Digital Commons Network^™

Dissection Of Surface Area-Dependent Lipolysis At A Single Organelle Level, Chengxin Ma, Yan Liang, Xinmeng Che, Yuqi Li, Jin Wu, Li Xu, Hongyuan Yang, Tong-Jin Zhao, Feng-Jung Chen, Peng Li

Faculty, Staff and Student Publications

Lipid droplets are dynamic organelles whose size and number signify their role in energy. However, owing to cellular heterogeneity and technological limitations, the relationship between the lipolytic ability and lipid droplet morphology is unclear. Here, we developed a live-cell imaging assay using geometric analysis to quantify cellular lipolysis at a single organelle level, designated imaging lipolysis. Using imaging lipolysis and super-resolution imaging, we found that lipolysis is controlled by both lipase-accessible lipid droplet surface area and lipase activity. Moreover, lipid droplet fusion regulatory proteins CLSTN3β/CIDEs promote lipolysis by increasing the total lipid droplet surface area-to-volume ratio in biophysical regulation. We …

Suppression Of Cardiac Allograft Vasculopathy By A Macrophage Efferocytosis Receptor, Sahil Shah, Aparnaa Ananthakrishnan, Matthew Deberge, Kristofor Glinton, Rebecca T L Jones, Mallory Filipp, Ivana Shen, Joey Lockhart, Connor W Lantz, Edward B Thorp

Faculty, Staff and Student Publications

Cardiac allograft vasculopathy remains a major cause of late morbidity following heart transplantation. While accumulating evidence implicates innate macrophages in the inflammatory progression of CAV, the underlying mechanisms remain incompletely understood. In murine models of CAV, we identified proteolytic cleavage of MERTK, a key anti-inflammatory receptor on macrophages, as a contributing factor to CAV progression. In a model of CAV, MERTK deficiency accelerated allograft rejection and increased intimal leukocyte infiltration. In contrast, mice expressing a genetically cleavage-resistant form of MERTK (MertkCR/CR) exhibited prolonged graft survival, reduced intimal thickening, diminished immune cell infiltration, and decreased circulating effector T cells. …

Outcomes Of Brexucabtagene Autoleucel In Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia With Cns Involvement, Ibrahim N Muhsen, Gregory W Roloff, Rawan Faramand, Tamer Othman, Yannis Valtis, Noam E Kopmar, Simone E Dekker, Matthew Connor, Santiago Mercadal, Timothy E O'Connor, Kaitlyn C Dykes, Mohamed Ahmed, Nikeshan Jeyakumar, Amy Zhang, Katharine Miller, Katherine C Sutherland, Caitlin Guzowski, Vishal K Gupta, Navneet Majhail, Minoo Battiwalla, Melhem M Solh, Shahbaz A Malik, John Mathews, Caspian H Oliai, Paul Shaughnessy, Luke Mountjoy, Catherine J Lee, Aaron C Logan, Stephanie B Tsai, Jessica T Leonard, Marc Schwartz, Joshua P Sasine, Muthu Kumaran, Noelle Frey, Jae H Park, Divya Koura, Ryan D Cassaday, Bijal D Shah, Ibrahim Aldoss, Lori S Muffly, Laquisa C Hill

Faculty, Staff and Students Publications

Patients with relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL) with central nervous system (CNS) involvement (CNS B-ALL) have poor outcomes and were frequently excluded from CD19-targeting chimeric antigen receptor (CAR) T-cell clinical trials. The efficacy and safety of brexucabtagene autoleucel (brexu-cel) in adults with R/R B-ALL was established by the ZUMA-3 trial, which excluded patients with advanced or symptomatic CNS involvement. In this retrospective multicenter analysis, we investigated the safety and efficacy of brexu-cel in patients with CNS B-ALL using data from the ROCCA (Real-World Outcomes Collaborative for CAR T in ALL) consortium. Of 189 patients who received infusion, 31 …

Evaluating The Efficacy And Safety Of Milrinone For Prevention Of Post-Patent Ductus Arteriosus Closure Syndrome (The Midas Trial) In Extremely Preterm Infants: A Multicentre, Double-Masked, Randomised, Placebo-Controlled Trial, Patrick J Mcnamara, Valerie Y Chock, Adrianne Rahde-Bischoff, Jenna Gabrio, Karen J Johnson, Heidi M Harmon, Diana Montoya-Williams, Tarah T Colaizy, Anup C Katheria, Felix Ines, Keira Sorrells, Cheryl Battersby, Philip T Levy, Matthew A Rysavy, Shazia Bhombal, Matthew M Laughon, Ben Carper, Susan R Hintz, Abhik Das, Edward F Bell

Faculty, Staff and Student Publications

Introduction: Post-ligation cardiac syndrome (PLCS) represents a state of severe post-intervention cardiopulmonary instability, seen in up to 50% of extremely premature infants after surgical closure of the patent ductus arteriosus (PDA); yet an evidence-based approach to treatment of this condition does not exist. The objective of this study is to determine the efficacy and safety of prophylactic milrinone in reducing incidence of PLCS and/or mortality within the first 7 days following PDA closure. The central hypothesis is that administration of intravenous milrinone will reduce the incidence of PLCS or death within 7 days of PDA closure either by percutaneous device …

The Role Of Recruited Adipose Stromal Cells And Their Fibroblastic Differentiation In Cancer, Lingyi Cai, Mikhail G Kolonin, Dimitris Anastassiou

Faculty, Staff and Student Publications

Adipose stromal cells (ASCs) are perivascular mesenchymal progenitors of adipose tissue. In cancer patients, ASCs can mobilize and migrate to the tumor, where they subsequently play an important role in cancer progression. This biological process involves the conversion of recruited ASCs into cancer-associated fibroblasts (CAFs). ASC-derived CAFs influence the tumor microenvironment through extracellular matrix remodeling, vascularization, and immunomodulation. These and other processes mediated by secreted paracrine factors also affect gene expression in carcinoma cells to promote the epithelial-mesenchymal transition (EMT), metabolic adaptation, survival, and invasiveness of cancer cells. ASC-derived CAFs can enhance tumor aggressiveness, accounting in part for the link …

Reproducibility Of Statistically Significant Phase Iii Oncology Trials: An In Silico Meta-Epidemiological Analysis, Alexander D Sherry, Pavlos Msaouel, Avital M Miller, Timothy A Lin, Joseph Abi Jaoude, Ramez Kouzy, Adina H Passy, Tomer Meirson, Nikolaos Ignatiadis, Zachary R Mccaw, Erik Van Zwet, Ethan B Ludmir

Faculty, Staff and Student Publications

Purpose: The conventional assumption that P values ≤ 0.05 imply reproducible effects has come under recent criticism. This concern is particularly relevant in oncology, as phase III oncology trials, which directly inform practice, are usually not repeated. Using advanced modeling techniques, we investigated the relationship between P values and reproducibility in oncology.

Methods: We obtained the signal-to-noise ratio distribution in phase III oncology using outcomes from 632 two-arm superiority trials enrolling 496,219 patients. With this distribution, we estimated successful replication probability as the probability that a replicate trial, having the same design, effect size, and standard error, would have a …

Murmurations Of Modular Forms And P-Power Coefficients, Debanjana Kundu, Katharina Müller

School of Mathematical & Statistical Sciences Faculty Publications

We extend the work of N. Zubrilina on murmuration of modular forms to the case when prime-indexed coefficients are replaced by squares of primes. Our key observation is that the shape of the murmuration density is the same.

Re: 2025 Spring Migration Seasonal Report For Berkeley Pit Waterfowl Protection Plan, Mark Thompson, Loren Burmeister

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Re: Approval Letter For Bpsou Blacktail Creek Riparian Actions Draft Field Work Plan: Wetlands Delineation And Functional Assessment (Received August 8, 2025), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Phosphorylation Toggles The Sars-Cov-2 Nucleocapsid Protein Between Two Membrane-Associated Condensate States, Bruna Favetta, Huan Wang, Jasmine Cubuk, Arjun Singh, Mayur Barai, Cesar Ramirez, Haiyan Zheng, Adam J Gormley, N Sanjeeva Murthy, Gregory Dignon, Andrea Soranno, Zheng Shi, Benjamin S Schuster

2020-Current year OA Pubs

The Nucleocapsid protein (N) of SARS-CoV-2 plays a critical role in the viral lifecycle by regulating RNA replication and by packaging the viral genome. N and RNA phase separate to form condensates that may be important for these functions. Both functions occur at membrane surfaces, but how N toggles between these two membrane-associated functional states is unclear. Here, we reveal that phosphorylation switches how N condensates interact with membranes, in part by modulating condensate material properties. Our studies also show that phosphorylation alters N's interaction with viral membrane proteins. We gain mechanistic insight through structural analysis and molecular simulations, which …

Defrnd: Detergent-Free Reconstitution Into Native Nanodiscs With Designer Membrane Scaffold Peptides, Qian Ren, Vinay Idikuda, Baron Chanda, Et Al.

2020-Current year OA Pubs

Membrane scaffold protein-based nanodiscs have facilitated unprecedented structural and biophysical analysis of membrane proteins in a near-native lipid environment. However, successful reconstitution of membrane proteins in nanodiscs requires prior solubilization and purification in detergents, which may impact their physiological structure and function. Furthermore, the detergent-mediated reconstitution of nanodiscs is unlikely to recapitulate the precise composition or asymmetry of native membranes. To circumvent this fundamental limitation of traditional nanodisc technology, we herein describe the development of membrane-solubilizing peptides to directly extract membrane proteins from native cell membranes into nanoscale discoids. By systematically protein engineering and screening, we create a class of …

Danicamtiv Reduces Myosin's Working Stroke But Activates The Thin Filament By Accelerating Actomyosin Attachment, Brent Scott, Lina Greenberg, Caterina Squarci, Kenneth S Campbell, Michael J Greenberg

2020-Current year OA Pubs

Heart failure is a leading cause of death worldwide, and even with current treatments, the 5-y transplant-free survival rate is only ~50 to 70%. As such, there is a need to develop new treatments for patients that improve survival and quality of life. Recently, there have been efforts to develop small molecules for heart failure that directly target components of the sarcomere, including cardiac myosin. Danicamtiv is one of these molecules; however, its direct effects on myosin's single molecule mechanics and kinetics are not well understood. Using optical trapping techniques, stopped flow transient kinetics, and in vitro reconstitution assays, we …

Effects Of Ambient Temperature On Nox Emissions From Heavy-Duty Diesel Vehicles Measured In Utah, Amber L. Gurecki Allen, Darrell B. Sonntag, Gary A. Bishop

Fuel Efficiency Automobile Test Publications

This study investigates the effects of ambient temperature on NOx (NO + NO2) emissions from model year 2011 and later heavy-duty (HD) diesel vehicles. Emission measurements were collected in Perry, Utah, using the Fuel Efficiency Automobile Test (FEAT) remote sensing device. Data were limited to model year 2011 and later to focus on vehicles likely equipped with selective catalytic reduction (SCR) systems, which control tailpipe NOx emissions and are shown to be temperature sensitive. HD diesel vehicles measured in the winter of 2020 had consistently higher NOx emissions than those measured in the summer of 2023, most significantly for vehicles …

Reforming The Indian Bar: The Limits Of Technological Solutions, Varsha Aithala, Karthik Suresh

Articles

A majority of Indians do not have effective access to legal services, despite the constitutional promise of access to justice. There are two intertwined reasons for this: the unavailability of a sufficient number of good quality lawyers, and the high costs of accessing legal services. The Indian legal profession is highly unequal, with ‘prestige’ being the currency of upward professional mobility. The professional regulator, the Bar Council of India, simply lacks the capacity to regulate quality. As a consequence, clients lack the information to access lawyers, and to understand the outcomes they desire from them, and the fees they have …

37th Convocation Pakistan

Speeches from convocations, inaugurations, and major events

No abstract provided.

'What The World Would Be’: How Creating A Shared World Through Collaborative Roleplaying Helps Us Deal With Real-World Challenges, Pablo Muslera

Imaginings: creative practice and inquiry

A creative prose artefact and critical exegesis illustrate how roleplaying games explore community and identity. A prose dramatisation of a cooperative TTRPG (table top roleplaying game) juxtaposes the collaboratively imagined world, and the reality from which it is an escape. Themes of gender identity, isolation, precarious work and fluctuating health are explored within the timeframe of the Covid outbreak in Adelaide mid-2020, with the roleplaying session serving as a respite from insecure work and health challenges, while supporting creative agency and the expression of meaningful selfhood through collaborative play and problem-solving. This reflects a broader phenomenon of the increased popularity …

Cpr: Knowing Through The Making, Dugald Graydon

Imaginings: creative practice and inquiry

The methodologies used in the creation of artistic work and, in the academic setting, the explanation of the processes of artistic inquiry and their findings is necessarily non-prescriptive and potentially requires artists to innovate on methodology, combining existing methods and creating new ones on a case-by-case basis. Creative Practice Research addresses these issues by offering a methodologically diverse range of principles that artists can use to articulate their subjective creative practices in an academic setting, challenging traditional research methods while also legitimising creative work within academia. The following paper provides a brief application of this methodology in the context of …

The Monstrous Other: Exploring Negative Representations Of Queerness In Genre Cinema, Mark Gambino

Imaginings: creative practice and inquiry

The following literature review is an extract from my SAE University College Masters thesis, Disrupting negative representations of queerness in genre cinema, conferred in September 2024. The project explored representations of the queer Other in film horror, through artefact-exegesis, with the creative artefact, horror film Shadows, interrogating the coding of trans / queer characters as the ‘monstrous Other’ in the horror film genre, and how this notion can be subverted and transcended.

Pigments, Bridge Of Disciplines, Candace Gwyther

Imaginings: creative practice and inquiry

What follows is an excerpt from Pigments: The Bridge of Disciplines, a practice-based Masters thesis exploring the intersection of oil painting and ceramics through shared material processes. The literature review grounds the research in theories of Meshwork, Play, Bricolage, and Path making, framing an interdisciplinary approach that challenges traditional boundaries and fosters new modes of creative expression.

Orchestrating Brilliance In The Recording Studio: Mixing Music To Record Music, Adrian Carroll

Imaginings: creative practice and inquiry

This paper is a report on a heuristic inquiry into music recording practice and workflow to arrive at the essence of experience. Through professional reflection on a music recording, we investigated the recording process and student experience; this was used to identify, explore and expose tacit professional practice. The central theme that unfolded revealed benefits in mixing music during a recording session. Other themes of workflow efficiency, and emotional expression, also emerged from the data collection. The research culminated in a creative synthesis in the form of a research question: Can live studio recordings be a viable option for artists, …

Considerations When Exploring One’S Arts-Based Practice As Research, David L. Page

Imaginings: creative practice and inquiry

This article shares insight into some of the knowledge gained on a higher degree research (HDR) study journey, which I wish I had access to prior to my commencement of that journey. I presented this on 8 July 2025 at the SAE University College Week 7 Forum, and trust this insight may be of interest to those SAE faculty who are new to higher education (HE) research, who have an interest in exploring one’s own arts-based practice as part of the Scholarship and Research activities now being encouraged at SAE University College.

The Methodological Approach Of My Emergent Auto-Ethnographical Journey In Arts-Based Practice As Research (Abr): Music & Sound-Making, Meaning-Making, Self-Making, David L. Page

Imaginings: creative practice and inquiry

This article discusses the methodological approach of my professional Doctor of Creative Industries (DCI) Research Project 1 study. The aim of higher degree research (HDR) Project 1 was to investigate my DIY music & sound-making practice and self as a practitioner, in the process of creating and producing a DIY music artefact. Specifically: to investigate why I as the practitioner felt an authentic connection with one form of music & sound-making (acoustic instrument-based), and not a connection with another form of music & sound-making (digital virtual-based).

In Tensile // In Between, Corinna Di Niro

Imaginings: creative practice and inquiry

"In Tensile // In Between" operates as both artistic artefact and theoretical critique, demonstrating how creative practice can embody and extend academic discourse. This creative-critical work examines shifting perceptions of course delivery within creative tertiary education, arguing that project-based learning enables the seamless embedding of socio-cultural discourse and theories within practical making processes.

The poem interrogates how educational environments can cultivate critical thinking through what I term "tensile pedagogy"—an approach that maintains productive charge between opposing forces rather than seeking synthesis or resolution. This concept builds upon King's (2017) work on pedagogy as tension, which argues that "tension and incompleteness …

Bodies That Sparkle And Spill: A Poetics Of The Burlesque Parent, Lola Montgomery

Imaginings: creative practice and inquiry

The embodied experiences of burlesque performers during motherhood are explored in an online discussion, through femme theory, Bakhtin's grotesque body, and Butler's gender performativity. The participants' bodies are explored as sites of contestation, able to perform diverse roles simultaneously. Through performance, Mulvey's masculine gaze is inverted into a poetics of feminine praxis.

Montserrat Developments Impacting Local Coral Reefs, Emma I. Bartholomew

2025 Symposium

Montserrat is a small island in the Caribbean, and over half of the island is in the exclusion zone because of the active volcano, Soufrière Hills. In that half was the old capital, Plymouth, which has since been abandoned, and its old port. The old port was getting less reliable and accessible, so they decided to build a new port in Little Bay, closer to the seat of government in Brades. This study explored how the addition of the new port impacted the corals in that area. We explored several different bays and recorded the diversity and health of the …

Transforming Leadership Behaviors And Thriving Through The Storm In A High Reliability Organization, Rajveer Kaur, Jiji Andrews, Kambree Baxter

Creating Healthy Work Environments (CHWE)

The structural inequities have affected critical care nurses, health care worker’s health and well-being (Durrah et al, 2022; Wells, S., 2024). Prioritizing nurse wellbeing has been formed to improve psychologically safe work environments associated with positively decreasing barriers in patient outcomes within the workforce (Wells, S., 2024). Authentic leaders developed patient advocacy, trusting relationships with their employees to increase the access to proper nursing services to enhance the ability to thrive at work ( Alhalal et al, 2024a; Durrah et al, 2022). Authentic leadership tool was introduced to design interventions and policies specifically for nurse manager’s authentic leadership style to …

Leveraging Meaningful Recognition To Create And Sustain Healthy Work Environments, Cindy Lefton

Creating Healthy Work Environments (CHWE)

Meaningful recognition, a form of feedback describing how one makes a difference in the life of another, also serves to illustrate the elements of a healthy work environment in action. Focusing on meaningful recognition as a catalyst to shape and drive healthy work environments, attendees will be introduced to evidence-based budget neutral practices they can utilize to positively impact team members, workplace culture, and patient experience.

Transforming A Nurse Residency Program: Building Resilience To Enhance Professional Well-Being, Deborah Ambrosio Mawhirter, Maria L. Triolo

Creating Healthy Work Environments (CHWE)

Introduction: A nurse residency program fosters professional growth and aids in the transition into practice. As nurses enter the workforce, they may become overwhelmed and stressed. There is a growing recognition that nurses need assistance in developing skills for resilience. A process of adapting when faced with challenges such as stress and adversity. Educating nurses in a residency program by providing interventions to promote healthy behaviors, self- care and develop a resiliency plan enhances the work environment and allows nurses to flourish. Nurses that build self-care into personal resilience plans bolster individual wellness and promote wellness. Integrating a culture of …

Three-Pronged Mentorship Model, Sherrilyn D. Coffman, Dawn Taylor

Creating Healthy Work Environments (CHWE)

Background: ______ ______ University embraces a caring-based philosophy, which frames both our curriculum and our faculty way-of-being. Our School of Nursing has grown rapidly in recent years, adding more faculty to meet the needs of greater numbers of students. The faculty mentoring program has also expanded and developed into three phases: (1) Onboarding (belonging), (2) Mentorship (competency), and (3) Sponsorship (empowerment).

Purpose: This presentation will describe components and activities of the Three-Pronged Mentorship Model, and summarize evaluation data from our first year, ranging from August 2023 to December 2024.

Influence of Caring Theory: The mentoring program is aligned with Watson’s …

Combining Organizational Assessment And Evidence-Based Strategies To Address Incivility In Nursing, Guillaume Ngonmeudje

Creating Healthy Work Environments (CHWE)

The workplace environment in healthcare is complex and negatively influenced by an increasing pattern of incivility. Recent reports of the increasing prevalence of incivility and related disruptive behaviors within nursing academic and clinical settings are alarming. Incivility threatens the sense of belonging needed to support and nurture the development of nursing students in the profession, and significantly impacts the work performance of front-line healthcare workers, contributing to medical errors and poor patient outcomes (Patel et al., 2022). Nurses and nursing students must be well equipped to effectively address incivility in the workplace and promote the collaboration necessary to optimize patient …