Digital Commons Network^™

Phytochemical Analysis And Appraisal Of Antiproliferative Activity Of Magnolia Alejandrae, José E. Caballero-Chávez, Alma D. Paz-Gonzalez, Diana V. Navarrete-Carriola, Fabian E. Olazarán, María Miriam Estevez-Carmona, Benjamin Nogueda-Torres, Fernando Emiliano Jiménez-Mondragón, Melany X. Márquez-Aguilar, Carmen Michelle Pineda-Alcala, Debasish Bandyopadhyay

School of Integrative Biological & Chemical Sciences Faculty Publications

Background: Magnolia alejandrae is a tree endemic to Tamaulipas, Mexico, distributed in the forests of the Sierra Madre Oriental. Objective: Our objective was to analyze the secondary metabolite profile of different parts of M. alejandrae and evaluate their antiproliferative activity in vitro. Methods: Different extracts of leaf, bark, and fruit were obtained using conventional and unconventional extraction methods with solvents of different polarity. The extracts were analyzed by Ultra-Performance Liquid Chromatography-Mass Spectra (UPLC-MS), and their antiproliferative activity against cancer cell lines was determined. Results: The primary yields of the extracts obtained from M. alejandrae ranged from 8.32% to 36.19%. Three …

Re: Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites Field Sampling And Investigation Plan (Fsp): Bres No. 91 – Robert Emmett Dumps, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Β-Catenin Functions As A Molecular Adapter For Disordered Cbaf Interactions, Yuen San Chan, Qinyu Gao, Sarah A Robinson, Wenzhi Wang, Ruzena Filandrova, Lisa-Maria Weinhold, Mario Loeza Cabrera, Miao Zhang, Chandra Shekar R Ambati, Antonio M Lerario, Nagireddy Putluri, Katja Kiseljak-Vassiliades, Margaret E Wierman, Mouhammed Amir Habra, Gary D Hammer, Vaclav Veverka, Katerina Cermakova, H Courtney Hodges

Faculty, Staff and Students Publications

BAF (SWI/SNF) chromatin remodelers engage binding partners to generate site-specific DNA accessibility. However, the basis for interaction between BAF and divergent binding partners has remained unclear. Here, we tested the hypothesis that scaffold proteins augment BAF's binding repertoire by examining β-catenin (CTNNB1) and steroidogenic factor 1 (SF-1, NR5A1), a transcription factor central to steroid production in human cells. BAF inhibition rapidly opposed SF-1/β-catenin enhancer occupancy, impairing SF-1 target activation and SF-1/β-catenin autoregulation. These effects arise due to β-catenin's role as a molecular adapter between SF-1 and an intrinsically disordered region (IDR) of the canonical BAF (cBAF) subunit ARID1A. In contrast …

Investigation Of A Stable And Saturated Reference Electrode Using Metal Chlorides And Oxides In Eutectic Licl-Kcl Molten Salts, Carlos Mejia, Devin Rappleye

Faculty Publications

Stable and reproducible reference electrodes (REs) are essential for electrochemical systems operating in high-temperature molten salts, where consistent control of potential is required. This study uses three different solutes to investigate the development and evaluation of REs in eutectic LiCl-KCl at 773 K. The solutes tested were NiCl₂, AgCl, and NiO, each prepared at multiple concentrations to assess stability, reproducibility, and saturation. Electrochemical stability was measured over three days using chronopotentiometry (CP), followed by open circuit potential (OCP), with cyclic voltammetry (CV) also integrated to monitor changes in electrochemical behavior over time. The CP-OCP approach established a Li …

Implementation Of Culturally Relevant Pedagogy In Elementary Reading Instruction, Chelsea Renae Little

Walden Dissertations and Doctoral Studies

Culturally relevant pedagogy (CRP) has been shown to help educators address the unique educational needs of African American students. While research has supported the belief that CRP promotes a sense of belonging and positively influences academic achievement, there remains a lack of research regarding elementary teachers’ perceptions of their implementation of CRP specifically when teaching reading to African American students. Framed by Ladson-Billings’s CRP framework, the purpose of this basic qualitative study was to explore elementary teachers' perceptions of their implementation of CRP when teaching reading to African American students. Using a basic qualitative design, data were collected through semistructured …

Comparative Modeling Of Nuclear Energy Consumption In The United States And France: An Optimized Structure-Adaptive Grey Model, Alae Chahid '25, Naima Shifa

Student Research

This study investigates nuclear energy consumption trends in the United States, and France by applying advanced time-series modeling and computational optimization techniques. Using annual consumption data from 2005 to 2023, the research compares the predictive accuracy under data scarcity of the AutoRegressive Integrated Moving Average (ARIMA), Grey Model (1,1,t), Grey Model(1,1,t²), and an Optimized Structure-Adaptive Grey Model (OSGM). This OSGM (1,1,_) the traditional Grey Model (1,1) by introducing time-dependent terms and parameter tuning through particle swarm optimization and Monte Carlo simulations. Models are trained and tested using an in-sample and out-of-sample period framework. Then, forecast accuracies are compared using Mean …

Homelessness Among School-Aged Children In The Mountain West, 2022-2023, Mohit Pande, Sean Curry, Olivia K. Cheche, Caitlin J. Saladino, William E. Brown Jr.

K-12 Education

This fact sheet presents data on homelessness among school-aged children in the Mountain West during the 2022-2023 school year. The data are sourced from the “Child and Youth Homelessness in the United States: Data Profiles” dashboard produced by SchoolHouse Connection and Poverty Solutions at the University of Michigan. State-level data profiles include information about child and youth homelessness at the national, state, county, school district, and congressional district levels. This fact sheet focuses on homelessness among school-aged children within the Mountain West states of Arizona, Colorado, Nevada, New Mexico, and Utah.

Public School Funding In The Mountain West, 2020-2021, Sean Curry, Mohit Pande, Olivia K. Cheche, Caitlin J. Saladino, William E. Brown Jr.

K-12 Education

This fact sheet examines the state of public school funding across the five Mountain West states of Arizona, Colorado, Nevada, New Mexico, and Utah. The data are sourced from the Education Law Center’s 2023 Making the Grade report, which provides data for all 50 U.S. states and the District of Columbia. The original report provides grades for school funding, enrollment data, and funding data based on the 2020-2021 school year.

Biodegradable Nanocomposites Thin Films For Recyclability Electronic Covering, Ban Jawad, Ammar Emad Al-Kawaz, Hanaa Jawad, Nabeel Hasan, Balqees Mohammed

Baghdad Science Journal

In this study, the nanocomposite thin films were prepared from polyvinyl alcohol (PVA) that reinforced with different proportions of carbon nanotubes (CNTs) via hand casting method . The current work aims to create the connection between improving surface characteristics for high efficiency electronic covering and biodegradability. The nature of bonding between the PVA and CNTs were studied by Fourier-transform infrared spectroscopy (FTIR). Wettability properties were studied via contact angle analyzer. The two dimensions' morphology of nanocomposites was studied using atomic force microscopy (AFM). Biodegradable tests of nanocomposites were performed via burial in soil for seven days. According to the contact …

Statistical Analysis Of Multi-Endpoint Phenotypic Screening Increases Sensitivity Of Planarian Neurotoxicity Testing, Danielle Ireland, L. J. Word, Eva-Maria S. Collins

Biology Faculty Works

There is an urgent need for high-throughput screening (HTS) models to replace, refine, and/or reduce (“3Rs”) vertebrate toxicity testing. Replacing in vivo animal studies is challenging for neurotoxicity and developmental neurotoxicity (DNT), where the functional relevancy of adverse outcomes needs to be assessed on the whole organism. We previously screened the NTP 87-compound library (NTP87), consisting of known and suspected developmental neurotoxicants, and showed that planarian HTS can identify known (developmental) neurotoxicants. Because analysis methods can impact screening results, and our original analysis used the lowest-observed-effect-level (LOEL) only, we hypothesized that the use of state-of-the-art statistical analysis would increase the …

Biogenic Synthesis And Characterization Of Metal Oxides Nanostructures Using Plant-Mediated Extracts Via Green Microwave-Assisted Method, Sahar Ismael Imran

Baghdad Science Journal

Two simple innovative green methods have been developed to synthesize precise phase of cobalt oxide nanostructures Co₃O₄; the first method included using cobalt hydroxide carbonate (extra pure) Co₂CO₃(OH)₂ with aqueous plants extract of syzygium aromaticum (clove) bud extract (SABE) once; then again with pomegranate peel extract (PPE) both samples were submitted to microwave irradiation for 5 minutes followed by discrete calcination at 500 ^oC and then 850 ^oC an interested shapes of doted semi-cubic of Co₃O₄-NPs was successfully obtained in both cases; the samples …

Dragon Guitars And Sexy Zombies: Tracing The Meta-Motion Of The Naga Motif In Northeast Thailand, Aaron Michael Stanley

Dartmouth College Master’s Theses

Abstract

This thesis traces the evolving symbolism of the Naga motif (a mythic water serpent) in Northeast Thailand through a framework I call meta-motion, which maps symbolic persistence of this cultural signifier and boundary marker across four cultural horizons—animist (Z), Hindu–Khmer (B), Buddhist (A), and modern/global (C). Like electrons in quantum super position, symbolic motifs circulate as overlapping “waves” of potential meaning and are concretized into cultural “particles” only when recruited for specific ritual, commercial, or political purposes. I add a bookend extension to Chang’s Hindu-Buddhist (B/A) typology with the addition of Horizons Z and C in order to make …

Implementation Of Patient-Centered Approaches To Enhance Engagement And Satisfaction In Psychiatric Care Within A Family Mental Health Service, Nnenna Attah

Walden Dissertations and Doctoral Studies

Summary I conducted this evaluation of a quality improvement initiative at a family mental health service center aimed to enhance patient engagement and satisfaction in psychiatric care through patient-centered approaches. The practice problem addressed in this project was the lack of patient engagement and satisfaction. This issue is critical to address within the context of nursing practice because patient-centered care is fundamental to improving clinical outcomes, patient satisfaction, and overall quality of care. The practice-focused question was: How can patient-centered approaches enhance patient engagement and satisfaction in psychiatric care? In the project, I focused on evaluating the impact of patient-centered …

Riparian Restoration Increases Soil Microbial Biomass In Marin County Rangelands, But Soil Carbon Stock Is Less Responsive, Sherilyn Kathryn Reinhart

Master's Theses

Land use change has caused the degradation of 70% of the Earth’s soils, directly altering soil microbial communities and carbon cycling. Interest in carbon farming practices is growing, but studies that document the nuances of soil carbon flux in specific bioregions are still too few. In this study, I examined how one practice, riparian restoration, alters soil carbon stock and microbial community structure over time. Using a paired sampling time series design, I collected soil samples from twelve riparian forests and adjacent rangelands near Marin County, California. Young and mature sites ranged from five to 29 years since restoration, and …

Humanizing Cities As An Approach For Solving Cities' Problems To Be More Livable, Kareem Mahrous Ali

Mansoura Engineering Journal

Most people around the world want to move from the countryside to the cities or from one city to another that provides them with all their human needs for a better life. The dream may come true for them or turn into a nightmare for reasons related to general problems facing most cities in the world, such as the high cost of living and the absence of social justice, these problems cause an increase in poor families, or the issue of refugees and the inability of some cities to welcome them, the energy crisis, and the challenges of climate change …

Association Of Glucagon-Like Peptide-1 Receptor Agonists With Cancer Risk In Older Adults With Type 2 Diabetes, Ying Lu, Hao Dai, Huilin Tang, William T Donahoo, Thomas J George, Ramon C Sun, Sizun Jiang, Aik Choon Tan, Yi Guo, Jonathan D Licht, John M Allen, Kelvin P Lee, Jingchuan Guo, Jiang Bian

Faculty, Staff and Student Publications

Objective: The real-world evidence on the association between glucagon-like peptide-1 receptor agonists (GLP-1RAs) and cancer risk remains limited and mixed.

Methods: In 2013-2020 national Medicare claims data, we included cancer-naïve patients with type 2 diabetes (T2D). We identified those who initiated GLP-1 RA, sodium-glucose cotransporter 2 inhibitor (SGLT2i), or dipeptidyl peptidase 4 inhibitor (DPP4i) and conducted 1:1 propensity score matching for confounding adjustment. Cox proportional hazards models were used to estimate hazard ratios (HR) of nine obesity-associated cancers (thyroid, pancreatic, bladder, colorectal, lung, kidney, breast, endometrial, and prostate cancer).

Results: In the matched GLP-1RA versus SGLT2i cohort (n = 21,362 …

Organizational Climate And Decision Aid Sustainability In Lupus Care: Mixed Methods Study, Aizhan Karabukayeva, Larry R Hearld, Nathan W Carroll, Reena Kelly, Jasvinder A Singh

Faculty, Staff and Students Publications

Background: Digital decision aids (DAs) are increasingly used in health care to support shared decision-making and promote patient engagement. In the context of systemic lupus erythematosus (SLE), a complex autoimmune disease characterized by diverse symptoms and uncertain prognoses, DAs offer guidance to patients in navigating treatment risks and benefits. Although numerous studies have examined the initial implementation of evidence-based tools, there is limited evidence on the organizational factors that influence their long-term sustainability in clinical practice. This gap is particularly salient for digital interventions, where integration into routine workflows and ongoing use require alignment with clinic readiness and culture. This …

Investigation Of A Stable And Saturated Reference Electrode Using Metal Chlorides And Oxides In Eutectic Licl-Kcl Molten Salts, Carlos Mejia, Devin Rappleye

Faculty Publications

Stable and reproducible reference electrodes (REs) are essential for electrochemical systems operating in high-temperature molten salts, where consistent control of potential is required. This study uses three different solutes to investigate the development and evaluation of REs in eutectic LiCl-KCl at 773 K. The solutes tested were NiCl2, AgCl, and NiO, each prepared at multiple concentrations to assess stability, reproducibility, and saturation. Electrochemical stability was measured over three days using chronopotentiometry (CP), followed by open circuit potential (OCP), with cyclic voltammetry (CV) also integrated to monitor changes in electrochemical behavior over time. The CP-OCP approach established a Li+/Li redox potential, …

Dclk1 Isoform (Dclk1-S) As A Critical Player In Promoting Inflammation, Tissue Remodeling, And Emt In Mouse Models Of Colitis., Kafayat Yusuf, Badal C. Roy, William L. Hauser, Mazin Al-Kasspooles, Sierra Sanchez, Thomas M. Attard, Dong Pei, Venkatesh Sampath, Shrikant Anant, Shahid Umar

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND AND AIMS: The Doublecortin-like kinase-1 (DCLK1) plays a chemosensory role in the gut. It's role in the context of inflammatory diseases including inflammatory bowel disease (IBD), has not been thoroughly investigated. This study explored the role of the DCLK1 isoform (DCLK1-S) in promoting infectious/chemical colitis by utilizing high-throughput imaging mass cytometry (IMC).

METHODS: Transgenic mice were either infected with Citrobacter rodentium (CR) or received DSS and tissues/cells were processed via standard techniques. IMC workflow was adapted by Fluidigm (renamed Standard BioTools). Raw data was fed to Multiplexed Cell Dataset (MCD) Viewer for image generation and analyzed via histoCAT. Promoters …

Prefrontal Cortex Astrocytes Modulate Distinct Neuronal Populations To Control Anxiety-Like Behavior, Eunyoung Kim, Hairuo Du, Yanqi Tan, Brandon L Brown, Yaowen Chang, Blanca Díaz-Castro, Jonathan V Sweedler, Xinzhu Yu

Faculty, Staff and Student Publications

Accumulating evidence has supported diverse regulatory functions of astrocytes in different neural circuits as well as various aspects of complex behaviors. However, little is known about how astrocytes regulate different neuronal subpopulations that are linked to specific behavioral aspects within a single brain region. Here, we show that astrocytes in the medial prefrontal cortex (mPFC) encode anxiogenic environmental cues in freely behaving mice. Silencing mPFC astrocyte Ca

Phase 1/2 Trial Of Encorafenib, Cetuximab, And Nivolumab In Microsatellite Stable Brafv600e Metastatic Colorectal Cancer, Van K Morris, Christine M Parseghian, Vahid Bahrambeigi, Nourhan Abdelfattah, Lianchun Xiao, Anjali Agrawal, Kangyu Lin, Kanwal P S Raghav, Robert A Wolff, Arvind Dasari, Ryan W Huey, Bryan K Kee, Michael J Overman, Jason A Willis, Phat H Le, Michelle Escano, Yunyu C Baig, Kelsey Pan, David Menter, Alda L Tam, Wai C Foo, Li Shen, Hey Min Lee, Thomas D Gallup, Cori Margain, Dave Gallup, Kimal I Rajapakshe, Paola A Guerrero, Jing Wang, Ryan B Corcoran, Anirban Maitra, Kyuson Yun, Scott Kopetz

Faculty, Staff and Student Publications

The BRAF inhibitor encorafenib and anti-epidermal growth factor receptor (EGFR) antibody cetuximab modestly improve survival for patients with microsatellite stable (MSS) BRAFV600E metastatic colorectal cancer (mCRC), characterized by higher immune activation than MSS BRAFwild-type colorectal cancer (CRC). In this phase 1/2 study (NCT04017650) of 26 participants with MSS BRAFV600E mCRC who received encorafenib, cetuximab, and anti-PD-1 antibody nivolumab, we report an overall response rate of 50% (95% confidence interval [CI] 29–71) and median progression-free survival of 7.4 months (95% CI, 5.6–9.6). Transcriptomic profiling of pretreatment biopsies and extracellular vesicle RNA (evRNA) isolated from plasma show …

Large-Scale Flood Detection And Mapping In The Yangtze River Basin (2016–2021) Using Convolutional Neural Networks With Sentinel-1 Sar Images, Xuan Wu, Zhijie Zhang, Wanchang Zhang, Bangsheng An, Zhenghao Li, Rui Li, Qunli Chen

Environment and Society Faculty Publications

Synthetic Aperture Radar (SAR) technology offers unparalleled advantages by delivering high-quality images under all-weather conditions, enabling effective flood monitoring. This capability provides massive remote sensing data for flood mapping, while recent rapid advances in deep learning (DL) offer methodologies for large-scale flood mapping. However, the full potential of deep learning in large-scale flood monitoring utilizing remote sensing data remains largely untapped, necessitating further exploration of both data and methodologies. This paper presents an innovative approach that harnesses convolutional neural networks (CNNs) with Sentinel-1 SAR images for large-scale inundation detection and dynamic flood monitoring in the Yangtze River Basin (YRB). An …

Full-Stack Quantum Computing, Benjamin C A Morrison

Physics & Astronomy ETDs

Quantum computing is a promising tool for solving computational problems in several areas, including the simulation of physical and chemical systems. The design of practical quantum computing systems for these applications is a daunting task, requiring collaborative work by interdisciplinary teams considering different abstractions of the same systems. This dissertation presents work on the development of those abstractions, and on components that bridge multiple layers of abstraction. I first provide an introduction to quantum circuit model computation, error correction with stabilizer codes, and physics simulation algorithms. In joint work with the QSCOUT software team, I then describe the development of …

Circzfr/Ythdf3 Axis Drives Lymph Node Metastasis In Cervical Cancer Via Fasn Translation, Mingyi Zhou, Yan Gao, Yong Zhang, Lian He, Bo Gao, Yue Zhang, Francois X Claret, George A Calin, Danbo Wang

Faculty, Staff and Student Publications

Background: Lymph node metastasis is a key driver of poor outcomes in cervical cancer. However, the molecular mechanisms of circular RNAs (circRNAs) driving cervical cancer lymph node metastasis remain unclear.

Methods: We identified circZFR, fatty acid synthase (FASN) and YTH N6-methyladenosine RNA binding protein F3 (YTHDF3) protein expression in the cervical cancer patients with long and short disease-free survival (DFS). Functional experiments were performed to investigate the function of circZFR, FASN and YTHDF3 on cell migration and invasion. MeRIP-qPCR, RNA pulldown, RNA Immunoprecipitation (RIP), and Co-Immunoprecipitation (Co-IP) assays were executed to investigate the mechanism of circZFR regulating FASN protein expression. …

Human Interpretable Grammar Encodes Multicellular Systems Biology Models To Democratize Virtual Cell Laboratories, Jeanette A I Johnson, Daniel R Bergman, Heber L Rocha, David L Zhou, Eric Cramer, Ian C Mclean, Yoseph W Dance, Max Booth, Zachary Nicholas, Tamara Lopez-Vidal, Atul Deshpande, Randy Heiland, Elmar Bucher, Fatemeh Shojaeian, Matthew Dunworth, André Forjaz, Michael Getz, Inês Godet, Furkan Kurtoglu, Melissa Lyman, John Metzcar, Jacob T Mitchell, Andrew Raddatz, Jacobo Solorzano, Aneequa Sundus, Yafei Wang, David G Denardo, Andrew J Ewald, Daniele M Gilkes, Luciane T Kagohara, Ashley L Kiemen, Elizabeth D Thompson, Denis Wirtz, Laura D Wood, Pei-Hsun Wu, Neeha Zaidi, Lei Zheng, Jacquelyn W Zimmerman, Jude M Phillip, Elizabeth M Jaffee, Joe W Gray, Lisa M Coussens, Young Hwan Chang, Laura M Heiser, Genevieve L Stein-O'Brien, Elana J Fertig, Paul Macklin

Faculty, Staff and Student Publications

Cells interact as dynamically evolving ecosystems. While recent single-cell and spatial multi-omics technologies quantify individual cell characteristics, predicting their evolution requires mathematical modeling. We propose a conceptual framework-a cell behavior hypothesis grammar-that uses natural language statements (cell rules) to create mathematical models. This enables systematic integration of biological knowledge and multi-omics data to generate in silico models, enabling virtual "thought experiments" that test and expand our understanding of multicellular systems and generate new testable hypotheses. This paper motivates and describes the grammar, offers a reference implementation, and demonstrates its use in developing both de novo mechanistic models and those informed …

2025-08-21 Faculty Senate Meeting Minutes (First Meeting Of The Adams Administration), Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate meeting minutes from August 21, 2025. The first meeting of Dr. Adams' administration.

2025-08-21 Faculty Senate Meeting Minutes (Last Meeting Of The Lennex Administration), Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate meeting minutes from August 21, 2025. The last meeting of Dr. Lennex's administration.

2025-08-21 Faculty Senate Scoop Newsletter, Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate Scoop newsletter from August 21, 2025.

2025-08-21 Faculty Senate Newsletter, Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate newsletter from August 21, 2025.

Objective Performance Status: Enhancing Cancer Patient Fitness Assessment With Wearable Technology., Joseph Mccollom Do, Mazie Tsang

PCI Publications and Projects

Research output: Contribution to journal › Editorial › peer-review