thermo elastic solid are formulated and solved with the method of plane harmonic solution. Three types of waves, namely, plane longitudinal, magneto, and magneto-thermal waves, are significantly affected by the angular rotation of the solid. It is very interesting to observe that the classical result is obtained as angular rotation vanishes. For computational purposes, the available lithium niobate (LiNbO3) material was treated as the model of thermo-magneto elastic medium. The …


Finite Sets With Large Algebraic Closures In Nilpotent Groups, Omar Al Raisi, Mohammad Shahryari Jul 2025

Finite Sets With Large Algebraic Closures In Nilpotent Groups, Omar Al Raisi, Mohammad Shahryari

Sultan Qaboos University Journal For Science

Algebraic sets play a central role in algebraic geometry over groups; by definition, an algebraic set is the set of common roots of a collection of equations in some non-commuting variables x1, ..., xn having coefficients in some group G. Often, one seeks solutions of equations over G in the affine n-space Gn; such systems of polynomial equations are termed Diophantine systems. In this brief note, we consider Diophantine systems over a group G that is assumed to be nilpotent of class c and to have an element of infinite order in its center; we associate with each n × …


Preface, - Squjs Jul 2025

Preface, - Squjs

Sultan Qaboos University Journal For Science

This Mathematics Special Topic Issue contains invited and selected papers presented at the International Conference: Recent Trends in Mathematics (ICM-SQU2024) held during March 6-8, 2024 at Sultan Qaboos University (SQU), Muscat, Oman. The conference was sponsored by SQU, the Oman Mathematics Committee (OMC), and Vodafone (Oman). The conference aimed to provide a platform for researchers, and academicians to present their work, share experiences, and discuss emerging areas in Mathematics. ICM-SQU2024 was inaugurated by Her Excellency Professor Rahmah Bint Ibrahim AlMahrooqi, the Minister of Higher Education, Research and Innovation and His Highness Sayyid Dr. Fahad Bin Al-Julanda Al-Said, the Vice-Chancellor of …


Ingenious Impulsiveness Of Environmentally Motivated Female Entrepreneurship For Sustainable Development, Saranya Senthilnathan, Chandrasekar Kaliyaperumal Jul 2025

Ingenious Impulsiveness Of Environmentally Motivated Female Entrepreneurship For Sustainable Development, Saranya Senthilnathan, Chandrasekar Kaliyaperumal

Management Dynamics

Women's roles are crucial to the economic prosperity of any nation, with their participation in entrepreneurship being a key driver of sustainable development. This study focuses on the contributions of women entrepreneurs in India, highlighting their potential to advance economic, social, and environmental sustainability. The purpose is to examine the role of female entrepreneurs in promoting sustainable practices within the economy, society, and ecology. The study employs a descriptive research design to assess how integrating environmental factors into female entrepreneurship impacts the growth and sustainability of the Indian economy. A self-administered questionnaire was used to collect primary data from 355 …


Antibacterial Potential Of Tapanuli Orangutan (Pongo Tapanuliensis) Food In Batang Toru Forest Against Escherichia Coli And Salmonella Typhi, Herna Febrianty Sianipar, Wahyu Widoretno, Luchman Hakim, Rezi Rahmi Amolia, Fatchiyah Fatchiyah Jul 2025

Antibacterial Potential Of Tapanuli Orangutan (Pongo Tapanuliensis) Food In Batang Toru Forest Against Escherichia Coli And Salmonella Typhi, Herna Febrianty Sianipar, Wahyu Widoretno, Luchman Hakim, Rezi Rahmi Amolia, Fatchiyah Fatchiyah

Karbala International Journal of Modern Science

Diarrhea is a common disease affecting orangutans, primarily caused by Escherichia coli and Salmonella typhi bacteria. To treat this disease, antibacterial food sources are essential as therapeutic agents for orangutans. The fruits consumed by Tapanuli orangutans include Campnosperma auriculatum, Agathis borneensis, Artocarpus heterophyllus, Castanopsis argantea, and Aglaia tomentosa. This study aims to examine the amino acid and phytochemical components with potential antibacterial properties in these five fruit species and their inhibitory effects on E. coli and S. typhi growth through cell lysis, observed using a Scanning Electron Microscope (SEM). The samples were tested for amino acids, phytochemicals, vitamin C content, …


The Reluctant Heroes: How To Teach Younger Generations Every-Day Heroism Through Pedagogical Imagination, Jarema Drozdowicz Jul 2025

The Reluctant Heroes: How To Teach Younger Generations Every-Day Heroism Through Pedagogical Imagination, Jarema Drozdowicz

Heroism Science

This article explores the notion of pedagogical imagination in the context of its practical use in teaching young learners today. The idea of imagination is being presented through the lens of the existing concepts such as ethnographic, historical, and sociological imagination introduced in the social sciences and humanities by various authors. The educational setting of today’s digitalized reality is being understood here as a sociocultural sphere where different generations clash in their diverse abilities to learn and form specific skills that might help them to cope with difficult real life situations. The process of forming heroic behavior patterns is thus …


Can Breastfeeding Lower The Risk Of Childhood Leukemia? Insights From A Duhok Study, Iraq. Case Control Study, Bashar I. Mohammed, Akrem Mohammad Atrushi, Ibrahim A. Naqid, Eman Hussien Ali, Raad Ersan Omar, Kavi Mohamad Sadoun, Daveen Abdulsatar Muhammad, Baderkhan Ihsan Abdullah, Huda Hayder Mohammed, Elaf Firas Salim Jul 2025

Can Breastfeeding Lower The Risk Of Childhood Leukemia? Insights From A Duhok Study, Iraq. Case Control Study, Bashar I. Mohammed, Akrem Mohammad Atrushi, Ibrahim A. Naqid, Eman Hussien Ali, Raad Ersan Omar, Kavi Mohamad Sadoun, Daveen Abdulsatar Muhammad, Baderkhan Ihsan Abdullah, Huda Hayder Mohammed, Elaf Firas Salim

Al-Ameed Journal for Medical Research and Health Sciences

IntroductionThis study aimed to examine the association between breastfeeding practices and the risk reduction of childhood leukemia, and to identify the optimal breastfeeding duration for infant health. A case-control design was used, involving children aged 0–16 years diagnosed with leukemia and a matched control group without leukemia.MethodsData were collected on breastfeeding duration, type of feeding during the first six months, maternal characteristics (age, education, smoking during pregnancy, abortion history, birth control pill use), and child-related variables (sex, age at diagnosis, and birth order). Statistical analysis was conducted using SPSS Version 27. Odds ratios (ORs) and 95% confidence intervals (CIs) were …


Interactive And Navigable Video Transcripts For Television, Shun-Wei Wu Jul 2025

Interactive And Navigable Video Transcripts For Television, Shun-Wei Wu

Defensive Publications Series

Navigating video transcripts on television platforms using standard remote controls presents challenges due to the limited input functionality via the available buttons of standard TV remotes. This disclosure describes techniques that enable an interactive video transcript viewing experience optimized for television platforms (lean-back, remote-controlled display environments). Upon entering a transcript view, an outline box is displayed around the currently synchronized transcript line, providing clear entry and focus affordance. The user can navigate through the transcript lines using standard, limited-input remote controls. While a specific transcript line is being focused upon, a press of the OK button of the remote results …


Semantic Policy Summaries And Semantic Explanations For Explainable Ai In Networking, Dennis Lanov Jul 2025

Semantic Policy Summaries And Semantic Explanations For Explainable Ai In Networking, Dennis Lanov

Defensive Publications Series

Proposed herein is an explainability technique, referred to herein as a "Semantic Policy Summaries and Semantic Explanations" technique, for artificial intelligence (AI) -driven networking that translates complex model decisions into clear, human-readable explanations grounded in real-world network concepts. Instead of abstract outputs like feature scores, the proposed technique delivers goal-oriented justifications for AI network-related decisions/actions. The proposed technique integrates directly into a control loop, supports policy-based triggering, and logs explanations with decision metadata for audit and regulatory review. Further, the proposed technique aligns with requirements from the European Union (EU) AI Act and the proposed United States (U.S.) SAFE Innovation …


Gain Movie Insights Using Generative Artificial Intelligence, Akash Verma, Vineet Kumar, Abhay Kumar Gupta, Vivek Yadav, Szu-An Lu, Meng-Ting Tsai, Ya Hsien Liu, Chu-Feng Lien Jul 2025

Gain Movie Insights Using Generative Artificial Intelligence, Akash Verma, Vineet Kumar, Abhay Kumar Gupta, Vivek Yadav, Szu-An Lu, Meng-Ting Tsai, Ya Hsien Liu, Chu-Feng Lien

Defensive Publications Series

A television (TV) application may present various types of media content of interest to a user. The media content may have different formats such as streaming video and audio. The types of media content may include, but are not limited to, movies, television shows, live sporting events, news items, short form videos, and music. In addition, or in the alternative, a variety of media content providers may deliver various types of media content for viewing by the user. The TV application may deliver a customized viewing experience to a user that spans the diverse types of media content provided by …


Achieving Equity For International Medical Graduates: A Systematic Review, Sangeeta G. Saxena, Elizabeth Tisdell, Elana Farace, Thomas Godfrey, Betsy Aumiller, Esther Dell, Omrana P. Razzak, Bernadette N. Kumar, Kristin K. Sznajder Jul 2025

Achieving Equity For International Medical Graduates: A Systematic Review, Sangeeta G. Saxena, Elizabeth Tisdell, Elana Farace, Thomas Godfrey, Betsy Aumiller, Esther Dell, Omrana P. Razzak, Bernadette N. Kumar, Kristin K. Sznajder

Public Health

Introduction: Foreign-born and foreign trained International Medical Graduates (FIMGs) face greater challenges in acculturation to their host countries than IMGs who train abroad and return to practice in their home country. As FIMGs are likely to fulfill a shortage of physicians in High Income Countries in the foreseeable future, we conducted a systematic review of literature to identify acculturation interventions that help FIMGs assimilate better in their host country health systems. This improves their productivity and satisfaction, allows health systems to be more accepting of FIMGs, and most importantly, enhances patient outcomes.

Methods: Following the PRISMA statement, we searched PubMed, …


Edmore And Webster Coulee Hydrologic Simulation Data, Sharhad Wainty, Taufique H. Mahmood Jul 2025

Edmore And Webster Coulee Hydrologic Simulation Data, Sharhad Wainty, Taufique H. Mahmood

Datasets

The authors compiled a hydrologic model for the Edmore at Edmore and Edmore at Webster Coulee Basin using Cold Region Hydrologic Platform. The datasets include observed and simulated streamflow, observed climatic data, land use maps and hydrological representative unit maps (HRU) maps. This study detected a mechanism of hydrologic change to wetting using a cold region hydrologic model during 1991-2024 period.


Uptake, Distribution, And Activity Of Pluronic F68 Adjuvant In Wheat And Its Endophytic Bacillus Isolate, Anthony Cartwright, Mohammad Zargaran, Anagha Wankhade, Astrid Jacobson, Joan E. Mclean, Anne J. Anderson, David W. Britt Jul 2025

Uptake, Distribution, And Activity Of Pluronic F68 Adjuvant In Wheat And Its Endophytic Bacillus Isolate, Anthony Cartwright, Mohammad Zargaran, Anagha Wankhade, Astrid Jacobson, Joan E. Mclean, Anne J. Anderson, David W. Britt

Biological Engineering Student Research

Surfactants are widely utilized in agriculture as emulsifying, dispersing, anti-foaming, and wetting agents. In these adjuvant roles, the inherent biological activity of the surfactant is secondary to the active ingredients. Here, the hydrophilic non-ionic surface-active tri-block copolymer Pluronic® F68 is investigated for direct biological activity in wheat. F68 binds to and inserts into lipid membranes, which may benefit crops under abiotic stress. F68’s interactions with Triticum aestivum (var Juniper) seedlings and a seed-borne Bacillus spp. endophyte are presented. At concentrations below 10 g/L, F68-primed wheat seeds exhibited unchanged emergence. Root-applied fluorescein-F68 (fF68) was internalized in root epidermal cells and …


Kids Exploring The World With Chatbots, Maggie Mckay, Mark Connelly Jul 2025

Kids Exploring The World With Chatbots, Maggie Mckay, Mark Connelly

Parent-ish Podcast

Are your kids chatting away with AI? In this episode, we provide parents with the tools they need to understand the implications of children's interactions with chatbots. Find out what signs to look for and how to set healthy boundaries to protect your child from potential pitfalls of digital companionship.

Click here to stream the podcast episode.


Supporting Children In Managing Extracurricular Activities, Maggie Mckay, Simone Moody Jul 2025

Supporting Children In Managing Extracurricular Activities, Maggie Mckay, Simone Moody

Parent-ish Podcast

As the school year nears, so do busy schedules and the "extras" that kiddos do outside of school. While children love their sports, clubs and other extracurriculars, it can be hard to balance them with school and other important activities. Simone Moody, PhD, Clinical Psychologist at Children's Mercy in Kansas City, discusses signs your child might be overextended, how to find balance and more in this podcast.

Click here to stream the podcast episode.


Mapping The Literature On Short-Selling In Financial Markets: A Lexicometric Analysis, Nitika Sharma, Sridhar Manohar, Bruce A. Huhmann, Yam B. Limbu Jul 2025

Mapping The Literature On Short-Selling In Financial Markets: A Lexicometric Analysis, Nitika Sharma, Sridhar Manohar, Bruce A. Huhmann, Yam B. Limbu

Department of Marketing Faculty Scholarship and Creative Works

This study provides a comprehensive assessment and synthesis of the literature on short-selling. It performs a lexicometric analysis, providing a quantitative review of 1093 peer-reviewed journal articles to identify and illustrate the main themes in short-selling research. Almost half the published literature on short-selling is thematically clustered around portfolio management techniques. Other key themes involve short-selling as it relates to risk management, strategic management, and market irregularities. Descending hierarchical classification examines the overall structure of the textual corpus of the short-selling literature and the relationships between its key terms. Similarity analysis reveals that the short-selling literature is highly concentrated, with …


Effects Of Intermittent Fasting On Glycemic Markers In Patients With Insulin Resistance, Caitlin Malon Jul 2025

Effects Of Intermittent Fasting On Glycemic Markers In Patients With Insulin Resistance, Caitlin Malon

Summer Interdisciplinary Research Symposium

Objective: The purpose of this research investigation is to evaluate the impact of intermittent fasting on glycemic control in patients with prediabetes or metabolic syndrome.

Methods: A structured literature review was conducted using Google Scholar to identify relevant studies published within the last five years. Search terms included "Insulin Resistance, Intermittent Fasting," "Prediabetes, Intermittent Fasting," and "Intermittent Fasting, Metabolic Syndrome." Inclusion criteria were English-language, full-text articles focusing on intermittent fasting interventions in populations with prediabetes or metabolic syndrome. Studies were excluded if they were published more than five years ago, focused solely on weight loss, or included participants …


Assay Development For The Identification Of Novel Therapeutics To Treat Heart Failure And Skeletal Muscle Disorders, Micah C. Israel, Brooke Ferkull, Thomas Goyne Jul 2025

Assay Development For The Identification Of Novel Therapeutics To Treat Heart Failure And Skeletal Muscle Disorders, Micah C. Israel, Brooke Ferkull, Thomas Goyne

Summer Interdisciplinary Research Symposium

This project is a collaborative effort between Pelagos Pharmaceuticals & Valpo U. Overall goal = develop drugs that will halt &/or reverse congestive heart failure and skeletal muscle disorders by targeting two nuclear receptors: Rev-Erb & the estrogen-related receptors (ERRs). The work reported here is focused on the treatment of mouse myoblasts (skeletal muscle cell precursors) with potential ERR agonists & then looking for protective changes in gene expression.


Adjunctive Radiotherapy In The Management Of Atypical Meningiomas, Madison Janickovic Jul 2025

Adjunctive Radiotherapy In The Management Of Atypical Meningiomas, Madison Janickovic

Summer Interdisciplinary Research Symposium

Objective: This study aims to evaluate whether post-operative adjunctive radiotherapy (PORT) reduces recurrence rates and improves overall survival (OS) in patients diagnosed with grade II/atypical meningiomas (AMs).

Methods: A systematic search was conducted using Google Scholar with primary search terms including “meningiomas,” “surgical resection,” and “radiotherapy,” yielding 4,830 results. Inclusion criteria were limited to peer-reviewed articles published in English from 2019 or later. Studies published before 2019 or in non-English languages were excluded. Key outcomes analyzed included recurrence rates, progression-free survival (PFS), and overall survival.

Results: Evidence suggests that PORT following gross total resection (GTR) of AMs does not significantly …