Digital Commons Network^™

Human Contributions To Safety Data Testbed Flight Simulation Study: Data Methods, Processing, And Quality, Tyler Fettrow, Chad Stephens, Lance Prinzel, Jon Holbrook, Kathryn Ballard, Sepehr Bastami, Michael Stewart, Daniel Kiggins

Faculty Research, Scholarly, and Creative Activity

NASA’s System-Wide Safety Project achieved a pivotal milestone through a structured observation simulation experiment aiming to transform safety in aviation. Building on prior initiatives, the study investigates pilot behavior and resilience during challenging scenarios. We studied 24 commercial pilots performing simulated real-world challenges during approach to KCLT such as traffic compression, convective weather, and modulating workload. We acquired standard human factors assessments like NASA-TLX and SART, and also collected a variety of psychophysiological measures such as EEG, ECG, and eye tracking. We employed custom questionnaires and retrospective think-aloud exercises to enable quantifying resilient and safe behavior. Video and audio were …

Experiences Of U.S. Frontline Physicians During The Covid-19 Pandemic: A Qualitative Study, Robin L. Whitney, Melissa Gosdin, Sabrina F. Loureiro, Marykate Miller, Joy Melnikow, Richard L. Kravitz

Faculty Research, Scholarly, and Creative Activity

Background: The COVID-19 pandemic caused profound and rapid changes in patient care and healthcare system organization. There is a compelling need for insight into the challenges that confronted physicians during the early phase of the pandemic to identify successful adaptations and strategies that minimize disruption to patient care and protect clinician wellbeing. The purpose of this study was to understand physicians’ lived experiences of providing patient care during the early COVID-19 pandemic. Methods: This qualitative, descriptive study used a thematic analysis approach. The sample included 17 physicians from five specialties with direct care experience of COVID-19 patients (infectious disease, primary …

Increased Melt From Greenland’S Most Active Glacier Fuels Enhanced Coastal Productivity, Michael Wood, Dustin Carroll, Ian Fenty, Clément Bertin, Basil Darby, Stephanie Dutkiewicz, Mark Hopwood, Ala Khazendar, Lorenz Meire, Hilde Oliver, Tara Parker, Josh Willis

Faculty Research, Scholarly, and Creative Activity

Seasonal phytoplankton blooms in Greenland’s coastal waters form the base of marine food webs and contribute to oceanic carbon uptake. In Qeqertarsuup Tunua, West Greenland, a secondary summertime bloom follows the Arctic spring bloom, enhancing annual primary productivity. Emerging evidence links this summer bloom to subglacial discharge from Sermeq Kujalleq, the most active glacier on the Greenland Ice Sheet. This discharge drives localized upwelling that may alleviate nutrient limitation in surface waters, yet this mechanism remains poorly quantified. Here, we employ a high-resolution biogeochemical model nested within a global state estimate to assess how discharge-driven upwelling influences primary productivity and …

Automated Design Of Scaffold-Free Dna Wireframe Nanostructures, Wen Wang, Abdulmelik Mohammed, Rong Chen, Antti Elonen, Silian Chen, Mengfan Tian, Junhao Yang, Ye Xiang, Pekka Orponen, Bryan Wei

Faculty Research, Scholarly, and Creative Activity

Computer-aided design has become common practice in DNA nanotechnology, and many programs are available that make the sophisticated design processes accessible to both the core research community and curious scientists in other fields. However, most of the design tools are committed to the scaffolded DNA origami method. Here we present an automated design pipeline for creating DNA wireframe nanostructures based on a scaffold-free molecular self-assembly approach. Unlike in the DNA origami method, scaffold-free designs are not built around a global backbone strand but are constituted entirely of short, locally intertwined oligonucleotides. This overcomes many limitations inherent in scaffolded nanostructure designs, …

Identifying Climate Refugia And Bright Spots For Highly Mobile Species, Nerea Lezama-Ochoa, Heather Welch, Jennifer A. Brown, Scott R. Benson, Karin A. Forney, Briana Abrahms, Mercedes Pozo Buil, Michael G. Jacox, Barbara A. Muhling, Owen R. Liu, Thomas A. Clay, Ryan Freedman, Danielle Lipski, Steven J. Bograd, Elliott L. Hazen, Stephanie Brodie

Faculty Research, Scholarly, and Creative Activity

Climate-driven shifts in species distributions can undermine the effectiveness of protected areas. We present a framework to facilitate climate change adaptation planning by identifying where highly migratory species habitats will persist (climate refugia), emerge (bright spots), disappear (dark spots), or remain unsuitable based on model analysis by 2100. When applied to eight species in the California Current System, we found that, on average, 37% of habitats are expected to be climate refugia, 9% are bright spots, and 13% are dark spots within National Marine Sanctuaries by 2100. Species responses differ: leatherback turtles may find refuge near U.S. coastal waters (18%), …

The (Birthweight) Gains From Trade: Chinese Imports And Infant Health In Sub-Saharan Africa, Jorge M. Aguero, Patralekha Ukil

Faculty Research, Scholarly, and Creative Activity

A growing literature has documented broad negative impacts of Chinese imports to advanced economies, mainly due to the competition of these imports with local production. However, for countries with a smaller manufacturing sector and which have not experienced a structural transformation away from agriculture, Chinese imports could have positive effects. We find evidence supporting this claim using a sample of over 350,000 births from 25 countries in Sub-Sahara Africa. Our identification compares the birthweight of biological siblings born at different levels of Chinese imports to their country. We find that an increase in Chinese imports of $100 (constant USD) is …

Common Severity-Based Definitions Of Bronchopulmonary Dysplasia Are Not Associated With Outpatient Morbidities, Robin L Mckinney, Antonia P Popova, Milenka Cuevas Guaman, Matthew J Kielt, Paul E Moore, Sharon A Mcgrath-Morrow, Joseph M Collaco

Faculty, Staff and Students Publications

Objectives: Bronchopulmonary dysplasia (BPD) is the most common complication of preterm birth, which can have life-long effects. Commonly used definitions of BPD severity are based on respiratory support at 36 weeks post-menstrual age. The utility of these definitions for tertiary referral centers outside the initial birth hospitalization is unclear.

Study design: Retrospective cohort study of infants born < 34 weeks gestation in the BPD Collaborative registry using three common definitions of BPD severity at 36 weeks post menstrual age and associated their severity with outpatient respiratory outcomes during the first 3 years of life.

Results: BPD severity by all three definitions was applied to 608 patients. Although the definitions had different distributions of BPD severity for the cohort, a majority of participants (75.7%) had moderate/Grade 2 or severe/Grade 3 BPD irrespective of the definition. Using clustered logistic …

Decreasing Barriers To The Utilization Of Cryopreserved Sperm In Male Cancer Survivors: An Expert Review And Guide, Megan V Alexander, Hailie Ciomperlik, Anna Claire Reynolds, Allyson Nevins, Luwam Ghidei, Jordan Kassab, Kevin Campbell, John Sullivan, Michael D Jochum, Laura Detti, Terri L Woodard, Larry I Lipshultz, Laurie J Mckenzie

Faculty, Staff and Students Publications

Background: Sperm cryopreservation offers male cancer patients a critical opportunity to preserve fertility prior to gonadotoxic therapy, yet utilization of banked sperm remains modest, typically under 10%. A structured understanding of barriers across the cancer survivorship continuum is needed to support patients in utilization of cryopreserved sperm in alignment with their reproductive goals.

Materials and methods: This expert review synthesizes current evidence and clinical experience to explore the multifaceted barriers to cryopreserved sperm use and propose specific solutions. Key intervention timepoints are examined, including the post-treatment fertility return visit, long-term cryopreservation while remote from family building, readiness for family building, …

Genetic And Environmental Determinants Of Streaming And Aggregation In Myxococcus Xanthus, Trosporsha T. Khan, Patrick Murphy, Jiangguo Zhang, Oleg A. Igoshin, Roy D. Welch

Faculty Research, Scholarly, and Creative Activity

Under starvation conditions, a spot of a few million Myxococcus xanthus cells on agar will migrate inward to form aggregates that mature into dome-shaped fruiting bodies. This migration is thought to occur within structures called ‘streams,’ which are considered crucial for initiating aggregation. The prevailing traffic jam model hypothesizes that intersections of streams cause cell crowding and ‘jamming,’ thereby initiating the process of aggregate formation. However, this hypothesis has not been rigorously tested, in part due to the lack of a standardized, quantifiable definition of streams. To address this gap, we captured time-lapse movies and conducted fluorescent cell tracking experiments …

A Morphological Cell Atlas Of The Freshwater Sponge Ephydatia Muelleri With Key Insights From Targeted Single-Cell Transcriptomes, Sally P. Leys, Lauren Grombacher, Daniel Field, Glen R.D. Elliott, Vanessa R. Ho, Amanda S. Kahn, Pamela J. Reid, Ana Riesgo, Emilio Lanna, Yuriy Bobkov, Joseph F. Ryan, April L. Horton

Faculty Research, Scholarly, and Creative Activity

How animal cell types, tissues, and regional body plans arose is a fundamental question in EvoDevo. Many current efforts attempt to link genetic information to the morphology of cells, tissues and regionalization of animal body plans using single-cell sequencing of cell populations. However, a lack of in-depth understanding of the morphology of non-bilaterian animals remains a considerable block to understanding the transitions between bilaterian and non-bilaterian cells and tissues. Sponges (Porifera), one of the earliest diverging animal phyla, pose a particular challenge to this endeavour, because their body plans lack mouths, gut, conventional muscle and nervous systems. With a goal …

A Novel Microfluidic Approach To Quantify Pore-Scale Mineral Dissolution In Porous Media, Rafid Musabbir Rahman, Elliott Niemur, Gianluca Blois, Farzan Kazemifar, Myeongsub Kim, Yaofa Li

Faculty Research, Scholarly, and Creative Activity

Mineral dissolution in porous media coupled with single- and/or multi-phase flows is pervasive in natural and engineering systems. Dissolution modifies the physical, hydrological, and geochemical properties of the solid matrix, resulting in a complex coupling between local dissolution rate and pore-scale flow. The work reports a microfluidic approach that includes 2D reactive porous media and advanced pore flow diagnostics for the study of pore-scale dissolution in porous media with unprecedented details. The 2D microfluidic porous media, called micromodels, were fabricated in calcite by combining photolithography and wet etching, which not only offers precise control over the structural and chemical properties, …

Balancing Earth Science Careers In An Unequal World, Nadia Testani, Lucía M. Cappelletti, Leandro B. Díaz, Camila Prudente, Valentina Rabanal, Julia Mindlin, Reyk Börner, Divya David T, Ismaila Diallo, Inés M. Leyba, Marisol Osman, Andrés Tangarife-Escobar

Faculty Research, Scholarly, and Creative Activity

Unequal research experiences among Earth scientists from around the world are an obstacle to achieving sustainability. We assess challenges and propose ways to balance the careers of early- and mid-career researchers in the Global South with those in the Global North.

Secondhand Social Capital And Idea Quality In Open Innovation Communities, Elisa Mattarelli, Aaron Schecter, Pamela Hinds, Noshir Contractor

Faculty Research, Scholarly, and Creative Activity

Open innovation communities provide valuable opportunities for creators from diverse backgrounds to collaboratively generate and refine new ideas that companies can implement in new products or services. However, many submitted ideas in these communities are underdeveloped or misaligned with companies' expectations, raising questions about what drives high-quality ideas and, more specifically, innovation potential. We focus on the role of secondhand social capital, i.e., the indirect network benefits an idea accrues through feedback from providers who are themselves actively engaged with other influential ideas in the community. While prior research has explored ego-centric or first-hand networks, we extend this work by …

Interactions Between Black, Brown, Blue And Green Carbon From Terrestrial To Marine Ecosystems: A Critical Review, Allison White, Richard Kline, Md. Saydur Rahman

School of Earth, Environmental, & Marine Sciences Faculty Publications

Black and brown carbon are byproducts of the incomplete combustion of biomass or fossil fuels. These light-absorbing aerosols influence climate by altering the radiative balance through the absorption and scattering of sunlight, exacerbating global climate change. Their subsequent deposition on terrestrial and marine environments affects surface albedo, snow and ice melt, and biogeochemical processes, leading to further environmental consequences. In contrast, green and blue carbon refer to carbon stored in terrestrial vegetation and marine ecosystems, respectively. These ecosystems play a crucial role in mitigating climate change by sequestering atmospheric carbon; however, they are increasingly threatened by climatic disturbances, anthropogenic activities, …

Abca4-Mutant Human Retinal Organoids Sequencing Reveals Organoids Application In Inherited Retinal Diseases, Yourong Bao, Sujung Soh, Jean Li, Zhen Zuo, Salma Ferdous, Xinye Qian, Jin Li, Jiaxiong Lu, Xuesen Cheng, Anna Matynia, Yumei Li, Rui Chen

Faculty, Staff and Students Publications

In the studies of Inherited Retinal Diseases (IRDs), the knockout of traditional animal models like mice often fails to accurately replicate human phenotypes due to genetic and anatomical differences. Human retinal organoids (ROs) derived from stem cells have emerged as promising developmental models in retinal studies to delineate cell growth, but their ability to represent the characteristics of late-onset IRDs remains unclear. This study aims to validate ROs as a disease model for Stargardt's Disease (STGD) caused by ABCA4 mutations. Using single-cell RNA sequencing, ROs from 2 STGD patients were compared with healthy control-derived ROs at two developmental stages on …

Fast And Accurate Measurement Of Small Field Dosimetry Using A Novel Scintillation Detector, Yiding Han, Jingzhu Xu, Yao Hao, Baozhou Sun

Faculty, Staff and Students Publications

Background: The most used instruments for small-field dosimetry have notable limitations, including the need for correction of output factors, limited scanning speeds, and challenges in alignment for percentage depth dose (PDD) measurements, particularly for extremely small fields. However, plastic scintillation detectors (PSDs) are an attractive alternative for small-field dosimetry due to their correction-free nature, linear dose response, and fast response time.

Purpose: This study evaluates the robustness and accuracy of the dosimetric measurements using a new water-equivalent PSD in small-field dosimetry. The study also aims to report accurate measurements of output factors, profiles, and an indirect method for measuring PDD …

Meniscal Repair In The Setting Of Revision Anterior Cruciate Ligament Reconstruction: 6-Year Follow-Up Results From The Mars Cohort, Mars Group, Amanda K Haas, Robert H Brophy, Matthew J Matava, Matthew V Smith, Et Al.

2020-Current year OA Pubs

BACKGROUND: Meniscal preservation has been demonstrated to contribute to long-term knee health and has been a successful intervention in isolation and in patients with anterior cruciate ligament reconstruction (ACLR). The long-term results of meniscal repair in the setting of revision ACLR have yet to be documented.

PURPOSE: To report the incidence of meniscal repair failures at the 6-year follow-up in a cohort of patients who underwent concurrent revision ACLR and primary meniscal repair.

STUDY DESIGN: Prospective cohort study; Level of evidence, 2.

METHODS: All revision ACLRs with concomitant primary meniscal repair cases from a multicenter group between 2006 and 2011 …

Re: Approval Letter For The Final Butte Priority Soils Operable Unit (Bpsou) Butte Treatment Lagoons (Btl) Groundwater Treatment System Quarterly Operation And Maintenance Report – Quarter 2 2024 (Dated August 19, 2025), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Re: Comment Letter For The Butte Priority Soils Operable Unit (Bpsou) Butte Treatment Lagoons (Btl) Groundwater Treatment System Quarterly Operation And Maintenance Report – Quarter 2 2025 (Dated September 30, 2025), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Re: Approval Letter For The Final Butte Priority Soils Operable Unit (Bpsou) Butte Treatment Lagoons (Btl) Groundwater Treatment System Quarterly Operation And Maintenance Report – Quarter 1 2024 (Dated August 14, 2025), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Draft Final 2022 Insufficiently Reclaimed Sites Sampling: Bres No. 96 – Washoe Dump Site Evaluation Summary Report, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Revised Draft Final 2022 Unreclaimed Sites Sampling: Ur-22 Site Evaluation Summary Report, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Reconstruction Of Traumatic Carotidcavernous Fistula Using A Covered Stent, Julio Calderon, Ravi Shastri, Guhanand Venkataraman, Mohadese Ahmadzade, Mohammad Ghasemi-Rad

Faculty, Staff and Students Publications

A traumatic carotid-cavernous fistula (CCF) is a significant neurovascular condition characterized by an abnormal connection between the carotid artery and the cavernous sinus, often resulting from head trauma. This condition can lead to serious complications, necessitating effective management strategies. Endovascular treatment is the preferred approach for managing this condition. We present a case of a 23-year-old male with persistent left eye pain and redness seven months post-motor vehicle collision. Cerebral angiography confirmed a high-flow CCF with compromised intracranial flow, successfully treated with a 5 mm PK Papyrus covered stent using a novel tri-axial delivery system. This case highlights the efficacy …

Evaluating Covid-19 Severity Prediction And Immune Dynamics With Nulisaseq: Insights From The Impacc Study, Koji Abe, Tyson H Holmes, Tran T Nguyen, Seunghee Kim-Schulze, Ofer Levy, Lindsey R Baden, Esther Melamed, Lauren I R Ehrlich, Grace A Mccomsey, Rafick P Sekaly, Charles B Cairns, Elias K Haddad, Albert C Shaw, David A Hafler, Ruth R Montgomery, David B Corry, Farrah Kheradmand, Mark A Atkinson, Scott C Brakenridge, Nelson I Agudelo Higuita, Jordan P Metcalf, Catherine L Hough, William B Messer, Bali Pulendran, Kari C Nadeau, Mark M Davis, Ana Fernandez-Sesma, Viviana Simon, Monica Kraft, Chris Bime, Carolyn S Calfee, David J Erle, Joanna Schaenman, Elaine F Reed, Al Ozonoff, Bjoern Peters, Steven H Kleinstein, Alison D Augustine, Joann Diray-Arce, Patrice M Becker, Nadine Rouphael, Holden T Maecker

Faculty, Staff and Students Publications

The National Institutes of Health-funded IMPACC (IMmunoPhenotyping Assessment in a COVID-19 Cohort) evaluated longitudinal clinical and immunological features of human patients hospitalized for COVID-19. This study focuses on comparing the novel NULISAseq assay with the Olink platform using a subset of participants to assess their efficacy in predicting COVID-19 severity and understanding immune response dynamics. Our findings reveal that NULISAseq could provide superior detectability and dynamic range across various targets. Elastic net analysis demonstrated that specific proteins, including amphiregulin, effectively predict COVID-19 severity from sera at admission (samples drawn within 96 h of admission), with a test area under the …

Administration Of A Novel Reprogramming Formula Improves Cardiac Function And Decreases Cardiac Fibrosis In A Myocardial Infarction Model, Megumi Mathison, Saliha S Pathan, Aliya Lackan, Jianchang Yang, Tamer M A Mohamed, Todd K Rosengart

Faculty, Staff and Students Publications

Background: The reprogramming of fibroblasts into (induced) cardiomyocytes offers a direct myocardial regeneration strategy for improving postinfarction myocardial function. Compared to lower-order species, human cells are relatively resistant to such reprogramming. We previously found that p63-transactivation inhibitory domain (TID; the portion of p63 that physical interacts and interferes with its activation of the epigenetic repressor HDAC1) combined with the cardio-differentiation factors Hand2 and Myocardin (HM) enhanced rat and human cell transdifferentiation. The present study sought to determine the in vivo effects of this reprogramming strategy in a rat myocardial infarction model.

Methods: Adult male and female rats underwent left anterior …

Summarizing Attributable Factors And Evaluating Risk Of Bias Of Mendelian Randomization Studies For Alzheimer’S Dementia And Cognitive Status: A Systematic Review And Meta-Analysis, Xiaoni Meng, Xiaochun Li, Meiling Cao, Jing Dong, Haotian Wang, Weijie Cao, Di Liu, Youxin Wang

Research outputs 2022 to 2026

Background: No effective treatment is available to delay or reverse the onset and progression of Alzheimer’s dementia (AD). Mild cognitive impairment, a clinical state between normal aging and AD, may offer the proper window for AD intervention and treatment. This systematic review aimed to summarize evidence from Mendelian randomization (MR) studies exploring factors attributable to AD and related cognitive status and to assess its credibility. Methods: We searched PubMed, Embase, MEDLINE, and the Cochrane Library to identify MR studies investigating the associations between any factor and AD and related cognitive status. The risk of bias in MR studies was evaluated …

Performance Study Of A Woody Downdraft Gasifier: Numerical Investigation And Experimental Validation, Md Sanowar Hossain, Showmitro Bhowmik, Mujahidul Islam Riad, Md Golam Kibria, Barun K. Das, Sanjay Paul

Research outputs 2022 to 2026

Biomass gasification is an established and widely utilized renewable energy system. The research work aims to develop and construct a downdraft gasifier to investigate gasifier performance. The gasifier’s performance and cold gas efficiency were calculated for three volumetric airflow rates: 7.16 m3/h, 5.97 m3/h, and 4.78 m3/h. The efficiency was found maximum of 69.6% for an airflow rate of 7.16 m3/h. The oxidation zone and neck region of the gasifier reactor had the maximum recorded temperatures of 845 °C and 823 °C for Swietenia macrophylla (SM) and Mangifera indica (MI), respectively. A two-dimensional computational fluid dynamics (CFD) model for a …

Culturally Responsive Recommendations For Eating Disorder Prevention And Management For First Nations Peoples In Australia: A Policy Scoping Review, Zyana Gall, Hilary Smith, Gabrielle Grant, Kanita Kunaratnam, Carissa Lee, Felicity Kerslake, Alana Gall

Research outputs 2022 to 2026

Background: Evidence suggests First Nations people in Australia may experience a higher burden of eating disorders (EDs) than the broader Australian population. EDs are among the most debilitating and lethal mental health conditions; however, little is known about the unique considerations for First Nations people experiencing EDs, especially around best practices. This policy scoping review aims to map the current recommendations for managing EDs specific to First Nations peoples and to identify further research opportunities. Methods: We conducted targeted searches of electronic databases and health websites (n = 53) for policies, reports, toolkits/guidelines, and fact sheets that contained any information …

The Influence Of The Marker Set On Inverse Kinematics Results To Inform Markerless Motion Capture Annotations, Marion Mundt, David Pagnon, Steffi Colyer

Research outputs 2022 to 2026

Markerless motion capture has the potential to enable biomechanical analyses without specialised, high-cost equipment. However, the comparability of many markerless motion capture frameworks with the most used marker-based method is limited. One reason for this is the lack of high-quality, biomechanically-informed datasets that are needed to train markerless models. This study aimed to inform the development of such a dataset by systematically analysing the agreement between a gold-standard marker set and a reduced number of markers to solve inverse kinematics (IK). We analysed the impact of different marker positions on the IK solution using an OpenSim lower body model with …

Cnn Based Deep Learning Modeling With Explainability Analysis For Detecting Fraudulent Blockchain Transactions, Mohammad Hasan, Mohammad Shahriar Rahman, Mohammad Jabed Morshed Chowdhury, Iqbal H. Sarker

Research outputs 2022 to 2026

In the era of growing cryptocurrency adoption, Blockchain has emerged as a leading player in the digital payment landscape. However, this widespread popularity also brings forth various security challenges, including the need to safeguard against fraudulent activities. One of the paramount challenges in this regard is the detection of fraudulent transactions within the realm of Bitcoin data. This task significantly influences the trust and security of digital payments. Yet, it's a formidable challenge given the relatively low occurrence of fraudulent Bitcoin transactions. While deep learning techniques have demonstrated their prowess in fraud detection, there remains a scarcity of studies exploring …