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Articles 121531 - 121560 of 5156547
Full-Text Articles in Entire DC Network
Comparison Of The Bioactivities Of Ziziphus Jujuba Polysaccharide And Its Degradation Products, Chunling Zhou, Xiaoyan Huang, Xuan Zheng, Ju Zhang
Comparison Of The Bioactivities Of Ziziphus Jujuba Polysaccharide And Its Degradation Products, Chunling Zhou, Xiaoyan Huang, Xuan Zheng, Ju Zhang
Journal of Food Science and Biotechnology
[Objective ] This study aims to compare Ziziphus jujuba polysaccharide (ZJP) and its degradation products in terms of their chemical composition and bioactivities.[Method ] ZJP was degraded by α-L-rhamnosidase,cellulase,snail enzyme,and trifluoroacetic acid to prepare different degradation products (ZJP-R,ZJP-C,ZJP-S,and ZJP-T ),and the chemical composition and degradation effects were compared.On the basis of in vitro antioxidant and probiotic activities,the in vivo antioxidant,anti-aging,anti-stress,and neuroprotective activities of ZJP and its degradation products were compared with Caenorhabditis elegans as a model system.[Result ] The mass fraction of reducing sugar and average degree of polymerization of ZJP showed significant variations among different degradation treatments.In addition,Sephadex G- …
Immunomodulatory Effects And Marker Components Of Alcohol Extract From Acanthopanax Senticosus (Rupr . Et Maxim .) Harms- Ganoderma Applanatum (Pers.) Pat., Lihong Wang, Kairui Sheng, Ming Lu, Jin Su, Yang Ping, Yu Zhang, Ji Zhao, Yixia Gong
Immunomodulatory Effects And Marker Components Of Alcohol Extract From Acanthopanax Senticosus (Rupr . Et Maxim .) Harms- Ganoderma Applanatum (Pers.) Pat., Lihong Wang, Kairui Sheng, Ming Lu, Jin Su, Yang Ping, Yu Zhang, Ji Zhao, Yixia Gong
Journal of Food Science and Biotechnology
[Objective ] The aim of this study was to analyze the compositional changes of the alcohol extracts of Acanthopanax senticosus (Rupr.et Maxim.) Harms (APS )-Ganoderma applanatum (Pers.) Pat.(GA) before and after compounding at a mass ratio of 5∶1 (mAPS∶mGA=5∶1) and to investigate the immunomodulatory effects and marker components of the extracts.[Method ] The mouse models of compromised immunity and delayed-type hypersensitivity (DTH ) were established with cytoxan (CTX ) and 2,4-dinitrochlorobenzene (DNCB ),respectively,to investigate the effects of the alcohol extracts on the immune system.Ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS ) was used to analyze the changes of the active ingredients …
Effects And Differences Of (+)-Catechin And (-)-Epicatechin On Antioxidant Activity Of Hek 293t Cells, Chang Sun, Ning Xia, Chao Wang, Fengxian Qin, Chengyu Lyu, Jian Liu, Tiezhu Li
Effects And Differences Of (+)-Catechin And (-)-Epicatechin On Antioxidant Activity Of Hek 293t Cells, Chang Sun, Ning Xia, Chao Wang, Fengxian Qin, Chengyu Lyu, Jian Liu, Tiezhu Li
Journal of Food Science and Biotechnology
[Objective ] This study aims to investigate the effects and differences of the natural antioxidant (+)-catechin and its isomer (-)-epicatechin on the antioxidant activity of HEK 293T cells based on the nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE ) pathway.[Method ] The effects of (+)-catechin and (-)-epicatechin on the viability of HEK 293T cells were investigated via the methyl thiazolyl tetrazolium (MTT ) assay.Reporter genes were employed to investigate the regulatory effects on the activation of ARE.The effects of (+)-catechin and (-)-epicatechin on the mRNA and proteins levels of the downstream factors [glutamate-cysteine ligase modifier subunit (GCLM …
Effects Of Α-Amylase Addition On The Characteristics Of Infant Rice Flour, Huihui Liu, Zhiyong Dai, Mengyi Li, Jiao Peng, Xing Meng, Luyan Liao, Rongbin Zhang
Effects Of Α-Amylase Addition On The Characteristics Of Infant Rice Flour, Huihui Liu, Zhiyong Dai, Mengyi Li, Jiao Peng, Xing Meng, Luyan Liao, Rongbin Zhang
Journal of Food Science and Biotechnology
[Objective ] This study aims to investigate the effects of α-amylase addition on the characteristics of infant rice flour.[Method ] Infant rice flour samples with different α-amylase addition were prepared.The basic composition,relative molecular mass of starch,gelatinization properties,hydration properties,texture properties,in vitro digestion characteristics,and microstructure of infant rice flour were determined.Furthermore,the correlations between the physicochemical characteristics and quality characteristics of infant rice flour were analyzed.[Result ] The weight-averaged molecular weight and the number-averaged molecular weight of starch in infant rice flour decreased with the increase in α-amylase addition.The gelatinization curve of infant rice flour with α-amylase addition was relatively gentle,and the gelatinization …
Effects Of Spices On Microbial Community Structure And Volatile Flavor Components Of Fuling Pickled Mustard Tuber, Ting Ren, Yuling Liu, Zhiping Zhao, Xiaoyong Chen, Yumei Peng, Hong Tao, Yuanli Luo
Effects Of Spices On Microbial Community Structure And Volatile Flavor Components Of Fuling Pickled Mustard Tuber, Ting Ren, Yuling Liu, Zhiping Zhao, Xiaoyong Chen, Yumei Peng, Hong Tao, Yuanli Luo
Journal of Food Science and Biotechnology
[Objective ] This study aims to investigate the effects of spices on the microbial community structure and volatile flavor compounds of Fuling pickled mustard tuber and explore the correlations between dominant microbial genera and volatile components.[Method ] The effects of spices on microbial community structure and volatile flavor components of Fuling pickled mustard tuber were investigated by high-throughput sequencing and headspace solid-phase microextraction (HS-SPME ) coupled with gas chromatography-mass spectrometry (GC-MS ).Pearson correlation coefficients were calculated to reveal the correlations between dominant microbial genera and volatile components.The mass fractions of total acids,nitrite,and reducing sugar were determined.[Result ] The dominant microbial …
Effects Of Shaping And Baking Processes On The Antioxidant Activity Of Round Roasted Green Tea, Jun Liu, Gong Feng, Rong Tan, Weihong Huang
Effects Of Shaping And Baking Processes On The Antioxidant Activity Of Round Roasted Green Tea, Jun Liu, Gong Feng, Rong Tan, Weihong Huang
Journal of Food Science and Biotechnology
[Objective ] This study investigated the effects of shaping and baking processes on the antioxidant activity of round roasted green tea,aiming to provide theoretical support and practical reference for improving the quality and optimizing the processing techniques of green tea.[Method ] The influences of different processing stages and key procedures such as shaping and baking on the antioxidant activity of round roasted green tea were studied.A zebrafish model (in vivo ) and multiple indexes including DPPH radical scavenging rate,ABTS ⁺ radical scavenging rate,and ferric ion reducing antioxidant power (FRAP ) were employed for comprehensive evaluation of the antioxidant activity.[Result ] …
Effects And Mechanisms Of Phytosterol-Oil Bodies Emulsion On Lipid Metabolism Of Caenorhabditis Elegans, Jie Sun, Mengyuan Yuan, Yifei Liu, Fuyao Zhang, Zhuofan Yang, Guoyou Yin
Effects And Mechanisms Of Phytosterol-Oil Bodies Emulsion On Lipid Metabolism Of Caenorhabditis Elegans, Jie Sun, Mengyuan Yuan, Yifei Liu, Fuyao Zhang, Zhuofan Yang, Guoyou Yin
Journal of Food Science and Biotechnology
[Objective ] This study aims to explore the lipid-lowering effects of the phytosterol-oil bodies emulsion (POE ).[Method ] Caenorhabditis elegans was taken as a model to evaluate the effects of POE on lipid metabolism,physiological indexes,and expression of genes associated with oxidative stress and fat metabolism.[Result ] Compared with the control group,different mass concentrations of POE reduced the mass fraction of fat (P<0.01) and the relative content of triglycerides (P<0.05),without toxicity to the growth and development of C.elegans (P<0.01).At the same time,it significantly reduced the level of reactive oxygen species and increased the levels of antioxidant enzymes.In addition,POE affected the expression levels of genes related to fat metabolism.qPCR results showed that POE up-regulated the mRNA level of sbp-1,while down-regulating the mRNA levels of fat-2,nhr-80,and fat-5 (P<0.05).[Conclusion ] POE may improve lipid metabolism by slowing fat deposition,regulating the fat peroxidation pathway,and alleviating oxidative stress in C.elegans.
Optimization Of Processing Technology And Analysis Of Volatile Components In Jinxuan Black Tea Cream, Yunxian Wang, Yunxiong Zhao, Lianfeng Luo, Baogui Liu, Jingjing Yang
Optimization Of Processing Technology And Analysis Of Volatile Components In Jinxuan Black Tea Cream, Yunxian Wang, Yunxiong Zhao, Lianfeng Luo, Baogui Liu, Jingjing Yang
Journal of Food Science and Biotechnology
[Objective ] This study is intended to optimize the preparation process of Jinxuan black tea cream,enhance the content of tea polyphenols,and compare the effects of different processing methods on the volatile components of the tea cream.[Method ] With dried Jinxuan black tea as the raw material,response surface methodology was adopted to examine the impacts of tea-to-water ratio,enzyme dosage,ultrasonic power,and ultrasonic duration on the mass fraction of tea polyphenols in the black tea cream.Furthermore,headspace solid-phase microextraction (HS-SPME ) coupled with gas chromatography-mass spectrometry (GC-MS ) was employed to detect and analyze the volatile components in the black tea cream samples processed …
Optimization Of The Fermentation Medium Of Aneurinibacillus Jxn- 1 For Caproic Acid Production, Guangdong Gan, Chunlin Zhang, Ting Huang, Junjun He, Chun Pu, Wei Shi, Mingye Peng, Tengfei Zhao
Optimization Of The Fermentation Medium Of Aneurinibacillus Jxn- 1 For Caproic Acid Production, Guangdong Gan, Chunlin Zhang, Ting Huang, Junjun He, Chun Pu, Wei Shi, Mingye Peng, Tengfei Zhao
Journal of Food Science and Biotechnology
[Objective ] This study aims to increase the caproic acid yield of Aneurinibacillus JXN- 1.[Method ] First,a Plackett-Burman design was employed to screen the significant factors affecting caproic acid yield from eight medium components.Subsequently,the path of steepest ascent method was used to determine the optimal concentration ranges of these significant factors.Finally,a Box-Behnken design was utilized to establish a quadratic polynomial regression model,and the interactions among the significant factors were analyzed to predict the optimal medium composition.[Result ] The Plackett-Burman design identified the mass concentration s of sodium acetate and calcium folinate and the volume fraction of ethanol as significant influencing …
Interview With Bill C. Robertson, Bill C. Roberston, Logan Dovalina
Interview With Bill C. Robertson, Bill C. Roberston, Logan Dovalina
Rio Grande Valley Oral Histories
Bill Robertson (September 15, 1943-June 20, 2026), a lifelong resident of Mission and McAllen, provides a first-hand account of the pioneer era and mid-20th-century social fabric of Mission, Texas, with particular emphasis on the exclusive Shary Heights subdivision.
Robertson traces his family’s arrival: his paternal grandfather entered the cotton business in Mission in 1908, while his maternal grandfather relocated from Vernon, Texas, to establish a citrus grove after purchasing land from developer John H. Shary. He vividly recalls the town’s earliest days, including cross-border bandit activity, homes lost to fire, and freezes, and the tight-knit circle of founding families (Shary, …
A Stability-Indicating Validated Rp-Hplc Method For The Determination Of Etoricoxib And It’S Degradants: Investigation Of Greenness And Functionality Of The Developed Method, Lama Ghazal, Iyad Allous, Mhd Amer Almardini
A Stability-Indicating Validated Rp-Hplc Method For The Determination Of Etoricoxib And It’S Degradants: Investigation Of Greenness And Functionality Of The Developed Method, Lama Ghazal, Iyad Allous, Mhd Amer Almardini
Baghdad Science Journal
Etoricoxib is a novel NSAID that belongs to selective COX-2 inhibitors. The aim of this research is to develop a precise, selective, cost-effective, and validated HPLC analytical method for the quantitative determination of Etoricoxib and its degradants. The analysis was implemented on a C18 column (150 × 4.6 mm, 5 μm particle size) using a mobile phase containing methanol and ammonium acetate (60:40) at a flow rate of 0.9 mL/min, with the Photodiode Array detector wavelength set at 234 nm. The method was validated according to USP43-NF38 guidelines and the International Conference on Harmonization recommendations. Linearity was established with …
The Rs1611770 Snp Polymorphism And Expression Of Mucin One Gene In Infertile Females In Baghdad, Iman Hamed Diab Al-Janabi, Asmaa M. Salih Almohaidi, Ibrahim Jasim Hammadi Al-Janabi
The Rs1611770 Snp Polymorphism And Expression Of Mucin One Gene In Infertile Females In Baghdad, Iman Hamed Diab Al-Janabi, Asmaa M. Salih Almohaidi, Ibrahim Jasim Hammadi Al-Janabi
Baghdad Science Journal
Infertility is the inability to become pregnant after six months or more of consistent, unprotected sexual activity. There are several causes of infertility, including hormonal, genetic, and environmental factors. The current investigation focuses on the polymorphism of SNP rs 1611770 in Mucin one gene and expression in infertility, considering a few demographic variables including age, body mass index and circumference of the abdomen. The current study included 30 infertile females and 30 fertile females. The mean BMI recorded Significant differences 28.76 ± 0.85 for infertile and 25.99 ± 0.65 for fertile, There are no significant differences in age and abdominal …
Shu World Review- November 15th 2025, Diplolab
State Of Nevada Cannabis Testing, University Of Mississippi – National Center For Cannabis Research And Education, Yasha Kahn, Mcr Labs
State Of Nevada Cannabis Testing, University Of Mississippi – National Center For Cannabis Research And Education, Yasha Kahn, Mcr Labs
Nevada
No abstract provided.
State Of California Cannabis Reporting, University Of Mississippi – National Center For Cannabis Research And Education
State Of California Cannabis Reporting, University Of Mississippi – National Center For Cannabis Research And Education
California
No abstract provided.
The Impact Of Organisational Culture On Innovative Work Behavior: Empirical Study On Egyptian Universities, Roqaya Negm
The Impact Of Organisational Culture On Innovative Work Behavior: Empirical Study On Egyptian Universities, Roqaya Negm
Business Administration
This study investigates the impact of organisational culture on Innovative Work Behaviour (IWB) among academic staff in Egyptian universities. It aims to clarify the inconsistent findings in existing literature by examining how diverse cultural dimensions influence IWB. Employing a positivist paradigm with quantitative methods, the research utilises the Competing Values Framework (CVF). Data were collected from academic staff in five public and private universities in Egypt, with analysis using regression analysis, T-tests, and ANOVA to differentiate between these institutional types. The study analyses the effects of various organisational cultural dimensions—adhocracy, clan, market, and hierarchy on IWB. The findings indicate that …
Comparative Study Of Interfacial Bond Strength Of Steel H-Pile With Ultra-High Performance And Polymer Concrete Jacket, Binod Shrestha, Mohanad M. Abdulazeez, Mohamed A. Elgawady
Comparative Study Of Interfacial Bond Strength Of Steel H-Pile With Ultra-High Performance And Polymer Concrete Jacket, Binod Shrestha, Mohanad M. Abdulazeez, Mohamed A. Elgawady
Civil, Architectural and Environmental Engineering Faculty Research & Creative Works
This study investigates the bond behavior of steel H-pile encased in concrete jackets under push-out loading, considering the effects of concrete type and embedment length. Nine full-scale specimens were tested using three concrete types: ultra-high-performance concrete (UHPC), Methyl Methacrylate Polymer Concrete (MMA-PC), and conventional concrete (CC), with embedment lengths of 63.5 mm, 127 mm, and 190.5 mm. The experimental results revealed that MMA-PC jacket demonstrated the highest bond strength, though gains were marginal beyond 127 mm. UHPC exhibited superior tensile strength and ductility, preventing splitting failure. UHPC also displayed the highest interfacial fracture energy of 9.63 N/mm, exceeding MMA-PC and …
Navigating Undergraduate Research In The Digital Era: A Qualitative Analysis Of Faculty Digital Practices And The Visibility Of Undergraduate Research Opportunities, Danielle Rukezo, Laamiah Mansuri, Southern Mullen, Madison Millen
Navigating Undergraduate Research In The Digital Era: A Qualitative Analysis Of Faculty Digital Practices And The Visibility Of Undergraduate Research Opportunities, Danielle Rukezo, Laamiah Mansuri, Southern Mullen, Madison Millen
Undergraduate Scholarly Works
This project examines undergraduate students’ experiences with research and the ways participation in undergraduate research supports academic, professional, and personal development.
Reimagining Youth Agency In Africa: Programs, Progress, And A Continental Vision (Closing Feature Article), Dennis Munene
Reimagining Youth Agency In Africa: Programs, Progress, And A Continental Vision (Closing Feature Article), Dennis Munene
Young African Leaders Journal of Development
This edition has curated the ideas, research, and praxis of young intellectuals and practitioners across the continent. As Vice President in charge of Programs and Development (Strategies), I am pleased to provide a retrospective of our continental programs and initiatives and project the path we envision in shaping Africa's future.
Decoding The Future: African Parliaments, The 4ir, And The Ai Revolution, Bravin Onditi, Immanuel Mwendwa Kiilu
Decoding The Future: African Parliaments, The 4ir, And The Ai Revolution, Bravin Onditi, Immanuel Mwendwa Kiilu
Young African Leaders Journal of Development
The Fourth Industrial Revolution (41R), propelled by advancements in Artificial Intelligence (AI), is ushering in a profound transformation across Africa's economies, governance systems, and societies. For African parliaments, there is an incredible challenge on the governance front, but the opportunities are unprecedented. This paper examines the range of biases, data insecurities, and inequalities the democracies of the continent face, while detailing how African legislatures can instate frameworks to govern and design AI function within the democracies of the continent. As seen in the examples of Rwanda, Kenya, South Africa, and Nigeria, this paper outlines the disparity between the astounding rates …
An Investigative Analysis Of How African Youth Can Drive Economic Integration By Taking Up Agriculture As A Means Of Economic Livelihood, Gerald Kihara Muchiri
An Investigative Analysis Of How African Youth Can Drive Economic Integration By Taking Up Agriculture As A Means Of Economic Livelihood, Gerald Kihara Muchiri
Young African Leaders Journal of Development
The paper explores how African youth can drive economic integration by using agriculture as an economic means of livelihood. Despite being Africa's most vital asset, African youth remain underrepresented in continental development initiatives and continue to stagnate as they face structural challenges such as perennial unemployment. The recent promulgation of the African Continental Free Trade Area and the Comprehensive Africa Agricultural Development Programme hold immense promise to improve the lives of millions of African youths if leveraged appropriately. This paper concludes that Africa's youth could be the continent's engine to propel sustainable economic growth if their potential is harnessed appropriately, …
Front Matter, Yaljod 5.1, Sombo Muzata
Front Matter, Yaljod 5.1, Sombo Muzata
Young African Leaders Journal of Development
Includes: Editorial Review by Dr. Sombo Muzata, Editor in Chief, Young African Leaders Journal of Development; Foreword by Prof. Plo-Lumumba; Foreword by Prof. Tim Kiruhi; and Preface by Prince C. lfoh, Founder and President, Young African Leaders Forum (YALF).
Promoting Women’S Land Ownership Rights In Tanzania: The Role Of Wlac As A Legal Empowerment Ngo, Norbeth Sixbert
Promoting Women’S Land Ownership Rights In Tanzania: The Role Of Wlac As A Legal Empowerment Ngo, Norbeth Sixbert
Young African Leaders Journal of Development
Despite Tanzania's progressive legal frameworks that recognize women's rights to own and inherit land, significant gaps remain between policy and practice. This paper explores the role of Non-Governmental Organizations (NGOs) in promoting women's land ownership rights, using the Women's Legal Aid Centre (WLAC) as a case study. Located in Kinondoni Municipal, Dar es Salaam, WLAC employs a multifaceted approach that empowers women and safeguards their land rights. While WLAC has achieved notable success, challenges exist and are exacerbated by overlapping statutory and customary legal systems that often disadvantage women. WLAC's multilateral engagement has helped to navigate these obstacles, yet structural …
Mainstreaming Africa’S Third Sector For Africa’S Development, Thoko J. Mthiko
Mainstreaming Africa’S Third Sector For Africa’S Development, Thoko J. Mthiko
Young African Leaders Journal of Development
After independence, most African governments pursued public sector based economic development strategies based on import substitution which were considered to be key to rapid industrialization and modernization oflow-income countries. This public sector-led economic development however, proved to be unsustainable. There were severe economic crises associated with lack of growth, high inflation, rising internal and foreign debts, crumbling infrastructure and shortage of essential commodities. Protected from competition, the public sector and its enterprises failed to innovate, relied on inappropriate capital-intensive technologies, and became dependent on imported inputs. With this, came the Structural Adjustment Programs (SAP's) where the public sector became the …
Coup-Proofing As A Tool For Authoritarian Survival In Central Africa: A Comparative Study Of Teodoro Obiang In Equatorial Guinea And Paul Biya In Cameroon, Prince Ifoh
Young African Leaders Journal of Development
For many African leaders, the most serious threat to their rule does not come from elections or public protests but from the people closest to them—the military and ruling elites. This paper examines how Teodoro Obiang Nguema of Equatorial Guinea and Paul Biya of Cameroon have remained in power for more than four decades by carefully reshaping their security institutions in ways that minimize coup risks. Drawing on established theories of authoritarian survival and a comparative analysis of both regimes, the research shows that they rely on a deliberate set of coup-proofing tactics, including the placement of trusted allies in …
Zakat For Financing Sustainable Development In Africa: Opportunities And Challenges, Shawgei Salah Ahmed Ismaeil
Zakat For Financing Sustainable Development In Africa: Opportunities And Challenges, Shawgei Salah Ahmed Ismaeil
Young African Leaders Journal of Development
The issue of Zakat and financing of SDGs has become an issue that economic, social and environmental researchers have raised, especially after the recent economic crisis. This is owing to Zakat dependence on the self-effort of societies and communities. Zakat supports the economic, social and environmental structure of societies. Africa, undoubtedly, needs to reduce poverty and hunger without preconditions by donors to change laws and the way of life of Africans. This task can be done through Islamic financing and Zakat. This paper puts this issue at the forefront of events for further study and research to rethink the practical …
Robotics In Agriculture: Challenges And Opportunities For Net-Zero – A Case For Africa, Oluwafemi Royal Aliu
Robotics In Agriculture: Challenges And Opportunities For Net-Zero – A Case For Africa, Oluwafemi Royal Aliu
Young African Leaders Journal of Development
Evidence of robotics and artificial intelligence (AI) are set to reposition the practice and process of agriculture. This study addressed vital issues in agriculture such as the need for a 70% increase in food production by 2050 because of population growth, technology, and other issues sweeping human livelihood, and are challenges of food insecurity which is currently affecting more than 820 million people globally. Emphasis was placed on the potential of robotics and artificial intelligence (AI) in curbing agricultural challenges in facts such as climate change, water scarcity, and pest management. The study identifies collaboration between different fields such as …
Yaljod Full Issue 5.1, Sombo Muzata
Yaljod Full Issue 5.1, Sombo Muzata
Young African Leaders Journal of Development
This issue brings together a compelling collection of scholarly articles that reflect the dynamic intersection of ethics, technology, governance, and social justice in Africa's development discourse. The contributions span diverse sectors including artificial intelligence, education, agriculture, legal empowerment, and economic integration. The articles offer both critical insights and actionable frameworks as Africa continues to implement its African Union Agenda 2063 plan. This work, written by up-and-coming African scholars demonstrates the commitment to scholarship on African issues, focused on Africa by Africans. This has been our goal at the Young African Leaders Journal of Development i.e., to advance scholarship on pertinent …
Interview No. 1805, Deana Garcia
Interview No. 1805, Deana Garcia
Combined Interviews
Deana Garcia was born in Miami, Florida, but spent most of her childhood in Lexington, Kentucky. Growing up, she was raised in the practices of the Baptist church, a branch of Christianity that, while different from other branches like Catholicism in terms of practices, still follows the same beliefs taught from the Bible. It was when meeting her husband that she learned more about Catholicism, which would become a big part of her adult religious life. Wanting to follow more of the Catholic church, she went to church when the opportunities came while she was still in the army and …
Inverse Design For Generating Initial Conditions In Scientific Simulations, Leslie Horace, Christin Whitton, Vanessa Job, William Jones, Nathan A. Debardeleben
Inverse Design For Generating Initial Conditions In Scientific Simulations, Leslie Horace, Christin Whitton, Vanessa Job, William Jones, Nathan A. Debardeleben
Computing Sciences
We propose a conditional normalizing flow (CNF) surrogate model to solve generative, many-to-one inverse problems in scientific simulations governed by partial differential equations (PDEs) with time-evolving interactions between heterogeneous materials. We present two case studies: electrostatic potential and heat diffusion, which serve as proxy simulations for generating diverse sets of initial conditions that can reproduce an observed output state (transient or steady). Finally, we provide a comprehensive overview of the synthetic datasets, the model specification, each stage of the experimental workflow, evaluation of training performance, and uncertainty quantification for the generated samples.