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Homoeopathic Pathogenetic Trial Of Blatta Orientalis: A Multicentric, Double Blind, Randomised, Placebo-Controlled Trial, Pritha Mehra, A. K. Vichitra, Amulya R. Sahoo, B S J Rajakumar, Bhopal S. Arya, Karuna Karuna, Ritika Singhal, Anil Khurana, R. K. Manchanda Sep 2025

Homoeopathic Pathogenetic Trial Of Blatta Orientalis: A Multicentric, Double Blind, Randomised, Placebo-Controlled Trial, Pritha Mehra, A. K. Vichitra, Amulya R. Sahoo, B S J Rajakumar, Bhopal S. Arya, Karuna Karuna, Ritika Singhal, Anil Khurana, R. K. Manchanda

Indian Journal of Research in Homoeopathy

Background: The therapeutic effect of Blatta orientalis in asthma was found accidentally, but apart from the respiratory symptoms, not much is known about this as a drug through proving in Homoeopathy. Thus, homoeopathic drug proving was carried out, which is the first step in finding pathogenetic effect of the drug substance, for suggestive use in a clinical setting. Objective: To elicit the pathogenetic response of Blatta orientalis on healthy human provers. Methods: A multicentre, randomised, double blind, placebo-controlled trial was conducted at three centres under Central Council for Research in Homoeopathy. The trial was conducted on 47 apparently healthy provers …


Investigation Of The Physicochemical Behaviour Of Acidum Citricum Homoeopathic Dilutions At Temperatures From 293.15 K To 318.15 K By Using Volumetric, Acoustic And Viscometric Methods, Anil Kumar Nain, Neha Chaudhary, Raj Kumar Manchanda, Debadatta Nayak Sep 2025

Investigation Of The Physicochemical Behaviour Of Acidum Citricum Homoeopathic Dilutions At Temperatures From 293.15 K To 318.15 K By Using Volumetric, Acoustic And Viscometric Methods, Anil Kumar Nain, Neha Chaudhary, Raj Kumar Manchanda, Debadatta Nayak

Indian Journal of Research in Homoeopathy

Background: The physicochemical properties of homoeopathic medicines have been gaining importance in elucidating the physicochemical behaviour (interactions) and, hence in establishing the presence of medicine at ultra-high dilutions. Objective: The present study is aimed to reconnoiter the existence of drug in ultra-diluted medicines and evidence regarding the physicochemical behaviour and prevailing interactions in the dilutions of Acidum citricum. Materials and Methods: The densities (ρ), ultrasonic speeds (u) and viscosities (η) of pure ethanol control (91% ethanol in water) and 33 dilutions of Acidum citricum of potencies across 1C to 200C at temperatures from …


Evaluation Of Oral Administration Of Calendula Officinalis Among The Centesimal Potencies In Acute Wound Healing In Male Wistar Rats, A Vincer George, Ramadas Naik, Punchappady Devasya Rekha, Melita Alva, Vivek Ramakrishnan, Suprith Surya, Ranajit Das Sep 2025

Evaluation Of Oral Administration Of Calendula Officinalis Among The Centesimal Potencies In Acute Wound Healing In Male Wistar Rats, A Vincer George, Ramadas Naik, Punchappady Devasya Rekha, Melita Alva, Vivek Ramakrishnan, Suprith Surya, Ranajit Das

Indian Journal of Research in Homoeopathy

Background: Calendula officinalis (Calendula) is used in Homoeopathy to treat various wounds. The presence of bioactive compounds results in pharmacological properties like wound healing, antioxidants, and anti-inflammatory properties. Hence, clinicians use different centesimal potencies (6C, 30C, 200C) to heal wounds. Objective: To compare the wound-healing potential of Calendula dilutions (6C, 30C, 200C) through oral administration in a pre-clinical acute wound model. Materials and Methods: The study involved administering Calendula centesimal potencies (6C, 30C, 200C) orally. Male wistar rats aged eight to ten weeks were involved in the experiment. Every animal had full-thickness excisional wound created on its back …


A Case Report On Multiple Renal Calculi And Bilateral Ovarian Cysts Treated With Homoeopathic Medicine Ignatia Amara, Pragya Sharma Sep 2025

A Case Report On Multiple Renal Calculi And Bilateral Ovarian Cysts Treated With Homoeopathic Medicine Ignatia Amara, Pragya Sharma

Indian Journal of Research in Homoeopathy

Introduction: Renal calculi are the most frequent urological illness. It can be caused by genetic, nutritional, or environmental factors. Ovarian cysts are fluid-filled structures which can be simple or complex. It can affect females of any age, whether during puberty or menopause. These disorders remain a medical challenge due to their complex aetiology and high incidence. Sometimes the symptoms grow so severe for the patient that treatment and time lost from work involve substantial costs, compromising their social, physical, psychological, and financial well-being. Case summary: This is a case report of a 38-year-old female having sharp cutting pain in lumbar …


Indian Standard Of Plastic Containers And Closures For Dispensing Homoeopathic Pharmaceutical Preparations, Homoeopathy Sectional Committee, Ayush Department, Bureau Of Indian Standards, New Delhi, India Sep 2025

Indian Standard Of Plastic Containers And Closures For Dispensing Homoeopathic Pharmaceutical Preparations, Homoeopathy Sectional Committee, Ayush Department, Bureau Of Indian Standards, New Delhi, India

Indian Journal of Research in Homoeopathy

Homoeopathic medicines require safe packaging to maintain their quality and effectiveness. Proper packaging prevents contamination, preserves potency, and ensures patient safety. Hence, Bureau of Indian Standards (BIS) had received the proposal from the Ministry of Ayush for the development of BIS standards for packaging material used for homoeopathic medicinal products (HMP). One such packaging is plastic containers. Accordingly, IS 19084: 2024 was developed and notified, which specifies requirements for plastic containers and closures used for packaging, storage, and dispensing of homoeopathic pharmaceutical preparations in solid and liquid dosage forms. This paper reports the details of the standard and the methodology …


Principles And Practice Of Homoeopathy Part Ii: Advancing Frontiers–A Book Review, Surbhi Jain Sep 2025

Principles And Practice Of Homoeopathy Part Ii: Advancing Frontiers–A Book Review, Surbhi Jain

Indian Journal of Research in Homoeopathy

Book Review on ‘Principles and Practice of Homoeopathy Part II: Advancing Frontiers’


The Parthenon, September 24, 2025, Baylee Parsons, Kaitlyn Fleming, Ashton Pack, Nate Harrah, Caden Adkins, Scott Price, Lilli Ross, Wade Sullivan Sep 2025

The Parthenon, September 24, 2025, Baylee Parsons, Kaitlyn Fleming, Ashton Pack, Nate Harrah, Caden Adkins, Scott Price, Lilli Ross, Wade Sullivan

The Parthenon

No abstract provided.


Midweek Memo, Georgia Southern University Sep 2025

Midweek Memo, Georgia Southern University

Midweek Memo

  • Applaud
  • Remember
  • Share
  • Experience
  • Around the Nest


Effective Strategies For The Implementation Of Environmental Social And Governance Initiatives To Improve Brand Value, Charity Ndisengei Sep 2025

Effective Strategies For The Implementation Of Environmental Social And Governance Initiatives To Improve Brand Value, Charity Ndisengei

Walden Dissertations and Doctoral Studies

Some business leaders lack effective strategies to develop and implement their organization’s environmental, social, and governance (ESG) initiatives to improve the value of the organization’s brand. Business leaders, in particular, are concerned with balancing the improvement of brand value while addressing stakeholder expectations and navigating regulatory complexities. Grounded in institutional and legitimacy theories, the purpose of this qualitative pragmatic inquiry was to explore effective strategies for the implementation of ESG initiatives to improve brand value. Participants included five senior leaders from the energy, nonprofit, technology, and consulting sectors who had implemented ESG initiatives. Data were collected through semistructured interviews and …


Cyberloafing And The Effects On Information Technology Infrastructure, Robert Ceneskie Sep 2025

Cyberloafing And The Effects On Information Technology Infrastructure, Robert Ceneskie

Walden Dissertations and Doctoral Studies

Cyberloafing, or the use of business resources for nonwork-related internet activity, can negatively affect technology infrastructure and organizational productivity. In K–12 public school districts, IT administrators and school leaders are directly affected, as network degradation and ransomware attacks can disrupt instruction, compromise sensitive data, and reduce access to critical resources. This quantitative correlational, ex post facto study, grounded in activity theory and the theory of human-technology interaction, was to determine whether there was a statistically significant relationship between employee cyberloafing, network degradation, and ransomware security attacks in the education sector. Data were collected through public records requests for bandwidth usage, …


Covid-19 Infection Prevention And Control Guidelines Of Philippine Physical Therapy Association (Ppta) And Rehabilitation Department Of Select Hospitals In The Philippines: Impact On Infection Trend, Ghiester Marc T. Estrellado, Venize Edanne F. Montecillo, Cristina Faye C. Panopio, Alexandra Marie V. Amistoso, Raymond M. Tosoc Sep 2025

Covid-19 Infection Prevention And Control Guidelines Of Philippine Physical Therapy Association (Ppta) And Rehabilitation Department Of Select Hospitals In The Philippines: Impact On Infection Trend, Ghiester Marc T. Estrellado, Venize Edanne F. Montecillo, Cristina Faye C. Panopio, Alexandra Marie V. Amistoso, Raymond M. Tosoc

Philippine Journal of Physical Therapy

Introduction: There is a paucity of evidence supporting the need for setting up hospital COVID-19 infection prevention and control (IPC) guidelines for Physical Therapists (PTs) that meet global standards. This study aimed to determine the consistency of IPC guidelines among different rehabilitation departments of hospitals within Region IV-A and the Philippine Physical Therapy Association’s (PPTA) recommendations with the World Health Organization’s (WHO) IPC guidance document. It also compared the hospitals’ consistency scores with the trend of infected PTs per month.

Methods: In this descriptive cross-sectional survey, an online checklist was developed and validated to examine the consistency of the IPC …


Curatorial Statement For Oral Histories Collection, Chandler D. Smith Sep 2025

Curatorial Statement For Oral Histories Collection, Chandler D. Smith

LSUHSC Hurricane Katrina Archive: Oral Histories

This curatorial statement includes details about the conception and execution of the LSUHSC Hurricane Katrina Archive Oral Histories collection project by library faculty and staff. Updated version posted on April 29, 2026.


An Updated Checklist Of The Mammals Of Türkiye, Mustafa Sözen, Faruk Çolak Sep 2025

An Updated Checklist Of The Mammals Of Türkiye, Mustafa Sözen, Faruk Çolak

Turkish Journal of Zoology

Between 1982 and 2025, the number of extant wild mammal species worldwide rose from 4170 to 6706. The Turkish mammal fauna also showed a similar trend, with the number of mammal species listed for Türkiye rising from 89 to 173 in just 33 years, from 1989 to 2021. A shift in species numbers like this calls for regular updates to Türkiye’s mammal species lists as well as the preparation of new checklists. Apart from changes in the number of species, numerous taxonomic changes and rearrangements also lead to changes in mammal lists. We arranged an updated mammal checklist by reviewing …


अध्ययन, अध्यापन, अनुसंधान: Celebrating 270 Years Of Homoeopathy And Scientific Integration, Jyoti Sachdeva, Pankhuri Misra, Sonu Kumar, Divya Taneja, Renu Mittal, Subhash Kaushik Sep 2025

अध्ययन, अध्यापन, अनुसंधान: Celebrating 270 Years Of Homoeopathy And Scientific Integration, Jyoti Sachdeva, Pankhuri Misra, Sonu Kumar, Divya Taneja, Renu Mittal, Subhash Kaushik

Indian Journal of Research in Homoeopathy

The World Homoeopathy Day (WHD) 2025 convention, held on 10th–11th April 2025 at Mahatma Mandir, Gandhinagar, commemorated the 270th birth anniversary of Dr. Samuel Hahnemann, the founder of Homoeopathy. Organized by the Central Council for Research in Homoeopathy (CCRH), the National Commission for Homoeopathy (NCH), and the National Institute of Homoeopathy (NIH), under the Ministry of Ayush, the event witnessed an unprecedented gathering of 8,651 delegates, making it the largest-ever congregation of homoeopathic professionals, students, and researchers. Centered on the theme

अध्ययन, अध्यापन, अनुसंधान

(Education, Teaching, and Research), the event emphasised the integration of scientific research, clinical practice, and education …


Research Highlights, Garima Jindal, Anjali Shah Sep 2025

Research Highlights, Garima Jindal, Anjali Shah

Indian Journal of Research in Homoeopathy

Research highlights


Evaluating The Role Of Homoeopathy In Rural And Low-Resource Settings, Parth Aphale, Shashank Dokania, Himanshu Shekhar Sep 2025

Evaluating The Role Of Homoeopathy In Rural And Low-Resource Settings, Parth Aphale, Shashank Dokania, Himanshu Shekhar

Indian Journal of Research in Homoeopathy

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Effectiveness Of Individualised Homoeopathy In Hypertrophied Adenoids In Pediatric Population: A Single-Arm, Prospective Pilot Study, Shereena Ussi, Vinitha Edavattath Ramanan Sep 2025

Effectiveness Of Individualised Homoeopathy In Hypertrophied Adenoids In Pediatric Population: A Single-Arm, Prospective Pilot Study, Shereena Ussi, Vinitha Edavattath Ramanan

Indian Journal of Research in Homoeopathy

Background: Adenoid hypertrophy is the most common cause of upper airway obstruction in children. Objective: The primary objective was to determine the reduction in hypertrophied adenoids in children after homoeopathic treatment, using nasal endoscopic assessment. The secondary objectives were to identify the changes in symptoms of hypertrophied adenoids in children after administration of homoeopathic medicines using “Four-point clinical rating scale for adenoidal symptoms (FPCR)” and to find out the utility of homoeopathic medicines in reducing the frequency of upper respiratory tract infections (URTI) in children with hypertrophied adenoids. Materials and methods: Thirty children between 3–14 years of age, with signs …


Lm Potency Of Calcarea Carbonica For Individualised Homoeopathic Treatment Of Polycystic Ovarian Syndrome: A Case Report, Rayba Khatoon, Sumanta Kamila, Sanjay Sarkar, Javed Aquatar Bappa Sep 2025

Lm Potency Of Calcarea Carbonica For Individualised Homoeopathic Treatment Of Polycystic Ovarian Syndrome: A Case Report, Rayba Khatoon, Sumanta Kamila, Sanjay Sarkar, Javed Aquatar Bappa

Indian Journal of Research in Homoeopathy

Introduction: Polycystic ovarian syndrome (PCOS) stands as a prevalent and diverse endocrine disorder affecting women in their reproductive years. It manifests through various clinical symptoms such as oligo-anovulation, polycystic ovaries, and symptoms due to elevated serum androgen levels. Amidst the frequent side effects and limited long-term efficacy of conventional treatments, there is a growing interest in complementary therapies that can alleviate PCOS symptoms without adverse impacts. Homoeopathy, known for its individualised approach and success in treating various conditions, including PCOS, emerges as a hopeful solution. This case report aims to showcase the favourable results attained through individualised homoeopathic treatment not …


Dental Microwear And Diets Of Late Miocene Primates From Rudabánya, Hungary, Peter S. Ungar, Anna K. Wilcox, David R. Begun Sep 2025

Dental Microwear And Diets Of Late Miocene Primates From Rudabánya, Hungary, Peter S. Ungar, Anna K. Wilcox, David R. Begun

School of Dentistry Faculty Publications

Objectives: This study focuses on a dental microwear texture analysis of European pliopithecids and dryopithecins from the Miocene primate site of Rudabánya, Hungary. The goal is to determine whether these taxa, found in part together in the same deposits, differed in their food preferences, or at least consumed, on a daily basis, in a manner that might have facilitated sympatry. Materials and Methods: Here we report on a molar surface texture analysis of all available fossil primates from Rudabánya that preserve antemortem microwear. This includes both Anapithecus hernyaki (n = 14) and Rudapithecus hungaricus (n = 5, including one from …


Refractory Cutaneous Symptoms In Systemic Mastocytosis, Laura Gleason, Safiyyah Bhatti, Molly Wallace, Jason B. Lee, Onder Alpdogan, Neda Nikbakht Sep 2025

Refractory Cutaneous Symptoms In Systemic Mastocytosis, Laura Gleason, Safiyyah Bhatti, Molly Wallace, Jason B. Lee, Onder Alpdogan, Neda Nikbakht

Department of Dermatology and Cutaneous Biology Faculty Papers

No abstract provided.


Middle School Teachers’ Perceptions About Lgbtq+ Inclusivity In The Classroom, Tanya Nordhaus Sep 2025

Middle School Teachers’ Perceptions About Lgbtq+ Inclusivity In The Classroom, Tanya Nordhaus

Walden Dissertations and Doctoral Studies

The problem addressed through this study is that middle school teachers struggle to incorporate LGBTQ+ issues into their classrooms. As the middle school years are pivotal, teachers may need support to be inclusive of their LGBTQ+ students. The purpose of this basic qualitative study was to investigate how middle school teachers incorporate LGBTQ+ issues in the classroom, as well as these teachers’ perceptions of their successes and challenges in doing so. The conceptual framework that grounded this study was queer pedagogy, which questions the normalization of heterosexuality and cisgenderism through pedagogical praxis. For this basic qualitative design, semistructured interviews were …


The Impact Of A Trauma-Informed Care Education Program On Nurses’ Knowledge And Confidence In Managing Sexual Trauma In A Psychiatric Clinic, Fatiatu Jobi Sep 2025

The Impact Of A Trauma-Informed Care Education Program On Nurses’ Knowledge And Confidence In Managing Sexual Trauma In A Psychiatric Clinic, Fatiatu Jobi

Walden Dissertations and Doctoral Studies

Summary This staff education project evaluates whether a staff education program on trauma-informed care (TIC) approaches would improve the knowledge, confidence, and skills of nurses working at a local mental health clinic in managing symptoms of sexual trauma-affected patients. With notable increased incidence of sexual trauma and inadequate protocols to address it there is need for TIC. Sexual trauma, if inadequately addressed, leads to profound and long-lasting psychological effects. The goal of this project was to enhance nurses’ understanding and capabilities related to TIC, using a pretest and posttest interventional design utilizing questionnaire that consisted of three sections: knowledge, perceived …


The Microenvironment Of Ocular Surface In Keratoconus: A Systematic Review, Sana Niazi, Farideh Doroodgar, Stephen Pflugfelder, Kia Bayat, Seyed-Farzad Mohammadi, Maedeh Mazloomi, Jorge L Alió Del Barrio, Majid Moshirfar, Jorge L Alió Sep 2025

The Microenvironment Of Ocular Surface In Keratoconus: A Systematic Review, Sana Niazi, Farideh Doroodgar, Stephen Pflugfelder, Kia Bayat, Seyed-Farzad Mohammadi, Maedeh Mazloomi, Jorge L Alió Del Barrio, Majid Moshirfar, Jorge L Alió

Faculty, Staff and Students Publications

Purpose: Keratoconus is a progressive corneal ectatic disorder characterized by thinning and irregularity of the cornea, significantly impairing visual acuity. Recent studies have explored how non-ectatic conditions, such as dry eye and tear film instability and alteration of the ocular surface microenvironment, contribute to the development and progression of keratoconus. This comprehensive review aims to investigate the complex relationship between keratoconus and ocular surface diseases by examining the microenvironmental changes that occur on the ocular surface throughout the course of keratoconus, as well as the related clinical implications.

Methods: In this PROSPERO-registered study (ID: CRD42025643808), PubMed, Scopus, Cochrane, Embase, Web …


Pediatric Heart Failure: A Practical Guide For Primary Care Providers Supporting Families Across The Care Continuum, Shahnawaz Amdani, Kriti Puri, Julie Glickstein, Joseph A Spinner, Jonathan N Johnson, Ashraf S Harahsheh, Majd Makhoul, Susan Denfield Sep 2025

Pediatric Heart Failure: A Practical Guide For Primary Care Providers Supporting Families Across The Care Continuum, Shahnawaz Amdani, Kriti Puri, Julie Glickstein, Joseph A Spinner, Jonathan N Johnson, Ashraf S Harahsheh, Majd Makhoul, Susan Denfield

Faculty, Staff and Students Publications

Background/Objectives: Pediatric heart failure (HF) is a complex clinical syndrome with diverse etiologies and presentations. Primary care providers (PCPs) are critical in early recognition, family education, and coordination of ongoing care in collaboration with pediatric cardiologists. This review provides a comprehensive guide for PCPs to understand the causes, symptoms, treatments, and longitudinal considerations for children with HF.

Methods: We conducted a narrative review synthesizing published evidence and expert consensus guidelines, focusing on the clinical presentation, treatment options, and longitudinal care strategies in children with HF.

Results: HF in children most commonly results from congenital heart disease and …


Biologic Management In Severe Asthma For Adults: An American College Of Chest Physicians Clinical Practice Guideline, Amber J Oberle, Farrukh Abbas, Muhammad Adrish, Ioana Agache, Megan Conroy, Angel Coz, Frederic F Little, Manoj J Mammen, Mahesh Padukudru Anand, Raju Reddy, Neha Solanki, Fernando Holguin Sep 2025

Biologic Management In Severe Asthma For Adults: An American College Of Chest Physicians Clinical Practice Guideline, Amber J Oberle, Farrukh Abbas, Muhammad Adrish, Ioana Agache, Megan Conroy, Angel Coz, Frederic F Little, Manoj J Mammen, Mahesh Padukudru Anand, Raju Reddy, Neha Solanki, Fernando Holguin

Faculty, Staff and Students Publications

Background: Severe asthma affects 5% to 10% of asthma patients but constitutes close to one-half of the medical costs related to asthma due to higher morbidity and health care utilization. Biologic agents have become a standard of care in those unresponsive to standard treatments yet the choice of biologic agent is complex due to the varying mechanisms of action, efficacies, and lack of head-to-head comparisons. Therefore, clinicians need further clinical guidance to optimize their use.

Study design and methods: Panelists developed key clinical questions utilizing the PICO (population, intervention, comparator, and outcome) format to address choice of a biologic agent …


Two Unh Space Weather Instruments Blast Off Toward The Sun, Rebecca Irelan Sep 2025

Two Unh Space Weather Instruments Blast Off Toward The Sun, Rebecca Irelan

UNH Today Archive

No abstract provided.


Lung Nr3c1+ And Cxcr6high T Cells Distinguish Immunopathogenesis Of Human Emphysema, Yun Zhang, Maor Sauler, David B Corry, Scott A Ochsner, Sarah Perusich, Li-Zhen Song, Joshua Malo, Raul San Jose Estepar, Francesca Polverino, Farrah Kheradmand Sep 2025

Lung Nr3c1+ And Cxcr6high T Cells Distinguish Immunopathogenesis Of Human Emphysema, Yun Zhang, Maor Sauler, David B Corry, Scott A Ochsner, Sarah Perusich, Li-Zhen Song, Joshua Malo, Raul San Jose Estepar, Francesca Polverino, Farrah Kheradmand

Faculty, Staff and Students Publications

There is a significant knowledge gap in how T cells promote emphysema in smokers with chronic obstructive pulmonary disease (COPD). Single-cell RNA sequencing (scRNA seq) analysis of human samples and relevant clinical data can provide new mechanistic insights into disease pathogenesis. We generated a human lung scRNA seq dataset with extensive disease characteristic annotation and analyzed a second independent scRNA seq dataset to examine the pathophysiological role of T cells in emphysema. Comparisons of pulmonary immune landscapes in emphysematous (E)-COPD, non-emphysematous (NE)-COPD, and control showed positive enrichment of T cells in E-COPD. Pathway analyses identified upregulated inflammatory states in CD4 …


Exploring Underrepresented Stem Undergraduates' Stem Identity Development: The Role Of Social Partners, Sandy Cerda-Lezama Sep 2025

Exploring Underrepresented Stem Undergraduates' Stem Identity Development: The Role Of Social Partners, Sandy Cerda-Lezama

Dissertations and Theses

This dissertation employs a three-study qualitative design to investigate the role of mentorship and social interaction in the identity development of racial minority undergraduate students in STEM disciplines. Grounded in Communities of Practice theory, this research amplifies student narratives to elucidate the relational and contextual factors that inform science identity, belonging, competence, and persistence in higher education. Study One draws upon interview data from fifteen participants in the BUILD program to analyze the role of recognition, particularly from expert scientists--in students' science identity development. This study aims to understand how racial and ethnic identity intersections influence the processes and impact …


Associations Between Adhering To 24-Hour Movement Guidelines And Anxiety Among Adolescents Across Intersectional Identities: Kyrbs 2020-2022., Suryeon Ryu, Eun Young Lee, Zan Gao Sep 2025

Associations Between Adhering To 24-Hour Movement Guidelines And Anxiety Among Adolescents Across Intersectional Identities: Kyrbs 2020-2022., Suryeon Ryu, Eun Young Lee, Zan Gao

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Identifying preventive measures for adolescent mental health is a global public health priority, as poor mental health heightens the risk of early death from related issues, including suicide. This study examined the associations between adherence to the 24-Hour Movement Guidelines and anxiety among a nationally representative sample of South Korean adolescents, using an intersectional identity framework.

METHODS: Data from the 2020-2022 Korea Youth Risk Behavior Surveys were analyzed. Adolescents aged 12-17 years were grouped based on adherence to guidelines: none, physical activity (PA), sedentary behavior (SB), sleep, two guideline combinations, and all three. Anxiety was the mental health outcome. …


Association Of Genetic Scores Related To Insulin Resistance With Neurological Outcomes In Ancestrally Diverse Cohorts From The Trans-Omics For Precision Medicine (Topmed) Program, Chloé Sarnowski, Yixin Zhang, Farah Ammous, Lincoln M P Shade, Daniel Dicorpo, Xueqiu Jian, Donna K Arnett, Thomas R Austin, Alexa Beiser, Joshua C Bis, John Blangero, Eric Boerwinkle, Jan Bressler, Joanne E Curran, Charles S Decarli, Harsha Doddapaneni, Josée Dupuis, David W Fardo, Jose C Florez, Stacey Gabriel, Richard A Gibbs, David C Glahn, Namrata Gupta, Hector M González, Kevin A González, Konstantinos Hatzikotoulas, Kathleen M Hayden, Susan R Heckbert, Bertha Hidalgo, Alicia Huerta-Chagoya, Timothy M Hughes, Sharon L R Kardia, Charles L Kooperberg, Lenore J Launer, W T Longstreth, Ravi Mandla, Rasika A Mathias, Andrew P Morris, Thomas H Mosley, Ilya M Nasrallah, Paul Nyquist, Bruce M Psaty, Qibin Qi, Laura M Raffield, Nigel W Rayner, Alexander P Reiner, Claudia L Satizabal, Elizabeth Selvin, Magdalena D R Sevilla-Gonzalez, Albert V Smith, Jennifer A Smith, Kirk Smith, Beverly M Snively, Lorraine Southam, Tamar Sofer, Ken Suzuki, Henry J Taylor, Miriam S Udler, Karine A Viaud-Martinez, Sylvia Wassertheil-Smoller, Alexis C Wood, Lisa R Yanek, Xianyong Yin, Alisa K Manning, Jerome I Rotter, Stephen S Rich, James B Meigs, Myriam Fornage, Sudha Seshadri, Alanna C Morrison, Topmed Neurocognitive Working Group, Topmed Diabetes Working Group Sep 2025

Association Of Genetic Scores Related To Insulin Resistance With Neurological Outcomes In Ancestrally Diverse Cohorts From The Trans-Omics For Precision Medicine (Topmed) Program, Chloé Sarnowski, Yixin Zhang, Farah Ammous, Lincoln M P Shade, Daniel Dicorpo, Xueqiu Jian, Donna K Arnett, Thomas R Austin, Alexa Beiser, Joshua C Bis, John Blangero, Eric Boerwinkle, Jan Bressler, Joanne E Curran, Charles S Decarli, Harsha Doddapaneni, Josée Dupuis, David W Fardo, Jose C Florez, Stacey Gabriel, Richard A Gibbs, David C Glahn, Namrata Gupta, Hector M González, Kevin A González, Konstantinos Hatzikotoulas, Kathleen M Hayden, Susan R Heckbert, Bertha Hidalgo, Alicia Huerta-Chagoya, Timothy M Hughes, Sharon L R Kardia, Charles L Kooperberg, Lenore J Launer, W T Longstreth, Ravi Mandla, Rasika A Mathias, Andrew P Morris, Thomas H Mosley, Ilya M Nasrallah, Paul Nyquist, Bruce M Psaty, Qibin Qi, Laura M Raffield, Nigel W Rayner, Alexander P Reiner, Claudia L Satizabal, Elizabeth Selvin, Magdalena D R Sevilla-Gonzalez, Albert V Smith, Jennifer A Smith, Kirk Smith, Beverly M Snively, Lorraine Southam, Tamar Sofer, Ken Suzuki, Henry J Taylor, Miriam S Udler, Karine A Viaud-Martinez, Sylvia Wassertheil-Smoller, Alexis C Wood, Lisa R Yanek, Xianyong Yin, Alisa K Manning, Jerome I Rotter, Stephen S Rich, James B Meigs, Myriam Fornage, Sudha Seshadri, Alanna C Morrison, Topmed Neurocognitive Working Group, Topmed Diabetes Working Group

The Brown Foundation: Institute of Molecular Medicine

To better characterize the potential biological mechanisms underlying insulin resistance (IR) and dementia, we derive cross-population and population specific polygenic scores [PSs] for fasting insulin and IR-related partitioned PSs [pPSs]. We conduct a cross-sectional study of the associations of these genetic scores with neurological outcomes in >17k participants (36% men, mean age 55 yrs) from the Trans-Omics for Precision Medicine (TOPMed) program (50% Non-Hispanic White, 23% Black/African American, 21% Hispanic/Latino American, and 4% Asian American). We report significant negative associations (P <  0.002) of the cross-population (P = 1.3 × 10-5) and European (PEA = 3.0 × 10-8) fasting insulin PSs with total cranial volume, and of a metabolic syndrome European PS with general cognitive function (BEA = -0.13, PEA = 0.0002) and lateral ventricular volume (BEA = 0.09, PEA = 0.002). We identify suggestive negative associations (P <  0.007) of metabolic syndrome and obesity pPSs with general cognitive function, and of lipodystrophy pPSs with total cranial volume. A higher genetic predisposition to IR is associated with lower brain size, and a genetic predisposition to specific IR-related type 2 diabetes subtypes, such as metabolic syndrome and mechanisms of IR mediated through obesity and lipodystrophy, is potentially involved in cognitive decline.