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Transduced Autologous Cells: New Perspective For Delivery Of Biologics, Sushil Yadaorao Raut, Avinash Gahane Mar 2019

Transduced Autologous Cells: New Perspective For Delivery Of Biologics, Sushil Yadaorao Raut, Avinash Gahane

Manipal Journal of Pharmaceutical Sciences

No abstract provided.


Аpplication Of Minimally Invasive Endovascular Methods Of Treatment In Patients With Diabetic Gangraine Of The Lower Extremities, B.D. Babadjanov Mar 2019

Аpplication Of Minimally Invasive Endovascular Methods Of Treatment In Patients With Diabetic Gangraine Of The Lower Extremities, B.D. Babadjanov

Central Asian Journal of Medicine

Aim: to study the effectiveness of minimally invasive endovascular methods in the treatment of diabetic gangrene of the lower extremities, depending on the risk of loss of the limb. Material and methods: the results of the study and inpatient treatment of 323 patients for 2012-2018 were analyzed. with surgical complications of DFS in the Republican center of purulent surgery and surgical complications of diabetes at the 2nd clinic of the Tashkent Medical Academy. All patients suffered from type 2 diabetes. In 63% of cases (203), patients received insulin for the correction of blood sugar. Among male patients, there were 225 …


The Role Of Gene Polymorphism Of Neurohumoral Factors In The Development Of Chronic Heart Failure, A.G. Gadayev Mar 2019

The Role Of Gene Polymorphism Of Neurohumoral Factors In The Development Of Chronic Heart Failure, A.G. Gadayev

Central Asian Journal of Medicine

The authors highlighted the latest modern information on the selection of complex genes at the occurrence of various phenotypes of CHF. The article emphasizes that the selection of optimal group for the recommended drugs, based on the participation of candidate genes in the pathogenesis of the disease, plays an important role in ensuring the effective prevention and prevention of adverse effects of the disease.


Evaluation Of Quality Of Life Of Patients With Liver Cirrosis After Portosystemic Shunting Depending On Compliance Of Postoperative Recommendations, F.G. Nazirov Mar 2019

Evaluation Of Quality Of Life Of Patients With Liver Cirrosis After Portosystemic Shunting Depending On Compliance Of Postoperative Recommendations, F.G. Nazirov

Central Asian Journal of Medicine

The article is devoted to the assessment of the quality of life of patients with cirrhosis of the liver after portosystemic shunting. To assess the quality of life, a special questionnaire was used for patients with chronic liver diseases - The Chronic Liver Disease Questionnaire. Also in our study we applied visual analogue scales. The analysis of the quality of life was performed in 490 patients with cirrhosis of the liver after portosystemic shunting. Of the total sample of patients analyzed in our work, the proportion of follow-up results was 78.6% (385 patients). Taking into account the main pathology, both …


Studying Behavioral Strategies In Patients With Multidrug-Resistant Lung Tuberculosis And Low Treatment Adherence, М.Kh. Jurabayeva Mar 2019

Studying Behavioral Strategies In Patients With Multidrug-Resistant Lung Tuberculosis And Low Treatment Adherence, М.Kh. Jurabayeva

Central Asian Journal of Medicine

Tuberculosis, as a severe somatic disease, is often accompanied by certain neuro-psychiatric disorders. The difficulty in contact of patients in communication, leading to a violation of the behavior and its adaptive systems are observed. The article describes the results of studying the emotional, motivational and cognitive components of the relationship to the disease in patients with drug-resistant pulmonary tuberculosis and attempts to identify possible causes of low adherence to treatment. In this work, modern methods were used (the eight-color Luscher questionnaire, a diagnostic technique for the type of attitude towards the disease, etc.), mandatory keeping of a mood diary is …


The Results Of Surgical Treatment Of Patients With Acute Knee Injury In The Near Аnd Long-Term Period Through The Introduction Of Tactics Of Early Arthroscopy., M.Yu. Karimov Mar 2019

The Results Of Surgical Treatment Of Patients With Acute Knee Injury In The Near Аnd Long-Term Period Through The Introduction Of Tactics Of Early Arthroscopy., M.Yu. Karimov

Central Asian Journal of Medicine

Aim: to improve the results of surgical treatment of patients with acute knee injury in the near and long-term period by introducing tactics of early arthroscopy. Material and methods: To achieve this goal, we conducted a prospective study of the long-term results of treatment of 75 patients with post-traumatic hemarthrosis treated in the Department of traumatology of the 2nd clinic of TMA. Result: Arthroscopic intervention in patients of the main group, allowed us to diagnose missed on MRI meniscus rupture in 10 (27%) cases, damage to the ACL in 5 (13.5%) and PCL in 1 (2.7%) case; the presence of …


Сharacter And Peculiarities Of Mechanical Injuries Of Larynx Complex, S.I. Indiaminov Mar 2019

Сharacter And Peculiarities Of Mechanical Injuries Of Larynx Complex, S.I. Indiaminov

Central Asian Journal of Medicine

Aim: The study of the nature and characteristics of the course of mechanical damage of the complex larynx for the tasks of forensic medical examination. Material and methods: On the material of expertise special methods were investigated 12 cases on injured complex of larynx, occurring on variety types of enforced death. Result: It has been established that, in general, the mechanisms of formation of injuries of the hyoid bone, thyroid cartilage and cricoid cartilage from compression of the neck by a loop and mechanical injury are similar to each other, since the localization and nature of fractures depends on the …


Effects Of Diterpene Alkaloids Zongorin And 1–O–Benzoylnapellin Onсоntractile Activity Of Rat Aorta Smooth Muscle, A.T. Yesimbetov Mar 2019

Effects Of Diterpene Alkaloids Zongorin And 1–O–Benzoylnapellin Onсоntractile Activity Of Rat Aorta Smooth Muscle, A.T. Yesimbetov

Central Asian Journal of Medicine

Aim: The effects of diterpene alkaloid zongorin and 1–O– benzoylnapellin on contractile activity of rat aorta smooth muscle were investigated. Material and methods: Contractile activity of rat aortic smooth muscle, precontracted with high KCl and phenylephrine, was evaluated by mechanographic technique using isometric force transducer FT–03(Grass–Telefactor, USA). Results: Both alkaloids in dose–dependent manner inhibited aortic rings contraction induced by 50 mMKCl. These effects of zongorin and 1–O–benzoylnapellinwere significantly reduced in the absence of extracellular Ca2+ or in the presence of verapamil, which more potently inhibited the effect of zongorin. In contrast to zongorin 1–O–benzoylnapellin also potently inhibited the contraction induced …


Modern Condition Of The Problem Of Lipid Peroxide Oxidation, B.U. Iriskulov Mar 2019

Modern Condition Of The Problem Of Lipid Peroxide Oxidation, B.U. Iriskulov

Central Asian Journal of Medicine

This article assesses the state of the problem of lipid peroxidation. Free radical processes are highly reactive, and are essential components of the normal functioning of cells. Hydrogen peroxide, hydroxyl radicals, superoxide radicals and singlet oxygen are known. The formation of the radical anion of oxygen and hydrogen peroxide leads to a "respiratory explosion" (an increase in the consumption of oxygen by neutrophils, macrophages, etc.). In peroxisome oxidase, oxygen is reduced to hydrogen peroxide (urotoxicity, glycolate oxidase, L-amino acid oxidase). These radicals and reactive oxygen species (ROS) have a bactericidal effect.


Bronchial Asthma In Children: A Modern View Of The Problem, M.H. Mirrahimova Mar 2019

Bronchial Asthma In Children: A Modern View Of The Problem, M.H. Mirrahimova

Central Asian Journal of Medicine

Bronchial asthma is one of the most common chronic diseases. Statistical indicators of the prevalence of asthma are based mainly on data obtained from the treatment of patients in medical institutions. Therefore, information on the prevalence of bronchial asthma does not correspond to reality, as many patients for various reasons do not go to medical institutions, the parents of the child have a negative attitude towards diagnosing a chronic disease, and doctors often do not diagnose bronchial asthma, especially in the early stages of development and in cases of mild diseases. Thus, according to the Healthcare data of the Tashkent …


The Value Of Biological Markers In The Diagnosis, Prediction And Evaluation Of The Effectiveness Of Treatment Of Chronic Heart Failure, A.K. Kurbonov Mar 2019

The Value Of Biological Markers In The Diagnosis, Prediction And Evaluation Of The Effectiveness Of Treatment Of Chronic Heart Failure, A.K. Kurbonov

Central Asian Journal of Medicine

The author outlines modern information on biological markers, which describe the diagnosis, assessment of its transmission, monitoring of the treatment process and the possible adverse effects of the disease. The article highlights the importance of biological markers in the early detection of various phenotypes of СHF.


Short-Term Outcomes Of Laparoscopic Removal Of Ovary Cysts In Patients With Infertility Using Various Methods Of Surgical Hemostasis, D.K. Najmutdinova Mar 2019

Short-Term Outcomes Of Laparoscopic Removal Of Ovary Cysts In Patients With Infertility Using Various Methods Of Surgical Hemostasis, D.K. Najmutdinova

Central Asian Journal of Medicine

Aim: to study the short-term outcomes of laparoscopic removal of ovarian cysts using different methods of hemostasis (closure, monopolar, bipolar and ultrasound coagulation) in infertility patients. Material and methods: The prospective part of the study included 8 patients with ovarian cysts and infertility, who were operated on laparoscopically in the period from May to September 2018 under conditions of the Department of Gynecology No. 1 of the State Administration of the RSNPMTSAG. Retrospectively, the same criteria were analyzed in 32 patients with infertility, who in the period from 2017 to 2018. laparoscopic removal of ovarian cysts was performed. Results: The …


Short-Term Outcome Of Laparotomic Myomectomy With Transient Uterine Vessels Occlusion In Infertile Patient, D.K. Najmutdinova Mar 2019

Short-Term Outcome Of Laparotomic Myomectomy With Transient Uterine Vessels Occlusion In Infertile Patient, D.K. Najmutdinova

Central Asian Journal of Medicine

Aim: To evaluate the effectiveness of myomectomy with intraoperative temporary ligation of uterine vessels in patients with infertility. Material and methods: the study included data from 61 patients suffering from a combination of infertility and uterine fibroids, who required surgical treatment. All patients were operated on at the Department of Gynecology No. 1 of the State Administration of the Republican Specialized Scientific Center of Obstetrics and Gynecology in 2015-2018. The data of 43 retrospective analyzed patients who underwent myomectomy underwent a permanent uterus ligation procedure and 7 patients who underwent uterus ligation during myomectomy were not analyzed at all. The …


Algorithm Of Endoscopic Surgery Of Staghorn And Multiple Nephrolithiasis, Sh.T. Mukhtarov Mar 2019

Algorithm Of Endoscopic Surgery Of Staghorn And Multiple Nephrolithiasis, Sh.T. Mukhtarov

Central Asian Journal of Medicine

Aim: to optimize a tactics of endoscopic surgery for staghorn nephrolithiasis and increase a treatment efficacy of nephrolithiasis. Materials and methods: 158 patients with staghorn nephrolithiasis have been investigated and treated. Results: Using an algorithm of endoscopic surgery for staghorn nephrolithiasis have leaded to increase a stone clearance rate up to 90,0%. Conclusion: It is concluded that including an algorithm of endoscopic surgery for staghorn nephrolithiasis in the investigation and treatment have leaded to increase an efficacy of treatment of nephrolithiasis.


Comparative Evaluation Of Hepatoprotective Effects Of Katacin And Geranil On A Model Of Acute Toxic Liver Damage, Z.A. Khushbaktova Mar 2019

Comparative Evaluation Of Hepatoprotective Effects Of Katacin And Geranil On A Model Of Acute Toxic Liver Damage, Z.A. Khushbaktova

Central Asian Journal of Medicine

Aim: to evaluate the effectiveness of new domestic drugs (cavergal, geranyl and catacin) in the correction of the main hepatic syndromes: cytolysis, cholestasis, mesenchymal inflammation and hepatocellular insufficiency in a model of toxic liver damage. Material and methods: studies were conducted on 75 male rats with acute toxic liver damage, which was reproduced by administering heliotrin at a dose of 200 mg/kg, 8 rats were included into intact group. Biochemical studies of blood serum were performed on a biochemical analyzer. Result: experimental pharmacotherapy of acute toxic liver damage with new drugs katatsin and geranil significantly reduced rates of cytolysis, cholestasis, …


Surgical Treatment Of Postoperative Intrapleural Bleeding, Sh.N. Hudaybergenov Mar 2019

Surgical Treatment Of Postoperative Intrapleural Bleeding, Sh.N. Hudaybergenov

Central Asian Journal of Medicine

Aim: Intrapleural bleeding is a serious complication of the first hours and days after surgery. Judging by the literature, it occurs in 2-20% of cases. A timely retoracotomy removes the cause of bleeding and often saves the life of the patient. The goal is to form and improve the tactics of treatment of postoperative intrapleural bleeding. Material and methods: The main group - 109 patients, these are patients operated on after 2006, the control group until 2006 - 225 patients. The tactics of managing patients with intrapleural complications differed in the set of new technologies introduced in parallel in the …


Intensity Of Wearing Details Of Ice When Operating In Motor Oil Without And With Antimicrobial Additives And Their Analysis, O.O. Mukhitdinov, M.M. Toshpulatov Mar 2019

Intensity Of Wearing Details Of Ice When Operating In Motor Oil Without And With Antimicrobial Additives And Their Analysis, O.O. Mukhitdinov, M.M. Toshpulatov

Acta of Turin Polytechnic University in Tashkent

The presence of solid contaminants, in engine lubricating oil, impacts negatively on the performance of the engine and increase fuel consumption. All types of machines and parts get worn out due to continuous usage and working. Decent maintenance and everyday checks are mandatory to ensure that the machines work for a longer time. During the operation of the machinery, wear occurs whenever there is interaction between moving surfaces, which causes the formation of wear particles from the moving parts resulting in their continual degradation. Wear is an unavoidable phenomena of surface contact between engine parts. Proper use of additives with …


110th Anniversary Of Hamid Olimjon Unique Talent And Colorful Creation, Usmonjon Kasimov, Yulduz Karimova Mar 2019

110th Anniversary Of Hamid Olimjon Unique Talent And Colorful Creation, Usmonjon Kasimov, Yulduz Karimova

Mental Enlightenment Scientific-Methodological Journal

The article examines the socio-aesthetic factors that led to the growth of Hamid Olimjon, a representative of twentieth-century Uzbek literature, as a talented literary critic and public figure, the role and importance of the poet's literary heritage in the development of our literature and spirituality.


Artistic Thinking And Artistic Interpretation, Zulfiya Juraevna Pardaeva, Arslon Keldibekovich Djanzakov Mar 2019

Artistic Thinking And Artistic Interpretation, Zulfiya Juraevna Pardaeva, Arslon Keldibekovich Djanzakov

Mental Enlightenment Scientific-Methodological Journal

The article reveals the stylistic diversity of works of art created in Uzbek novel in the last decade of the XX century and the beginning of the XXI century, the depth of epic observation, the existence of syncretic styles in poetic stylistics.


Socio-Philosophical Interpretation Of The Category Of National Character, B. Toshboev, Sh. Eshboyev Mar 2019

Socio-Philosophical Interpretation Of The Category Of National Character, B. Toshboev, Sh. Eshboyev

Mental Enlightenment Scientific-Methodological Journal

No abstract provided.


Interactive Learning Environment In The English Language Teaching With The Help Of Computer Technology, Gulruh Norbekova, Dildora Safarova, Bunyod Bazarov, Fazliddin Yakubov Mar 2019

Interactive Learning Environment In The English Language Teaching With The Help Of Computer Technology, Gulruh Norbekova, Dildora Safarova, Bunyod Bazarov, Fazliddin Yakubov

Mental Enlightenment Scientific-Methodological Journal

In current education sphere it is easy to develop interactive learning environment to encourage our students to learn something with great interest as advanced information and communication technology enables to create a number of new ways to teach foreign languages. As Wasson says interactive learning environment has an important role in teaching and learning and will also have in the future. Specifically, interactive learning environment always supports to discover, create, think critically, convey something in different way than it is expected to be or used to be. In this article we focus on the ways of how to create interactive …


Ancient Jizzakh - On The Historical Topography Of Kaliyatepa, M. Pardaev, Sh. Pardaev Mar 2019

Ancient Jizzakh - On The Historical Topography Of Kaliyatepa, M. Pardaev, Sh. Pardaev

Mental Enlightenment Scientific-Methodological Journal

No abstract provided.


The Role Of Citizenship Responsibility In Ensuring Socio-Political Stability, Akbar+E5e2:E10 Saitkasimov Mar 2019

The Role Of Citizenship Responsibility In Ensuring Socio-Political Stability, Akbar+E5e2:E10 Saitkasimov

Mental Enlightenment Scientific-Methodological Journal

Social-political stability one of the important factors of building democratic, fair society, any kind of development that is necessary in terms of workmanship, positive changes in citizens life of stability of the society, the role social activity of the people and civil responsibility in providing social-political stability of society is analyzed in this article.


Toponyms And The Expressıon Of “Toponymıcal Conceptual Semantıcs” In Them, Gulnoza Zakhirovna Ganiyeva Mar 2019

Toponyms And The Expressıon Of “Toponymıcal Conceptual Semantıcs” In Them, Gulnoza Zakhirovna Ganiyeva

Mental Enlightenment Scientific-Methodological Journal

This article is devoted to analyses of toponymical conceptual semantics in toponyms. The issues of cognitology, concept of “place”, toponymical conceptual semantics in toponyms and its appearance in the language have also taken in the article.


Methodological Strategies To Teach Foreign Languages In Primary Schools, Dildora Safarova Mar 2019

Methodological Strategies To Teach Foreign Languages In Primary Schools, Dildora Safarova

Mental Enlightenment Scientific-Methodological Journal

This article represents the discussions and solutions by educational psychologists on how to teach foreign languages in primary schools and how to cope with the problems that language teachers often face while teaching primary school pupils. Furthermore, some effective methodological points by the author have been given to handle the difficulties occurring in language teaching classes.


Phraseological Meaning: Lingvopragmatic Approach, Abdugafur Mamatov Mar 2019

Phraseological Meaning: Lingvopragmatic Approach, Abdugafur Mamatov

Mental Enlightenment Scientific-Methodological Journal

This article is interpreted on the basis of the issues of linguopragmatic formation of the meaning of phraseological units. It expresses such features as the transfer of phrases and sentences, spontaneity, the formation of phraseological meaning on the logical basis of lexemes.


Theoretical And Practical Issues Of Technical Terminology, Fotima Bakhromovna Abdullaeva, Oman Risaliyevich Isarov Mar 2019

Theoretical And Practical Issues Of Technical Terminology, Fotima Bakhromovna Abdullaeva, Oman Risaliyevich Isarov

Mental Enlightenment Scientific-Methodological Journal

The article analyzes the current theoretical and practical issues of terminology, in particular, technical terminology. A diachronic study was conducted on the creation and study of technical terminology. The views of terminologists have been studied from an analytical-critical point of view


The Inner World Of A Woman "Mrs. Dalloway", By Virginia Woolf, Umida Fayzullaeva Mar 2019

The Inner World Of A Woman "Mrs. Dalloway", By Virginia Woolf, Umida Fayzullaeva

Mental Enlightenment Scientific-Methodological Journal

Following work is dedicated to how Virginia Woolf refuses external action, focusing on the image of the entire diversity of the inner life of her characters. Instead of a dynamic plot, the fundamental role of the images of the main character and the author-narrator, for the English writer, the unifying factors of the entire narrative are the close and thoughtful relationship of the characters in time and space.


Phraseological Meaning: Lingvopragmatic Approach, A. Mamatov Mar 2019

Phraseological Meaning: Lingvopragmatic Approach, A. Mamatov

Mental Enlightenment Scientific-Methodological Journal

This article is interpreted on the basis of the issues of linguopragmatic formation of the meaning of phraseological units. It expresses such features as the transfer of phrases and sentences, spontaneity, the formation of phraseological meaning on the logical basis of lexemes.


Phraseological Formation And Lexicalization Phenomenon, Abdugafur Mamatov Mar 2019

Phraseological Formation And Lexicalization Phenomenon, Abdugafur Mamatov

Mental Enlightenment Scientific-Methodological Journal

This article analyzes the formation features of phraseological units and phraseological issues, stating that phraseological units as lexical units, their place in the language system, a linguistic unit formed on the basis of linguistic and non-linguistic factors, have lexical, semantic, grammatical and functional significance.