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Insider Threat: A Case Study Of The Maroochy Water Services Attack, Samuel Rector Nov 2025

Insider Threat: A Case Study Of The Maroochy Water Services Attack, Samuel Rector

Cybersecurity Undergraduate Research Showcase

In 2000, a former employee at Hunter Watertech went rogue and caused a spill of 800,000 liters of sewage. He leveraged his insider knowledge and access to stolen equipment in order to seek retribution for the company that wronged him. After three months of torment police arrested him and an investigation and many studies were done on the incident. A consensus remains that much of this chaos was preventable with simple cybersecurity implementations.


Parents’ Sustained Recovery From Substance Use During The Coronavirus Pandemic, Amanda Antis Nov 2025

Parents’ Sustained Recovery From Substance Use During The Coronavirus Pandemic, Amanda Antis

Walden Dissertations and Doctoral Studies

Parents in recovery from substance abuse rely on social support and programs to maintain their sobriety consistently. However, specific programs crucial for their social and mental well-being, such as most 12-step groups and recovery centers, were shut down during the COVID-19 pandemic. Despite some research on the impact of substance abuse during the pandemic, little attention has been given to sustained recovery. Therefore, the purpose of this descriptive qualitative study was to explore how parents maintained recovery from substance use amid the COVID-19 pandemic. Schlossberg’s transition process model served as the theoretical framework for this study. Semistructured interviews with nine …


Kenyon Collegian - November 20, 2025 Nov 2025

Kenyon Collegian - November 20, 2025

The Kenyon Collegian

No abstract provided.


Partnering For International Student Success: Opportunities For Academic Librarians And Esl Faculty To Support Research And Information Literacy Skills, Rachel E. Trnka Nov 2025

Partnering For International Student Success: Opportunities For Academic Librarians And Esl Faculty To Support Research And Information Literacy Skills, Rachel E. Trnka

Faculty Scholarship and Creative Works

Presentation at the Graduate Student Forum of the TESOL Virtual Conference

With the growing number of international students attending American universities in recent years, academic librarians recognize the importance of serving the needs of that population. However, many librarians acknowledge that they feel unprepared to support international students, due to a lack of training or experience working with multilingual or second-language learners. This presentation offers a review of the literature exploring collaborations between librarians and instructors to better support ELLs in a college and university setting and presents recommendations for both librarians and faculty. While this session focuses on academic …


Transnational Networks Of Film Repetitions In East Asia : Proliferation And Limitations, Roman Kusaiko Nov 2025

Transnational Networks Of Film Repetitions In East Asia : Proliferation And Limitations, Roman Kusaiko

Lingnan Theses (MPhil & PhD)

A growing number of contemporary film critics, influencers, and audiences criticize film remaking, a tested and successful Hollywood practice. The main complaints are a lack of originality, overreliance on repeated titles, and an openly commercial nature. Despite criticism, film remakes have existed for decades and are a vivid and resilient form of recycling under new cultural and geopolitical circumstances. Contemporary film remaking reflects the impacts of globalization, transnationalization, and the rapid development of new media and digitalization.

Nevertheless, there is a tendency to theorize on film remaking, often relying on the dichotomy of the source and a remake or, less …


Hpv Prevention In Men: A Narrative Review Of Strategies, Risks, And Public Health Implications, Martin S. Lipsky, Bayler Gunnell, Justin Nguyen, Samantha Lee, Geo Wolfe, Man Hung Nov 2025

Hpv Prevention In Men: A Narrative Review Of Strategies, Risks, And Public Health Implications, Martin S. Lipsky, Bayler Gunnell, Justin Nguyen, Samantha Lee, Geo Wolfe, Man Hung

Institute on Aging Publications

Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide, impacting both males and females. In men, HPV causes genital warts, more than 90% of anal cancers, and 60% of oropharyngeal cancers. Given that one in three men are infected with HPV worldwide, there is a pressing need for enhanced public health strategies focusing on prevention. This comprehensive narrative review presents an overview of HPV in men, key risk factors, and primary prevention in men. The most effective preventive measure for HPV in males is vaccination. Males at high risk for HPV include those who smoke, have human immunodeficiency …


Powering Up Clinical Scholarship In Dental Medicine, Evelyn Wang Nov 2025

Powering Up Clinical Scholarship In Dental Medicine, Evelyn Wang

HSLIC Faculty and Staff Instructional Resources

This presentation is designed for Dental Medicine Journal Club attendees, focusing on developing clinical scholarship skills. Key topics include research question formation (PICOT, FAC Rubric), dental resources navigation (PubMed, EMBASE, BrowZine, open data repositories), advanced literature search techniques (Boolean operators, truncation, wildcards, proximity operators, subject headings), full-text access tools (LibKey Nomad, interlibrary loan), critical appraisal tools (CASP, JBI, PRISMA-S), publishing workflow (Zotero, ORCID, open access publishing), and a summary of HSLIC educational and research support services. The session aims to equip dental residents to engage in evidence-based scholarship and professional growth.


Mark Robertson, Mark Robertson, Esther Hewitt Nov 2025

Mark Robertson, Mark Robertson, Esther Hewitt

Oral Histories of Farming along the Middle Rio Grande

No abstract provided.


Chris Chavez, Chris Chavez Nov 2025

Chris Chavez, Chris Chavez

Oral Histories of Farming along the Middle Rio Grande

No abstract provided.


Converging On The Cepheid Metallicity Dependence: Implications Of Nonstandard Gaia Parallax Recalibration On Distance Measures, Louise Breuval, Gagandeep S. Anand, Richard I. Anderson, Rachael Beaton, Anupam Bhardwaj, Stefano Casertano, Gisella Clementini, Mauricio Cruz Reyes, Giulia De Somma, Lucas M. Macri Nov 2025

Converging On The Cepheid Metallicity Dependence: Implications Of Nonstandard Gaia Parallax Recalibration On Distance Measures, Louise Breuval, Gagandeep S. Anand, Richard I. Anderson, Rachael Beaton, Anupam Bhardwaj, Stefano Casertano, Gisella Clementini, Mauricio Cruz Reyes, Giulia De Somma, Lucas M. Macri

Physics & Astronomy Faculty Publications

By comparing Cepheid brightnesses with geometric distance measures including Gaia EDR3 parallaxes, most recent analyses conclude metal-rich Cepheids are brighter, quantified as γ ∼ −0.2 mag dex−1 . While the value of γ has little impact on the determination of the Hubble constant in contemporary distance ladders (due to the similarity of metallicity across these ladders), γ plays a role in gauging the distances to metal-poor dwarf galaxies like the Magellanic Clouds and is of considerable interest in testing stellar models. Recently, B. F. Madore & W. L. Freedman (hereafter MF25) recalibrated Gaia EDR3 parallaxes by adding to them a …


Alvin Levon Lovett Nov 2025

Alvin Levon Lovett

African American Funeral Programs

No abstract provided.


Readers Are Authors, Especially In The Ai Age, Jessica Silbey Nov 2025

Readers Are Authors, Especially In The Ai Age, Jessica Silbey

Faculty Scholarship

In this essay, Abraham Drassinower updates the argument in his 2015 book What’s Wrong With Copying (Harvard University Press) with an elaboration of the nature of copyright’s public domain: it is a domain of unauthorized yet lawful copying. As in his book, Drassinower explains that the public domain is not properly understood as a problem of balancing between copyright’s public benefits and private rewards. Instead, he understands the public domain as part of authorship and thus inseparable from copyright’s construction.


Expanding Our Ir After Health System Combination: Nurses Lead The Way, Jennifer Deal, Karen Hanus Nov 2025

Expanding Our Ir After Health System Combination: Nurses Lead The Way, Jennifer Deal, Karen Hanus

All Other Contributions

No abstract provided.


Assessing The Usability Of A Novel Toolkit For Creating Visual Key Information Pages For Informed Consent For Research: Mixed Methods Usability Study, Eliana Charlotte Goldstein, Zoe Troubh, Krista E Cooksey, Molly Volkmar, Victor Catalan Gallegos, Kimberly A Kaphingst, Clara N Lee, Ashley J Housten, Jessica Mozersky, Mary C Politi Nov 2025

Assessing The Usability Of A Novel Toolkit For Creating Visual Key Information Pages For Informed Consent For Research: Mixed Methods Usability Study, Eliana Charlotte Goldstein, Zoe Troubh, Krista E Cooksey, Molly Volkmar, Victor Catalan Gallegos, Kimberly A Kaphingst, Clara N Lee, Ashley J Housten, Jessica Mozersky, Mary C Politi

2020-Current year OA Pubs

BACKGROUND: Key information pages for informed consent require a concise summary of information to improve participant understanding but have not widely incorporated health literacy best practices.

OBJECTIVE: We previously developed a visual key information template to improve informed consent. In this study, we conducted usability testing of this customizable one-page key information template.

METHODS: We used the Designing for Accelerated Translation framework to plan for actionable, efficient usability testing. Participants (N=15) were asked to spend about 20 minutes using the visual key information template and engaging in a think-aloud protocol. They then responded to qualitative debrief questions about the template …


Mu-Glioma Post: A Comprehensive Dataset Of Automated Mr Multi-Sequence Segmentation And Clinical Features, Esmat Mahmoud, Jaime Gass, Yaseen Dhemesh, Josh Greaser, Karolina Pogorzelski, Edvin Isufi, Filip Garrett, Jonathan Thacker, Nourel Hoda Tahon, Jason Sinclair, Lester Layfield, Talissa Altes, Ayman Nada Nov 2025

Mu-Glioma Post: A Comprehensive Dataset Of Automated Mr Multi-Sequence Segmentation And Clinical Features, Esmat Mahmoud, Jaime Gass, Yaseen Dhemesh, Josh Greaser, Karolina Pogorzelski, Edvin Isufi, Filip Garrett, Jonathan Thacker, Nourel Hoda Tahon, Jason Sinclair, Lester Layfield, Talissa Altes, Ayman Nada

2020-Current year OA Pubs

Gliomas represent a heterogenous group of primary brain tumors with overlapping imaging phenotypes. Treatment typically includes surgery and/or chemoradiation, however this varies based on the overall lesion and clinical presentation. This heterogeneity in both lesion characteristics and management strategies contributes to a lack of reliable findings when evaluating treatment outcomes with conventional MRI. The overlapping imaging features of radiation necrosis and tumor progression post-treatment can be particularly challenging for radiologists. We present a dataset of 203 glioma patients with 594 post-treatment timepoints of relevant clinical history and routine T1, T1 postcontrast, T2, and FLAIR weighted MR sequences. Preprocessing of the …


Modulation Of Dorsal Hippocampal Sk2 Channels Regulates Morphine-Enhanced Neuronal Oscillations And Morphine-Induced Contextual Memory Encoding And Retrieval, Khairunisa Mohamad Ibrahim, Dominika J Burek, Azra Zec, Olayinka Idowu, Will W Post, Alice Zheng, Basma Daham, Justin D Meyer, Sidney Williams, Nicolas Massaly, Jose A Morón Nov 2025

Modulation Of Dorsal Hippocampal Sk2 Channels Regulates Morphine-Enhanced Neuronal Oscillations And Morphine-Induced Contextual Memory Encoding And Retrieval, Khairunisa Mohamad Ibrahim, Dominika J Burek, Azra Zec, Olayinka Idowu, Will W Post, Alice Zheng, Basma Daham, Justin D Meyer, Sidney Williams, Nicolas Massaly, Jose A Morón

2020-Current year OA Pubs

Persistent maladaptive drug-context associations are a key component of relapse vulnerability and pose a major obstacle in treating opioid use disorder. Although the dorsal hippocampus (dHPC) is critical for contextual memory formation, the synaptic mechanisms by which opioids alter hippocampal circuits to sustain these associations remain unclear. We previously found that repeated context-paired morphine exposure impairs dHPC long-term potentiation (LTP) through enhanced activity of small-conductance calcium-activated potassium (SK2) channels. Here, we investigated the role of SK2 channels in morphine-context associative learning and memory by combining in vivo electrophysiology, molecular analyses, and behavioral pharmacology with the morphine-conditioned place preference (MorCPP) paradigm …


November 20, 2025, The Daily Mississippian Nov 2025

November 20, 2025, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.


Neurocomunicación Del Espacio: Experiencia Multisensorial Y Bienestar [Ponencia] Iv Congreso Internacional De Neurocomunicación Y Neuromarketing (Cinyn 2025), María Beltrán Rodríguez, Alejandro Martínez González, Ivette Caldelas, Chloe Sharpe Nov 2025

Neurocomunicación Del Espacio: Experiencia Multisensorial Y Bienestar [Ponencia] Iv Congreso Internacional De Neurocomunicación Y Neuromarketing (Cinyn 2025), María Beltrán Rodríguez, Alejandro Martínez González, Ivette Caldelas, Chloe Sharpe

Congresos y Conferencias

No abstract provided.


Parentcoach: Designing An Mhealth Parenting App To Enhance Parental Involvement In Adhd Support, Franceli L. Cibrian, Nancy Herrera, Jesus A. Beltran, Lucas M. Silva, Mikaela Pulse, Kayla Anderson, Cassie Zeiler, Luc Rieffel, Daniel I. Lee, Sabrina E. B. Schuck, Kimberley D. Lakes Nov 2025

Parentcoach: Designing An Mhealth Parenting App To Enhance Parental Involvement In Adhd Support, Franceli L. Cibrian, Nancy Herrera, Jesus A. Beltran, Lucas M. Silva, Mikaela Pulse, Kayla Anderson, Cassie Zeiler, Luc Rieffel, Daniel I. Lee, Sabrina E. B. Schuck, Kimberley D. Lakes

Engineering Faculty Articles and Research

Introduction: Parents play a vital role in supporting self-regulation and managing behaviors in children with Attention-Deficit/Hyperactivity Disorder (ADHD). However, many face barriers to accessing consistent, evidence-based support. Mobile health (mHealth) technologies offer a promising way to deliver flexible, low-burden guidance for parents on best practices and strategies to support their children's self-regulation. However, designing them is non-trivial.

Objective: This paper introduces ParentCoach, a mobile application designed to support parents of children with ADHD through brief daily lessons, reflection prompts, and skill-building activities.

Methods: ParentCoach was developed in two phases: (1) secondary analysis of qualitative data from over 30 families …


Native American Film Screening | Ixcanul, Language Learning Center Nov 2025

Native American Film Screening | Ixcanul, Language Learning Center

LAII Events

Thursday, November 20, 2025 | 03:00 pm

Language Learning Center | Ortega Hall

About:

Join the LLC for a showing Ixcanul (2015). This film focuses on a young Kaqchikel Maya woman in rural Guatemala facing a tension between tradition and modernity. See the flyer for more details.

Notes:

This event is free and open to the public.


Ai-Powered Prediction Of Co2 Dissolution In Seawater For Enhanced Carbon Capture Efficiency, Arthur Frot Berthelot Nov 2025

Ai-Powered Prediction Of Co2 Dissolution In Seawater For Enhanced Carbon Capture Efficiency, Arthur Frot Berthelot

Electronic Theses and Dissertations 2020 - Present

Climate change remains one of the most pressing global challenges, with carbon dioxide (CO2) emissions playing a crucial role in exacerbating global warming and ocean acidification. Among emerging mitigation strategies, carbon capture and storage (CCS) stands out as a promising solution. This dissertation explores a novel carbon capture approach utilizing seawater and nickel nanoparticles (NiNPs) stabilized by carboxymethylcellulose (CMC) to enhance CO2 dissolution. Unlike conventional amine-based methods, which are resource-intensive and reliant on freshwater, this approach offers a more sustainable and environmentally friendly alternative. To address the high cost and complexity of experimental CO2 capture studies, a predictive artificial intelligence …


Microcrystalline Wax Lab Scale Assessment As Corrosion Protection In Post Tensioning Construction Systems, Supriya Share Nov 2025

Microcrystalline Wax Lab Scale Assessment As Corrosion Protection In Post Tensioning Construction Systems, Supriya Share

Electronic Theses and Dissertations 2020 - Present

The primary focus of this project is to assess the effectiveness of five different flexible fillers in preventing corrosion-induced failures, particularly when exposed to water and chloride containing solutions. The specimens tested are single steel wires that ranged from (12-16cm) in length and 7 mm in diameter.

Samples are monitored to study the impact of factors like water and chloride solution concentration to identify when and which one could cause corrosion to initiate when the steel wires are coated with different flexible fillers. The goal is to identify the types of flexible fillers that protect the steel wires from corroding …


Thankful Table, Chartwells Nov 2025

Thankful Table, Chartwells

Miscellaneous Campus Flyers

Thursday, November 20, 2025


Evaluation Of Six Roma Tomato Cultivars In Southwest Michigan In 2025, Ben Phillips Nov 2025

Evaluation Of Six Roma Tomato Cultivars In Southwest Michigan In 2025, Ben Phillips

Midwest Vegetable Trial Reports

A Roma tomato cultivar trial was planted at the Southwest Michigan Research and Extension Center (42.081985, -86.354087, Benton Harbor, Michigan). HM Clause (HM), Lark (LK), and Sakata (SK) seed companies donated 6 cultivars for plastic mulch-bedded hand harvest. Overall, the trial quality was good, with periods of high heat slowing ripening.


Evaluation Of Nine Sh2 Sweet Corn Cultivars In Southwest Michigan In 2025, Ben Phillips Nov 2025

Evaluation Of Nine Sh2 Sweet Corn Cultivars In Southwest Michigan In 2025, Ben Phillips

Midwest Vegetable Trial Reports

A bicolor sh2 sweet corn cultivar trial was planted at the Southwest Michigan Research and Extension Center (42.081985, -86.354087, Benton Harbor, Michigan). Seeds were donated by Crookham (CK), and Rupp (RP) seed companies. Two synergistic varieties were donated by Chris Difonzo from the Bt resistance project and were treated as unsprayed late-season checks against caterpillar infestation. Overall trial conditions were hot and dry, with moisture stress throughout the trial on a sandy hill. Overhead irrigation provided some relief. A new seeder was used that planted at a lower population than desired. As such, yield suffered in this trial.


Chelsea Gallery Walk + Happy Hour After, Cardozo Art Law Society, Cardozo Fame Center Nov 2025

Chelsea Gallery Walk + Happy Hour After, Cardozo Art Law Society, Cardozo Fame Center

2025–2026 Flyers

No abstract provided.


Tca Cycle Mode Switch Determines The Fate Of Pirtobrutinib-Tolerant Persister Cells In Mantle Cell Lymphoma, Wei Wang, Qingsong Cai, Yang Liu, Lei Nie, Heng-Huan Lee, Yue Fei, Yijing Li, Lin Tan, Philip L Lorenzi, Ying-Nai Wang, Jun Yao, Zhihong Chen, Joseph Mitchell Mcintosh, Cheng-Tai Yu, Preetesh Jain, Vivian C Jiang, Jovanny Vargas, Xiaolin Li, Tianci Zhang, Shaoying Li, David Santos, Selvi Thirumurthi, Erin Heather Seeley, Lukas Mikolaj Simon, Christopher Flowers, Chi Young Ok, Michael Wang Nov 2025

Tca Cycle Mode Switch Determines The Fate Of Pirtobrutinib-Tolerant Persister Cells In Mantle Cell Lymphoma, Wei Wang, Qingsong Cai, Yang Liu, Lei Nie, Heng-Huan Lee, Yue Fei, Yijing Li, Lin Tan, Philip L Lorenzi, Ying-Nai Wang, Jun Yao, Zhihong Chen, Joseph Mitchell Mcintosh, Cheng-Tai Yu, Preetesh Jain, Vivian C Jiang, Jovanny Vargas, Xiaolin Li, Tianci Zhang, Shaoying Li, David Santos, Selvi Thirumurthi, Erin Heather Seeley, Lukas Mikolaj Simon, Christopher Flowers, Chi Young Ok, Michael Wang

Faculty, Staff and Student Publications

Bruton tyrosine kinase inhibitors (BTKis) and cell therapy have successfully been used to treat mantle cell lymphoma (MCL). However, therapy resistance inevitably emerges. Cancer cells can progressively develop stable resistance by traversing through a transient drug-tolerant persister (DTP) state. The mechanisms enabling DTP cells to reversibly adapt to therapies and evolve to acquire heterogeneity remain poorly understood, and characterizing DTP cells in MCL continues to pose a challenge for clinic translation. Here, using pirtobrutinib, a recently US Food and Drug Administration-approved noncovalent BTKi, we identified pirtobrutinib-tolerant persister cells exhibiting morphological variability by presenting a unique population of enlarged cells (giant …


Acute Myeloid Leukemia With T(10; 17)(P15; Q21)/ Zmynd11::Mbtd1: A Subtype With Minimal Differentiation, Cd7/Cd56 Expression, And Generally Poor Outcomes In Adults, Qing Wei, Naveen Pemmaraju, Sa A Wang, Shimin Hu, Courtney Dinardo, Carlos E Bueso-Ramos, Shaoying Li, Jeffrey L Medeiros, Guilin Tang Nov 2025

Acute Myeloid Leukemia With T(10; 17)(P15; Q21)/ Zmynd11::Mbtd1: A Subtype With Minimal Differentiation, Cd7/Cd56 Expression, And Generally Poor Outcomes In Adults, Qing Wei, Naveen Pemmaraju, Sa A Wang, Shimin Hu, Courtney Dinardo, Carlos E Bueso-Ramos, Shaoying Li, Jeffrey L Medeiros, Guilin Tang

Faculty, Staff and Student Publications

No abstract provided.


Early Tumor Volume Reduction By Breast Dce Mri Predicts Pathologic Complete Response To Neoadjuvant Therapy In Triple Negative Breast Cancer, Mary S Guirguis, Beatriz E Adrada, Clinton Yam, Debu Tripathy, Rosalind Candelaria, Miral Patel, Frances Perez, Gary J Whitman, Jessica W T Leung, Huong Le-Petross, Deanna L Lane, Lei Huo, Jennifer K Litton, Vicente Valero, Kelly K Hunt, Banu Arun, Rania Mohamed, Jia Sun, Anil Korkut, Zhan Xu, Sanaz Pashapoor, Jason White, Jong Bum Son, Alastair Thompson, Peng Wei, Jingfei Ma, Stacy Moulder, Gaiane M Rauch Nov 2025

Early Tumor Volume Reduction By Breast Dce Mri Predicts Pathologic Complete Response To Neoadjuvant Therapy In Triple Negative Breast Cancer, Mary S Guirguis, Beatriz E Adrada, Clinton Yam, Debu Tripathy, Rosalind Candelaria, Miral Patel, Frances Perez, Gary J Whitman, Jessica W T Leung, Huong Le-Petross, Deanna L Lane, Lei Huo, Jennifer K Litton, Vicente Valero, Kelly K Hunt, Banu Arun, Rania Mohamed, Jia Sun, Anil Korkut, Zhan Xu, Sanaz Pashapoor, Jason White, Jong Bum Son, Alastair Thompson, Peng Wei, Jingfei Ma, Stacy Moulder, Gaiane M Rauch

Faculty, Staff and Student Publications

Triple-negative breast cancer (TNBC) is a heterogeneous disease with variable response to neoadjuvant systemic therapy (NAST). Patients with pathologic complete response (pCR) following NAST have improved survival. Our goal was to establish readily accessible imaging biomarker to identify which TNBC patients will have pCR. Building on prior favorable results in the literature, we hypothesized that manually measured tumor volume changes at DCE-MRI may predict pCR early during NAST. This prospective study included 287 stage I-III TNBC patients who underwent DCE-MRI at baseline, after two and four cycles of NAST, with pCR accessed at surgery (NCT02276443). Tumor volume and percentage tumor …


Five-Year Follow-Up Analysis Of Zuma-5: Axicabtagene Ciloleucel In Relapsed/Refractory Indolent Non-Hodgkin Lymphoma, Sattva S Neelapu, Julio C Chavez, Alison R Sehgal, Narendranath Epperla, Matthew L Ulrickson, Pashna N Munshi, David G Maloney, Sven De Vos, Ran Reshef, Lori A Leslie, Olalekan O Oluwole, Ibrahim Yakoub-Agha, Rashmi Khanal, Joseph D Rosenblatt, Jacob Wulff, Rhine R Shen, Wangshu Zhang, Soumya Poddar, Harry Miao, Olga Nikolajeva, Caron A Jacobson Nov 2025

Five-Year Follow-Up Analysis Of Zuma-5: Axicabtagene Ciloleucel In Relapsed/Refractory Indolent Non-Hodgkin Lymphoma, Sattva S Neelapu, Julio C Chavez, Alison R Sehgal, Narendranath Epperla, Matthew L Ulrickson, Pashna N Munshi, David G Maloney, Sven De Vos, Ran Reshef, Lori A Leslie, Olalekan O Oluwole, Ibrahim Yakoub-Agha, Rashmi Khanal, Joseph D Rosenblatt, Jacob Wulff, Rhine R Shen, Wangshu Zhang, Soumya Poddar, Harry Miao, Olga Nikolajeva, Caron A Jacobson

Faculty, Staff and Student Publications

Axicabtagene ciloleucel (axi-cel) is an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy approved for relapsed/refractory (R/R) follicular lymphoma (FL). Here, we report updated clinical outcomes from ZUMA-5 in 159 enrolled patients with R/R indolent non-Hodgkin lymphoma (iNHL; 127 with FL and 31 with marginal zone lymphoma) after a median follow-up of 64.6 months. Patients underwent leukapheresis and received lymphodepleting chemotherapy and axi-cel (2 × 106 CAR T cells/kg). The overall response rate was 90% (75% complete response rate). The median duration of response was 60.4 months, and the median progression-free survival (PFS) was 62.2 months; median time to next …