Digital Commons Network^™

Effect Of Bond Strength Variation And Ionizing Radiation On Mutations In Cytosine-Guanine Islands, Joshua Robert Bedwell, Yan Poniatovskyi, Vola Andrianarijaona

Achieve

Ionizing radiation produces free electrons within cells which then ionizes DNA and has the potential to cause carcinogenic mutations. Cytosine-Guanine (CpG) islands are regions that are rich in cytosine and guanine bases and are common sites of single point mutations and strand breaks. In this study, density function theory (DFT) is used to calculate the potential energy of DNA nucleotide dimers varying bond lengths in five different ionized states. Crossing between two ionized states can be seen in the potential energy curves, indicating the possibility of natural transition between the two states. Potential energy curves are used to determine bond …

Analyzing The Strength Of The Amine Bond Of Guanine Via Potential Curve Analysis: A Computational Approach, Yan Poniatovskyi, Joshua Robert Bedwell, Vola Andrianarijaona

Achieve

The deamination of guanine can be a cause of single point DNA mutations. In this study, the strength of the amine bond was examined using DFT and B3LYP to map out the bond’s potential curves under conditions of various charges being imposed on the molecule. Such an approach yielded a few potential curves that do not exhibit the expected behavior and rather, show crossings in potential energy curves. Discussions regarding the suspected causes of these unexpected behaviors are included in the poster presentation. The Mulliken charge analysis of guanine under these conditions is coherent with the proposition that the deamination …

Zero/Low Textbook Cost Syllabus For [39335 Eng 2100 - Htrf Writing I], Ju Ly Ban

Open Educational Resources

This class is a warm-up for the many writing assignments you will encounter, no matter your major. We will read, write, and talk through texts in different genres, learning how to (1) understand what a writing task is asking for (2) build clear arguments (3) find strong evidence and (4) manage time and writing anxiety. These skills will help you revisit, rethink, and expand your own resources.

You are the writer. (Yes, even if you use ChatGPT. We will talk about how to use it well, too.) And you already have your resources. Let’s begin in an imaginary living room—the …

Plant-Microbe Interactions Across Scales: Diversity, Disease, And Stress In Herbaceous Plant Communities, Philippa Tanford

Arts & Sciences Graduate Student Theses and Dissertations

Plants interact consequentially with microbes spanning mutualism to pathogenicity, with broader effects on large-scale plant community structure. These plant communties, in turn, shape below and aboveground microbial communities through a variety of mechanisms. However, plant diversity-microbial diversity relationships remain broadly inconsistent across environments and among different plant and microbial assemblages. In my dissertation, I work to bridge some of these gaps in plant-microbial ecology in three experimental chapters assessing relationships between plant diversity and microbial diversity, including the influence of belowground-aboveground microbiome interactions, the influence of drought stress, and incorporating different spatial and experimental scales. First, I explore the microbial …

Strategies To Recommend Compliance For Cna Staffing Ratios In New Jersey Nursing Homes, Mira Gaba

Walden Dissertations and Doctoral Studies

Skilled nursing facilities (SNFs) in New Jersey, which provide both short-term rehabilitation and long-term residential care, are faced with mounting pressure due to mandated staffing ratios for certified nursing assistants (CNAs). The purpose and review question for this integrative review centered on best practices and strategies for nursing home leaders to meet the new Centers for Medicare & Medicaid Services and New Jersey standards for CNA staffing ratios in nursing homes. This review used the systems theory to look at SNFs as connected networks where staffing, leadership, finances, and care delivery all work together. An examination of the literature published …

Strategies To Improve Psychiatrist Understaffing In Psychiatric Hospitals In Rural And Underserved Communities: Addressing Administrative Challenges, Carla Aramouni

Walden Dissertations and Doctoral Studies

Psychiatric hospitals across the United States face a worsening shortage of psychiatrists, particularly in rural and underserved communities, which limits timely mental health care, increases wait times, and places unsustainable strain on the psychiatric workforce. The purpose of this integrative review was to identify administrative strategies that can mitigate psychiatrist understaffing and support sustainable care delivery in psychiatric hospitals. An integrative review methodology was used to explore both empirical and nonempirical literature, resulting in 92 articles, including 32 peer-reviewed sources and several supporting studies selected through a systematic search, screening, and critical appraisal. Thematic analysis of the evidence revealed five …

Prioritising Time-Critical Injuries And Interventions For Trapped Motor Vehicle Collision Patients: A Delphi Study, Tim Nutbeam, Rob Fenwick, Ian Marritt, Brian Lee, Luke Staveley-Wadham, Nigel Lang, Louise Johnson, Nicolas Mattock, Jane Ogilvie, Emily Foote, Francis Screech, Lara Lebeau–Humarau, Caroline Leech

Peninsula Medical School

Background Physically trapped patients following motor vehicle collisions are at high risk of time-critical injuriesand poor outcomes. Despite this, there is limited consensus on which injuries should be prioritised and which earlyinterventions are both necessary and feasible in the prehospital setting. This study aims to develop expert consensuson injury categorisation and the delivery of early care interventions to guide clinical and operational decision-makingat the scene.Methods A modified Delphi method was used to gather consensus from a multidisciplinary panel of subjectmatter experts, including clinicians, paramedics, and members of fire and rescue services. In Round 1, participantscontributed to the development of draft …

An Investigation Of Parental Involvement In The Safe Passage Initiative (An Anti-Violence Program), Danielle King

Electronic Theses and Dissertations

This dissertation investigates the issue of parental involvement in Safe Passage, an anti-violence initiative operating within seven Pittsburgh Public Schools. Recognizing the involvement of parents is critical for successful violence prevention, this study explores the barriers hindering meaningful participation and identifies strategies to enhance parent-school-community collaboration.

Utilizing qualitative research methods, the study captures insights from parents, educators, and community stakeholders through a reflective Journey Line activity and focus group discussion. Data collected revealed several significant barriers such as inconsistent communication, limited parental availability due to demanding work schedules, mental and emotional exhaustion, cultural disconnects, and a lack of clarity regarding …

Kraemer Is 2025 Distinguished Alumni Award Recipient, Communications And Marketing

Campus News Archive

No abstract provided.

Diagnosing And Testing Gi Motility, Michael Smith, Sofia Colon Guzman

Pediatrics in Practice: A CME Podcast

We dive into the most common pediatric GI motility disorders, when to refer for testing, and how to navigate diagnostics like manometry and gastric emptying studies. Learn how to approach testing in non-verbal children, distinguish functional from structural issues, and stay updated on emerging tools in the field.

Click here to stream the podcast episode.

Sac Newsletter 2025, South Asia Center

Newsletters from the South Asia Center

No abstract provided.

Humidity Control Apparatus And Materials, Ying Zhong

USF Patents

A ventilation port maintains the humidity range within a sealed or partially sealed enclosure maintaining a level of atmospheric moisture such as a greenhouse. The port is comprised of a polymer blend film made of a hydrophilic component serving as the water-absorbing material and substrate component serving as the mechanical backbone. The film is designed to bend and open the port when the humidity within the enclosure exceeds a predetermined level outside the humidity range, allowing for the venting of excess humidity. Once the humidity falls back within the desired range, the film returns to its original state and closes …

Bronchopulmonary Dysplasia Diagnosis And Screening, Bob Underwood, Winston Manimtim

Pediatrics in Practice: A CME Podcast

Winston Manimtim, MD, discusses bronchopulmonary dysplasia including affects and complications, provides guidance to pediatricians working with patients with BDP and more in this episode.

Click here to stream the podcast episode.

Moments

DePaul Magazine

Photo spread of DePaul students with mascot DIBS in St. Vincent's Circle on the Lincoln Park Campus.

From The President

DePaul Magazine

President Robert L. Manuel shares how the School of Music, The Theatre School and The Art School play an integral role in shaping DePaul's vibrant arts and humanities ecosystem.

Making A Difference

DePaul Magazine

Tom Mendel (SOM ’78), a veteran Chicago bassist who has plied his trade in musical theatre venues, jazz clubs, recording studios and school classrooms, creates a scholarship for DePaul music performance students pursuing a similar path.

'The Dean' To Share His Ole Miss Stories, Michael Newsom

University of Mississippi News

OXFORD, Miss. – For 36 years, he was a steady hand guiding University of Mississippi students through triumphs and crises, celebrations and challenges. Now Sparky Reardon, the university's beloved former dean of students, will pull back the curtain on decades of campus history that shaped generations.

Social Buffering By Siblings In Childhood And Adolescence, Deborah Han, Natalie A. Thwaites, Julia Olson, Kenia Rivera, Julia Dmitrieva, Jenalee R. Doom

Psychology: Faculty Scholarship

Although positive sibling relationships are associated with better developmental outcomes for children and adolescents, it is unknown whether siblings may be effective social buffers of physiological stress. In addition, there is little research on whether depressive symptoms may moderate the effectiveness of social buffering. The current study examined (1) whether siblings, compared to strangers, buffered the cortisol response to a social evaluative stressor in children and adolescents, (2) whether depressive symptoms moderated this effect, and (3) whether self-reported sibling relationship quality influenced sibling buffering effectiveness. A total of 72 children (9-11 years) and 65 adolescents (15-17 years) were randomly assigned …

Tradition, Critque, And The Modern Moral Lingua Franca: A Lutheran Articulation Of Human Rights Language, Christian B. Dollar

Doctor of Philosophy Dissertation

The language of subjective, individual rights has become the primary way of speaking about the rights and wrongs of human life together. Since the end of World War II, one subset of this language—that of human rights—has achieved a global influence. The various Christian traditions of the west have, in large part, adopted this language of human rights to articulate and supplement their assorted social teachings. Yet, the adoption of human rights language has been contested by a dedicated cadre of Roman Catholic and Protestant theologians concerned about the potentially anti-Christian implications inherent in the grammar of rights. Christian rights …

The Power Of Service Learning At Byu, Yoshihiko Ariizumi

Spiritual Proficiency

This article summarizes the merits of Service Learning for university students.

Educating Nurses On The Agency Of Healthcare Research And Quality Pressure Ulcer Prevention Program To Reduce The Rate Of Pressure Ulcers, Marie France Destaul

Walden Dissertations and Doctoral Studies

A staff development project was conducted to address the practice problem encountered in a healthcare setting. The identified gap in practice was related to a lack of knowledge of pressure ulcer injury prevention among inpatient staff. Leadership deemed it essential to address this practice problem in nursing care because the prevalence of pressure ulcer injuries in hospitalized patients was high. The following practice-focused question guided the project: For staff in an inpatient setting, will education on the Agency of Healthcare Research and Quality (AHRQ) Pressure Ulcer Prevention Program increase knowledge toward the goal of decreasing the incidence of pressure ulcers? …

Predictability And The Pleasure Of Music, Amy M. Belfi

Psychological Science Faculty Research & Creative Works

No abstract provided.

Is Health Insurance Related To Breastfeeding Duration?, Anna De La Paz

Population Health Research Brief Series

Breastfeeding duration, which plays an important role in shaping maternal and infant health, can be influenced by insurance type. This data slice uses data from the 2022-2023 National Survey of Family Growth (NSFG) to described differences in breastfeeding duration by insurance type among females ages 15-49 in the United States. Findings show that mothers with private insurance breastfeed longer than mothers with public insurance, such as Medicaid, net of controls for maternal age, race, education, and income.

More Than A Building: The Enduring Legacy Of Unh’S Thompson Hall, Scott Ripley

UNH Today Archive

No abstract provided.

Reducing Wildlife-Vehicle Collisions In New Hampshire, Mark Wanner

UNH Today Archive

No abstract provided.

Revisiting The Effect Of Udenafil On Exercise Performance In Patients With Fontan Circulation: Results Of A Post Hoc Analysis Of The Fuel Trial, David J Goldberg, William B Orr, Et Al.

2020-Current year OA Pubs

BACKGROUND: In the FUEL (Fontan Udenafil Exercise Longitudinal) trial, a positive treatment effect was identified for outcomes at the ventilatory anaerobic threshold but not for the primary outcome, oxygen consumption (Vo

METHODS: Participants were divided into subgroups by baseline predicted peak Vo

RESULTS: Of the 379 participants with paired exercise data, 302 (80%) had a baseline peak Vo

CONCLUSIONS: In this post hoc subgroup analysis, after exclusion of patients with Fontan circulation with near-normal baseline peak Vo

REGISTRATION: URL: https://clinicaltrials.gov; Unique identifier: NCT0274115.

Bcg Vaccine-Induced Innate And Adaptive Pulmonary Immunity Correlating With Protective Efficacy Against Mycobacterium Tuberculosis In The Lungs, Mayank Khanna, Alistair J. Ramsay

School of Graduate Studies Faculty Publications

Background/Objectives: Effective prophylaxis for Mycobacterium tuberculosis (Mtb) requires greater understanding of immune correlates of protection. With renewed interest in BCG as an Mtb vaccine, particularly via the intravenous (IV) route, our objective was to characterize both innate and adaptive immune correlates of vaccine-induced pulmonary immunity as potential biomarkers for protective efficacy in a murine model of Mtb infection. Methods: Mice were given BCG via different routes and some boosted with recombinant virus constructs encoding Mtb Ag85B. Responding innate lymphoid cell (ILC) populations, T cells and B cells were analyzed by fluorescence activated cell sorting (FACS) for surface markers and by …

Corticotropin-Releasing Hormone Modulates Nrem Sleep Consolidation Through The Thalamic Reticular Nucleus, Loredana Cumpana, Olivia Zanoletti, Dinesh Kankanamge, Bryan Copits, Carmen Sandi, Simone Astori

2020-Current year OA Pubs

Corticotropin-releasing hormone (CRH) is a peptide associated with stress and anxiety that acts as a potent modulator throughout the nervous system. The thalamic reticular nucleus (TRN) displays high expression of the CRH receptor 1 (CRHR1), but whether CRH modulates key TRN functions, such as sleep spindle rhythmogenesis, remained unexplored. Combining polysomnographic and photometric recordings in mice, we show that CRH release in TRN during non-rapid-eye movement sleep (NREMS) oscillates with a ~50-s periodicity, anti-correlating with sleep spindle dynamics. Optogenetic manipulations of CRH release in TRN modulated NREMS fragmentation through microarousals with corresponding changes in sigma and delta power. In ex-vivo …

Computer-Automated Systems And Methods For Using Language Models To Generate Text Based On Reading Errors, Scott Sosso, Siyu Chen, Ciara Figliuolo, Jack Mostow, Marlies Goes

AFIT Patents

A computer-implemented system and method generate personalized text based on statistics derived from input received from a user representing the user's attempts to decode graphemes into phonemes. Such statistics may be measured and recorded at the grapheme-phoneme level, and may include substitutions, insertions, deletions, and correct utterances of phonemes by the user when reading text. A language model may be trained based on characteristics of the user, such as the user's age and/or reading grade level, and the personalized text may be generated after such training of the language model. Generating the personalized text may include generating a text creation …

Gm-Csf Production By Immune Cells In Steady State And Autoimmune Neuroinflammation Mapped Using Fate Reporting Mice, Gholamreza Azizi, Javad Rasouli, Hamed Naziri, Michael V. Gonzalez, James Garifallou, Guang-Xian Zhang, Bogoljub Ciric, Abdolmohamad M. Rostami

Department of Neurology Faculty Papers

INTRODUCTION: GM-CSF is a pro-inflammatory cytokine that promotes an inflammatory phenotype in myeloid cells. The extent and pattern of GM-CSF expression in immune cells have not been fully elucidated. Our goal was to advance this topic using novel GM-CSF reporter/fate reporter transgenic mice.

METHODS: We tracked ongoing and past GM-CSF expression in various immune cells from multiple organs, in steady-state and autoimmune inflammation of the central nervous system (CNS).

RESULTS: The GM-CSF expression patterns varied by cell type and organ, with CD4

DISCUSSION: These findings identified distinct GM-CSF cellular sources across organs, highlighting the transient nature of GM-CSF expression and …