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An Essay On Trailblazing With Service Animals Langer, Pilot, Bowie, And Izzie: Preserving Non-Partisan Public Health And The Law, Gary C. Norman Nov 2025

An Essay On Trailblazing With Service Animals Langer, Pilot, Bowie, And Izzie: Preserving Non-Partisan Public Health And The Law, Gary C. Norman

Journal of Law and Health

A direct correlation exists among humans, their animals, and human health and wellness. This article will focus concisely on law students with disabilities and lawyers with disabilities and how they can be empowered to be trailblazers while remaining healthy and well. Salutogenic Model should be optimized by lawyers with disabilities working at the intersection of animal law, disability law, and public health law. Service animals have positive and salubrious impacts upon their handlers in several ways, including psychosocial health and wellbeing. The Grand Architect (or in my Cherokee tradition, "great spirit") continuously partners me with complicated but magnificent dog partners …


Addressing Health-Related Social Needs With Innovative Healthcare Spending, Kelly Naranjo Ms Ccrc, Eric Rochman Mph, Allyson Schiff Ba, Dorella Walters Mpa, Andrea Zaldivar Ed.D, Ms, Anp Nov 2025

Addressing Health-Related Social Needs With Innovative Healthcare Spending, Kelly Naranjo Ms Ccrc, Eric Rochman Mph, Allyson Schiff Ba, Dorella Walters Mpa, Andrea Zaldivar Ed.D, Ms, Anp

Journal of Law and Health

Key objectives: To address the social determinants of health domains "social and community context" and "neighborhood and built environment" via Medically Tailored Meals, a nutrition intervention that includes home delivery, medical nutrition therapy and education, and frozen medically tailored meals provided by the non-profit partner. This intervention targeted Medicaid members exhibiting high healthcare utilization in conjunction with each individual's risk of developing higher morbidity and mortality of existing disease due to co-existing food and nutrition insecurity. The populations served include people living with Type 2 Diabetes, Hypertension, Cardiovascular Disease, Cancer, HIV/AIDS, and End-Stage Renal Disease, among other conditions, whose burden …


Access To Healthcare For Irregular Migrants, Jessica Dykes Nov 2025

Access To Healthcare For Irregular Migrants, Jessica Dykes

Journal of Law and Health

Access to Healthcare for Irregular Migrants is an assessment of the right to life, security of the person, and non-discrimination as viewed through the lens of Nell Toussaint's legal battle. It tells the compelling story of an irregular migrant's battle for access to health care. Highlighting a gap in the Canadian healthcare system, this piece raises valuable questions about why that gap exists. Toussaint's experiences with multiple levels of the legal system, both in Canada and internationally, are included. It tells the story from when Ms. Toussaint entered Canada to the present; wherein the matter remains before the court.

This …


Madagascar's Urban Lemur Meat Trade, Cortni Borgerson, Be Noel Razafindrapaoly, Be Jean Rodolph Rasolofoniaina Nov 2025

Madagascar's Urban Lemur Meat Trade, Cortni Borgerson, Be Noel Razafindrapaoly, Be Jean Rodolph Rasolofoniaina

Department of Anthropology Faculty Scholarship and Creative Works

As the world's most endangered mammals, lemurs are key to understanding how humans and wildlife can sustainably coexist. We present the first national assessment of the urban lemur meat trade. We interviewed 2600 participants across 17 cities to determine its scale, target species, distribution, and drivers. We reveal a considerable trade, with thousands of threatened lemurs sold annually. This trade is largely hidden, with 95% of sales occurring directly between suppliers and a trusted clientele, and targets some of the nation's most endangered species, often during critical breeding seasons. While entrepreneurial peri-urban suppliers are lured by a dependable economic opportunity, …


Economic Convergence, Intragenerational Economic Mobility, And Inequality In A Native Amazonian Small-Scale Society Of Indigenous People In Bolivia, Ricardo Godoy, Jonathan Bauchet, Victoria Reyes-Garcia, Eduardo A. Undurraga Nov 2025

Economic Convergence, Intragenerational Economic Mobility, And Inequality In A Native Amazonian Small-Scale Society Of Indigenous People In Bolivia, Ricardo Godoy, Jonathan Bauchet, Victoria Reyes-Garcia, Eduardo A. Undurraga

Department of Agricultural Economics Faculty Publications

Adult intragenerational mobility reflects society’s ability to reward effort and tame society-wide inequality. In developed economies, mobility is modest and correlates negatively with economic inequality. Little is known quantitatively from direct observations about long-term intragenerational mobility in small-scale societies of the Global South. To assess the external validity of findings about patterns of intragenerational mobility from developed economies, we use a yearly survey panel dataset (2002–2010) of adults from a society of native Amazonians (Tsimane’) in Bolivia practicing farming, fishing, hunting, and plant gathering. We estimate (a) convergence rates (or the speed of catch up) of adults in the bottom …


Renewal Of The Mind: Forgiveness Through The Lens Of Christian Faith And Neuroscience, Khelen Walsh Nov 2025

Renewal Of The Mind: Forgiveness Through The Lens Of Christian Faith And Neuroscience, Khelen Walsh

University Honors Theses

Within Christian theology, forgiveness is a foundational concept that is often understood as a divine command, a spiritual practice, and a path toward reconciliation and personal growth. Recent neuroscientific research further supports this viewpoint, providing data that shows forgiveness engages neural systems responsible for emotional regulation, empathy, moral reasoning, and perspective-taking. Through neuroplasticity, repeated acts of forgiveness reshape the brain, strengthen connections between prefrontal and limbic regions, reduce amygdala reactivity, and enhance emotional stability and cognitive flexibility. Although forgiveness offers many benefits, modern culture frequently distorts its meaning, framing it as a sign of weakness, gullibility, or a form of …


Christopher Devan Pryor Nov 2025

Christopher Devan Pryor

African American Funeral Programs

No abstract provided.


Forage Mass And Botanical Composition Of Four Annual Forages Grown In A Loblolly Pine Silvopasture In The Mid-South Usa, Christine C. Nieman, Dirk Philipp, Jonathan O.C. Kubesch Nov 2025

Forage Mass And Botanical Composition Of Four Annual Forages Grown In A Loblolly Pine Silvopasture In The Mid-South Usa, Christine C. Nieman, Dirk Philipp, Jonathan O.C. Kubesch

Animal Science Faculty Publications and Presentations

Annual forages are commonly planted in open pasture in the Mid-South, but there is little information on the productivity of these forages when incorporated into silvopasture. The objective was to evaluate four annual forages adapted to the Mid-South, namely, arrowleaf clover (Trifolium vesiculosum Savi), crimson clover (Trifolium incarnatum L.), tetraploid annual ryegrass (Lolium multiflorum L.), and diploid annual ryegrass (Lolium multiflorum L.), in a loblolly pine (Pinus taeda L.) silvopasture for seasonal forage mass distribution and annual forage accumulation. The forages were tested in a randomized complete block design with three replicates and three harvests per year: Harvest 1 (H1, …


Evaluating The Effectiveness Of Clinical Practice Guideline Adherence For Patellofemoral Pain (Knee-Capp): Protocol For A Multisite, Parallel-Arm Randomized Clinical Trial In The Military Health System, Emma H. Beisheim-Ryan, Timothy C. Mauntel, Daniel I. Rhon, Charity G. Patterson, Nathan Parsons, Scott Paradise, Megan H. Roach, Marisa Pontillo, Sara R. Gorczynski, Ariana Emory, Shawn Farrokhi Nov 2025

Evaluating The Effectiveness Of Clinical Practice Guideline Adherence For Patellofemoral Pain (Knee-Capp): Protocol For A Multisite, Parallel-Arm Randomized Clinical Trial In The Military Health System, Emma H. Beisheim-Ryan, Timothy C. Mauntel, Daniel I. Rhon, Charity G. Patterson, Nathan Parsons, Scott Paradise, Megan H. Roach, Marisa Pontillo, Sara R. Gorczynski, Ariana Emory, Shawn Farrokhi

Physical Therapy Faculty Articles and Research

Importance

Patellofemoral pain (PFP) frequently affects military personnel, caused by the physical demands of duty-related training. Clinical practice guidelines (CPG) can guide PFP management, yet physical therapist practice patterns vary and often exclude CPG-recommended, evidence-based interventions. Objective

The Evaluating the Effectiveness of Clinical practice guideline Adherence for Patellofemoral Pain (knEE-CAPP) trial assesses whether a CPG-adherent physical therapy approach more significantly reduces pain, disability, health care utilization, and analgesic medication prescription in Service members with PFP as compared to usual physical therapist care. Design

This is a multisite, parallel arm randomized controlled trial. Setting

The study will be conducted at 4 …


Newsletter, November 2025, Cedar Oaks Guild Nov 2025

Newsletter, November 2025, Cedar Oaks Guild

Cedar Oaks Guild Newsletter

No abstract provided.


Copyright Statement, Cleveland State Journal Of Law And Health Nov 2025

Copyright Statement, Cleveland State Journal Of Law And Health

Journal of Law and Health

No abstract provided.


Table Of Contents, Cleveland State Journal Of Law And Health Nov 2025

Table Of Contents, Cleveland State Journal Of Law And Health

Journal of Law and Health

No abstract provided.


Interventions To Enhance Care Partner Performance And Participation In Alzheimer's And Neurocognitive Disorders: A Systematized Review, Ainslie Suyko, Addison Werner, Elizabeth A. Stacy, Danielle M. Westmark, Stacy Smallfield, Molly A. Whitlow Nov 2025

Interventions To Enhance Care Partner Performance And Participation In Alzheimer's And Neurocognitive Disorders: A Systematized Review, Ainslie Suyko, Addison Werner, Elizabeth A. Stacy, Danielle M. Westmark, Stacy Smallfield, Molly A. Whitlow

Student Systematized Reviews: Occupational Therapy

Purpose: Care partners of people with Alzheimer’s disease (AD) and related neurocognitive disorders (NCDs) often experience disrupted routines, reduced self-care, and limited participation in meaningful occupations. Occupational therapy (OT) supports care partners’ engagement in health-promoting activities and sustainable caregiving (Rhodus et al., 2023). This systematized review examined interventions that enhance care partner performance and participation.

Design: Peer-reviewed, English-language articles were included if they involved adult care partners of individuals with AD or NCDs, implemented an intervention within the scope of OT, and used quantitate research designs.

Method: A total of 319 articles from MEDLINE, CINAHL, and Scopus were screened; 61 …


Interview No. 1807, Elidia (Lily) Jimarez Nov 2025

Interview No. 1807, Elidia (Lily) Jimarez

Combined Interviews

Elidia, or more commonly known as Lily, Jimarez was born and raised in Ciudad Juárez, Mexico. She grew up in an all-women household, with the exception of two brothers and her father. Her story begins when she was a little girl helping her mother in the kitchen, noticing the tools she used to make simple dishes such as beans and rice. My mother would steal ingredients in small portions and gather them in her makeshift kitchen, where all her pots and pans were also taken, never with the intention of returning them. She taught herself how to make certain foods …


Blackeyed Susan Establishment And Injury Following Application Of Common Roadsides Herbicides, Rachel C. Woody-Pumford, Matt Bertucci, Mike D. Richardson, Dirk Phillip, Hannah E. Wright-Smith Nov 2025

Blackeyed Susan Establishment And Injury Following Application Of Common Roadsides Herbicides, Rachel C. Woody-Pumford, Matt Bertucci, Mike D. Richardson, Dirk Phillip, Hannah E. Wright-Smith

Horticulture Faculty Publications and Presentations

Limited herbicide options are available for selective weed management in roadside native plantings. Thus, this field study evaluated blackeyed Susan's (Rudbeckia hirta L.) tolerance to four postemergence (POST) herbicides-quinclorac, florpyrauxifen-benzyl, clopyralid, and metsulfuron-during prairie establishment in Fayetteville, AR, across two growing seasons in 2022 and 2023. Blackeyed Susan was assessed for plant incidence, bloom count, and visible injury. In 2022, no reduction in blackeyed Susan blooms was detected in response to POST herbicides; however, peak bloom counts occurred 1 week after treatment (WAT) and ranged from 1.1 to 1.6 blooms per ft2. In 2023, at 10 WAT, blackeyed Susan plants …


Field Canals Improvement Projects Duration Prediction: A Comparative Analysis Of Machine Learning Models, Hania Ghouse, Ukaegbu Chinonso Ishmael, Edgar Dario Obando-Paredes, Hashem Shafik Shakir, Ali Al-Bayaty Nov 2025

Field Canals Improvement Projects Duration Prediction: A Comparative Analysis Of Machine Learning Models, Hania Ghouse, Ukaegbu Chinonso Ishmael, Edgar Dario Obando-Paredes, Hashem Shafik Shakir, Ali Al-Bayaty

Electrical and Computer Engineering Faculty Publications and Presentations

There are several essential elements in project construction management to be studied appropriately, and priority to these elements, such as cost and duration, is predominantly interesting to be investigated. In this research, the duration of field canal improvement projects (DFCIP) was predicted using two relatively new machine learning (ML) models - the Multivariate Adaptive Regression Spline (MARS) and Extreme Learning Machine (ELM). The targeted DFCIP was calculated using other dependent parameters, such as the length of the pipe, years of construction, the geographical zone of the network, the supplied area with water, and finally the actual cost of the field …


Interrelationships Among Social Media Use, University Social Capital, And Mental Health Outcomes In Undergraduate Students, Md Hasan Howlader Nov 2025

Interrelationships Among Social Media Use, University Social Capital, And Mental Health Outcomes In Undergraduate Students, Md Hasan Howlader

Lingnan Theses (MPhil & PhD)

Mental health concerns among university students have intensified globally, reflected in rising levels of psychological distress, declining life satisfaction, and reduced flourishing. These challenges present urgent implications for public health and higher education policy. Simultaneously, social media use (SMU) has become deeply embedded in students’ daily lives; however, its impact on mental health remains inconclusive. While some studies associate SMU with increased mental health issues, others emphasize its potential to foster social connection. These conflicting perspectives are further complicated by uncertainty regarding the directionality of these relationships—whether SMU influences mental health, or mental health status shapes SMU patterns. Furthermore, existing …


Book Review: Resisting The Dehumanization Of Refugees, Staci Martin Nov 2025

Book Review: Resisting The Dehumanization Of Refugees, Staci Martin

School of Social Work Faculty Publications and Presentations

Resisting the Dehumanization of Refugees, edited by Abu-Laban, Frishkopf, Hasmath, and Kirova, has a familiar quality when I read it. The book explores the profound struggle to cocreate a sense of home and belonging amidst the relentless dehumanization refugees face from restrictive policies, biased media portrayals, and societal prejudice. It adopts a transdisciplinary approach, featuring contributions from scholars, practitioners, and refugees themselves, who focus on the Canadian context and draw on broader international comparisons that support both the mechanisms of dehumanization and strategies for resistance.


Michael D. Shaw, Sr. Nov 2025

Michael D. Shaw, Sr.

African American Funeral Programs

No abstract provided.


Multidomain Therapy For Alzheimer's Disease: A Scoping Review Of Cognitive Decline Trials, Jared C Roach, Cyrus A Raji, Et Al. Nov 2025

Multidomain Therapy For Alzheimer's Disease: A Scoping Review Of Cognitive Decline Trials, Jared C Roach, Cyrus A Raji, Et Al.

2020-Current year OA Pubs

BACKGROUND: Alzheimer’s disease (AD) leading to cognitive decline and dementia results from the interplay of multiple interacting dysfunctional biological systems. These systems can be categorized by domain, such as inflammation, cardiovascular health, proteostasis, or metabolism. Specific causes of AD differ between individuals, but each individual is likely to have causes stemming from multiple domains. Personalized multidomain therapy has been proposed as a standard of care for AD. OBJECTIVES: We sought to enumerate and describe prospective randomized controlled trials (RCTs) for multidomain interventions for AD, and to extract their inclusion criteria, trial design parameters (length, number of participants), and outcome measures. …


Traumatic Fracture Of Kager's Fat Pad: A Case Report., Victoria Di Castro Horn, Margaret Hurley, Emily Andrews, Alberto Giardini Nov 2025

Traumatic Fracture Of Kager's Fat Pad: A Case Report., Victoria Di Castro Horn, Margaret Hurley, Emily Andrews, Alberto Giardini

PCOM Scholarly Works

BACKGROUND: Kager's fat pad is a metabolically active adipose structure within Kager's triangle anterior to the Achilles tendon, involved in shock absorption, vascular support, and tendon lubrication. Although most research has focused on its role in Achilles tendinopathy and inflammatory conditions, isolated traumatic disruption without concurrent tendon damage has been rarely documented in the literature, to our knowledge. We report a case of an isolated traumatic fracture of the Kager's fat pad in the absence of concomitant Achilles tendon injury.

CASE PRESENTATION: An otherwise healthy 31 year-old female presented to the outpatient musculoskeletal office with reported pain at the distal …


The Differential Effects Of Camp Mobilizing Agents On Tgf-Β-Induced Extracellular Matrix In Human Lung-Derived Fibroblasts: Insights Into Therapeutic Targets For Lung Fibrosis, Sarah Orfanos, Brian T. Deeney, Gaoyuan Cao, Nikhil Karmacharya, Anjani Ravi, Cynthia J. Koziol-White, Qi Yang, Rennolds S. Ostrom, Reynold A. Panettieri Jr. Nov 2025

The Differential Effects Of Camp Mobilizing Agents On Tgf-Β-Induced Extracellular Matrix In Human Lung-Derived Fibroblasts: Insights Into Therapeutic Targets For Lung Fibrosis, Sarah Orfanos, Brian T. Deeney, Gaoyuan Cao, Nikhil Karmacharya, Anjani Ravi, Cynthia J. Koziol-White, Qi Yang, Rennolds S. Ostrom, Reynold A. Panettieri Jr.

Pharmacy Faculty Articles and Research

Background

Injury-repair responses typically induce tissue or organ scarring. Generally, cAMP-mobilizing agents inhibit the activation of fibroblasts and deposition of extracellular matrix. Some but not all cAMP-mobilizing agents inhibit fibrosis. Evidence suggests that inhaled treprostinil, a prostacyclin (IP) analog, increases intracellular cAMP levels [cAMP]I, and slows the decline in pulmonary function in patients with idiopathic pulmonary fibrosis (IPF). However, the molecular mechanisms by which cAMP-mobilizing agents, including treprostinil, alter the expression of matrix proteins in human lung fibroblasts (HLF) remain unclear. Unlike other Gαs -coupled receptors, we posit that the antifibrotic properties of treprostinil are driven by cAMP-mobilizing-dependent and -independent …


An Experiential Learning Lab Activity On Skeletal Muscle Physiology In Undergraduate Md Pre-Clerkship Curriculum, Angela Martinez, Daniel Salinas, Meyer Maddox, Kelsey A. Potter-Baker, Amin Shah Nov 2025

An Experiential Learning Lab Activity On Skeletal Muscle Physiology In Undergraduate Md Pre-Clerkship Curriculum, Angela Martinez, Daniel Salinas, Meyer Maddox, Kelsey A. Potter-Baker, Amin Shah

School of Medicine Publications

Experiential learning is an important part of the medical education curriculum. Due to clinical relevance of skeletal muscle strength in evaluating patients’ complaints of muscle weakness or imbalance, skeletal muscle physiology is an important concept with extensive potential for experiential learning opportunities. Our goal was to establish an experiential learning skeletal muscle physiology lab activity that would improve undergraduate MD pre-clerkship students’ skill to collect muscle force measurements using a hand-held dynamometer (HHD) and expand knowledge of core physiological concepts. We developed a muscle lab activity where students performed two experiments using an HHD: (1) The Elbow Flexion Experiment and …


Harnessing Hyperspectral Imaging And Deep Learning For Terrestrial Habitat Mapping In Arid Landscapes: A Case Study In Saudi Arabia, Ali Elgendy, Hesham Morgan, Brandon Tran, Rejoice Thomas, Tamer Ismail, Yehya Kh. Shehadeh, Ahmed Elgharib, Ahmed Abdullah Al-Dughairi, Ali El Muburak, Khaled Allam Harhash, Hesham El-Askary Nov 2025

Harnessing Hyperspectral Imaging And Deep Learning For Terrestrial Habitat Mapping In Arid Landscapes: A Case Study In Saudi Arabia, Ali Elgendy, Hesham Morgan, Brandon Tran, Rejoice Thomas, Tamer Ismail, Yehya Kh. Shehadeh, Ahmed Elgharib, Ahmed Abdullah Al-Dughairi, Ali El Muburak, Khaled Allam Harhash, Hesham El-Askary

Mathematics, Physics, and Computer Science Faculty Articles and Research

Arid ecosystems remain under-mapped at actionable scales despite their ecological importance. Decision makers lack reliable, high-resolution habitat maps in drylands to prioritize protection and target restoration. This research integrates spaceborne hyperspectral imaging from the Environmental Mapping and Analysis Program (EnMAP) with deep learning semantic segmentation models to produce an updated level of habitat classification based on the International Union for Conservation of Nature (IUCN) for part of the Imam Turki bin Abdullah Royal Reserve, Saudi Arabia. Using ground control points and the full EnMAP spectral cube without band selection, U-Net and DeepLabV3+ architectures were each implemented with VGG19 and ResNet-101 …


Divergent Prefrontal Cortex Circuits Regulate Cued Food Seeking Under Distinct Metabolic Or Emotional States, Xu O Zhang, Guillermo Aquino-Miranda, Claire E Cho, Yongzhe Wang, Duy Hoang Ha, Allen Dong, Fabricio H Do-Monte Nov 2025

Divergent Prefrontal Cortex Circuits Regulate Cued Food Seeking Under Distinct Metabolic Or Emotional States, Xu O Zhang, Guillermo Aquino-Miranda, Claire E Cho, Yongzhe Wang, Duy Hoang Ha, Allen Dong, Fabricio H Do-Monte

Faculty, Staff and Student Publications

Flexibly adjusting food-seeking behaviour in response to food-associated cues and internal states is crucial for animals' survival. However, the neural mechanisms that modulate cued food-seeking behaviour during varying metabolic (i.e., hungry vs. satiated) and emotional (i.e., safe vs. threatened) states remain elusive. Here, we show that the encoding of metabolic or threat states in projection-defined neurons in the prelimbic cortex (PL) mediates cued food-seeking responses in rats. Using microendoscopic imaging, we demonstrate that neural population dynamics in PL consistently represent food cues, task-relevant behaviours, and internal state changes by recruiting distinct subsets of cue-responsive neurons at each state. Single-unit recording …


Retraction Note: Runt-Related Transcription Factor 1 Promotes Apoptosis And Inhibits Neuroblastoma Progression In Vitro And In Vivo, Yuanyuan Chu, Jiarui Pu, Qiangsong Tong, Harish C Joshi, Shaotao Tang, Shiwang Li Nov 2025

Retraction Note: Runt-Related Transcription Factor 1 Promotes Apoptosis And Inhibits Neuroblastoma Progression In Vitro And In Vivo, Yuanyuan Chu, Jiarui Pu, Qiangsong Tong, Harish C Joshi, Shaotao Tang, Shiwang Li

Faculty, Staff and Students Publications

No abstract provided.


Gboost-Ctl: A Novel Method In Multi-Tissue Transcriptome-Wide Associations Studies In Cross-Tissue Learner Incorporating Gwas Information, Md Mutasim Billah, Hairong Wei, Fengzhu Sun, Kui Zhang Nov 2025

Gboost-Ctl: A Novel Method In Multi-Tissue Transcriptome-Wide Associations Studies In Cross-Tissue Learner Incorporating Gwas Information, Md Mutasim Billah, Hairong Wei, Fengzhu Sun, Kui Zhang

Michigan Tech Publications

Genome-wide association studies (GWAS) have uncovered numerous genetic variants linked to complex human diseases, yet linking these variants to transcripts and tissues that drive pathology remains difficult. Multi-tissue transcriptome-wide association studies (TWAS) offer a powerful bridge, but existing analytical methods have some limitations, either by discarding important signals by separately analyzing and then aggregating results across tissues, implying imputation models in individual tissues, or fusing them with weights that ignore how much GWAS signal each tissue actually carries. Therefore, most of the existing methods do not work uniformly across different GWAS cohorts. Here, we propose GBoost-CTL - a GWAS-boosted cross-tissue …


Analysis And Interpretation Of Somatic Nmd-Escaping Variants In Oncogenes And Dual-Function Genes Across Adult And Pediatric Cancer Cohorts, Runjun D Kumar, Jiaming Li, Mark R Wilkinson, Lu Wang, Jeffery M Klco, Li Tang, Jennifer L Neary, Sharon E Plon, Patrick R Blackburn Nov 2025

Analysis And Interpretation Of Somatic Nmd-Escaping Variants In Oncogenes And Dual-Function Genes Across Adult And Pediatric Cancer Cohorts, Runjun D Kumar, Jiaming Li, Mark R Wilkinson, Lu Wang, Jeffery M Klco, Li Tang, Jennifer L Neary, Sharon E Plon, Patrick R Blackburn

Faculty, Staff and Students Publications

Interpreting protein-truncating variants predicted to escape nonsense-mediated decay (NMDe) based on the 50-bp rule is challenging due to their variable consequences. The Clinical Genome Resource, Cancer Genomics Consortium, and Variant Interpretation for Cancer Consortium recommendations focus on tumor suppressor genes where NMDe variants may result in loss-of-function. However, guidance for interpreting NMDe variants in oncogenes and dual-function genes remains limited. To address this gap, we screened the Catalogue of Somatic Mutations in Cancer, focusing on oncogenes and dual-function genes with ≥10 NMDe variants supported by published functional studies. This analysis prioritized 15 genes exhibiting two distinct NMDe patterns resulting in …


Bilateral Concomitant Infection Of Cytomegalovirus And Varicella-Zoster Virus Retinitis In An Immunocompromised Adult, Nhon Le, Asad Loya, Tahira Scholle Nov 2025

Bilateral Concomitant Infection Of Cytomegalovirus And Varicella-Zoster Virus Retinitis In An Immunocompromised Adult, Nhon Le, Asad Loya, Tahira Scholle

Faculty, Staff and Students Publications

Purpose: To report a novel case of bilateral concomitant cytomegalovirus (CMV) retinitis and acute retinal necrosis (ARN) due to varicella-zoster virus (VZV) in an immunocompromised adult.

Methods: A case report was evaluated.

Results: A 36-year-old immunocompromised man presented with acute painful vision loss in the left eye. On initial presentation, uncorrected distance visual acuity was 20/20 in the right eye and counting fingers at 3 feet (≈1 m), which deteriorated to no light perception (NLP) in the left eye. Fundus examination showed necrotizing retinitis in both eyes, with features of both CMV retinitis and ARN. One week after initiation of …


Rrad-Reduction Reveals Efficacy Of Targeting L-Type Calcium Channel Regulation For Treatment Of Heart Failure, Garrett Elmore, Sarisha S Lohano, Nicholas M Mcvay, Bryana M Levitan, Andrea Sebastian, Kyle W Barker, Alec Dupont, Steven W Leung, Riham R E Abouleisa, Pretty R Mathew, Austin Wellette-Hunsucker, Austin T Minton, Kenneth S Campbell, Solomon W Harrar, Mohammad Mehri, Jonathan F Wenk, Tamer M A Mohamed, Douglas A Andres, Jonathan Satin Nov 2025

Rrad-Reduction Reveals Efficacy Of Targeting L-Type Calcium Channel Regulation For Treatment Of Heart Failure, Garrett Elmore, Sarisha S Lohano, Nicholas M Mcvay, Bryana M Levitan, Andrea Sebastian, Kyle W Barker, Alec Dupont, Steven W Leung, Riham R E Abouleisa, Pretty R Mathew, Austin Wellette-Hunsucker, Austin T Minton, Kenneth S Campbell, Solomon W Harrar, Mohammad Mehri, Jonathan F Wenk, Tamer M A Mohamed, Douglas A Andres, Jonathan Satin

Faculty, Staff and Students Publications

Aims: Heart failure with reduced ejection fraction (HFrEF) is a major health problem. Increasing L-type calcium channel (LTCC) activity deteriorates heart function; however, myocardial RRAD knockout (cRADΔ/Δ) instills tonic modulated LTCC current (ICa,L) that preserves healthy myocardium. Thus, we chose to challenge the dogma that enhanced trigger Ca2+ is maladaptive. The study objective was to test the hypothesis that modulated ICa,L in cRADΔ/Δ mice rescues dilated cardiomyopathy by providing tonic modulated trigger Ca2+.

Methods and results: Mouse and human models were tested. The muscle lim protein knockout mouse (MLPKO) is a murine model of dilated cardiomyopathy (DCM) and HFrEF. The …