Digital Commons Network^™

Synthetic Lectins, A Diagnostic And Prognostic Tool For Detecting Glycans In Breast Cancer, Daniel James Gordon

Theses and Dissertations

Cancer diagnostic tools have been pushed to the forefront of medical research because a person’s chance of survival is directly correlated with how early the tumor is identified and treatment is begun. In searching for the subtle differences between healthy and tumor cells, almost every type of cancer has been shown to under, over, or neo express glycans, and these changes in the glycan fingerprint can continue as the disease progresses. This provides a powerful diagnostic opportunity that’s works by screening for glycoproteins and glycosylation patterns that deviate from normal cells.

Boronic acids have a useful and tunable property in …

Instrumental Gendering: A Case Study Of Convent Bajón Tradition In Early Modern Spain, Taylor Danielle Gable

Theses and Dissertations

It is generally accepted by Western music epistemologies that women did not perform on wind instruments during the early modern era. Recent organological and convent research has discovered a female bajón tradition in Spanish convents. This tradition lasted from the mid-15th century through the early 20th century. This document discusses the implications of this tradition and explores why similar traditions did not exist throughout early modern Europe. Capitalism, church law, and early modern medical theories are all discussed to give a fuller context of gender and music performance in the early modern era.

The Relationship Between Mindset And Motivation In An Alternative School Mathematics Classroom, Jo Ellen Dowdy

Theses and Dissertations

The purpose of this action research study was to determine the impact of a Khan Academy growth mindset lesson plan on the motivation of at-risk ninth grade students in a mathematics classroom. Data were collected for quantitative analysis of students’ self- reporting of perceptions pertaining to mindset beliefs before and after a mindset intervention and perceptions about motivation in the mathematics classroom. Analysis revealed there was no relationship between mindset and motivation. A minimal decrease in fixed mathematical mindset was determined after a Khan Academy mindset intervention. Increases were found in students’ beliefs in the importance of math, the usefulness …

The Impact Of Individualized Structured Reading Intervention On High School Students In Special Education: An Action Research Study, Nikki Clark

Theses and Dissertations

Reading skills comprise the following three categories: decoding, fluency, and comprehension. All three of these skills are necessary for students to become successful readers in and out of academic settings. Many students in special education read far below their grade level; difficulty reading is particularly challenging for such students because, in addition to limiting academic success, under-developed reading skills compromise students’ academic and functional independence. This study aimed to examine how a structured, individualized reading intervention may help high school students in special education – students who have been diagnosed with one specific disability or a combination of approved disabilities …

Lady Alhambra, Gabriela Castillo

Theses and Dissertations

In this thesis I make a retrospective analysis of the creative process through which I conceived my original solo performance piece, Lady Alhambra: a 15-minute one-person comedy that tells the story of Nila, a Cuban-American vedette and autodidactic spiritualist working at a cabaret called the House of Mambo. I define my creative process in three stages, each classified and described in chapters one through three. Chapter one describes the initial stage of exploration. Chapter two describes the intermediate stage of evolution. Then chapter three describes the final stage which is the performance. Lastly, I contemplate on the future of …

Examining Caregiver Vigilance For Child Sexual Abuse, Kate K. Chappell

Theses and Dissertations

Child sexual abuse (CSA) affects approximately one in four US children through adolescence. As an adverse childhood experience (ACE) implicated in long-term health and wellbeing, CSA is a pervasive safety concern. The influence of caregivers and healthcare providers is under-realized in CSA prevention. Examining the thinking processes preceding CSA vigilance response has been limited in research. Understanding the complexities in healthcare related to addressing CSA will facilitate caregiver-focused intervention in primary care. Guided by social ecology and protection motivation theories (PMT), the goals of this two-phase study were to explore caregiver cognitive processes towards vigilance for CSA and the challenges …

The Distribution Of [ʍ]: An Acoustic Analysis Of Sociophonetic Factors Governing The Wine-Whine Merger In Southern American English, Keiko Bridwell

Theses and Dissertations

In US English, the merging of the voiceless labiovelar glide [ʍ] and its voiced counterpart [w] has been an ongoing process over the past century, originating in central port cities on the Atlantic seaboard and gradually spreading to include the bulk of the continental US. While described by many sources as still present in Southern American English, the so-called wine-whine merger shows evidence of nearing its completion as its usage becomes increasingly rare even within the Southeast, even as the segment [ʍ] is interpreted as a feature of Southern speech. Despite this fact, very little research has been conducted on …

Heterogeneous Catalysis For The Upgrading Of Biomass Derived Chemicals Via Hydrodeoxygenation, Elizabeth Barrow

Theses and Dissertations

An important step in the upgrading of biomass derived chemicals is the removal of excess oxygen. The works reported here are focused on studying the heterogeneous catalysts that can be utilized for that upgrading through hydrodeoxygenation. This work begins with a discussion of the alkylation of short chain platform chemicals for chain growth and also demonstrates the proof of concept of combining alkylation and hydrodeoxygenation in a single step. Then, because of the promising nature of ReOx- Pd/CeO2 for selective hydrodeoxygenation, a detailed study of ReOx/CeO2 is presented. Finally, a new surface structure interpretation is presented for P/Ni(111) which could …

Surface Science And Engineering Of Nano-Structured Cathodes For Intermediate Temperature Solid Oxide Fuel Cells, Yeting Wen

Theses and Dissertations

The bulk-to-surface Sr-segregation can seriously compromise the stability of oxygen electrocatalysis in Sr-doped perovskite oxides such as La1-xSrxCoO3-δ and La1-xSrxCo1- yFeyO3-δ and limit their practical applications as cathode materials in solid oxide fuel cells. Although such chemical instability has been actively studied in recent years, fundamental understanding of Sr-segregation process vs temperature and time, particularly under real-world conditions, as well as the suppression method, are still needed. This PhD dissertation aims to acquire fundamental knowledge of Sr-segregation process under practical conditions in solid oxide fuel cells and develop suppression method to ensure the long-term stability through surface modifications.

To gain …

Constrained Consensus In Continuous-Time Multi-Agent Systems, Zheqing Zhou

Theses and Dissertations

Since the consensus problem is getting popular in recent researches and the applications based on it are expanding in current years! the consensus problem under the condition that constraints exist on agents’ state in continuous-time in a multi-agent system has been studied here. This work combines the projection operator method in a general consensus algorithm to avoid the violation of state on its individual constraint set. When the projection operator works in the general consensus algorithm, the constraint region is divided into the projection-operator working region and the non-projection region. The boundary between these two regions is a circular line. …

An Instruction Embedding Model For Binary Code Analysis, Kimberly Michelle Redmond

Theses and Dissertations

Binary code analysis is important for understanding programs without access to the original source code, which is common with proprietary software. Analyzing binaries can be challenging given their high variability: due to growth in tech manufactur- ers, source code is now frequently compiled for multiple instruction set architectures (ISAs); however, there is no formal dictionary that translates between their assem- bly languages. The difficulty of analysis is further compounded by different compiler optimizations and obfuscated malware signatures. Such minutiae means that some vulnerabilities may only be detectable on a fine-grained level. Recent strides in ma- chine learning—particularly in Natural Language …

Associations Among Parenting Style And Parental Feeding Practices On Adolescent Self-Efficacy For Diet And Obesity In African American Adolescents, Haylee Loncar

Theses and Dissertations

Previous literature has demonstrated relationships between parenting factors and child health. However, few studies have investigated such associations in African American and adolescent samples. The proposed study aimed to investigate the relationships between parenting factors (parenting style and parental feeding practices), and adolescent self-efficacy for diet, and adolescent body mass index (BMI) in African American families. Baseline data were collected from 241 African American parent- adolescent dyads enrolled in the Families Improving Together (FIT) for Weight Loss trial. Adolescents self-reported their perceptions of their caregiver’s parenting style and feeding practices, as well as perceptions of their own self-efficacy for diet. …

The Impact Of Readers Theater On Fluency, Emily Suggs

Theses and Dissertations

This action research study describes a problem of practice derived from the identification of students in fifth-grade who lack reading skills to be classified fluent readers as identified by Dynamic Indicators of Basic Early Literacy Skills-Next Edition Oral Reading Fluency (DIBELS Next ORF). This problem of practice led to the development of an action research study, which examined the impact of fluency instruction that used readers theater texts on students’ overall fluency performance.

Through a convergent mixed methods design, the study addressed three research questions that explored the impact of using readers theater texts on students’ overall fluency performance, the …

Codification Of Terminology And Procedure In Mental Practice With Applications To Piano Pedagogy, Anna Beth Rucker

Theses and Dissertations

Mental practice has been discussed among piano pedagogues from the nineteenth century until the present. Over time, many terms have been used to describe different kinds of mental practice. This variety can make it challenging for the independent teacher to consolidate the information and effectively apply mental practice to the private lesson. For this reason, a codification of the terms associated with mental practice is presented in this thesis. Terms are classified into four groups: Visualization (kinesthetic imagery and musical imagery), Aural (aural imagery and audiation), Psychological (mental wellness and guided imagery), and Hybrid (practice away from the piano and …

Structural And Functional Studies On 4-Hydroxy- Tetrahydrodipicolinate Reductase: Potential Drug Target In Bacteria, Swanandi Pote

Theses and Dissertations

Antimicrobial resistance has become an alarming public health concern since early 2000’s. Infections caused by multidrug resistant bacteria not only increase the mortality rate but also increase the economic burden globally. One approach to alleviate this issue is to find novel drug targets. In this regard, the bacterial lysine biosynthesis pathway provides several targets that may be used for design of antimicrobial compounds. Bacteria use lysine or meso-diaminopimelate to crosslink the peptidoglycan monomers in the bacterial cell wall. As such, we hypothesize that blocking this pathway will induce defects in the bacterial cell wall that are similar to those …

A Conceptual Mapping Approach For Presenting A Practical Past: Addressing Responsibility Through Contextualization In Information System Design For The Ward One Mobile Application, Sadia Obaid Khan

Theses and Dissertations

This paper presents and documents a model for telling history through technology using the Ward One application for iOS mobile devices as a test site for the idea of conceptual mapping. The historical-information delivery system was created to mobilize the rhetoricity of representation that is a procedural necessity of technological mediation.

The paper begins by explaining the exigence of the app—to tell the history of an African-American community displaced from the land now occupied by the University of South Carolina as a result of racially discriminating housing policies in Columbia, SC and across the United States. It then addresses the …

Mle And Bayesian Methods To Analyze Data With Missing Values Below The Limit Of Detection, Xinxin Hu

Theses and Dissertations

As pesticides are widely used in agriculture, more and more people who work at places like farm are exposed to the pesticides. According to enviroment re- searches [Villarejo; 2003; Reigart and Roberts; 1999], being exposed to some kind of pesticides like Organophosphorus (OP) insecticides has significantly effected the health of farmworkers and their family. The actual level of pesticides can be detected with some limitation for now. However, it is hard to detect when the level is below the limit of detection (LOD). Therefore, the goal of our research is to propose several different methods to analyze data …

Made To Be Forgotten: The Chevalier De Saint-Sauveur & The Franco-American Alliance, Katelynn Hatton

Theses and Dissertations

In 1778, during the early days of the Franco-American alliance, a Boston mob killed the Chevalier de Saint-Sauveur, a high-ranking French officer, jeopardizing the two countries’ partnership just as soon as it began. American and French leadership alike quickly went to work in transforming the story of Saint-Sauveur’s death from one of anti- Catholic sentiment into one that demonstrated the urgency for unity and cohesion. Through the promise of a monument, his death became a teachable moment, signifying the fragility of the alliance and the importance of cooperation on both martial and civic levels.

By the time of the Great …

Convertirse En Inmortal, 成仙 Chéngxiān, Becoming Xian: Memory And Subjectivity In Cristina Rivera Garza’S Verde Shanghai, Katherine Paulette Elizabeth Crouch

Theses and Dissertations

Verde Shanghai, published in 2011 by Cristina Rivera Garza, is often used in discussions of Orientalism in Latina America and Mexico. The text employs tropes and stereotypes common in Orientalist thinking, but to label the work Orientalist and analyze it through that lens seems too simplistic. I argue that Verde Shanghai ultimately proves a refutation of Orientalism’s existence within Mexico, and, more broadly, an overall deconstruction of the East-West dichotomy. Rivera Garza appears more interested in using racial and cultural identities to dismantle the polar dichotomies in which her characters live, ultimately critiquing these frameworks in the outside world.

Nutrient Limitation Of Phytoplankton In Lake Wateree, South Carolina: Implications For Future Water Quality Management, Kara M. Clyburn

Theses and Dissertations

Cultural eutrophication is a primary contributor to phytoplankton production in freshwater lakes from excess anthropogenic nutrient inputs, and resulting impacts on water quality, aquatic ecosystems, human and animal health are increasing worldwide. Understanding the factors that limit phytoplankton growth is an important strategy for identifying and managing nutrient sources and successfully controlling the over- enrichment of nitrogen (N) and/or phosphorus (P) in freshwater lakes. The Redfield molecular ratio of carbon (C), N and P maintains that the C:N:P molar ratio is 106:16:1 when nutrients are not limiting, and the ecosystem is balanced. A N:P molar ratio > 20:1 tends to be …

Assessing Readiness For A Physical Activity Intervention In Positive Youth Development Afterschool Programs, Brittany Skiles Cook

Theses and Dissertations

Physical inactivity has been identified as a primary health threat to youth, and existing afterschool programs (ASP) are a promising context for implementing physical activity (PA) interventions. However, few PA interventions have been effective and generalizability of programs has been poor. Assessing organizational readiness during the testing of a PA intervention can help inform generalizability and sustainability. The R=MC2 heuristic separates readiness into motivation, innovation-specific capacity, and general capacity, each of which are further divided into subcomponents. The current multiple-case study pilot tests the feasibility and effectiveness/efficacy of a readiness assessment tool based on R=MC2 developed for the Connect through …

A Site Characterization And Assessment Of The Bushy Park Reservoir, A Charleston-Area Drinking Water Source, And Its Surrounding Watersheds In Response To Community Concerns, Bradley Joseph Chandler

Theses and Dissertations

Access to clean, safe drinking water is considered a basic human right (WHO 2004). It is vital to maintain adequate monitoring of source waters as well as to investigate claims of degraded source waters. In June of 2017, inaccurate reporting led many community members in Mt. Pleasant, SC to believe that their drinking water might be tainted, leading to elevated cases of brain cancer in children. Though steps were taken to test and ensure the drinking water was safe, fear over the health of the city’s drinking water still persists. This is largely due to the involvement of famed water …

Studying The Voice Of Mo Yan And Howard Goldblatt: Zhang Kou In The Garlic Ballads, Yiran Yang

Theses and Dissertations

In 2012, a Chinese, Mo Yan 莫言, became the laureate of the Nobel Prize in Literature. It was the first time in China’s history; this is not because Mo Yan is better than other Chinese writers, or that he follows some Western writers like Gabriel García Márquez, but because he works with better translators, who make his stories captivating for Western readers, than whom his precursors work with. Even though Mo Yan sticks closely to dialect and culture in rural areas in northern China, his translators adjust his writings to an accessible form in another language. In order to understand …

Water Systematics Of Samoan Peridotite Xenoliths, Aaron Wolfgang Ashley

Theses and Dissertations

Water influences geodynamic processes such as melting, deformation and rheology. Yet its distribution in the oceanic upper mantle is primarily known indirectly from melt inclusions and glasses of erupted mantle melts (i.e. MORB and OIB). To constrain the mechanisms influencing the distribution of water in the mantle, we analyzed 15 peridotite xenoliths from Savaiʻi and 2 dunite xenoliths from Taʻū (Samoa) for water concentrations (by polarized FTIR) and major/trace elements. Savaiʻi peridotites are among the most melt depleted oceanic xenoliths recovered (degrees of melt depletion ≥15%). They show strong evidence of transient metasomatism by both carbonatite and silicate melts, with …

“Hiv Lives With Me”: An Intersectional Analysis Of The Successful Navigation Of Health Care Services By Sex Workers Living With Hiv, Kierra Jones

Theses and Dissertations

Sex workers living with HIV are affected by pervasive stigma across various life domains because they are situated between two stigmatized identities—their HIV status and as someone who exchanges sexual services for pay. Prior research suggests that not only can stigma hinder attempts to initially access health care services, but it can also foster strained and unwelcoming environments. The purpose of the present study is to illuminate the voices and experiences of sex workers living with HIV as they navigate their specific health care needs. Using an intersectional lens, the aim of this study is to understand the health care …

The Role Of Historical Simulations In An International Baccalaureate Primary Years Program Social Studies Class, Anna Hasenkamp

Theses and Dissertations

This paper presents an action research study as part of a Dissertation in Practice. Based on observations from the classroom of the participant-researcher, Problem of Practice is described: an over-reliance on teacher-centered instructional methods and the mismatch of these instructional techniques to the pedagogy endorsed by the International Baccalaureate. Through the identification of this PoP led to a research focus concerning student achievement, instructional methods, and the use of historical simulations in the social studies classroom. As a result of this research focus, the research question of what, if any, is the possible impact of historical simulations on student achievement? …

The Impact Of Student-Centered Coaching On The Implementation Of Project-Based Learning: An Action Research Study, Wanda Nicole Littlejohn

Theses and Dissertations

The present study describes a student-centered in-service that was implemented with four new teachers. The purpose of the study was to determine the level of confidence the four teachers felt after the coaching sessions. The study took place with teachers who teach in a high poverty school located in Greenville, South Carolina. The teacher-researcher is an Instructional Specialist at the school and she designed a project- based (PBL) learning unit with the teachers for ninth-grade students that was used in the coaching sessions in the fall of 2018. Data sources include: focus group interviews with the teachers; observations in the …

Brca1 And Brca2 Mutation Carrier Perspectives On Direct-To- Consumer Genetic Testing For Brca Mutations, Caitlyn E. Mitchell

Theses and Dissertations

Recently the FDA authorized one direct-to-consumer genetic testing (DTC-GT) company to begin reporting certain genetic variants in the BRCA1 and BRCA2 genes. Pathogenic variants in these genes confer lifetime risks for breast and ovarian cancer in women as high as 87% and 62%, respectively. Historically, genetic testing for these mutations has been offered in a clinical setting where genetic counseling is part of the testing process. Genetic counseling is not routinely a part of DTC-GT, raising concern that those undergoing DTC-GT for BRCA1/2 mutations may not fully understand what is being tested, the implications of results, or that they may …

Managing Negative Countertransference Utilizing An Integrated Counselor Mindfulness Training For Counselors Working With Children Exhibiting Externalized Behaviors, Jessie D. Guest

Theses and Dissertations

Using a multiple-probe, single case research design, this study investigated the effects of an integrated mindfulness intervention on counselors’ negative countertransference while working with children exhibiting externalized behaviors in session. More specifically, this study utilized a two-pronged intervention including mindfulness practices as well as the theoretical tenets of relating to children to assist counselors in managing negative countertransference as measured by the Countertransference Management Scale (Perez- Rojas, et al., 2017), reducing negative countertransference feelings as measured by Therapist Appraisal Questionnaire (Cooley & Klingler, 1989; Fauth et al., 1999), and improving the child’s perception of the counselor as measured by Young …

Development Of Nickel Catalyzed Cross-Coupling Methodologies, Ryan J. Key

Theses and Dissertations

In this work, we have addressed some of the issues surrounding catalytic crosscoupling reactions by using a nickel terpyridine catalyst, [Ni(tpy)(py)(CH3CN)2](PF6)2 in the Buchwald-Hartwig amination reaction and a functionalized variant, [(2,2':6',2''- terpyridine-4'-benzoic acid)Ni(II)]Cl2 on SiO2, in Suzuki coupling. These processes are unique in the approaches taken to achieve reactivity. In the Buchwald-Hartwig amination reaction, we used photoredox dual catalytic methods to achieve a sustainable approach to generate secondary and tertiary amines. This report is unique in many ways; most importantly, this method uses N-centered radicals to generate new C-N bonds. This report is also the first report to show generation …