Digital Commons Network^™

From Sequence To Allostery: How Amino Acid Differences Rewire Coupled Conformational Heterogeneity In The Ptp Enzyme Family, Shivani Sharma

Dissertations, Theses, and Capstone Projects

Protein Tyrosine Phosphatases (PTPs) are critical regulators of cellular signaling, and their activity is often modulated through allosteric mechanisms. Allostery is defined as a chemical or conformational change in one site of the protein due to a binding event at another site. Although several studies have investigated aspects of allostery in PTPs, the mechanistic foundations underlying allosteric regulation remain poorly understood. Despite a highly conserved catalytic domain across PTPs, regions with low or no conservation suggest potential "rewiring" of allosteric networks. This raises key questions about the universality versus individuality of allosteric mechanisms across the PTP family.

In this work, …

Moralists Or Moral Hypocrites? Leveraging Moral Psychology And Social Identity Theory To Increase Support For Reparations Amongst White Americans, Andre Oliver

Dissertations, Theses, and Capstone Projects

The economic gains America made from the enslavement of Africans have long been considered its original sin; indeed, most people living today would agree that such an enterprise was morally depraved. Yet, due to moral opposition, many White Americans reject reparative policies (i.e., reparations) that are developed to remedy the damages done to African Americans by slavery and the subsequent continued discrimination. The present research attempts to address two broad hypotheses across four empirical research studies. The first hypothesis tests whether White Americans' rejection of reparative policies related to slavery and Black discrimination is inherently a moral objection to taboo …

Receptions Of Mental Health Emergency Services In New York City, Daniel R. Samost

Dissertations, Theses, and Capstone Projects

Mental health emergency response has become a highly scrutinized topic following the Black Lives Matter movement and several notable incidents of mental health emergency service users being killed by police responders. Qualitative interviews were conducted with mental health emergency service users to better understand the experience of using mental health emergency services, garner critical feedback of the service, and explore recommendations to improve future response. A total of 23 participants conducted interviews and detailed 40 incidents of mental health emergency service utilization. These interviews were then coded and analyzed. There were a few major findings from the data. Just over …

Potential Role Of A Ruthenium-Based Compound Ru-Im In The Treatment Of Triple Negative Breast Cancer, Rachele Rameau

Dissertations, Theses, and Capstone Projects

Triple negative breast cancer (TNBC) is an aggressive and heterogeneous molecular subtype of breast cancer that has limited available treatments. The organometallic cationic ruthenium derivative Ru-IM was found to be highly water soluble, was differentially toxic for breast cancer cells and tumors, and was involved in the pI3K/AKT/mTOR pathway. However, a full understanding of genetic and epigenetic factors that can be part of regulatory mechanisms of Ru-IM is yet to be determined. Epigenetic assays including DNA methylation, histone acetylation and histone deacetylation were performed with the half inhibitory concentration (IC50) values of Ru-IM. Bisulfite sequencing of untreated and treated MDA-MB-231 …

The Evolution And Reproduction Of Andean Miconia (Melastomataceae), Juan Angulo

Dissertations, Theses, and Capstone Projects

Understanding the factors that shape diversification and distribution in tropical plant lineages is central to explaining the origins of Neotropical biodiversity. Assessing evolutionary history with trait evolution and climatic niche dynamics provides key insights into the drivers of diversification and biogeography, while natural history data remains critical for these evolutionary studies. The Tropical Andes, with its exceptional biodiversity and environmental heterogeneity, offers an ideal setting to explore these processes. In this dissertation, I investigate how reproductive systems, climatic niche dynamics, and pollination strategies influence the evolution and biogeography of Miconia III, a large and ecologically diverse clade in the …

Enjoyment In The Classroom: Reciprocal Student-Teacher Dynamics In Israeli Math Education, Yonaton Gutterman

Dissertations, Theses, and Capstone Projects

Enjoyment is increasingly recognised as a keystone emotion in contemporary models of academic motivation and learning (Pekrun, 2006; Ryan & Deci, 2020). Grounded in Control-Value, Expectancy-Value, and Self-Determination theories, the present study tracked reciprocal affective processes in Israeli mathematics classrooms across ten lessons. Seven teachers and their 257 students (112 fourth-graders; 145 eighth-graders) completed parallel post-lesson questionnaires assessing feedback use, enjoyment, and perceived difficulty. Multilevel ordinal mixed-effects models, latent-growth curve models, and Bayesian random-intercept cross-lagged panel models were estimated to disentangle within-person fluctuations from between-person differences (Hamaker et al., 2015). Confirmatory-factor analyses supported scalar invariance of the key scales over …

Using Machine Learning Methods To Evaluate Undergraduates’ Executive Function In The Context Of Game-Based Measurement, Ming Chen

Dissertations, Theses, and Capstone Projects

Traditional performance-based measurements have faced criticism due to their potential to induce test fatigue and their limited ecological validity. In contrast, game-based assessments have demonstrated the capacity to engage participants effectively in tests and enhance ecological validity by replicating real-world scenarios. Nevertheless, conventional statistical approaches may prove insufficient in capturing the intricate, non-linear associations between participants' gaming performance and their cognitive capabilities. Leveraging the potential of machine learning (ML) techniques, which can model complex problems, offers a promising avenue for estimating students' performance in video games. This dissertation aims to explore various ML methods for the validation of three game-based …

Medication Adherence Among Partnered, Sexual Minority Men Living With Hiv: What’S Love, Interdependence And Comorbidities Got To Do With It?, Kendell M. Doyle

Dissertations, Theses, and Capstone Projects

Sexual minority men (SMM) report higher incidence and prevalence rates of HIV infection relative to their heterosexual counterparts. The burden of HIV infection has garnered research attention focused on HIV risk reduction and HIV disease management (such as medication adherence). More recently, attention has been paid to the association of comorbid chronic health conditions and ART adherence among people living with HIV (PLWH) more broadly. Yet, limited attention has been paid to the association of comorbidities among SMM living with HIV specifically, despite the high rates of HIV among this population and various other risk factors that put SMM at …

Reduce, Replace, Reframe: How Civil Society Organizations Build Resilience In The Face Of Financial And Political Pressures, Merrill Sovner

Dissertations, Theses, and Capstone Projects

In order for civil society organizations (CSOs) to perform essential functions to support democracy and prevent democratic erosion, they must operate sustainably, maintaining resources and legitimacy to carry out their missions. CSOs experience financial and political pressures when resources and legitimacy are withdrawn. CSOs facing both pressures may reduce their activities, replace lost funding, or reframe their work to engage new audiences. How CSOs respond in the face of financial and political pressures has implications for their role in hindering democratic erosion. Yet civil society organizations weather these pressures in ways that are not straightforward; the most targeted organizations may …

In A Dark Wood Amid The Storm: Literary Representations Of Midlife In The Social And Political Turbulence Of A Kindred Era, Robert Mccreanor

Dissertations, Theses, and Capstone Projects

The apparent parallels between the social and political crises of the 19-teens’s to 1930’s and those of today is a source of popular fascination and commentary. Some have argued that much of our current anxieties about impending global doom harken back to the widespread doomsaying of exactly a century ago in relation to World War I, the 1918 Spanish Influenza and the rising authoritarianism of the 1930’s. Exploration of the midlife experience amid 21^st century political and social crises has been prolific and can also be seen to echo literary representations of this particular life stage from the seemingly …

Dónde Están: Searching For Desaparecidos Of The Argentine Dirty War, Paula Fleischer

Dissertations, Theses, and Capstone Projects

This project is a data physicalization textile representing the 30,000 'desaparecidos' from the Argentine Dirty War of late 1970s. The large quilt visualizes the official count of 9,000 missing persons in the shape of a headscarf worn by their mothers and grandmothers, while the overall dimensions of the quilt acknowledges 30,000 missing persons. The quilt and accompanying missing persons posters encourage the viewer to interact with the data, however the observed reluctance to engage influenced the direction of this discussion about the hegemonic disinclination to get involved when authority figures 'disappear' fellow residents of our communities.

Stolen Moments: Jazz And The Opportunity To Capture Hip Hop Fans, Fahiym Abdul-Wasi

Dissertations, Theses, and Capstone Projects

This thesis explores the intricate relationship between jazz and hip-hop, examining how these two influential genres intersect culturally and musically. Jazz, with its rich history and expressive improvisation, laid the groundwork for hip-hop, a genre that emerged as a powerful voice for Black Americans and other disenfranchised communities. The thesis highlights the impact of sampling, a fundamental technique in hip-hop that allows artists to repurpose jazz recordings and thereby preserve their legacy while infusing contemporary narratives. By analyzing key albums and the contributions of notable artists, this study underscores the potential for reintroducing jazz to new audiences through hip-hop. As …

Systematics, Biogeography, And Comparative Morphology Of Emerald And Tigertail Dragonflies (Anisoptera: Synthemistidae & Corduliidae), Aaron M. Goodman

Dissertations, Theses, and Capstone Projects

Dragonflies and damselflies (Odonata Fabricius, 1793) are among the most widely recognized and charismatic insect groups, whose significance have permeated throughout artwork, culture, and religion. They are highly mobile predators, currently consisting of ~ 6,500 species, and possessing some of the complex visual color systems, visual acuity, and flight patterns on Earth. Odonata are the among the earliest flying insects, with proto-odonates (Griffinflies) dating back to the Carboniferous (~360mya), with crown-odonata fossils stretching back to the Triassic (~250mya). Overall, dragonflies and damselflies are considered models of ecological and evolutionary research due to their long evolutionary history, range of habitats, and …

“Justice, Justice Pursue”: Coworker Reactions To Religious Workplace Accommodations, Joshua A. Nagel

Dissertations, Theses, and Capstone Projects

This study examines coworker reactions to religious accommodations in the workplace, a growing necessity as religious diversity increases, and recent legislation strengthens protections for religious observances. Religious accommodations can provoke perceptions of differential treatment, impacting coworker morale, cooperation, and organizational cohesion. While extensive research exists on disability accommodations, religious accommodations differ fundamentally as they often relate to moral beliefs and are viewed variably in terms of necessity and controllability. Drawing on organizational justice theories, this dissertation applies and modifies Colella’s (2001) and Colella et al.’s (2004) models for coworker perceptions of distributive and procedural fairness of disability accommodations to the …

Transitional Justice And Counter-Productivity: A Case Study Of Serbia And Croatia, Michael F. Curry

Dissertations, Theses, and Capstone Projects

In the post-Cold War era, transitional justice emerged as a method to reconcile societies that had suffered large-scale human rights abuses through autocratic oppression and/or intra-state conflicts. During this time, the concept of what transitional justice meant and what problems it could resolve expanded exponentially. However, the empirical results of such initiatives have been mixed. Many states subject to transitional justice initiatives have failed to liberalize or develop domestic governance capacities. Why do transitional justice initiatives fail even under the most favorable conditions?

The most common answer to this question is that these initiatives are often ineffective, hindered by a …

Alerted And Anxious? The Effects Of Mobile Crime Alerts On Perceptions Of Personal And Public Safety, Amanda C. Benjamin

Dissertations, Theses, and Capstone Projects

Mobile crime alert platforms promise to enhance personal and public safety by delivering frequent notifications about nearby dangers—claims that, until now, have not been experimentally tested. For-profit applications like Citizen deliver real-time, geo-targeted push notifications about nearby crime incidents to over 9 million users, often operating outside the bounds of institutional oversight. Although marketed as tools to enhance awareness and protection, these platforms may simultaneously empower users through information while also potentially amplifying anxiety, heightening threat perceptions, and eroding trust in community. Despite their increasing prominence and integration into public safety communications, the psychological and behavioral impacts of mobile crime …

Nonlinear Diffusion, Hydrodynamic Cascades And Jamming In Kinetically Constrained Systems: Insights From Lattice Gas Models, Abhishek Raj

Dissertations, Theses, and Capstone Projects

This dissertation investigates non-linear diffusion processes and emergent dynamical phenomena in kinetically constrained lattice gases. Two central models are considered: a one-dimensional lattice gas exhibiting a diffusion cascade triggered by hydrodynamic nonlinearities and a triangular ladder exclusion model that undergoes a jamming transition. The former demonstrates stretched exponential decay consistent with non-perturbative long-time tails, while the latter illustrates how classical-quantum mappings yield insight into glassy dynamics and mobility constraints. Through a combination of numerical simulations, analytical perturbation theory, and mean-field approximations, the work uncovers mechanisms underlying anomalous transport, jamming transitions, and the breakdown of perturbative hydrodynamics.

Disability Theatre Communities: Engaging Artists And Audiences In Contemporary International Performance, Joseph Paul Hill

Dissertations, Theses, and Capstone Projects

“Disability Theatre Communities” examines how communities are constructed in, through, and around contemporary international disability theatre performances. It explores ideas of community formation and intersection across three case studies to elucidate the various ways in which disability theatre artists, productions, companies, and organizations attract, engage, and educate variable artist and audience communities. The project analyzes Rome, Italy’s Teatro Patologico and its Integrated Theatre of Emotion, a theatrical training program for neurodivergent performers; Wales-based writer, theatre-maker, and dramaturg Kaite O’Reilly, whose international collaborations center d/Deaf and disabled performers and foreground audience accessibility; and the biennial BIT (Blind in Theatre) International Festival …

Towards Automated Evolution Of Imperative Deep Learning Programs, Tatiana Castro-Vélez

Dissertations, Theses, and Capstone Projects

Software engineering (SE) is increasingly intersecting with data-centric domains such as machine learning (ML) and deep learning (DL). Similar to bugs in traditional software systems, defects can emerge in ML and DL systems. ML, including DL, systems are now widespread and rely on dynamic models defined by input data. Developers face the challenge of building dependable systems while addressing the demand for scalable software.

Efficiency is essential to support responsiveness with respect to ever-growing datasets. Traditional DL frameworks achieve scalability through deferred execution, enabling symbolic, graph-based deep neural network (DNN) computation. While efficient, this approach is error-prone, cumbersome, and difficult …

Multi-Nuclear Magnetic Resonance (Nmr) Characterization Of Novel Materials, Tawhid Pranto

Dissertations, Theses, and Capstone Projects

The increasing reliance on batteries in commercial products, coupled with the environmental challenges posed by climate change and the limitations of fossil fuel consumption, has created strong financial and environmental incentives to explore innovative energy storage solutions. Renewable energy sources are being actively developed, but their intermittent nature necessitates efficient storage technologies, driving significant research into improving the performance of batteries, fuel cells, and capacitors.

This thesis focuses on the application of advanced Nuclear Magnetic Resonance (NMR) spectroscopy to study and understand novel materials for energy storage applications, with an emphasis on electrolytes for rechargeable lithium-ion batteries and all-solid-state batteries. …

Leveraging Stellar Chemistry For A Global View Into The Atmospheres Of Brown Dwarfs And Giant Exoplanets, Emily Calamari

Dissertations, Theses, and Capstone Projects

In the era of the James Webb Space Telescope (JWST), it is now possible to examine substellar mass atmospheres in unparalleled detail and precision. However, unraveling the complicated thermodynamics and chemistry in these atmospheres remains a challenge. Atmospheric retrievals are a leading data-driven technique capable of recovering an object’s fundamental parameters such as mass, radius, effective temperature, gravity, cloud structure and composition and chemical abundances. However, in directly imaged or isolated worlds, constraining and/or interpreting these fundamental parameters can be difficult, particularly as retrieval models try to parameterize the overall impact of clouds.

For my dissertation, I turned to main …

Performance Practice As Compositional Style: Wet Ink’S Collaborative Work, Carrie Frey

Dissertations, Theses, and Capstone Projects

In its twenty-five years in New York City’s new music scene, Wet Ink Ensemble has established a distinctive approach in which members blend the roles of performer, composer, and improviser. This dissertation investigates how the ensemble’s beginnings at the nexus of the experimental rock and avant-garde music scenes prepared it for a turn towards collaborative composition and improvisation. After defining essential elements of the ensemble’s performance practice, I analyze Eric Wubbels’ Auditory Scene Analysis (I) and Sam Pluta’s Lines on Black—compositions that exemplify opposing poles of notational specificity. I then trace the defined elements through two “Performance Practice” works, …

Repurposing Atractylenolide Iii, A Natural Anti-Inflammatory Compound, For Alzheimer’S Disease, Angela M. Steele

Dissertations, Theses, and Capstone Projects

Alzheimer’s disease (AD) is a debilitating neurological condition ranked as the fifth leading cause of death in adults over the age of 65. Despite the severity, 98% of drugs have failed as treatments for AD. Current novel drug development approaches have been unable to produce a disease-modifying treatment as they often have a one-target approach, not accounting for the complex nature of the disease. One of the hallmarks of the disease, inflammation, may provide a better target for treatment because it interacts with multiple facets of the disease. Drug repurposing to identify compounds that mitigate inflammation in AD could provide …

Form And Structure In African Music: Four Case Studies In San, Por Por, Ewe, And Aka Music, Bai Xue

Dissertations, Theses, and Capstone Projects

This dissertation examines the organizational principles in African music through the analysis of four distinct musical traditions: the San music of Southern Africa, Por Por honk-horn music of urban Accra (Ghana), the Northern and Southern Ewe music of Ghana, and the Aka music of the Central African Republic. While the study of African music has often emphasized its sociocultural and rhythmic aspects, structural principles have remained a relatively underexplored subject. This study argues that African music is highly structural yet should not be analyzed as fixed blueprints. Instead, it introduces a “block-based method” for analyzing oral music, the first step …

Double Exposure: Motherhood And Filmmaking, Eddy Berzak

Dissertations, Theses, and Capstone Projects

This capstone project explores the intersection of motherhood and filmmaking through a reflexive documentary that examines how women directors have historically navigated the tensions between creative careers and raising children. Drawing on feminist film theory and autoethnographic methods, the fourteen-minute video essay analyzes three pioneering autobiographical documentaries from the 1970s—Joyce at 34 (1973), Nana, Mom and Me (1974), and Women Are Naturally Creative: Agnès Varda (1977)—alongside original footage documenting my own experience as a mother with deferred filmmaking aspirations. The project employs reflexive documentary techniques to weave together film analysis and personal narrative, investigating the central question: why didn't I …

Mechanistic Insights Into The Neuroprotective Effects Of The Antidepressant Agomelatine In Alzheimer's Disease, Grace Terry

Dissertations, Theses, and Capstone Projects

Alzheimer’s Disease (AD) is a complex neurodegenerative disease that has limited treatment options and no cure. AD is characterized by robust pathology including extracellular amyloid beta plaques, intracellular neurofibrillary tangles, neuronal and synaptic loss, neuroinflammation, and brain atrophy. AD presents with cognitive decline and memory loss but only years after neuropathology has started to accumulate. This robust pathology has made AD difficult to treat and highlights the need for therapeutics that modulate multiple pathways. Agomelatine (AGO) was selected by a high-throughput machine learning drug repurposing algorithm by our collaborator Dr. Lie Xie (Hunter College Dept. of Comp. Sci.) as having …

Investigating The Role Of Early Growth Response 1 (Egr1) Gene In Riluzole-Induced Apoptosis In Osteosarcoma, Syeda Maryam Azeem

Dissertations, Theses, and Capstone Projects

Osteosarcoma is a rare but aggressive bone malignancy most commonly affecting adolescents and young adults (AYA). With 5-year survival rate stagnating over the last four decades despite the advancements in multi-modal therapy, drug repurposing offers a rapid path to new osteosarcoma treatments. Recent studies suggest that Riluzole, a drug approved for amyotrophic lateral sclerosis (ALS), may be repurposed for osteosarcoma treatment due to its ability to slow tumor progression and induce apoptosis. Previously, we have shown that Riluzole increases reactive oxygen species (ROS), activating c-Abl, which phosphorylates YAP in the nucleus. YAP then forms a complex with p73 to enhance …

Bmp Signaling Co-Regulation Of Immune Response And Lipid Metabolism, Katerina K. Yamamoto

Dissertations, Theses, and Capstone Projects

The Bone Morphogenetic Proteins (BMPs) are secreted peptide ligands of the Transforming Growth Factor beta (TGF-β) family, initially identified for their roles in development and differentiation across animal species. They are now increasingly recognized for their roles in physiology and infectious disease. In the nematode Caenorhabditis elegans, the BMP ligand DBL-1 controls fat metabolism and immune response, in addition to its roles in body size regulation and development. DBL-1 regulates classical aspects of innate immunity, including the induction of anti-microbial peptides. We theorized that BMP-dependent regulation of fat metabolism could also promote resilience against microbial pathogens. We found that …

From Stories To Strategy: Oral Histories As Qualitative Evidence For Neighborhood Planning, Randip K. Parhar

Dissertations, Theses, and Capstone Projects

Developments in neighborhood planning have sought more grounded and community- engaged approaches to space and service design. This capstone project examines how oral history recordings can serve as a data source for neighborhood planning. It asks “How can computational methods of analysis be applied to oral history recordings to provide a source of information for neighborhood planning?” using Jamaica, Queens, as a testbed. Using R as a computational tool, the project applies foundational text mining techniques, such as term frequency analysis, n-gram analysis, and topic modeling, to explore patterns and themes within the recorded narratives. These methods can provide a …

Socioeconomic Stasis And Racial Immobility In The United States: How Does American Political Polarization Contribute To African American Poverty?, Carmel Agnant

Dissertations, Theses, and Capstone Projects

African Americans in the United States presently exist in a poverty-stasis, a perpetual social and economic underclass positioning despite a constantly evolving American economy, society, and bodies of legislations due to political polarization. This follows a lengthy history of racial immobility (preventing a racial group from economic mobility) and stagnation since America’s era of sectional polarization over slavery. African Americans lack access to build wealth and have always struggled with societal exclusion. Legislation created and enacted that would support them politically, legally, socially, and/or economically are consistently met with legislative gridlock or countervailing measures to reverse and nullify advancements in …