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The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

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The Cohort Space As Experienced By Latina Doctoral Students, Tiana Bierwert

Graduate Doctoral Dissertations

This phenomenological study explores how Latina Doctoral Students experience cohort spaces within graduate programs, focusing on the gendered and racialized challenges embedded in these environments. Utilizing pláticas as a culturally grounded method and guided by a Latina Feminist Phenomenological framework, this research examines how cohort models—which are often designed to foster support and collaboration—can instead exacerbate marginalization for students at the intersections of race and gender. Drawing on the conceptual frameworks of White Space and Counterspace, the study interrogates how cohort environments can operate as sites of exclusion and surveillance, where dominant norms are reproduced and where Latina Doctoral Students …

The Speech-To-Song Illusion Across Development And The Effects Of High-Level Expectations, Rodica R. Constantine

UNLV Theses, Dissertations, Professional Papers, and Capstones

The typical listener can readily categorize auditory stimuli as either speech or song even though these structures share many acoustic similarities. These musical and linguistic categories may nevertheless take time to develop as children acquire language- and music-specific knowledge. In the Speech-to-Song (STS) illusion, multiple repetitions of a natural spoken utterance can give rise to a perceptual switch wherein the stimulus begins to sound song-like to the listener. While the STS illusion has been well-researched in adult listeners, it had yet to be investigated in children. In our study, we examined whether children experience the STS illusion by presenting participants …

The Dual Impact Of Moral Injury: Links To Ptsd Symptoms And Disinhibited Externalizing In U.S. Combat Veterans, Bianca S. Islas

UNLV Theses, Dissertations, Professional Papers, and Capstones

Moral injury is an experience of psychological distress that occurs when a person’s morals are violated by themselves or others, including institutions and organizations. Such violations of morality can be impairing and have high rates of comorbidity with internalizing disorders (posttraumatic stress, depression, anxiety, suicidality), which may indicate that moral injury is a transdiagnostic construct. This study had four aims, which were accomplished using from a nationally representative, probability-based sample of 1,353 US military veterans. In the first aim, we created structural models of moral injury using the Moral Injury Events Scale (for which a bifactor structure with a specific …

Development Of An Access Charge Framework For High-Speed Rail Incorporating Rail Replacement Costs And Dynamic Train Characteristics, Nitesh Kumar Yadav

UNLV Theses, Dissertations, Professional Papers, and Capstones

This thesis develops a framework to determine track access charges for shared high-speed rail corridors, with a focus on rail replacement cost driven by train-induced loads. The method explicitly accounts for both static loads, resulting from axle weights, and dynamic loads that arise from train speed and track geometry, particularly curvature. Train characteristics such as axle load, operating speed, frequency of service, and number of wheels are integrated with track parameters, including curve radius, to calculate the total vertical load. These loads are used to estimate the cumulative tonnage threshold for rail replacement and the resulting service life of the …

Outcomes Of Patients With Newly Diagnosed Acute Myeloid Leukemia With Flt3-Tyrosine Kinase Domain Mutations: Prognostic Implications Of Npm1 Co-Mutation, Sankalp Arora, Wei-Ying Jen, Musa Yilmaz, Indraneel Deshmukh, Jayastu Senapati, Sanam Loghavi, Ghayas C Issa, Nicholas J Short, Tapan M Kadia, Courtney D Dinardo, Gautam Borthakur, Joseph Jabbour, Naveen Pemmaraju, Michael Andreeff, Koichi Takahashi, Kapil Bhalla, Uday Popat, Elizabeth J Shpall, Betul Oran, Hussein A Abbas, Guillermo Garcia-Manero, Farhad Ravandi, Hagop Kantarjian, Naval Daver

Faculty, Staff and Student Publications

Background: The prognostic impact of Fms-like tyrosine kinase 3 (FLT3)-tyrosine kinase domain (TKD) mutation in patients with acute myeloid leukemia (AML) is not well defined. The authors described outcomes of one of the largest cohorts of patients with FLT3-TKD mutated (FLT3-TKDmut) AML to date.

Methods: This retrospective study included patients with newly diagnosed AML who received frontline treatment at The University of Texas MD Anderson Cancer Center from January 2012 to March 2024 divided into two cohorts: FLT3-TKDmut AML and nucleophosmin-mutated (NPM1mut)/FLT3-TKD wild-type (FLT3-TKDwt) AML. Patients with FLT3 internal tandem duplication mutations were excluded.

Results: In total, 2922 patients were …

Lipidomic And Proteomic Insights From Extracellular Vesicles In The Postmortem Dorsolateral Prefrontal Cortex Reveal Substance Use Disorder-Induced Brain Changes, Chioma M Okeoma, Wasifa Naushad, Bryson C Okeoma, Carlos Gartner, Yulica Santos-Ortega, Calvin Vary, Savio Lima-Bastos, Victor Corasolla Carregari, Martin R Larsen, Alessio Noghero, Consuelo Walss-Bass, Rodrigo Grassi-Oliveira

Faculty, Staff and Student Publications

Substance use disorder (SUD) significantly increases the risk of neurotoxicity, inflammation, oxidative stress, and impaired neuroplasticity. The activation of inflammatory pathways by substances may lead to reactive astrogliosis and chronic neuroinflammation, potentially mediated by the release of extracellular particles (EPs), such as extracellular condensates (ECs) and extracellular vesicles (EVs). These particles, which reflect the physiological, pathophysiological, and metabolic states of their cells of origin, might carry molecular signatures indicative of SUD. In particular, our study investigated neuroinflammatory signatures in SUD patients by isolating EVs from the dorsolateral prefrontal cortex (dlPFC) Brodmann's area 9 (BA9) from postmortem subjects. We isolated BA9-derived …

Evaluation Of The Antimicrobial Management Of Intracranial Suppurative Infections In A Single Pediatric Institution., Cameron E. Bizal, Alaina N. Burns, Rana El Feghaly, Brian R. Lee, Ann L. Wirtz

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: To describe the antimicrobial management of and examine the etiology of intracranial suppurative infections (ISIs) at a single pediatric institution.

DESIGN: Retrospective review.

PATIENTS: We included children hospitalized at a 367-bed freestanding pediatric institution for treatment of an ISI (epidural or subdural empyema, brain abscess) between January 1, 2015, and September 30, 2023. ISIs were identified using international classification of diseases 9/10 discharge diagnosis codes.

METHODS: We collected data regarding patient characteristics, infection etiology and complications, antimicrobial choice and route (empiric, definitive, and outpatient), microbiology results, treatment duration, and treatment-related outcomes from the electronic health record.

RESULTS: A total …

Randomised, Placebo-Controlled Trial Of Oral Hymecromone In Adults With Pulmonary Hypertension, Kathryn Czepiel, Nadine Nagy, Tamera Panjalingam, Anissa Kalinowski, Adam R Frymoyer, Harry Karmouty-Quintana, Bo Gu, Haley Hedlin, Gernot Kaber, Sylvie Dobrota Lai, Joelle I Rosser, Paul L Bollyky, Vinicio De Jesus Perez, Roham T Zamanian

Faculty, Staff and Student Publications

Background: Pulmonary hypertension (PH) is a progressive cardiopulmonary condition associated with increased morbidity and mortality. The extracellular matrix component hyaluronan (HA) is linked to vascular remodelling and interstitial fibrosis in PH. We hypothesised that inhibition of HA synthesis with hymecromone could serve as a reverse-remodelling therapy in PH.

Methods: We performed a proof-of-concept phase IIa randomised, double-blind, placebo-controlled study in adults with pulmonary arterial hypertension and PH associated with interstitial lung disease (PH-ILD). Patients were randomised to a 5:3 ratio and stratified by PH group to receive oral hymecromone or placebo two times per day over 24 weeks. The primary …

Mathematical Modeling And Association Analysis Decipher The Impact Of The Gut Microbiome On Cancer Immunotherapy, Andreas G Hadjigeorgiou, Constantinos Harkos, Aditya K Mishra, Golnaz Morad, Sarah B Johnson, Nadim J Ajami, Jennifer A Wargo, Lance L Munn, Triantafyllos Stylianopoulos, Rakesh K Jain

Faculty, Staff and Student Publications

The gut microbiome has emerged as a key regulator of response to cancer immunotherapy. However, a better understanding of the underlying mechanisms by which the microbiome influences immunotherapy is needed to identify strategies to optimize outcomes. To this end, we developed a mathematical model to obtain insights into the effect of the microbiome on the immune system and immunotherapy response. This model was based on (i) gut microbiome data derived from preclinical studies, (ii) mathematical modeling of the antitumor immune response, (iii) association analysis of microbiome profiles with model-predicted immune profiles, and (iv) statistical models that correlate model parameters with …

Clinical, Tumor, And Product Features Associated With Outcomes After Axicabtagene Ciloleucel Therapy In Follicular Lymphoma, Soumya Poddar, Jiali Yan, Gayatri Tiwari, Darawan Rinchai, Justin Budka, Wangshu Zhang, Weixin Peng, Shruti Salunkhe, Madison Davis, Qinghua Song, Sara Beygi, Harry Miao, Mike Mattie, Rhine S Shen, Caron A Jacobson, Davide Bedognetti, Simone Filosto, Sattva S Neelapu

Faculty, Staff and Student Publications

Background: Axicabtagene ciloleucel (axi-cel), anti-CD19 chimeric antigen receptor (CAR) T cell therapy, demonstrated remarkable efficacy with manageable toxicity in relapsed/refractory indolent B cell lymphomas in the ZUMA-5 trial.

Methods:Here, we report associations of product attributes, serum biomarkers, clinical features, and tumor characteristics with outcome in 124 patients with follicular lymphoma (FL).

Results: In univariate and multivariate analyses, pretreatment inflammatory markers, including TNF-α and IL-12p40, as well as total metabolic tumor volume (TMTV), associated with disease progression. Conversely, T-naive–like product phenotype associated with improved outcome, particularly in patients with high TMTV. These covariates improved risk stratification when combined with the …

Contemporary Outcomes Of Octa-Nonagenarians With Newly Diagnosed Acute Myeloid Leukemia, Jayastu Senapati, Hagop M Kantarjian, Tapan M Kadia, Jeannot Kekedjian, Gautam Borthakur, Naval Daver, Courtney D Dinardo, Elias Jabbour, Prithviraj Bose, Nicholas J Short, Musa Yilmaz, Nitin Jain, Naveen Pemmaraju, Hussein A Abbas, Ghayas C Issa, Abhishek Maiti, Guillermo Montalban Bravo, Indraneel Deshmukh, Elizabeth Shpall, Partow Kebriaei, Uday Popat, Sanam Loghavi, Beenu Thakral, Guilin Tang, Fadi G Haddad, Yesid Alvarado, Guillermo Garcia Manero, Farhad Ravandi

Faculty, Staff and Student Publications

Background: Octa-nonagenarians with acute myeloid leukemia (AML) represent a high-risk group due to frequently poor performance status, adverse genomics (e.g., TP53 mutations, complex karyotype), a high incidence of secondary AML, and inability to undergo an allogeneic stem cell transplantation. Evaluating their outcomes with modern treatment approaches is important.

Methods: This retrospective study analyzed outcomes of patients ≥80 years old with newly diagnosed AML treated at our center from 2013-2023.

Results: A total of 289 patients (median age, 83 years; range, 80-95 years) were included. Venetoclax containing low-intensity therapy was administered to 107 patients (37.0%). AML subtypes included de novo (123, …

The Experience Of Posttraumatic Growth For Atheists, Savannah Miller

Doctoral Dissertations

Background - This study aimed to understand how atheists manage to make meaning and find growth after experiencing trauma. Posttraumatic Growth is a well documented point of research across qualitative and quantitative domains, and this project aimed to add meaningful findings to that research body. Atheists, however, are an understudied population, especially as it relates to their subjective experience of trauma and posttraumatic growth.

Methods - This study aimed to investigate the experience of posttraumatic growth for atheistindividuals. Semi-structured interviews adhering to the tenets of interpretive phenomenological analysis were conducted then transcribed, coded, and analyzed. Themes and subthemes emerged and …

Biological Control Mitigates Spread Of Vector-Borne Plant Pathogens, Kris A.G. Wyckhuys, Yi Zou, David W. Crowder, Evie Adriani, Annabelle B. Albaytar, Marie Joy B. Beltran, Ibtissem Ben Fekih, Carolina Camargo-Gil, Filomena C. Filomena, Lizette Cicero, Yelitza C. Colmenarez, Claudia M. Cuellar-Palacios, Thomas Dubois, Sanford D. Eigenbrode, Frederic Francis, Alberto Fereres, Khalid Haddi, Fathiya M. Khamis, Cécile Le Lann, Anne Le Ralec, Lorena Lopez, Baoqian Lyu, James Montoya-Lerma, Karen Muñoz-Cardenas, Ihsan Nurkomar, Paola A. Palmeros-Suarez, Jermaine D. Perier, Ricardo Ramírez-Romero

All Peer-Reviewed Publications

Diseases caused by vector-borne plant pathogens cause adverse impacts on yield resilience, food security, and farmer livelihoods, which are bound to aggravate under global change. Biological control is routinely discounted as a mitigation strategy for plant diseases, partially due to scarce and inconclusive empirical support. Here, using curated field survey data for 58 persistently or semi-persistently transmitted pathogens, we employ a multi-method approach to assess the role of resident (i.e., naturally occurring) biological control agents in these pathosystems. Our meta-analyses show how in planta pathogen incidence is strongly affected by vector abundance and infectivity. Meanwhile, biological control agent density negatively …

Role Of Immunosuppressive Jnk Pathway In The Tumor Microenvironment Among Tnbc Subtypes In Ibcsg Trial 22–00, Andrea Joaquin Garcia, Takashi Semba, Mattia Rediti, Daniel J Mcgrail, Xuemei Xie, Xiaoping Wang, Dileep R Rampa, David Venet, Laurence Buisseret, Samira Majjaj, Roswitha Kammler, Marco Colleoni, Sherene Loi, Giuseppe Viale, Meredith M Regan, Françoise Rothé, Christos Sotiriou, Naoto T Ueno

Faculty, Staff and Student Publications

Phosphorylation of the JNK (pJNK) protein promotes an immunosuppressive tumor microenvironment (TME), enhancing aggressiveness in inflammatory triple-negative breast cancer (TNBC). This study evaluated the role of JNK signaling using a gene signature. RNA sequencing was performed on 347 TNBC tumors from the phase 3 International Breast Cancer Study Group (IBCSG) 22-00 trial, which evaluated adjuvant low-dose cyclophosphamide and methotrexate (CM). Immune-related tumors were identified by TNBC subtype or tumor-infiltrating lymphocytes (TILs). Associations between JNK and outcomes were analyzed using Cox models. Low pJNK levels were associated with better disease-free survival (DFS) in immune-related tumors. These tumors also had lower Treg …

Scientist Perspectives: A Correlation Analysis Of Translational Science Competencies Compared With Principles Of Engagement And Knowledge Integration, Rachel Wenzl

Theses & Dissertations

The competencies identified in the development of the “Fundamental Characteristics of the Translational Scientist” may not consider and fully integrate the concepts of knowledge integration and engagement, key components of the translational science spectrum. This gap may be widening and deepening the “valley of death” and exacerbating ongoing challenges in the field of translational science. This dissertation explored the association of knowledge integration, stakeholder engagement, and community engagement principles compared with translational science competencies.

Utilizing content review and a non-experimental, correlation study design, data were collected through a quantitative survey from adult research subjects all self-identified as a research investigator …

Evaluating Current Practices In Operative Nontechnical Skills Training And Feedback In General Surgery Residency: A Mixed Methods Approach, Madeline Cloonan

Theses & Dissertations

Background: Non-technical skills (NTS) are the interpersonal and cognitive abilities that are critical to accomplishing high-risk tasks. Deficiencies in NTS, including communication, teamwork, leadership, and decision-making, are linked to errors in the operating room. Structured training and feedback in NTS remain inconsistent and have not been integrated into daily training. This dissertation addresses this gap by evaluating current NTS training and feedback practices and developing a rubric to enhance the effectiveness of NTS feedback.

Methods: We conducted five complementary studies to assess current NTS training and feedback. The first was a systematic review aimed at identifying intraoperative NTS training interventions …

Colostrum Extracellular Vesicle Are Neuroprotective In The Mptp Intoxicated Mouse Model Of Parkinson's Disease, Samia Akter

Theses & Dissertations

Parkinson’s Disease (PD) is the second most common neurodegenerative disorder. Dopaminergic neuronal loss in the substantia nigra and the formation of Lewy bodies are the disease pathological hallmarks. We demonstrate that bovine colostrum extracellular vesicles (EVs) induce anti-inflammatory and neuroprotective activities during MPTP (methyl-4-phenyl-1,2,3,6-tetrahydropyridine) intoxication. Treatment these mice with colostrum EVs reduced the extent of activated microglia and neurodegenerative activities. RNA sequencing and transcriptomic analysis revealed a significant decrease in pro- inflammatory responses, as well as reduced recruitment and activation of immunocytes in affected brain tissues. Decreased expression of pro-inflammatory cytokines and chemokines, as well as suppressed canonical inflammasomes, was …

Temporal Patterns Of Ectopic Pregnancy: Using The Electronic Health Record To Illuminate A Dark Corner In Women's Health, Kirsten Hepburn

Theses & Dissertations

Ectopic pregnancy remains a significant contributor to pregnancy-related morbidity and mortality, yet little is known about whether its occurrence follows discernible temporal patters that could inform prediction and prevention efforts. This dissertation aimed to explore the temporal characteristics of ectopic pregnancy through three interrelated projects: development of a new theoretical framework, a scoping review of the literature on ectopic pregnancy temporal patterns, and an empirical study using electronic health records data from a ten-year period at a single academic medical center. The Nursing Genomic and epigenomic, Environment, and Microbiome (N-GEM) situation-specific theoretical framework was introduced as a novel nursing theory …

Role Of Stabilin-1 Expressing Macrophages In Colorectal Liver Metastasis, Jampa L. Gurung

Theses & Dissertations

Colorectal cancer (CRC) is the 2nd most common cause of cancer-related mortality, primarily due to its spread to distant organs. Colorectal liver metastasis (CRLM) is the foremost form of CRC spread due to the anatomical link between the liver and intestine. Despite advancements in diagnostic tools and adjuvant therapies, the survival rate of CRLM remains low, indicating the significant need to identify targetable mechanisms. Stabilin-1 (STAB1), a scavenger receptor expressed on tumor-associated macrophages, has been linked to tumorigenesis and poor outcomes in various cancers. However, the role of STAB1 in CRLM is not known. Here, we investigated the role of …

Study Of Peptide Amphiphiles As Antimicrobial Agents, Aramis J. Pereira

Theses & Dissertations

The global antimicrobial resistance (AMR) crisis presents a severe public health threat, with drug-resistant infections now the third leading cause of mortality worldwide. This escalating problem, driven by the rapid proliferation of multidrug-resistant organisms (MDROs) like the "ESKAPE" pathogens, severely limits treatment options and imposes substantial economic burdens. The crisis is further exacerbated by a limited pipeline of new antimicrobial agents, as most recently approved drugs are modifications of existing classes rather than novel compounds. Peptide amphiphiles (PAs) offer a promising alternative due to their membrane-targeting mechanism, which reduces the likelihood of resistance development. These molecules are amphiphilic and positively …

Toddler Meal And Snack Hack Kinyarwanda, Kate Graves

UNH Cooperative Extension

No abstract provided.

Harmful Effects Of The Interaction Between Microplastic Container, Aluminuim Foil And Hot Water On Some Physiological Parameters Using Pigeon Model, Faten S Mounce, Nadheerah F Neamah, Manal N Alhayder

Baghdad Science Journal

Due to common used of disposable food containers cuurrently.This study evaluated the toxicity resulted from the interaction between the boiling tap water, microplastic container , aluminuim foil with or without microwave radiation on some physiological and histological parameters in Pigeons. Forty pigeons were classified into four groups. The birds in group 1 drink tap water without boiling placed in the usual drinking bowl. The birds in group 2 received tap water in thermoplastics containers previously boiled in microwave oven for 5 minutes, whereas in group3, the birds drink boiled tap water that put in thermoplastics containers for 5 min and …

Histochemical Demonstrations Of The Lens Of The Sailfin Molly (Poecilia Latipinna) With Retinal Adaptation, Shaimaa Awad Abid, Mukhtar Khamis Haba

Baghdad Science Journal

The study revealed that histochemical examination of the lens and retina in the fish Poecilia latipinna reflects adaptation and acclimation to dark and light conditions. The tissue sections of the lens and retina were stained with different stains and examined by a light microscope. The lens was found to be spherical in shape, transparent, hard, and avascular. The lens was surrounded by a cellular homogeneous capsule and followed by cuboidal epithelial cell layer, which was situated beneath the capsule. The epithelial cells elongated into lens fibers that were arranged in concentric rings, and the lens fiber membranes took a serrated …

Quantification Of Bioactive Compounds In Coffea Arabica And Their Impact With Omega-3 Supplementation On Non-High-Density Lipoprotein Levels In Hyperlipidemia-Induced Rats, Sojoud M. Al-Zoubi, Shady H. Awwad, Reem A. Issa, Ahmad Q. Daraosheh, Talal Al-Qaisi, Husni Farah, Khaled W. Omari, Beisan A. Mohammad, Mumen Amer, Rula F. Khuzaie, Mahmoud S. Abu-Samak

Baghdad Science Journal

This study aims to evaluate the levels of coffee lipids, diterpenes, chlorogenic acid (CGA), and caffeine in coffee samples with different roasting levels. Additionally, it aims to assess the impact of coffee extracts with/without omega-3 supplementation on lipid profile parameters. Liquid-liquid and soxhlet extraction, and quantitation were performed using HPLC-DAD. Two groups of Wistar rats were used: non-hyperlipidemic and hyperlipidemic. Blood samples were collected before and after hyperlipidemia induction after six weeks. The lipid profile: total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG), non-high-density lipoprotein (non-HDL), and total cholesterol-to-high-density lipoprotein ratio (TC/HDL) were determined. A positive correlation …

Highly Potent And Subtype-Selective Sperm-Specific Potassium Channel Slo3 Inhibitors Display High Tissue Exposure In The Murine Female Reproductive Tract, Kayla J Temple, Ping Li, Maximilian D Lyon, Shweta Bhagwat, Leila Asadi, Sophia Li, Ronald Mccarthy, Celia M Santi, Et Al.

2020-Current year OA Pubs

To date, the study of drug exposure and distribution throughout the female reproductive tract has often been overlooked and neglected. Herein, we report the first highly potent and subtype-selective sperm-specific potassium channel 3 (SLO3) inhibitors as a new modality of contraceptives. After extensive

Estimation Of Paraoxonase-1 And Dipeptidyl Peptidase In Iraqi Prostatic Cancer With Hormones And Chemotherapy Drugs: A Cross-Sectional Study, Ammar H.Al-Qazzaz, Anwar F. Al-Taie

Baghdad Science Journal

Prostate cancer is a frequent masculine disease, especially when becoming older. Paraoxonase-1 (PON-1) is an enzyme present in the human body that plays an important function in preventing oxidative stress and inflammation. It is mostly linked to high-density lipoprotein (HDL). Dipeptidyl peptidase-4 (DPP-4) is an enzyme regulating blood sugar levels. It is found on many cells surfaces: immune cells, epithelial cells, and pancreatic cells. The aim of this cross-sectional study was to determine the biochemical role of PON-1 effect and DPP-4 enzymes with the anti-cancer ability of vitamin D. Research samples were collected from Iraqi prostate cancer patients (male aged …

Evaluating The Selectivity Of Novel Zic-Hilic Columns And An Application For Determining Antihistaminic Drugs In Pharmaceutical Preparations, Ashraf Saad Rasheed, Mustafa J. Mohammed

Baghdad Science Journal

The hydrophilic interaction liquid chromatography (HILIC) conjugated with UV spectrometry was employed to the determination of two antihistaminic drugs (Acrivastine and fexofenadine) in pharmaceutical formulations using two lab-made zwitterionic HILIC stationary phases (ZIC-2 and ZIC-5). The study aimed to investigate the impact of separation parameters including acetonitrile (ACN) content, pH of the eluent, and acetate buffer concentration on the retention behavior of Acrivastine and fexofenadine. A mixture of 3.0 mM acetate buffer (pH 4.75) and ACN (30:70) was used as eluent, with a flow rate of 0.6 mL/min. The detection wavelength was controlled at 267nm. The linearity of Acrivastine and …

Synthesis, Biological Activity And Molecular Docking Study Of Some New Chalcones, 5,6-Dihydropyrimidin-2-Ol And 5,6-Dihydropyrimidin-2-Thiol Derivatives Bearing 1,2,3- Triazoline, Hayder Raheem Ali, Ahmed Wahed Naser

Baghdad Science Journal

Many new chemicals, including chalcones, derivatives of 5,6-dihydropyrimidin-2-ol and 5,6-dihydropyrimidin-2-thiol, are synthesized in this work. The starting materials are substituted acetophenone derivatives involving 1,2,3-triazoline (1). Chalcone derivatives (2a-h) were obtained by condensing compound (1) with some substituted aromatic aldehydes in the presence of 40% potassium hydroxide KOH. The process of producing pyrimidin-2-ol derivatives (3a–e) by cyclizing produced chalcone derivatives (2a–e) urea in the presence of sodium hydroxide. Equivalent pyrimidin-2-thiol derivatives (4a-d) were produced when chalcone derivatives (2a-d) reacted with thiourea in the presence of sodium hydroxide. The …

Normal And Reverse Flow Injection- Spectrophotometric Determination Of Doxycycline Hyclate In Bulk And Pharmaceutical Samples, Tabarak Mohammed, Hind Hadi

Baghdad Science Journal

The present paper reports the development and validation of an analytical method for doxycycline hyclate (DOX) quantification in pure and dosage forms by normal and reverse flow injection analysis (FIA) techniques. Two types of FIA approaches were employed to automate a diazotization coupling reaction of DOX with diazotized benzidine dihydrochloride. Red azo dye was formed rapidly and measured at maximum wavelength of 488 nm. Calibration curves were prepared over different DOX concentrations with linearity ranges of 10-250 and 1-180 µg/mL for normal and reverse FIA systems respectively with the limits of detection of 2.95 and 0.46 µg/mL and limits of …