Digital Commons Network^™

The Impact Of Arginase1, Malondialdehyde Levels And The Activity Of Glutathione S-Transferase On The Development And Progression Of Diabetic Retinopathy In Some Iraqi Patients, Maha Faris Yaseen, Fayhaa M. Khaleel

Baghdad Science Journal

Diabetic retinopathy (DR) is the major cause of blindness due to microvascular damage from high blood glucose and lipid levels. Arginase1 is an enzyme that regulates β-cell activities, insulin resistance, and vascular complications, inflammatory responses, and oxidative stress. This study aimesto investigate the role of Arginase1 in Iraqi individuals with obesity, T2DM and DR and investigating the relationship with GST and MDA in the development of inflammation and oxidative stress that causes diabetic complication. This research included 120 participants: 40 obese controls, 40 diabetes Type 2 patients, and 40 diabetic retinopathy patients, aged 30–65, from both sexes. All groups …

A Study Of Dipeptidyl Peptidase-4 In Iraqi Patients With Coronary Artery Disease, Saja Taha Yissen, Layla Othman Farhan

Baghdad Science Journal

Heart and blood vessel illnesses are collectively referred to as cardiovascular diseases (CVD). Although there is, till now, no known cure for the deadly disease known as CAD, it is extremely predictable, treatable, and preventative. Dipeptidyl peptidase 4 (DPP4) is a single-pass transmembrane protein that regulates glucose levels and has several roles in the immune system, cell migration and proliferation, and other areas. The purpose of the study is to measure the DPP 4 levels in the sera of Iraqi patients with CAD. The DPP4 was measured in Iraqi patients' serum in the current investigation to evaluate, which included forty …

Synthesis, Characterization And Biological Activity Studies Of New Metal Ion Complexes With Schiff Base Derived From (Z)-3-Hydrazineylidene-1-Phenylpyrazolidine And Evaluating Them As Antioxidants, Zahra Mounir Ahmed, Naser Shaalan

Baghdad Science Journal

The research includes the preparation of several complexes of the transition elements and zinc where M(II) = Co, Ni, Cu, and Zn, containing the 3d shell, with ligand (LH)was synthesized by treating the (Z)-3-hydrazineylidene-1-phenylpyrazolidine and Salicylaldehyde. Ligand (LH) was identified using FT-IR spectra,¹H-¹³C-NMR, UV-Vis spectroscopy, elemental microanalysis CHN and mass spectrometry. The complexes were studied and identified with elemental microanalysis CHN, FT-IR spectroscopy, UV-Vis spectroscopy, conductivity measurement, and magnetic sensitivity. The result showed that, these complexes were classified as homogeneous tridentate complexes with the formula [M(LH) (H₂O)₂Cl] or [M(LH)₂]. xH …

Studying The Corrosion Inhibition Ability Of Metoclopramide Drug On The Copper Surface In Seawater And Theoretical Studies, Nafeesa J. Kadhim, Ahlam M. Farhan, Rasha A. Jassim, Muna S. Sando, Hawraa M. Abdulkareem, Taghried A. Salman

Baghdad Science Journal

Protection study of the corrosion behavior of Copper surface was conducted with several concentrations of drug. Experimentally, voltammetric measurements were used to check the inhibition efficiency (% IE) in saline solution of 3.5% NaCl. The results showed an increase in the inhibition efficiency with increasing the concentration of the drug was 95.90%. Theoretical treatment of the drug in the gas phase was performed using the (hyperchem-8.07) program for molecular mechanics and semi-empirical computations. The (PM3) approach was used to determine the heat of formation (ΔH˚f), binding energy (ΔEb), and total energy (ET) for durq at 298 K. To explore the …

Determination Of Ni (Ii) By Forming A New Complex N-(4-(Dimethyl Amino) Benzylidene)-3, 5-Dinitrobenzohydrazide Nickel (Ii) Chloride, Elham N. Mezaal, Kawther Ahmed Sadiq, Maha A. Mohammed

Baghdad Science Journal

In this research, the theme for employing a simple and sensitive method is to employ a new Schiff base ligand (N'-(4-(dimethyl amino) benzylidene)-3, 5-dinitrobenzohydrazide) to estimate Ni (II) to form orange complex (N-(4-(dimethyl amino) benzylidene)-3, 5-dinitrobenzohydrazide nickel (II) chloride) in acid medium (hydrochloric acid), it gives an absorption peak at the wavelength 485 nm. The preferred conditions were studied to form the complex and obtain the highest absorbance including concentration of Schiff base ligand, the best medium for complex formation, effects of addition sequence on complex formation, the effect of temperature on the absorbance of the complex formed, and the …

Preparation, Diagnosis, Theoretical Study, Biological Evaluation And Antioxidant Assay Of Zro2 Oxide Nanoparticles Using Environmentally Friendly Method, Wafaa Fayyad Tharp, Lekaa K. Abdul Karem

Baghdad Science Journal

This research included using an environmentally friendly method to synthesize nano particles of zirconium oxide using chamomile plant extract as a reducing agent in basic medium at pH 12, and then preparing the metal oxide using various techniques such as FTIR spectroscopy, scanning and transmission electron microscopy (SEM and TEM), energy-dispersive X-ray spectroscopy (EDX) to calculate the percentages of elements. The infrared spectrum showed the appearance of spectral bands at 559 and 441 cm^–1 due to the formation of the bond between the oxygen and zirconium. Depending on AFM analysis, the average mean size of ZrO₂ Nano partials …

Spectrophotometric And Flow Injection System For Sensitive Determination Of Hesperidin And Naringenin Using Chromogenic Reagent, Ali M. Salman, Sadeem Subhi Abed

Baghdad Science Journal

Methods with high precision and sensitivity have been developed to estimate Hesperiden (HSP) and Naringenin (NAR) levels in various samples, including capsules for medicines and urine. These techniques utilize a flow injection device and an alkaline medium to perform a coupling reaction using diazotized metoclopramide (DMP) as chromogenic reagent. The utilization of the diazotized reagent of metoclopramide is regarded as an environmentally friendly chromogenic reagent. The peak absorption wavelengths for HSP and NAR are 442 nm and 416 nm, respectively, indicating that yellow dyes exhibit the most outstanding absorption at these specific wavelengths. Calibration curves were generated using a range …

Preparation, Characterization, And Evaluation Of The Antioxidant Activity Of Chitosan Nano-Particles, Sura M. Abbood, Zahraa Raheem Murshidy, Aziz Y. H. Al-Ethari

Baghdad Science Journal

Nanotechnology is considered as a modern technique which provides useful characteristics to the nanomaterial including small size with high biological activity and the possibility to obtain novel nano-biohybrids through combining efficient and safe transport carriers with biological molecules. The nanohybrid chitosan has important applications in the food industry, due to its biochemical properties, such as biocompatibility, biodegradability, non-toxicity. The goal of this research is to develop environmentally friendly, economically feasible and a simple prepared natural nanohybrid antioxidant instead of artificial one, which is a main characteristic on a food industrial scale. The sol-gel ion exchange method was used to prepare …

Mechanism Of Immunotherapeutic And Anticancer Effects Of Moringa Peregrina Seed Extract On Non-Small-Lung Cancer, Nci-H460, Cell Line, Shaymaa Fadhel Abbas Albaayit, Maryam Kamel Mohammed, Ali Muhsin Ali, Rukesh Maharjan, Lubna M. Rasoul, Rasedee Abdullah, Mohd Hezmee Mohd Noor

Baghdad Science Journal

The Moringa peregrina plant possesses various therapeutic properties. This study determined the immunomodulatory and cytotoxic activities of M. peregrina seed ethanol extract (MPSE). Based on using gas chromatography-mass spectrometry analysis MPSE is rich in flavonoids, isothiocyanate, tocopherols, triterpenoids, and phenolics compounds. The immunomodulatory effect of MPSE was determined on whole blood and polymorphonuclear (PMNs) cells and macrophages. The in vitro antiproliferative effect was determined on the non-small-cell lung cancer, NCI-H460, cell line. Real-time quantitative PCR and flow cytometry were used to determine the expression of apoptotic genes in the MPSE-treated NCI-H460 cells. MPSE significantly (p < 0.001) suppressed whole blood, PMN cells and macrophage ROS production with IC50 values of 40.3 ± 0.3, 33.0 ± 0.6, and 26.1 ± 0.43 μg/mL, respectively. MPSE …

Study The Effect Of Pseudomonas Trivialis, Isolated From Soils Subjected To High Anthropogenic Pressure, On Plant Resistance To Salt Stress, Lyudmila I. Zaynitdinova, Nikolay A. Lazutin, Rokhila N. Juraeva, Rustam B. Ergashev, Javlon J. Tashpulatov, Natal’Ya G. Akinshina, Shokhsanam A. Safarova

Baghdad Science Journal

From soils exposed to anthropogenic load, a bacterial strain resistant to pollutants was isolated and characterized. The strain was identified as Pseudomonas trivialis 381 based on morphological, cultural, physiological and biochemical characteristics, as well as MALDI-TOF and 16S rRNA analysis. Its sequence was submitted to the NCBI GenBank (OR234684.1). Studies were conducted to evaluate the influence of the strain on seed germination and plant growth qualities. Laboratory studies have shown the stimulating effect of P. trvialis 381 on tomato seeds; seeds treated with the bacterial cultural liquid increased the energy of germination and seed germination to 100% (with the control …

Isolation And Purification Of Phytosterols From Euphorbia Milii Plant Cultivated In Iraq By Phplc And Evaluation Of Anticancer Activity, Z. O. Salman, Bushra M.J. Alwash, E. J. Kadhim

Baghdad Science Journal

Combined, plant sterols and stanols, substances structurally similar to cholesterol, are referred to as phytosterols. In plants, phytosterols serve the same purposes as cholesterol does in animals and people. This study’s primary goal was to compare two different cell line types to the extracted steroid and nano-steroid. PHPLC was used to isolate the novel steroid molecule from the Euphorbia milii plant in its pure form, and FT.IR was used to confirm its identity. The chemical had a retention time of 13.87. By using the chitosan-maleic complex process, nano-steroids were created. To evaluate produced nanoparticles, the Philips PW1730 XRD instrument was …

Senior Recital: Vazquez-Barragan, Voice; November 15, 2025, Miguel Vazquez-Barragan, Pepe Guillen-Prados

School of Music Programs

This is the sixty-first program of the 2025-2026 season.

Kemp Recital Hall

November 15, 2025

Saturday Evening

6:30 p.m.

Senior Recital: Garcia, Voice; November 15, 2025, Emma Garcia, Nadia Jensen

School of Music Programs

This is the sixty-second program of the 2025-2026 season.

Kemp Recital Hall

Saturday Evening

7:30 p.m.

Image-Based Meta- And Mega-Analysis (Ibmma): A Unified Framework For Large-Scale, Multi-Site, Neuroimaging Data Analysis, Jacklynn M. Fitzgerald

Psychology Faculty Research and Publications

The increasing scale and complexity of neuroimaging datasets aggregated from multiple study sites present substantial analytic challenges, as existing statistical analysis tools struggle to handle missing voxel-data, suffer from limited computational speed and inefficient memory allocation, and are restricted in the types of statistical designs they are able to model. We introduce Image-Based Meta- & Mega-Analysis (IBMMA), a novel software package implemented in R and Python that provides a unified framework for analyzing diverse neuroimaging features, efficiently handles large-scale datasets through parallel processing, offers flexible statistical modeling options, and properly manages missing voxel-data commonly encountered in multi-site studies. IBMMA successfully …

Quantum Readiness In Cybersecurity Education: A Framework For Preparing The Next Generation In The Post-Quantum Era, George Antoniou

Faculty and Staff Publications & Presentations

The rapid advancement of quantum computing represents both a revolutionary opportunity and an existential threat to contemporary cybersecurity infrastructure. While quantum computers promise unprecedented computational capabilities, they simultaneously pose a critical risk to current cryptographic protocols that protect sensitive data, financial systems, and national security frameworks. Post-quantum cryptography (PQC) standards, recently formalized by NIST in 2024, provide a roadmap for quantum-resistant encryption. However, a significant gap exists between technological advancement and educational preparedness, with most cybersecurity curricula failing to adequately prepare students for the quantum era. This paper addresses the urgent need for comprehensive quantum readiness in cybersecurity education across …

Lee Roy Brown

African American Funeral Programs

No abstract provided.

Mr. Grady Lee Mosley, Jr.

African American Funeral Programs

No abstract provided.

Characterizing The Metabolites Of The Tyrosine-Kinase Inhibitor Pexidartinib In Mouse Feces, Urine, Plasma, And Liver, Xuan Qin, Si Chen, John M Hakenjos, Jian Wang, Lei Guo, Ashish Dogra, Zhaoyong Hu, Kevin R Mackenzie, Feng Li

Faculty, Staff and Students Publications

Pexidartinib (PEX, TURALIO®), a tyrosine kinase inhibitor, is approved for treating tenosynovial giant cell tumor in adults. However, its potential to cause fatal liver injury has prompted the U.S. FDA to issue a black box warning, and the mechanisms underlying its hepatotoxicity remain largely unknown. As biotransformation may contribute to PEX-induced hepatotoxicity, understanding its metabolism is essential. Our previous research indicated that PEX forms reactive metabolites in human and mouse liver microsomes and in human hepatocytes. We investigated PEX metabolism and liver distribution in mice with a focus on metabolite characterization. Our data shows that PEX is mainly excreted into …

Comparing The Effects Of Ect And Intravenous Ketamine In Psychiatric Patients With Major Depressive Episodes, Julia Myerson, Katrina A Rufino, Sanjay J Mathew, Marie Fletcher, Neil Puri, Hyuntaek Oh

Faculty, Staff and Students Publications

Background: Electroconvulsive therapy (ECT) and intravenous (IV) ketamine are treatments used for severe depression and/or treatment-resistant depression (TRD). ECT is considered one of the most effective treatments for severe depression, although there is debate within the field regarding the effectiveness between ECT and IV ketamine in comparable TRD patient groups.

Methods: This retrospective chart review of open-label, nonrandomized treatment from a psychiatric hospital compared the effects of up to three weeks of ECT and IV ketamine in patients with major depressive episodes (MDEs). Our cohort included 146 inpatients and outpatients aged 18 to 74 years old. 94 patients received subanesthetic …

Forecasting Pediatric Emergency Department Arrivals: Evaluating The Role Of Exogenous Variables Using Deep Learning Models, Egbe Etu Etu, Jordan Larot, Kindness Etu, Joshua Emakhu, Sara Masoud, Imokhai Tenebe, Gaojian Huang, Satheesh Gunaga, Joseph Miller

Faculty Research, Scholarly, and Creative Activity

Background Forecasting pediatric emergency department (ED) demand remains a critical challenge in healthcare operations. This study aimed to identify exogenous variables influencing pediatric ED visits and evaluate the performance of different forecasting models. Method Using a retrospective observational design, we analyzed 192,347 pediatric ED visits across nine hospitals in Southeast Michigan between 2017 and 2019. Patient data were aggregated into daily arrival counts and enriched with exogenous variables such as weather, air quality, pollen, calendar, Google search trends, and chief complaints. Feature selection was performed using XGBoost and SHapley Additive exPlanations to identify the most influential predictors. Three forecasting models …

Image-Based Meta- And Mega-Analysis (Ibmma): A Unified Framework For Large-Scale, Multi-Site, Neuroimaging Data Analysis, Nick Steele, Ashley A Huggins, Rajendra A Morey, Ahmed Hussain, Courtney Russell, Benjamin Suarez-Jimenez, Elena Pozzi, Hadis Jameei, Lianne Schmaal, Ilya M Veer, Lea Waller, Neda Jahanshad, Sophia I Thomopoulos, Lauren E Salminen, Miranda Olff, Jessie L Frijling, Dick J Veltman, Saskia B J Koch, Laura Nawijn, Mirjam Van Zuiden, Li Wang, Ye Zhu, Gen Li, Dan J Stein, Jonathan Ipser, Yuval Neria, Xi Zhu, Orren Ravid, Sigal Zilcha-Mano, Amit Lazarov, Jennifer S Stevens, Kerry Ressler, Tanja Jovanovic, Sanne J H Van Rooij, Negar Fani, Sven C Mueller, Anna R Hudson, Judith K Daniels, Anika Sierk, Antje Manthey, Henrik Walter, Nic J A Van Der Wee, Steven J A Van Der Werff, Robert R J M Vermeiren, Christian Schmahl, Julia I Herzog, Ivan Rektor, Pavel Říha, Milissa L Kaufman, Lauren A M Lebois, Justin T Baker, Isabelle M Rosso, Elizabeth A Olson, Anthony King, Israel Liberzon, Michael Angstadt, Nicholas D Davenport, Seth G Disner, Scott R Sponheim, Thomas Straube, David Hofmann, Guangming Lu, Rongfeng Qi, Xin Wang, Austin Kunch, Hong Xie, Yann Quidé, Wissam El-Hage, Shmuel Lissek, Hannah Berg, Steven E Bruce, Josh Cisler, Marisa Ross, Ryan J Herringa, Daniel W Grupe, Jack B Nitschke, Richard J Davidson, Christine Larson, Terri A Deroon-Cassini, Carissa W Tomas, Jacklynn M Fitzgerald, Jeremy Elman, Matthew Panizzon, Carol E Franz, Michael J Lyons, William S Kremen, Brandee Feola, Jennifer U Blackford, Bunmi O Olatunji, Geoffrey May, Steven M Nelson, Evan M Gordon, Chadi G Abdallah, Ruth Lanius, Maria Densmore, Jean Théberge, Richard W J Neufeld, Paul M Thompson, Delin Sun

Faculty, Staff and Students Publications

The increasing scale and complexity of neuroimaging datasets aggregated from multiple study sites present substantial analytic challenges, as existing statistical analysis tools struggle to handle missing voxel-data, suffer from limited computational speed and inefficient memory allocation, and are restricted in the types of statistical designs they are able to model. We introduce Image-Based Meta- & Mega-Analysis (IBMMA), a novel software package implemented in R and Python that provides a unified framework for analyzing diverse neuroimaging features, efficiently handles large-scale datasets through parallel processing, offers flexible statistical modeling options, and properly manages missing voxel-data commonly encountered in multi-site studies. IBMMA successfully …

Interpretable Machine Learning Frameworks For Detecting And Characterizing Adaptive Processes In Genomic Data, Md Ruhul Amin

Electronic Theses and Dissertations

Detecting genomic regions influenced by adaptive processes is fundamental to understanding adaptation and its connection to modern human traits. Traditional summary-statistic and likelihood methods capture only simple evolutionary scenarios, while deep learning models such as convolutional neural networks, though powerful, often lose spatial information and lack interpretability. This dissertation introduces three complementary frameworks that overcome these limitations by integrating interpretable machine learning with spatially structured genomic data. The first framework, T-REx employs tensor decomposition to extract informative features from haplotype alignment images, enabling accurate classification of selective sweeps with classical learning models. The second framework, α-DAWG applies wavelet and curvelet …

Unveiling Novel Bladder Cancer Associations From Multicentred Primary And Secondary Care Electronic Health Records By Machine Learning: A Case-Control Study, Xu Wang, Andrea Preston, Jonathan Aning, Shang-Ming Zhou

School of Nursing and Midwifery

ObjectiveThe rising incidence and mortality in bladder cancer (BC) underscore the importance of identifying asscociated features. Current reliance on haematuria as a primary indicator for BC proves inadequate. While mining electronic health records (EHRs) offer potential of identifying BC-related signals, traditional data-driven methods struggle with high-dimensional datasets. This study aims to uncover novel BC-associated clinical signals by developing Parsimony-driven cAtegory-balaNced binary Signal extractor for Primary Care EHRs (PanSPICE) tailored to extremely high-dimensional data linked from multi-centres.MethodsWe collected BC cases and control patients (n = 64,884) linked at patient-level from Welsh nationwide databases, yielding 48,261 features in primary care settings. The …

Artificial Light At Night Alters Seaweed Reproductive Phenology, Emma Moyse, Louise Firth, Tim Smyth, Thomas Davies

School of Biological and Marine Sciences

Artificial light at night (ALAN) is a growing, globally prevalent environmental stressor. It is known to disrupt biological processes across taxa and biomes, including reproductive phenology in terrestrial plants, but its potential to alter reproductive timings in marine macroalgae remains unexplored. We used reflectance spectrometry to quantitatively assess changes in receptacle ripeness of three fucoid macroalgae species at four field sites along an ALAN gradient in Plymouth Sound, UK over a six-month period. At sites with elevated ALAN (measured using Sky Quality Meters, range 16.15–18.76 mag arcsec ⁻², equivalent to 3.75 × 10 ⁻²–3.38 × 10 ⁻³ cd/m …

In Vitro And In Vivo Evaluation Of Autochthonous Probiotics And Their Effects On The Mucosal Health Of Nile Tilapia (Oreochromis Niloticus), Sherilyn T. Abarra, Sahya Maulu, Sheu G. Odu-Onikosi, Taofik A. Momoh, Benjamin Eynon, Matthew Emery, Mark Rawling, Daniel L. Merrifield

School of Biological and Marine Sciences

The host microbiome is a promising source of probiotics for aquaculture species including Nile tilapia. In this study, the probiotic potential of autochthonous bacterial isolates from Nile tilapia and carp mid-intestines were screened in vitro. Two isolates (C61 and T70), closely related to Bacillus subtilis, exhibited antagonistic activity against multiple pathogen species and demonstrated multiple digestive enzyme activities. Their antagonistic activity in Aeromonas hydrophila assays remained even under simulated intestinal juice (SIJ) exposure. Subsequently, C61 (PT1) and T70 (PT2) were added to experimental diets at log 7 CFU/g of diet, and fed to Nile tilapia (5.32 ± 0.12 g) for …

Generation And Characterization Of A Knockout Mouse Of An Enhancer Of Ebf3, Emily Cordova Hurtado, Janine M Wotton, Alexander Gulka, Crystal Burke, Jeffrey K Ng, Ibrahim Bah, Juana Manuel, Hillary Heins, Stephen A Murray, David U Gorkin, Jacqueline K White, Kevin A Peterson, Tychele N Turner

2020-Current year OA Pubs

Genomic studies of neurodevelopmental disorders (NDDs) have identified several relevant genomic variants. EBF3 is a gene with an excess of protein-coding de novo variants and underlies Hypotonia, Ataxia, and Delayed Development Syndrome. We previously identified noncoding de novo variants in an enhancer of EBF3 and further found enrichment of deletions of this enhancer in NDDs. In this study, we generated a novel mouse line that deletes the highly conserved, orthologous mouse region within the Rr169617 regulatory region, and characterized the molecular and phenotypic aspects of this mouse model. We found a deviation from Mendelian expectation (P=0.02) with significant depletion of …

Evaluation Of The Impact Of Coriander Sativum Extract On The Modulation Of Inflammatory And Oxidative Enzymes In Ptz Induced Epilepsy In A Rat Model, Rusul Ali Kadhim, Zahraa Saleem Manji

Maaen Journal for Medical Sciences

Background

Recurrent and spontaneous seizures are a symptom of the epilepsy. It affects up to 65 million individuals globally, with lower-income nations accounting for 80% of cases. Since medicinal plants have special therapeutic qualities, they are frequently used to manage and cure epilepsy and convulsions. Because they have fewer side effects and stronger therapeutic results, medicinal plants are becoming more and more popular worldwide as a result of increased research and clinical use. The pharmaceutical industry is now concentrating heavily on the creation of novel plant-based antiepileptic/anticonvulsant drugs

Aims of the study:

Study the role of coriander sativum extraction in …

Torts And Pesticide Drift: Amending Right-To-Farm Acts In The Wake Of Widespread Dicamba Drift By Nicholas Brown** And Matt Roessing*

Journal of Legal Studies in Business

When crops die in a field prior to harvest, a farmer loses a portion of his salary for that year. When the cause of the crop loss is natural, farmers can usually seek compensation through crop insurance and government commodity support programs. When the crops were lost as a result of pesticide drift, these forms of compensation are not usually available to farmers.1 In order to make up for their losses, farmers can seek damages through judicial redress. For many decades, various state and federal laws have combined to complicate and at times prevent farmers adversely affected by pesticide drift …

Cover Page & Table Of Contents - Volume 23

Journal of Legal Studies in Business

JLSB vol. 23 Title Page & Table of Contents

Latine Doctoral Student Experiences In U.S. Counselor Education And Supervision Programs, Nayara Aparecida Da Costa Silva Beall, Lizbeth Duran Oden, Isabel C. Farrell, Mariaimeé Gonzalez, Stephanie Thorson-Olesen

Journal of Counselor Preparation and Supervision

This study explored the experiences of Latine doctoral students in Counselor Education and Supervision programs in the United States. The consensual qualitative research yielded five domains: cultural values, representation, racialized experiences, support, and social justice. The findings are discussed with direct applications for programs and recommendations for future research.